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Wyszukujesz frazę ""p38 Mitogen-Activated Protein Kinases"" wg kryterium: Temat


Tytuł :
p38 Mitogen-activated protein kinase modulates cisplatin resistance in Head and Neck Squamous Cell Carcinoma cells.
Autorzy :
Roy S; Molecular Stress and Stem Cell Biology Group, School of Biotechnology, KIIT, Bhubaneswar, Odisha 751024, India.
Roy S; Molecular Stress and Stem Cell Biology Group, School of Biotechnology, KIIT, Bhubaneswar, Odisha 751024, India.
Anuja K; Molecular Stress and Stem Cell Biology Group, School of Biotechnology, KIIT, Bhubaneswar, Odisha 751024, India.
Thakur S; Centre for Computational Biology and Bioinformatics, School of Life Sciences, Central University of Himachal Pradesh, Shahpur, Himachal Pradesh 176206, India.
Akhter Y; Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow, Uttar Pradesh 226025, India.
Padhi S; Molecular Stress and Stem Cell Biology Group, School of Biotechnology, KIIT, Bhubaneswar, Odisha 751024, India.
Banerjee B; Molecular Stress and Stem Cell Biology Group, School of Biotechnology, KIIT, Bhubaneswar, Odisha 751024, India. Electronic address: .
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Źródło :
Archives of oral biology [Arch Oral Biol] 2021 Feb; Vol. 122, pp. 104981. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Cisplatin/*pharmacology
Head and Neck Neoplasms/*enzymology
Squamous Cell Carcinoma of Head and Neck/*enzymology
p38 Mitogen-Activated Protein Kinases/*physiology
Cell Line, Tumor ; DNA Damage ; Head and Neck Neoplasms/drug therapy ; Humans ; Molecular Docking Simulation ; Neoplastic Stem Cells ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Endothelin-1 stimulates preadipocyte growth via the PKC, STAT3, AMPK, c-JUN, ERK, sphingosine kinase, and sphingomyelinase pathways.
Autorzy :
Siao AC; Department of Life Sciences, National Central University, Taoyuan, Taiwan.
Lin YY; Department of Life Sciences, National Central University, Taoyuan, Taiwan.; Department of Emergency, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.; National Defense Medical Center, Taipei, Taiwan.
Shih LJ; National Defense Medical Center, Taipei, Taiwan.; Medical Laboratory, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.
Tsuei YW; Department of Emergency, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.
Chuu CP; Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.
Kuo YC; Division of Gastroenterology, Landseed Hospital, Taoyuan, Taiwan.
Kao YH; Department of Life Sciences, National Central University, Taoyuan, Taiwan.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Nov 01; Vol. 319 (5), pp. C839-C857. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipocytes/*drug effects
Endothelin-1/*pharmacology
JNK Mitogen-Activated Protein Kinases/*genetics
Protein Kinase C/*genetics
STAT3 Transcription Factor/*genetics
p38 Mitogen-Activated Protein Kinases/*genetics
3T3-L1 Cells ; Adipocytes/cytology ; Adipocytes/metabolism ; Animals ; Butadienes/pharmacology ; Cell Differentiation ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Endothelin Receptor Antagonists/pharmacology ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Regulation ; Imidazoles/pharmacology ; JNK Mitogen-Activated Protein Kinases/metabolism ; Mice ; Nitriles/pharmacology ; Oligopeptides/pharmacology ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Piperidines/pharmacology ; Protein Kinase C/metabolism ; Pyridines/pharmacology ; Receptors, Endothelin/genetics ; Receptors, Endothelin/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Sphingomyelin Phosphodiesterase/genetics ; Sphingomyelin Phosphodiesterase/metabolism ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK.
Autorzy :
Uwada J; Division of Cellular Signal Transduction, Department of Biochemistry, Asahikawa Medical University, Asahikawa 078-8510, Japan. Electronic address: .
Nakazawa H; Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, Asahikawa 078-8510, Japan.
Mikami D; Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
Islam MS; Division of Cellular Signal Transduction, Department of Biochemistry, Asahikawa Medical University, Asahikawa 078-8510, Japan.
Muramatsu I; Department of Pharmacology, Kanazawa Medical University, Kanazawa 920-0293, Japan.
