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Tytuł:
Transcriptomics analysis revealed that TAZ regulates the proliferation of KIRC cells through mitophagy.
Autorzy:
He Z; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.; Department of Urology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
Shi J; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Zhu B; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Tian Z; Department of Urology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
Zhang Z; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China. .
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Źródło:
BMC cancer [BMC Cancer] 2024 Feb 19; Vol. 24 (1), pp. 229. Date of Electronic Publication: 2024 Feb 19.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Renal Cell*/genetics
Carcinoma, Renal Cell*/pathology
Kidney Neoplasms*/genetics
Kidney Neoplasms*/pathology
Mitophagy*/genetics
Transcriptional Coactivator with PDZ-Binding Motif Proteins*/genetics
Humans ; Cell Proliferation/genetics ; Gene Expression Profiling ; Intracellular Signaling Peptides and Proteins/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TRIM25 promotes glioblastoma cell growth and invasion via regulation of the PRMT1/c-MYC pathway by targeting the splicing factor NONO.
Autorzy:
Chen Y; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China.
Xu X; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China.
Ding K; Department of Radiation Oncology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.
Tang T; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China.
Cai F; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China.
Zhang H; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China.
Chen Z; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China.
Qi Y; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China.
Fu Z; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China.
Zhu G; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China.
Dou Z; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China.
Xu J; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China.
Chen G; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China.
Wu Q; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China. .; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China. .
Ji J; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China. .; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China. .
Zhang J; Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China. .; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310000, Zhejiang, P. R. China. .; Brain Research Institute, Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China. .; MOE Frontier Science Center for Brain Science & Brain-Machine Integration Zhejiang University, Hangzhou, 310000, Zhejiang, P. R. China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Feb 02; Vol. 43 (1), pp. 39. Date of Electronic Publication: 2024 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Glioblastoma*/metabolism
Glioblastoma*/pathology
Transcription Factors*/genetics
Transcription Factors*/metabolism
Tripartite Motif Proteins*
Humans ; Cell Line, Tumor ; Cell Proliferation ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Protein-Arginine N-Methyltransferases/genetics ; Protein-Arginine N-Methyltransferases/metabolism ; Repressor Proteins/metabolism ; RNA Splicing Factors/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TAZ acting as a potential pathogenic biomarker to promote the development of lichen planus.
Autorzy:
Wang N; Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Bai R; Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Cheng B; Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Luo R; Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
He K; Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Du W; Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yin T; Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Liang Q; Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Zheng Y; Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
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Źródło:
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) [Skin Res Technol] 2024 Feb; Vol. 30 (2), pp. e13597.
Typ publikacji:
Journal Article
MeSH Terms:
Lichen Planus*/pathology
Transcriptional Coactivator with PDZ-Binding Motif Proteins*/genetics
Humans ; Biomarkers/metabolism ; Dermis/pathology ; Epidermis/metabolism ; Immunohistochemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Functional Analysis of KAP1/TRIM28 Requirements for HIV-1 Transcription Activation.
Autorzy:
Randolph K; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Hyder U; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Challa A; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Perez E; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
D'Orso I; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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Źródło:
Viruses [Viruses] 2024 Jan 13; Vol. 16 (1). Date of Electronic Publication: 2024 Jan 13.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*/genetics
Transcriptional Activation*
Tripartite Motif-Containing Protein 28*/genetics
Humans ; Mutagenesis ; RING Finger Domains
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pteropus vampyrus TRIM40 Is an Interferon-Stimulated Gene That Antagonizes RIG-I-like Receptors.
Autorzy:
van Tol S; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Hage A; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Rajsbaum R; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.; Center for Virus-Host-Innate-Immunity and Department of Medicine, RBHS Institute for Infectious and Inflammatory Diseases, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ 07103, USA.; Institute for Human Infections and Immunity, Sealy & Smith Foundation, University of Texas Medical Branch, Galveston, TX 77555, USA.
Freiberg AN; Institute for Human Infections and Immunity, Sealy & Smith Foundation, University of Texas Medical Branch, Galveston, TX 77555, USA.; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.
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Źródło:
Viruses [Viruses] 2023 Oct 25; Vol. 15 (11). Date of Electronic Publication: 2023 Oct 25.
Typ publikacji:
Journal Article
MeSH Terms:
Chiroptera*/immunology
Chiroptera*/virology
Henipavirus Infections*
Tripartite Motif Proteins*/metabolism
DEAD Box Protein 58*/antagonists & inhibitors
DEAD Box Protein 58*/metabolism
Animals ; Humans ; Immunity, Innate ; Interferons/genetics ; Nipah Virus/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tripartite motif‑containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
Autorzy:
Hou H; Department of Cardiology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310000, P.R. China.
