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Wyszukujesz frazę ""molecular chaperones"" wg kryterium: Temat


Tytuł :
High-resolution Crystal Structure of Human pERp1, A Saposin-like Protein Involved in IgA, IgM and Integrin Maturation in the Endoplasmic Reticulum.
Autorzy :
Sowa ST; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland; Biocenter Oulu, Aapistie 5, 90220 Oulu, Finland. Electronic address: .
Moilanen A; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland. Electronic address: .
Biterova E; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland.
Saaranen MJ; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland. Electronic address: .
Lehtiö L; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland; Biocenter Oulu, Aapistie 5, 90220 Oulu, Finland. Electronic address: .
Ruddock LW; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Mar 05; Vol. 433 (5), pp. 166826. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunoglobulin A/*chemistry
Immunoglobulin M/*chemistry
Molecular Chaperones/*chemistry
Saposins/*chemistry
Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/immunology ; Amino Acid Sequence ; Binding Sites ; Calcium/metabolism ; Cloning, Molecular ; Crystallography, X-Ray ; Endoplasmic Reticulum/immunology ; Endoplasmic Reticulum/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Immunity, Humoral ; Immunoglobulin A/genetics ; Immunoglobulin A/immunology ; Immunoglobulin M/genetics ; Immunoglobulin M/immunology ; Models, Molecular ; Molecular Chaperones/genetics ; Molecular Chaperones/immunology ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Folding ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Saposins/genetics ; Saposins/immunology ; Sequence Alignment ; Sequence Homology, Amino Acid ; Substrate Specificity
Czasopismo naukowe
Tytuł :
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones.
Autorzy :
Shemesh N; Department of Clinical Biochemistry and Pharmacology and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.; Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Jubran J; Department of Clinical Biochemistry and Pharmacology and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Dror S; Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Simonovsky E; Department of Clinical Biochemistry and Pharmacology and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Basha O; Department of Clinical Biochemistry and Pharmacology and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Argov C; Department of Clinical Biochemistry and Pharmacology and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Hekselman I; Department of Clinical Biochemistry and Pharmacology and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Abu-Qarn M; Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Vinogradov E; Department of Clinical Biochemistry and Pharmacology and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Mauer O; Department of Clinical Biochemistry and Pharmacology and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Tiago T; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Carra S; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Ben-Zvi A; Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. .
Yeger-Lotem E; Department of Clinical Biochemistry and Pharmacology and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 12; Vol. 12 (1), pp. 2180. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organ Specificity*/genetics
Molecular Chaperones/*metabolism
Aging/metabolism ; Animals ; Caenorhabditis elegans/metabolism ; Cell Line ; Conserved Sequence ; Evolution, Molecular ; Gene Expression Regulation ; Humans ; Mice ; Molecular Chaperones/genetics ; Open Reading Frames/genetics
Czasopismo naukowe
Tytuł :
Progress and prospect of single-molecular ClpX ATPase researching system-a mini-review.
Autorzy :
Kang ZH; School of Bioengineering, Sichuan University of Science & Engineering, Yibin 644005, Sichuan, China. Electronic address: .
Liu YT; School of Bioengineering, Sichuan University of Science & Engineering, Yibin 644005, Sichuan, China.
Gou Y; School of Bioengineering, Sichuan University of Science & Engineering, Yibin 644005, Sichuan, China.
Deng QR; School of Bioengineering, Sichuan University of Science & Engineering, Yibin 644005, Sichuan, China.
Hu ZY; School of Bioengineering, Sichuan University of Science & Engineering, Yibin 644005, Sichuan, China.
Li GR; Southwest University, Beibei 400716, Chongqing, China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Mar 30; Vol. 774, pp. 145420. Date of Electronic Publication: 2021 Jan 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Single Molecule Imaging*
ATPases Associated with Diverse Cellular Activities/*physiology
Endopeptidase Clp/*physiology
Escherichia coli/*enzymology
Escherichia coli Proteins/*physiology
Molecular Chaperones/*physiology
ATPases Associated with Diverse Cellular Activities/chemistry ; Biomedical Research ; Endopeptidase Clp/chemistry ; Escherichia coli Proteins/chemistry ; Metabolic Networks and Pathways ; Mitochondria/physiology ; Models, Molecular ; Molecular Chaperones/chemistry ; Molecular Motor Proteins/chemistry ; Molecular Motor Proteins/physiology ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy.
