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Tytuł :
Oral exposure to BDE-209 modulates metastatic spread of melanoma in C57BL/6 mice inoculated with B16-F10 cells.
Autorzy :
Brito PM; Laboratório de Toxicologia Celular, Departamento de Biologia Celular, Universidade Federal Do Paraná, CEP 81.531-980, Curitiba, Brazil.
Biscaia SMP; Laboratório de Investigações de Polissacarídeos Sulfatados, Departamento de Biologia Celular, Universidade Federal Do Paraná, CEP 81.531-980, Curitiba, Brazil.
de Souza TL; Laboratório de Toxicologia Celular, Departamento de Biologia Celular, Universidade Federal Do Paraná, CEP 81.531-980, Curitiba, Brazil.
Ramos AB; Laboratório de Toxicologia Celular, Departamento de Biologia Celular, Universidade Federal Do Paraná, CEP 81.531-980, Curitiba, Brazil.
Leão-Buchir J; Laboratório de Toxicologia Celular, Departamento de Biologia Celular, Universidade Federal Do Paraná, CEP 81.531-980, Curitiba, Brazil.
de Almeida Roque A; Laboratório de Toxicologia Celular, Departamento de Biologia Celular, Universidade Federal Do Paraná, CEP 81.531-980, Curitiba, Brazil.
de Lima Bellan D; Laboratório de Investigações de Polissacarídeos Sulfatados, Departamento de Biologia Celular, Universidade Federal Do Paraná, CEP 81.531-980, Curitiba, Brazil.
da Silva Trindade E; Laboratório de Investigações de Polissacarídeos Sulfatados, Departamento de Biologia Celular, Universidade Federal Do Paraná, CEP 81.531-980, Curitiba, Brazil.
Filipak Neto F; Laboratório de Toxicologia Celular, Departamento de Biologia Celular, Universidade Federal Do Paraná, CEP 81.531-980, Curitiba, Brazil.
de Oliveira Ribeiro CA; Laboratório de Toxicologia Celular, Departamento de Biologia Celular, Universidade Federal Do Paraná, CEP 81.531-980, Curitiba, Brazil. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2020 Dec; Vol. 260, pp. 127556. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article
MeSH Terms :
Mice, Inbred C57BL*
Halogenated Diphenyl Ethers/*pharmacology
Melanoma/*pathology
Neoplasm Metastasis/*pathology
Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Flame Retardants/pharmacology ; Halogenated Diphenyl Ethers/toxicity ; Heterografts ; Humans ; Liver/drug effects ; Liver/pathology ; Melanoma, Experimental ; Mice
Czasopismo naukowe
Tytuł :
[A case of meningeal melanomatosis diagnosed by immunostaining of cerebrospinal fluid].
Autorzy :
Tamura Y; Department of Neurology, Nagaoka Red Cross Hospital.
Umeda Y; Department of Neurology, Nagaoka Red Cross Hospital.
Umeda M; Department of Neurology, Nagaoka Red Cross Hospital.
Oyake M; Department of Neurology, Nagaoka Red Cross Hospital.
Usuda H; Department of Pathology, Nagaoka Red Cross Hospital.
Fujita N; Department of Neurology, Nagaoka Red Cross Hospital.
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Źródło :
Rinsho shinkeigaku = Clinical neurology [Rinsho Shinkeigaku] 2020 Aug 07; Vol. 60 (8), pp. 565-568. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article
MeSH Terms :
Cerebrospinal Fluid*
Biomarkers, Tumor/*cerebrospinal fluid
Cytodiagnosis/*methods
Melanoma/*cerebrospinal fluid
Melanoma/*diagnosis
Meningeal Carcinomatosis/*cerebrospinal fluid
Meningeal Carcinomatosis/*diagnosis
Meningeal Neoplasms/*cerebrospinal fluid
Meningeal Neoplasms/*diagnosis
Staining and Labeling/*methods
Aged ; Female ; Humans ; Melanoma-Specific Antigens/cerebrospinal fluid ; Neoplasms, Unknown Primary ; S100 Proteins/cerebrospinal fluid
Czasopismo naukowe
Tytuł :
Multifunctional biomimetic nanoparticles loading baicalin for polarizing tumor-associated macrophages.
Autorzy :
Han S; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, P. R. China. , Chinese Academy of Sciences, Beijing 100190, P.R. China. .
Wang W; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, P. R. China. .
Wang S; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, P. R. China. .