Chen Y; Department of Cardiology, Ezhou Central Hospital, Ezhou, Hubei 436000, P.R. China.
Feng X; Department of Cardiology, Ezhou Central Hospital, Ezhou, Hubei 436000, P.R. China.
Xu G; Department of Cardiology, Ezhou Central Hospital, Ezhou, Hubei 436000, P.R. China.
Yan M; Department of General Practice, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310000, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2023 Sep; Vol. 28 (3). Date of Electronic Publication: 2023 Jul 28.
Typ publikacji:
Journal Article
MeSH Terms:
Myocytes, Cardiac*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Tripartite Motif Proteins*/metabolism
Animals ; Mice ; Rats ; Animals, Newborn ; Cardiomegaly/metabolism ; Fibrosis ; Glycogen Synthase Kinase 3 beta/metabolism ; Mice, Inbred C57BL ; Mice, Transgenic ; Phenylephrine/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Trimming away tau in neurodegeneration.
Autorzy:
Noble W; University of Exeter, Exeter, UK.
Hanger DP; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Jul 28; Vol. 381 (6656), pp. 377-378. Date of Electronic Publication: 2023 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*
Tripartite Motif Proteins*
Ubiquitin-Protein Ligases*
Animals ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
New insights into the ambivalent role of YAP/TAZ in human cancers.
Autorzy:
Luo J; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China.
Deng L; Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China.
Zou H; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China.
Guo Y; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China.
Tong T; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China.; Department of Urology, Pelvic Floor Disorders Center, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China.
Huang M; Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China.
Ling G; Department of Neurosurgery, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China.
Li P; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China. .; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 May 22; Vol. 42 (1), pp. 130. Date of Electronic Publication: 2023 May 22.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Neoplasms*/pathology
Transcriptional Coactivator with PDZ-Binding Motif Proteins*
YAP-Signaling Proteins*
Humans ; Phosphoproteins/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction ; Trans-Activators/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SP140 inhibitor suppressing TRIM22 expression regulates glioma progress through PI3K/AKT signaling pathway.
Autorzy:
Li X; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.; Department of Neurosurgery, Xinghua People's Hospital, Xinghua, China.
Li G; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.; Department of Neurosurgery, Hefei First People's Hospital, Hefei, China.
Li L; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Gao B; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Niu X; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.; Department of Neurosurgery, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, China.
Wang Y; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.; Department of Neurosurgery, Yancheng Third People's Hospital, Yancheng, China.
Wang Z; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
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Źródło:
Brain and behavior [Brain Behav] 2024 Mar; Vol. 14 (3), pp. e3465.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Glioma*/drug therapy
Glioma*/genetics
Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Proliferation ; Signal Transduction ; Tripartite Motif Proteins/genetics ; Tripartite Motif Proteins/pharmacology ; Repressor Proteins/metabolism ; Minor Histocompatibility Antigens/pharmacology ; Transcription Factors ; Antigens, Nuclear/metabolism ; Antigens, Nuclear/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TRIM72 restricts lyssavirus infection by inducing K48-linked ubiquitination and proteasome degradation of the matrix protein.
Autorzy:
Sui B; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Zheng J; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Fu Z; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Zhao L; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Frontiers Science Center for Animal Breeding and Sustainable Production, Wuhan China.; Hubei Hongshan Laboratory, Wuhan, China.
Zhou M; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
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Źródło:
PLoS pathogens [PLoS Pathog] 2024 Feb 26; Vol. 20 (2), pp. e1011718. Date of Electronic Publication: 2024 Feb 26 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Proteasome Endopeptidase Complex*/metabolism
Lyssavirus*/genetics
Mice ; Animals ; Proteins/metabolism ; Ubiquitination ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Tripartite Motif Proteins/genetics ; Tripartite Motif Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TRIM9 Interacts with ZEB1 to Suppress Esophageal Cancer by Promoting ZEB1 Protein Degradation via the UPP Pathway.
Autorzy:
Lin Z; Department of Thoracic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No. 134, East Street, Fuzhou 350001, China.
Huang J; Department of Thoracic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No. 134, East Street, Fuzhou 350001, China.
Zhu L; Department of Thoracic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No. 134, East Street, Fuzhou 350001, China.
Lin X; Department of Thoracic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No. 134, East Street, Fuzhou 350001, China.
