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Tytuł:
Targeting Group 3 Medulloblastoma by the Anti-PRUNE-1 and Anti-LSD1/KDM1A Epigenetic Molecules.
Autorzy:
Bibbò F; Department of Molecular Medicine and Medical Biotechnological DMMBM, University Federico II of Naples, 80131 Naples, Italy.; CEINGE Biotecnologie Avanzate 'Franco Salvatore', 80131 Naples, Italy.
Asadzadeh F; CEINGE Biotecnologie Avanzate 'Franco Salvatore', 80131 Naples, Italy.; SEMM European School of Molecular Medicine, 20139 Milan, Italy.
Boccia A; CEINGE Biotecnologie Avanzate 'Franco Salvatore', 80131 Naples, Italy.
Sorice C; CEINGE Biotecnologie Avanzate 'Franco Salvatore', 80131 Naples, Italy.
Bianco O; CEINGE Biotecnologie Avanzate 'Franco Salvatore', 80131 Naples, Italy.
Saccà CD; Department of Biology, University Federico II of Naples, 80138 Naples, Italy.
Majello B; Department of Biology, University Federico II of Naples, 80138 Naples, Italy.
Donofrio V; Department of Pathology, Santobono-Pausilipon Children's Hospital, AORN, 80129 Naples, Italy.
Bifano D; Department of Pathology, Santobono-Pausilipon Children's Hospital, AORN, 80129 Naples, Italy.
De Martino L; Pediatric Neuro-Oncology, Santobono-Pausilipon Children's Hospital, AORN, 80129 Naples, Italy.
Quaglietta L; Pediatric Neuro-Oncology, Santobono-Pausilipon Children's Hospital, AORN, 80129 Naples, Italy.
Cristofano A; Pediatric Neuroradiology, Santobono-Pausilipon Children's Hospital, AORN, 80129 Naples, Italy.
Covelli EM; Pediatric Neuroradiology, Santobono-Pausilipon Children's Hospital, AORN, 80129 Naples, Italy.
Cinalli G; Pediatric Neurosurgery, Santobono-Pausilipon Children's Hospital, AORN, 80129 Naples, Italy.
Ferrucci V; Department of Molecular Medicine and Medical Biotechnological DMMBM, University Federico II of Naples, 80131 Naples, Italy.; CEINGE Biotecnologie Avanzate 'Franco Salvatore', 80131 Naples, Italy.
De Antonellis P; Department of Molecular Medicine and Medical Biotechnological DMMBM, University Federico II of Naples, 80131 Naples, Italy.; CEINGE Biotecnologie Avanzate 'Franco Salvatore', 80131 Naples, Italy.
Zollo M; Department of Molecular Medicine and Medical Biotechnological DMMBM, University Federico II of Naples, 80131 Naples, Italy.; CEINGE Biotecnologie Avanzate 'Franco Salvatore', 80131 Naples, Italy.; DAI Medicina di Laboratorio e Trasfusionale, 'AOU Federico II Policlinico', 80131 Naples, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 31; Vol. 25 (7). Date of Electronic Publication: 2024 Mar 31.
Typ publikacji:
Journal Article
MeSH Terms:
Medulloblastoma*/drug therapy
Medulloblastoma*/genetics
Brain Neoplasms*
Cerebellar Neoplasms*
Humans ; Child ; Histone Demethylases/genetics ; Epigenesis, Genetic ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Diagnostic Utility of GATA3 and ISL1 in Differentiating Neuroblastoma From Other Pediatric Malignant Small Round Blue Cell Tumors.
Autorzy:
Mohanty SK; Department of Pathology and Laboratory Medicine, Advanced Medical Research Institute, Bhubaneswar, Odisha, India.; Department of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, Delhi, India.
Diwaker P; Department of Pathology, University College of Medical Sciences, Delhi, India.
Mishra SK; Department of Medical Oncology, Advanced Medical Research Institute, Bhubaneswar, Odisha, India.
Jha S; Department of Pathology and Laboratory Medicine, Advanced Medical Research Institute, Bhubaneswar, Odisha, India.
Lobo A; Department of Pathology and Laboratory Medicine, Advanced Medical Research Institute, Bhubaneswar, Odisha, India.
Panda SP; Department of Pediatric Oncology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.
Sharma S; Department of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, Delhi, India.
Kumar M; Department of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, Delhi, India.
Arora S; Department of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, Delhi, India.
Mallik V; Department of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, Delhi, India.
Jain D; Department of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, Delhi, India.
Jain E; Department of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, Delhi, India.
Chakrabarti I; Department of Pathology, AIIMS, Kalyani, West Bengal, India.
Varshney J; Department of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, Delhi, India.
Beg A; Department of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, Delhi, India.
Dixit M; Department of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, Delhi, India.
Baisakh MR; Department of Pathology, Prolife Diagnostics, Bhubaneswar, Odisha, India.
