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Wyszukujesz frazę ""mitochondria"" wg kryterium: Temat


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Tytuł :
Mitochondria-targeted prooxidant effects of betulinic acid conjugated with delocalized lipophilic cation F16.
Autorzy :
Dubinin MV; Mari State University, Pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia. Electronic address: .
Semenova AA; Mari State University, Pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia.
Ilzorkina AI; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, Pushchino, Moscow Region, 142290, Russia.
Penkov NV; Institute of Cell Biophysics, Russian Academy of Sciences, PSCBR RAS, Institutskaya 3, Pushchino, Moscow Region, 142290, Russia.
Nedopekina DA; Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, Prospekt Oktyabrya 141, Ufa, Republic of Bashkortostan, 450075, Russia.
Sharapov VA; Mari State University, Pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia.
Khoroshavina EI; Mari State University, Pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia.
Davletshin EV; Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, Prospekt Oktyabrya 141, Ufa, Republic of Bashkortostan, 450075, Russia.
Belosludtseva NV; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, Pushchino, Moscow Region, 142290, Russia.
Spivak AY; Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, Prospekt Oktyabrya 141, Ufa, Republic of Bashkortostan, 450075, Russia.
Belosludtsev KN; Mari State University, Pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, Pushchino, Moscow Region, 142290, Russia; Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilova 38, Moscow, 119991, Russia.
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2021 May 20; Vol. 168, pp. 55-69. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondria*
Triterpenes*/metabolism
Animals ; Cations/metabolism ; Mitochondria, Liver/metabolism ; Pentacyclic Triterpenes ; Rats ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Mitochondria-associated membrane-modulated Ca transfer: A potential treatment target in cardiac ischemia reperfusion injury and heart failure.
Autorzy :
Gong Y; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, China.
Lin J; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, China.
Ma Z; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, China.
Yu M; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, China.
Wang M; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, China. Electronic address: .
Lai D; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, China. Electronic address: .
Fu G; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119511. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Calcium/*metabolism
Heart Failure/*metabolism
Mitochondria/*metabolism
Myocardial Ischemia/*metabolism
Reperfusion Injury/*metabolism
Animals ; Calcium Signaling ; Cell Line ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Homeostasis ; Humans ; Mice ; Mitochondria, Heart/metabolism ; Mitochondrial Membranes/metabolism ; Myocardial Contraction ; Myocardial Reperfusion Injury/metabolism ; Myocytes, Cardiac/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Effects of anticancer drugs on the cardiac mitochondrial toxicity and their underlying mechanisms for novel cardiac protective strategies.
Autorzy :
Kim CW; Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.
Choi KC; Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jul 15; Vol. 277, pp. 119607. Date of Electronic Publication: 2021 May 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*adverse effects
Mitochondria, Heart/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Arsenic Trioxide/pharmacology ; Cardiotoxicity/metabolism ; Cardiovascular System/drug effects ; Doxorubicin/pharmacology ; Endoplasmic Reticulum Stress/drug effects ; Heart Diseases/metabolism ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria, Heart/drug effects ; Myocytes, Cardiac/drug effects ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Exercise and mitochondrial health.
Autorzy :
Memme JM; Muscle Health Research Centre, York University, Toronto, Ontario, Canada, M3J 1P3.; School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada, M3J 1P3.
Erlich AT; Muscle Health Research Centre, York University, Toronto, Ontario, Canada, M3J 1P3.; School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada, M3J 1P3.
Phukan G; Muscle Health Research Centre, York University, Toronto, Ontario, Canada, M3J 1P3.; School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada, M3J 1P3.
Hood DA; Muscle Health Research Centre, York University, Toronto, Ontario, Canada, M3J 1P3.; School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada, M3J 1P3.