Wang S; Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China. .
Ju R; Beijing Institute of Petrochemical Technology, Beijing 102617, P.R. China.
Pan Z; Beijing Institute of Petrochemical Technology, Beijing 102617, P.R. China.
Yang T; Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China. .
Zhang G; Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China. .
Wang H; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, P. R. China. .
Wang L; Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China. .
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Źródło :
Nanoscale [Nanoscale] 2019 Nov 14; Vol. 11 (42), pp. 20206-20220. Date of Electronic Publication: 2019 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Biomimetic Materials*/chemistry
Biomimetic Materials*/pharmacology
Flavonoids*/chemistry
Flavonoids*/pharmacology
Macrophages*/immunology
Macrophages*/pathology
Melanoma, Experimental*/immunology
Melanoma, Experimental*/pathology
Melanoma, Experimental*/therapy
Immunity, Cellular/*drug effects
Nanoparticles/*chemistry
Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; Female ; Melanoma-Specific Antigens/chemistry ; Melanoma-Specific Antigens/pharmacology ; Mice ; Oligodeoxyribonucleotides/chemistry ; Oligodeoxyribonucleotides/pharmacology ; Peptides/chemistry ; Peptides/pharmacology ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Interleukin-9 Inhibits Lung Metastasis of Melanoma through Stimulating Anti-Tumor M1 Macrophages.
Autorzy :
Park SM; Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Korea.
Do-Thi VA; Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Korea.
Lee JO; Department of Life Sciences, POSTECH, Pohang 37673, Korea.
Lee H; Institute of Biotechnology, Chungnam National University, Daejeon 34134, Korea.
Kim YS; Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Korea.
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Źródło :
Molecules and cells [Mol Cells] 2020 May 31; Vol. 43 (5), pp. 479-490.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-9/*metabolism
Lung Neoplasms/*immunology
Macrophages/*immunology
Melanoma/*immunology
Neoplasms, Experimental/*immunology
Animals ; Cytokines/metabolism ; Female ; Humans ; Lung Neoplasms/secondary ; Lung Neoplasms/therapy ; Macrophage Activation ; Melanoma/pathology ; Melanoma, Experimental ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis ; Neoplasms, Experimental/pathology ; Th1 Cells/immunology
Czasopismo naukowe
Tytuł :
Interim analysis for post-marketing surveillance of dabrafenib and trametinib combination therapy in Japanese patients with unresectable and metastatic melanoma with BRAF V600 mutation.
Autorzy :
Teshima Y; Re-Examination, Patient Safety Japan Re-Examination, Regulatory Office Japan, Novartis Pharma K.K., Toranomon Hills Mori Tower, 1-23-1, Toranomon, Minato-ku, Tokyo, 105-6333, Japan. .
Kizaki M; PVO Japan, Patient Safety Japan, Regulatory Office Japan, Novartis Pharma K.K., Toranomon Hills Mori Tower, 1-23-1, Toranomon, Minato-ku, Tokyo, 105-6333, Japan.
Kurihara R; Biostatistics, Clinical Development, Novartis Pharma K.K., Toranomon Hills Mori Tower, 1-23-1, Toranomon, Minato-ku, Tokyo, 105-6333, Japan.
Kano R; Solid Tumor Medical Franchise Department, Oncology Medical Affairs Department, Novartis Pharma K.K., Toranomon Hills Mori Tower, 1-23-1, Toranomon, Minato-ku, Tokyo, 105-6333, Japan.
Harumiya M; Clinical Development of Solid Tumor Oncology Group, Clinical Development Department, Novartis Pharma K.K., Toranomon Hills Mori Tower, 1-23-1, Toranomon, Minato-ku, Tokyo, 105-6333, Japan.
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Źródło :
International journal of clinical oncology [Int J Clin Oncol] 2020 Oct; Vol. 25 (10), pp. 1870-1878. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*adverse effects
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Melanoma/*drug therapy
Melanoma/*genetics
Proto-Oncogene Proteins B-raf/*genetics
Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group ; Female ; Fever/chemically induced ; Humans ; Imidazoles/administration & dosage ; Male ; Melanoma/mortality ; Melanoma/pathology ; Middle Aged ; Mutation ; Oximes/administration & dosage ; Pregnancy ; Progression-Free Survival ; Pyridones/administration & dosage ; Pyrimidinones/administration & dosage ; Surveys and Questionnaires ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Defining an amyloid link Between Parkinson's disease and melanoma.
