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Tytuł :
Monotypic Plasma Cell Proliferation of Uncertain Clinical Significance Mimicking Interstitial Cystitis: An Early Lesion of MALT Lymphoma?
Autorzy :
Vargas AC; Department of Anatomical Pathology, Douglass Hanly Moir Pathology, Macquarie Park.; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital.; Faculty of Medicine, University of Sydney.
Burchett I; Department of Anatomical Pathology, Douglass Hanly Moir Pathology, Macquarie Park.; School of Medicine, Notre Dame University.; Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW.
Turner J; Department of Anatomical Pathology, Douglass Hanly Moir Pathology, Macquarie Park.; Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW.
Delprado W; Department of Anatomical Pathology, Douglass Hanly Moir Pathology, Macquarie Park.
Brookwell R; Department of Cytogenetics, Sullivan Nicolades Pathology, Brisbane, QLD, Australia.
Chalasani V; Faculty of Medicine, University of Sydney.
Gill AJ; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital.; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonard.; Faculty of Medicine, University of Sydney.
Maclean FM; Department of Anatomical Pathology, Douglass Hanly Moir Pathology, Macquarie Park.; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital.; Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW.
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Źródło :
The American journal of surgical pathology [Am J Surg Pathol] 2021 Jun 01; Vol. 45 (6), pp. 841-853.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation*
Cystitis, Interstitial/*pathology
Lymphoid Tissue/*pathology
Lymphoma, B-Cell, Marginal Zone/*pathology
Plasma Cells/*pathology
Urinary Bladder/*pathology
Urinary Bladder Neoplasms/*pathology
Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biopsy ; Diagnosis, Differential ; Female ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Lymphoid Tissue/chemistry ; Lymphoma, B-Cell, Marginal Zone/chemistry ; Lymphoma, B-Cell, Marginal Zone/genetics ; Male ; Middle Aged ; Plasma Cells/chemistry ; Predictive Value of Tests ; Prospective Studies ; Urinary Bladder/chemistry ; Urinary Bladder Neoplasms/chemistry ; Urinary Bladder Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Nodal EBV-positive polymorphic B cell lymphoproliferative disorder with plasma cell differentiation: clinicopathological analysis of five cases.
Autorzy :
Satou A; Department of Surgical Pathology, Aichi Medical University Hospital, 1-1, Yazakokarimata, Nagakute, 480-1195, Japan. .
Tabata T; Department of Pathology, Okayama University Graduate School of Medicine, Okayama, Japan.
Suzuki Y; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
Sato Y; Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
Tahara I; Department of Pathology, Graduate School of Medicine, University of Yamanashi, Chuo, Japan.
Mochizuki K; Department of Pathology, Graduate School of Medicine, University of Yamanashi, Chuo, Japan.
Oishi N; Department of Pathology, Graduate School of Medicine, University of Yamanashi, Chuo, Japan.
Takahara T; Department of Surgical Pathology, Aichi Medical University Hospital, 1-1, Yazakokarimata, Nagakute, 480-1195, Japan.
Yoshino T; Department of Pathology, Okayama University Graduate School of Medicine, Okayama, Japan.
Tsuzuki T; Department of Surgical Pathology, Aichi Medical University Hospital, 1-1, Yazakokarimata, Nagakute, 480-1195, Japan.
Nakamura S; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 May; Vol. 478 (5), pp. 969-976. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
B-Lymphocytes/*pathology
Epstein-Barr Virus Infections/*pathology
Herpesvirus 4, Human/*pathogenicity
Lymphoma, Large B-Cell, Diffuse/*pathology
Lymphoproliferative Disorders/*pathology
Plasma Cells/*pathology
Aged ; Aged, 80 and over ; Antirheumatic Agents/adverse effects ; B-Lymphocytes/immunology ; B-Lymphocytes/virology ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Diagnosis, Differential ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/virology ; Female ; Genes, Immunoglobulin Heavy Chain ; Genes, T-Cell Receptor gamma ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/immunology ; Host-Pathogen Interactions ; Humans ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/virology ; Lymphoproliferative Disorders/genetics ; Lymphoproliferative Disorders/immunology ; Lymphoproliferative Disorders/virology ; Male ; Methotrexate/adverse effects ; Plasma Cells/immunology ; Plasma Cells/virology ; Predictive Value of Tests ; Risk Factors
Czasopismo naukowe
Tytuł :
The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma.
