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Tytuł :
DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3β signaling in Aβ 25 - 35 treated BV-2 cells.
Autorzy :
Zu HB; Department of Neurology, Jinshan Hospital affiliated to Fudan University, Shanghai 201508, China.
Liu XY; Department of Endoscopy, Jinshan Hospital affiliated to Fudan University, Shanghai 201508, China.
Yao K; Department of Neurology, Jinshan Hospital affiliated to Fudan University, Shanghai 201508, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118470. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Peptides/*pharmacology
Microglia/*drug effects
Microglia/*metabolism
Nerve Tissue Proteins/*genetics
Oxidoreductases Acting on CH-CH Group Donors/*genetics
Peptide Fragments/*pharmacology
Proto-Oncogene Proteins c-akt/*metabolism
Animals ; Cell Line ; Gene Expression Regulation, Enzymologic ; Glycogen Synthase Kinase 3 beta/metabolism ; HEK293 Cells ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Mice ; Microglia/cytology ; Microglia/physiology ; Nerve Tissue Proteins/metabolism ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Inhibiting the Piezo1 channel protects microglia from acute hyperglycaemia damage through the JNK1 and mTOR signalling pathways.
Autorzy :
Liu H; Department of Anesthesiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China; Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, Nanchang, China; Graduate School of School of Medicine, Nanchang University, China.
Bian W; Department of Anesthesiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China; Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, Nanchang, China; Graduate School of School of Medicine, Nanchang University, China.
Yang D; Department of Anesthesiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China; Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, Nanchang, China; Graduate School of School of Medicine, Nanchang University, China.
Yang M; Department of Anesthesiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China.
Luo H; Department of Anesthesiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118667. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*/drug effects
Hyperglycemia/*metabolism
Hyperglycemia/*pathology
Ion Channels/*antagonists & inhibitors
Microglia/*metabolism
Microglia/*pathology
Mitogen-Activated Protein Kinase 8/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Acute Disease ; Animals ; Calcium/metabolism ; Cell Line ; Cytosol/metabolism ; Glucose/toxicity ; Inflammation Mediators/metabolism ; Ion Channels/metabolism ; Lipopolysaccharides ; Mice ; Microglia/drug effects
Czasopismo naukowe
Tytuł :
Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system.
Autorzy :
Mangale V; Division of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Syage AR; Department of Neurobiology & Behavior, School of Biological Sciences, University of California, Irvine, California, USA.
Ekiz HA; Division of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Skinner DD; Division of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Cheng Y; Department of Neurobiology & Behavior, School of Biological Sciences, University of California, Irvine, California, USA.
Stone CL; Division of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Brown RM; Division of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
O'Connell RM; Division of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Green KN; Department of Neurobiology & Behavior, School of Biological Sciences, University of California, Irvine, California, USA.
Lane TE; Department of Neurobiology & Behavior, School of Biological Sciences, University of California, Irvine, California, USA.
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Źródło :
Glia [Glia] 2020 Nov; Vol. 68 (11), pp. 2345-2360. Date of Electronic Publication: 2020 May 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Brain/*immunology
Coronavirus Infections/*immunology
Host-Pathogen Interactions/*immunology
Microglia/*immunology
Murine hepatitis virus/*immunology
Organic Chemicals/*toxicity
Animals ; Brain/drug effects ; Brain/virology ; Coronavirus Infections/chemically induced ; Host-Pathogen Interactions/drug effects ; Immunity, Cellular/drug effects ; Immunity, Cellular/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/drug effects ; Microglia/virology
Czasopismo naukowe
Tytuł :
Salvianolate reduces neuronal apoptosis by suppressing OGD-induced microglial activation.
