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Wyszukujesz frazę ""oxysterols"" wg kryterium: Temat


Tytuł :
Identification of Anti-Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Oxysterol Derivatives In Vitro.
Autorzy :
Ohashi H; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.; Department of Applied Biological Sciences, Tokyo University of Science, Noda 278-8510, Japan.
Wang F; MAX BioPharma, Inc., 2870 Colorado Avenue, Santa Monica, CA 90404, USA.
Stappenbeck F; MAX BioPharma, Inc., 2870 Colorado Avenue, Santa Monica, CA 90404, USA.
Tsuchimoto K; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Kobayashi C; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.; Department of Applied Biological Sciences, Tokyo University of Science, Noda 278-8510, Japan.
Saso W; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.; The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.; AIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Kataoka M; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Yamasaki M; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.; Department of Applied Biological Sciences, Tokyo University of Science, Noda 278-8510, Japan.
Kuramochi K; Department of Applied Biological Sciences, Tokyo University of Science, Noda 278-8510, Japan.
Muramatsu M; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Suzuki T; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Sureau C; Laboratoire de Virologie Moléculaire, Institut National de la Transfusion Sanguine, 75739 Paris, France.
Takeda M; Department of Virology III, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.
Wakita T; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Parhami F; MAX BioPharma, Inc., 2870 Colorado Avenue, Santa Monica, CA 90404, USA.
Watashi K; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.; Department of Applied Biological Sciences, Tokyo University of Science, Noda 278-8510, Japan.; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.; MIRAI, JST, Kawaguchi Center Building, 4-1-8 Honcho, Kawaguchi City, Saitama 332-0012, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 19; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Oxysterols/*chemistry
Oxysterols/*pharmacology
SARS-CoV-2/*drug effects
Administration, Oral ; Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/pharmacokinetics ; COVID-19/drug therapy ; Cell Survival/drug effects ; Chlorocebus aethiops ; Mice ; Nucleocapsid Proteins/drug effects ; Oxysterols/administration & dosage ; Oxysterols/pharmacokinetics ; SARS-CoV-2/genetics ; Vero Cells ; Viral Replication Compartments/drug effects ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Deep mining of oxysterols and cholestenoic acids in human plasma and cerebrospinal fluid: Quantification using isotope dilution mass spectrometry.
Autorzy :
Yutuc E; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea, SA2 8PP, Wales, UK.
Dickson AL; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea, SA2 8PP, Wales, UK.
Pacciarini M; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea, SA2 8PP, Wales, UK.
Griffiths L; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea, SA2 8PP, Wales, UK.
Baker PRS; Avanti Polar Lipids Inc, Alabaster, AL, USA.
Connell L; Avanti Polar Lipids Inc, Alabaster, AL, USA.
Öhman A; Department of Integrative Medical Biology, Umeå University, SE-901 87, Umeå, Sweden.
Forsgren L; Department of Clinical Science, Neurosciences, Umeå University, SE-901 85, Umeå, Sweden.
Trupp M; Department of Clinical Science, Neurosciences, Umeå University, SE-901 85, Umeå, Sweden.
Vilarinho S; Departments of Internal Medicine, Section of Digestive Diseases, and of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Khalil Y; Inborn Errors of Metabolism, Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Clayton PT; Inborn Errors of Metabolism, Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Sari S; Department of Pediatrics, Division of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey.
Dalgic B; Department of Pediatrics, Division of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey.
Höflinger P; Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Schöls L; Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Griffiths WJ; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea, SA2 8PP, Wales, UK. Electronic address: .
Wang Y; Swansea University Medical School, ILS1 Building, Singleton Park, Swansea, SA2 8PP, Wales, UK.
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Źródło :
Analytica chimica acta [Anal Chim Acta] 2021 Apr 15; Vol. 1154, pp. 338259. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Oxysterols*
Cholesterol ; Chromatography, Liquid ; Humans ; Mass Spectrometry ; Sterols
Czasopismo naukowe
Tytuł :
Successful treatment of infantile oxysterol 7α-hydroxylase deficiency with oral chenodeoxycholic acid.