Autorzy :
Giannakoulas N; Department of Hematology of University Hospital of Larisa, Faculty of Medicine, University of Thessaly, 41110 Larisa, Greece.
Ntanasis-Stathopoulos I; Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Terpos E; Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 24; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Bone Marrow/*pathology
Multiple Myeloma/*pathology
Plasma Cells/*pathology
Tumor Microenvironment/*immunology
Animals ; Bone Marrow/immunology ; Humans ; Multiple Myeloma/immunology ; Plasma Cells/immunology
Czasopismo naukowe
Tytuł :
Rosette-like formation in multiple myeloma.
Autorzy :
Aoki M; Clinical Laboratory, Saitama Medical University International Medical Center, Saitama, 350-1298, Japan.
Takahashi N; Department of Hemato-Oncology, Saitama Medical University International Medical Center, Saitama, 350-1298, Japan.
Taji Y; Clinical Laboratory, Saitama Medical University International Medical Center, Saitama, 350-1298, Japan.
Yasuda M; Department of Pathology, Saitama Medical University International Medical Center, Saitama, 350-1298, Japan.
Asou N; Department of Hemato-Oncology, Saitama Medical University International Medical Center, Saitama, 350-1298, Japan.
Ebihara Y; Department of Laboratory Medicine, Saitama Medical University International Medical Center, Saitama, 350-1298, Japan. .
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Źródło :
Annals of hematology [Ann Hematol] 2021 May; Vol. 100 (5), pp. 1357-1358. Date of Electronic Publication: 2020 May 07.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Bone Marrow Cells/*pathology
Multiple Myeloma/*pathology
Plasma Cells/*pathology
Aged ; B-Lymphocytes/pathology ; Bone Marrow Cells/physiology ; Cell Aggregation ; Erythrocytes/pathology ; Humans ; Male ; Multiple Myeloma/blood ; Plasma Cells/physiology ; Rosette Formation
Raport
Tytuł :
Virus-infected peripheral blood plasmablasts in a patient with severe fever with thrombocytopenia syndrome.
Autorzy :
Takahashi T; Department of Hematology, Yamaguchi Prefectural Grand Medical Center, 10077 Osaki, Hofu, Yamaguchi, 747-8511, Japan. .
Sano K; Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Suzuki T; Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Matsumura T; Department of Hematology, Yamaguchi Prefectural Grand Medical Center, 10077 Osaki, Hofu, Yamaguchi, 747-8511, Japan.
Sakai K; Department of Hematology, Yamaguchi Prefectural Grand Medical Center, 10077 Osaki, Hofu, Yamaguchi, 747-8511, Japan.
Tominaga T; Department of Hematology, Yamaguchi Prefectural Grand Medical Center, 10077 Osaki, Hofu, Yamaguchi, 747-8511, Japan.
Sato Y; Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Katano H; Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Hasegawa H; Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
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Źródło :
International journal of hematology [Int J Hematol] 2021 Mar; Vol. 113 (3), pp. 436-440. Date of Electronic Publication: 2020 Nov 22.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Phlebovirus/*isolation & purification
Plasma Cells/*virology
Precursor Cells, B-Lymphoid/*virology
Severe Fever with Thrombocytopenia Syndrome/*blood
Viremia/*blood
ADP-ribosyl Cyclase 1/analysis ; Aged ; Animals ; Antigens, Viral/analysis ; Bites and Stings/virology ; Cats ; Humans ; Immunophenotyping ; Interferon Regulatory Factors/analysis ; Male ; Membrane Glycoproteins/analysis ; Plasma Cells/chemistry ; Precursor Cells, B-Lymphoid/chemistry ; Severe Fever with Thrombocytopenia Syndrome/virology ; Syndecan-1/analysis ; Tumor Necrosis Factor Receptor Superfamily, Member 7/analysis ; Viremia/virology
Czasopismo naukowe
Tytuł :
Transcriptional heterogeneity of clonal plasma cells and immune evasion in immunoglobulin light chain amyloidosis.