Taniguchi T; Division of Cellular Signal Transduction, Department of Biochemistry, Asahikawa Medical University, Asahikawa 078-8510, Japan; Department of Urology, Otaki Hospital, Fukui 910-0029, Japan.
Yazawa T; Division of Cellular Signal Transduction, Department of Biochemistry, Asahikawa Medical University, Asahikawa 078-8510, Japan.
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114297. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Isoxazoles/*pharmacology
Phenylurea Compounds/*pharmacology
Protein Kinase Inhibitors/*pharmacology
alpha7 Nicotinic Acetylcholine Receptor/*agonists
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Allosteric Regulation/drug effects ; Allosteric Regulation/physiology ; Animals ; Dose-Response Relationship, Drug ; Humans ; Isoxazoles/chemistry ; MCF-7 Cells ; Mice ; Phenylurea Compounds/chemistry ; Protein Kinase Inhibitors/chemistry ; alpha7 Nicotinic Acetylcholine Receptor/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Rosmarinic acid inhibits oxLDL-induced inflammasome activation under high-glucose conditions through downregulating the p38-FOXO1-TXNIP pathway.
Autorzy :
Nyandwi JB; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea; Department of Pharmacy, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Kigali 4285, Rwanda.
Ko YS; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea.
Jin H; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea.
Yun SP; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea.
Park SW; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea.
Kim HJ; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114246. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carrier Proteins/*metabolism
Cinnamates/*pharmacology
Depsides/*pharmacology
Forkhead Box Protein O1/*metabolism
Glucose/*toxicity
Inflammasomes/*metabolism
Lipoproteins, LDL/*toxicity
p38 Mitogen-Activated Protein Kinases/*metabolism
Antioxidants/pharmacology ; Carrier Proteins/antagonists & inhibitors ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Down-Regulation/drug effects ; Down-Regulation/physiology ; Forkhead Box Protein O1/antagonists & inhibitors ; Humans ; Inflammasomes/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Discovery of talmapimod analogues as polypharmacological anti-inflammatory agents.
Autorzy :
Liu W; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Hou C; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Li J; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.; Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei, China.
Ma X; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.; Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei, China.
Zhang Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.; Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei, China.
Hu M; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Huang Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 187-198.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Cyclooxygenase 2/*metabolism
NF-kappa B/*antagonists & inhibitors
Nitric Oxide Synthase Type II/*antagonists & inhibitors
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Male ; Mice ; Mice, Inbred ICR ; Molecular Structure ; NF-kappa B/metabolism ; Nitric Oxide Synthase Type II/metabolism ; RAW 264.7 Cells ; Signal Transduction/drug effects ; Structure-Activity Relationship ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
The role of MAP-kinase p38 in the m. soleus slow myosin mRNA transcription regulation during short-term functional unloading.
Autorzy :
Sharlo KA; Institute of Biomedical Problems, RAS, Moscow, 76A Khoroshevskoe Shosse, 123007, Russia. Electronic address: .
Mochalova EP; Institute of Biomedical Problems, RAS, Moscow, 76A Khoroshevskoe Shosse, 123007, Russia. Electronic address: .
Belova SP; Institute of Biomedical Problems, RAS, Moscow, 76A Khoroshevskoe Shosse, 123007, Russia. Electronic address: .
Lvova ID; Institute of Biomedical Problems, RAS, Moscow, 76A Khoroshevskoe Shosse, 123007, Russia. Electronic address: .
Nemirovskaya TL; Institute of Biomedical Problems, RAS, Moscow, 76A Khoroshevskoe Shosse, 123007, Russia. Electronic address: .
Shenkman BS; Institute of Biomedical Problems, RAS, Moscow, 76A Khoroshevskoe Shosse, 123007, Russia. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Nov 30; Vol. 695, pp. 108622. Date of Electronic Publication: 2020 Oct 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Signaling System*
Transcription, Genetic*
Cardiac Myosins/*biosynthesis
Muscle, Skeletal/*enzymology
Myosin Heavy Chains/*biosynthesis
RNA, Messenger/*biosynthesis
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; DNA-Binding Proteins/metabolism ; Male ; Nuclear Proteins/metabolism ; Rats ; Rats, Wistar ; Transcription Factors/metabolism ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Activation of p38 MAPK participates in the sulbactam-induced cerebral ischemic tolerance mediated by glial glutamate transporter-1 upregulation in rats.
