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Podgląd okładki
Tytuł :
Establishment of a megakaryoblastic cell line for conventional assessment of platelet calcium signaling.
Autorzy :
Saito H; Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, 329-0498, Japan.
Hayakawa M; Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, 329-0498, Japan.
Kamoshita N; Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, 329-0498, Japan.
Yasumoto A; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Suzuki-Inoue K; Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, 409-3898, Japan.
Yatomi Y; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Ohmori T; Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, 329-0498, Japan. .
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Źródło :
International journal of hematology [Int J Hematol] 2020 Jun; Vol. 111 (6), pp. 786-794. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium Signaling*
Megakaryocyte Progenitor Cells*/metabolism
Platelet Activation*
Blood Platelets/*metabolism
Blood Platelets/*physiology
Calcium/*metabolism
Cell Line ; Drug Discovery ; Drug Evaluation, Preclinical ; Green Fluorescent Proteins/metabolism ; Humans ; Phosphatidylinositols/metabolism ; Platelet Aggregation Inhibitors ; Receptors, IgG/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Imetelstat inhibits growth of megakaryocyte colony-forming units from patients with essential thrombocythemia.
Autorzy :
Baerlocher GM; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, and.; Laboratory for Hematopoiesis and Molecular Genetics, Department of BioMedical Research, University of Bern, Bern, Switzerland.
Haubitz M; Laboratory for Hematopoiesis and Molecular Genetics, Department of BioMedical Research, University of Bern, Bern, Switzerland.
Braschler TR; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, and.; Department of Hematology, Luzerner Kantonsspital, Lucerne, Switzerland; and.
Brunold C; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, and.
Burington B; Geron Corporation, Menlo Park, CA.
Oppliger Leibundgut E; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, and.; Laboratory for Hematopoiesis and Molecular Genetics, Department of BioMedical Research, University of Bern, Bern, Switzerland.
Go N; Geron Corporation, Menlo Park, CA.
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Źródło :
Blood advances [Blood Adv] 2019 Nov 26; Vol. 3 (22), pp. 3724-3728.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation/*drug effects
Enzyme Inhibitors/*pharmacology
Megakaryocyte Progenitor Cells/*drug effects
Megakaryocyte Progenitor Cells/*metabolism
Oligonucleotides/*pharmacology
Thrombocythemia, Essential/*metabolism
Aged ; Aged, 80 and over ; Alleles ; Amino Acid Substitution ; Biomarkers ; Female ; Humans ; Janus Kinase 2/genetics ; Male ; Megakaryocyte Progenitor Cells/cytology ; Megakaryocytes/cytology ; Megakaryocytes/drug effects ; Megakaryocytes/metabolism ; Middle Aged ; Mutation ; Thrombocythemia, Essential/drug therapy ; Thrombocythemia, Essential/etiology
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors.
Autorzy :
Zhu F; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305; .; Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Feng M; Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010.
Sinha R; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.; Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Murphy MP; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.; Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine, Stanford, CA 94305.; Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine, Stanford, CA 94305.
Luo F; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
Kao KS; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.; Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Szade K; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.; Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Seita J; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.; Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Weissman IL; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305; .; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Sep 10; Vol. 116 (37), pp. 18416-18422. Date of Electronic Publication: 2019 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cells/*metabolism
Megakaryocyte Progenitor Cells/*metabolism
Receptors, GABA-A/*metabolism
Animals ; Blood Platelets/cytology ; Blood Platelets/metabolism ; Cell Differentiation/physiology ; Hematopoiesis ; Hematopoietic Stem Cells/cytology ; Humans ; Male ; Megakaryocyte Progenitor Cells/cytology ; Megakaryocytes/cytology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Animal ; Receptors, GABA ; Receptors, GABA-A/genetics ; Transcriptome
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
CD45 expression discriminates waves of embryonic megakaryocytes in the mouse.
Autorzy :
Cortegano I; Department of Immunology, Centro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda .
