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Tytuł :
Cell Type-Dependent Escape of Capsid Inhibitors by Simian Immunodeficiency Virus SIVcpz.
Autorzy :
Twizerimana AP; Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Scheck R; Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Becker D; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Zhang Z; Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Wammers M; Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Avelar L; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Pflieger M; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Häussinger D; Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Kurz T; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Gohlke H; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; John von Neumann Institute for Computing, Forschungszentrum Jülich GmbH, Jülich, Germany.; Jülich Supercomputing Centre, Forschungszentrum Jülich GmbH, Jülich, Germany.; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Jülich, Germany.
Münk C; Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany .
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Źródło :
Journal of virology [J Virol] 2020 Nov 09; Vol. 94 (23). Date of Electronic Publication: 2020 Nov 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*pharmacology
Capsid/*drug effects
Capsid Proteins/*chemistry
Capsid Proteins/*drug effects
Capsid Proteins/*metabolism
Simian Immunodeficiency Virus/*drug effects
mRNA Cleavage and Polyadenylation Factors/*chemistry
mRNA Cleavage and Polyadenylation Factors/*metabolism
Animals ; Binding Sites ; Capsid Proteins/genetics ; Cell Line ; Cyclophilin A/genetics ; Cyclophilin A/metabolism ; Gene Knockout Techniques ; HEK293 Cells ; HIV-1 ; HeLa Cells ; Humans ; Indazoles/pharmacology ; Indoles/pharmacology ; Leukocytes, Mononuclear/virology ; Macrophages/virology ; Models, Molecular ; Pan troglodytes/virology ; Phenylalanine/analogs & derivatives ; Phenylalanine/pharmacology ; Protein Conformation ; Protein Interaction Domains and Motifs ; Pyridines/pharmacology ; Sequence Alignment ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/chemistry ; Simian Immunodeficiency Virus/genetics ; Zoonoses ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
Epidemiology, clinical picture and long-term outcomes of FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia: Data from 151 patients.
Autorzy :
Rohmer J; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Department of Internal Medicine, Hôpital Foch, Suresnes, France.
Couteau-Chardon A; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Department of Intensive Care medicine, Centre Hospitalier Annecy Genevois, Saint-Julien-en-Genevois, France.
Trichereau J; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Clinical Research Department, Hôpital Foch, Suresnes, France.
Panel K; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Clinical Research Department, Hôpital Foch, Suresnes, France.
Gesquiere C; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.
Ben Abdelali R; Pole Hématologie et Oncologie, Laboratoire CERBA, Saint-Ouen-l'Aumône, France.
Bidet A; Laboratory of Hematology, CHU de Bordeaux, Pessac, France.
Bladé JS; Department of Oncology, Sainte-Anne Military Teaching Hospital, Toulon, France.
Cayuela JM; Laboratory of Hematology, Saint-Louis Hospital, University of Paris, Paris, France.
Cony-Makhoul P; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Hematology Department, CH Annecy Genevois, Annecy, France.
Cottin V; National Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Lyon, France.; Hospices Civils de Lyon, UMR754, University Claude Bernard Lyon 1, Lyon, France.
Delabesse E; Laboratory of Hematology, Institut Universitaire du Cancer de Toulouse Oncopole, CHU de Toulouse, Toulouse, France.
Ebbo M; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Aix Marseille University, Department of Internal Medicine, Hôpital de la Timone, AP-HM, CNRS, INSERM, CIML, Marseille, France.
Fain O; Department of Internal Medicine, CHU Saint Antoine, Paris, France.
Flandrin P; Laboratory of Hematology, Hôpital Nord, CHU de Saint-Étienne, Saint-Étienne, France.
Galicier L; Department of Clinical Immunology, Saint Louis hospital, Paris, France.
Godon C; Laboratoire de cytogénétique hématologique, CHU de Nantes, Nantes, France.
Grardel N; Laboratory of Hematology, CHU de Lille, Lille, France.
Guffroy A; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Department of Clinical Immunology and Internal Medicine, National Reference Center for Systemic Autoimmune Diseases (RESO), Tertiary Center for Primary Immunodeficiency, Strasbourg University Hospital, Strasbourg, France.
Hamidou M; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Department of Internal Medicine, CHU de Nantes, Nantes, France.
Hunault M; CRCINA CHU d'Angers, Angers, France.
