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Tytuł :
Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke.
Autorzy :
Zhang L; Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. Electronic address: .
Liu Y; Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. Electronic address: .
Wang S; Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. Electronic address: .
Long L; Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. Electronic address: .
Zang Q; Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. Electronic address: .
Ma J; Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 400010, China; Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, China. Electronic address: .
Yu L; Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. Electronic address: .
Jia G; Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Nov 05; Vol. 577, pp. 71-79. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ischemic Stroke/*physiopathology
Microglia/*physiology
Signal Transduction/*physiology
Toll-Like Receptor 4/*metabolism
Vagus Nerve Stimulation/*methods
Animals ; Brain Injuries/metabolism ; Brain Injuries/physiopathology ; Ischemic Stroke/metabolism ; Microglia/classification ; Microglia/metabolism ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/metabolism ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Roles of microglia in Alzheimer's disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention.
Autorzy :
Takata K; Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. Electronic address: .
Ginhoux F; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Translational Immunology Institute, SingHealth/Duke-NUS, Academic Medical Centre, The Academia, Singapore 169856, Singapore.
Shimohama S; Department of Neurology, Sapporo Medical University, School of Medicine, Sapporo 060-8543, Japan.
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Oct; Vol. 192, pp. 114754. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Alzheimer Disease/*drug therapy
Brain/*drug effects
Drug Delivery Systems/*methods
Microglia/*drug effects
Neuroprotective Agents/*administration & dosage
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Brain/metabolism ; Brain/pathology ; Humans ; Microglia/metabolism ; Microglia/pathology
Czasopismo naukowe
Tytuł :
Magnolol attenuates depressive-like behaviors by polarizing microglia towards the M2 phenotype through the regulation of Nrf2/HO-1/NLRP3 signaling pathway.
Autorzy :
Tao W; School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 220023, China.
Hu Y; Jiangsu Medical Device Testing Institute, Nanjing 220023, China.
Chen Z; School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Dai Y; School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Hu Y; School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: .
Qi M; School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Oct; Vol. 91, pp. 153692. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Microglia*/cytology
Microglia*/drug effects
Biphenyl Compounds/*pharmacology
Depression/*drug therapy
Lignans/*pharmacology
Signal Transduction/*drug effects
Animals ; Cell Polarity ; Heme Oxygenase-1 ; Lipopolysaccharides ; Membrane Proteins ; Mice ; NF-E2-Related Factor 2/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein
Czasopismo naukowe
Tytuł :
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Autorzy :
Lu Y; Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, 210001, China.
Hao R; Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, 210001, China.
Hu Y; Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, 210001, China.
Wei Y; Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, 210001, China.
Xie Y; Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, 210001, China.
Shen Y; Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, 210001, China.
Rui Q; Department of Emergency, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, 210001, China. Electronic address: .
Yu G; Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, 210001, China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Oct 01; Vol. 348, pp. 109653. Date of Electronic Publication: 2021 Sep 10.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin II/*pharmacology
Apoptosis/*drug effects
Blood-Brain Barrier/*metabolism
Iridoid Glycosides/*pharmacology
Microglia/*drug effects
Neurons/*drug effects
Pyrans/*pharmacology
Signal Transduction/*drug effects
Blood-Brain Barrier/drug effects ; Cell Line ; Humans ; Microglia/cytology ; Microglia/metabolism ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/metabolism ; Neurons/cytology ; Neurons/metabolism ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Control of Neuroinflammation through Radiation-Induced Microglial Changes.
Autorzy :
Boyd A; Australian Nuclear Science and Technology Organisation, Sydney, NSW 2234, Australia.
Byrne S; Australian Nuclear Science and Technology Organisation, Sydney, NSW 2234, Australia.
Middleton RJ; Australian Nuclear Science and Technology Organisation, Sydney, NSW 2234, Australia.
Banati RB; Australian Nuclear Science and Technology Organisation, Sydney, NSW 2234, Australia.; Discipline of Medical Imaging & Radiation Sciences, Faculty of Medicine and Health, Brain and Mind Centre, University of Sydney, Sydney, NSW 2050, Australia.