Autorzy :
Yoon MJ; Department of Life Sciences, Korea University, Seoul, Republic of Korea.
Choi B; Department of Anatomy, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim EJ; Department of Life Sciences, Korea University, Seoul, Republic of Korea.
Ohk J; Department of Anatomy, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Yang C; Department of Life Sciences, Korea University, Seoul, Republic of Korea.
Choi YG; Department of Life Sciences, Korea University, Seoul, Republic of Korea.
Lee J; Department of Life Sciences, Korea University, Seoul, Republic of Korea.
Kang C; School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Song HK; Department of Life Sciences, Korea University, Seoul, Republic of Korea.
Kim YK; Department of Life Sciences, Korea University, Seoul, Republic of Korea.
Woo JS; Department of Life Sciences, Korea University, Seoul, Republic of Korea.
Cho Y; Department of Life Sciences, Korea University, Seoul, Republic of Korea.
Choi EJ; Department of Life Sciences, Korea University, Seoul, Republic of Korea.
Jung H; Department of Anatomy, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea. .
Kim C; Department of Life Sciences, Korea University, Seoul, Republic of Korea. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 29; Vol. 12 (1), pp. 1955. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Aggregates*/drug effects
Autophagy/*genetics
Cell Cycle Proteins/*genetics
Molecular Chaperones/*genetics
Sequestosome-1 Protein/*genetics
Superoxide Dismutase-1/*genetics
Animals ; Autophagy/drug effects ; Cell Cycle Proteins/metabolism ; Ganglia, Spinal/cytology ; Ganglia, Spinal/metabolism ; Gene Expression Regulation ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Leupeptins/pharmacology ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Molecular Chaperones/metabolism ; Motor Neurons/cytology ; Motor Neurons/drug effects ; Motor Neurons/metabolism ; Primary Cell Culture ; Proteasome Endopeptidase Complex/drug effects ; Proteasome Endopeptidase Complex/metabolism ; Protein Folding/drug effects ; Sequestosome-1 Protein/metabolism ; Signal Transduction ; Superoxide Dismutase-1/metabolism ; Transgenes ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors.
Autorzy :
Shi Y; Department of Cell and Molecular Biology, Karolinska Institutet, Solnavägen 9, SE-171 65 Stockholm, Sweden.
Yuan J; Department of Cell and Molecular Biology, Karolinska Institutet, Solnavägen 9, SE-171 65 Stockholm, Sweden.
Rraklli V; Department of Cell and Molecular Biology, Karolinska Institutet, Solnavägen 9, SE-171 65 Stockholm, Sweden.
Maxymovitz E; Department of Cell and Molecular Biology, Karolinska Institutet, Solnavägen 9, SE-171 65 Stockholm, Sweden.
Cipullo M; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solnavägen 9, SE-171-65 Solna, Sweden.
Liu M; Department of Cell and Molecular Biology, Karolinska Institutet, Solnavägen 9, SE-171 65 Stockholm, Sweden.
Li S; Department of Microbiology, Tumor- and Cellbiology, Karolinska Institutet, Solnavägen 9, SE-171 65 Solna, Sweden.
Westerlund I; Department of Cell and Molecular Biology, Karolinska Institutet, Solnavägen 9, SE-171 65 Stockholm, Sweden.
Bedoya-Reina OC; Department of Microbiology, Tumor- and Cellbiology, Karolinska Institutet, Solnavägen 9, SE-171 65 Solna, Sweden.
Bullova P; Department of Microbiology, Tumor- and Cellbiology, Karolinska Institutet, Solnavägen 9, SE-171 65 Solna, Sweden.