Lengline E; Department of Hematology, Saint Louis hospital, Paris, France.
Lhomme F; Department of Hematology, CHU Pontchaillou, Rennes, France.
Lhermitte L; University of Paris, Institut National de Recherche Médicale U1151, Laboratory of Onco-Hematology, Hôpital Necker Enfants-Malades, Paris, France.
Machelart I; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Department of Internal Medicine, CHU de Bordeaux, Bordeaux, France.
Mauvieux L; Université de Strasbourg, INSERM U1113 Interface de Recherche Fondamentale et Appliquée en Cancérologie, Laboratoire d'hématologie du CHRU Strasbourg, Faculté de Médecine de Strasbourg, Strasbourg, France.
Mohr C; Service d'Hématologie Oncologie, CHU, Groupe Hospitalier Sud Réunion, Saint Pierre, Reunion, France.
Mozicconacci MJ; Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, Biopathologie, Marseille, France.
Naguib D; Laboratory of Hematology, CHU Caen, Caen, France.
Nicolini FE; Department of Hematology, INSERM U 1052, CRCL, Centre Léon Bérard, Lyon, France.
Rey J; Department of Hematology, Institut Paoli-Calmettes, Marseille, France.
Rousselot P; Hematology Department, Versailles André Mignot Hospital, University Paris-Saclay, Le Chesnay, France.
Tavitian S; Service d'Hématologie, Institut Universitaire du Cancer de Toulouse-Oncopole, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Terriou L; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Université de Lille, CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France.
Lefèvre G; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Université de Lille, CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France.
Preudhomme C; Laboratory of Hematology, CHU de Lille, Lille, France.
Kahn JE; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Université Paris-Saclay, Department of Internal Medicine, Ambroise Paré hospital, Boulogne Billancourt Cedex, France.
Groh M; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Department of Internal Medicine, Hôpital Foch, Suresnes, France.
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Corporate Authors :
CEREO and GBMHM collaborators
Źródło :
American journal of hematology [Am J Hematol] 2020 Nov; Vol. 95 (11), pp. 1314-1323. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study
MeSH Terms :
Eosinophilia*/blood
Eosinophilia*/drug therapy
Eosinophilia*/genetics
Eosinophilia*/mortality
Hematologic Neoplasms*/blood
Hematologic Neoplasms*/drug therapy
Hematologic Neoplasms*/genetics
Hematologic Neoplasms*/mortality
Myeloproliferative Disorders*/blood
Myeloproliferative Disorders*/drug therapy
Myeloproliferative Disorders*/genetics
Myeloproliferative Disorders*/mortality
Oncogene Proteins, Fusion*/blood
Oncogene Proteins, Fusion*/genetics
Receptor, Platelet-Derived Growth Factor alpha*/blood
Receptor, Platelet-Derived Growth Factor alpha*/genetics
mRNA Cleavage and Polyadenylation Factors*/blood
mRNA Cleavage and Polyadenylation Factors*/genetics
Adrenal Cortex Hormones/*administration & dosage
Adult ; Disease-Free Survival ; Female ; France/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Retrospective Studies ; Survival Rate ; Tryptases/blood ; Vitamin B 12/blood
Czasopismo naukowe
Tytuł :
The HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b.
Autorzy :
Chaudhuri E; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.
Dash S; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.; School of Biotechnology, KIIT University, Bhubaneswar, Odisha 751024, India.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York 10065.
Balasubramaniam M; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.
Padron A; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee 37208.; School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee 37208.
Holland J; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.
Sowd GA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.
Villalta F; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee 37208.
Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.
Pandhare J; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee 37208.; School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee 37208.
Dash C; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208 .; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.; School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee 37208.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Apr 10; Vol. 295 (15), pp. 5081-5094. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
3' Untranslated Regions/*genetics
Capsid/*metabolism
HIV Infections/*virology
HIV-1/*physiology
MicroRNAs/*genetics
mRNA Cleavage and Polyadenylation Factors/*metabolism
Binding Sites ; HIV Infections/genetics ; HIV Infections/metabolism ; Humans ; MicroRNAs/metabolism ; Mutation ; Virus Integration ; mRNA Cleavage and Polyadenylation Factors/chemistry ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
A scaffold lncRNA shapes the mitosis to meiosis switch.
Autorzy :
Andric V; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France.
