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Tytuł :
Lipid accumulation in macrophages confers protumorigenic polarization and immunity in gastric cancer.
Autorzy :
Luo Q; Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Clinical Laboratory, Affiliated Dongguan People's Hospital, Southern Medical University, Dongguan, China.
Zheng N; Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiang L; Department of Gynecology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang T; Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang P; Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu Y; Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zheng P; Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Clinical Laboratory, Henan provincial people's Hospital, Zhengzhou, China.
Wang W; Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xie G; Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen L; Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li D; Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dong P; Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuan X; Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shen L; Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Źródło :
Cancer science [Cancer Sci] 2020 Nov; Vol. 111 (11), pp. 4000-4011. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article
MeSH Terms :
Lipid Metabolism*
Macrophage Activation/*immunology
Macrophages/*immunology
Macrophages/*metabolism
Stomach Neoplasms/*etiology
Stomach Neoplasms/*metabolism
Animals ; Cell Line, Tumor ; Cell Transformation, Neoplastic ; Disease Models, Animal ; Disease Susceptibility ; Female ; Fluorescent Antibody Technique ; Humans ; Immunophenotyping ; Lipidomics ; Macrophage Activation/genetics ; Mice ; Models, Biological ; Phagocytosis ; Phosphatidylinositol 3-Kinases/metabolism ; Stomach Neoplasms/pathology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocyte Subsets/pathology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/pathology
Czasopismo naukowe
Tytuł :
Phylloseptin-1 is Leishmanicidal for Amastigotes of Leishmania Inside Infected Macrophages.amazonensis Inside Infected Macrophages.
Autorzy :
Kückelhaus SAS; Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Área de Morfologia, Faculdade de Medicina, FM, Universidade de Brasília, Brasília, DF 70910900, Brazil.
Aquino DS; Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Área de Morfologia, Faculdade de Medicina, FM, Universidade de Brasília, Brasília, DF 70910900, Brazil.
Borges TK; Laboratório de Imunologia Celular, Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Faculdade de Medicina, FM, Universidade de Brasília, Brasília, DF 70910900, Brazil.
Moreira DC; Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Área de Morfologia, Faculdade de Medicina, FM, Universidade de Brasília, Brasília, DF 70910900, Brazil.
Leite LM; Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Área de Morfologia, Faculdade de Medicina, FM, Universidade de Brasília, Brasília, DF 70910900, Brazil.
Muniz-Junqueira MI; Laboratório de Imunologia Celular, Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Faculdade de Medicina, FM, Universidade de Brasília, Brasília, DF 70910900, Brazil.
Kückelhaus CS; Laboratório de Imunologia Celular, Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Faculdade de Medicina, FM, Universidade de Brasília, Brasília, DF 70910900, Brazil.
Romero GAS; Laboratório de Leishmaniose, Núcleo de Medicina Tropical, Universidade de Brasília, Brasília, DF 70910900, Brazil.
Prates MV; Laboratório de Espectrometria de Massa, LEM, EMBRAPA Recursos Genéticos e Biotecnologia, Brasília, DF 70770900, Brazil.
Bloch C Jr; Laboratório de Espectrometria de Massa, LEM, EMBRAPA Recursos Genéticos e Biotecnologia, Brasília, DF 70770900, Brazil.
Leite JRSA; Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Área de Morfologia, Faculdade de Medicina, FM, Universidade de Brasília, Brasília, DF 70910900, Brazil.; Bioprospectum, Lda, Parque Tecnológico da Universidade do Porto, UPTEC, 4200135 Porto, Portugal.
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Źródło :
International journal of environmental research and public health [Int J Environ Res Public Health] 2020 Jul 06; Vol. 17 (13). Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Leishmania*
Macrophages, Peritoneal*
Animals ; Female ; Macrophages ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł :
Selenium-independent antioxidant and anti-inflammatory effects of thioredoxin reductase inhibition in alveolar macrophages.