Huang Y; Department of Thoracic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No. 134, East Street, Fuzhou 350001, China.
Chen C; Department of Thoracic Surgery, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Gulou District, Fuzhou 350001, China.
Pan X; Department of Thoracic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No. 134, East Street, Fuzhou 350001, China.
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Źródło:
BioMed research international [Biomed Res Int] 2023 Apr 20; Vol. 2023, pp. 2942402. Date of Electronic Publication: 2023 Apr 20 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Esophageal Neoplasms*/genetics
Esophageal Neoplasms*/pathology
MicroRNAs*/genetics
Zinc Finger E-box-Binding Homeobox 1*/genetics
Zinc Finger E-box-Binding Homeobox 1*/metabolism
Tripartite Motif Proteins*/genetics
Tripartite Motif Proteins*/metabolism
Humans ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor ; Proteolysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Autorzy:
Mukadam AS; UK Dementia Research Institute at the University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
Miller LVC; UK Dementia Research Institute at the University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
Smith AE; UK Dementia Research Institute at the University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
Vaysburd M; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Sakya SA; Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, N-0424 Oslo, Norway.; Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, N-0372 Oslo, Norway.
Sanford S; UK Dementia Research Institute at the University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
Keeling S; UK Dementia Research Institute at the University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
Tuck BJ; UK Dementia Research Institute at the University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
Katsinelos T; UK Dementia Research Institute at the University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
Green C; UK Dementia Research Institute at the University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
Skov L; UK Dementia Research Institute at the University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
Kaalund SS; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
Foss S; Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, N-0424 Oslo, Norway.; Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, N-0372 Oslo, Norway.
Mayes K; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
O'Connell K; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Wing M; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Knox C; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Banbury J; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Avezov E; UK Dementia Research Institute at the University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
Rowe JB; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.; Cambridge University Hospitals NHS Trust, Cambridge CB2 0SZ, UK.
Goedert M; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Andersen JT; Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, N-0424 Oslo, Norway.; Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, N-0372 Oslo, Norway.
James LC; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
McEwan WA; UK Dementia Research Institute at the University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Mar 31; Vol. 379 (6639), pp. 1336-1341. Date of Electronic Publication: 2023 Mar 30.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Monoclonal*/immunology
Antibodies, Monoclonal*/therapeutic use
Immunization, Passive*
Ribonucleoproteins*/genetics
Ribonucleoproteins*/metabolism
tau Proteins*/immunology
Tauopathies*/therapy
Tripartite Motif Proteins*/genetics
Tripartite Motif Proteins*/metabolism
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Animals ; Mice ; Cytosol/metabolism ; Disease Models, Animal ; Receptors, Fc
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pregnancy Is Associated with Impaired Transcription of Human Endogenous Retroviruses and of TRIM28 and SETDB1, Particularly in Mothers Affected by Multiple Sclerosis.
Autorzy:
Tovo PA; Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
Marozio L; Department of Surgical Sciences, Obstetrics and Gynecology 1, University of Turin, 10126 Turin, Italy.
Abbona G; Pathology Unit, Department Laboratory Medicine, AOU Città della Salute e della Scienza di Torino, 10126 Turin, Italy.
Calvi C; Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.; Pediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
Frezet F; Department of Surgical Sciences, Obstetrics and Gynecology 1, University of Turin, 10126 Turin, Italy.
Gambarino S; Pediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
Dini M; Pediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
Benedetto C; Department of Surgical Sciences, Obstetrics and Gynecology 1, University of Turin, 10126 Turin, Italy.
Galliano I; Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.; Pediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
Bergallo M; Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.; Pediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
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Źródło:
Viruses [Viruses] 2023 Mar 09; Vol. 15 (3). Date of Electronic Publication: 2023 Mar 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endogenous Retroviruses*/genetics
Histone-Lysine N-Methyltransferase*/genetics
Histone-Lysine N-Methyltransferase*/metabolism
Multiple Sclerosis*
Tripartite Motif-Containing Protein 28*/genetics
Tripartite Motif-Containing Protein 28*/metabolism
Pregnancy Complications*
Female ; Humans ; Infant, Newborn ; Pregnancy ; Genes, env ; Mothers ; RNA, Messenger ; Epigenesis, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Small-Molecule Inhibition of MuRF1 Prevents Early Disuse-Induced Diaphragmatic Dysfunction and Atrophy.