Liu GJ; Australian Nuclear Science and Technology Organisation, Sydney, NSW 2234, Australia.; Discipline of Medical Imaging & Radiation Sciences, Faculty of Medicine and Health, Brain and Mind Centre, University of Sydney, Sydney, NSW 2050, Australia.
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Źródło :
Cells [Cells] 2021 Sep 10; Vol. 10 (9). Date of Electronic Publication: 2021 Sep 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Inflammation Mediators/*metabolism
Microglia/*radiation effects
Neurodegenerative Diseases/*radiotherapy
Neuroimmunomodulation/*radiation effects
Reactive Nitrogen Species/*metabolism
Reactive Oxygen Species/*metabolism
Animals ; Dose-Response Relationship, Radiation ; Humans ; Immunity, Innate/radiation effects ; Microglia/immunology ; Microglia/metabolism ; Microglia/pathology ; Neurodegenerative Diseases/immunology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Nitrosative Stress/radiation effects ; Oxidative Stress/radiation effects ; Phenotype ; Receptors, GABA/metabolism
Czasopismo naukowe
Tytuł :
The CSF1R-Microglia Axis Has Protective Host-Specific Roles During Neurotropic Picornavirus Infection.
Autorzy :
Sanchez JMS; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States.
DePaula-Silva AB; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Doty DJ; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Hanak TJ; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Truong A; Department of Oncological Sciences, Huntsman Cancer Institute, Salt Lake City, UT, United States.
Libbey JE; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Fujinami RS; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Sep 09; Vol. 12, pp. 621090. Date of Electronic Publication: 2021 Sep 09 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cardiovirus Infections/*immunology
Microglia/*immunology
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/*immunology
Animals ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/drug effects ; Microglia/metabolism ; Organic Chemicals/pharmacology ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Theilovirus/immunology
Czasopismo naukowe
Tytuł :
Long-term cognitive deficits after traumatic brain injury associated with microglia activation.
Autorzy :
Saba ES; Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut, Lebanon.
Karout M; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut Medical Center, Lebanon.
Nasrallah L; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut Medical Center, Lebanon.
Kobeissy F; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut Medical Center, Lebanon.
Darwish H; Nehme and Therese Tohme Multiple Sclerosis Center, Faculty of Medicine, American University of Beirut Medical Center, Lebanon; Hariri School of Nursing, American University of Beirut, Lebanon. Electronic address: .
Khoury SJ; Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut, Lebanon; Nehme and Therese Tohme Multiple Sclerosis Center, Faculty of Medicine, American University of Beirut Medical Center, Lebanon. Electronic address: .
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2021 Sep; Vol. 230, pp. 108815. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Brain Injuries, Traumatic/*complications
Cognitive Dysfunction/*etiology
Microglia/*physiology
Animals ; Brain/pathology ; Brain/physiopathology ; Brain Injuries, Traumatic/pathology ; Brain Injuries, Traumatic/psychology ; Cognitive Dysfunction/pathology ; Cognitive Dysfunction/psychology ; Disease Models, Animal ; Flow Cytometry ; Male ; Maze Learning/physiology ; Mice ; Mice, Inbred C57BL ; Microglia/classification ; Microglia/pathology ; Models, Neurological ; Models, Psychological ; Nonlinear Dynamics ; Spatial Learning/physiology ; Spatial Memory/physiology ; Spatio-Temporal Analysis ; Translational Medical Research
Czasopismo naukowe
Tytuł :
IL-33/ST2 Signaling Regulates Synaptic Plasticity and Homeostasis in the Adult Hippocampal Circuitry.
Autorzy :
Wang Y; Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
Fu AKY; Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, China.
Ip NY; Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, China.