Serrano N; Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CBMSO-CSIC), Madrid.
Ruiz C; Department of Immunology, Centro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda.
Rodríguez M; Department of Immunology, Centro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda.
Prado C; Department of Immunology, Centro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda.
Alía M; Department of Immunology, Centro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda.
Hidalgo A; Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares, Madrid.
Cano E; Neuroinflamation Unit, Chronic Diseases Research Program, Instituto de Salud Carlos III (ISCIII), Majadahonda, Spain.
de Andrés B; Department of Immunology, Centro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda.
Gaspar ML; Department of Immunology, Centro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda .
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Źródło :
Haematologica [Haematologica] 2019 Sep; Vol. 104 (9), pp. 1853-1865. Date of Electronic Publication: 2018 Dec 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Lineage/*genetics
Embryo, Mammalian/*metabolism
Leukocyte Common Antigens/*genetics
Megakaryocyte Progenitor Cells/*metabolism
Megakaryocytes/*metabolism
Animals ; Antigens, CD/classification ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Biomarkers/metabolism ; Cell Differentiation ; Embryo, Mammalian/cytology ; Flow Cytometry ; Gene Expression ; Hematopoiesis/genetics ; Immunophenotyping/methods ; Leukocyte Common Antigens/metabolism ; Liver/cytology ; Liver/metabolism ; Megakaryocyte Progenitor Cells/classification ; Megakaryocyte Progenitor Cells/cytology ; Megakaryocytes/classification ; Megakaryocytes/cytology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Primary Cell Culture ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/genetics ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Tetraploidy
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice.
Autorzy :
Xavier-Ferrucio J; Department of Laboratory Medicine.; Yale Stem Cell Center.
Scanlon V; Department of Laboratory Medicine.; Yale Stem Cell Center.
Li X; Department of Pathology.
Zhang PX; Department of Laboratory Medicine.; Yale Stem Cell Center.
Lozovatsky L; Department of Pathology.
Ayala-Lopez N; Department of Laboratory Medicine.; Yale Stem Cell Center.
Tebaldi T; Section of Hematology, Department of Internal Medicine.; Yale Comprehensive Cancer Center, and.; Yale Center for RNA Science and Medicine, Yale School of Medicine, New Haven, CT; and.
Halene S; Yale Stem Cell Center.; Section of Hematology, Department of Internal Medicine.; Yale Comprehensive Cancer Center, and.; Yale Center for RNA Science and Medicine, Yale School of Medicine, New Haven, CT; and.
Cao C; Department of Pathology, Boston Children's Hospital, Boston, MA.
Fleming MD; Department of Pathology, Boston Children's Hospital, Boston, MA.
Finberg KE; Department of Pathology.
Krause DS; Department of Laboratory Medicine.; Yale Stem Cell Center.; Department of Pathology.
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Źródło :
Blood [Blood] 2019 Oct 31; Vol. 134 (18), pp. 1547-1557.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anemia, Iron-Deficiency/*metabolism
Cell Differentiation/*physiology
Megakaryocyte Progenitor Cells/*metabolism
Megakaryocytes/*metabolism
Anemia, Iron-Deficiency/complications ; Animals ; Cell Proliferation ; Humans ; Iron ; Megakaryocyte Progenitor Cells/cytology ; Megakaryocytes/cytology ; Mice ; Mice, Knockout ; Thrombocytosis/etiology ; Thrombocytosis/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia-initiating cells.
Autorzy :
Hu T; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Morita K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Hill MC; Program in Developmental Biology, Baylor College of Medicine, Houston, TX.
Jiang Y; Program in Developmental Biology, Baylor College of Medicine, Houston, TX.
Kitano A; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Saito Y; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.; Division of Tumor and Cellular Biochemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Wang F; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Mao X; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
Hoegenauer KA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Morishita K; Division of Tumor and Cellular Biochemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Martin JF; Program in Developmental Biology, Baylor College of Medicine, Houston, TX.; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX; and.; Texas Heart Institute, Baylor St Luke's Medical Center, Houston, TX.