Autorzy :
Luan P; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional, Chinese Medicine (IRI), Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Ding X; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional, Chinese Medicine (IRI), Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Xu J; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional, Chinese Medicine (IRI), Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Jiang L; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional, Chinese Medicine (IRI), Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Xu Y; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional, Chinese Medicine (IRI), Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Zhu Y; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional, Chinese Medicine (IRI), Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Li R; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional, Chinese Medicine (IRI), Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhang J; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional, Chinese Medicine (IRI), Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118393. Date of Electronic Publication: 2020 Sep 06.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Glucose/*deficiency
Microglia/*drug effects
Neurons/*drug effects
Neuroprotective Agents/*pharmacology
Oxygen/*metabolism
Plant Extracts/*pharmacology
Animals ; Cells, Cultured ; Cytokines/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Mice ; Microglia/metabolism ; Microglia/pathology ; Neurons/metabolism ; Neurons/pathology ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFκB signaling pathway.
Autorzy :
Yang L; Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Han X; Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Xing F; Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Wu H; Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Shi H; Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Huang F; Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Xu Q; School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: .
Wu X; Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Jan; Vol. 80, pp. 153385. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Astragalus Plant/*chemistry
Encephalomyelitis, Autoimmune, Experimental/*drug therapy
Flavonoids/*pharmacology
Microglia/*drug effects
Animals ; Cell Line ; Cytokines/metabolism ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Female ; Flavonoids/chemistry ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation Mediators/metabolism ; Lipopolysaccharides/pharmacology ; MAP Kinase Signaling System/drug effects ; Mice, Inbred C57BL ; Microglia/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; Spinal Cord/physiopathology
Czasopismo naukowe
Tytuł :
Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells.
Autorzy :
Priya R; Department of Microbiology and Immunology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States. Electronic address: .
Brutkiewicz RR; Department of Microbiology and Immunology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States. Electronic address: .
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Źródło :
Journal of neuroimmunology [J Neuroimmunol] 2020 Dec 15; Vol. 349, pp. 577428. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Brain/*metabolism
Histocompatibility Antigens Class I/*biosynthesis
Immunity, Innate/*physiology
Microglia/*metabolism
Minor Histocompatibility Antigens/*biosynthesis
Mucosal-Associated Invariant T Cells/*metabolism
Animals ; Astrocytes/immunology ; Brain/immunology ; Cell Line ; Female ; Histocompatibility Antigens Class I/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/immunology ; Minor Histocompatibility Antigens/immunology ; Mucosal-Associated Invariant T Cells/immunology
Czasopismo naukowe
Tytuł :
The protective effect of 5-O-methylvisammioside on LPS-induced depression in mice by inhibiting the over activation of BV-2 microglia through Nf-κB/IκB-α pathway.
Autorzy :
Sun X; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Zhang T; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Zhao Y; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China. Electronic address: .
Cai E; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Zhu H; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Liu S; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China; National & Local Joint Engineering Research Center for Ginseng Breeding and Application, Jilin Agricultural University, Changchun, Jilin, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2020 Dec; Vol. 79, pp. 153348. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antidepressive Agents/*pharmacology
Depression/*drug therapy
Drugs, Chinese Herbal/*pharmacology
Microglia/*drug effects
Neuroprotective Agents/*pharmacology
Animals ; Antidepressive Agents/chemistry ; Behavior, Animal/drug effects ; Brain/drug effects ; Brain/metabolism ; Cell Line ; Cytokines/blood ; Depression/chemically induced ; Depression/metabolism ; Lipopolysaccharides/toxicity ; Male ; Mice, Inbred ICR ; Microglia/metabolism ; NF-KappaB Inhibitor alpha/metabolism ; NF-kappa B/metabolism ; Neuroprotective Agents/chemistry ; Nitric Oxide/metabolism ; Phosphorylation/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Enhancement of lens extraction-induced MCP-1 upregulation and microglia response in long-term diabetes via c-jun, stat1 and ERK.