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Źródło :
DNA and cell biology [DNA Cell Biol] 2021 Sep; Vol. 40 (9), pp. 1125-1130. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neuronal Plasticity*
Alzheimer Disease/*metabolism
Astrocytes/*metabolism
Interleukin-33/*physiology
Microglia/*metabolism
Adult ; Animals ; Astrocytes/cytology ; Astrocytes/pathology ; Hippocampus/metabolism ; Humans ; Mice ; Microglia/cytology ; Microglia/pathology ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
The microglial lysosomal system in Alzheimer's disease: Guardian against proteinopathy.
Autorzy :
Van Acker ZP; VIB Center for Brain & Disease Research, Laboratory for Membrane Trafficking, 3000, Leuven, Belgium; KU Leuven, Department of Neurosciences, 3000, Leuven, Belgium. Electronic address: .
Perdok A; VIB Center for Brain & Disease Research, Laboratory for Membrane Trafficking, 3000, Leuven, Belgium; KU Leuven, Department of Neurosciences, 3000, Leuven, Belgium. Electronic address: .
Bretou M; VIB Center for Brain & Disease Research, Laboratory for Membrane Trafficking, 3000, Leuven, Belgium; KU Leuven, Department of Neurosciences, 3000, Leuven, Belgium. Electronic address: .
Annaert W; VIB Center for Brain & Disease Research, Laboratory for Membrane Trafficking, 3000, Leuven, Belgium; KU Leuven, Department of Neurosciences, 3000, Leuven, Belgium. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 Nov; Vol. 71, pp. 101444. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Alzheimer Disease*/genetics
Microglia*
Humans ; Lysosomes ; Phagocytosis
Czasopismo naukowe
Tytuł :
Sharing is caring: The benefits of distributing protein aggregates among microglial networks.
Autorzy :
Wiersma VI; Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Polymenidou M; Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address: .
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Źródło :
Neuron [Neuron] 2021 Oct 20; Vol. 109 (20), pp. 3228-3230.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Microglia*
Neurodegenerative Diseases*
Humans ; Protein Aggregates ; alpha-Synuclein
Czasopismo naukowe
Tytuł :
The role of NLRP3 in lead-induced neuroinflammation and possible underlying mechanism.
Autorzy :
Su P; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: .
Wang D; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: .
Cao Z; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: .
Chen J; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: .
Zhang J; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: .
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Źródło :
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2021 Oct 15; Vol. 287, pp. 117520. Date of Electronic Publication: 2021 Jun 15.
Typ publikacji :
Journal Article
MeSH Terms :
Microglia*
NLR Family, Pyrin Domain-Containing 3 Protein*/genetics
Animals ; Cytokines ; Inflammasomes ; Mice ; NF-kappa B
Czasopismo naukowe
Tytuł :
Depression-like behavior associated with E/I imbalance of mPFC and amygdala without TRPC channels in mice of knockout IL-10 from microglia.
Autorzy :
Yang L; Medical School, Nankai University, Tianjin, China.
Liu C; Medical School, Nankai University, Tianjin, China.
Li W; The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases; Artificial Cell Engineering Technology Research Center, Tianjin, China; Tianjin Institute of Hepatobiliary Disease, Tianjin, China.
Ma Y; Medical School, Nankai University, Tianjin, China; Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Tianjin, China.
Huo S; Medical School, Nankai University, Tianjin, China; Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Tianjin, China.
Ozathaley A; Medical School, Nankai University, Tianjin, China.
Ren J; Department of Pathogen Biology, Basic Medical School, Tianjin Medical University, Tianjin, China.
Yuan W; Medical School, Nankai University, Tianjin, China; Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Tianjin, China.
Ni H; Medical School, Nankai University, Tianjin, China.
Li D; Medical School, Nankai University, Tianjin, China.
Zhang J; The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases; Artificial Cell Engineering Technology Research Center, Tianjin, China; Tianjin Institute of Hepatobiliary Disease, Tianjin, China. Electronic address: .
Liu Z; Medical School, Nankai University, Tianjin, China; Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Tianjin, China. Electronic address: .