Autorzy :
Xian XH; Department of Pathophysiology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, People's Republic of China.
Gao JX; Department of Pathophysiology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, People's Republic of China.
Qi J; Department of Pathophysiology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, People's Republic of China.
Fan SJ; Department of Pathophysiology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, People's Republic of China.
Zhang M; Department of Pathophysiology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, People's Republic of China. .; Neuroscience Research Center of Hebei Medical University, Shijiazhuang, People's Republic of China. .
Li WB; Department of Pathophysiology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, People's Republic of China. .; Neuroscience Research Center of Hebei Medical University, Shijiazhuang, People's Republic of China. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 26; Vol. 10 (1), pp. 20601. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Ischemia/*drug therapy
Excitatory Amino Acid Transporter 2/*metabolism
Neuroprotective Agents/*therapeutic use
Sulbactam/*therapeutic use
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; Enzyme Activation/drug effects ; Excitatory Amino Acid Transporter 2/analysis ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hippocampus/pathology ; Male ; Neuroprotective Agents/pharmacology ; Rats ; Rats, Wistar ; Sulbactam/pharmacology ; Up-Regulation/drug effects ; p38 Mitogen-Activated Protein Kinases/analysis
Czasopismo naukowe
Tytuł :
[Effects of combination of dihydroartemisinin and Huobahua on expression of p-p38 MAPK and ICAM-1 in mice with delayed-type hypersensitivity].
Autorzy :
Min-Xia Z; Institute of Chinese Pharmacology and Toxicology, Chongqing Academy of Chinese Materia Medica Chongqing 400065, China.
Wei DU; Institute of Chinese Pharmacology and Toxicology, Chongqing Academy of Chinese Materia Medica Chongqing 400065, China.
Heng-Hua LI; Institute of Chinese Pharmacology and Toxicology, Chongqing Academy of Chinese Materia Medica Chongqing 400065, China.
Jin-Ping L; Institute of Chinese Pharmacology and Toxicology, Chongqing Academy of Chinese Materia Medica Chongqing 400065, China.
Xiao-Li M; Institute of Chinese Pharmacology and Toxicology, Chongqing Academy of Chinese Materia Medica Chongqing 400065, China.
Ru-Xia TU; Institute of Chinese Pharmacology and Toxicology, Chongqing Academy of Chinese Materia Medica Chongqing 400065, China.
Li Z; Institute of Chinese Pharmacology and Toxicology, Chongqing Academy of Chinese Materia Medica Chongqing 400065, China.
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Źródło :
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2020 Nov; Vol. 45 (22), pp. 5561-5566.
Typ publikacji :
Journal Article
MeSH Terms :
Artemisinins*
p38 Mitogen-Activated Protein Kinases*/genetics
Animals ; Intercellular Adhesion Molecule-1/genetics ; Mice ; Monocytes
Czasopismo naukowe
Tytuł :
Combination of DN604 with gemcitabine led to cell apoptosis and cell motility inhibition via p38 MAPK signaling pathway in NSCLC.
Autorzy :
Wang X; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
Chen F; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, China. Electronic address: .
Gou S; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104234. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Carboplatin/*analogs & derivatives
Carcinoma, Non-Small-Cell Lung/*drug therapy
Deoxycytidine/*analogs & derivatives
Lung Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carboplatin/chemistry ; Carboplatin/pharmacology ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Deoxycytidine/chemistry ; Deoxycytidine/pharmacology ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ; Mice, Nude ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Signal Transduction/drug effects ; Structure-Activity Relationship ; Tumor Cells, Cultured ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
TLR2/4 promotes PGE 2 production to increase tissue damage in Escherichia coli-infected bovine endometrial explants via MyD88/p38 MAPK pathway.