Rorbach J; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solnavägen 9, SE-171-65 Solna, Sweden.
Juhlin CC; Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Stenman A; Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Larsson C; Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Kogner P; Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
O'Sullivan MJ; Department of Histopathology, Our Lady's Children's Hospital, Dublin, Ireland.; Trinity Translational Medicine Institute, Trinity College, Dublin, Ireland.
Schlisio S; Department of Microbiology, Tumor- and Cellbiology, Karolinska Institutet, Solnavägen 9, SE-171 65 Solna, Sweden.
Holmberg J; Department of Cell and Molecular Biology, Karolinska Institutet, Solnavägen 9, SE-171 65 Stockholm, Sweden.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2509-2521.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Splicing*
Molecular Chaperones/*genetics
Mutant Chimeric Proteins/*genetics
Neuroblastoma/*genetics
Spliceosomes/*drug effects
Aminoacyltransferases/metabolism ; Animals ; Apoptosis ; Cell Differentiation ; Cell Line, Tumor ; Female ; Gene Fusion ; HSC70 Heat-Shock Proteins/metabolism ; Humans ; Mice, Nude ; Molecular Chaperones/metabolism ; Mutant Chimeric Proteins/metabolism ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; RNA Splicing Factors/genetics ; RNA Splicing Factors/metabolism ; Sequence Deletion ; Transcription Factors/metabolism ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
ClpXP-mediated Degradation of the TAC Antitoxin is Neutralized by the SecB-like Chaperone in Mycobacterium tuberculosis.
Autorzy :
Texier P; Laboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France.
Bordes P; Laboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France. Electronic address: .
Nagpal J; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.
Sala AJ; Laboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France.
Mansour M; Laboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France.
Cirinesi AM; Laboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France.
Xu X; Laboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France.
Dougan DA; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia. Electronic address: .
Genevaux P; Laboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Mar 05; Vol. 433 (5), pp. 166815. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Bacterial*
ATPases Associated with Diverse Cellular Activities/*genetics
Bacterial Proteins/*genetics
Endopeptidase Clp/*genetics
Escherichia coli Proteins/*genetics
Molecular Chaperones/*genetics
Mycobacterium tuberculosis/*genetics
Toxin-Antitoxin Systems/*genetics
ATPases Associated with Diverse Cellular Activities/metabolism ; Bacterial Proteins/metabolism ; Cloning, Molecular ; Endopeptidase Clp/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Genome, Bacterial ; Molecular Chaperones/metabolism ; Mycobacterium tuberculosis/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Proteolysis ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Mechanisms of productive folding and endoplasmic reticulum-associated degradation of glycoproteins and non-glycoproteins.
Autorzy :
Ninagawa S; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. Electronic address: .
George G; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
Mori K; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2021 Mar; Vol. 1865 (3), pp. 129812. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Endoplasmic Reticulum-Associated Degradation*
Protein Processing, Post-Translational*
Endoplasmic Reticulum/*metabolism
Glycoproteins/*metabolism
Molecular Chaperones/*metabolism
Protein Disulfide-Isomerases/*metabolism
Animals ; Endoplasmic Reticulum/genetics ; Gene Editing/methods ; Glycoproteins/genetics ; Glycosylation ; Molecular Chaperones/genetics ; Oligosaccharides/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Protein Biosynthesis ; Protein Disulfide-Isomerases/genetics ; Protein Folding ; Protein Transport ; Proteolysis ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
First Virtual International Congress on Cellular and Organismal Stress Responses, November 5-6, 2020.
Autorzy :
van Oosten-Hawle P; School of Molecular and Cell Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK. .
Bergink S; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, Groningen, AV, 9713, The Netherlands.
Blagg B; Department of Chemistry & Biochemistry, College of Science, University of Notre Dame, Notre Dame, IN, USA.
Brodsky J; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Edkins A; Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, 6140, South Africa.; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown, 6140, South Africa.
Freeman B; Department of Cell and Developmental Biology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Genest O; Aix Marseille University, CNRS, BIP UMR, 7281, Marseille, France.