Autorzy:
Ribeiro F; Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Alves PKN; Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Bechara LRG; Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Ferreira JCB; Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Labeit S; DZHK Partner Site Mannheim-Heidelberg, Medical Faculty Mannheim, University of Heidelberg, 68169 Mannheim, Germany.; Myomedix GmbH, 69151 Neckargemünd, Germany.
Moriscot AS; Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 11; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 11.
Typ publikacji:
Journal Article
MeSH Terms:
Diaphragm*/metabolism
Diaphragm*/pathology
Muscular Atrophy*/metabolism
Ubiquitin-Protein Ligases*/antagonists & inhibitors
Ubiquitin-Protein Ligases*/metabolism
Tripartite Motif Proteins*/antagonists & inhibitors
Tripartite Motif Proteins*/metabolism
Animals ; Rats ; Oxidative Stress ; Rats, Wistar ; Respiration, Artificial/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genetic Profiling of African American Patients With Prostatic Adenocarcinoma Metastatic to the Lymph Nodes: A Pilot Study.
Autorzy:
Bidot S; From the Departments of Pathology and Laboratory Medicine (Bidot, Zhang, Deeb, Smith, Hill, Tinsley, Harik).
Yin J; Department of Clinical and Translational Research, Caris Life Sciences, Phoenix, Arizona (Yin, Xiu).
Zhou P; Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York (Zhou).
Zhang L; From the Departments of Pathology and Laboratory Medicine (Bidot, Zhang, Deeb, Smith, Hill, Tinsley, Harik).
Deeb KK; From the Departments of Pathology and Laboratory Medicine (Bidot, Zhang, Deeb, Smith, Hill, Tinsley, Harik).
Smith G; From the Departments of Pathology and Laboratory Medicine (Bidot, Zhang, Deeb, Smith, Hill, Tinsley, Harik).
Hill CE; From the Departments of Pathology and Laboratory Medicine (Bidot, Zhang, Deeb, Smith, Hill, Tinsley, Harik).
Xiu J; Department of Clinical and Translational Research, Caris Life Sciences, Phoenix, Arizona (Yin, Xiu).
Bilen MA; Hematology and Oncology (Bilen, Carthon).; Winship Cancer Institute of Emory University, Atlanta, GA (Bilen, Harik).
Case KB; Emory University School of Medicine, Atlanta, Georgia (Case).
Tinsley M; From the Departments of Pathology and Laboratory Medicine (Bidot, Zhang, Deeb, Smith, Hill, Tinsley, Harik).
Carthon B; Hematology and Oncology (Bilen, Carthon).
Harik LR; From the Departments of Pathology and Laboratory Medicine (Bidot, Zhang, Deeb, Smith, Hill, Tinsley, Harik).; Winship Cancer Institute of Emory University, Atlanta, GA (Bilen, Harik).
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Źródło:
Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2024 Mar 01; Vol. 148 (3), pp. 310-317.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma*/genetics
Adenocarcinoma*/pathology
Carrier Proteins*
Prostatic Neoplasms*/genetics
Prostatic Neoplasms*/pathology
Humans ; Male ; Androgen Antagonists ; Black or African American/genetics ; DNA Helicases ; Lymph Nodes/pathology ; Nuclear Proteins/genetics ; Pilot Projects ; Poly-ADP-Ribose Binding Proteins ; Receptors, Androgen/genetics ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Retrospective Studies ; RNA Helicases/metabolism ; RNA Recognition Motif Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cancer-Related Mutations in the Sam Domains of EphA2 Receptor and Ship2 Lipid Phosphatase: A Computational Study.
Autorzy:
Vincenzi M; Institute of Biostructures and Bioimaging, Via Pietro Castellino 111, 80131 Naples, Italy.
Mercurio FA; Institute of Biostructures and Bioimaging, Via Pietro Castellino 111, 80131 Naples, Italy.
Autiero I; Institute of Biostructures and Bioimaging, Via Pietro Castellino 111, 80131 Naples, Italy.
Leone M; Institute of Biostructures and Bioimaging, Via Pietro Castellino 111, 80131 Naples, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 27; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Receptor, EphA2*/chemistry
Neoplasms*
Sterile Alpha Motif ; Protein Binding ; Mutation ; Phosphoric Monoester Hydrolases/metabolism ; Lipids
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Autorzy:
Bashore FM; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Katis VL; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Du Y; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America.
Sikdar A; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Wang D; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America.
Bradshaw WJ; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Rygiel KA; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Leisner TM; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Chalk R; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Mishra S; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America.
Williams CA; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America.
Gileadi O; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Brennan PE; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Wiley JC; Sage Bionetworks, Seattle, WA, United States of America.