Futreal PA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
Takahashi K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
Nakada D; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.; Program in Developmental Biology, Baylor College of Medicine, Houston, TX.
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Źródło :
Blood [Blood] 2019 Aug 15; Vol. 134 (7), pp. 614-625. Date of Electronic Publication: 2019 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Transformation, Neoplastic/*pathology
DNA-Binding Proteins/*genetics
Leukemia, Myeloid, Acute/*pathology
Megakaryocyte-Erythroid Progenitor Cells/*pathology
Transcription Factors/*genetics
Animals ; Cell Transformation, Neoplastic/genetics ; Gene Expression Regulation, Leukemic ; Gene Regulatory Networks ; Humans ; Leukemia, Myeloid, Acute/genetics ; Megakaryocyte-Erythroid Progenitor Cells/metabolism ; Mice, Inbred C57BL ; Proto-Oncogene Proteins/genetics ; Trans-Activators/genetics ; Translocation, Genetic
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Enabling Large-Scale Ex Vivo Production of Megakaryocytes from CD34 Cells Using Gas-Permeable Surfaces.
Autorzy :
Martinez AF; Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA.
Miller WM; Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois, USA.
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Źródło :
Stem cells translational medicine [Stem Cells Transl Med] 2019 Jul; Vol. 8 (7), pp. 658-670. Date of Electronic Publication: 2019 Mar 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Culture Techniques*
Cell Proliferation*
Blood Platelets/*metabolism
Megakaryocyte Progenitor Cells/*metabolism
Megakaryocytes/*metabolism
Antigens, CD34/metabolism ; Blood Platelets/cytology ; Humans ; Megakaryocyte Progenitor Cells/cytology ; Megakaryocytes/cytology
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
The Gata1 murine megakaryocyte-erythroid progenitor cells expand robustly and alter differentiation potential.
Autorzy :
Shin E; Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology Yuseong-gu, Daejeon, 34141, South Korea; College of Pharmacy, Chungnam National University, Yuseong-gu, Daejeon, 34134, South Korea.
Jeong JG; Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology Yuseong-gu, Daejeon, 34141, South Korea.
Chung H; Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology Yuseong-gu, Daejeon, 34141, South Korea.
Jung H; Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology Yuseong-gu, Daejeon, 34141, South Korea.
Park C; Bioinformatics Team, Research Institute, National Cancer Center, Ilsandong-gu, Gyeonggi-do, 10408, South Korea.
Yoon SR; Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology Yuseong-gu, Daejeon, 34141, South Korea.
Kim TD; Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology Yuseong-gu, Daejeon, 34141, South Korea.
Lee SJ; College of Pharmacy, Chungnam National University, Yuseong-gu, Daejeon, 34134, South Korea.
Choi I; Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology Yuseong-gu, Daejeon, 34141, South Korea. Electronic address: .
Noh JY; Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology Yuseong-gu, Daejeon, 34141, South Korea. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jul 12; Vol. 528 (1), pp. 46-53. Date of Electronic Publication: 2020 May 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
GATA1 Transcription Factor/*metabolism
Megakaryocyte-Erythroid Progenitor Cells/*cytology
Megakaryocyte-Erythroid Progenitor Cells/*metabolism
Animals ; Cell Cycle ; Cell Proliferation ; Cells, Cultured ; Mice ; Platelet Membrane Glycoprotein IIb/metabolism ; Signal Transduction
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Stem cell factor and NSC87877 combine to enhance c-Kit mediated proliferation of human megakaryoblastic cells.
Autorzy :
Raghav PK; Division of Stem Cell and Gene Therapy Research, Institute of Nuclear Medicine and Allied Sciences (INMAS), Timarpur, Delhi, India.