Nevers A; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France.; University Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350, Jouy-en-Josas, France.
Hazra D; Laboratoire de Biologie Structurale de la Cellule (BIOC), CNRS, Ecole polytechnique, Institut Polytechnique de Paris, 91128, Palaiseau, France.; Department of Biochemistry, Oxford University, Oxford, OX1 3QU, UK.
Auxilien S; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France.
Menant A; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France.
Graille M; Laboratoire de Biologie Structurale de la Cellule (BIOC), CNRS, Ecole polytechnique, Institut Polytechnique de Paris, 91128, Palaiseau, France.
Palancade B; Université de Paris, CNRS, Institut Jacques Monod, F-75006, Paris, France.
Rougemaille M; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 03; Vol. 12 (1), pp. 770. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Fungal*
Meiosis/*genetics
Mitosis/*genetics
RNA, Fungal/*genetics
RNA, Long Noncoding/*genetics
Schizosaccharomyces/*genetics
Protein Binding ; RNA Stability/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism ; mRNA Cleavage and Polyadenylation Factors/genetics ; mRNA Cleavage and Polyadenylation Factors/metabolism
Czasopismo naukowe
Tytuł :
Factors that mold the nuclear landscape of HIV-1 integration.
Autorzy :
Bedwell GJ; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 25; Vol. 49 (2), pp. 621-635.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Host-Pathogen Interactions*
Virus Integration*/genetics
Virus Integration*/physiology
HIV-1/*physiology
Human Immunodeficiency Virus Proteins/*metabolism
Active Transport, Cell Nucleus ; Adaptor Proteins, Signal Transducing/deficiency ; Adaptor Proteins, Signal Transducing/physiology ; Capsid Proteins/metabolism ; Cell Nucleus/metabolism ; Cell Nucleus/virology ; Chromatin/genetics ; Chromatin/metabolism ; Cytoplasm/metabolism ; Cytoplasm/virology ; Cytoskeletal Proteins/metabolism ; HIV Reverse Transcriptase/physiology ; HIV-1/enzymology ; HIV-1/genetics ; Human Immunodeficiency Virus Proteins/genetics ; Humans ; Interphase ; Models, Molecular ; Multiprotein Complexes/metabolism ; Nuclear Pore/metabolism ; Nuclear Proteins/metabolism ; Protein Conformation ; Protein Domains ; Transcription Factors/deficiency ; Transcription Factors/physiology ; Virus Latency ; Virus Replication ; mRNA Cleavage and Polyadenylation Factors/deficiency ; mRNA Cleavage and Polyadenylation Factors/physiology
Czasopismo naukowe
Tytuł :
CPSF7 regulates liver cancer growth and metastasis by facilitating WWP2-FL and targeting the WWP2/PTEN/AKT signaling pathway.
Autorzy :
Fang S; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Zhang D; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Weng W; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Lv X; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Zheng L; Lishui Hospital of Zhejiang University, China.
Chen M; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Fan X; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Mao J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Mao C; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Ye Y; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Xu M; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China. Electronic address: .
Ji J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2020 Feb; Vol. 1867 (2), pp. 118624. Date of Electronic Publication: 2019 Dec 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver Neoplasms/*pathology
PTEN Phosphohydrolase/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
RNA Recognition Motif Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
mRNA Cleavage and Polyadenylation Factors/*metabolism
Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Female ; Humans ; Liver Neoplasms/metabolism ; Male ; Mice ; Mice, Nude ; Middle Aged ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA Interference ; RNA Recognition Motif Proteins/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Transplantation, Heterologous ; Ubiquitin-Protein Ligases/genetics ; mRNA Cleavage and Polyadenylation Factors/antagonists & inhibitors ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
Acute myeloid leukemia with a novel CPSF6-RARG variant is sensitive to homoharringtonine and cytarabine chemotherapy.
Autorzy :
Zhang Z; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China.; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jiang M; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Borthakur G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Luan S; Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Huang X; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Tang G; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Xu Q; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Ji D; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Boyer AD; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Li F; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Huang R; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
You MJ; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Źródło :
American journal of hematology [Am J Hematol] 2020 Feb; Vol. 95 (2), pp. E48-E51. Date of Electronic Publication: 2019 Dec 31.