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Źródło :
The Journal of physiology [J Physiol] 2021 Feb; Vol. 599 (3), pp. 803-817. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Exercise*
Mitochondria, Muscle*/metabolism
Humans ; Mitochondria ; Mitophagy ; Muscle, Skeletal/metabolism ; Organelle Biogenesis
Czasopismo naukowe
Tytuł :
Low abundance of Mfn2 protein correlates with reduced mitochondria-SR juxtaposition and mitochondrial cristae density in human men skeletal muscle: Examining organelle measurements from TEM images.
Autorzy :
Castro-Sepulveda M; Escuela de Kinesiología, Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile.; Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Fernández-Verdejo R; Carrera de Nutrición y Dietética, Departamento de Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Tuñón-Suárez M; Escuela de Kinesiología, Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile.
Morales-Zúñiga J; Laboratorio de Ciencias del Deporte, Clínica Sports Medicina Deportiva, Viña del Mar, Chile.
Troncoso M; Faculty of Chemical and Pharmaceutical Science & Faculty of Medicine, Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile, Santiago, Chile.
Jannas-Vela S; Escuela de Kinesiología, Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile.
Zbinden-Foncea H; Escuela de Kinesiología, Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile.; Centro de Salud Deportiva, Clinica Santa Maria, Santiago, Chile.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Apr; Vol. 35 (4), pp. e21553.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
GTP Phosphohydrolases/*metabolism
Mitochondria/*metabolism
Mitochondrial Membranes/*metabolism
Mitochondrial Proteins/*metabolism
Muscle, Skeletal/*metabolism
Calcium/metabolism ; Humans ; Mitochondria/ultrastructure ; Mitochondria, Muscle/metabolism ; Mitochondrial Membranes/ultrastructure ; Muscle, Skeletal/ultrastructure ; Sarcoplasmic Reticulum/metabolism
Czasopismo naukowe
Tytuł :
At the heart of mitochondrial quality control: many roads to the top.
Autorzy :
Gottlieb RA; Smidt Heart Institute, Cedars-Sinai Medical Center, AHSP9313, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA. .
Piplani H; Smidt Heart Institute, Cedars-Sinai Medical Center, AHSP9313, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Sin J; Smidt Heart Institute, Cedars-Sinai Medical Center, AHSP9313, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Sawaged S; Smidt Heart Institute, Cedars-Sinai Medical Center, AHSP9313, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Hamid SM; Smidt Heart Institute, Cedars-Sinai Medical Center, AHSP9313, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Taylor DJ; Smidt Heart Institute, Cedars-Sinai Medical Center, AHSP9313, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
de Freitas Germano J; Smidt Heart Institute, Cedars-Sinai Medical Center, AHSP9313, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Apr; Vol. 78 (8), pp. 3791-3801. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Mitochondrial Dynamics*
Mitophagy*
Mitochondria/*metabolism
Animals ; DNA, Mitochondrial/metabolism ; Humans ; Mitochondria, Heart/metabolism ; Mitochondrial Proteins/metabolism ; Unfolded Protein Response
Czasopismo naukowe
Tytuł :
Simultaneous Quantification of Mitochondrial ATP and ROS Production Using ATP Energy Clamp Methodology.
Autorzy :
Yu L; Division of Endocrinology and Metabolism, Department of Internal Medicine, The University of Iowa, Iowa City, IA, USA.
Fink BD; Division of Endocrinology and Metabolism, Department of Internal Medicine, The University of Iowa, Iowa City, IA, USA.
Sivitz WI; Division of Endocrinology and Metabolism, Department of Internal Medicine, The University of Iowa, Iowa City, IA, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2276, pp. 271-283.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adenosine Triphosphate/*metabolism
Hydrogen Peroxide/*metabolism
Magnetic Resonance Spectroscopy/*methods
Mitochondria/*metabolism
Reactive Oxygen Species/*metabolism
Animals ; Deoxyglucose/metabolism ; Energy Metabolism ; Hexokinase/metabolism ; Membrane Potential, Mitochondrial ; Mice ; Mitochondria, Heart/metabolism ; Mitochondria, Liver/metabolism ; Mitochondrial Proton-Translocating ATPases/metabolism
Czasopismo naukowe
Tytuł :
Isolation and Quality Control of Functional Mitochondria.
