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Wyszukujesz frazę ""polyadenylation"" wg kryterium: Temat


Tytuł :
Architectural and functional details of CF IA proteins involved in yeast 3'-end pre-mRNA processing and its significance for eukaryotes: A concise review.
Autorzy :
Kaur M; Department of Biophysics, Panjab University, Chandigarh 160014, India.
Sharma A; Department of Biophysics, Panjab University, Chandigarh 160014, India; University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India.
Singh G; University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India.
Kumar S; Department of Biotechnology, Panjab University, Chandigarh 160014, India; National Centre for Cell Science, NCCS Complex, S. P. Pune University Campus, Ganeshkhind, Pune, Maharashtra 411007, India.
Barnwal RP; Department of Biophysics, Panjab University, Chandigarh 160014, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Dec 15; Vol. 193 (Pt A), pp. 387-400. Date of Electronic Publication: 2021 Oct 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
mRNA Cleavage and Polyadenylation Factors*/chemistry
mRNA Cleavage and Polyadenylation Factors*/physiology
RNA Precursors/*metabolism
Saccharomyces cerevisiae/*metabolism
3' Untranslated Regions ; Humans ; Polyadenylation
Czasopismo naukowe
Tytuł :
A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma .
Autorzy :
Farhat DC; IAB,Team Host-Pathogen Interactions & Immunity to Infection, INSERMU1209, CNRSUMR5309, Grenoble Alpes University, Grenoble, France.
Bowler MW; European Molecular Biology Laboratory, Grenoble, France.
Communie G; Institut Laue-Langevin, Grenoble, France.
Pontier D; Laboratoire Génome et Développement des Plantes (LGDP), UMR5096, Centre National de la Recherche Scientifique (CNRS), Université de Perpignan via Domitia (UPVD), Perpignan, France.
Belmudes L; Univ. Grenoble Alpes, INSERM, CEA, UMR BioSanté U1292, CNRS, CEA, Grenoble, France.
Mas C; Integrated Structural Biology Grenoble (ISBG) CNRS, CEA, Université Grenoble Alpes, EMBL, Grenoble, France.
Corrao C; IAB,Team Host-Pathogen Interactions & Immunity to Infection, INSERMU1209, CNRSUMR5309, Grenoble Alpes University, Grenoble, France.
Couté Y; Univ. Grenoble Alpes, INSERM, CEA, UMR BioSanté U1292, CNRS, CEA, Grenoble, France.
Bougdour A; IAB,Team Host-Pathogen Interactions & Immunity to Infection, INSERMU1209, CNRSUMR5309, Grenoble Alpes University, Grenoble, France.
Lagrange T; Laboratoire Génome et Développement des Plantes (LGDP), UMR5096, Centre National de la Recherche Scientifique (CNRS), Université de Perpignan via Domitia (UPVD), Perpignan, France.
Hakimi MA; IAB,Team Host-Pathogen Interactions & Immunity to Infection, INSERMU1209, CNRSUMR5309, Grenoble Alpes University, Grenoble, France.
Swale C; IAB,Team Host-Pathogen Interactions & Immunity to Infection, INSERMU1209, CNRSUMR5309, Grenoble Alpes University, Grenoble, France.
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Źródło :
ELife [Elife] 2021 Jul 15; Vol. 10. Date of Electronic Publication: 2021 Jul 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Developmental*
Polyadenylation*
Transcriptome*
Membrane Glycoproteins/*metabolism
Nerve Tissue Proteins/*metabolism
Toxoplasma/*metabolism
Arabidopsis/genetics ; Binding Sites ; Cleavage And Polyadenylation Specificity Factor/metabolism ; Gene Expression Regulation ; Humans ; Membrane Glycoproteins/chemistry ; Methyltransferases/metabolism ; Models, Molecular ; Nerve Tissue Proteins/chemistry ; RNA Splicing Factors/chemistry ; RNA, Messenger/metabolism ; Reading ; Sequence Analysis, RNA ; Zinc Fingers
Czasopismo naukowe
Tytuł :
Understanding RNA Binding by the Nonclassical Zinc Finger Protein CPSF30, a Key Factor in Polyadenylation during Pre-mRNA Processing.
Autorzy :
Pritts JD; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201-1180, United States.
Oluyadi AA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201-1180, United States.
Huang W; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201-1180, United States.
Shimberg GD; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201-1180, United States.
Kane MA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201-1180, United States.
Wilks A; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201-1180, United States.
Michel SLJ; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201-1180, United States.