Autorzy :
Tang Y; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Yin H; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Wang W; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Zhang X; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Chu N; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Li S; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Yan C; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Fu Q; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Yao K; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 15; Vol. 261, pp. 118360. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article
MeSH Terms :
Cataract Extraction*
MAP Kinase Signaling System*/drug effects
Chemokine CCL2/*metabolism
Diabetes Mellitus, Experimental/*genetics
Microglia/*pathology
Proto-Oncogene Proteins c-jun/*metabolism
STAT1 Transcription Factor/*metabolism
Up-Regulation/*genetics
Animals ; Glucose/toxicity ; Inflammation/genetics ; Inflammation/pathology ; Lipopolysaccharides/pharmacology ; Macrophage Activation/drug effects ; Macrophages/metabolism ; Macrophages/pathology ; Male ; Mice, Inbred C57BL ; Microglia/drug effects ; Microglia/metabolism ; Retina/pathology ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Exosomes from MSCs overexpressing microRNA-223-3p attenuate cerebral ischemia through inhibiting microglial M1 polarization mediated inflammation.
Autorzy :
Zhao Y; School of Clinical Sciences, Hangzhou Medical College, Zhejiang, China.
Gan Y; School of Pharmaceutical Sciences, Hangzhou Medical College, Zhejiang, China.
Xu G; School of Clinical Sciences, Hangzhou Medical College, Zhejiang, China.
Hua K; School of Basic Medical Sciences & Forensic Medicine, Hangzhou Medical College, Zhejiang, China.
Liu D; School of Basic Medical Sciences & Forensic Medicine, Hangzhou Medical College, Zhejiang, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118403. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Ischemia/*prevention & control
Exosomes/*genetics
Inflammation/*prevention & control
MicroRNAs/*genetics
Microglia/*metabolism
Reperfusion Injury/*prevention & control
Animals ; Brain Ischemia/etiology ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; Infarction, Middle Cerebral Artery/complications ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation/pathology ; Male ; Microglia/immunology ; Microglia/pathology ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/etiology ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology
Czasopismo naukowe
Tytuł :
[Aldo-keto reductase 1 member B1 (AKR1B1) inhibits retinal ganglion cell activity via activating NF-κB pathway and inducing mouse BV-2 microglia activation].
Autorzy :
Bai Q; Department of ENT, Hospital of 26th Base of PLA Strategic Support Force, Xi'an 710043; Department of Ophthalmology, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
Wang X; Rehabilitation Center of Lintong Sanatorium of PLA, Xi'an 710600, China.
Mao X; Department of Periodontology, Stomatological Hospital, Air Force Medical University, Xi'an 710032, China.
Hu D; Department of Ophthalmology, Xijing Hospital, Air Force Medical University, Xi'an 710032, China. *Corresponding author, E-mail: .
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2020 Dec; Vol. 36 (12), pp. 1063-1068.
Typ publikacji :
Journal Article
MeSH Terms :
Microglia*/metabolism
Aldo-Keto Reductases ; Animals ; Cell Line ; Inflammation ; Lipopolysaccharides ; Mice ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Retinal Ganglion Cells/metabolism ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
The potential role of inflammation reaction in COVID-19 related posttraumatic stress disorder.
Autorzy :
Jiang Y; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, PR China.
Huang Z; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, PR China.
Mi L; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, PR China.
Zhou Y; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, PR China. Electronic address: .
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Źródło :
Asian journal of psychiatry [Asian J Psychiatr] 2020 Dec; Vol. 54, pp. 102405. Date of Electronic Publication: 2020 Aug 29.
Typ publikacji :
Letter
MeSH Terms :
Astrocytes/*immunology
Brain/*immunology
COVID-19/*immunology
Cytokines/*immunology
Inflammation/*immunology
Microglia/*immunology
Stress Disorders, Post-Traumatic/*immunology
Astrocytes/metabolism ; Glucocorticoids/immunology ; Glucocorticoids/metabolism ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Learning/physiology ; Memory/physiology ; Microglia/metabolism ; Neurogenesis/immunology ; Neuronal Plasticity/immunology ; Quinolinic Acid/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Serotonin/metabolism ; Stress Disorders, Post-Traumatic/metabolism
Opinia redakcyjna
Tytuł :
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease.