Autorzy :
Staples S; Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Wall SB; Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Li R; Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Tipple TE; Center for Pregnancy and Newborn Research, Section of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Oklahoma College of Medicine, Oklahoma City, OK, USA. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 15; Vol. 259, pp. 118285. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Auranofin/*pharmacology
Macrophages, Alveolar/*metabolism
Thioredoxin Reductase 1/*metabolism
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Auranofin/metabolism ; Bronchopulmonary Dysplasia/metabolism ; Bronchopulmonary Dysplasia/physiopathology ; Glutathione/metabolism ; Interleukin-1beta/drug effects ; Interleukin-1beta/metabolism ; Lipopolysaccharides/pharmacology ; Lung/metabolism ; Macrophages/metabolism ; Macrophages, Alveolar/physiology ; Mice ; Primary Cell Culture ; Selenium/metabolism ; Selenium/pharmacology ; Thioredoxin Reductase 1/antagonists & inhibitors ; Thioredoxin-Disulfide Reductase/antagonists & inhibitors ; Thioredoxin-Disulfide Reductase/metabolism
Czasopismo naukowe
Tytuł :
The Mincle/Syk/NF-κB Signaling Circuit Is Essential for Maintaining the Protumoral Activities of Tumor-Associated Macrophages.
Autorzy :
Li C; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Xue VW; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Shatin, Hong Kong.
Wang QM; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.
Lian GY; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.
Huang XR; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.; Guangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, China.
Lee TL; Reproduction, Development and Endocrinology Program, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.
To KF; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Shatin, Hong Kong.
Tang PM; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Shatin, Hong Kong. .
Lan HY; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong. .
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Źródło :
Cancer immunology research [Cancer Immunol Res] 2020 Aug; Vol. 8 (8), pp. 1004-1017. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lectins, C-Type/*metabolism
Lung Neoplasms/*immunology
Melanoma/*immunology
Membrane Proteins/*metabolism
NF-kappa B/*metabolism
Receptors, Immunologic/*metabolism
Syk Kinase/*metabolism
Tumor-Associated Macrophages/*immunology
Aged ; Animals ; Cell Line, Tumor ; Cytokines/immunology ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Humans ; Lectins, C-Type/immunology ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Macrophages/immunology ; Macrophages/pathology ; Male ; Melanoma/metabolism ; Melanoma/pathology ; Membrane Proteins/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, SCID ; Middle Aged ; NF-kappa B/immunology ; Receptors, Immunologic/immunology ; Signal Transduction ; Syk Kinase/immunology ; Tumor-Associated Macrophages/pathology
Czasopismo naukowe
Tytuł :
Cordyceps militaris polysaccharide converts immunosuppressive macrophages into M1-like phenotype and activates T lymphocytes by inhibiting the PD-L1/PD-1 axis between TAMs and T lymphocytes.
Autorzy :
Bi S; Department of Pharmacology, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Huang W; Biotechnological Institute of Chinese Materia Medica, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Chen S; Department of Natural Products Chemistry, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Huang C; Department of Natural Products Chemistry, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Li C; Department of Pharmacology, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Guo Z; Biotechnological Institute of Chinese Materia Medica, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Yang J; Department of Pharmacology, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Zhu J; Department of Natural Products Chemistry, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China. Electronic address: .
Song L; Department of Pharmacology, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China. Electronic address: .
Yu R; Biotechnological Institute of Chinese Materia Medica, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China; Department of Natural Products Chemistry, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 May 01; Vol. 150, pp. 261-280. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji :
Journal Article
MeSH Terms :
Cordyceps/*chemistry
Fungal Polysaccharides/*pharmacology
Lymphocyte Activation/*drug effects
Macrophages/*drug effects
Macrophages/*physiology
Signal Transduction/*drug effects
T-Lymphocytes/*drug effects
T-Lymphocytes/*physiology
Animals ; B7-H1 Antigen/metabolism ; Biomarkers ; Calcium/metabolism ; Cell Line ; Cytokines/metabolism ; Fungal Polysaccharides/chemistry ; Humans ; Immunomodulation ; Immunophenotyping ; Macrophage Activation/drug effects ; Macrophage Activation/immunology ; Mice ; Nitric Oxide/metabolism ; Programmed Cell Death 1 Receptor/metabolism ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/pathology
Czasopismo naukowe
Tytuł :
Pulmonary inflammatory response to influenza virus infection in pigs is regulated by DAP12 and macrophage M1 and M2 phenotypes.
Autorzy :
Hiremath J; Food Animal Health Research Program, College of Food, Agricultural and Environmental Sciences, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH, USA; ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, Karnataka, India.
Renu S; Food Animal Health Research Program, College of Food, Agricultural and Environmental Sciences, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH, USA.
Tabynov K; Kazakh National Agrarian University, Almaty 050010, Kazakhstan and Research Institute of Cardiology and Internal Medicine, Almaty 050000, Kazakhstan.