Typ publikacji :
Case Reports; Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/metabolism
Leukemia, Myeloid, Acute*/pathology
Oncogene Proteins, Fusion*/genetics
Oncogene Proteins, Fusion*/metabolism
Receptors, Retinoic Acid*/genetics
Receptors, Retinoic Acid*/metabolism
mRNA Cleavage and Polyadenylation Factors*/genetics
mRNA Cleavage and Polyadenylation Factors*/metabolism
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Cytarabine/administration & dosage ; Homoharringtonine/administration & dosage ; Humans ; Male ; Middle Aged
Raport
Tytuł :
Exquisite response to imatinib mesylate in FIP1L1-PDGFRA-mutated hypereosinophilic syndrome: a 12-year experience of the Polish Hypereosinophilic Syndrome Study Group.
Autorzy :
Helbig G; Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland. />Lewandowski K; Department of Hematology and Stem Cell Transplantation, Poznan University of Medical Sciences, Poznań, Poland
Świderska A; Department of Hematology, Regional Hospital, Zielona Góra, Poland
Rodzaj M; Department of Hematology, Rydygier Hospital, Kraków, Poland
Seferyńska I; Institute of Hematology and Transfusion Medicine, Warsaw, Poland
Gajkowska-Kulik J; Department of Hematology, Regional Hospital, Toruń, Poland
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Źródło :
Polish archives of internal medicine [Pol Arch Intern Med] 2020 Mar 27; Vol. 130 (3), pp. 255-257. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Mutation*
Oncogene Proteins, Fusion*
Receptor, Platelet-Derived Growth Factor alpha*
mRNA Cleavage and Polyadenylation Factors*
Hypereosinophilic Syndrome/*drug therapy
Imatinib Mesylate/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Hypereosinophilic Syndrome/genetics ; Male ; Middle Aged ; Poland ; Protein Kinase Inhibitors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.
Autorzy :
Yang SW; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Li L; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Connelly JP; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Porter SN; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kodali K; Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Gan H; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Park JM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tacer KF; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tillman H; Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Peng J; Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Li W; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Potts PR; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Mar 19; Vol. 77 (6), pp. 1206-1221.e7. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
3' Untranslated Regions/*genetics
Antigens, Neoplasm/*metabolism
Lung Neoplasms/*pathology
Neoplasm Proteins/*metabolism
Ovarian Neoplasms/*pathology
RNA, Messenger/*metabolism
Ubiquitin/*metabolism
mRNA Cleavage and Polyadenylation Factors/*metabolism
Animals ; Antigens, Neoplasm/genetics ; Apoptosis ; Biomarkers, Tumor ; Carcinogenesis ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Proliferation ; Cleavage And Polyadenylation Specificity Factor/genetics ; Cleavage And Polyadenylation Specificity Factor/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Proteins/genetics ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Polyadenylation ; RNA Splicing ; RNA, Messenger/genetics ; Tumor Cells, Cultured ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; Xenograft Model Antitumor Assays ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
Meiotic gene silencing complex MTREC/NURS recruits the nuclear exosome to YTH-RNA-binding protein Mmi1.
Autorzy :
Shichino Y; Laboratory of Cell Responses, National Institute for Basic Biology, Myodaiji, Okazaki, Aichi, Japan.
Otsubo Y; Laboratory of Cell Responses, National Institute for Basic Biology, Myodaiji, Okazaki, Aichi, Japan.; National Institute for Fusion Science, Toki, Gifu, Japan.; Center for Novel Science Initiatives, National Institutes of Natural Sciences, Myodaiji, Okazaki, Aichi, Japan.
Yamamoto M; Laboratory of Cell Responses, National Institute for Basic Biology, Myodaiji, Okazaki, Aichi, Japan.; Department of Basic Biology, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Myodaiji, Okazaki, Aichi, Japan.
Yamashita A; Laboratory of Cell Responses, National Institute for Basic Biology, Myodaiji, Okazaki, Aichi, Japan.; Center for Novel Science Initiatives, National Institutes of Natural Sciences, Myodaiji, Okazaki, Aichi, Japan.; Department of Basic Biology, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Myodaiji, Okazaki, Aichi, Japan.