Autorzy :
Wang Y; Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China.
Xu L; Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China.
Liu Y; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital and Institute of Hematology, Beijing, 100044, China.
Hu Y; Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China.
Shi Q; School of Life Sciences, Center for Bioinformatics, Peking University, Beijing, 100871, China.
Jin L; Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China.
Yang L; Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China.
Wang P; Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China.
Zhang K; Translational Stem Cell Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Huang X; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital and Institute of Hematology, Beijing, 100044, China.
Ge Q; Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China. .; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191, China. .; Peking University Health Sciences Center, 38 Xue Yuan Road, Beijing, 100191, China. .
Lu J; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital and Institute of Hematology, Beijing, 100044, China. .; Collaborative Innovation Center of Haematology, Soochow University, Suzhou, Jiangsu, China. .
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Źródło :
International journal of hematology [Int J Hematol] 2021 Feb; Vol. 113 (2), pp. 231-242. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Heterogeneity*
Immune Evasion*
Transcription, Genetic*
Clonal Evolution/*genetics
Immunoglobulin Light-chain Amyloidosis/*etiology
Immunoglobulin Light-chain Amyloidosis/*metabolism
Plasma Cells/*metabolism
Bone Marrow Cells/immunology ; Bone Marrow Cells/metabolism ; Cell Cycle/genetics ; Cells, Cultured ; Computational Biology/methods ; Databases, Genetic ; Disease Susceptibility ; Female ; Gene Expression Profiling ; Humans ; Immunoglobulin Light-chain Amyloidosis/pathology ; Immunoglobulin Light-chain Amyloidosis/therapy ; Male ; Plasma Cells/immunology ; Plasma Cells/pathology
Czasopismo naukowe
Tytuł :
Plasma Cells: From Cytokine Production to Regulation in Experimental Autoimmune Encephalomyelitis.
Autorzy :
Wang AA; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Gommerman JL; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Rojas OL; Department of Immunology, University of Toronto, Toronto, Ontario, Canada. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jan 08; Vol. 433 (1), pp. 166655. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Disease Susceptibility*
Immunomodulation*
Cytokines/*biosynthesis
Plasma Cells/*immunology
Plasma Cells/*metabolism
Animals ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/etiology ; Autoimmune Diseases/metabolism ; Autoimmunity ; Biomarkers ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental ; Humans ; Mice ; Plasma Cells/cytology
Czasopismo naukowe
Tytuł :
CD38 Antibody Daratumumab for the Treatment of Chronic Active Antibody-mediated Kidney Allograft Rejection.
Autorzy :
Doberer K; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Kläger J; Department of Pathology, Medical University of Vienna, Vienna, Austria.
Gualdoni GA; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Mayer KA; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Institute of Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Eskandary F; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Farkash EA; Department of Pathology and Clinical Laboratories, University of Michigan Health System, Ann Arbor, MI.
Agis H; Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Reiter T; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Reindl-Schwaighofer R; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Wahrmann M; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Cohen G; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Haslacher H; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Bond G; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Simonitsch-Klupp I; Department of Pathology, Medical University of Vienna, Vienna, Austria.
Halloran PF; Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada.
Böhmig GA; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
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Źródło :
Transplantation [Transplantation] 2021 Feb 01; Vol. 105 (2), pp. 451-457.