Autorzy :
Olah M; Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
Menon V; Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
Habib N; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.; Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Taga MF; Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
Ma Y; Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
Yung CJ; Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA.
Cimpean M; Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA.
Khairallah A; Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA.
Coronas-Samano G; Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
Sankowski R; Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.; Berta-Ottenstein-Programme for Clinician Scientists, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Grün D; Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Kroshilina AA; Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA.
Dionne D; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
Sarkis RA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Cosgrove GR; Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA.
Helgager J; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Golden JA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Pennell PB; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Prinz M; Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.; Signaling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Center for NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Vonsattel JPG; Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
Teich AF; Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Regev A; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, MA, 02140, USA.; Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA.
Elyaman W; Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
Bradshaw EM; Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
De Jager PL; Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA. .; Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Medical Center, New York, NY, USA. .; Department of Neurology, Columbia University Medical Center, New York, NY, USA. .; Cell Circuits Program, Broad Institute, Cambridge, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 30; Vol. 11 (1), pp. 6129. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*metabolism
Microglia/*metabolism
Alzheimer Disease/genetics ; Cerebral Cortex/metabolism ; Female ; Humans ; Male ; Microglia/pathology ; Myeloid Cells ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Anti-inflammatory effects of vinpocetine in LPS-stimulated microglia via activation of AMPK.
Autorzy :
Zhou Q; Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, 215002, P.R. China.
Guo D; Department of pharmacy, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, 215153, P.R. China.; Jiangsu Key Laboratory of Neuropsychiatric Diseases Research and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215021, P.R. China.
Li X; Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, 215002, P.R. China.
Wang Y; Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, 215002, P.R. China.
Ye X; Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, 215002, P.R. China.
Xue S; Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, 215002, P.R. China.
Wang X; Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, 215002, P.R. China.
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Źródło :
Anais da Academia Brasileira de Ciencias [An Acad Bras Cienc] 2020 Nov 20; Vol. 92 (4), pp. e20200241. Date of Electronic Publication: 2020 Nov 20 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Lipopolysaccharides*/pharmacology
Microglia*
AMP-Activated Protein Kinases ; Anti-Inflammatory Agents/pharmacology ; Cyclooxygenase 2 ; Nitric Oxide ; Vinca Alkaloids
Czasopismo naukowe
Tytuł :
Microglia Tweak Retinogeniculate Pathways during Visual Circuit Refinement.
Autorzy :
Keck T; Department of Neuroscience, Physiology and Pharmacology, University College London, 21 University St., London WC1E 6DE, UK. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Nov 11; Vol. 108 (3), pp. 397-399.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Microglia*
Tumor Necrosis Factors*
Receptors, Tumor Necrosis Factor ; TWEAK Receptor/genetics
Czasopismo naukowe
Tytuł :
The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu).
Autorzy :
Alghamdi A; Biochemistry Department, King Saud University (KSU), Riyadh, Saudi Arabia.
Aldossary W; Biochemistry Department, King Saud University (KSU), Riyadh, Saudi Arabia.
Albahkali S; Stem Cells and Regenerative Medicine, King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.
Alotaibi B; Stem Cells and Regenerative Medicine, King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.
Alrfaei BM; Stem Cells and Regenerative Medicine, King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.; King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.
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Źródło :
PloS one [PLoS One] 2020 Nov 10; Vol. 15 (11), pp. e0241902. Date of Electronic Publication: 2020 Nov 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Point Mutation*
Astrocytes/*cytology
Cytochrome P-450 CYP1B1/*genetics
Glaucoma/*congenital
Mesenchymal Stem Cells/*cytology
Microglia/*cytology
Amino Acid Substitution ; Animals ; Apoptosis ; Astrocytes/metabolism ; CRISPR-Cas Systems ; Cell Proliferation ; Cells, Cultured ; Cytokines/metabolism ; Glaucoma/genetics ; Humans ; Male ; Mesenchymal Stem Cells/metabolism ; Microglia/metabolism ; Models, Animal ; NADP/metabolism ; Rats
Czasopismo naukowe
Tytuł :
Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.