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2021 Oct; Vol. 97, pp. 68-78. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Depression*
Microglia*
TRPC Cation Channels/*genetics
Amygdala ; Animals ; Interleukin-10/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Prefrontal Cortex
Czasopismo naukowe
Tytuł :
Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice.
Autorzy :
Picard K; Axe neurosciences, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada; Molecular Medicine Department, Université Laval, Québec City, QC, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.
Bisht K; Axe neurosciences, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Poggini S; Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Garofalo S; Department of Physiology and Pharmacology, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy.
Golia MT; Department of Physiology and Pharmacology, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy.
Basilico B; Department of Physiology and Pharmacology, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy; Institute of Science and Technology (IST) Austria, Klosterneuburg, Austria.
Abdallah F; Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Ciano Albanese N; Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy; Institute of Science and Technology (IST) Austria, Klosterneuburg, Austria.
Amrein I; Functional Neuroanatomy, Institute of Anatomy, University of Zürich, Zurich, Switzerland.
Vernoux N; Axe neurosciences, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Sharma K; Axe neurosciences, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Hui CW; Axe neurosciences, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
C Savage J; Axe neurosciences, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Limatola C; Department of Physiology and Pharmacology, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy; IRCCS Neuromed, Pozzilli, Italy.
Ragozzino D; Department of Physiology and Pharmacology, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy.
Maggi L; Department of Physiology and Pharmacology, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy.
Branchi I; Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Tremblay MÈ; Axe neurosciences, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada; Molecular Medicine Department, Université Laval, Québec City, QC, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada; The Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, Canada. Electronic address: .
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2021 Oct; Vol. 97, pp. 423-439. Date of Electronic Publication: 2021 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Microglia*/metabolism
Receptors, Glucocorticoid*/genetics
Receptors, Glucocorticoid*/metabolism
Animals ; Female ; Hippocampus/metabolism ; Male ; Membrane Glycoproteins ; Mice ; Neurogenesis ; Neurons/metabolism ; Receptors, Immunologic ; Stress, Psychological
Czasopismo naukowe
Tytuł :
Thalidomide alleviates neuropathic pain through microglial IL-10/β-endorphin signaling pathway.
Autorzy :
Deng MY; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai 200240, China.
Ahmad KA; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai 200240, China.
Han QQ; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai 200240, China.
Wang ZY; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai 200240, China.
Shoaib RM; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai 200240, China.
Li XY; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai 200240, China. Electronic address: .
Wang YX; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai 200240, China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Oct; Vol. 192, pp. 114727. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-10/*biosynthesis
Microglia/*metabolism
Neuralgia/*drug therapy
Neuralgia/*metabolism
Thalidomide/*therapeutic use
beta-Endorphin/*biosynthesis
Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Interleukin-10/agonists ; Male ; Microglia/drug effects ; Rats ; Rats, Wistar ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Thalidomide/pharmacology ; beta-Endorphin/agonists
Czasopismo naukowe
Tytuł :
Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and dentate gyrus, resulting in cognitive inflexibility during late adolescence.
Autorzy :
Fernández de Cossío L; Department of Neurosciences, University of California, La Jolla, CA, USA; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada. Electronic address: .
Lacabanne C; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada.
Bordeleau M; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Axe Neurosciences, Centre de Recherche du CHU de Québec - Université Laval, Québec, QC, Canada.
Castino G; Department of Biology, École Normale Supérieure de Lyon, Université de Lyon, Lyon, France.
Kyriakakis P; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Tremblay MÈ; Axe Neurosciences, Centre de Recherche du CHU de Québec - Université Laval, Québec, QC, Canada; Département de médecine moléculaire, Université Laval, Québec, QC, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada; Biochemistry and Molecular Biology, Faculty of Medicine, The University of British Colombia, Vancouver, BC, Canada. Electronic address: .