Typ publikacji :
Case Reports
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Graft Rejection/*drug therapy
HLA Antigens/*immunology
Immunosuppressive Agents/*therapeutic use
Isoantibodies/*blood
Kidney Transplantation/*adverse effects
Killer Cells, Natural/*drug effects
Plasma Cells/*drug effects
Chronic Disease ; Graft Rejection/blood ; Graft Rejection/immunology ; Graft Survival/drug effects ; Humans ; Immunity, Cellular/drug effects ; Immunity, Humoral/drug effects ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Male ; Middle Aged ; Plasma Cells/immunology ; Plasma Cells/metabolism ; Treatment Outcome
Raport
Tytuł :
Immunogenetic characterization of clonal plasma cells in systemic light-chain amyloidosis.
Autorzy :
Cuenca I; Hospital 12 de Octubre, Madrid, CNIO, Universidad Complutese, Madrid, Spain.
Alameda D; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain.
Sanchez-Vega B; Hospital 12 de Octubre, Madrid, CNIO, Universidad Complutese, Madrid, Spain.
Gomez-Sanchez D; Clinical and Traslational Lung Cancer Research Unit, i+12 Research Institute and Biomedical Research Networking Center in Oncology (CIBERONC), Madrid, Spain.
Alignani D; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain.
Lasa M; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain.
Onecha E; Hospital 12 de Octubre, Madrid, CNIO, Universidad Complutese, Madrid, Spain.
Lecumberri R; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain.
Prosper F; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain.
Ocio EM; Universidad de Cantabria, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
González ME; Hospital de Cabueñes, Gijon, Spain.
García de Coca A; Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
De La Rubia J; Hospital Doctor Peset, Valencia, Spain.
Gironella M; Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Palomera L; Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain.
Oriol A; Hospital German Trias i Pujol, Badalona, Spain.
Casanova M; Hospital Costa del Sol, Marbella, Spain.
Cabañas V; Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
Taboada F; Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
Pérez-Montaña A; Hospital Son Espases, Palma, Spain.
De Arriba F; Hospital Universitario Morales Meseguer. IMIB-Arrixaca, Murcia, Spain.
Puig N; Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigación del Cancer (IBMCC-USAL, CSIC), Salamanca, Spain.
Carreño-Tarragona G; Hospital 12 de Octubre, Madrid, CNIO, Universidad Complutese, Madrid, Spain.
Barrio S; Hospital 12 de Octubre, Madrid, CNIO, Universidad Complutese, Madrid, Spain.
Enrique de la Puerta J; Hospital de Galdakao, Vizcaya, Spain.
Ramirez-Payer A; Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
Krsnik I; Hospital Puerta de Hierro, Madrid, Spain.
Bargay JJ; Hospital Universitario Son Llàtzer, Palma, Spain.
Lahuerta JJ; Hospital 12 de Octubre, Madrid, CNIO, Universidad Complutese, Madrid, Spain.
Mateos MV; Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigación del Cancer (IBMCC-USAL, CSIC), Salamanca, Spain.
San-Miguel JF; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain.
Paiva B; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain.
Martinez-Lopez J; Hospital 12 de Octubre, Madrid, CNIO, Universidad Complutese, Madrid, Spain. .
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Źródło :
Leukemia [Leukemia] 2021 Jan; Vol. 35 (1), pp. 245-249. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Susceptibility*
Clonal Evolution/*genetics
Clonal Evolution/*immunology
Immunoglobulin Light-chain Amyloidosis/*etiology
Plasma Cells/*immunology
Plasma Cells/*metabolism
Biomarkers ; Disease Management ; Genetic Predisposition to Disease ; Humans ; Immunoglobulin Light-chain Amyloidosis/diagnosis ; Immunoglobulin Light-chain Amyloidosis/metabolism ; Mutation ; Plasma Cells/pathology
Raport
Tytuł :
Systemic Amyloidosis due to Low-Grade Lymphoma.
Autorzy :
Wechalekar AD; National Amyloidosis Centre, University College London (Royal Free Campus), Rowland Hill Street, London NW3 2PF, UK.