Autorzy :
Dean DN; Laboratory of Protein Conformation and Dynamics, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Lee JC; Laboratory of Protein Conformation and Dynamics, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 15; Vol. 117 (37), pp. 22671-22673. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Melanoma/*metabolism
Parkinson Disease/*metabolism
alpha-Synuclein/*metabolism
gp100 Melanoma Antigen/*metabolism
Cell Line, Tumor ; Humans ; Melanoma/genetics ; Melanosomes/chemistry ; Melanosomes/genetics ; Melanosomes/metabolism ; Parkinson Disease/genetics ; Protein Aggregates ; Protein Domains ; alpha-Synuclein/chemistry ; alpha-Synuclein/genetics ; gp100 Melanoma Antigen/chemistry ; gp100 Melanoma Antigen/genetics
Czasopismo naukowe
Tytuł :
Metastasectomy for melanoma is associated with improved overall survival in responders to targeted molecular or immunotherapy.
Autorzy :
Medina BD; Division of Surgical Oncology, Department of Surgery, New York University Langone Health, New York, New York.
Choi BH; Division of Surgical Oncology, Department of Surgery, New York University Langone Health, New York, New York.
Rodogiannis KG; Interdisciplinary Melanoma Cooperative Group, New York University Langone Health, New York, New York.
Moran U; Interdisciplinary Melanoma Cooperative Group, New York University Langone Health, New York, New York.; Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York, New York.
Shapiro RL; Division of Surgical Oncology, Department of Surgery, New York University Langone Health, New York, New York.; Interdisciplinary Melanoma Cooperative Group, New York University Langone Health, New York, New York.
Pavlick A; Interdisciplinary Melanoma Cooperative Group, New York University Langone Health, New York, New York.; Division of Hematology and Oncology, Department of Medicine, New York University Langone Health, New York, New York.
Osman I; Interdisciplinary Melanoma Cooperative Group, New York University Langone Health, New York, New York.; Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York, New York.
Berman RS; Division of Surgical Oncology, Department of Surgery, New York University Langone Health, New York, New York.; Interdisciplinary Melanoma Cooperative Group, New York University Langone Health, New York, New York.
Lee AY; Division of Surgical Oncology, Department of Surgery, New York University Langone Health, New York, New York.; Interdisciplinary Melanoma Cooperative Group, New York University Langone Health, New York, New York.
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Źródło :
Journal of surgical oncology [J Surg Oncol] 2020 Sep; Vol. 122 (3), pp. 555-561. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article
MeSH Terms :
Melanoma/*secondary
Melanoma/*therapy
Female ; Humans ; Immunotherapy/methods ; Male ; Melanoma/mortality ; Melanoma/surgery ; Metastasectomy ; Molecular Targeted Therapy/methods ; Neoplasm Staging ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Mohs micrographic surgery versus wide local excision for head and neck melanoma- in-situ .
Autorzy :
Phan K; Department of Dermatology, Liverpool Hospital, Liverpool, Australia.; South Western Sydney Clinical School, University of New South Wales (UNSW), Liverpool, Australia.
Onggo J; Box Hill Hospital, Melbourne, Australia.
Loya A; Baylor College of Medicine, Houston, TX, USA.
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Źródło :
The Journal of dermatological treatment [J Dermatolog Treat] 2020 Sep; Vol. 31 (6), pp. 559-562. Date of Electronic Publication: 2019 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Mohs Surgery*
Head and Neck Neoplasms/*surgery
Melanoma/*surgery
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/pathology ; Humans ; Infant ; Infant, Newborn ; Male ; Melanoma/mortality ; Melanoma/pathology ; Middle Aged ; Proportional Hazards Models ; Registries ; Retrospective Studies ; Survival Rate ; Young Adult
Czasopismo naukowe
Tytuł :
Higher BMI, But Not Sarcopenia, Is Associated With Pembrolizumab-related Toxicity in Patients With Advanced Melanoma.
Autorzy :
Hu JB; Duke University School of Medicine, Duke University Medical Center, Durham, NC, U.S.A.
Ravichandran S; Duke University School of Medicine, Duke University Medical Center, Durham, NC, U.S.A.
Rushing C; Duke Cancer Institute, Duke University Medical Center, Durham, NC, U.S.A.; Biostatistics Shared Resource, Durham, NC, U.S.A.
Beasley GM; Department of Surgery, Duke University Medical Center, Durham, NC, U.S.A.