Autorzy :
Li T; College of Veterinary Medicine, China Agricultural University, Beijing, China; Key Laboratory of Clinical Diagnosis and Treatment Techniques of Animal Disease for Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Hai L; Key Laboratory of Clinical Diagnosis and Treatment Techniques of Animal Disease for Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Liu B; Key Laboratory of Clinical Diagnosis and Treatment Techniques of Animal Disease for Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Mao W; Key Laboratory of Clinical Diagnosis and Treatment Techniques of Animal Disease for Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Liu K; Key Laboratory of Clinical Diagnosis and Treatment Techniques of Animal Disease for Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Yuan Shen; Key Laboratory of Clinical Diagnosis and Treatment Techniques of Animal Disease for Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Li Q; Key Laboratory of Clinical Diagnosis and Treatment Techniques of Animal Disease for Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Guo Y; Key Laboratory of Clinical Diagnosis and Treatment Techniques of Animal Disease for Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Jia Y; Key Laboratory of Clinical Diagnosis and Treatment Techniques of Animal Disease for Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Bao H; Key Laboratory of Clinical Diagnosis and Treatment Techniques of Animal Disease for Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Cao J; Key Laboratory of Clinical Diagnosis and Treatment Techniques of Animal Disease for Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China. Electronic address: .
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Źródło :
Theriogenology [Theriogenology] 2020 Aug; Vol. 152, pp. 129-138. Date of Electronic Publication: 2020 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Endometrium/*microbiology
Escherichia coli/*metabolism
Myeloid Differentiation Factor 88/*metabolism
Toll-Like Receptor 2/*metabolism
Toll-Like Receptor 4/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Cattle ; Dinoprostone/genetics ; Dinoprostone/metabolism ; Escherichia coli/classification ; Female ; Gene Expression ; Gene Expression Regulation/drug effects ; Heterocyclic Compounds, 2-Ring/administration & dosage ; Heterocyclic Compounds, 2-Ring/pharmacology ; Imidazoles/administration & dosage ; Imidazoles/pharmacology ; Lactones/administration & dosage ; Lactones/pharmacology ; Lipopeptides/administration & dosage ; Lipopeptides/pharmacology ; Lipopolysaccharides/administration & dosage ; Lipopolysaccharides/pharmacology ; Myeloid Differentiation Factor 88/antagonists & inhibitors ; Myeloid Differentiation Factor 88/genetics ; Pyridines/administration & dosage ; Pyridines/pharmacology ; Sesquiterpenes/administration & dosage ; Sesquiterpenes/pharmacology ; Spiro Compounds/administration & dosage ; Spiro Compounds/pharmacology ; Sulfonamides/administration & dosage ; Sulfonamides/pharmacology ; Tissue Culture Techniques ; Toll-Like Receptor 2/agonists ; Toll-Like Receptor 2/antagonists & inhibitors ; Toll-Like Receptor 4/agonists ; Toll-Like Receptor 4/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/genetics
Czasopismo naukowe
Tytuł :
Peptides from Extruded Lupin ( Lupinus albus L.) Regulate Inflammatory Activity via the p38 MAPK Signal Transduction Pathway in RAW 264.7 Cells.
Autorzy :
Gao Y; Institute of Crop Science, Chinese Academy of Agricultural Sciences, No. 80 South Xueyuan Road, Haidian District, Beijing 100081, China.
Zhang X; Institute of Crop Science, Chinese Academy of Agricultural Sciences, No. 80 South Xueyuan Road, Haidian District, Beijing 100081, China.
Ren G; Institute of Crop Science, Chinese Academy of Agricultural Sciences, No. 80 South Xueyuan Road, Haidian District, Beijing 100081, China.
Wu C; College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu Province, China.
Qin P; Institute of Crop Science, Chinese Academy of Agricultural Sciences, No. 80 South Xueyuan Road, Haidian District, Beijing 100081, China.
Yao Y; Institute of Crop Science, Chinese Academy of Agricultural Sciences, No. 80 South Xueyuan Road, Haidian District, Beijing 100081, China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2020 Oct 21; Vol. 68 (42), pp. 11702-11709. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Inflammation/*immunology
Lupinus/*chemistry
Macrophages/*drug effects
Peptides/*pharmacology
p38 Mitogen-Activated Protein Kinases/*immunology
Animals ; Inflammation/genetics ; Macrophages/immunology ; Mice ; Plant Proteins/chemistry ; RAW 264.7 Cells ; Seeds/chemistry ; Tandem Mass Spectrometry ; p38 Mitogen-Activated Protein Kinases/genetics
Czasopismo naukowe
Tytuł :
ROS/p38MAPK-induced lamin B1 accumulation promotes chronic kidney disease-associated vascular smooth muscle cells senescence.