Singh AK; Division of Stem Cell and Gene Therapy Research, Institute of Nuclear Medicine and Allied Sciences (INMAS), Timarpur, Delhi, India.
Gangenahalli G; Division of Stem Cell and Gene Therapy Research, Institute of Nuclear Medicine and Allied Sciences (INMAS), Timarpur, Delhi, India.
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Źródło :
PloS one [PLoS One] 2018 Nov 02; Vol. 13 (11), pp. e0206364. Date of Electronic Publication: 2018 Nov 02 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Megakaryocyte Progenitor Cells/*cytology
Megakaryocyte Progenitor Cells/*drug effects
Proto-Oncogene Proteins c-kit/*metabolism
Quinolines/*pharmacology
Stem Cell Factor/*pharmacology
Cell Proliferation/drug effects ; Drug Interactions ; Gene Expression Regulation/drug effects ; Humans ; Megakaryocyte Progenitor Cells/metabolism ; Phosphorylation/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
Overexpression of Short Variant Form of New Kelch Family Protein Leads to Erythroid and Megakaryocyte Dysplasia by Targeting Megakaryocyte-Erythroid Progenitors.
Autorzy :
Lin Y; 1 Department of Hematology, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, China .; 2 Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University , Guangzhou, China .
Luo Y; 1 Department of Hematology, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, China .
Hu F; 2 Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University , Guangzhou, China .
Wang T; 2 Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University , Guangzhou, China .
Dong Y; 2 Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University , Guangzhou, China .
Yang D; 2 Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University , Guangzhou, China .
He X; 2 Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University , Guangzhou, China .
Chen X; 2 Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University , Guangzhou, China .
Wang J; 2 Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University , Guangzhou, China .
Du J; 2 Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University , Guangzhou, China .
Zhang X; 1 Department of Hematology, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, China .
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Źródło :
DNA and cell biology [DNA Cell Biol] 2018 Oct; Vol. 37 (10), pp. 831-838. Date of Electronic Publication: 2018 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Hematopoiesis/*genetics
Hematopoietic Stem Cells/*metabolism
Megakaryocyte-Erythroid Progenitor Cells/*metabolism
Megakaryocytes/*metabolism
Myelodysplastic Syndromes/*genetics
Proteins/*genetics
Animals ; Cell Differentiation ; Female ; Gene Expression ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/pathology ; Intracellular Signaling Peptides and Proteins ; Megakaryocyte-Erythroid Progenitor Cells/pathology ; Megakaryocytes/pathology ; Mice ; Mice, Inbred C57BL ; Myelodysplastic Syndromes/metabolism ; Myelodysplastic Syndromes/pathology ; Proteins/metabolism ; Transgenes ; Whole-Body Irradiation
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Myeloid sarcoma with megakaryoblastic differentiation presenting as a breast mass.
Autorzy :
Obiorah IE; Department of Pathology, Medstar Georgetown University Hospital, Washington, D.C. 20007, United States. Electronic address: .
Ozdemirli M; Department of Pathology, Medstar Georgetown University Hospital, Washington, D.C. 20007, United States.
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Źródło :
Hematology/oncology and stem cell therapy [Hematol Oncol Stem Cell Ther] 2018 Sep; Vol. 11 (3), pp. 178-182. Date of Electronic Publication: 2018 Apr 17.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Breast Neoplasms*/metabolism
Breast Neoplasms*/pathology
Cell Differentiation*
Megakaryocyte Progenitor Cells*/metabolism
Megakaryocyte Progenitor Cells*/pathology
Sarcoma, Myeloid*/metabolism
Sarcoma, Myeloid*/pathology
Antigens, Differentiation/*metabolism
Neoplasm Proteins/*metabolism
Female ; Humans ; Middle Aged
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Cytokine control of megakaryopoiesis.
Autorzy :
Behrens K; a The Walter and Eliza Hall Institute of Medical Research , Parkville , Australia.; b Department of Medical Biology , University of Melbourne , Melbourne , Australia.