Autorzy :
Tang YP; Department of Pediatrics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.; Department of Gastroenterology, Qilu Children's Hospital of Shandong University, Jinan, 250022, Shandong, China.
Gong JY; Department of Pediatrics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Setchell KDR; Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Zhang W; Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Zhao J; The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Wang JS; The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. .
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Źródło :
BMC gastroenterology [BMC Gastroenterol] 2021 Apr 13; Vol. 21 (1), pp. 163. Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Liver Diseases*
Liver Transplantation*
Oxysterols*
Adolescent ; Bile Acids and Salts ; Chenodeoxycholic Acid/therapeutic use ; Female ; Humans ; Infant ; Male
Czasopismo naukowe
Tytuł :
Quantitative analysis of oxysterols in zebrafish embryos by HPLC-MS/MS.
Autorzy :
Fanti F; University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment, 64100 TE, Italy.
Merola C; University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment, 64100 TE, Italy.
Vremere A; University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment, 64100 TE, Italy.
Oliva E; University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment, 64100 TE, Italy.
Perugini M; University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment, 64100 TE, Italy.
Amorena M; University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment, 64100 TE, Italy.
Compagnone D; University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment, 64100 TE, Italy.
Sergi M; University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment, 64100 TE, Italy. Electronic address: .
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Źródło :
Talanta [Talanta] 2020 Dec 01; Vol. 220, pp. 121393. Date of Electronic Publication: 2020 Jul 11.
Typ publikacji :
Journal Article
MeSH Terms :
Oxysterols*
Zebrafish*
Animals ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Molecular insight into neurodegeneration - Langmuir monolayer study on the influence of oxysterols on model myelin sheath.
Autorzy :
Chachaj-Brekiesz A; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland. Electronic address: .
Wnętrzak A; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.
Włodarska S; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.
Lipiec E; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.
Dynarowicz-Latka P; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2020 Sep; Vol. 202, pp. 105727. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Oxysterols*
Myelin Sheath/*physiology
Microscopy/methods ; Neurodegenerative Diseases ; Surface Properties
Czasopismo naukowe
Tytuł :
Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol.
Autorzy :
Abrams ME; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Johnson KA; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Perelman SS; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Microbiology, New York University School of Medicine, NY, NY, USA.
Zhang LS; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Endapally S; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mar KB; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Thompson BM; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
McDonald JG; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Schoggins JW; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Radhakrishnan A; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA. .
Alto NM; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA. .
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Źródło :
Nature microbiology [Nat Microbiol] 2020 Jul; Vol. 5 (7), pp. 929-942. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacteria/*immunology
Bacterial Infections/*immunology
Bacterial Infections/*microbiology
Cell Membrane/*metabolism
Cholesterol/*metabolism
Immunity, Innate/*drug effects
Oxysterols/*pharmacology
Bacterial Infections/drug therapy ; Cholesterol/chemistry ; Cytokines/metabolism ; Epithelial Cells/microbiology ; Humans ; Interferons/metabolism ; Listeria/drug effects ; Listeria/immunology ; Models, Molecular ; Molecular Conformation ; Molecular Structure ; Oxysterols/chemistry ; Oxysterols/metabolism ; Shigella/drug effects ; Shigella/immunology ; Sterol O-Acyltransferase/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Cholesterol in quarantine.
Autorzy :
Dang EV; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
Madhani HD; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.; Chan-Zuckerberg Biohub, San Francisco, CA, USA.
Vance RE; Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. .
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Źródło :
Nature immunology [Nat Immunol] 2020 Jul; Vol. 21 (7), pp. 716-717.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Bacterial Infections*
Oxysterols*
Cholesterol ; Humans ; Immunity, Innate ; Quarantine
Czasopismo naukowe
Tytuł :
Evaluation of oxysterol levels of patients with silicosis by LC-MS/MS method.
Autorzy :
Aksu N; Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey.