Autorzy :
Hartwig S; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Kotzka J; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Lehr S; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany. .; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2276, pp. 41-55.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Fractionation/*methods
Centrifugation, Density Gradient/*methods
Centrifugation, Isopycnic/*methods
Microscopy, Electron/*methods
Mitochondria/*chemistry
Mitochondria/*metabolism
Animals ; Humans ; Liver/ultrastructure ; Mice ; Mitochondria/ultrastructure ; Mitochondria, Liver/chemistry ; Quality Control
Czasopismo naukowe
Tytuł :
Mitochondria and Calcium Homeostasis: Cisd2 as a Big Player in Cardiac Ageing.
Autorzy :
Yeh CH; Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Linko 333, Taiwan.; College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung Branch, Keelung 204, Taiwan.
Chou YJ; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan 350, Taiwan.
Kao CH; Center of General Education, Chang Gung University, Taoyuan 333, Taiwan.
Tsai TF; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan 350, Taiwan.; Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan.; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 350, Taiwan.; Aging and Health Research Center, National Yang-Ming University, Taipei 112, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 03; Vol. 21 (23). Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Homeostasis*
Calcium/*metabolism
Mitochondria, Heart/*metabolism
Animals ; Biomarkers ; Calcium Signaling ; Cellular Reprogramming ; Cellular Senescence/genetics ; Energy Metabolism ; Humans ; Intracellular Space/metabolism ; Lysosomes/metabolism ; Membrane Proteins/deficiency ; Membrane Proteins/metabolism ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Myocardium/metabolism ; Myocardium/ultrastructure ; Signal Transduction
Czasopismo naukowe
Tytuł :
MicroRNA-204-5p modulates mitochondrial biogenesis in C2C12 myotubes and associates with oxidative capacity in humans.
Autorzy :
Houzelle A; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Dahlmans D; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Nascimento EBM; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Schaart G; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Jörgensen JA; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Moonen-Kornips E; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Kersten S; Division of Human Nutrition, Nutrition, Metabolism and Genomics Group, Wageningen University, Wageningen, The Netherlands.
Wang X; Joint Center for Single Cell Biology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.; Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Hoeks J; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2020 Dec; Vol. 235 (12), pp. 9851-9863. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MicroRNAs/*genetics
Mitochondria/*genetics
Muscle Fibers, Skeletal/*metabolism
Muscle, Skeletal/*metabolism
Animals ; Autophagy/genetics ; Biopsy ; Humans ; Mice ; Mitochondria, Muscle/genetics ; Mitochondria, Muscle/metabolism ; Mitophagy/genetics ; Organelle Biogenesis ; Oxidation-Reduction ; Oxidative Stress/genetics
Czasopismo naukowe
Tytuł :
An integrative approach to the regulation of mitochondrial respiration during exercise: Focus on high-intensity exercise.
Autorzy :
Calbet JAL; Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017, Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe 'Físico' (s/n), 35017, Las Palmas de Gran Canaria, Canary Islands, Spain; Department of Physical Performance, The Norwegian School of Sport Sciences, Postboks, 4014 Ulleval Stadion, 0806 Oslo, Norway. Electronic address: .
Martín-Rodríguez S; Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017, Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe 'Físico' (s/n), 35017, Las Palmas de Gran Canaria, Canary Islands, Spain.
Martin-Rincon M; Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017, Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe 'Físico' (s/n), 35017, Las Palmas de Gran Canaria, Canary Islands, Spain.
Morales-Alamo D; Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017, Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe 'Físico' (s/n), 35017, Las Palmas de Gran Canaria, Canary Islands, Spain.