Renukaradhya GJ; Food Animal Health Research Program, College of Food, Agricultural and Environmental Sciences, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH, USA. Electronic address: .
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Źródło :
Cellular immunology [Cell Immunol] 2020 Jun; Vol. 352, pp. 104078. Date of Electronic Publication: 2020 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adaptor Proteins, Signal Transducing/*immunology
Macrophages, Alveolar/*immunology
Membrane Proteins/*immunology
Orthomyxoviridae Infections/*immunology
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Biomarkers/metabolism ; Cytokines/metabolism ; Female ; Influenza A virus/immunology ; Influenza A virus/pathogenicity ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages, Alveolar/metabolism ; Male ; Membrane Proteins/metabolism ; Monocytes/metabolism ; Orthomyxoviridae/metabolism ; Phenotype ; Signal Transduction ; Swine/immunology ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Cultured macrophages transfer surplus cholesterol into adjacent cells in the absence of serum or high-density lipoproteins.
Autorzy :
He C; Department of Medicine, University of California, Los Angeles, CA 90095.
Jiang H; School of Molecular Sciences, University of Western Australia, 6009 Perth, Australia.
Song W; Department of Medicine, University of California, Los Angeles, CA 90095.
Riezman H; Department of Biochemistry, University of Geneva, CH-1211 Geneva 4, Switzerland.; National Centre of Competence in Research, Chemical Biology, University of Geneva, CH-1211 Geneva 4, Switzerland.
Tontonoz P; Department of Human Genetics, University of California, Los Angeles, CA 90095.
Weston TA; Department of Medicine, University of California, Los Angeles, CA 90095.
Guagliardo P; Centre for Microscopy, Characterisation and Analysis, University of Western Australia, 6009 Perth, Australia.
Kim PH; Department of Medicine, University of California, Los Angeles, CA 90095.
Jung R; Department of Medicine, University of California, Los Angeles, CA 90095.
Heizer P; Department of Medicine, University of California, Los Angeles, CA 90095.
Fong LG; Department of Medicine, University of California, Los Angeles, CA 90095; .
Young SG; Department of Medicine, University of California, Los Angeles, CA 90095; .; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 May 12; Vol. 117 (19), pp. 10476-10483. Date of Electronic Publication: 2020 Apr 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
ATP Binding Cassette Transporter 1/*metabolism
Cholesterol/*metabolism
Macrophages/*metabolism
ATP Binding Cassette Transporter 1/physiology ; ATP-Binding Cassette Transporters/metabolism ; Animals ; Atherosclerosis/metabolism ; Atherosclerosis/physiopathology ; Biological Transport ; Foam Cells/metabolism ; Lipid Metabolism ; Lipoproteins, HDL/metabolism ; Macrophages/physiology ; Macrophages, Peritoneal/metabolism ; Mice ; Mice, Inbred C57BL ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Serum/metabolism ; beta-Cyclodextrins/metabolism
Czasopismo naukowe
Tytuł :
CD71 Alveolar Macrophages in Idiopathic Pulmonary Fibrosis: A Look beyond the Borders of the Disease.
Autorzy :
Puxeddu E; University of Rome Tor VergataRome, Italyand.
Fraboni D; University Hospital Tor VergataRome, Italy.
Cillis G; University of Rome Tor VergataRome, Italyand.
Cavalli F; University of Rome Tor VergataRome, Italyand.
Buccisano F; University of Rome Tor VergataRome, Italyand.
Rogliani P; University of Rome Tor VergataRome, Italyand.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2019 Dec 01; Vol. 200 (11), pp. 1444-1446.
Typ publikacji :
Letter; Comment
MeSH Terms :
Idiopathic Pulmonary Fibrosis*
Macrophages, Alveolar*
Humans ; Macrophages ; Receptors, Transferrin
Opinia redakcyjna
Tytuł :
Reply to Puxeddu et al. : CD71 Alveolar Macrophages in Idiopathic Pulmonary Fibrosis: A Look beyond the Borders of the Disease.
Autorzy :
Byrne A; Imperial College LondonLondon, United Kingdom.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2019 Dec 01; Vol. 200 (11), pp. 1446-1447.
Typ publikacji :
Letter; Comment
MeSH Terms :
Idiopathic Pulmonary Fibrosis*
Macrophages, Alveolar*
Humans ; Macrophages ; Receptors, Transferrin
Opinia redakcyjna
Tytuł :
Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis.
