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Tytuł:
PAK1-Dependent Regulation of Microtubule Organization and Spindle Migration Is Essential for the Metaphase I-Metaphase II Transition in Porcine Oocytes.
Autorzy:
Peng L; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
He Y; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Wang W; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Dai J; Key Laboratory of Livestock and Poultry Resources (Pig) Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.
Li Q; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Ju S; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
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Źródło:
Biomolecules [Biomolecules] 2024 Feb 17; Vol. 14 (2). Date of Electronic Publication: 2024 Feb 17.
Typ publikacji:
Journal Article
MeSH Terms:
p21-Activated Kinases*/metabolism
Spindle Apparatus*/metabolism
Animals ; Cell Cycle Proteins/metabolism ; Metaphase ; Microtubules/metabolism ; Oocytes/metabolism ; Swine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A missense variant at the RAC1-PAK1 binding site of RAC1 inactivates downstream signaling in VACTERL association.
Autorzy:
Seyama R; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.; Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Nishikawa M; Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center, 713-8 Kamiya, Kasugai, Aichi, 480-0392, Japan.; Department of Biological Sciences, Nagoya University, Nagoya, Japan.
Uchiyama Y; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.; Department of Rare Disease Genomics, Yokohama City University Hospital, Yokohama, Japan.
Hamada K; Department of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yamamoto Y; Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Takeda M; Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Ochi T; Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Kishi M; Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Suzuki T; Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, Tokyo, Japan.; Department of Obstetrics and Gynecology, Keiai Hospital, Saitama, Japan.
Hamanaka K; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.
Fujita A; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.
Tsuchida N; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.; Department of Rare Disease Genomics, Yokohama City University Hospital, Yokohama, Japan.
Koshimizu E; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.
Misawa K; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.; RIKEN Center for Advanced Intelligence Project, Tokyo, Japan.
Miyatake S; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.; Department of Clinical Genetics, Yokohama City University Hospital, Yokohama, Japan.
Mizuguchi T; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.
Makino S; Department of Obstetrics and Gynecology, Juntendo University Urayasu Hospital, Urayasu, Japan.
Yao T; Department of Human Pathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Ito H; Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center, 713-8 Kamiya, Kasugai, Aichi, 480-0392, Japan.
Itakura A; Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Ogata K; Department of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Nagata KI; Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center, 713-8 Kamiya, Kasugai, Aichi, 480-0392, Japan. .; Department of Neurochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Nagoya, Japan, 466-8550. .
Matsumoto N; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 16; Vol. 13 (1), pp. 9789. Date of Electronic Publication: 2023 Jun 16.
Typ publikacji:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
p21-Activated Kinases*/genetics
p21-Activated Kinases*/metabolism
Vena Cava, Superior*/metabolism
Humans ; Male ; Binding Sites ; Hedgehog Proteins/metabolism ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism ; Infant, Newborn
SCR Disease Name:
VACTERL association
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Circular RNA 0001789 sponges miR-140-3p and regulates PAK2 to promote the progression of gastric cancer.
Autorzy:
You J; Department of Gastrointestinal Oncology Surgery, Cancer Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361001, China.; The Third Clinical Medical College, Fujian Medical University, Xiamen, Fujian, 361001, China.
Chen Y; Department of Gastrointestinal Oncology Surgery, Cancer Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361001, China.; The Third Clinical Medical College, Fujian Medical University, Xiamen, Fujian, 361001, China.
Chen D; Department of Gastrointestinal Oncology Surgery, Cancer Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361001, China.; The Third Clinical Medical College, Fujian Medical University, Xiamen, Fujian, 361001, China.
Li Y; Department of Gastrointestinal Oncology Surgery, Cancer Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361001, China.; The Third Clinical Medical College, Fujian Medical University, Xiamen, Fujian, 361001, China.
Wang T; Department of Gastrointestinal Oncology Surgery, Cancer Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361001, China.; The Third Clinical Medical College, Fujian Medical University, Xiamen, Fujian, 361001, China.
Zhu J; Department of Gastrointestinal Oncology Surgery, Cancer Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361001, China.; The Third Clinical Medical College, Fujian Medical University, Xiamen, Fujian, 361001, China.
Hong Q; Department of Gastrointestinal Oncology Surgery, Cancer Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361001, China. .; The Third Clinical Medical College, Fujian Medical University, Xiamen, Fujian, 361001, China. .