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Źródło :
Biochemistry [Biochemistry] 2021 Mar 16; Vol. 60 (10), pp. 780-790. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Polyadenylation*
Cleavage And Polyadenylation Specificity Factor/*metabolism
Poly U/*metabolism
RNA Precursors/*metabolism
RNA, Messenger/*metabolism
Animals ; Binding Sites ; Cattle ; Cleavage And Polyadenylation Specificity Factor/chemistry ; Cleavage And Polyadenylation Specificity Factor/genetics ; Protein Binding ; RNA Precursors/genetics ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; Zinc Fingers
Czasopismo naukowe
Tytuł :
CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease.
Autorzy :
Picó S; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.
Parras A; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.
Santos-Galindo M; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.
Pose-Utrilla J; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Instituto de Investigaciones Biomédicas 'Alberto Sols,' Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid 28029, Spain.
Castro M; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), Madrid 28049, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid,28029, Spain.
Fraga E; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.
Hernández IH; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Facultad de Ciencias, Departamento de Biología (Unidad Docente Fisiología Animal), Universidad Autónoma de Madrid, Madrid 28049, Spain.
Elorza A; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.
Anta H; Cancer Research Program, Hospital del Mar Medical Research Institute (IMIM), Unidad Asociada I+D+i IMIM-IIBB (CSIC), Barcelona 08003, Spain.; Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology, Barcelona 08028, Spain.
Wang N; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Martí-Sánchez L; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid,28029, Spain.; Department of Clinical Biochemistry, Institut de Recerca Sant Joan de Déu, Barcelona 08950, Spain.
Belloc E; Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology, Barcelona 08028, Spain.
Garcia-Esparcia P; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Institute of Neuropathology, IDIBELL-University Hospital Bellvitge, University of Barcelona, Hospitalet de Llobregat, Barcelona 08908, Spain.
Garrido JJ; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Department of Molecular, Cellular, and Developmental Neurobiology, Instituto Cajal (CSIC), Madrid 28002, Spain.
Ferrer I; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Institute of Neuropathology, IDIBELL-University Hospital Bellvitge, University of Barcelona, Hospitalet de Llobregat, Barcelona 08908, Spain.
Macías-García D; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla 41013, Spain.
Mir P; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla 41013, Spain.
Artuch R; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid,28029, Spain.; Department of Clinical Biochemistry, Institut de Recerca Sant Joan de Déu, Barcelona 08950, Spain.
Pérez B; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), Madrid 28049, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid,28029, Spain.
Hernández F; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.
Navarro P; Cancer Research Program, Hospital del Mar Medical Research Institute (IMIM), Unidad Asociada I+D+i IMIM-IIBB (CSIC), Barcelona 08003, Spain.; Institute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain.
López-Sendón JL; Department of Neurology, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid 28034, Spain.
Iglesias T; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Instituto de Investigaciones Biomédicas 'Alberto Sols,' Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid 28029, Spain.
Yang XW; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Méndez R; Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology, Barcelona 08028, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain.
Lucas JJ; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.
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Źródło :
Science translational medicine [Sci Transl Med] 2021 Sep 29; Vol. 13 (613), pp. eabe7104. Date of Electronic Publication: 2021 Sep 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntington Disease*/genetics
Huntington Disease*/therapy
Polyadenylation*
Transcription Factors/*genetics
mRNA Cleavage and Polyadenylation Factors/*genetics
Humans ; Membrane Transport Proteins ; Transcriptome
Czasopismo naukowe
Tytuł :
Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation.
Autorzy :
Inagaki H; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Hosoda N; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Tsuiji H; Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Hoshino SI; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Nov 20; Vol. 295 (47), pp. 15810-15825. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polyadenylation*
Protein Biosynthesis*
RNA Stability*
Ataxin-2/*metabolism
Cytoplasm/*metabolism
RNA, Messenger/*metabolism
Ataxin-2/genetics ; Cytoplasm/genetics ; HEK293 Cells ; HeLa Cells ; Humans ; Poly(A)-Binding Protein I/genetics ; Poly(A)-Binding Protein I/metabolism ; Polynucleotide Adenylyltransferase/genetics ; Polynucleotide Adenylyltransferase/metabolism ; Protein Binding ; RNA, Messenger/genetics ; mRNA Cleavage and Polyadenylation Factors/genetics ; mRNA Cleavage and Polyadenylation Factors/metabolism
Czasopismo naukowe
Tytuł :
TREND-DB-a transcriptome-wide atlas of the dynamic landscape of alternative polyadenylation.
Autorzy :
Marini F; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, 55131 Mainz, Germany.; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, 55131 Mainz, Germany.