Hendershot L; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Kampinga H; Department of Cell Biology, University of Groningen, University Medical Center Groningen, Ant. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Johnson J; Department of Biological Sciences and the Center for Reproductive Biology, University of Idaho, Moscow, ID, 83844, USA.
De Maio A; Division of Trauma, Critical Care, Burns and Acute Care Surgery, Department of Surgery, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Masison D; Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 8 Center Dr, Room 324, Bethesda, MD, 20892, USA.
Morano K; Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, Houston, TX, 77030, USA.
Multhoff G; Radiation Immuno-Oncology Group, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich (TUM), 81675, Munich, Germany.; Department of Radiation Oncology, School of Medicine, Technical University of Munich (TUM), 81675, Munich, Germany.
Prodromou C; Genome Damage and Stability Centre, University of Sussex, Brighton, BN1 9RQ, UK.
Prahlad V; Department of Biology, Aging Mind and Brain Initiative, University of Iowa, Iowa City, IA, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.
Scherz-Shouval R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Zhuravleva A; School of Molecular and Cell Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.
Mollapour M; Department of Urology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA. .; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA. .; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, 13210, USA. .
Truman AW; Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, 28223, USA. .
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Źródło :
Cell stress & chaperones [Cell Stress Chaperones] 2021 Mar; Vol. 26 (2), pp. 289-295. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Heat-Shock Proteins/*metabolism
Molecular Chaperones/*metabolism
HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; HSP90 Heat-Shock Proteins/genetics ; HSP90 Heat-Shock Proteins/metabolism ; Heat-Shock Proteins/genetics ; Humans ; Molecular Chaperones/genetics ; Proteostasis/genetics ; Proteostasis/physiology
Czasopismo naukowe
Tytuł :
Mechanistic Insights into the Role of Molecular Chaperones in Protein Misfolding Diseases: From Molecular Recognition to Amyloid Disassembly.
Autorzy :
Hervás R; Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Oroz J; Rocasolano Institute for Physical Chemistry, Spanish National Research Council (IQFR-CSIC), Serrano 119, E-28006 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 02; Vol. 21 (23). Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Disease Susceptibility*
Molecular Chaperones/*chemistry
Molecular Chaperones/*metabolism
Proteostasis Deficiencies/*etiology
Proteostasis Deficiencies/*metabolism
Amyloid/metabolism ; Animals ; HSP70 Heat-Shock Proteins/chemistry ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; HSP90 Heat-Shock Proteins/chemistry ; HSP90 Heat-Shock Proteins/genetics ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Molecular Chaperones/genetics ; Molecular Chaperones/isolation & purification ; Protein Aggregation, Pathological ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Probing the Role of Catalytic Triad on the Cleavage between Intramolecular Chaperone and NK Mature Peptide.
Autorzy :
Yang M; Beijing Key Laboratory of Plants Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.
Wu J; Beijing Key Laboratory of Plants Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.
Huang Q; Department of Food Science, Rutgers University, New Brunswick NJ08901, United States.
Jia Y; Beijing Key Laboratory of Plants Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Feb 24; Vol. 69 (7), pp. 2348-2353. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Chaperones*/genetics
Molecular Chaperones*/metabolism
Subtilisins*
Models, Molecular ; Peptides ; Protein Folding
Czasopismo naukowe
Tytuł :
Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone.
Autorzy :
Ryder BD; Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Matlahov I; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Zernike Institute for Advanced Materials, University of Groningen, Groningen, Netherlands.
Bali S; Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Vaquer-Alicea J; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Neuroscience Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, USA.
van der Wel PCA; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. .; Zernike Institute for Advanced Materials, University of Groningen, Groningen, Netherlands. .