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Źródło :
Redox biology [Redox Biol] 2020 Aug; Vol. 35, pp. 101478. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Exercise*
Mitochondria, Muscle*/metabolism
Female ; Humans ; Male ; Mitochondria/metabolism ; Muscle, Skeletal/metabolism ; Oxygen Consumption ; Respiration
Czasopismo naukowe
Tytuł :
Mechanical Permeabilization as a New Method for Assessment of Mitochondrial Function in Insect Tissues.
Autorzy :
Gaviraghi A; Federal University of Rio de Janeiro, Institute of Medical Biochemistry Leopoldo de Meis, Rio De Janeiro, RJ, Brazil.
Aveiro Y; Federal University of Rio de Janeiro, Institute of Medical Biochemistry Leopoldo de Meis, Rio De Janeiro, RJ, Brazil.
Carvalho SS; Federal University of Rio de Janeiro, Institute of Medical Biochemistry Leopoldo de Meis, Rio De Janeiro, RJ, Brazil.
Rosa RS; Federal University of Rio de Janeiro, Institute of Medical Biochemistry Leopoldo de Meis, Rio De Janeiro, RJ, Brazil.
Oliveira MP; Federal University of Rio de Janeiro, Institute of Medical Biochemistry Leopoldo de Meis, Rio De Janeiro, RJ, Brazil.
Oliveira MF; Federal University of Rio de Janeiro, Institute of Medical Biochemistry Leopoldo de Meis, Rio De Janeiro, RJ, Brazil. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2276, pp. 67-85.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aedes/*physiology
Drosophila/*physiology
Mitochondria/*physiology
Aedes/ultrastructure ; Animals ; Cell Respiration/physiology ; Drosophila/ultrastructure ; Mitochondria, Muscle/physiology ; Oxygen Consumption/physiology ; Permeability
Czasopismo naukowe
Tytuł :
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.
Autorzy :
Reynolds JC; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Lai RW; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Woodhead JST; Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.
Joly JH; USC Mork Family Department of Chemical Engineering and Materials Science, Los Angeles, CA, 90089, USA.
Mitchell CJ; Liggins Institute, The University of Auckland, Auckland, New Zealand.; School of Kinesiology, University of British Colombia, Vancouver, BC, Canada, V6T 1Z3.
Cameron-Smith D; Liggins Institute, The University of Auckland, Auckland, New Zealand.
Lu R; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Cohen P; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.; USC Norris Comprehensive Cancer Center, Los Angeles, CA, 90089, USA.
Graham NA; USC Mork Family Department of Chemical Engineering and Materials Science, Los Angeles, CA, 90089, USA.; USC Norris Comprehensive Cancer Center, Los Angeles, CA, 90089, USA.
Benayoun BA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.; USC Norris Comprehensive Cancer Center, Los Angeles, CA, 90089, USA.; USC Stem Cell Initiative, Los Angeles, CA, 90089, USA.
Merry TL; Liggins Institute, The University of Auckland, Auckland, New Zealand.; School of Kinesiology, University of British Colombia, Vancouver, BC, Canada, V6T 1Z3.
Lee C; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA. .; USC Norris Comprehensive Cancer Center, Los Angeles, CA, 90089, USA. .; Biomedical Science, Graduate School, Ajou University, Suwon, 16499, Korea. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 20; Vol. 12 (1), pp. 470. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*genetics
Homeostasis/*physiology
Mitochondria/*metabolism
Mitochondrial Proteins/*genetics
Mitochondrial Proteins/*metabolism
Muscle, Skeletal/*metabolism
Adult ; Animals ; Cell Line ; Cell Nucleus ; Gene Expression Regulation ; Humans ; Male ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Mitochondria, Muscle/metabolism ; Myoblasts/metabolism ; Stress, Physiological ; Young Adult
Czasopismo naukowe
Tytuł :
Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis.