Alexander WS; a The Walter and Eliza Hall Institute of Medical Research , Parkville , Australia.; b Department of Medical Biology , University of Melbourne , Melbourne , Australia.
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Źródło :
Growth factors (Chur, Switzerland) [Growth Factors] 2018 Aug; Vol. 36 (3-4), pp. 89-103. Date of Electronic Publication: 2018 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Hematopoiesis*
Cytokines/*metabolism
Megakaryocyte Progenitor Cells/*cytology
Animals ; Blood Platelets/cytology ; Blood Platelets/metabolism ; Cytokines/genetics ; Humans ; Megakaryocyte Progenitor Cells/metabolism ; Megakaryocytes/cytology ; Megakaryocytes/metabolism
Czasopismo naukowe
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
Zika virus infection studies with CD34 hematopoietic and megakaryocyte-erythroid progenitors, red blood cells and platelets.
Autorzy :
Roth H; Division of Virology, Paul-Ehrlich-Institute, Langen, Hessen, Germany.
Schneider L; Institute for Transfusion Medicine and Immunohematology, Goethe-University and German Red Cross Blood Service, Frankfurt am Main, Hessen, Germany.
Eberle R; Division of Immunology, Paul-Ehrlich-Institute, Langen, Hessen, Germany.
Lausen J; Institute for Transfusion Medicine and Immunohematology, Goethe-University and German Red Cross Blood Service, Frankfurt am Main, Hessen, Germany.; Department of Genetics of Eukaryotes, Institute of Industrial Genetics, Stuttgart, Baden-Württemberg, Germany.
Modlich U; Division of Veterinary Medicine, Paul-Ehrlich-Institute, Langen, Hessen, Germany.
Blümel J; Division of Virology, Paul-Ehrlich-Institute, Langen, Hessen, Germany.
Baylis SA; Division of Virology, Paul-Ehrlich-Institute, Langen, Hessen, Germany.
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Źródło :
Transfusion [Transfusion] 2020 Mar; Vol. 60 (3), pp. 561-574. Date of Electronic Publication: 2020 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD34/*metabolism
Blood Platelets/*metabolism
Hematopoietic Stem Cells/*metabolism
Megakaryocyte-Erythroid Progenitor Cells/*metabolism
Zika Virus/*pathogenicity
Zika Virus Infection/*metabolism
Cell Differentiation/physiology ; Cell Line ; Erythrocytes/cytology ; Humans ; RNA, Viral/genetics
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Regulation of bone metabolism by megakaryocytes in a paracrine manner.
Autorzy :
Lee YS; Asan Institute for Life Sciences, 88 Olympic-Ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
Kwak MK; Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43 gil, Songpa-gu, Seoul, 05505, Korea.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, 7, Keunjaebong-gil, Hwaseong-Si, Gyeonggi-Do, 445-907, Korea.
Moon SA; Asan Institute for Life Sciences, 88 Olympic-Ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
Choi YJ; Asan Institute for Life Sciences, 88 Olympic-Ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
Baek JE; Asan Institute for Life Sciences, 88 Olympic-Ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
Park SY; Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
Kim BJ; Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
Lee SH; Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
Koh JM; Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43 gil, Songpa-gu, Seoul, 05505, Korea. .