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Źródło :
PLoS genetics [PLoS Genet] 2020 Feb 03; Vol. 16 (2), pp. e1008598. Date of Electronic Publication: 2020 Feb 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Fungal*
RNA Interference*
Carrier Proteins/*metabolism
Exosomes/*metabolism
Meiosis/*genetics
Schizosaccharomyces pombe Proteins/*metabolism
mRNA Cleavage and Polyadenylation Factors/*metabolism
DEAD-box RNA Helicases/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Ribonucleases/genetics ; Ribonucleases/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
Cellular Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Mediates Nuclear Import of Human Bocavirus 1 NP1 Protein and Modulates Viral Capsid Protein Expression.
Autorzy :
Wang X; School of Life Sciences and Technology, Wuhan University of Bioengineering, Wuhan, Hubei, China.; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Xu P; School of Life Sciences and Technology, Wuhan University of Bioengineering, Wuhan, Hubei, China.; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Cheng F; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Li Y; School of Life Sciences and Technology, Wuhan University of Bioengineering, Wuhan, Hubei, China.
Wang Z; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Hao S; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Wang J; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Ning K; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Ganaie SS; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Engelhardt JF; Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, USA.
Yan Z; Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, USA.
Qiu J; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA .
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Źródło :
Journal of virology [J Virol] 2020 Jan 06; Vol. 94 (2). Date of Electronic Publication: 2020 Jan 06 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Nucleus*/genetics
Cell Nucleus*/metabolism
Cell Nucleus*/virology
Gene Expression Regulation, Viral*
RNA, Messenger*/genetics
RNA, Messenger*/metabolism
RNA, Viral*/genetics
RNA, Viral*/metabolism
Capsid Proteins/*biosynthesis
Human bocavirus/*metabolism
Nuclear Proteins/*metabolism
mRNA Cleavage and Polyadenylation Factors/*metabolism
Active Transport, Cell Nucleus ; Capsid Proteins/genetics ; HEK293 Cells ; Human bocavirus/genetics ; Humans ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Nuclear Proteins/genetics ; RNA Helicases/genetics ; RNA Helicases/metabolism ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
Depletion of CPEB1 protects against oxidized LDL-induced endothelial apoptosis and inflammation though SIRT1/LOX-1 signalling pathway.
Autorzy :
Xu K; Department of Anesthesiology, China-Japan Union Hospital JiLin University, Chang Chun, JiLin, 130033, China.
Xiwen Liu; Department of Vascular Surgery, China-Japan Union Hospital JiLin University, Chang Chun, JiLin, 130033, China.
Ren G; Department of Vascular Surgery, China-Japan Union Hospital JiLin University, Chang Chun, JiLin, 130033, China.
Yin D; Department of Vascular Surgery, China-Japan Union Hospital JiLin University, Chang Chun, JiLin, 130033, China.
Guo S; Department of Vascular Surgery, China-Japan Union Hospital JiLin University, Chang Chun, JiLin, 130033, China.
Zhao Y; Department of Vascular Surgery, China-Japan Union Hospital JiLin University, Chang Chun, JiLin, 130033, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2019 Dec 15; Vol. 239, pp. 116874. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji :
Journal Article
MeSH Terms :
Scavenger Receptors, Class E/*metabolism
Sirtuin 1/*metabolism
Transcription Factors/*deficiency
mRNA Cleavage and Polyadenylation Factors/*deficiency
Apoptosis/physiology ; Atherosclerosis/metabolism ; Atherosclerosis/physiopathology ; Endothelium/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Inflammation/metabolism ; Lipoproteins, LDL/metabolism ; Oxidative Stress/drug effects ; Signal Transduction ; Transcription Factors/metabolism ; mRNA Cleavage and Polyadenylation Factors/metabolism
Czasopismo naukowe
Tytuł :
Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
Autorzy :
Yang Q; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.
Fan W; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China. Electronic address: .
Zheng Z; Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-sen University Cancer Center, Guangzhou, China.
Lin S; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China. Electronic address: .
Liu C; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Wang R; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Li W; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Zuo Y; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Sun Y; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Hu S; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Chen M; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Guo P; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Pan J; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Tian C; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Zhu T; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Diao C; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Hao J; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China.
Yu W; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China. Electronic address: .
Li L; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China. Electronic address: .
Li Y; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China. Electronic address: .
Guo W; Institute of Cancer Stem Cells, Dalian Medical University, Dalian, China. Electronic address: .
Deng W; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China. Electronic address: .