Autorzy :
Chiot A; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.
Zaïdi S; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.
Iltis C; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.
Ribon M; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.
Berriat F; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.
Schiaffino L; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.; Department of Neurological, Biomedical and Movement Science, University of Verona, Verona, Italy.
Jolly A; Genosplice, Paris, France.
de la Grange P; Genosplice, Paris, France.
Mallat M; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.
Bohl D; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.
Millecamps S; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.
Seilhean D; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.; Département de Neuropathologie, APHP, Hôpital Pitié-Salpêtrière, Paris, France.
Lobsiger CS; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.
Boillée S; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France. .
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Źródło :
Nature neuroscience [Nat Neurosci] 2020 Nov; Vol. 23 (11), pp. 1339-1351. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyotrophic Lateral Sclerosis/*immunology
Axons/*immunology
Macrophages/*immunology
Microglia/*immunology
Motor Neurons/*immunology
Sciatic Nerve/*immunology
Adult ; Aged ; Amyotrophic Lateral Sclerosis/metabolism ; Animals ; Female ; Humans ; Macrophages/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia/metabolism ; Middle Aged ; Motor Neurons/metabolism ; Sciatic Nerve/metabolism ; Spinal Cord/immunology ; Spinal Cord/metabolism
Czasopismo naukowe
Tytuł :
Help from peripheral macrophages in ALS?
Autorzy :
Özdinler PH; Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. .
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Źródło :
Nature neuroscience [Nat Neurosci] 2020 Nov; Vol. 23 (11), pp. 1311-1312.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Amyotrophic Lateral Sclerosis*
Microglia*
Humans ; Macrophages
SCR Disease Name :
Amyotrophic Lateral Sclerosis 2, Juvenile
Czasopismo naukowe
Tytuł :
Brainwide Genetic Sparse Cell Labeling to Illuminate the Morphology of Neurons and Glia with Cre-Dependent MORF Mice.
Autorzy :
Veldman MB; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, and Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
Park CS; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, and Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
Eyermann CM; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, and Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
Zhang JY; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, and Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
Zuniga-Sanchez E; Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Hirano AA; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Veterans Administration of Greater Los Angeles Health System, Los Angeles, CA 90073, USA.
Daigle TL; Allen Institute for Brain Science, Seattle, WA 98109, USA.
Foster NN; Center for Integrative Connectomics, University of Southern California Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, USC, Los Angeles, CA, 90033, USA.
Zhu M; Center for Integrative Connectomics, University of Southern California Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, USC, Los Angeles, CA, 90033, USA.
Langfelder P; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, and Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
Lopez IA; Cellular and Molecular Biology of the Inner Ear Laboratory, Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Brecha NC; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Veterans Administration of Greater Los Angeles Health System, Los Angeles, CA 90073, USA; Departments of Medicine and Ophthalmology, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Zipursky SL; Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Zeng H; Allen Institute for Brain Science, Seattle, WA 98109, USA.
Dong HW; Center for Integrative Connectomics, University of Southern California Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, USC, Los Angeles, CA, 90033, USA; Zilkha Neurogenetic Institute, and Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Yang XW; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, and Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Oct 14; Vol. 108 (1), pp. 111-127.e6. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Astrocytes/*ultrastructure
Brain/*ultrastructure
Microglia/*ultrastructure
Neurons/*ultrastructure
Retinal Horizontal Cells/*ultrastructure
Animals ; Astrocytes/metabolism ; Astrocytes/pathology ; Brain/metabolism ; Brain/pathology ; Frameshift Mutation/genetics ; Green Fluorescent Proteins/genetics ; Integrases ; Mice ; Mice, Transgenic ; Microglia/metabolism ; Microglia/pathology ; Microsatellite Repeats/genetics ; Neurons/metabolism ; Neurons/pathology ; Retinal Horizontal Cells/metabolism ; Retinal Horizontal Cells/pathology
Czasopismo naukowe
Tytuł :
Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection.