Scherzinger D; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, 55131 Mainz, Germany.
Danckwardt S; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, 55131 Mainz, Germany.; Posttranscriptional Gene Regulation, Cancer Research and Experimental Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany.; Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, 55131 Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Rhine-Main, 55131 Mainz, Germany.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D243-D253.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
3' Untranslated Regions*
Databases, Genetic*
Polyadenylation*
Transcriptome*
Cleavage And Polyadenylation Specificity Factor/*genetics
Cleavage And Polyadenylation Specificity Factor/metabolism ; Gene Expression Regulation ; Humans ; Internet ; Transcription, Genetic ; User-Computer Interface
Czasopismo naukowe
Tytuł :
Comprehensive RNP profiling in cells identifies U1 snRNP complexes with cleavage and polyadenylation factors active in telescripting.
Autorzy :
Cai Z; Department of Biochemistry and Biophysics, School of Medicine, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA, United States.
So BR; Department of Biochemistry and Biophysics, School of Medicine, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA, United States.
Dreyfuss G; Department of Biochemistry and Biophysics, School of Medicine, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA, United States. Electronic address: .
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Źródło :
Methods in enzymology [Methods Enzymol] 2021; Vol. 655, pp. 325-347. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Ribonucleoprotein, U1 Small Nuclear*/genetics
Ribonucleoprotein, U1 Small Nuclear*/metabolism
mRNA Cleavage and Polyadenylation Factors*
Polyadenylation ; Proteomics ; RNA
Czasopismo naukowe
Tytuł :
DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery.
Autorzy :
Inagaki H; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467-8603, Japan.
Hosoda N; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467-8603, Japan.
Hoshino SI; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467-8603, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 14; Vol. 553, pp. 9-16. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polyadenylation*
Ataxin-2/*metabolism
Cytoplasm/*metabolism
DEAD-box RNA Helicases/*metabolism
Polynucleotide Adenylyltransferase/*metabolism
Proto-Oncogene Proteins/*metabolism
mRNA Cleavage and Polyadenylation Factors/*metabolism
Chromatography, Liquid ; HEK293 Cells ; Humans ; Poly A/genetics ; Poly A/metabolism ; Protein Binding ; Protein Interaction Maps ; RNA Stability ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
The microRNA target site landscape is a novel molecular feature associating alternative polyadenylation with immune evasion activity in breast cancer.
Autorzy :
Kim S; Department of Pediatrics, University of Pittsburgh Medical Center and in Division of Pulmonary Medicine, Children's Hospital of Pittsburgh of UPMC.
Bai Y; Department of Human Genetics in the Graduate School of Public Health, University of Pittsburgh.
Fan Z; Department of Computer Science, University of Pittsburgh.
Diergaarde B; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh.
Tseng GC; Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh.
Park HJ; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 May 20; Vol. 22 (3).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
3' Untranslated Regions/*genetics
Breast Neoplasms/*genetics
MicroRNAs/*genetics
Polyadenylation/*genetics
Tumor Escape/*genetics
Algorithms ; Binding Sites/genetics ; Breast Neoplasms/metabolism ; Cell Proliferation/genetics ; Cleavage And Polyadenylation Specificity Factor/genetics ; Cleavage And Polyadenylation Specificity Factor/metabolism ; Gene Expression Regulation, Neoplastic ; HeLa Cells ; Humans ; Models, Genetic ; RNA-Seq/methods ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł :
CPSF30-L: A direct connection between mRNA polyadenylation and m A RNA modification in plants.
Autorzy :
Hunt AG; Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546-0312, USA. Electronic address: .
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Źródło :
Molecular plant [Mol Plant] 2021 May 03; Vol. 14 (5), pp. 711-713. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Arabidopsis/*metabolism
Arabidopsis Proteins/*metabolism
Cleavage And Polyadenylation Specificity Factor/*metabolism
Nitrates/*metabolism
RNA, Messenger/*metabolism
Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Cleavage And Polyadenylation Specificity Factor/genetics ; Polyadenylation/genetics ; Polyadenylation/physiology ; Protein Binding
Czasopismo naukowe
Tytuł :
Dissecting the heterogeneity of the alternative polyadenylation profiles in triple-negative breast cancers.
Autorzy :
Wang L; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Lang GT; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Xue MZ; SARI Center for Stem Cell and Nanomedicine, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, People's Republic of China.
Yang L; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Chen L; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Yao L; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Li XG; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Wang P; Bio-Med Big Data Center, CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, People's Republic of China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, People's Republic of China.