Samadi A; Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, 107, Reykjavik, Iceland.
Yalçınkaya A; Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Çetin T; Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey.
Eser B; Research and Development Center, University of Health Sciences, Ankara, Turkey.
Lay İ; Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Öziş TN; Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey.
Öztaş Y; Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Sabuncuoğlu S; Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2020 Apr; Vol. 467 (1-2), pp. 117-125. Date of Electronic Publication: 2020 Feb 27.
Typ publikacji :
Journal Article
MeSH Terms :
Oxysterols/*analysis
Silicosis/*blood
Silicosis/*urine
Adult ; Case-Control Studies ; Chromatography, Liquid ; Humans ; Ketocholesterols/blood ; Ketocholesterols/urine ; Lipid Peroxidation ; Lysophospholipids ; Male ; Middle Aged ; Oxysterols/blood ; Oxysterols/urine ; Sphingosine/analogs & derivatives ; Tandem Mass Spectrometry ; Turkey
Czasopismo naukowe
Tytuł :
Oxysterols of helminth parasites and pathogenesis of foodborne hepatic trematodiasis caused by Opisthorchis and Fasciola species.
Autorzy :
Vale N; Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo 228, 4050-313, Porto, Portugal. .; Department of Molecular Pathology and Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua Jorge Viterbo 228, Porto, Portugal. .; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Júlio Amaral de Carvalho 45, 4200-135, Porto, Portugal. .; i3S, Instituto de Investigação e Inovação em Saúde, University of Porto, Rua Alfredo Allen, 4200-135, Porto, Portugal. .
Gouveia MJ; Department of Molecular Pathology and Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua Jorge Viterbo 228, Porto, Portugal.; Center for the Study of Animal Science, CECA - ICETA, University of Porto, Praça Gomes Teixeira Apt 55142, 4051-401, Porto, Portugal.
Gärtner F; Department of Molecular Pathology and Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua Jorge Viterbo 228, Porto, Portugal.; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Júlio Amaral de Carvalho 45, 4200-135, Porto, Portugal.; i3S, Instituto de Investigação e Inovação em Saúde, University of Porto, Rua Alfredo Allen, 4200-135, Porto, Portugal.
Brindley PJ; Department of Microbiology, Immunology & Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine and Health Sciences, George Washington University, Washington, DC, 20052, USA.
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Źródło :
Parasitology research [Parasitol Res] 2020 May; Vol. 119 (5), pp. 1443-1453. Date of Electronic Publication: 2020 Mar 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Fasciola/*metabolism
Foodborne Diseases/*parasitology
Opisthorchis/*metabolism
Oxysterols/*metabolism
Trematode Infections/*parasitology
Animals ; Bile Duct Neoplasms/chemically induced ; Bile Duct Neoplasms/parasitology ; Carcinogenesis ; Cholangiocarcinoma/chemically induced ; Cholangiocarcinoma/parasitology ; Humans ; Oxysterols/toxicity
Czasopismo naukowe
Tytuł :
Urinary and serum oxysterols in children: developmental pattern and potential biomarker for pediatric liver disease.
Autorzy :
Takaki Y; Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Mizuochi T; Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan. .
Takei H; Junshin Clinic Bile Acid Institute, Meguro-ku, Tokyo, Japan.
Eda K; Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Konishi KI; Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Ishihara J; Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Kinoshita M; Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Hashizume N; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Yamashita Y; Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Nittono H; Junshin Clinic Bile Acid Institute, Meguro-ku, Tokyo, Japan.