Li Q; National Institute of Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, 361100, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Feb 05; Vol. 21 (1), pp. 83. Date of Electronic Publication: 2023 Feb 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
MicroRNAs*/genetics
p21-Activated Kinases*/genetics
RNA, Circular*/genetics
Stomach Neoplasms*/genetics
Animals ; Humans ; Mice ; Biological Assay ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PAK1 Is Involved in the Spindle Assembly during the First Meiotic Division in Porcine Oocytes.
Autorzy:
Peng L; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
He Y; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Wang W; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Chu Y; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Lin Q; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Rui R; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Li Q; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Ju S; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 06; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
p21-Activated Kinases*/genetics
p21-Activated Kinases*/metabolism
Spindle Apparatus*/metabolism
Swine ; Animals ; Oocytes ; Cell Cycle Proteins/metabolism ; Meiosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4).
Autorzy:
Ha BH; The Department of Pharmacology, Yale University, 333 Cedar St., New Haven, CT, 06520, USA.
Yigit S; The Department of Pharmacology, Yale University, 333 Cedar St., New Haven, CT, 06520, USA.
Natarajan N; The Department of Pharmacology, Yale University, 333 Cedar St., New Haven, CT, 06520, USA.
Morse EM; The Department of Cell Biology, Yale University, 333 Cedar St., New Haven, CT, 06520, USA.
Calderwood DA; The Department of Pharmacology, Yale University, 333 Cedar St., New Haven, CT, 06520, USA. .; The Department of Cell Biology, Yale University, 333 Cedar St., New Haven, CT, 06520, USA. .
Boggon TJ; The Department of Pharmacology, Yale University, 333 Cedar St., New Haven, CT, 06520, USA. .; The Department of Molecular Biophysics and Biochemistry, Yale University, 333 Cedar St., New Haven, CT, 06520, USA. .
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Źródło:
Communications biology [Commun Biol] 2022 Nov 17; Vol. 5 (1), pp. 1257. Date of Electronic Publication: 2022 Nov 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
p21-Activated Kinases*/genetics
p21-Activated Kinases*/metabolism
Platelet Glycoprotein GPIb-IX Complex*
Amino Acid Sequence ; Integrins/genetics ; Integrins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PAK in Pancreatic Cancer-Associated Vasculature: Implications for Therapeutic Response.
Autorzy:
Ansardamavandi A; Department of Surgery, Austin Precinct, The University of Melbourne, 145 Studley Rd, Heidelberg, VIC 3084, Australia.
Nikfarjam M; Department of Surgery, Austin Precinct, The University of Melbourne, 145 Studley Rd, Heidelberg, VIC 3084, Australia.; Department of Hepatopancreatic-Biliary Surgery, Austin Health, 145 Studley Rd, Heidelberg, VIC 3084, Australia.
He H; Department of Surgery, Austin Precinct, The University of Melbourne, 145 Studley Rd, Heidelberg, VIC 3084, Australia.
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Źródło:
Cells [Cells] 2023 Nov 23; Vol. 12 (23). Date of Electronic Publication: 2023 Nov 23.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Pancreatic Neoplasms*/drug therapy
Humans ; Pancreas/pathology ; Cell Transformation, Neoplastic ; p21-Activated Kinases ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Protein-Protein Interaction Analysis Suggests a Wide Range of New Functions for the p21-Activated Kinase (PAK) Ste20.
Autorzy:
Joshua IM; Division of Biosciences, Brunel University London, Uxbridge UB8 3PH, UK.
Lin M; Institute of Biochemistry, Kiel University, 24118 Kiel, Germany.
Mardjuki A; Division of Biosciences, Brunel University London, Uxbridge UB8 3PH, UK.
Mazzola A; Division of Biosciences, Brunel University London, Uxbridge UB8 3PH, UK.; Department of Biopathology and Medical and Forensic Biotechnologies, University of Palermo, 90133 Palermo, Italy.