Wu X; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2019 Oct; Vol. 1866 (10), pp. 1533-1543. Date of Electronic Publication: 2019 Jul 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Cleavage And Polyadenylation Specificity Factor/*metabolism
Colonic Neoplasms/*metabolism
Genetic Predisposition to Disease/*genetics
mRNA Cleavage and Polyadenylation Factors/*metabolism
Animals ; Cell Cycle ; Cell Cycle Checkpoints ; Cell Line, Tumor ; Cell Survival ; Cleavage And Polyadenylation Specificity Factor/genetics ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Peptide Fragments/metabolism ; Promoter Regions, Genetic ; Telomerase/metabolism ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.
Autorzy :
Bester SM; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Wei G; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Zhao H; Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Adu-Ampratwum D; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Iqbal N; Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Courouble VV; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA.
Francis AC; Department of Pediatrics, Infectious Diseases, Emory University, Atlanta, GA 30322, USA.
Annamalai AS; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Singh PK; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Shkriabai N; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Van Blerkom P; Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Morrison J; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Poeschla EM; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Melikyan GB; Department of Pediatrics, Infectious Diseases, Emory University, Atlanta, GA 30322, USA.
Griffin PR; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA.
Fuchs JR; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Asturias FJ; Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA. .
Kvaratskhelia M; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Oct 16; Vol. 370 (6514), pp. 360-364.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Anti-HIV Agents/*chemistry
Anti-HIV Agents/*pharmacology
Capsid/*chemistry
HIV-1/*chemistry
Capsid/drug effects ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Deuterium Exchange Measurement ; HEK293 Cells ; HIV-1/drug effects ; HeLa Cells ; Humans ; Nuclear Pore Complex Proteins/chemistry ; Protein Domains ; mRNA Cleavage and Polyadenylation Factors/chemistry
Czasopismo naukowe
Tytuł :
Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription.
Autorzy :
Declercq M; Unité Génétique Moléculaire des Virus à ARN, UMR3569 CNRS, Université de Paris, Département de Virologie, Institut Pasteur, Paris, France.
Biquand E; Unité Génétique Moléculaire des Virus à ARN, UMR3569 CNRS, Université de Paris, Département de Virologie, Institut Pasteur, Paris, France.
Karim M; Unité Génétique Moléculaire des Virus à ARN, UMR3569 CNRS, Université de Paris, Département de Virologie, Institut Pasteur, Paris, France.
Pietrosemoli N; Bioinformatics and Biostatistics Hub, Department of Computational Biology, Institut Pasteur, USR 3756 CNRS, Paris, France.
Jacob Y; Unité Génétique Moléculaire des Virus à ARN, UMR3569 CNRS, Université de Paris, Département de Virologie, Institut Pasteur, Paris, France.
Demeret C; Unité Génétique Moléculaire des Virus à ARN, UMR3569 CNRS, Université de Paris, Département de Virologie, Institut Pasteur, Paris, France.
Barbezange C; Unité Génétique Moléculaire des Virus à ARN, UMR3569 CNRS, Université de Paris, Département de Virologie, Institut Pasteur, Paris, France.
van der Werf S; Unité Génétique Moléculaire des Virus à ARN, UMR3569 CNRS, Université de Paris, Département de Virologie, Institut Pasteur, Paris, France.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10428-10440.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Exoribonucleases/*genetics
Influenza A virus/*genetics
Influenza, Human/*genetics
Nuclear Proteins/*genetics
mRNA Cleavage and Polyadenylation Factors/*genetics
Cell Line ; Histones/genetics ; Host-Pathogen Interactions ; Humans ; Influenza A virus/pathogenicity ; Influenza, Human/virology ; RNA Stability/genetics ; RNA, Messenger/genetics ; RNA, Small Interfering ; RNA, Viral/genetics ; Ribonucleoproteins/genetics ; Transcription, Genetic/genetics ; Viral Proteins/genetics ; Virus Replication/genetics
Czasopismo naukowe
Tytuł :
Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.
Autorzy :
Yang SW; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Huang X; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Lin W; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Min J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Miller DJ; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Mayasundari A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Rodrigues P; Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Griffith EC; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Gee CT; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Li L; Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California Irvine, 5270 California Ave, Irvine, CA, 92617, USA.
Li W; Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California Irvine, 5270 California Ave, Irvine, CA, 92617, USA.