Joachimiak LA; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA. .; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 11; Vol. 12 (1), pp. 946. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
HSP40 Heat-Shock Proteins/*metabolism
HSP70 Heat-Shock Proteins/*metabolism
Molecular Chaperones/*metabolism
Nerve Tissue Proteins/*metabolism
Biological Evolution ; HEK293 Cells ; HSP40 Heat-Shock Proteins/chemistry ; HSP40 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/chemistry ; Humans ; Models, Molecular ; Molecular Chaperones/chemistry ; Molecular Chaperones/genetics ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/genetics ; Protein Binding ; Protein Domains ; Protein Folding ; Proteostasis ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Detection of key sites of dimer dissociation and unfolding initiation during activation of acid-stress chaperone HdeA at low pH.
Autorzy :
Widjaja MA; Department of Chemistry and Biochemistry, California State University Northridge, 18111 Nordhoff St., Northridge, CA 91330-8262, United States of America.
Gomez JS; Department of Chemistry and Biochemistry, California State University Northridge, 18111 Nordhoff St., Northridge, CA 91330-8262, United States of America.
Benson JM; Department of Chemistry and Biochemistry, California State University Northridge, 18111 Nordhoff St., Northridge, CA 91330-8262, United States of America.
Crowhurst KA; Department of Chemistry and Biochemistry, California State University Northridge, 18111 Nordhoff St., Northridge, CA 91330-8262, United States of America. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2021 Feb; Vol. 1869 (2), pp. 140576. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Conformation*
Escherichia coli/*genetics
Escherichia coli Proteins/*genetics
Molecular Chaperones/*genetics
Acids/pharmacology ; Escherichia coli/chemistry ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/ultrastructure ; Humans ; Hydrogen-Ion Concentration ; Molecular Chaperones/chemistry ; Molecular Chaperones/ultrastructure ; Molecular Dynamics Simulation ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Multimerization/genetics ; Protein Unfolding
Czasopismo naukowe
Tytuł :
VBP1 modulates Wnt/β-catenin signaling by mediating the stability of the transcription factors TCF/LEFs.
Autorzy :
Zhang H; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao, China.
Rong X; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao, China. Electronic address: .
Wang C; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao, China.
Liu Y; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao, China.
Lu L; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao, China.
Li Y; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao, China.
Zhao C; Institute of Evolution and Marine Biodiversity and College of Marine Biology, Ocean University of China, Qingdao, China; Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology, Qingdao, China.
Zhou J; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao, China. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 04; Vol. 295 (49), pp. 16826-16839. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Wnt Signaling Pathway*
Cytoskeletal Proteins/*metabolism
Molecular Chaperones/*metabolism
TCF Transcription Factors/*metabolism
Animals ; Cell Line ; Cell Proliferation ; Cytoskeletal Proteins/antagonists & inhibitors ; Cytoskeletal Proteins/genetics ; Embryo, Nonmammalian/metabolism ; Humans ; Molecular Chaperones/antagonists & inhibitors ; Molecular Chaperones/genetics ; Phosphorylation ; RNA Interference ; RNA, Small Interfering/metabolism ; TCF Transcription Factors/genetics ; Transcription Factor 7-Like 1 Protein/genetics ; Transcription Factor 7-Like 1 Protein/metabolism ; Transcription Factor 7-Like 2 Protein/genetics ; Transcription Factor 7-Like 2 Protein/metabolism ; Transcriptional Activation ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Zebrafish/growth & development ; Zebrafish/metabolism ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism ; beta Catenin/genetics ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone.
Autorzy :
Batista FAH; São Carlos Institute of Chemistry (IQSC), University of São Paulo (USP), São Carlos, Brazil.
Ramos SL Jr; São Carlos Institute of Chemistry (IQSC), University of São Paulo (USP), São Carlos, Brazil.
Tassone G; Department of Biotechnology, Chemistry and Pharmacy - Department of Excellence 2018-2022, University of Siena, Siena, Italy.
Leitão A; Medicinal Chemistry Group (NEQUIMED), IQSC-USP, University of São Paulo, São Carlos, Brazil.
Montanari CA; Medicinal Chemistry Group (NEQUIMED), IQSC-USP, University of São Paulo, São Carlos, Brazil.