Höfken T; Division of Biosciences, Brunel University London, Uxbridge UB8 3PH, UK.; Institute of Biochemistry, Kiel University, 24118 Kiel, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 02; Vol. 24 (21). Date of Electronic Publication: 2023 Nov 02.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Serine-Threonine Kinases*/metabolism
Saccharomyces cerevisiae Proteins*/metabolism
Humans ; MAP Kinase Kinase Kinases/metabolism ; p21-Activated Kinases/genetics ; p21-Activated Kinases/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Inhibitory Mechanism of 7 H -Pyrrolo[2,3-d]pyrimidine Derivatives as Inhibitors of P21-Activated Kinase 4 through Molecular Dynamics Simulation.
Autorzy:
Du J; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130023, China.
Wang S; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130023, China.
Zhang X; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130023, China.
Liu C; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130023, China.
Zhang Y; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130023, China.
Zhang H; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130023, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jan 03; Vol. 28 (1). Date of Electronic Publication: 2023 Jan 03.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Dynamics Simulation*
p21-Activated Kinases*
Pyrimidines/pharmacology ; Pyrimidines/chemistry ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Molecular Docking Simulation ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4- d ]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice.
Autorzy:
Mao Y; Department of Biochemistry and Research Institute for Endocrine Sciences, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
Lee E; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea.
Yang X; School of Pharmacy, Jeonbuk National University, Jeonju, Republic of Korea.
Bae EJ; School of Pharmacy, Jeonbuk National University, Jeonju, Republic of Korea.
Jeon R; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea.
Park BH; Department of Biochemistry and Research Institute for Endocrine Sciences, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 2133-2146.
Typ publikacji:
Journal Article
MeSH Terms:
Reperfusion Injury*/drug therapy
Reperfusion Injury*/metabolism
p21-Activated Kinases*/metabolism
Animals ; Apoptosis ; Liver/metabolism ; Mice ; Protein Serine-Threonine Kinases ; Pyrimidines/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder.
Autorzy:
Fuchs C; Department of Biomedical and Neuromotor Science, University of Bologna, Bologna, Italy.
Cosentino L; Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Urbinati C; Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Talamo MC; Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Medici G; Department of Biomedical and Neuromotor Science, University of Bologna, Bologna, Italy.
Quattrini MC; Core Facilities, Istituto Superiore di Sanità, Rome, Italy.
Mottolese N; Department of Biomedical and Neuromotor Science, University of Bologna, Bologna, Italy.
Pietraforte D; Core Facilities, Istituto Superiore di Sanità, Rome, Italy.
Fuso A; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Ciani E; Department of Biomedical and Neuromotor Science, University of Bologna, Bologna, Italy.
De Filippis B; Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2022 Nov; Vol. 28 (11), pp. 1718-1732. Date of Electronic Publication: 2022 Aug 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Spasms, Infantile*
p21-Activated Kinases*
Animals ; Disease Models, Animal ; Disks Large Homolog 4 Protein ; Epileptic Syndromes ; Female ; Glucose ; Male ; Mice ; Mice, Knockout ; Protein Serine-Threonine Kinases/genetics ; Pyridones ; Pyrimidines ; Serine ; Threonine/therapeutic use
SCR Disease Name:
CDKL5 deficiency disorder
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Different Transcriptome Features of Peripheral Blood Mononuclear Cells in Non-Emphysematous Chronic Obstructive Pulmonary Disease.
Autorzy:
Imamoto T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Kawasaki T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Sato H; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Tatsumi K; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Ishii D; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Yoshioka K; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Hasegawa Y; Department of Applied Genomics, Kazusa DNA Research Institute, Chiba 292-0818, Japan.
Ohara O; Department of Applied Genomics, Kazusa DNA Research Institute, Chiba 292-0818, Japan.
Suzuki T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.; Synergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University, Chiba 260-8670, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 20; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
Pulmonary Disease, Chronic Obstructive*/genetics
Asthma*
Humans ; Transcriptome ; Leukocytes, Mononuclear ; Genes, Regulator ; p21-Activated Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development.
Autorzy:
Yamada S; Laboratory for Molecular Neurobiology, Faculty of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan.
Mizukoshi T; Laboratory for Molecular Neurobiology, Faculty of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan.
Tokunaga A; Division of Laboratory Animal Resources, Life Science Research Laboratory, University of Fukui, Eiheiji, Fukui, Japan.
Sakakibara SI; Laboratory for Molecular Neurobiology, Faculty of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan.