Chakraborty R; Multiple Myeloma and Amyloidosis Service, Herbert Irving Pavillion, R 953, 161 Fort Washington Avenue, New York, NY 10032, USA.
Lentzsch S; Multiple Myeloma and Amyloidosis Service, Herbert Irving Pavillion, R 953, 161 Fort Washington Avenue, New York, NY 10032, USA. Electronic address: .
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Źródło :
Hematology/oncology clinics of North America [Hematol Oncol Clin North Am] 2020 Dec; Vol. 34 (6), pp. 1027-1039. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Immunoglobulin Light-chain Amyloidosis*/etiology
Immunoglobulin Light-chain Amyloidosis*/metabolism
Immunoglobulin Light-chain Amyloidosis*/pathology
Plasma Cells*/metabolism
Plasma Cells*/pathology
Waldenstrom Macroglobulinemia*/complications
Waldenstrom Macroglobulinemia*/metabolism
Waldenstrom Macroglobulinemia*/pathology
Immunoglobulin Light Chains/*metabolism
Neoplasm Proteins/*metabolism
Humans ; Immunoglobulin Heavy Chains/metabolism
Czasopismo naukowe
Tytuł :
I-152, a supplier of N-acetyl-cysteine and cysteamine, inhibits immunoglobulin secretion and plasma cell maturation in LP-BM5 murine leukemia retrovirus-infected mice by affecting the unfolded protein response.
Autorzy :
Fraternale A; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy. Electronic address: .
Zara C; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.
Di Mambro T; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.
Manuali E; Laboratory of Histopathology and Clinical Chemistry, Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', 06126 Perugia, Italy.
Genovese DA; Laboratory of Histopathology and Clinical Chemistry, Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', 06126 Perugia, Italy.
Galluzzi L; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.
Diotallevi A; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.
Pompa A; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.
De Marchis F; CNR, Institute of Biosciences and Bioresources (IBBR), 06128 Perugia, Italy.
Ambrogini P; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.
Cesarini E; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.
Luchetti F; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.
Smietana M; Institut des Biomolécules Max Mousseron, Université de Montpellier UMR 5247 CNRS, ENSCM, 34095 Montpellier, France.
Green K; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03766, USA.
Bartoccini F; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.
Magnani M; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.
Crinelli R; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.
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Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2020 Dec 01; Vol. 1866 (12), pp. 165922. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylcysteine/*analogs & derivatives
Antiviral Agents/*pharmacology
Cysteamine/*analogs & derivatives
Immunoglobulins/*metabolism
Plasma Cells/*drug effects
Retroviridae Infections/*drug therapy
Tumor Virus Infections/*drug therapy
Unfolded Protein Response/*drug effects
Acetylcysteine/administration & dosage ; Acetylcysteine/pharmacology ; Animals ; Antiviral Agents/administration & dosage ; Cysteamine/administration & dosage ; Cysteamine/pharmacology ; Disease Models, Animal ; Female ; Immunoglobulins/blood ; Injections, Intraperitoneal ; Leukemia, Experimental/drug therapy ; Leukemia, Experimental/metabolism ; Leukemia, Experimental/virology ; Mice ; Mice, Inbred C57BL ; Plasma Cells/metabolism ; Plasma Cells/virology ; Protein Unfolding/drug effects ; Retroviridae Infections/metabolism ; Retroviridae Infections/virology ; Tumor Virus Infections/metabolism ; Tumor Virus Infections/virology
Czasopismo naukowe
Tytuł :
Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion.
Autorzy :
Rius B; Department of Molecular Medicine.
Mesgarzadeh JS; Department of Molecular Medicine.
Romine IC; Department of Molecular Medicine.
Paxman RJ; Department of Chemistry, and.
Kelly JW; Department of Chemistry, and.; Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA.
Wiseman RL; Department of Molecular Medicine.