Naik S; Department of Pathology, Prolife Diagnostics, Bhubaneswar, Odisha, India.
Sahoo SK; Department of Pediatric Surgery, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.
Akgul M; Department of Pathology, Albany Medical Center, Albany, NY, USA.
Balzer BL; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Amin MB; Department of Pathology and Laboratory, University of Southern California Keck School, Los Angeles, CA, USA.
Parwani AV; Department of Pathology and Laboratory, Wexner Medical Center, Pathology, Columbus, OH, USA.
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Źródło:
International journal of surgical pathology [Int J Surg Pathol] 2024 Apr; Vol. 32 (2), pp. 294-303. Date of Electronic Publication: 2023 Jun 13.
Typ publikacji:
Journal Article
MeSH Terms:
Medulloblastoma*
Sarcoma, Synovial*/diagnosis
Sarcoma, Synovial*/genetics
Rhabdomyosarcoma, Embryonal*
Neuroblastoma*/diagnosis
Wilms Tumor*/diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Cerebellar Neoplasms*
Kidney Neoplasms*/diagnosis
Kidney Neoplasms*/genetics
Humans ; Child ; Biomarkers, Tumor ; Diagnosis, Differential ; GATA3 Transcription Factor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Marinopyrrole derivative MP1 as a novel anti-cancer agent in group 3 MYC-amplified Medulloblastoma.
Autorzy:
Coulter DW; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Chhonker YS; Department of Pharmacy Practice & Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Kumar D; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Kesherwani V; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Aldhafiri WN; Department of Pharmacy Practice & Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
McIntyre EM; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Alexander G; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Ray S; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Joshi SS; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Li R; Department of Pharmacy Practice & Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Murry DJ; Department of Pharmacy Practice & Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Chaturvedi NK; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Department of Pediatrics, Hematology and Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Jan 11; Vol. 43 (1), pp. 18. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Medulloblastoma*/drug therapy
Medulloblastoma*/genetics
Cerebellar Neoplasms*/drug therapy
Cerebellar Neoplasms*/genetics
Sirolimus/*analogs & derivatives
Humans ; Animals ; Mice ; G2 Phase Cell Cycle Checkpoints ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular and functional profiling of chemotolerant cells unveils nucleoside metabolism-dependent vulnerabilities in medulloblastoma.
Autorzy:
Mariotto E; Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.; Pediatric Research Institute, Corso Stati Uniti 4, 35127, Padua, Italy.; Unit of Biostatistics, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova, Via Loredan 18, 35131, Padua, Italy.
Rampazzo E; Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy. .; Pediatric Research Institute, Corso Stati Uniti 4, 35127, Padua, Italy. .
Bortolozzi R; Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy. .; Pediatric Research Institute, Corso Stati Uniti 4, 35127, Padua, Italy. .; Section of Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Meneghetti 2, 35131, Padua, Italy. .
Rruga F; Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.; Pediatric Research Institute, Corso Stati Uniti 4, 35127, Padua, Italy.
Zeni I; Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.
Manfreda L; Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.; Pediatric Research Institute, Corso Stati Uniti 4, 35127, Padua, Italy.
Marchioro C; Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.; Pediatric Research Institute, Corso Stati Uniti 4, 35127, Padua, Italy.
Canton M; Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.; Pediatric Research Institute, Corso Stati Uniti 4, 35127, Padua, Italy.
Cani A; Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.; Pediatric Research Institute, Corso Stati Uniti 4, 35127, Padua, Italy.
Magni R; Center for Applied Proteomics and Molecular Medicine, George Mason University, 10920 George Mason Circle, MSN 1A9, Manassas, VA, 20110, USA.
Luchini A; Center for Applied Proteomics and Molecular Medicine, George Mason University, 10920 George Mason Circle, MSN 1A9, Manassas, VA, 20110, USA.
Bresolin S; Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.; Pediatric Research Institute, Corso Stati Uniti 4, 35127, Padua, Italy.
Viola G; Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.; Pediatric Research Institute, Corso Stati Uniti 4, 35127, Padua, Italy.
Persano L; Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.; Pediatric Research Institute, Corso Stati Uniti 4, 35127, Padua, Italy.
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Nov 17; Vol. 11 (1), pp. 183. Date of Electronic Publication: 2023 Nov 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Medulloblastoma*/drug therapy
Medulloblastoma*/genetics
Medulloblastoma*/metabolism
Brain Neoplasms*
Cerebellar Neoplasms*/drug therapy
Cerebellar Neoplasms*/genetics
Cerebellar Neoplasms*/metabolism
Child ; Humans ; Nucleosides/pharmacology ; Nucleosides/therapeutic use ; Proteomics ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
miRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4.
Autorzy:
Yuan M; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, 1650 Orleans St., Baltimore, MD, 21231, USA.; Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL, 33701, USA.