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Źródło:
PLoS genetics [PLoS Genet] 2022 Oct 27; Vol. 18 (10), pp. e1010438. Date of Electronic Publication: 2022 Oct 27 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Actins*/genetics
Actins*/metabolism
Neurogenesis*
p21-Activated Kinases*/metabolism
Adaptor Proteins, Signal Transducing*/metabolism
Animals ; Mice ; Cytoskeleton/metabolism ; Phosphorylation ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting of p21-Activated Kinase 4 Radiosensitizes Glioblastoma Cells via Impaired DNA Repair.
Autorzy:
Blankenstein LJ; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, PF 41, 01307 Dresden, Germany.; National Center for Tumor Diseases, Partner Site Dresden: German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Cordes N; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, PF 41, 01307 Dresden, Germany.; National Center for Tumor Diseases, Partner Site Dresden: German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.; Department of Radiotherapy and Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, PF 50, 01307 Dresden, Germany.; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology-OncoRay, Bautzner Landstr. 400, 01328 Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69192 Heidelberg, Germany.
Kunz-Schughart LA; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, PF 41, 01307 Dresden, Germany.; National Center for Tumor Diseases, Partner Site Dresden: German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Vehlow A; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, PF 41, 01307 Dresden, Germany.; National Center for Tumor Diseases, Partner Site Dresden: German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69192 Heidelberg, Germany.
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Źródło:
Cells [Cells] 2022 Jul 06; Vol. 11 (14). Date of Electronic Publication: 2022 Jul 06.
Typ publikacji:
Journal Article
MeSH Terms:
Glioblastoma*/genetics
Glioblastoma*/metabolism
Glioblastoma*/radiotherapy
p21-Activated Kinases*/genetics
p21-Activated Kinases*/metabolism
DNA Breaks, Double-Stranded/radiation effects ; DNA Repair/radiation effects ; Humans ; RNA, Small Interfering
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis.
Autorzy:
Xue ST; Department of Thoracic Surgery, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, 350001, Fujian, China.; Fujian Key Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, No. 29 Xinquan Road, Fuzhou, 350001, Fujian, China.
Zheng B; Department of Thoracic Surgery, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, 350001, Fujian, China.; Fujian Key Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, No. 29 Xinquan Road, Fuzhou, 350001, Fujian, China.
Cao SQ; Department of Thoracic Surgery, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, 350001, Fujian, China.; Fujian Key Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, No. 29 Xinquan Road, Fuzhou, 350001, Fujian, China.
Ding JC; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, 361102, Fujian, China.; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, 361102, Fujian, China.
Hu GS; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, 361102, Fujian, China.; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, 361102, Fujian, China.
Liu W; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, 361102, Fujian, China. .; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, 361102, Fujian, China. .
Chen C; Department of Thoracic Surgery, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, 350001, Fujian, China. .; Fujian Key Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, No. 29 Xinquan Road, Fuzhou, 350001, Fujian, China. .
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Źródło:
Molecular cancer [Mol Cancer] 2022 Mar 07; Vol. 21 (1), pp. 69. Date of Electronic Publication: 2022 Mar 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Esophageal Neoplasms*/pathology
Esophageal Squamous Cell Carcinoma*/pathology
MicroRNAs*/genetics
MicroRNAs*/metabolism
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
p21-Activated Kinases*/genetics
p21-Activated Kinases*/metabolism
Animals ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Humans ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PAK1 and Therapy Resistance in Melanoma.
Autorzy:
Kichina JV; Department of Immunology, Roswell Park Comprehensive Cancer Center, Elm & Carlton St., Buffalo, NY 14263, USA.
Maslov A; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Elm & Carlton St., Buffalo, NY 14263, USA.
Kandel ES; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Elm & Carlton St., Buffalo, NY 14263, USA.
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Źródło:
Cells [Cells] 2023 Sep 28; Vol. 12 (19). Date of Electronic Publication: 2023 Sep 28.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Melanoma*/drug therapy
Melanoma*/metabolism
Skin Neoplasms*/drug therapy
Skin Neoplasms*/metabolism
Humans ; p21-Activated Kinases/metabolism ; Signal Transduction ; Cell Line, Tumor ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ATRA sensitized the response of hepatocellular carcinoma to Sorafenib by downregulation of p21-activated kinase 1.
Autorzy:
Wang K; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, People's Republic of China.