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Źródło :
Blood advances [Blood Adv] 2021 Feb 23; Vol. 5 (4), pp. 1037-1049.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Plasma Cells*
Proteostasis*
Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Humans ; Unfolded Protein Response
Czasopismo naukowe
Tytuł :
Multiscale Modeling of Germinal Center Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells Differentiation as Regulated by Antigen Affinity-Based Tfh Cell Help.
Autorzy :
Merino Tejero E; Bioinformatics Laboratory, Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Lashgari D; Bioinformatics Laboratory, Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
García-Valiente R; Bioinformatics Laboratory, Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Gao X; Department of Hematology and Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China.
Crauste F; Université de Paris, CNRS, MAP5 UMR 8145, Paris, France.
Robert PA; Department for Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Meyer-Hermann M; Department for Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.; Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany.
Martínez MR; IBM Research Europe, Zürich, Switzerland.
van Ham SM; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.
Guikema JEJ; Department of Pathology, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam University Medical Centers, Amsterdam, Netherlands.
Hoefsloot H; Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.
van Kampen AHC; Bioinformatics Laboratory, Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.; Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Feb 05; Vol. 11, pp. 620716. Date of Electronic Publication: 2021 Feb 05 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Computer Simulation*
Models, Immunological*
B-Lymphocytes/*immunology
CD40 Antigens/*immunology
Germinal Center/*immunology
Immunologic Memory/*immunology
Lymphopoiesis/*immunology
Plasma Cells/*immunology
T Follicular Helper Cells/*immunology
Asymmetric Cell Division ; B-Lymphocytes/cytology ; Cell Lineage ; Gene Regulatory Networks ; Germinal Center/cytology ; Humans ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/physiology ; Plasma Cells/cytology ; Positive Regulatory Domain I-Binding Factor 1/genetics ; Positive Regulatory Domain I-Binding Factor 1/physiology ; Proto-Oncogene Proteins c-bcl-6/genetics ; Proto-Oncogene Proteins c-bcl-6/physiology ; Signal Transduction ; Time Factors
Czasopismo naukowe
Tytuł :
Cutaneous Involvement in Plasma Cell Myeloma.
Autorzy :
Panse G; Department of Dermatology, Yale School of Medicine, New Haven, CT.; Department of Pathology, Yale School of Medicine, New Haven, CT.
Subtil A; Department of Dermatology, Yale School of Medicine, New Haven, CT.; Department of Pathology, Yale School of Medicine, New Haven, CT.
McNiff JM; Department of Dermatology, Yale School of Medicine, New Haven, CT.; Department of Pathology, Yale School of Medicine, New Haven, CT.
Glusac EJ; Department of Dermatology, Yale School of Medicine, New Haven, CT.; Department of Pathology, Yale School of Medicine, New Haven, CT.
Ko CJ; Department of Dermatology, Yale School of Medicine, New Haven, CT.; Department of Pathology, Yale School of Medicine, New Haven, CT.
Galan A; Department of Dermatology, Yale School of Medicine, New Haven, CT.; Department of Pathology, Yale School of Medicine, New Haven, CT.
Myung P; Department of Dermatology, Yale School of Medicine, New Haven, CT.; Department of Pathology, Yale School of Medicine, New Haven, CT.
Xu ML; Department of Pathology, Yale School of Medicine, New Haven, CT.
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Źródło :
American journal of clinical pathology [Am J Clin Pathol] 2021 Jan 04; Vol. 155 (1), pp. 106-116.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Marrow/*pathology
Multiple Myeloma/*pathology
Plasma Cells/*pathology
Skin/*pathology
Aged ; Aged, 80 and over ; Bone Marrow/metabolism ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Female ; Gene Rearrangement ; Humans ; Immunophenotyping ; Male ; Middle Aged ; Multiple Myeloma/genetics ; Multiple Myeloma/metabolism ; Plasma Cells/metabolism ; Retrospective Studies
Czasopismo naukowe
Tytuł :
B cell analysis in SARS-CoV-2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID-19.