Kimura A; Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
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Źródło :
Scientific reports [Sci Rep] 2020 Apr 21; Vol. 10 (1), pp. 6752. Date of Electronic Publication: 2020 Apr 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oxysterols*/blood
Oxysterols*/urine
Biliary Atresia/*diagnosis
Choledochal Cyst/*diagnosis
Cholestasis, Intrahepatic/*diagnosis
Hepatitis, Autoimmune/*diagnosis
Liver Failure, Acute/*diagnosis
Adolescent ; Adult ; Age Factors ; Biliary Atresia/blood ; Biliary Atresia/pathology ; Biliary Atresia/urine ; Biomarkers/blood ; Biomarkers/urine ; Case-Control Studies ; Child ; Child, Preschool ; Choledochal Cyst/blood ; Choledochal Cyst/pathology ; Choledochal Cyst/urine ; Cholestasis, Intrahepatic/blood ; Cholestasis, Intrahepatic/pathology ; Cholestasis, Intrahepatic/urine ; Female ; Hepatitis, Autoimmune/blood ; Hepatitis, Autoimmune/pathology ; Hepatitis, Autoimmune/urine ; Humans ; Infant ; Infant, Newborn ; Liver/metabolism ; Liver/pathology ; Liver Failure, Acute/blood ; Liver Failure, Acute/pathology ; Liver Failure, Acute/urine ; Male ; Middle Aged ; Spectrometry, Mass, Electrospray Ionization
Czasopismo naukowe
Tytuł :
Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal N -Methyl-d-Aspartate Receptors, Long-Term Potentiation, and Learning.
Autorzy :
Izumi Y; Department of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (Y.I., S.J.M., C.F.Z.); and Sage Therapeutics, Cambridge, Massachusetts (J.J.D.).
Mennerick SJ; Department of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (Y.I., S.J.M., C.F.Z.); and Sage Therapeutics, Cambridge, Massachusetts (J.J.D.).
Doherty JJ; Department of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (Y.I., S.J.M., C.F.Z.); and Sage Therapeutics, Cambridge, Massachusetts (J.J.D.).
Zorumski CF; Department of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (Y.I., S.J.M., C.F.Z.); and Sage Therapeutics, Cambridge, Massachusetts (J.J.D.) .
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Apr; Vol. 377 (1), pp. 181-188. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Learning*
Long-Term Potentiation*
Ethanol/*pharmacology
Hippocampus/*drug effects
Oxysterols/*pharmacology
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Central Nervous System Depressants/pharmacology ; Drug Interactions ; Hippocampus/metabolism ; Hippocampus/physiology ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Cholestenoic acid analogues as inverse agonists of the liver X receptors.
Autorzy :
Alvarez LD; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, UMYMFOR, Buenos Aires, Argentina.
Dansey MV; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, UMYMFOR, Buenos Aires, Argentina.
Ogara MF; CONICET-Universidad de Buenos Aires, IFIBYNE, Buenos Aires, Argentina.
Peña CI; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, UMYMFOR, Buenos Aires, Argentina.
Houtman R; Pamgene International BV, 5211 HH Den Bosch, The Netherlands.
Veleiro AS; CONICET-Universidad de Buenos Aires, UMYMFOR, Buenos Aires, Argentina.
Pecci A; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, IFIBYNE, Buenos Aires, Argentina.
Burton G; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, UMYMFOR, Buenos Aires, Argentina. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2020 May; Vol. 199, pp. 105585. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cholestenes/*pharmacology
Cholesterol/*metabolism
Liver X Receptors/*chemistry
Oxysterols/*metabolism
Cholestenes/chemistry ; Cholesterol/genetics ; Gene Expression Regulation/drug effects ; Humans ; Ligands ; Lipid Metabolism ; Liver X Receptors/genetics ; Liver X Receptors/ultrastructure ; Microarray Analysis ; Molecular Conformation ; Molecular Dynamics Simulation ; Nuclear Magnetic Resonance, Biomolecular ; Oxysterols/chemistry ; Protein Binding/drug effects ; Protein Conformation ; Signal Transduction/drug effects ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Effect of selected B-ring-substituted oxysterols on artificial model erythrocyte membrane and isolated red blood cells.
Autorzy :
Targosz-Korecka M; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.
Wnętrzak A; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.
Chachaj-Brekiesz A; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.
Gonet-Surówka A; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.
Kubisiak A; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.
Filiczkowska A; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.
Szymoński M; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.
Dynarowicz-Latka P; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2020 Feb 01; Vol. 1862 (2), pp. 183067. Date of Electronic Publication: 2019 Oct 18.