Mahmud I; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Katsushima K; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, 1650 Orleans St., Baltimore, MD, 21231, USA.; Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL, 33701, USA.
Joshi K; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, 1650 Orleans St., Baltimore, MD, 21231, USA.; Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL, 33701, USA.
Saulnier O; The Arthur and Sonia Labatt Brain Tumour Research Centre and the Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Pokhrel R; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, 1650 Orleans St., Baltimore, MD, 21231, USA.; Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL, 33701, USA.
Lee B; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, 1650 Orleans St., Baltimore, MD, 21231, USA.; Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL, 33701, USA.
Liyanage W; Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Kunhiraman H; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, 1650 Orleans St., Baltimore, MD, 21231, USA.; Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL, 33701, USA.
Stapleton S; Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL, 33701, USA.
Gonzalez-Gomez I; Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL, 33701, USA.
Kannan RM; Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Eisemann T; National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Kolanthai E; Advanced Materials Processing and Analysis Centre, Nanoscience Technology Center, Materials Science and Engineering, College of Medicine, University of Central Florida, Orlando, FL, 32826, USA.
Seal S; Advanced Materials Processing and Analysis Centre, Nanoscience Technology Center, Materials Science and Engineering, College of Medicine, University of Central Florida, Orlando, FL, 32826, USA.
Garrett TJ; Department Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Abbasi S; Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Bockley K; Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, 21205, USA.
Hanes J; Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, 21205, USA.
Chapagain P; Department of Physics, Florida International University, Miami, FL, 33199, USA.
Jallo G; Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL, 33701, USA.
Wechsler-Reya RJ; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, 10032, USA.
Taylor MD; The Arthur and Sonia Labatt Brain Tumour Research Centre and the Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Texas Children's Cancer Center, Hematology-Oncology Section, Houston, TX, 77030, USA.; Department of Pediatrics-Hematology/Oncology and Neurosurgery, Baylor College of Medicine, Houston, TX, 77030, USA.
Eberhart CG; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Ray A; Riggs School of Applied Life Sciences, Keck Graduate Institute, Claremont, CA, 91711, USA.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Perera RJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, 1650 Orleans St., Baltimore, MD, 21231, USA. .; Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL, 33701, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Dec 19; Vol. 11 (1), pp. 203. Date of Electronic Publication: 2023 Dec 19.
Typ publikacji:
Journal Article
MeSH Terms:
Cerebellar Neoplasms*/metabolism
Medulloblastoma*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Animals ; Humans ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Homeostasis ; Ligases/genetics ; Ligases/metabolism ; Quality of Life
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice.
Autorzy:
Göbel C; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, 20251, Germany.; Research Institute Children's Cancer Center Hamburg, Martinistrasse 52, Building N63 (LIV), Hamburg, D-20251, Germany.
Godbole S; Center for Molecular Neurobiology, Falkenried 94, Hamburg, 20251, Germany.
Schoof M; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, 20251, Germany.; Research Institute Children's Cancer Center Hamburg, Martinistrasse 52, Building N63 (LIV), Hamburg, D-20251, Germany.
Holdhof D; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, 20251, Germany.; Research Institute Children's Cancer Center Hamburg, Martinistrasse 52, Building N63 (LIV), Hamburg, D-20251, Germany.
Kresbach C; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, 20251, Germany.; Research Institute Children's Cancer Center Hamburg, Martinistrasse 52, Building N63 (LIV), Hamburg, D-20251, Germany.; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, 20251, Germany.
Loose C; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, 20251, Germany.; Research Institute Children's Cancer Center Hamburg, Martinistrasse 52, Building N63 (LIV), Hamburg, D-20251, Germany.
Neumann J; Center for Molecular Neurobiology, Falkenried 94, Hamburg, 20251, Germany.; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, 20251, Germany.
Schüller U; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, 20251, Germany. .; Research Institute Children's Cancer Center Hamburg, Martinistrasse 52, Building N63 (LIV), Hamburg, D-20251, Germany. .; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, 20251, Germany. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Nov 02; Vol. 11 (1), pp. 174. Date of Electronic Publication: 2023 Nov 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Neoplasms*/genetics
Cerebellar Neoplasms*/metabolism
Medulloblastoma*/metabolism
Animals ; Humans ; Mice ; DNA Helicases/genetics ; Hedgehog Proteins/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Transcription Factors/genetics ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
mRNA-based precision targeting of neoantigens and tumor-associated antigens in malignant brain tumors.
Autorzy:
Trivedi V; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
Yang C; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
Klippel K; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
Yegorov O; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
von Roemeling C; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
Hoang-Minh L; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
Fenton G; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
Ogando-Rivas E; Boston Medical Center, Boston, MA, USA.
Castillo P; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
Moore G; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
Long-James K; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
Dyson K; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
Doonan B; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
Flores C; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA.
Mitchell DA; University of Florida, 1333 Center Drive, BSB B1-118, Gainesville, FL, 32610, USA. .