Lee RE; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Rankovic Z; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Potts PR; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 01; Vol. 11 (1), pp. 4931. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antigens, Neoplasm/*ultrastructure
Neoplasm Proteins/*ultrastructure
Neoplasms/*drug therapy
Ubiquitin-Protein Ligases/*metabolism
mRNA Cleavage and Polyadenylation Factors/*metabolism
Amino Acid Motifs ; Aminoquinolines/pharmacology ; Aminoquinolines/therapeutic use ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Carcinogenesis/drug effects ; Drug Screening Assays, Antitumor ; HEK293 Cells ; HeLa Cells ; High-Throughput Screening Assays ; Humans ; Mutagenesis ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Neoplasms/genetics ; Neoplasms/pathology ; Proof of Concept Study ; Protein Binding/drug effects ; Protein Binding/genetics ; Protein Domains/genetics ; Protein Interaction Mapping ; Structure-Activity Relationship ; Substrate Specificity/drug effects ; Substrate Specificity/genetics ; Ubiquitination/drug effects ; Ubiquitination/genetics
Czasopismo naukowe
Tytuł :
The polyadenylation factor FIP1 is important for plant development and root responses to abiotic stresses.
Autorzy :
Téllez-Robledo B; Centro de Biotecnología y Genómica de Plantas (CBGP), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Campus de Montegancedo, Pozuelo de Alarcón, 28223, Madrid, Spain.
Manzano C; Centro de Biotecnología y Genómica de Plantas (CBGP), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Campus de Montegancedo, Pozuelo de Alarcón, 28223, Madrid, Spain.; Department of Plant Biology and Genome Center, University of California Davis, 1 Shields Avenue, Davis, CA, 95616, USA.
Saez A; Centro de Biotecnología y Genómica de Plantas (CBGP), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Campus de Montegancedo, Pozuelo de Alarcón, 28223, Madrid, Spain.; DTD, Timac Agro Spain, Lodosa, 31580, Navarra, Spain.
Navarro-Neila S; Centro de Biotecnología y Genómica de Plantas (CBGP), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Campus de Montegancedo, Pozuelo de Alarcón, 28223, Madrid, Spain.
Silva-Navas J; Centro de Biotecnología y Genómica de Plantas (CBGP), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Campus de Montegancedo, Pozuelo de Alarcón, 28223, Madrid, Spain.
de Lorenzo L; Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY, 40546-0312, USA.
González-García MP; Centro de Biotecnología y Genómica de Plantas (CBGP), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Campus de Montegancedo, Pozuelo de Alarcón, 28223, Madrid, Spain.
Toribio R; Centro de Biotecnología y Genómica de Plantas (CBGP), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Campus de Montegancedo, Pozuelo de Alarcón, 28223, Madrid, Spain.
Hunt AG; Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY, 40546-0312, USA.
Baigorri R; DTD, Timac Agro Spain, Lodosa, 31580, Navarra, Spain.
Casimiro I; Facultad de Ciencias, Department de Anatomía, Biología Celular y Zoología, Universidad de Extremadura, 06006, Badajoz, Spain.
Brady SM; Department of Plant Biology and Genome Center, University of California Davis, 1 Shields Avenue, Davis, CA, 95616, USA.
Castellano MM; Centro de Biotecnología y Genómica de Plantas (CBGP), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Campus de Montegancedo, Pozuelo de Alarcón, 28223, Madrid, Spain.
Del Pozo JC; Centro de Biotecnología y Genómica de Plantas (CBGP), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Campus de Montegancedo, Pozuelo de Alarcón, 28223, Madrid, Spain.
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Źródło :
The Plant journal : for cell and molecular biology [Plant J] 2019 Sep; Vol. 99 (6), pp. 1203-1219. Date of Electronic Publication: 2019 Jun 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arabidopsis/*metabolism
Arabidopsis Proteins/*metabolism
Plant Roots/*metabolism
Polyadenylation/*genetics
Salt Stress/*genetics
mRNA Cleavage and Polyadenylation Factors/*metabolism
5' Untranslated Regions ; Abscisic Acid/metabolism ; Alleles ; Arabidopsis/drug effects ; Arabidopsis/growth & development ; Arabidopsis Proteins/genetics ; Cadmium/toxicity ; Cell Division/genetics ; Gene Expression Regulation, Plant/genetics ; Mutation ; Phenotype ; Plant Roots/cytology ; Plant Roots/drug effects ; Plant Roots/genetics ; Polyadenylation/drug effects ; Protein Biosynthesis/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing.