Botta M; Department of Biotechnology, Chemistry and Pharmacy - Department of Excellence 2018-2022, University of Siena, Siena, Italy.; Lead Discovery Siena S.r., Siena, Italy.; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA.
Mori M; Department of Biotechnology, Chemistry and Pharmacy - Department of Excellence 2018-2022, University of Siena, Siena, Italy.
Borges JC; São Carlos Institute of Chemistry (IQSC), University of São Paulo (USP), São Carlos, Brazil.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 639-649.
Typ publikacji :
Journal Article
MeSH Terms :
Antiprotozoal Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
HSP90 Heat-Shock Proteins/*antagonists & inhibitors
Leishmania braziliensis/*drug effects
Molecular Chaperones/*pharmacology
Small Molecule Libraries/*pharmacology
Adenosine Triphosphatases/antagonists & inhibitors ; Adenosine Triphosphatases/metabolism ; Antiprotozoal Agents/chemical synthesis ; Antiprotozoal Agents/chemistry ; Dose-Response Relationship, Drug ; Drug Discovery ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; HSP90 Heat-Shock Proteins/metabolism ; Leishmania braziliensis/chemistry ; Models, Molecular ; Molecular Chaperones/chemical synthesis ; Molecular Chaperones/chemistry ; Molecular Structure ; Parasitic Sensitivity Tests ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Circ-CCS is identified as a cancer-promoting circRNA in lung cancer partly by regulating the miR-383/E2F7 axis.
Autorzy :
Yuan Y; Department of Respiratory and Critical Care Ward 3, Henan Provincial Chest Hospital, Zhengzhou, Henan, China.
Zhou X; Department of Respiratory and Critical Care Ward 3, Henan Provincial Chest Hospital, Zhengzhou, Henan, China.
Kang Y; Department Two of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Kuang H; Department of Respiratory and Critical Care Ward 3, Henan Provincial Chest Hospital, Zhengzhou, Henan, China.
Peng Q; Department of Respiratory and Critical Care Ward 3, Henan Provincial Chest Hospital, Zhengzhou, Henan, China.
Zhang B; Department of Respiratory and Critical Care Ward 3, Henan Provincial Chest Hospital, Zhengzhou, Henan, China.
Liu X; Department of Respiratory and Critical Care Ward 3, Henan Provincial Chest Hospital, Zhengzhou, Henan, China.
Zhang M; Department of Respiratory and Critical Care Ward 3, Henan Provincial Chest Hospital, Zhengzhou, Henan, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 15; Vol. 267, pp. 118955. Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
E2F7 Transcription Factor/*genetics
MicroRNAs/*genetics
Molecular Chaperones/*genetics
Apoptosis/genetics ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cell Survival/genetics ; Disease Progression ; E2F7 Transcription Factor/metabolism ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; MicroRNAs/metabolism ; Molecular Chaperones/metabolism ; RNA, Circular/genetics ; RNA, Circular/metabolism ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
The antioxidant function of Sco proteins depends on a critical surface-exposed residue.
Autorzy :
Ekim Kocabey A; Institute of Genetics, Technische Universität Dresden, 01062 Dresden, Germany.
Rödel G; Institute of Genetics, Technische Universität Dresden, 01062 Dresden, Germany.
Gey U; Institute of Genetics, Technische Universität Dresden, 01062 Dresden, Germany. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2021 Feb; Vol. 1865 (2), pp. 129781. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidants/*chemistry
Arabidopsis/*chemistry
Arabidopsis Proteins/*chemistry
Fungal Proteins/*chemistry
Kluyveromyces/*chemistry
Molecular Chaperones/*chemistry
Amino Acid Motifs ; Amino Acid Sequence ; Antioxidants/metabolism ; Arabidopsis/metabolism ; Arabidopsis Proteins/metabolism ; Conserved Sequence ; Fungal Proteins/metabolism ; Humans ; Kluyveromyces/metabolism ; Molecular Chaperones/metabolism ; Oxidative Stress
SCR Organism :
Kluyveromyces lactis
Czasopismo naukowe
Tytuł :
A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae.