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Źródło :
Scientific reports [Sci Rep] 2020 Feb 10; Vol. 10 (1), pp. 2277. Date of Electronic Publication: 2020 Feb 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Paracrine Communication*
Cell Differentiation/*drug effects
Culture Media, Conditioned/*pharmacology
Megakaryocytes/*metabolism
Osteogenesis/*drug effects
Animals ; Bone Resorption/diagnostic imaging ; Bone Resorption/drug therapy ; Bone Resorption/etiology ; Cell Differentiation/physiology ; Culture Media, Conditioned/metabolism ; Disease Models, Animal ; Female ; Femur/diagnostic imaging ; Femur/physiology ; Humans ; Injections, Intravenous ; K562 Cells ; Macrophages/drug effects ; Macrophages/physiology ; Megakaryocyte Progenitor Cells/metabolism ; Mice ; Osteoclasts/physiology ; Osteoporosis, Postmenopausal/diagnostic imaging ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporosis, Postmenopausal/etiology ; Ovariectomy ; Skull/drug effects ; Skull/physiology ; X-Ray Microtomography
Czasopismo naukowe
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
Prolonged inhibition and incomplete recovery of mitochondrial function in oxazolidinone-treated megakaryoblastic cell lines.
Autorzy :
Milosevic TV; Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Vertenoeil G; Signal Transduction and Molecular Haematology, Ludwig Institute for Cancer Research, Brussels Branch, Brussels, Belgium; de Duve Institute, Université catholique de Louvain, Brussels, Belgium.
Payen VL; Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.
Sonveaux P; Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.
Tulkens PM; Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium. Electronic address: .
Constantinescu SN; Signal Transduction and Molecular Haematology, Ludwig Institute for Cancer Research, Brussels Branch, Brussels, Belgium; de Duve Institute, Université catholique de Louvain, Brussels, Belgium; Walloon Excellence in Life Science and Biotechnology, Brussels, Belgium.
Van Bambeke F; Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Nov; Vol. 54 (5), pp. 661-667. Date of Electronic Publication: 2019 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Electron Transport Complex IV/*antagonists & inhibitors
Linezolid/*toxicity
Megakaryocyte Progenitor Cells/*metabolism
Mitochondria/*drug effects
Oxazolidinones/*toxicity
Protein Synthesis Inhibitors/*toxicity
Tetrazoles/*toxicity
Cell Line ; Electron Transport Complex IV/metabolism ; Humans ; Mitochondria/metabolism ; Oxygen Consumption/drug effects ; Thrombocytopenia/chemically induced
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression.
Autorzy :
Hansen M; Department Hematopoiesis, Sanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centre, 1066CX Amsterdam, The Netherlands.
Zeddies S; Department Hematopoiesis, Sanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centre, 1066CX Amsterdam, The Netherlands.
Meinders M; Department Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam,1066CX Amsterdam, The Netherlands.
di Summa F; Department Hematopoiesis, Sanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centre, 1066CX Amsterdam, The Netherlands.
van Alphen FPJ; Department of Molecular and Cellular Hemostasis, Sanquin Research, 1066CX Amsterdam, The Netherlands.
Hoogendijk AJ; Department of Molecular and Cellular Hemostasis, Sanquin Research, 1066CX Amsterdam, The Netherlands.
Moore KS; Department Hematopoiesis, Sanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centre, 1066CX Amsterdam, The Netherlands.
Halbach M; Experimental Neurology, Goethe University Medical School, 60528 Frankfurt am Main, Germany.
Gutiérrez L; Department Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam,1066CX Amsterdam, The Netherlands.
van den Biggelaar M; Department of Molecular and Cellular Hemostasis, Sanquin Research, 1066CX Amsterdam, The Netherlands.
Thijssen-Timmer DC; Department Hematopoiesis, Sanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centre, 1066CX Amsterdam, The Netherlands.
Auburger GWJ; Experimental Neurology, Goethe University Medical School, 60528 Frankfurt am Main, Germany.
van den Akker E; Department Hematopoiesis, Sanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centre, 1066CX Amsterdam, The Netherlands.
von Lindern M; Department Hematopoiesis, Sanquin Research, and Landsteiner Laboratory, Amsterdam University Medical Centre, 1066CX Amsterdam, The Netherlands.
Rollmann E; Experimental Neurology, Goethe University Medical School, 60528 Frankfurt am Main, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 31; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 31.