Autorzy :
Roquilly A; Université de Nantes, EA3826 Thérapeutiques Anti-Infectieuses, Institut de Recherche en Santé 2 Nantes Biotech, Nantes, France. .; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, France. .; Department of Microbiology and Immunology, Peter Doherty Institute of Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia. .
Jacqueline C; Université de Nantes, EA3826 Thérapeutiques Anti-Infectieuses, Institut de Recherche en Santé 2 Nantes Biotech, Nantes, France.
Davieau M; Université de Nantes, EA3826 Thérapeutiques Anti-Infectieuses, Institut de Recherche en Santé 2 Nantes Biotech, Nantes, France.
Mollé A; Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR1064, ITUN, Nantes, France.
Sadek A; Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR1064, ITUN, Nantes, France.; Department of Biology, Faculty of Science, Moulay Ismail University, Zitoune, Meknes, Morocco.
Fourgeux C; Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR1064, ITUN, Nantes, France.
Rooze P; Université de Nantes, EA3826 Thérapeutiques Anti-Infectieuses, Institut de Recherche en Santé 2 Nantes Biotech, Nantes, France.; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, France.
Broquet A; Université de Nantes, EA3826 Thérapeutiques Anti-Infectieuses, Institut de Recherche en Santé 2 Nantes Biotech, Nantes, France.
Misme-Aucouturier B; Université de Nantes, EA3826 Thérapeutiques Anti-Infectieuses, Institut de Recherche en Santé 2 Nantes Biotech, Nantes, France.
Chaumette T; Université de Nantes, EA3826 Thérapeutiques Anti-Infectieuses, Institut de Recherche en Santé 2 Nantes Biotech, Nantes, France.
Vourc'h M; Université de Nantes, EA3826 Thérapeutiques Anti-Infectieuses, Institut de Recherche en Santé 2 Nantes Biotech, Nantes, France.; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, France.
Cinotti R; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, France.
Marec N; Plateforme Cytocell, SFR François Bonamy, Nantes, France.
Gauttier V; Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR1064, ITUN, Nantes, France.
McWilliam HEG; Department of Microbiology and Immunology, Peter Doherty Institute of Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.
Altare F; CRCINA, INSERM, Université de Nantes, CHU de Nantes, Nantes, France.
Poschmann J; Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR1064, ITUN, Nantes, France. .
Villadangos JA; Department of Microbiology and Immunology, Peter Doherty Institute of Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia. .; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia. .
Asehnoune K; Université de Nantes, EA3826 Thérapeutiques Anti-Infectieuses, Institut de Recherche en Santé 2 Nantes Biotech, Nantes, France. .; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, France. .
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Źródło :
Nature immunology [Nat Immunol] 2020 Jun; Vol. 21 (6), pp. 636-648. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Inflammation/*etiology
Lung/*immunology
Lung/*metabolism
Macrophages, Alveolar/*metabolism
Animals ; Biomarkers ; Cellular Reprogramming ; Cytokines/metabolism ; Humans ; Immune Tolerance ; Immunophenotyping ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Lung/pathology ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages, Alveolar/immunology ; Mice ; Monocytes/immunology ; Monocytes/metabolism ; Phagocytosis/immunology ; Pneumonia/etiology ; Pneumonia/metabolism ; Pneumonia/pathology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
Czasopismo naukowe
Tytuł :
MALDI-MSI spatially maps N-glycan alterations to histologically distinct pulmonary pathologies following irradiation.
Autorzy :
Carter CL; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA.
Parker GA; Pathology Associates, Charles River Laboratories, Raleigh-Durham, NC, USA.
Hankey KG; Department of Radiation Oncology, School of Medicine, University of Maryland, Maryland, USA.
Farese AM; Department of Radiation Oncology, School of Medicine, University of Maryland, Maryland, USA.
MacVittie TJ; Department of Radiation Oncology, School of Medicine, University of Maryland, Maryland, USA.
Kane MA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 14; Vol. 10 (1), pp. 11559. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Lung/*radiation effects
Lung Injury/*microbiology
Macrophages, Alveolar/*radiation effects
Polysaccharides/*chemistry
Radiation Injuries/*metabolism
Animals ; Edema/metabolism ; Glycosylation ; Inflammation ; Macaca mulatta ; Macrophages ; Male ; Mannose ; Phenotype ; Pneumonia/metabolism ; Pulmonary Fibrosis/metabolism ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Czasopismo naukowe
Tytuł :
Hyaloid Vasculature as a Major Source of STAT3 (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy.