Autorzy :
Wang X; Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Kidney Center of PLA, Xinqiao Hospital, Army Medical University (Third Military Medical University), China; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Xinqiao Street 83, Shapingba District, Chongqing, 400037, China.
Bi X; Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Kidney Center of PLA, Xinqiao Hospital, Army Medical University (Third Military Medical University), China.
Yang K; Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Kidney Center of PLA, Xinqiao Hospital, Army Medical University (Third Military Medical University), China.
Huang Y; Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Kidney Center of PLA, Xinqiao Hospital, Army Medical University (Third Military Medical University), China.
Liu Y; Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Kidney Center of PLA, Xinqiao Hospital, Army Medical University (Third Military Medical University), China.
Zhao J; Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Kidney Center of PLA, Xinqiao Hospital, Army Medical University (Third Military Medical University), China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Oct 15; Vol. 531 (2), pp. 187-194. Date of Electronic Publication: 2020 Aug 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Lamin Type B/*metabolism
Muscle, Smooth, Vascular/*pathology
Myocytes, Smooth Muscle/*pathology
Reactive Oxygen Species/*metabolism
Renal Insufficiency, Chronic/*pathology
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Cell Line ; Cell Nucleus/metabolism ; Humans ; Mice, Inbred C57BL ; Plaque, Atherosclerotic/pathology ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
p38 MAPK Pathway in the Heart: New Insights in Health and Disease.
Autorzy :
Romero-Becerra R; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Santamans AM; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Folgueira C; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Sabio G; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 08; Vol. 21 (19). Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
MAP Kinase Signaling System*/drug effects
Arrhythmias, Cardiac/*metabolism
Cardiomegaly/*metabolism
Heart Failure/*metabolism
Myocardium/*metabolism
Reperfusion Injury/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Regeneration/physiology ; Reperfusion Injury/drug therapy ; Treatment Outcome ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Atorvastatin Reduces Accumulation of Vascular Smooth Muscle Cells to Inhibit Intimal Hyperplasia via p38 MAPK Pathway Inhibition in a Rat Model of Vein Graft.
Autorzy :
Chu T; Department of cardiac Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei - China.
Huang M; Department of cardiac Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei - China.
Zhao Z; Department of cardiac Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei - China.
Ling F; Department of cardiac Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei - China.
Cao J; Department of cardiac Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei - China.
Ge J; Department of cardiac Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei - China.
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Transliterated Title :
Atorvastatina Reduz o Acúmulo de Células Musculares Lisas Vasculares para Inibir a Hiperplasia Intimal pela Inibição de Via p38 MAPK em um Modelo de Enxerto de Veia em Ratos.
Źródło :
Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2020 Oct; Vol. 115 (4), pp. 630-636.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transplants*
p38 Mitogen-Activated Protein Kinases*
Animals ; Atorvastatin/pharmacology ; Atorvastatin/therapeutic use ; Hyperplasia/drug therapy ; Hyperplasia/prevention & control ; Muscle, Smooth, Vascular ; Rats ; Rats, Sprague-Dawley ; Veins
Czasopismo naukowe
Tytuł :
p38 MAPK reins in right ventricular growth.
Autorzy :
Wu T
Chen J
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Oct 01; Vol. 130 (10), pp. 5109-5111.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Heart Ventricles*
p38 Mitogen-Activated Protein Kinases*/genetics
Animals ; Endoribonucleases ; Female ; Heart ; Pregnancy ; Protein-Serine-Threonine Kinases
Czasopismo naukowe
Tytuł :
Mxi-2 Dependent Regulation of p53 in Prostate Cancer.
Autorzy :
KÖditz B; Department of Natural Sciences, University of Applied Sciences Bonn Rhein Sieg, Rheinbach, Germany.; Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Fries JWU; Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
GÖbel H; Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Paffenholz P; Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Richter K; Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Heidenreich A; Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
VON Brandenstein M; Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany .
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Źródło :
Anticancer research [Anticancer Res] 2020 Oct; Vol. 40 (10), pp. 5539-5544.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic/*drug effects
Mitogen-Activated Protein Kinase 14/*genetics
Prostatic Neoplasms/*genetics
Tumor Suppressor Protein p53/*genetics
p38 Mitogen-Activated Protein Kinases/*genetics
Argonaute Proteins/genetics ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Endothelin A Receptor Antagonists/pharmacology ; Endothelin B Receptor Antagonists/pharmacology ; Humans ; Male ; MicroRNAs/genetics ; Prostatic Neoplasms/pathology ; Receptor, Endothelin A/genetics ; Receptor, Endothelin B/genetics ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
NLRC5 negatively regulates inflammatory responses in LPS-induced acute lung injury through NF-κB and p38 MAPK signal pathways.
Autorzy :
Wang Y; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, China; Department of Pharmacology, The Second Hospital of Anhui Medical University, 678 Furong Road, Hefei 230601, Anhui, China.
Huang C; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, China.
Bian E; Department of Pharmacology, The Second Hospital of Anhui Medical University, 678 Furong Road, Hefei 230601, Anhui, China.
Lei T; Department of Pharmacology, The Second Hospital of Anhui Medical University, 678 Furong Road, Hefei 230601, Anhui, China.
Lv X; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, China.
Li J; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Sep 15; Vol. 403, pp. 115150. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute Lung Injury/*chemically induced
Inflammation/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Lipopolysaccharides/*toxicity
NF-kappa B/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Acute Lung Injury/metabolism ; Animals ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/physiology ; Inflammation/genetics ; Intracellular Signaling Peptides and Proteins/genetics ; Mice ; Mice, Inbred C57BL ; NF-kappa B/genetics ; Up-Regulation ; p38 Mitogen-Activated Protein Kinases/genetics
Czasopismo naukowe
Tytuł :
p38 MAPK in Glucose Metabolism of Skeletal Muscle: Beneficial or Harmful?
Autorzy :
Bengal E; Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Haifa 31096, Israel.
Aviram S; Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Haifa 31096, Israel.
Hayek T; Department of Internal Medicine E, Rambam Medical Center, Haifa 31096, Israel.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 04; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Glucose/*metabolism
Muscle, Skeletal/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Biological Transport ; Carbohydrate Metabolism ; Diabetes Mellitus, Type 2/metabolism ; Exercise ; Glucose Intolerance/metabolism ; Humans ; Insulin/metabolism ; Insulin Resistance/physiology ; Obesity/metabolism ; Phosphorylation ; Signal Transduction/physiology ; p38 Mitogen-Activated Protein Kinases/physiology
Czasopismo naukowe
Tytuł :
p38 mitogen-activated protein kinase and pain.
Autorzy :
Mai L; Department of Anesthesiology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.
Zhu X; The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.
Huang F; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.
He H; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.
Fan W; Department of Anesthesiology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 01; Vol. 256, pp. 117885. Date of Electronic Publication: 2020 May 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Pain/*enzymology
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Clinical Trials as Topic ; Enzyme Activation ; Humans ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia.
Autorzy :
Iwamoto M; Department of Pharmacology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan.
Nakamura Y; Department of Pharmacology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan. Electronic address: .
Takemura M; Department of Pharmacology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan.
Hisaoka-Nakashima K; Department of Pharmacology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan.
Morioka N; Department of Pharmacology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan. Electronic address: .
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Źródło :
Journal of pharmacological sciences [J Pharmacol Sci] 2020 Sep; Vol. 144 (1), pp. 23-29. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression/*genetics
Gene Expression Regulation/*genetics
Histone Deacetylase 6/*physiology
MAP Kinase Kinase Kinases/*physiology
MAP Kinase Signaling System/*genetics
MAP Kinase Signaling System/*physiology
Microglia/*metabolism
Neurodegenerative Diseases/*genetics
Receptors, sigma/*genetics
Receptors, sigma/*metabolism
Toll-Like Receptor 4/*physiology
p38 Mitogen-Activated Protein Kinases/*physiology
Animals ; Cells, Cultured ; Down-Regulation/genetics ; MAP Kinase Kinase Kinases/metabolism ; Molecular Targeted Therapy ; Neurodegenerative Diseases/drug therapy ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Receptors, sigma/physiology ; Toll-Like Receptor 4/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe

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