Hanks BA; Department of Medicine, Division of Medical Oncology and Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, U.S.A.
Jung SH; Duke Cancer Institute, Duke University Medical Center, Durham, NC, U.S.A.; Biostatistics Shared Resource, Durham, NC, U.S.A.
Salama AKS; Department of Medicine, Division of Medical Oncology and Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, U.S.A.
Ho L; Duke Radiology, Duke University Medical Center, Durham, NC, U.S.A.
Mosca PJ; Department of Surgery, Duke University Medical Center, Durham, NC, U.S.A. .
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Źródło :
Anticancer research [Anticancer Res] 2020 Sep; Vol. 40 (9), pp. 5245-5254.
Typ publikacji :
Journal Article
MeSH Terms :
Body Mass Index*
Antibodies, Monoclonal, Humanized/*adverse effects
Antineoplastic Agents, Immunological/*adverse effects
Drug-Related Side Effects and Adverse Reactions/*etiology
Melanoma/*complications
Melanoma/*drug therapy
Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antineoplastic Agents, Immunological/administration & dosage ; Disease Susceptibility ; Female ; Humans ; Male ; Melanoma/diagnosis ; Melanoma/etiology ; Middle Aged ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography ; Prognosis ; Sarcopenia/complications ; Tomography, X-Ray Computed ; Young Adult
Czasopismo naukowe
Tytuł :
Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.
Autorzy :
Baumann T; Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Dunkel A; Leibniz-Institute of Food Systems Biology, TUM, Munich, Germany.
Schmid C; Food Chemistry and Molecular Sensory Science, TUM, Munich, Germany.
Schmitt S; Institute for Toxicology and Environmental Hygiene, School of Medicine, TUM, Munich, Germany.
Hiltensperger M; Department of Experimental Neuroimmunology, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.
Lohr K; Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Laketa V; Department of Infectious Diseases, German Center for Infection Research, Heidelberg University, Heidelberg, Germany.
Donakonda S; Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Ahting U; Institute of Human Genetics, Stoffwechselzentrum, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.
Lorenz-Depiereux B; Institute of Human Genetics, Helmholtz Zentrum München, Munich, Germany.
Heil JE; Carl Zeiss Microscopy, Göttingen, Germany.
Schredelseker J; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Simeoni L; Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, Germany.
Fecher C; Institute of Neuronal Cell Biology, TUM, Munich Cluster for Systems Neurology and German Center for Neurodegenerative Diseases, Munich, Germany.
Körber N; Institute of Virology, Helmholtz Zentrum München, Munich, Germany.
Bauer T; Institute of Virology, Helmholtz Zentrum München, Munich, Germany.
Hüser N; Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.
Hartmann D; Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.
Laschinger M; Department of Surgery, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.
Eyerich K; Department of Dermatology and Allergy, TUM, Munich, Germany.
Eyerich S; Center of Allergy and Environment, TUM and Helmholtz Zentrum München, Munich, Germany.
Anton M; Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Streeter M; Department of Chemistry, Yale University, New Haven, CT, USA.
Wang T; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Schraven B; Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, Germany.
Spiegel D; Department of Chemistry, Yale University, New Haven, CT, USA.; Department of Pharmacology, Yale University, New Haven, CT, USA.
Assaad F; Research Department Plant Sciences, Center for Life Science, TUM, Munich, Germany.
Misgeld T; Institute of Neuronal Cell Biology, TUM, Munich Cluster for Systems Neurology and German Center for Neurodegenerative Diseases, Munich, Germany.
Zischka H; Institute for Toxicology and Environmental Hygiene, School of Medicine, TUM, Munich, Germany.; Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Neuherberg, Germany.
Murray PJ; Max Planck Institute of Biochemistry, Munich, Germany.
Heine A; Medical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany.; Institute of Experimental Immunology, University Bonn, Bonn, Germany.
Heikenwälder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.
Korn T; Department of Experimental Neuroimmunology, Klinikum Rechts der Isar, School of Medicine, TUM, Munich, Germany.
Dawid C; Food Chemistry and Molecular Sensory Science, TUM, Munich, Germany.
Hofmann T; Leibniz-Institute of Food Systems Biology, TUM, Munich, Germany.; Food Chemistry and Molecular Sensory Science, TUM, Munich, Germany.
Knolle PA; Institute of Molecular Immunology and Experimental Oncology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany. .; Institute of Molecular Immunology, School of Life Sciences, TUM, Munich, Germany. .; German Center for Infection Research, Munich, Germany. .