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Źródło:
Genome medicine [Genome Med] 2024 Jan 25; Vol. 16 (1), pp. 17. Date of Electronic Publication: 2024 Jan 25.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Neoplasms*/genetics
Brain Neoplasms*/therapy
Medulloblastoma*
Cancer Vaccines*/genetics
Cerebellar Neoplasms*
Humans ; Animals ; Mice ; mRNA Vaccines ; Antigens, Neoplasm/genetics ; Tumor Microenvironment/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neurodegeneration-associated protein VAPB regulates proliferation in medulloblastoma.
Autorzy:
Faria Assoni A; Human Genome and Stem Cell Research Center, Institute of Biosciences, University of São Paulo, 106, Rua do Matão, Cidade Universitária, São Paulo, 05508-090, Brazil. .; European Research Institute for the Biology of Ageing, University of Groningen, 1, Antonius Deusinglaan, 9713 AV, Groningen, The Netherlands. .
Giove Mitsugi T; Human Genome and Stem Cell Research Center, Institute of Biosciences, University of São Paulo, 106, Rua do Matão, Cidade Universitária, São Paulo, 05508-090, Brazil.
Wardenaar R; European Research Institute for the Biology of Ageing, University of Groningen, 1, Antonius Deusinglaan, 9713 AV, Groningen, The Netherlands.
Oliveira Ferreira R; Human Genome and Stem Cell Research Center, Institute of Biosciences, University of São Paulo, 106, Rua do Matão, Cidade Universitária, São Paulo, 05508-090, Brazil.
Farias Jandrey EH; Human Genome and Stem Cell Research Center, Institute of Biosciences, University of São Paulo, 106, Rua do Matão, Cidade Universitária, São Paulo, 05508-090, Brazil.
Machado Novaes G; Human Genome and Stem Cell Research Center, Institute of Biosciences, University of São Paulo, 106, Rua do Matão, Cidade Universitária, São Paulo, 05508-090, Brazil.
Fonseca de Oliveira Granha I; Human Genome and Stem Cell Research Center, Institute of Biosciences, University of São Paulo, 106, Rua do Matão, Cidade Universitária, São Paulo, 05508-090, Brazil.
Bakker P; European Research Institute for the Biology of Ageing, University of Groningen, 1, Antonius Deusinglaan, 9713 AV, Groningen, The Netherlands.
Kaid C; Human Genome and Stem Cell Research Center, Institute of Biosciences, University of São Paulo, 106, Rua do Matão, Cidade Universitária, São Paulo, 05508-090, Brazil.
Zatz M; Human Genome and Stem Cell Research Center, Institute of Biosciences, University of São Paulo, 106, Rua do Matão, Cidade Universitária, São Paulo, 05508-090, Brazil.
Foijer F; European Research Institute for the Biology of Ageing, University of Groningen, 1, Antonius Deusinglaan, 9713 AV, Groningen, The Netherlands. .
Keith Okamoto O; Human Genome and Stem Cell Research Center, Institute of Biosciences, University of São Paulo, 106, Rua do Matão, Cidade Universitária, São Paulo, 05508-090, Brazil. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 09; Vol. 13 (1), pp. 19481. Date of Electronic Publication: 2023 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Medulloblastoma*/genetics
Cerebellar Neoplasms*/genetics
Child ; Humans ; Cell Proliferation/genetics ; Vesicular Transport Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Subtyping of Group 3/4 medulloblastoma as a potential prognostic biomarker among patients treated with reduced dose of craniospinal irradiation: a Japanese Pediatric Molecular Neuro-Oncology Group study.
Autorzy:
Fukuoka K; Department of Hematology/Oncology, Saitama Children's Medical Center, 1-2, Shin-Toshin, Saitama, 330-8777, Japan. .
Kurihara J; Department of Neurosurgery, Saitama Children's Medical Center, Saitama, Japan.
Shofuda T; Department of Biomedical Research and Innovation, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka, Japan.
Kagawa N; Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Yamasaki K; Department of Pediatric Hematology and Oncology, Osaka City General Hospital, Osaka, Japan.
Ando R; Department of Neurosurgery, Chiba Children's Hospital, Chiba, Japan.
Ishida J; Department of Neurological Surgery, Okayama University Graduate School, Okayama, Japan.
Kanamori M; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kawamura A; Department of Neurosurgery, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
Park YS; Department of Neurosurgery, Nara Medical University, Kashihara, Japan.
Kiyotani C; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Akai T; Departments of Neurosurgery, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan.
Keino D; Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.
Miyairi Y; Department of Neurosurgery, Nagano Children's Hospital, Azumino, Japan.
Sasaki A; Department of Pathology, Saitama Medical University, Saitama, Japan.
Hirato J; Department of Pathology, Public Tomioka General Hospital, Gunma, Japan.