Qiu X; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.; Zhejiang University School of Medicine, Hangzhou, 310058, People's Republic of China.
Zhang Z; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.; Zhejiang University School of Medicine, Hangzhou, 310058, People's Republic of China.
Xu H; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.; Zhejiang University School of Medicine, Hangzhou, 310058, People's Republic of China.
Tan Y; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.; Zhejiang University School of Medicine, Hangzhou, 310058, People's Republic of China.
Su R; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.; Zhejiang University School of Medicine, Hangzhou, 310058, People's Republic of China.
Gao F; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.; Zhejiang University School of Medicine, Hangzhou, 310058, People's Republic of China.
Zhuo J; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.
Li W; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.
Lian Z; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.
He H; Department of Surgery, University of Melbourne, Austin Health, Heidelberg, VIC, 3084, Australia. .
Xu X; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, People's Republic of China. .; Zhejiang University School of Medicine, Hangzhou, 310058, People's Republic of China. .; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, People's Republic of China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2023 Aug 03; Vol. 21 (1), pp. 193. Date of Electronic Publication: 2023 Aug 03.
Typ publikacji:
Video-Audio Media; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/pathology
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Humans ; Sorafenib/pharmacology ; p21-Activated Kinases/metabolism ; Down-Regulation ; Cell Line, Tumor ; Tretinoin/pharmacology ; Apoptosis ; Cell Proliferation ; Drug Resistance, Neoplasm
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Study on the Effect of the Substituent against PAK4 Inhibition Using In Silico Methods.
Autorzy:
Yoon HR; Graduate School of New Drug Discovery and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
Chai CC; Pharos iBio Co., Ltd. #1408, 38 Heungan-daero 427, Dongan-gu, Anyang-si 14059, Korea.
Kim CH; Pharos iBio Co., Ltd. #1408, 38 Heungan-daero 427, Dongan-gu, Anyang-si 14059, Korea.
Kang NS; Graduate School of New Drug Discovery and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Mar 19; Vol. 23 (6). Date of Electronic Publication: 2022 Mar 19.
Typ publikacji:
Journal Article
MeSH Terms:
p21-Activated Kinases*/metabolism
Molecular Docking Simulation ; Static Electricity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
miR-425 regulates ovarian cancer proliferation, metastasis, and apoptosis by repressing PAK4 expression.
Autorzy:
Wang Y; Department of thoracic surgery, Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, China.; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.; Department of Gynecological Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Shao F; Department of thoracic surgery, Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, China.; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.; Department of Gynecological Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Chen L; Department of thoracic surgery, Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, China.; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.; Department of Gynecological Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
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Źródło:
Asia-Pacific journal of clinical oncology [Asia Pac J Clin Oncol] 2022 Feb; Vol. 18 (1), pp. 76-83. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji:
Journal Article
MeSH Terms:
MicroRNAs*/genetics
Ovarian Neoplasms*/genetics
p21-Activated Kinases*/genetics
Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Female ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Probiotic microbes: Are their anti-melanogenicity and longevity promoting activities closely linked through the major "pathogenic" kinase PAK1?
Autorzy:
Maruta H; PAK Research Center, Melbourne, Australia.
Ahn MR; Department of Food Science and Nutrition, Dong-A University, Busan, Korea.; Center for Silver-Targeted Biomaterials, Brain Busan 21 Plus Program, Graduate School, Dong-A University, Busan, Korea.
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Źródło:
Drug discoveries & therapeutics [Drug Discov Ther] 2022; Vol. 16 (1), pp. 43-46.
Typ publikacji:
Journal Article
MeSH Terms:
Melanins*/metabolism
Probiotics*/pharmacology
p21-Activated Kinases*
Animals ; Caenorhabditis elegans/metabolism ; Escherichia coli/metabolism ; Longevity ; Melanocytes/metabolism ; Monophenol Monooxygenase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Use of Nanomedicine to Target Signaling by the PAK Kinases for Disease Treatment.
Autorzy:
Wang Y; Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Minden A; Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
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Źródło:
Cells [Cells] 2021 Dec 17; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Nanomedicine*
Signal Transduction*
Neoplasms/*drug therapy
p21-Activated Kinases/*metabolism
Animals ; Disease Models, Animal ; Humans ; Nanoparticles/chemistry ; p21-Activated Kinases/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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