Autorzy :
Rodríguez-Galán O; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; Departamento de Genética, Universidad de Sevilla, Seville, Spain.
García-Gómez JJ; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; Departamento de Genética, Universidad de Sevilla, Seville, Spain.
Rosado IV; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; Departamento de Genética, Universidad de Sevilla, Seville, Spain.
Wei W; Stanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.; CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Méndez-Godoy A; Unit of Biochemistry, Department of Biology, University of Fribourg, Fribourg, Switzerland.
Pillet B; Unit of Biochemistry, Department of Biology, University of Fribourg, Fribourg, Switzerland.
Alekseenko A; SciLifeLab, Department of Microbiology, Tumor and Cell Biology. Karolinska Institutet, Solna, Sweden.
Steinmetz LM; Stanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.; Department of Genetics, School of Medicine, Stanford, CA, USA.
Pelechano V; SciLifeLab, Department of Microbiology, Tumor and Cell Biology. Karolinska Institutet, Solna, Sweden.
Kressler D; Unit of Biochemistry, Department of Biology, University of Fribourg, Fribourg, Switzerland.
de la Cruz J; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; Departamento de Genética, Universidad de Sevilla, Seville, Spain.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 11; Vol. 49 (1), pp. 206-220.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Folding*
Molecular Chaperones/*physiology
Multiprotein Complexes/*physiology
Peptide Chain Elongation, Translational/*physiology
Proteostasis/*physiology
Ribosomes/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*physiology
Alleles ; Loss of Function Mutation ; Molecular Chaperones/genetics ; Mutation, Missense ; Peptidyl Transferases/physiology ; Point Mutation ; Recombinant Proteins/metabolism ; Ribosomal Proteins/genetics ; Ribosomal Proteins/physiology ; Ribosomes/ultrastructure ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
Biochemical Characterization of the Integrin Interactome.
Autorzy :
Khan RB; School of Biosciences, University of Kent, Kent, UK.
Varela L; School of Biosciences, University of Kent, Kent, UK.
Cowell AR; School of Biosciences, University of Kent, Kent, UK.
Goult BT; School of Biosciences, University of Kent, Kent, UK. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2217, pp. 115-147.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Actins/*metabolism
Circular Dichroism/*methods
Integrins/*metabolism
Magnetic Resonance Spectroscopy/*methods
Molecular Chaperones/*metabolism
Protein Interaction Mapping/*methods
Actins/genetics ; Cell Adhesion ; Chromatography, Gel ; Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Integrins/genetics ; Mechanotransduction, Cellular ; Molecular Chaperones/genetics ; Mutagenesis, Site-Directed ; Protein Binding ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism
Czasopismo naukowe
Tytuł :
Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1.
Autorzy :
Luithle N; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.
de Bos JU; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.; Molecular Life Sciences Ph.D. Program, Zurich, Switzerland.
Hovius R; Institute of Chemical Sciences and Engineering - ISIC, EPFL, Lausanne, Switzerland.
Maslennikova D; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.; Molecular Life Sciences Ph.D. Program, Zurich, Switzerland.
Lewis RT; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.; Molecular Life Sciences Ph.D. Program, Zurich, Switzerland.
Ungricht R; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.
Fierz B; Institute of Chemical Sciences and Engineering - ISIC, EPFL, Lausanne, Switzerland.
Kutay U; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.
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Źródło :
ELife [Elife] 2020 Dec 15; Vol. 9. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin/*metabolism
Chromosome Segregation/*physiology
HSC70 Heat-Shock Proteins/*metabolism
Mitosis/*physiology
Molecular Chaperones/*metabolism
Adenosine Triphosphatases/metabolism ; Carrier Proteins/metabolism ; Cell Line, Tumor ; Gene Knockout Techniques ; HCT116 Cells ; HSC70 Heat-Shock Proteins/genetics ; HeLa Cells ; Hep G2 Cells ; Humans ; Molecular Chaperones/genetics ; Nuclear Envelope/metabolism
Czasopismo naukowe

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