Autorzy :
Vo TV; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Dhakshnamoorthy J; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Larkin M; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Zofall M; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Thillainadesan G; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Balachandran V; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Holla S; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Wheeler D; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Grewal SIS; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Jul 02; Vol. 28 (1), pp. 267-281.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
Gene Silencing*
Transcription Termination, Genetic*
Heterochromatin/*metabolism
RNA Polymerase II/*metabolism
Schizosaccharomyces/*genetics
Schizosaccharomyces pombe Proteins/*metabolism
mRNA Cleavage and Polyadenylation Factors/*metabolism
Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Chromatin Assembly and Disassembly/genetics ; Exoribonucleases/genetics ; Exoribonucleases/metabolism ; Gene Expression Regulation, Fungal ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Meiosis/genetics ; Phosphoprotein Phosphatases/genetics ; Phosphoprotein Phosphatases/metabolism ; RNA Interference ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
HIV-1 is more dependent on the K182 capsid residue than HIV-2 for interactions with CPSF6.
Autorzy :
Saito A; Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. Electronic address: .
Ode H; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Nohata K; Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Ohmori H; Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Nakayama EE; Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Iwatani Y; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan; Division of Basic Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shioda T; Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
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Źródło :
Virology [Virology] 2019 Jun; Vol. 532, pp. 118-126. Date of Electronic Publication: 2019 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Capsid/*metabolism
HIV-1/*genetics
HIV-2/*genetics
mRNA Cleavage and Polyadenylation Factors/*chemistry
Amino Acid Sequence ; Amino Acid Substitution ; Binding Sites ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/virology ; Capsid/ultrastructure ; Cell Line ; Cell Nucleus/metabolism ; Cell Nucleus/virology ; Gene Expression ; Gene Expression Regulation ; HEK293 Cells ; HIV-1/growth & development ; HIV-1/metabolism ; HIV-2/growth & development ; HIV-2/metabolism ; Host-Pathogen Interactions ; Humans ; Models, Molecular ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Species Specificity ; Virus Replication ; mRNA Cleavage and Polyadenylation Factors/genetics ; mRNA Cleavage and Polyadenylation Factors/metabolism
Czasopismo naukowe
Tytuł :
CPEB1 Expression Correlates with Severity of Posttraumatic Ankle Osteoarthritis and Aggravates Catabolic Effect of IL-1β on Chondrocytes.
Autorzy :
Li L; Department of Orthopaedics, Suining Central Hospital, No. 27 Dongping North Road, Hedong New District, Suining, 629000, Sichuan, China. .
Lan J; Department of Orthopaedics, Suining Central Hospital, No. 27 Dongping North Road, Hedong New District, Suining, 629000, Sichuan, China.
Ye Y; Department of Orthopaedics, Suining Central Hospital, No. 27 Dongping North Road, Hedong New District, Suining, 629000, Sichuan, China.
Yang B; Department of Orthopaedics, Suining Central Hospital, No. 27 Dongping North Road, Hedong New District, Suining, 629000, Sichuan, China.
Yang X; Kunming General Hospital of Chinese PLA, Trauma Orthopedic Institute of Chinese PLA, Kunming, 650032, Yunnan, China.
Cai Z; Kunming General Hospital of Chinese PLA, Trauma Orthopedic Institute of Chinese PLA, Kunming, 650032, Yunnan, China.
Pokaż więcej
Źródło :
Inflammation [Inflammation] 2019 Apr; Vol. 42 (2), pp. 628-636.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-1beta/*pharmacology
Osteoarthritis/*pathology
Transcription Factors/*metabolism
mRNA Cleavage and Polyadenylation Factors/*metabolism
Ankle ; Cartilage, Articular ; Cells, Cultured ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Disease Progression ; Female ; Humans ; Inflammation Mediators ; Male ; Middle Aged ; Transcription Factors/drug effects ; Transcription Factors/pharmacology ; Tumor Necrosis Factor-alpha/pharmacology ; Up-Regulation ; Wounds and Injuries ; mRNA Cleavage and Polyadenylation Factors/drug effects ; mRNA Cleavage and Polyadenylation Factors/pharmacology
Czasopismo naukowe

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