Autorzy :
Hombrebueno JR; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).; Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (J.R.H.).
Lynch A; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Byrne EM; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Obasanmi G; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Kissenpfennig A; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Chen M; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Xu H; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Dec; Vol. 40 (12), pp. e367-e379. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oxygen*
Macrophages/*metabolism
Retinal Neovascularization/*metabolism
Retinal Vessels/*metabolism
Retinopathy of Prematurity/*metabolism
STAT3 Transcription Factor/*metabolism
Animals ; Animals, Newborn ; Anthraquinones/pharmacology ; Disease Models, Animal ; Female ; Macrophages/drug effects ; Macrophages/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation ; Retinal Neovascularization/etiology ; Retinal Neovascularization/pathology ; Retinal Neovascularization/prevention & control ; Retinal Vessels/drug effects ; Retinal Vessels/pathology ; Retinopathy of Prematurity/etiology ; Retinopathy of Prematurity/pathology ; Retinopathy of Prematurity/prevention & control ; STAT3 Transcription Factor/antagonists & inhibitors ; Signal Transduction ; Sulfonamides/pharmacology ; Suppressor of Cytokine Signaling 3 Protein/genetics ; Suppressor of Cytokine Signaling 3 Protein/metabolism
Czasopismo naukowe
Tytuł :
NADPH oxidase and mitochondria are relevant sources of superoxide anion in the oxinflammatory response of macrophages exposed to airborne particulate matter.
Autorzy :
Cáceres L; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Cátedra de Química General e Inorgánica, Argentina.
Paz ML; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología, Biotecnología y Genética, Cátedra de Inmunología, Argentina; CONICET - Universidad de Buenos Aires, Instituto de Estudios de la Inmunidad Humoral (IDEHU), Facultad de Farmacia y Bioquímica, Argentina.
Garcés M; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Cátedra de Química General e Inorgánica, Argentina.
Calabró V; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Cátedra de Química General e Inorgánica, Argentina; CONICET - Universidad de Buenos Aires, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Facultad de Farmacia y Bioquímica, Argentina.
Magnani ND; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Cátedra de Química General e Inorgánica, Argentina; CONICET - Universidad de Buenos Aires, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Facultad de Farmacia y Bioquímica, Argentina.
Martinefski M; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Tecnología Farmacéutica, Cátedra de Tecnología Farmacéutica I, Argentina.
Martino Adami PV; Laboratory of Brain Aging and Neurodegeneration, Fundación Instituto Leloir, IIBBA-CONICET, Argentina.
Caltana L; CONICET - Universidad de Buenos Aires, Instituto de Biología Celular y Neurociencia Prof. E. De Robertis (IBCN), Facultad de Medicina, Argentina.
Tasat D; Universidad Nacional de San Martín, Escuela de Ciencia y Tecnología, Centro de Estudios en Salud y Medio Ambiente, Argentina.
Morelli L; Laboratory of Brain Aging and Neurodegeneration, Fundación Instituto Leloir, IIBBA-CONICET, Argentina.
Tripodi V; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Tecnología Farmacéutica, Cátedra de Tecnología Farmacéutica I, Argentina.
Valacchi G; NC State University, Plants for Human Health Institute, Animal Science Department, USA; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
Alvarez S; CONICET - Universidad de Buenos Aires, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Facultad de Farmacia y Bioquímica, Argentina; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Cátedra de Fisicoquímica, Argentina.
González Maglio D; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología, Biotecnología y Genética, Cátedra de Inmunología, Argentina; CONICET - Universidad de Buenos Aires, Instituto de Estudios de la Inmunidad Humoral (IDEHU), Facultad de Farmacia y Bioquímica, Argentina.
Marchini T; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Cátedra de Química General e Inorgánica, Argentina; CONICET - Universidad de Buenos Aires, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Facultad de Farmacia y Bioquímica, Argentina.