Typ publikacji :
Journal Article
MeSH Terms :
Erythrocyte Membrane/*drug effects
Erythrocytes/*drug effects
Oxysterols/*pharmacology
Cell Shape/drug effects ; Cells, Cultured ; Elasticity/drug effects ; Erythrocyte Membrane/chemistry ; Humans ; Hydroxycholesterols/pharmacology ; Ketocholesterols/pharmacology ; Membrane Fluidity/drug effects ; Membranes, Artificial ; Oxysterols/chemistry ; Phosphatidylcholines
Czasopismo naukowe
Tytuł :
Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols.
Autorzy :
Sagimori I; Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Yoshioka H; Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Hashimoto Y; Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Ohgane K; Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Feb 01; Vol. 28 (3), pp. 115298. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hydroxymethylglutaryl CoA Reductases/*metabolism
Lanosterol/*metabolism
Oxysterols/*metabolism
HEK293 Cells ; Humans ; Lanosterol/pharmacology ; Molecular Structure ; Oxysterols/pharmacology ; Sterol Regulatory Element Binding Proteins/antagonists & inhibitors ; Sterol Regulatory Element Binding Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Oxysterols and sterols: From lipidomics to food sciences.
Autorzy :
Rodriguez-Estrada MT; Dipartimento di Scienze e Tecnologie Agro-Alimentari, Alma Mater Studiorum - Universita' di Bologna, Viale Fanin 40 (4o. piano, Ala Ovest), 40127 Bologna, Italy. Electronic address: .
Cardenia V; Department of Agricultural, Forest and Food Sciences, University of Turin, Largo Paolo Braccini 2, 10095 Grugliasco TO, Italy. Electronic address: .
Poirot M; Cancer Research Center of Toulouse, team 'Cholesterol metabolism and therapeutic innovations' UMR 1037 Inserm-University of Toulouse III, Toulouse, France. Electronic address: .
Iuliano L; UOC of Internal Medicine, Sapienza University of Rome and ICOT Hospital, Latina, & Vascular Biology & Mass Spectrometry Laboratory, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome and ICOT Hospital, Latina, Italy. Electronic address: .
Lizard G; University Bourgogne Franche-Comté (UBFC) / Inserm, Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism', EA 7270, 21000 Dijon, France. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2020 Feb; Vol. 196, pp. 105515. Date of Electronic Publication: 2019 Oct 28.
Typ publikacji :
Congress; Editorial
MeSH Terms :
Food Technology*/methods
Food Technology*/trends
Lipidomics*/methods
Lipidomics*/trends
Oxysterols/*pharmacology
Sterols/*pharmacology
Biomedical Research/trends ; Congresses as Topic ; Cooperative Behavior ; Humans ; Internationality ; Italy ; Oxysterols/chemistry ; Oxysterols/metabolism ; Sterols/chemistry ; Sterols/metabolism
Opinia redakcyjna
Tytuł :
Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis.
Autorzy :
Varaksa T; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Bukhdruker S; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Research Center Jülich, Jülich, Germany; JuStruct: Jülich Center for Structural Biology, Research Center Jülich, Jülich, Germany; ESRF-The European Synchrotron, Grenoble, France.
Grabovec I; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Marin E; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia.
Kavaleuski A; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Gusach A; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia.
Kovalev K; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia.
Maslov I; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia.
Luginina A; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia.
Zabelskii D; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Research Center Jülich, Jülich, Germany; JuStruct: Jülich Center for Structural Biology, Research Center Jülich, Jülich, Germany.
Astashkin R; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia.
Shevtsov M; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia.
Smolskaya S; Sechenov First Moscow State Medical University, Moscow, Russia.
Kavaleuskaya A; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Shabunya P; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Baranovsky A; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Dolgopalets V; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Charnou Y; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Savachka A; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Litvinovskaya R; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Hurski A; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Shevchenko E; MT-Medicals LLC, Moscow, Russia.