Höchst B; Institute of Molecular Immunology, School of Life Sciences, TUM, Munich, Germany. .
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Źródło :
Nature immunology [Nat Immunol] 2020 May; Vol. 21 (5), pp. 555-566. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Immunotherapy/*methods
Melanoma/*immunology
Myeloid-Derived Suppressor Cells/*immunology
Pyruvaldehyde/*metabolism
Amine Oxidase (Copper-Containing)/metabolism ; Animals ; CD8-Positive T-Lymphocytes/transplantation ; Cell Communication ; Cell Proliferation ; Humans ; Immune Tolerance ; Lymphocyte Activation ; Melanoma, Experimental ; Mice ; Mice, Transgenic ; Neoplasms, Experimental ; Programmed Cell Death 1 Receptor/metabolism
Czasopismo naukowe
Tytuł :
Organogold drug Auranofin exhibits anti-melanogenic activity in B16F10 and MNT-1 melanoma cells.
Autorzy :
Goenka S; Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, 11794-5281, USA. .
Simon SR; Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, 11794-5281, USA.; Department of Pathology, Stony Brook University, Stony Brook, NY, USA.; Department of Biochemistry and Cellular Biology, Stony Brook University, Stony Brook, NY, USA.
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Źródło :
Archives of dermatological research [Arch Dermatol Res] 2020 Apr; Vol. 312 (3), pp. 213-221. Date of Electronic Publication: 2019 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Auranofin/*therapeutic use
Hyperpigmentation/*drug therapy
Melanins/*metabolism
Melanoma/*drug therapy
Skin Neoplasms/*drug therapy
Animals ; Drug Repositioning ; Humans ; Melanoma, Experimental ; Mice ; Monophenol Monooxygenase/metabolism ; Rheumatic Diseases/drug therapy ; Signal Transduction ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Tytuł :
Efficacy of Electrochemotherapy in the Treatment of Cutaneous Melanoma Metastases and Rare Non-melanoma Skin Cancer.
Autorzy :
Borgognoni L; Department of Plastic and Reconstructive Surgery, Melanoma and Skin Cancer Unit, Regional Melanoma Referral Center, S.M. Annunziata Hospital, Florence, Italy.
Pescitelli L; Dermatology Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
Gerlini G; Department of Plastic and Reconstructive Surgery, Melanoma and Skin Cancer Unit, Regional Melanoma Referral Center, S.M. Annunziata Hospital, Florence, Italy.
Brandani P; Department of Plastic and Reconstructive Surgery, Melanoma and Skin Cancer Unit, Regional Melanoma Referral Center, S.M. Annunziata Hospital, Florence, Italy.
Gelli R; Department of Plastic and Reconstructive Surgery, Melanoma and Skin Cancer Unit, Regional Melanoma Referral Center, S.M. Annunziata Hospital, Florence, Italy.
Giannotti V; Department of Plastic and Reconstructive Surgery, Melanoma and Skin Cancer Unit, Regional Melanoma Referral Center, S.M. Annunziata Hospital, Florence, Italy.
Bellucci F; Department of Plastic and Reconstructive Surgery, Melanoma and Skin Cancer Unit, Regional Melanoma Referral Center, S.M. Annunziata Hospital, Florence, Italy.
Sestini S; Department of Plastic and Reconstructive Surgery, Melanoma and Skin Cancer Unit, Regional Melanoma Referral Center, S.M. Annunziata Hospital, Florence, Italy .
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Źródło :
Anticancer research [Anticancer Res] 2020 Nov; Vol. 40 (11), pp. 6485-6492.
Typ publikacji :
Journal Article
MeSH Terms :
Electrochemotherapy*
Melanoma/*therapy
Neoplasms, Second Primary/*therapy
Skin Neoplasms/*therapy
Adult ; Bleomycin/administration & dosage ; Carcinoma, Merkel Cell ; Female ; Humans ; Italy/epidemiology ; Male ; Melanoma/pathology ; Middle Aged ; Neoplasms, Second Primary/pathology ; Remission Induction ; Skin Neoplasms/pathology ; Treatment Outcome
SCR Disease Name :
Melanoma, Cutaneous Malignant
Czasopismo naukowe
Tytuł :
Loss-of-function variants in FSIP1 identified by targeted sequencing are associated with one particular subtype of mucosal melanoma.