Gockley J; Sage Bionetworks, Seattle, WA, United States of America.
Cary GA; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, United States of America.
Carter GW; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, United States of America.
Young JE; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America.
Pearce KH; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Fu H; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America.
Axtman AD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
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Corporate Authors:
Emory-Sage-SGC TREAT-AD Center
Źródło:
PloS one [PLoS One] 2024 Feb 15; Vol. 19 (2), pp. e0293548. Date of Electronic Publication: 2024 Feb 15 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
src Homology Domains*
Protein-Tyrosine Kinases*/metabolism
Humans ; Immunoreceptor Tyrosine-Based Activation Motif ; Intracellular Signaling Peptides and Proteins/metabolism ; Syk Kinase/metabolism ; Phosphorylation ; Receptors, Fc/metabolism ; Enzyme Precursors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
LncRNA WWTR1-AS1 upregulates Notch3 through miR-136 to increase cancer cell stemness in cervical squamous cell carcinoma.
Autorzy:
Zhou X; Department of Obstetrics and Gynecology, Bishan hospital of Chongqing medical university, Bishan Hospital of Chongqing, No. 9 Shuangxing Avenue, Biquan Street, Bishan District, 402760, Chongqing City, P. R. China.
Li Z; Department of Obstetrics and Gynecology, Bishan hospital of Chongqing medical university, Bishan Hospital of Chongqing, No. 9 Shuangxing Avenue, Biquan Street, Bishan District, 402760, Chongqing City, P. R. China.
Li M; Department of Obstetrics and Gynecology, Bishan hospital of Chongqing medical university, Bishan Hospital of Chongqing, No. 9 Shuangxing Avenue, Biquan Street, Bishan District, 402760, Chongqing City, P. R. China. .
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Źródło:
BMC women's health [BMC Womens Health] 2024 Feb 08; Vol. 24 (1), pp. 104. Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Squamous Cell*/genetics
Carcinoma, Squamous Cell*/pathology
MicroRNAs*/genetics
RNA, Long Noncoding*/genetics
Uterine Cervical Neoplasms*/pathology
Female ; Humans ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; RNA, Antisense/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Functions of TRIM56 in Antiviral Innate Immunity and Tumorigenesis.
Autorzy:
Fu L; School of Basic Medicine, Qingdao University, Qingdao 266000, China.
Zhou X; School of Basic Medicine, Qingdao University, Qingdao 266000, China.
Jiao Q; School of Basic Medicine, Qingdao University, Qingdao 266000, China.
Chen X; School of Basic Medicine, Qingdao University, Qingdao 266000, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 06; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Carcinogenesis*
Tripartite Motif Proteins*/metabolism
Viruses*/metabolism
Humans ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1.
Autorzy:
Garcia-Garcia J; Department of Medical Biology, Autophagy Research Group, University of Tromsø -The Arctic University of Norway, Norway.
Berge AKM; Department of Medical Biology, Autophagy Research Group, University of Tromsø -The Arctic University of Norway, Norway.
Overå KS; Department of Medical Biology, Autophagy Research Group, University of Tromsø -The Arctic University of Norway, Norway.
Larsen KB; Department of Medical Biology, Autophagy Research Group, University of Tromsø -The Arctic University of Norway, Norway.
Bhujabal Z; Department of Medical Biology, Autophagy Research Group, University of Tromsø -The Arctic University of Norway, Norway.
Brech A; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Norway.
Abudu YP; Department of Medical Biology, Autophagy Research Group, University of Tromsø -The Arctic University of Norway, Norway.
Lamark T; Department of Medical Biology, Autophagy Research Group, University of Tromsø -The Arctic University of Norway, Norway.
Johansen T; Department of Medical Biology, Autophagy Research Group, University of Tromsø -The Arctic University of Norway, Norway.
Sjøttem E; Department of Medical Biology, Autophagy Research Group, University of Tromsø -The Arctic University of Norway, Norway.
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Źródło:
The FEBS journal [FEBS J] 2023 Feb; Vol. 290 (4), pp. 1096-1116. Date of Electronic Publication: 2022 Sep 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*/physiology
Mitochondria*/genetics
Mitochondria*/metabolism
Mitophagy*/physiology
Ubiquitin-Protein Ligases*/metabolism
Tripartite Motif Proteins*/metabolism
Humans ; DNA-Binding Proteins/metabolism ; HEK293 Cells ; Nuclear Proteins/metabolism ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Sequestosome-1 Protein/metabolism ; Ubiquitin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 33133

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