Autorzy :
Sakai S; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.; Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Watanabe S; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.; Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Komine O; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.; Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Sobue A; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.; Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Medical Interactive Research and Academia Industry Collaboration Center, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Yamanaka K; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.; Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, Japan.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Jul; Vol. 35 (7), pp. e21688.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Amyotrophic Lateral Sclerosis/*pathology
Mitochondria/*pathology
Mitochondrial Membranes/*pathology
Mitochondrial Proteins/*metabolism
Neuroblastoma/*pathology
Amyotrophic Lateral Sclerosis/etiology ; Amyotrophic Lateral Sclerosis/metabolism ; Animals ; Humans ; Mice ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Mitochondrial Proteins/genetics ; Neuroblastoma/genetics ; Neuroblastoma/metabolism
Czasopismo naukowe
Tytuł :
TAT-Conjugated NDUFS8 Can Be Transduced into Mitochondria in a Membrane-Potential-Independent Manner and Rescue Complex I Deficiency.
Autorzy :
Lin BY; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
Zheng GT; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
Teng KW; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
Chang JY; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
Lee CC; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
Liao PC; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
Kao MC; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.; Department of Life Science, College of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 17; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Membrane Potential, Mitochondrial*
Electron Transport Complex I/*deficiency
Mitochondria/*genetics
Mitochondria/*metabolism
NADH Dehydrogenase/*metabolism
Recombinant Fusion Proteins/*metabolism
tat Gene Products, Human Immunodeficiency Virus/*metabolism
Amino Acid Sequence ; Cell Line ; Cell Survival ; Cells, Cultured ; Electron Transport Chain Complex Proteins/genetics ; Electron Transport Chain Complex Proteins/metabolism ; Humans ; Mitochondria/drug effects ; NADH Dehydrogenase/genetics ; Protein Transport ; RNA Interference ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/pharmacology ; tat Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway.
Autorzy :
Liu L; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Cao Q; Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Gao W; Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Li B; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Xia Z; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Zhao B; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
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Źródło :
Aging [Aging (Albany NY)] 2021 Jun 11; Vol. 13 (12), pp. 16105-16123. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Ischemia/*drug therapy
Diabetes Mellitus, Experimental/*drug therapy
Melatonin/*therapeutic use
Mitochondria/*pathology
Proto-Oncogene Proteins c-akt/*metabolism
Reperfusion Injury/*drug therapy
Sirtuin 3/*metabolism
Superoxide Dismutase/*metabolism
Animals ; Apoptosis/drug effects ; Brain Edema/complications ; Brain Edema/drug therapy ; Brain Edema/pathology ; Brain Ischemia/complications ; Cell Line ; Cell Survival/drug effects ; Chromones/pharmacology ; Diabetes Mellitus, Experimental/complications ; Glucose/toxicity ; Male ; Melatonin/pharmacology ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/ultrastructure ; Morpholines/pharmacology ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Oxidative Stress/drug effects ; Reperfusion Injury/complications ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
A PI polyamide-TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation.
Autorzy :
Koshikawa N; Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan.
Yasui N; Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan.
Kida Y; Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan.
Shinozaki Y; Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan.; Organometallchemie Eduard-Zintl-Institut Technische Universität Darmstadt, Darmstadt, Germany.
Tsuji K; Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan.
Watanabe T; Division of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan.
Takenaga K; Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan.
Nagase H; Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Jun; Vol. 112 (6), pp. 2504-2512. Date of Electronic Publication: 2021 May 02.
Typ publikacji :
Journal Article
MeSH Terms :
DNA, Mitochondrial/*drug effects
Imidazoles/*pharmacology
Mitochondria/*genetics
Neoplasms/*genetics
Pyrroles/*chemistry
Sulfonium Compounds/*chemistry
Cell Survival/drug effects ; DNA, Mitochondrial/genetics ; HeLa Cells ; Humans ; Imidazoles/chemistry ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitophagy ; Mutation ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Nylons/chemistry ; Reactive Oxygen Species/metabolism ; Surface Plasmon Resonance
Czasopismo naukowe
Tytuł :
Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control.
Autorzy :
Cavinato M; Institute for Biomedical Aging Research, Leopold-Franzens Universität Innsbruck, Austria.; Center for Molecular Biosciences Innsbruck (CMBI), Leopold-Franzens Universität Innsbruck, Austria.