Autorzy :
Chen M; Institute of Dermatology and Department of Dermatology the first Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China; School of Life Sciences, Anhui Medical University, Hefei, Anhui, China.
Wu Y; Department of Oncology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China; School of Life Sciences, Anhui Medical University, Hefei, Anhui, China.
Li W; Department of Oncology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China; School of Life Sciences, Anhui Medical University, Hefei, Anhui, China.
Zhang X; Department of Oncology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China; Department of Pathology the first Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
Chen L; Department of Oncology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China.
Zheng X; Institute of Dermatology and Department of Dermatology the first Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
Zuo X; Institute of Dermatology and Department of Dermatology the first Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
Zhou F; Institute of Dermatology and Department of Dermatology the first Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
Hong Y; Department of Oncology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China.
Cheng H; Department of Oncology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China.
Zhang M; Department of Oncology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China.
Chen Z; Department of Oncology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China.
Wu Q; Department of Pathology the first Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
Zhang X; Institute of Dermatology and Department of Dermatology the first Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China. Electronic address: .
Zhang B; Department of Oncology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China; School of Life Sciences, Anhui Medical University, Hefei, Anhui, China. Electronic address: .
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Źródło :
Gene [Gene] 2020 Oct 30; Vol. 759, pp. 144964. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article
MeSH Terms :
Loss of Function Mutation*
Carrier Proteins/*genetics
Melanoma/*genetics
Seminal Plasma Proteins/*genetics
Aged ; Female ; Humans ; Male ; Melanocytes/metabolism ; Melanocytes/pathology ; Melanoma/classification ; Melanoma/pathology ; Middle Aged ; Mucous Membrane/metabolism ; Mucous Membrane/pathology
Czasopismo naukowe
Tytuł :
Prognostic impact of HERC2 protein and pink-eyed dilution protein in uveal melanoma.
Autorzy :
Kashyap S; Department of Ocular Pathology, Dr. R. P. Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.
Singh MK; Department of Ocular Pathology, Dr. R. P. Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.
Jha J; Department of Ocular Pathology, Dr. R. P. Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.
Singh L; Department of Ocular Pathology, Dr. R. P. Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.
Pushker N; Department of Ophthalmology, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Sen S; Department of Ocular Pathology, Dr. R. P. Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.
Venkatesh P; Department of Ophthalmology, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Meel R; Department of Ophthalmology, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Lomi N; Department of Ophthalmology, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences (AIIMS), New Delhi, India. .
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Źródło :
Human cell [Hum Cell] 2020 Oct; Vol. 33 (4), pp. 1264-1272. Date of Electronic Publication: 2020 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*analysis
Guanine Nucleotide Exchange Factors/*analysis
Melanoma/*diagnosis
Membrane Transport Proteins/*analysis
Uveal Neoplasms/*diagnosis
Adult ; Disease-Free Survival ; Female ; Gene Expression ; Guanine Nucleotide Exchange Factors/genetics ; Humans ; Immunohistochemistry ; Male ; Melanoma/genetics ; Melanoma/mortality ; Melanoma/pathology ; Membrane Transport Proteins/genetics ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Uveal Neoplasms/genetics ; Uveal Neoplasms/mortality ; Uveal Neoplasms/pathology
SCR Disease Name :
Uveal melanoma
Czasopismo naukowe
Tytuł :
Intracellular accumulation of PD-1 molecules in circulating T lymphocytes in advanced malignant melanoma: an implication for immune evasion mechanism.
Autorzy :
Takahashi R; Flow Cytometry Core Facility, Kyorin University Graduate School of Medicine, Tokyo, Japan.
Sato Y; Department of Dermatology, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka city, Tokyo, 181-8611, Japan.
Kimishima M; Department of Dermatology, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka city, Tokyo, 181-8611, Japan.
Shiohara T; Flow Cytometry Core Facility, Kyorin University Graduate School of Medicine, Tokyo, Japan.; Department of Dermatology, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka city, Tokyo, 181-8611, Japan.
Ohyama M; Flow Cytometry Core Facility, Kyorin University Graduate School of Medicine, Tokyo, Japan. .; Department of Dermatology, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka city, Tokyo, 181-8611, Japan. .
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Źródło :
International journal of clinical oncology [Int J Clin Oncol] 2020 Oct; Vol. 25 (10), pp. 1861-1869. Date of Electronic Publication: 2020 Jul 12.