Inoue T; Department of Pathology, Osaka City General Hospital, Osaka, Japan.
Nakazawa A; Department of Clinical Research, Saitama Children's Medical Center, Saitama, Japan.
Koh K; Department of Hematology/Oncology, Saitama Children's Medical Center, 1-2, Shin-Toshin, Saitama, 330-8777, Japan.
Nishikawa R; Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Saitama, Japan.
Date I; Department of Neurological Surgery, Okayama University Graduate School, Okayama, Japan.
Nagane M; Department of Neurosurgery, Kyorin University Faculty of Medicine, Mitaka, Japan.
Ichimura K; Department of Brain Disease Translational Research, Juntendo University Faculty of Medicine, Tokyo, Japan.
Kanemura Y; Department of Biomedical Research and Innovation, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka, Japan.
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Sep 25; Vol. 11 (1), pp. 153. Date of Electronic Publication: 2023 Sep 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cerebellar Neoplasms*/classification
Cerebellar Neoplasms*/pathology
Cerebellar Neoplasms*/radiotherapy
Cerebellar Neoplasms*/surgery
Craniospinal Irradiation*/adverse effects
Medulloblastoma*/classification
Medulloblastoma*/pathology
Medulloblastoma*/radiotherapy
Medulloblastoma*/surgery
Child ; Humans ; East Asian People ; Prognosis ; Biomarkers, Tumor ; DNA Methylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma.
Autorzy:
Pitolli C; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168, Rome, Italy.
Marini A; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168, Rome, Italy.; GSTEP-Organoids Research Core Facility, IRCCS Fondazione Policlinico Universitario Agostino Gemelli, 00168, Rome, Italy.
Guerra M; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168, Rome, Italy.
Pieraccioli M; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168, Rome, Italy.; GSTEP-Organoids Research Core Facility, IRCCS Fondazione Policlinico Universitario Agostino Gemelli, 00168, Rome, Italy.
Marabitti V; Department of Pediatric Hemato-Oncology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Palluzzi F; Bioinformatics Research Core Facility, Gemelli Science and Technology Park (GSTeP), IRCCS Fondazione Policlinico Universitario Agostino Gemelli, 00168, Rome, Italy.; Present Address: Integrated Omics Department, Novo Nordisk, 2860, Søborg, Denmark.
Giacò L; Bioinformatics Research Core Facility, Gemelli Science and Technology Park (GSTeP), IRCCS Fondazione Policlinico Universitario Agostino Gemelli, 00168, Rome, Italy.
Tamburrini G; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168, Rome, Italy.; Pediatric Neurosurgery, IRCCS Fondazione Policlinico Universitario Agostino Gemelli, 00168, Rome, Italy.
Cecconi F; Department of Pediatric Hemato-Oncology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Department of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics Research, Catholic University of the Sacred Heart, 00168, Rome, Italy.; Unit of Cell Stress and Survival, Danish Cancer Society Research Center, Copenhagen, Denmark.
Nazio F; Department of Pediatric Hemato-Oncology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Sette C; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168, Rome, Italy. .; GSTEP-Organoids Research Core Facility, IRCCS Fondazione Policlinico Universitario Agostino Gemelli, 00168, Rome, Italy. .
Pagliarini V; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168, Rome, Italy. .; GSTEP-Organoids Research Core Facility, IRCCS Fondazione Policlinico Universitario Agostino Gemelli, 00168, Rome, Italy. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Aug 21; Vol. 42 (1), pp. 214. Date of Electronic Publication: 2023 Aug 21.
Typ publikacji:
Journal Article
MeSH Terms:
Medulloblastoma*/drug therapy
Medulloblastoma*/genetics
Cerebellar Neoplasms*/drug therapy
Cerebellar Neoplasms*/genetics
Humans ; Up-Regulation ; Anilides ; CDC2 Protein Kinase ; Cyclin-Dependent Kinases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A preliminary study on the mechanism of VASH2 in childhood medulloblastoma.
Autorzy:
Liu W; Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.; The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Fu Y; The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Wang M; Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Zhao J; Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Chen J; Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Wang Y; Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. .; The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. .; Xinjiang Institute of Neurosurgery, Urumqi, China. .
Qin H; Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. .; The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. .; Xinjiang Institute of Neurosurgery, Urumqi, China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 11; Vol. 13 (1), pp. 17153. Date of Electronic Publication: 2023 Oct 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Medulloblastoma*/pathology
Cerebellar Neoplasms*/pathology
Humans ; Male ; Child ; Matrix Metalloproteinase 2 ; Cell Line, Tumor ; Cell Proliferation/genetics ; Vasopressins/therapeutic use ; Angiogenic Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Low Expression of the NRP1 Gene Is Associated with Shorter Overall Survival in Patients with Sonic Hedgehog and Group 3 Medulloblastoma.