Evelson P; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Cátedra de Química General e Inorgánica, Argentina; CONICET - Universidad de Buenos Aires, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Facultad de Farmacia y Bioquímica, Argentina. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 01; Vol. 205, pp. 111186. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article
MeSH Terms :
Macrophages, Alveolar/*drug effects
Mitochondria/*drug effects
NADPH Oxidases/*metabolism
Oxidative Stress/*drug effects
Particulate Matter/*toxicity
Superoxides/*metabolism
Air Pollutants/toxicity ; Animals ; Antioxidants/metabolism ; Coal Ash/toxicity ; Hydrogen Peroxide/metabolism ; Inflammation ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/metabolism ; Mice ; Mitochondria/immunology ; Mitochondria/metabolism ; Oxidation-Reduction ; Oxidative Stress/immunology ; RAW 264.7 Cells ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Irradiated and CCl 4 -treated bone marrow-derived liver macrophages exhibit different gene expression patterns and phenotypes.
Autorzy :
Fan X; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Shan S; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Wu P; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Lin W; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Jia J; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
He F; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
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Źródło :
Scandinavian journal of immunology [Scand J Immunol] 2020 Nov; Vol. 92 (5), pp. e12916. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Marrow Cells/*metabolism
Gene Expression Profiling/*methods
Liver/*cytology
Macrophages/*metabolism
Animals ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/radiation effects ; Carbon Tetrachloride/toxicity ; Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Cell Differentiation/radiation effects ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Proliferation/radiation effects ; Cells, Cultured ; Gene Ontology ; Liver/drug effects ; Liver/radiation effects ; Liver Failure, Acute/chemically induced ; Liver Failure, Acute/genetics ; Liver Failure, Acute/metabolism ; Macrophages/drug effects ; Macrophages/radiation effects ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Phenotype ; Radiation Injuries, Experimental/genetics ; Radiation Injuries, Experimental/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Baohuoside i suppresses breast cancer metastasis by downregulating the tumor-associated macrophages/C-X-C motif chemokine ligand 1 pathway.
Autorzy :
Wang S; Integrative Research Laboratory of Breast Cancer, the Research Center for Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine & the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Wang N; Integrative Research Laboratory of Breast Cancer, the Research Center for Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine & the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, Guangdong, China; College of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Huang X; Integrative Research Laboratory of Breast Cancer, the Research Center for Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine & the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, Guangdong, China; College of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Yang B; Integrative Research Laboratory of Breast Cancer, the Research Center for Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine & the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Zheng Y; Integrative Research Laboratory of Breast Cancer, the Research Center for Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine & the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Zhang J; Integrative Research Laboratory of Breast Cancer, the Research Center for Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine & the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Wang X; Integrative Research Laboratory of Breast Cancer, the Research Center for Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine & the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Lin Y; Integrative Research Laboratory of Breast Cancer, the Research Center for Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine & the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Wang Z; Integrative Research Laboratory of Breast Cancer, the Research Center for Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine & the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, Guangdong, China; College of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2020 Nov; Vol. 78, pp. 153331. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*drug therapy
Breast Neoplasms/*pathology
Chemokine CXCL1/*metabolism
Flavonoids/*pharmacology
Macrophages/*drug effects
Animals ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Chemokine CXCL1/antagonists & inhibitors ; Chemokine CXCL1/genetics ; Coculture Techniques ; Down-Regulation/drug effects ; Drug Screening Assays, Antitumor ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Embryo, Nonmammalian ; Female ; Humans ; Macrophages/metabolism ; Macrophages/pathology ; Mice, Inbred BALB C ; Neoplasm Metastasis ; Neoplastic Stem Cells/drug effects ; Xenograft Model Antitumor Assays ; Zebrafish/embryology
Czasopismo naukowe
Tytuł :
Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis.
Autorzy :
Chen S; School of Medicine, Hunan Normal University, Changsha, Hunan Province 410013, PR China.
Tan S; School of Medicine, Hunan Normal University, Changsha, Hunan Province 410013, PR China.
Yang S; School of Medicine, Hunan Normal University, Changsha, Hunan Province 410013, PR China.
Chen G; Department of Pneumoconiosis, Beidaihe Sanitarium for China Coal Miners, Qinhuangdao, Hebei Province 066104, PR China.
Zhu L; Department of Pneumoconiosis, Beidaihe Sanitarium for China Coal Miners, Qinhuangdao, Hebei Province 066104, PR China.
Sun Z; Department of Pneumoconiosis, Beidaihe Sanitarium for China Coal Miners, Qinhuangdao, Hebei Province 066104, PR China.