Typ publikacji :
Journal Article
MeSH Terms :
Melanoma/*immunology
Nivolumab/*pharmacology
Programmed Cell Death 1 Receptor/*metabolism
T-Lymphocytes/*metabolism
Tumor Escape/*immunology
Antineoplastic Agents, Immunological/pharmacology ; Biomarkers, Tumor/immunology ; Biomarkers, Tumor/metabolism ; Humans ; Immunotherapy/adverse effects ; Melanoma/drug therapy ; Melanoma/metabolism ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Tumor Escape/drug effects
Czasopismo naukowe
Tytuł :
Combined microscope and endoscopy total resection of primary pineal malignant melanoma: case report and literature review.
Autorzy :
Zhang J; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan, 430071, China.; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA.
Xiong Z; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan, 430071, China.
Chen J; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan, 430071, China. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2020 Oct; Vol. 146 (10), pp. 2589-2594. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Brain Neoplasms/*pathology
Brain Neoplasms/*surgery
Melanoma/*pathology
Melanoma/*surgery
Pineal Gland/*pathology
Pineal Gland/*surgery
Aged ; Brain Neoplasms/diagnostic imaging ; Endoscopy/methods ; Humans ; Magnetic Resonance Imaging ; Male ; Melanoma/diagnostic imaging ; Pineal Gland/diagnostic imaging
Czasopismo naukowe
Tytuł :
Immune checkpoint inhibitors reverse tolerogenic mechanisms induced by melanoma targeted radionuclide therapy.
Autorzy :
Rouanet J; UMR1240 INSERM, Université Clermont Auvergne, 58, rue Montalembert, BP 184, 63005, Clermont-Ferrand, France. .; Department of Dermatology and Oncodermatology, CHU Estaing, 1 place Lucie et Raymond Aubrac, 63000, Clermont-Ferrand, France. .; Centre Jean Perrin, 58, rue Montalembert, 63011, Clermont-Ferrand, France. .
Benboubker V; UMR1240 INSERM, Université Clermont Auvergne, 58, rue Montalembert, BP 184, 63005, Clermont-Ferrand, France.; Department of Histocompatibility and Immunogenetics, CHU Gabriel Montpied, 58 rue Montalembert, 63000, Clermont-Ferrand, France.
Akil H; UMR1240 INSERM, Université Clermont Auvergne, 58, rue Montalembert, BP 184, 63005, Clermont-Ferrand, France.
Hennino A; UMR INSERM 1052 CNRS 5286 CRCL, 28 rue Laennec, 69008, Lyon, France.
Auzeloux P; UMR1240 INSERM, Université Clermont Auvergne, 58, rue Montalembert, BP 184, 63005, Clermont-Ferrand, France.
Besse S; UMR1240 INSERM, Université Clermont Auvergne, 58, rue Montalembert, BP 184, 63005, Clermont-Ferrand, France.
Pereira B; Biostatistics Unit, DRCI, CHU Gabriel Montpied, 58 rue Montalembert, 63000, Clermont-Ferrand, France.
Delorme S; UMR1240 INSERM, Université Clermont Auvergne, 58, rue Montalembert, BP 184, 63005, Clermont-Ferrand, France.
Mansard S; Department of Dermatology and Oncodermatology, CHU Estaing, 1 place Lucie et Raymond Aubrac, 63000, Clermont-Ferrand, France.
D'Incan M; UMR1240 INSERM, Université Clermont Auvergne, 58, rue Montalembert, BP 184, 63005, Clermont-Ferrand, France.; Department of Dermatology and Oncodermatology, CHU Estaing, 1 place Lucie et Raymond Aubrac, 63000, Clermont-Ferrand, France.
Degoul F; UMR1240 INSERM, Université Clermont Auvergne, 58, rue Montalembert, BP 184, 63005, Clermont-Ferrand, France.
Rouzaire PO; UMR1240 INSERM, Université Clermont Auvergne, 58, rue Montalembert, BP 184, 63005, Clermont-Ferrand, France.; Department of Histocompatibility and Immunogenetics, CHU Gabriel Montpied, 58 rue Montalembert, 63000, Clermont-Ferrand, France.
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Oct; Vol. 69 (10), pp. 2075-2088. Date of Electronic Publication: 2020 May 23.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Immunological/*therapeutic use
Immunotherapy/*methods
Iodine Radioisotopes/*therapeutic use
Melanoma, Experimental/*immunology
Melanoma, Experimental/*therapy
Radiation Tolerance/*drug effects
Animals ; Combined Modality Therapy ; Melanoma, Experimental/pathology ; Mice ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Melanoma brain metastases - Interdisciplinary management recommendations 2020.