Autorzy :
Sariol A; Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242.
Mackin S; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.
Allred MG; Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242.
Ma C; School of Mathematics and Statistics, Wuhan University, 430072 Wuhan, China.
Zhou Y; School of Mathematics and Statistics, Wuhan University, 430072 Wuhan, China.
Zhang Q; School of Mathematics and Statistics, Wuhan University, 430072 Wuhan, China.
Zou X; School of Mathematics and Statistics, Wuhan University, 430072 Wuhan, China.
Abrahante JE; University of Minnesota Informatics Institute (UMII), Minneapolis, MN 55455.
Meyerholz DK; Department of Pathology, University of Iowa, Iowa City, IA 52242.
Perlman S; Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242; .; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 29; Vol. 117 (39), pp. 24464-24474. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Remyelination*/genetics
Coronavirus Infections/*pathology
Demyelinating Diseases/*pathology
Microglia/*pathology
Animals ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Demyelinating Diseases/immunology ; Demyelinating Diseases/virology ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Immunity, Cellular/drug effects ; Inflammation ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/drug effects ; Microglia/metabolism ; Murine hepatitis virus/drug effects ; Murine hepatitis virus/physiology ; Myelin Sheath/metabolism ; Myelin Sheath/pathology ; Oligodendroglia/pathology ; Organic Chemicals/administration & dosage ; Organic Chemicals/adverse effects ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/antagonists & inhibitors ; Spinal Cord/immunology ; Spinal Cord/pathology
Czasopismo naukowe
Tytuł :
The AMPK pathway triggers autophagy during CSF1-induced microglial activation and may be implicated in inducing neuropathic pain.
Autorzy :
Yang G; Department of Orthopedic Surgery, The Hunan Children's Hospital, Changsha, Hunan Province, P.R. China; Post-Doctoral Mobile Research Station, Xiangya Hospital, Central South University, Changsha, Hunan Province, P.R. China.
Tan Q; Department of Orthopedic Surgery, The Hunan Children's Hospital, Changsha, Hunan Province, P.R. China.
Li Z; Department of Orthopedic Surgery, the First Hospital of Medical College of Zhejiang University, Hangzhou, Zhejiang Province, P.R. China.
Liu K; Department of Orthopedic Surgery, The Hunan Children's Hospital, Changsha, Hunan Province, P.R. China.
Wu J; Department of Orthopedic Surgery, The Hunan Children's Hospital, Changsha, Hunan Province, P.R. China.
Ye W; Department of Orthopedic Surgery, The Hunan Children's Hospital, Changsha, Hunan Province, P.R. China.
Mei H; Department of Orthopedic Surgery, The Hunan Children's Hospital, Changsha, Hunan Province, P.R. China. Electronic address: .
Yu H; Department of Orthopedic and Trauma Surgery, University Hospital Bonn, Germany. Electronic address: .
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Źródło :
Journal of neuroimmunology [J Neuroimmunol] 2020 Aug 15; Vol. 345, pp. 577261. Date of Electronic Publication: 2020 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
AMP-Activated Protein Kinases/*metabolism
Autophagy/*physiology
Macrophage Colony-Stimulating Factor/*administration & dosage
Microglia/*metabolism
Neuralgia/*chemically induced
Neuralgia/*metabolism
Animals ; Autophagy/drug effects ; Cells, Cultured ; Injections, Spinal ; Macrophage Colony-Stimulating Factor/toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia/drug effects ; Microglia/pathology ; Neuralgia/pathology ; Signal Transduction/drug effects ; Signal Transduction/physiology
Czasopismo naukowe

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