Li H; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Yao S; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Nov 01; Vol. 334, pp. 94-101. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Autophagy/*drug effects
Macrophages, Alveolar/*drug effects
Nicotine/*toxicity
Silicosis/*pathology
Adenine/analogs & derivatives ; Adenine/pharmacology ; Caspase 3/metabolism ; Cells, Cultured ; Humans ; In Situ Nick-End Labeling ; Lysosomes/drug effects ; Lysosomes/metabolism ; Lysosomes/pathology ; Macrophages, Alveolar/metabolism ; Macrophages, Alveolar/pathology ; Male ; Microtubule-Associated Proteins/metabolism ; Silicon Dioxide/toxicity ; Silicosis/metabolism
Czasopismo naukowe
Tytuł :
Enhanced expression of coxsackievirus and adenovirus receptor in lipopolysaccharide-induced inflammatory macrophages is through TRIF-dependent innate immunity pathway.
Autorzy :
Lin CH; Department of Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan.
Chang YC; Department of Surgery, MacKay Memorial Hospital, Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.
Chang TK; Department of Surgery, MacKay Memorial Hospital, Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; Department of Orthopedics, MacKay Memorial Hospital, New Taipei City, Taiwan.
Huang CH; Department of Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan; Department of Surgery, MacKay Memorial Hospital, Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.
Lu YC; Department of Surgery, MacKay Memorial Hospital, Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; Department of Orthopedics, MacKay Memorial Hospital, New Taipei City, Taiwan.
Huang CH; Department of Surgery, MacKay Memorial Hospital, Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; Department of Orthopedics, MacKay Memorial Hospital, New Taipei City, Taiwan.
Chen MJ; Department of Surgery, MacKay Memorial Hospital, Department of Medicine, MacKay Medical College, New Taipei City, Taiwan. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118832. Date of Electronic Publication: 2020 Nov 28.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Vesicular Transport/*metabolism
Coxsackie and Adenovirus Receptor-Like Membrane Protein/*genetics
Immunity, Innate/*immunology
Inflammation/*pathology
Macrophages/*pathology
Adenoviridae/genetics ; Animals ; Cell Line ; Genetic Vectors/administration & dosage ; Inflammation/genetics ; Inflammation/immunology ; Interferon Regulatory Factor-3/metabolism ; Lipopolysaccharides ; Macrophages/immunology ; Male ; Mice ; RAW 264.7 Cells ; Rats ; Rats, Sprague-Dawley ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages.
Autorzy :
Anil SM; Institute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Shalev N; Institute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Vinayaka AC; Institute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Nadarajan S; Institute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Namdar D; Institute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Belausov E; Institute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Shoval I; The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 5290002, Ramat Gan, Israel.
Mani KA; Institute for Postharvest and Food Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Mechrez G; Institute for Postharvest and Food Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Koltai H; Institute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jan 14; Vol. 11 (1), pp. 1462. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
COVID-19/*immunology
Cannabinoids/*pharmacology
Cannabis/*chemistry
Epithelial Cells/*immunology
Macrophages/*immunology
Plant Extracts/*pharmacology
SARS-CoV-2/*immunology
A549 Cells ; Angiotensin-Converting Enzyme 2/immunology ; Anti-Inflammatory Agents/chemistry ; COVID-19/drug therapy ; COVID-19/pathology ; Cannabinoids/chemistry ; Cytokines/immunology ; Epithelial Cells/pathology ; Epithelial Cells/virology ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/immunology ; Humans ; Macrophages/pathology ; Macrophages/virology ; Plant Extracts/chemistry ; Receptors, IgG/immunology
Czasopismo naukowe
Tytuł :
Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells.
Autorzy :
Muñoz-Rojas AR; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Department of Immunology, Harvard Medical School, Boston, MA, USA.
Kelsey I; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Pappalardo JL; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Chen M; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Miller-Jensen K; Department of Biomedical Engineering, Yale University, New Haven, CT, USA. .; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA. .; Systems Biology Institute, Yale University, New Haven, CT, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 12; Vol. 12 (1), pp. 301. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Polarity*/drug effects
Cell Polarity*/genetics
Macrophages/*cytology
Animals ; Arginase/metabolism ; Female ; Gene Expression Regulation/drug effects ; Interferon-gamma/pharmacology ; Interleukin-12/metabolism ; Interleukin-6/metabolism ; Lipopolysaccharides/pharmacology ; Machine Learning ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice, Inbred C57BL ; Neural Networks, Computer ; Odds Ratio ; Single-Cell Analysis ; Transcription Factors/metabolism ; Transcription, Genetic/drug effects
Czasopismo naukowe

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