Autorzy :
Gutzmer R; Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Germany. Electronic address: .
Vordermark D; Department for Radiation Oncology, Martin-Luther University Halle-Wittenberg, Halle, Germany.
Hassel JC; Skin Cancer Center, Department of Dermatology and National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.
Krex D; Department of Neurosurgery, Faculty of Medicine and University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Wendl C; Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
Schadendorf D; Department of Dermatology, University Hospital Essen, Essen, Germany.
Sickmann T; Bristol-Myers Squibb GmbH & Co. KGaA, Munich, Germany.
Rieken S; Policlinic for Radiation Therapy and Radiation Oncology, University Hospital Göttingen, Göttingen, Germany.
Pukrop T; Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.
Höller C; Department of Dermatology, Medical University Vienna, Vienna, Austria.
Eigentler TK; Center for Dermatooncology, Department of Dermatology, Eberhard Karls University of Tübingen, Tübingen, Germany.
Meier F; Skin Cancer Center at the University Cancer Centre and National Center for Tumor Diseases, Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
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Źródło :
Cancer treatment reviews [Cancer Treat Rev] 2020 Sep; Vol. 89, pp. 102083. Date of Electronic Publication: 2020 Jul 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain Neoplasms/*secondary
Brain Neoplasms/*therapy
Melanoma/*pathology
Melanoma/*therapy
Animals ; Brain Neoplasms/diagnosis ; Clinical Trials as Topic ; Cohort Studies ; Combined Modality Therapy ; Humans ; Melanoma/diagnosis ; Patient Care Team ; Randomized Controlled Trials as Topic ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Ipsilateral metastatic choroidal melanoma responds to systemic immunotherapy.
Autorzy :
Morkos M; The New York Eye Cancer Center, New York, NY, USA.
Jain P; The New York Eye Cancer Center, New York, NY, USA.
Pavlick AC; Perlmutter Cancer Center, School of Medicine, New York University, New York, NY, USA.
Finger PT; The New York Eye Cancer Center, New York, NY, USA.; Perlmutter Cancer Center, School of Medicine, New York University, New York, NY, USA.
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Źródło :
European journal of ophthalmology [Eur J Ophthalmol] 2020 Sep; Vol. 30 (5), pp. NP69-NP73. Date of Electronic Publication: 2019 Apr 04.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Antineoplastic Agents, Immunological/*therapeutic use
Choroid Neoplasms/*therapy
Immunotherapy/*methods
Liver Neoplasms/*therapy
Lymphatic Metastasis/*therapy
Melanoma/*therapy
Neoplasms, Second Primary/*therapy
Brachytherapy/methods ; Choroid Neoplasms/diagnostic imaging ; Choroid Neoplasms/pathology ; Female ; Follow-Up Studies ; Humans ; Ipilimumab/therapeutic use ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/secondary ; Melanoma/diagnostic imaging ; Melanoma/secondary ; Middle Aged ; Neoplasms, Second Primary/diagnostic imaging ; Neoplasms, Second Primary/secondary ; Nivolumab/therapeutic use ; Positron Emission Tomography Computed Tomography ; Treatment Outcome ; Ultrasonography
Czasopismo naukowe
Tytuł :
'Primum non nocere': how harmless is routine wide local excision for AJCC stage IA melanoma?
Autorzy :
Lau KL; Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Bradish T; Aberdeen Royal Infirmary, Foresterhill Health Campus, Aberdeen, UK.
Rannan-Eliya S; Royal Victoria Infirmary, Newcastle upon Tyne, UK.
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Źródło :
Annals of the Royal College of Surgeons of England [Ann R Coll Surg Engl] 2020 Sep; Vol. 102 (7), pp. 483-487. Date of Electronic Publication: 2020 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Margins of Excision*
Neoplasm Staging*
Surgical Flaps*
Melanoma/*surgery
Reconstructive Surgical Procedures/*methods
Skin Neoplasms/*surgery
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Female ; Follow-Up Studies ; Humans ; Male ; Melanoma/diagnosis ; Middle Aged ; Retrospective Studies ; Skin Neoplasms/diagnosis ; Treatment Outcome ; Young Adult
SCR Disease Name :
Melanoma, Cutaneous Malignant
Czasopismo naukowe

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