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2021 Oct; Vol. 97, pp. 440-454. Date of Electronic Publication: 2021 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autism Spectrum Disorder*
Microglia*/metabolism
CX3C Chemokine Receptor 1/*genetics
Adolescent ; CX3C Chemokine Receptor 1/metabolism ; Cognition ; Dentate Gyrus/metabolism ; Female ; Hippocampus/metabolism ; Humans ; Lipopolysaccharides ; Male ; Phenotype ; Pregnancy
Czasopismo naukowe
Tytuł :
Geranylgeraniol Inhibits Lipopolysaccharide-Induced Inflammation in Mouse-Derived MG6 Microglial Cells via NF-κB Signaling Modulation.
Autorzy :
Saputra WD; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Shono H; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Ohsaki Y; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.; International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Sultana H; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Komai M; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Shirakawa H; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.; International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 29; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Diterpenes/*pharmacology
Inflammation/*prevention & control
Microglia/*drug effects
NF-kappa B/*metabolism
Signal Transduction/*drug effects
Active Transport, Cell Nucleus/drug effects ; Animals ; Blotting, Western ; Cell Line ; Cytokines/genetics ; Cytokines/metabolism ; Gene Expression/drug effects ; Inflammation/chemically induced ; Lipopolysaccharides ; Mice ; Microglia/cytology ; Microglia/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Transcription Factor RelA/metabolism
Czasopismo naukowe
Tytuł :
Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury.
Autorzy :
Kyyriäinen J; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.
Kajevu N; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.
Bañuelos I; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.
Lara L; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.
Lipponen A; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.; Department of Health Security, Finnish Institute for Health and Welfare, FI-70701 Kuopio, Finland.
Balosso S; Department of Neuroscience, Mario Negri Institute for Pharmacological Research IRCCS, 20156 Milano, Italy.
Hämäläinen E; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.
Das Gupta S; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.
Puhakka N; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.
Natunen T; Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
Ravizza T; Department of Neuroscience, Mario Negri Institute for Pharmacological Research IRCCS, 20156 Milano, Italy.
Vezzani A; Department of Neuroscience, Mario Negri Institute for Pharmacological Research IRCCS, 20156 Milano, Italy.
Hiltunen M; Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
Pitkänen A; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 29; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcysteine/*pharmacology
Brain Injuries, Traumatic/*drug therapy
Isothiocyanates/*pharmacology
Microglia/*drug effects
Neurons/*drug effects
Oxidative Stress/*drug effects
Sulfoxides/*pharmacology
Animals ; Antioxidants/pharmacology ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Brain Injuries, Traumatic/genetics ; Brain Injuries, Traumatic/metabolism ; Cell Line ; Cell Survival/drug effects ; Cells, Cultured ; Disease Models, Animal ; Gene Expression/drug effects ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Male ; Mice, Inbred C57BL ; Microglia/cytology ; Microglia/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Neurons/cytology ; Neurons/metabolism ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways.
Autorzy :
Tsay HJ; Institute of Neuroscience, School of Life Science, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
Liu HK; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan.; Program in Clinical Drug Development of Chinese Medicine, Taipei Medical University, Taipei 112, Taiwan.
Kuo YH; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan.; Department of Biotechnology, Asia University, Taichung 413, Taiwan.; Chinese Medicine Research Center, China Medical University, Taichung 404, Taiwan.
Chiu CS; Institute of Biopharmaceutical Science, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
Liang CC; Institute of Anatomy and Cell Biology, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
Chung CW; Institute of Traditional Medicine, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
Chen CC; Biotech Research Institute, Grape King Bio Ltd., Taoyuan City 320, Taiwan.
Chen YP; Biotech Research Institute, Grape King Bio Ltd., Taoyuan City 320, Taiwan.