Autorzy:
de Araújo MA; Graduate Program in Principles of Surgery, Mackenzie Evangelical University, Curitiba 80730-000, PR, Brazil.; The Center for Advanced Neurology and Neurosurgery (CEANNE), Porto Alegre 90560-010, RS, Brazil.
Malafaia O; Graduate Program in Principles of Surgery, Mackenzie Evangelical University, Curitiba 80730-000, PR, Brazil.
Ribas Filho JM; Graduate Program in Principles of Surgery, Mackenzie Evangelical University, Curitiba 80730-000, PR, Brazil.
Fratini L; Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre 90035-003, RS, Brazil.; Research Center, Moinhos de Vento Hospital, Porto Alegre 90035-001, RS, Brazil.
Roesler R; Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre 90035-003, RS, Brazil.
Isolan GR; Graduate Program in Principles of Surgery, Mackenzie Evangelical University, Curitiba 80730-000, PR, Brazil.; The Center for Advanced Neurology and Neurosurgery (CEANNE), Porto Alegre 90560-010, RS, Brazil.; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre 90035-003, RS, Brazil.; Spalt Therapeutics, Porto Alegre 90560-010, RS, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 18; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 18.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Neoplasms*/genetics
Brain Neoplasms*/metabolism
Cerebellar Neoplasms*/metabolism
Medulloblastoma*/genetics
Medulloblastoma*/metabolism
Child ; Humans ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MRI features of pediatric atypical teratoid rhabdoid tumors and medulloblastomas of the posterior fossa.
Autorzy:
Wu HW; Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Wu CH; Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Lin SC; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Wu CC; Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chen HH; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Pediatric Neurosurgery, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Chen YW; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Medical Imaging and Radiological Technology, Yuanpei University of Medical Technology, Hsinchu City, Taiwan.
Lee YY; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Pediatric Neurosurgery, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Chang FC; Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
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Źródło:
Cancer medicine [Cancer Med] 2023 May; Vol. 12 (9), pp. 10449-10461. Date of Electronic Publication: 2023 Mar 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Medulloblastoma*/diagnostic imaging
Medulloblastoma*/pathology
Rhabdoid Tumor*/diagnostic imaging
Rhabdoid Tumor*/pathology
Cerebellar Neoplasms*/diagnostic imaging
Cerebellar Neoplasms*/pathology
Central Nervous System Neoplasms*
Teratoma*/diagnostic imaging
Teratoma*/pathology
Child ; Humans ; Retrospective Studies ; Magnetic Resonance Imaging
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mitochondrial DNA mutations in Medulloblastoma.
Autorzy:
Funke VLE; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Sandmann S; Institute of Medical Informatics, University of Münster, 48149, Münster, Germany.
Melcher V; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Seggewiss J; Institute of Human Genetics, University Hospital Münster, Münster, Germany.
Horvath J; Institute of Human Genetics, University Hospital Münster, Münster, Germany.
Jäger N; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
Kool M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Milde T; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
Rutkowski S; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany.
Mynarek M; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Varghese J; Institute of Medical Informatics, University of Münster, 48149, Münster, Germany.
Sträter R; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Rust S; Department of General Pediatrics, Metabolic Diseases, University Children's Hospital Münster, 48149, Münster, Germany.
Seelhöfer A; Department of General Pediatrics, Metabolic Diseases, University Children's Hospital Münster, 48149, Münster, Germany.
Reunert J; Department of General Pediatrics, Metabolic Diseases, University Children's Hospital Münster, 48149, Münster, Germany.
Fiedler B; Department of Neuropediatrics, University Children's Hospital, Münster, Germany.
Schüller U; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany.; Research Institute Children's Cancer Center, 20251, Hamburg, Germany.; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany.
Marquardt T; Department of General Pediatrics, Metabolic Diseases, University Children's Hospital Münster, 48149, Münster, Germany.
Kerl K; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Jul 27; Vol. 11 (1), pp. 124. Date of Electronic Publication: 2023 Jul 27.
Typ publikacji:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Medulloblastoma*/genetics
Mitochondrial Diseases*
Cerebellar Neoplasms*/genetics
Humans ; Female ; Mutation/genetics ; DNA, Mitochondrial/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dynamic profiling of medulloblastoma surfaceome.
Autorzy:
Bakhshinyan D; McMaster Centre for Discovery in Cancer Research, McMaster University, MDCL 5027, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Suk Y; McMaster Centre for Discovery in Cancer Research, McMaster University, MDCL 5027, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.; Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Kuhlmann L; Princess Margaret Cancer Center, UHN, Toronto, ON, Canada.