Autorzy :
Wildner NH; Department of Medicine, Section Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ahmadi P; Department of Medicine, Section Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Schulte S; Department of Medicine, Section Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Brauneck F; Department of Medicine, Center for Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Kohsar M; Department of Medicine, Section Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lütgehetmann M; Institute of Medical Microbiology, Virology and Hygiene, Center for Diagnostics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Beisel C; Department of Medicine, Section Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Addo MM; Department of Medicine, Section Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Haag F; Institute of Immunology, Center for Diagnostics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Schulze Zur Wiesch J; Department of Medicine, Section Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Jan; Vol. 109 (1), pp. 77-90. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunologic Memory*
COVID-19/*immunology
Malaria, Falciparum/*immunology
Plasma Cells/*immunology
Plasmodium falciparum/*immunology
SARS-CoV-2/*immunology
Adult ; Aged ; Antigens, CD/immunology ; COVID-19/pathology ; Female ; Humans ; Malaria, Falciparum/pathology ; Male ; Middle Aged ; Plasma Cells/pathology
Czasopismo naukowe
Tytuł :
Cancer immunoediting and immune dysregulation in multiple myeloma.
Autorzy :
Nakamura K; Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia; and.
Smyth MJ; Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia; and.
Martinet L; Cancer Research Center of Toulouse, INSERM UMR 1037, Toulouse, France.
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Źródło :
Blood [Blood] 2020 Dec 10; Vol. 136 (24), pp. 2731-2740.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Immunotherapy*
Multiple Myeloma/*immunology
Multiple Myeloma/*therapy
Plasma Cells/*immunology
Humans ; Multiple Myeloma/pathology ; Plasma Cells/pathology
Czasopismo naukowe
Tytuł :
Vi-Vaccinations Induce Heterogeneous Plasma Cell Responses That Associate With Protection From Typhoid Fever.
Autorzy :
Cross DL; The Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Verheul MK; The Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Leipold MD; The Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford School of Medicine, Stanford, CA, United States.
Obermoser G; The Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford School of Medicine, Stanford, CA, United States.
Jin C; The Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Jones E; The Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Starr JS; The Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Mohorianu I; The Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Blohmke CJ; The Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Maecker HT; The Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford School of Medicine, Stanford, CA, United States.
Napolitani G; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Hill J; The Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Pollard AJ; The Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Dec 03; Vol. 11, pp. 574057. Date of Electronic Publication: 2020 Dec 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Plasma Cells/*immunology
Polysaccharides, Bacterial/*immunology
Salmonella typhi/*immunology
Typhoid Fever/*immunology
Typhoid-Paratyphoid Vaccines/*immunology
ADP-ribosyl Cyclase 1/metabolism ; Adult ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Enzyme-Linked Immunospot Assay ; Flow Cytometry ; Humans ; Immunoglobulin A/metabolism ; Immunologic Memory ; Lymphocyte Activation ; Membrane Glycoproteins/metabolism ; Plasma Cells/metabolism ; T Follicular Helper Cells/immunology ; Tetanus Toxoid/immunology ; Typhoid Fever/prevention & control ; Vaccination ; Vaccines, Conjugate/immunology
Czasopismo naukowe
Tytuł :
The Process of Amyloid Formation due to Monoclonal Immunoglobulins.
Autorzy :
Morgan GJ; Amyloidosis Center and Section of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA. Electronic address: .
Wall JS; Amyloidosis and Cancer Theranostics Program, Preclinical and Diagnostic Molecular Imaging Laboratory, The University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920, USA.
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Źródło :
Hematology/oncology clinics of North America [Hematol Oncol Clin North Am] 2020 Dec; Vol. 34 (6), pp. 1041-1054. Date of Electronic Publication: 2020 Sep 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Amyloid/*metabolism
Antibodies, Monoclonal/*metabolism
Immunoglobulin Light Chains/*metabolism
Immunoglobulin Light-chain Amyloidosis/*metabolism
Plasma Cells/*metabolism
Humans ; Immunoglobulin Light-chain Amyloidosis/pathology ; Plasma Cells/pathology
Czasopismo naukowe

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