Shiao YJ; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan.; Program in Clinical Drug Development of Chinese Medicine, Taipei Medical University, Taipei 112, Taiwan.; Institute of Biopharmaceutical Science, National Yang-Ming Chiao Tung University, Taipei 112, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 27; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/drug therapy
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Maleimides*/chemistry
Maleimides*/pharmacology
Plaque, Amyloid*/drug therapy
Plaque, Amyloid*/genetics
Plaque, Amyloid*/metabolism
Amyloid beta-Protein Precursor/*metabolism
Microglia/*metabolism
Polyporales/*chemistry
Presenilin-1/*metabolism
Amyloid beta-Protein Precursor/genetics ; Animals ; Cell Line ; Mice ; Mice, Transgenic ; Microglia/pathology ; Presenilin-1/genetics
SCR Organism :
Taiwanofungus camphoratus
Czasopismo naukowe
Tytuł :
LED-Induced Microglial Activation and Rise in Caspase3 Suggest a Reorganization in the Retina.
Autorzy :
Balogh B; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.; Retinal Electrical Synapses Research Group, National Brain Research Program (NAP 2.0), Hungarian Academy of Sciences, 1051 Budapest, Hungary.; Institute of Biology, Faculty of Sciences, University of Pécs, 7624 Pécs, Hungary.
Szarka G; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.; Retinal Electrical Synapses Research Group, National Brain Research Program (NAP 2.0), Hungarian Academy of Sciences, 1051 Budapest, Hungary.; Institute of Biology, Faculty of Sciences, University of Pécs, 7624 Pécs, Hungary.
Tengölics ÁJ; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.; Retinal Electrical Synapses Research Group, National Brain Research Program (NAP 2.0), Hungarian Academy of Sciences, 1051 Budapest, Hungary.; Institute of Biology, Faculty of Sciences, University of Pécs, 7624 Pécs, Hungary.
Hoffmann G; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.; Retinal Electrical Synapses Research Group, National Brain Research Program (NAP 2.0), Hungarian Academy of Sciences, 1051 Budapest, Hungary.; Institute of Biology, Faculty of Sciences, University of Pécs, 7624 Pécs, Hungary.
Völgyi B; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.; Retinal Electrical Synapses Research Group, National Brain Research Program (NAP 2.0), Hungarian Academy of Sciences, 1051 Budapest, Hungary.; Institute of Biology, Faculty of Sciences, University of Pécs, 7624 Pécs, Hungary.; Medical School, University of Pécs, 7624 Pécs, Hungary.
Kovács-Öller T; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.; Retinal Electrical Synapses Research Group, National Brain Research Program (NAP 2.0), Hungarian Academy of Sciences, 1051 Budapest, Hungary.; Institute of Biology, Faculty of Sciences, University of Pécs, 7624 Pécs, Hungary.; Medical School, University of Pécs, 7624 Pécs, Hungary.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 27; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Caspase 3/*metabolism
Light/*adverse effects
Microglia/*metabolism
Retina/*metabolism
Retinal Degeneration/*metabolism
Animals ; Humans ; Mice ; Microglia/pathology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Retina/pathology ; Retinal Degeneration/pathology ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
A Subpopulation of Microglia Generated in the Adult Mouse Brain Originates from Prominin-1-Expressing Progenitors.
Autorzy :
Prater KE; Departments of Neurology and.
Aloi MS; Departments of Neurology and.; Pathology, University of Washington, Seattle, Washington 98195.
Pathan JL; Departments of Neurology and.
Winston CN; Departments of Neurology and.
Chernoff RA; Departments of Neurology and.
Davidson S; Departments of Neurology and.
Sadgrove M; Department of Neurology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599.
McDonough A; Departments of Neurology and.
Zierath D; Departments of Neurology and.
Su W; Departments of Neurology and.
Weinstein JR; Departments of Neurology and.; Center on Human Development and Disability, University of Washington, Seattle, Washington 98195.
Garden GA; Departments of Neurology and .; Pathology, University of Washington, Seattle, Washington 98195.; Center on Human Development and Disability, University of Washington, Seattle, Washington 98195.; Department of Neurology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Sep 22; Vol. 41 (38), pp. 7942-7953. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
AC133 Antigen/*metabolism
Brain/*cytology
Cell Differentiation/*physiology
Microglia/*cytology
Animals ; Brain/metabolism ; Cell Proliferation/physiology ; Female ; Male ; Mice ; Microglia/metabolism
Czasopismo naukowe

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