Madreiter-Sokolowski CT; Department of Health Sciences and Technology, Institute of Translational Medicine, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland.; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Austria.
Büttner S; Institute of Molecular Biosciences, University of Graz, Austria.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Sweden.
Schosserer M; Christian Doppler Laboratory for Skin Multimodal Analytical Imaging of Aging and Senescence, Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.; Austrian Cluster for Tissue Regeneration, Medical University of Vienna, Austria.
Zwerschke W; Institute for Biomedical Aging Research, Leopold-Franzens Universität Innsbruck, Austria.; Center for Molecular Biosciences Innsbruck (CMBI), Leopold-Franzens Universität Innsbruck, Austria.
Wedel S; Institute for Biomedical Aging Research, Leopold-Franzens Universität Innsbruck, Austria.; Center for Molecular Biosciences Innsbruck (CMBI), Leopold-Franzens Universität Innsbruck, Austria.
Grillari J; Christian Doppler Laboratory for Skin Multimodal Analytical Imaging of Aging and Senescence, Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.; Austrian Cluster for Tissue Regeneration, Medical University of Vienna, Austria.; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.
Graier WF; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Austria.; BioTechMed Graz, Austria.
Jansen-Dürr P; Institute for Biomedical Aging Research, Leopold-Franzens Universität Innsbruck, Austria.; Center for Molecular Biosciences Innsbruck (CMBI), Leopold-Franzens Universität Innsbruck, Austria.
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Źródło :
The FEBS journal [FEBS J] 2021 Jun; Vol. 288 (12), pp. 3834-3854. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging/*genetics
Cellular Senescence/*genetics
Mitochondria/*genetics
Mitophagy/*genetics
Rejuvenation/*physiology
Aging/metabolism ; Animals ; Calcium Signaling ; Caloric Restriction/methods ; Cells, Cultured ; Gene Expression Regulation ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mitochondria/metabolism ; Mitochondria/pathology ; Oxidative Phosphorylation ; Proteostasis/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Reactive Oxygen Species/metabolism ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin.
Autorzy :
Mehrzadi S; Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Karimi MY; Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Fatemi A; Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reiter RJ; Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA.
Hosseinzadeh A; Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: .
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Źródło :
Pharmacology & therapeutics [Pharmacol Ther] 2021 Aug; Vol. 224, pp. 107825. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19/*drug therapy
Melatonin/*pharmacology
Mitochondria/*pathology
Aged ; Animals ; Antioxidants/administration & dosage ; Antioxidants/pharmacology ; COVID-19/complications ; COVID-19/virology ; Coronavirus Infections/complications ; Coronavirus Infections/virology ; Female ; Humans ; Melatonin/administration & dosage ; Mitochondria/drug effects ; Mitochondria/virology ; Severe Acute Respiratory Syndrome/complications ; Severe Acute Respiratory Syndrome/virology ; Virus Replication
Czasopismo naukowe
Tytuł :
High doses of butyrate induce a reversible body temperature drop through transient proton leak in mitochondria of brain neurons.
Autorzy :
Xu Y; Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Central Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Neurology department, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Peng S; Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Central Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Cao X; Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Central Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Qian S; Central Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Shen S; Central Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Luo J; Central Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Zhang X; Central Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Sun H; School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China.
Shen WL; School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China.
Jia W; Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Ye J; Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Central Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119614. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article
MeSH Terms :
Butyric Acid/*pharmacology
Histamine Antagonists/*pharmacology
Mitochondria/*drug effects
Neurons/*drug effects
Animals ; Body Temperature/drug effects ; Brain/cytology ; Brain/drug effects ; Butyric Acid/administration & dosage ; Butyric Acid/adverse effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Histamine Antagonists/administration & dosage ; Histamine Antagonists/adverse effects ; Male ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Neurons/metabolism ; Protons
Czasopismo naukowe

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