Adile AA; McMaster Centre for Discovery in Cancer Research, McMaster University, MDCL 5027, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Ignatchenko V; Princess Margaret Cancer Center, UHN, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Custers S; McMaster Centre for Discovery in Cancer Research, McMaster University, MDCL 5027, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Gwynne WD; McMaster Centre for Discovery in Cancer Research, McMaster University, MDCL 5027, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Macklin A; Princess Margaret Cancer Center, UHN, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Venugopal C; McMaster Centre for Discovery in Cancer Research, McMaster University, MDCL 5027, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Kislinger T; Princess Margaret Cancer Center, UHN, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Singh SK; McMaster Centre for Discovery in Cancer Research, McMaster University, MDCL 5027, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. .; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada. .; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Jul 10; Vol. 11 (1), pp. 111. Date of Electronic Publication: 2023 Jul 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Medulloblastoma*/therapy
Brain Neoplasms*
Cerebellar Neoplasms*/therapy
Humans ; Child ; Brain ; Aggression
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Group-specific cellular metabolism in Medulloblastoma.
Autorzy:
Funke VLE; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Walter C; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.; Institute of Medical Informatics, University of Münster, 48149, Münster, Germany.
Melcher V; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Wei L; Institute of Medical Informatics, University of Münster, 48149, Münster, Germany.
Sandmann S; Institute of Medical Informatics, University of Münster, 48149, Münster, Germany.
Hotfilder M; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Varghese J; Institute of Medical Informatics, University of Münster, 48149, Münster, Germany.
Jäger N; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Kool M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
Milde T; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
Mynarek M; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rutkowski S; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany.
Seggewiss J; Institute of Human Genetics, University Hospital Münster, Münster, Germany.
Jeising D; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
de Faria FW; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Marquardt T; Department of General Pediatrics, Metabolic Diseases, University Children's Hospital Münster, 48149, Münster, Germany.
Albert TK; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Schüller U; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany.; Research Institute Children's Cancer Center, 20251, Hamburg, Germany.; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany.
Kerl K; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Jun 05; Vol. 21 (1), pp. 363. Date of Electronic Publication: 2023 Jun 05.
Typ publikacji:
Journal Article
MeSH Terms:
Medulloblastoma*/genetics
Cerebellar Neoplasms*/genetics
Humans ; Mutation ; Phenotype ; RNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In Vivo Radiobiological Investigations with the TOP-IMPLART Proton Beam on a Medulloblastoma Mouse Model.
Autorzy:
Giovannini D; ENEA SSPT-TECS-TEB, Casaccia Research Center, Division of Health Protection Technology (TECS), Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Via Anguillarese 301, 00123 Rome, Italy.
De Angelis C; Istituto Superiore di Sanità (ISS), Viale Regina Elena 299, 00161 Rome, Italy.
Astorino MD; ENEA FSN-TECFIS-APAM, Frascati Research Center, Via Enrico Fermi 45, 00044 Frascati, Italy.
Fratini E; ENEA SSPT-TECS-TEB, Casaccia Research Center, Division of Health Protection Technology (TECS), Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Via Anguillarese 301, 00123 Rome, Italy.
Cisbani E; Istituto Superiore di Sanità (ISS), Viale Regina Elena 299, 00161 Rome, Italy.
Bazzano G; ENEA FSN-TECFIS-APAM, Frascati Research Center, Via Enrico Fermi 45, 00044 Frascati, Italy.
Ampollini A; ENEA FSN-TECFIS-APAM, Frascati Research Center, Via Enrico Fermi 45, 00044 Frascati, Italy.
Piccinini M; ENEA FSN-TECFIS-MNF, Frascati Research Center, Via Enrico Fermi 45, 00044 Frascati, Italy.
Nichelatti E; ENEA FSN-TECFIS-MNF, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.
Trinca E; ENEA FSN-TECFIS-APAM, Frascati Research Center, Via Enrico Fermi 45, 00044 Frascati, Italy.
Nenzi P; ENEA FSN-TECFIS-APAM, Frascati Research Center, Via Enrico Fermi 45, 00044 Frascati, Italy.
Mancuso M; ENEA SSPT-TECS-TEB, Casaccia Research Center, Division of Health Protection Technology (TECS), Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Via Anguillarese 301, 00123 Rome, Italy.
Picardi L; ENEA FSN-TECFIS-APAM, Frascati Research Center, Via Enrico Fermi 45, 00044 Frascati, Italy.
Marino C; ENEA SSPT-TECS-TEB, Casaccia Research Center, Division of Health Protection Technology (TECS), Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Via Anguillarese 301, 00123 Rome, Italy.
Ronsivalle C; ENEA FSN-TECFIS-APAM, Frascati Research Center, Via Enrico Fermi 45, 00044 Frascati, Italy.
Pazzaglia S; ENEA SSPT-TECS-TEB, Casaccia Research Center, Division of Health Protection Technology (TECS), Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Via Anguillarese 301, 00123 Rome, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 05; Vol. 24 (9). Date of Electronic Publication: 2023 May 05.