Typ publikacji :
Journal Article
MeSH Terms :
Ataxin-2/*genetics
Gene Expression Profiling/*methods
Megakaryocyte Progenitor Cells/*cytology
Animals ; Antigens, CD34/genetics ; Ataxin-2/metabolism ; Cell Differentiation ; Cell Line ; DEAD-box RNA Helicases/genetics ; Gene Expression Regulation ; Humans ; Mice ; Platelet Membrane Glycoprotein IIb/genetics ; Proto-Oncogene Proteins/genetics
Czasopismo naukowe
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
Unexpected lymph node finding in a patient with essential thrombocythemia.
Autorzy :
Hale DA; Baylor University Medical Center.
Krause JR; Baylor University Medical Center.
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Źródło :
Blood [Blood] 2020 Jan 09; Vol. 135 (2), pp. 154.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Cell Differentiation*
Lymph Nodes/*pathology
Megakaryocyte Progenitor Cells/*pathology
Sarcoma, Myeloid/*pathology
Thrombocythemia, Essential/*complications
Aged ; Humans ; Male ; Prognosis ; Sarcoma, Myeloid/etiology
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Identification of unipotent megakaryocyte progenitors in human hematopoiesis.
Autorzy :
Miyawaki K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Iwasaki H; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.
Jiromaru T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Kusumoto H; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Yurino A; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Sugio T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Uehara Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Odawara J; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Daitoku S; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Kunisaki Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Mori Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Arinobu Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Tsuzuki H; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Kikushige Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Iino T; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.
Kato K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Takenaka K; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.
Miyamoto T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.
Maeda T; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.
Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; and.; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.
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Źródło :
Blood [Blood] 2017 Jun 22; Vol. 129 (25), pp. 3332-3343. Date of Electronic Publication: 2017 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoiesis*
Megakaryocyte Progenitor Cells/*cytology
Megakaryocyte Progenitor Cells/*metabolism
Megakaryocytes/*cytology
Adult ; Animals ; Antigens, CD/analysis ; Cell Lineage ; Cells, Cultured ; Humans ; Megakaryocyte Progenitor Cells/pathology ; Megakaryocytes/metabolism ; Mice, Inbred C57BL ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/pathology ; Platelet Membrane Glycoprotein IIb/analysis ; Transcriptome
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors.
Autorzy :
Draper JE; Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.
Sroczynska P; Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.; Biotech Research and Innovation Center and.; Center for Epigenetics, University of Copenhagen, Copenhagen, Denmark; and.
Leong HS; Cancer Research UK Applied Computational Biology and Bioinformatics Group, Cancer Research UK Manchester Institute and.
Fadlullah MZH; Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.
Miller C; Cancer Research UK Applied Computational Biology and Bioinformatics Group, Cancer Research UK Manchester Institute and.
Kouskoff V; Division of Developmental Biology & Medicine, The University of Manchester, Manchester, United Kingdom.
Lacaud G; Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.
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Źródło :
Blood [Blood] 2017 Jul 20; Vol. 130 (3), pp. 271-284. Date of Electronic Publication: 2017 May 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis Regulatory Proteins/*genetics
Core Binding Factor Alpha 2 Subunit/*genetics
Megakaryocyte Progenitor Cells/*metabolism
Megakaryocytes/*metabolism
RNA, Messenger/*genetics
Thrombocytopenia/*genetics
Thrombopoiesis/*genetics
Amino Acid Sequence ; Animals ; Apoptosis Regulatory Proteins/metabolism ; Cell Death ; Cell Lineage/genetics ; Cell Proliferation ; Core Binding Factor Alpha 2 Subunit/metabolism ; Flow Cytometry ; Gene Expression Regulation ; Humans ; Immunophenotyping ; Megakaryocyte Progenitor Cells/pathology ; Megakaryocytes/pathology ; Mice ; Mice, Transgenic ; Promoter Regions, Genetic ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Messenger/metabolism ; Thrombocytopenia/metabolism ; Thrombocytopenia/pathology
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 3893

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