Rogachev A; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia; Joint Institute for Nuclear Research, Dubna, Russia.
Mishin A; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia.
Gordeliy V; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Research Center Jülich, Jülich, Germany; JuStruct: Jülich Center for Structural Biology, Research Center Jülich, Jülich, Germany; Institute of Crystallography, University of Aachen (RWTH), Aachen, Germany.
Gabrielian A; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Hurt DE; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Nikonenko B; Central Institute for Tuberculosis, Moscow, Russia.
Majorov K; Central Institute for Tuberculosis, Moscow, Russia.
Apt A; Central Institute for Tuberculosis, Moscow, Russia.
Rosenthal A; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Gilep A; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus; Institute of Biomedical Chemistry, Moscow, Russia; MT-Medicals LLC, Moscow, Russia.
Borshchevskiy V; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Research Center Jülich, Jülich, Germany; JuStruct: Jülich Center for Structural Biology, Research Center Jülich, Jülich, Germany. Electronic address: .
Strushkevich N; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus; Skolkovo Institute of Science and Technology, Moscow, Russia. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Feb 19; Vol. 433 (4), pp. 166763. Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Energy Metabolism*
Host-Pathogen Interactions*/immunology
Mycobacterium tuberculosis/*immunology
Tuberculosis/*immunology
Tuberculosis/*metabolism
3-Hydroxysteroid Dehydrogenases/chemistry ; 3-Hydroxysteroid Dehydrogenases/metabolism ; Catalysis ; Cytochrome P-450 Enzyme System/chemistry ; Cytochrome P-450 Enzyme System/metabolism ; Enzyme Activation ; Humans ; Immunity ; Isoenzymes ; Models, Molecular ; Oxysterols/chemistry ; Oxysterols/metabolism ; Recombinant Proteins ; Structure-Activity Relationship ; Tuberculosis/microbiology
Czasopismo naukowe
Tytuł :
Bioactive lipids in inflammatory bowel diseases - From pathophysiological alterations to therapeutic opportunities.
Autorzy :
Alhouayek M; Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Université catholique de Louvain, 1200 Bruxelles, Belgium. Electronic address: .
Ameraoui H; Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Université catholique de Louvain, 1200 Bruxelles, Belgium.
Muccioli GG; Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Université catholique de Louvain, 1200 Bruxelles, Belgium. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2021 Feb; Vol. 1866 (2), pp. 158854. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Colitis, Ulcerative/*immunology
Crohn Disease/*immunology
Gastrointestinal Agents/*pharmacology
Intestinal Mucosa/*pathology
Lipid Metabolism/*immunology
Adaptive Immunity/drug effects ; Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/metabolism ; Colitis, Ulcerative/pathology ; Crohn Disease/drug therapy ; Crohn Disease/metabolism ; Crohn Disease/pathology ; Disease Models, Animal ; Drug Therapy, Combination/methods ; Endocannabinoids/immunology ; Endocannabinoids/metabolism ; Fatty Acids/immunology ; Fatty Acids/metabolism ; Gastrointestinal Agents/therapeutic use ; Humans ; Immunity, Innate/drug effects ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Intestinal Mucosa/immunology ; Lipid Metabolism/drug effects ; Lysophospholipids/immunology ; Lysophospholipids/metabolism ; Oxysterols/immunology ; Oxysterols/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
A Comprehensive Review on Oxysterols and Related Diseases.
Autorzy :
Samadi A; Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland.
Sabuncuoglu S; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Samadi M; Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Isikhan SY; Vocational Higher School of Social Sciences, Hacettepe University, Ankara, Turkey.
Chirumbolo S; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Peana M; Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy.
Lay I; Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Yalcinkaya A; Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Bjørklund G; Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway.
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Źródło :
Current medicinal chemistry [Curr Med Chem] 2021; Vol. 28 (1), pp. 110-136.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Disease*
Oxysterols/*chemistry
Oxysterols/*metabolism
Cholesterol ; Humans ; Oxidation-Reduction
Czasopismo naukowe

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