Typ publikacji:
Journal Article
MeSH Terms:
Medulloblastoma*/radiotherapy
Cerebellar Neoplasms*/radiotherapy
Mice ; Animals ; Protons ; Caspase 3 ; Radiobiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition.
Autorzy:
Vo T; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Balderson B; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Jones K; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Ni G; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Crawford J; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Millar A; The University of Queensland Frazer Institute, Translational Research Institute, Woolloongabba, QLD, 4102, Australia.
Tolson E; The University of Queensland Frazer Institute, Translational Research Institute, Woolloongabba, QLD, 4102, Australia.
Singleton M; The University of Queensland Frazer Institute, Translational Research Institute, Woolloongabba, QLD, 4102, Australia.
Kojic M; The University of Queensland Frazer Institute, Translational Research Institute, Woolloongabba, QLD, 4102, Australia.
Robertson T; Department of Pathology, Royal Brisbane and Women's Hospital, University of Queensland, Brisbane, QLD, 4029, Australia.
Walters S; School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, 4072, Australia.
Mulay O; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Bhuva DD; Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC, 3010, Australia.; Faculty of Medicine, South Australian Immunogenomics Cancer Institute, The University of Adelaide, Adelaide, SA, 5000, Australia.
Davis MJ; The University of Queensland Frazer Institute, Translational Research Institute, Woolloongabba, QLD, 4102, Australia.; Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC, 3010, Australia.; Faculty of Medicine, South Australian Immunogenomics Cancer Institute, The University of Adelaide, Adelaide, SA, 5000, Australia.; Department of Clinical Pathology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC, 3010, Australia.
Wainwright BJ; The University of Queensland Frazer Institute, Translational Research Institute, Woolloongabba, QLD, 4102, Australia.
Nguyen Q; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia. .
Genovesi LA; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia. .; The University of Queensland Frazer Institute, Translational Research Institute, Woolloongabba, QLD, 4102, Australia. .
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Źródło:
Genome medicine [Genome Med] 2023 May 01; Vol. 15 (1), pp. 29. Date of Electronic Publication: 2023 May 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cerebellar Neoplasms*/metabolism
Medulloblastoma*/metabolism
Animals ; Humans ; Mice ; Cell Differentiation ; Cyclin-Dependent Kinase 4/genetics ; Cyclin-Dependent Kinase 4/metabolism ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Transcriptome ; Cyclin-Dependent Kinase 6/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Global metabolomics study on the pathogenesis of pediatric medulloblastoma via UPLC- Q/E-MS/MS.
Autorzy:
Huang Z; Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Li X; Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Wei B; Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Yu Y; Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
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Źródło:
PloS one [PLoS One] 2023 Jun 15; Vol. 18 (6), pp. e0287121. Date of Electronic Publication: 2023 Jun 15 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Medulloblastoma*/diagnosis
Cerebellar Neoplasms*/diagnosis
Humans ; Child ; Tandem Mass Spectrometry ; Metabolomics/methods ; Metabolome ; Biomarkers ; Chromatography, High Pressure Liquid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
YB1 modulates the DNA damage response in medulloblastoma.
Autorzy:
McSwain LF; Department of Pediatrics, Emory University, 1760 Haygood Dr., Atlanta, GA, 30322, USA.
Pillsbury CE; Department of Pediatrics, Emory University, 1760 Haygood Dr., Atlanta, GA, 30322, USA.
Haji-Seyed-Javadi R; Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Rath SK; Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Chen V; Department of Biology, Emory University, Atlanta, GA, 30322, USA.
Huang T; Department of Biology, Emory University, Atlanta, GA, 30322, USA.
Shahab SW; Department of Pediatrics, Emory University, 1760 Haygood Dr., Atlanta, GA, 30322, USA.
Kunhiraman H; Department of Pediatrics, Emory University, 1760 Haygood Dr., Atlanta, GA, 30322, USA.
Ross J; Department of Microbiology and Immunology, Emory Vaccine Center, Emory University, Atlanta, GA, USA.
Price GA; Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Dey A; Department of Pediatrics, Emory University, 1760 Haygood Dr., Atlanta, GA, 30322, USA.
Hambardzumyan D; Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
MacDonald T; Department of Pediatrics, Emory University, 1760 Haygood Dr., Atlanta, GA, 30322, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Yu DS; Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Porter CC; Department of Pediatrics, Emory University, 1760 Haygood Dr., Atlanta, GA, 30322, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Kenney AM; Department of Pediatrics, Emory University, 1760 Haygood Dr., Atlanta, GA, 30322, USA. .; Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 May 19; Vol. 13 (1), pp. 8087. Date of Electronic Publication: 2023 May 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Neoplasms*/metabolism
Cerebellar Neoplasms*/pathology
Medulloblastoma*/pathology
Neural Stem Cells*/metabolism
Y-Box-Binding Protein 1*/metabolism
Animals ; Humans ; Mice ; Cell Proliferation ; DNA Damage ; Hedgehog Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 11631

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