Hu X; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Shao ZM; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, People's Republic of China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, People's Republic of China.
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Źródło :
Theranostics [Theranostics] 2020 Aug 21; Vol. 10 (23), pp. 10531-10547. Date of Electronic Publication: 2020 Aug 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Polyadenylation*
Triple Negative Breast Neoplasms/*genetics
3' Untranslated Regions/genetics ; Apoptosis/genetics ; Breast/pathology ; Carcinogenesis/genetics ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cleavage And Polyadenylation Specificity Factor/metabolism ; Disease-Free Survival ; Female ; Genetic Heterogeneity ; Humans ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Poly(A)-Binding Protein I/metabolism ; Prospective Studies ; RNA-Seq ; Triple Negative Breast Neoplasms/mortality ; Triple Negative Breast Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Shortening of 3' UTRs in most cell types composing tumor tissues implicates alternative polyadenylation in protein metabolism.
Autorzy :
Burri D; Computational and Systems Biology, Biozentrum, University of Basel, Basel, CH-4056, Switzerland SIB Swiss Institute of Bioinformatics, Basel, CH-4056, Switzerland.
Zavolan M; Computational and Systems Biology, Biozentrum, University of Basel, Basel, CH-4056, Switzerland SIB Swiss Institute of Bioinformatics, Basel, CH-4056, Switzerland.
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Źródło :
RNA (New York, N.Y.) [RNA] 2021 Dec; Vol. 27 (12), pp. 1459-1470. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Polyadenylation*
3' Untranslated Regions/*genetics
Adenocarcinoma of Lung/*pathology
Lung Neoplasms/*pathology
RNA, Messenger/*metabolism
Adenocarcinoma of Lung/genetics ; Case-Control Studies ; Humans ; Lung Neoplasms/genetics ; Protein Isoforms ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function.
Autorzy :
Blake D; Immunology Graduate Group and the Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lynch KW; Immunology Graduate Group and the Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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Źródło :
Immunological reviews [Immunol Rev] 2021 Nov; Vol. 304 (1), pp. 30-50. Date of Electronic Publication: 2021 Aug 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Alternative Splicing*/genetics
Polyadenylation*
3' Untranslated Regions ; Apoptosis/genetics ; Humans ; Immunity ; RNA, Messenger
Czasopismo naukowe
Tytuł :
Wilms' tumor 1-associating protein complex regulates alternative splicing and polyadenylation at potential G-quadruplex-forming splice site sequences.
Autorzy :
Horiuchi K; Department of Protein-Protein Interaction Research, Institute for Advanced Medical Sciences, Nippon Medical School, Tokyo, Japan. Electronic address: .
Kawamura T; Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Hamakubo T; Department of Protein-Protein Interaction Research, Institute for Advanced Medical Sciences, Nippon Medical School, Tokyo, Japan. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Nov; Vol. 297 (5), pp. 101248. Date of Electronic Publication: 2021 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
G-Quadruplexes*
Polyadenylation*
Cell Cycle Proteins/*metabolism
Multiprotein Complexes/*metabolism
RNA Splicing Factors/*metabolism
Cell Cycle Proteins/genetics ; CpG Islands ; HEK293 Cells ; Histone Acetyltransferases/biosynthesis ; Histone Acetyltransferases/genetics ; Human Umbilical Vein Endothelial Cells ; Humans ; Multiprotein Complexes/genetics ; RNA Splicing Factors/genetics ; RNA-Seq ; Ubiquitin-Protein Ligases/biosynthesis ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł :
CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression.
Autorzy :
Tan S; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Zhang M; Department of Integrated Traditional Chinese and Western Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.
Shi X; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Ding K; Department of Pathology, School of Basic Medicine, Anhui Medical University, Hefei, 230032, Anhui, China.
Zhao Q; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Guo Q; Department of Pathology, School of Basic Medicine, Anhui Medical University, Hefei, 230032, Anhui, China.
Wang H; Department of Pathology, School of Basic Medicine, Anhui Medical University, Hefei, 230032, Anhui, China.
Wu Z; Department of Pathology, School of Basic Medicine, Anhui Medical University, Hefei, 230032, Anhui, China.
Kang Y; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Zhu T; Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, China. .
Sun J; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China. .
Zhao X; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China. .
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Źródło :
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2021 Mar 01; Vol. 40 (1), pp. 85. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*metabolism
Liver Neoplasms/*metabolism
mRNA Cleavage and Polyadenylation Factors/*metabolism
Animals ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Disease Progression ; Hep G2 Cells ; Heterografts ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Nude ; NAD(P)H Dehydrogenase (Quinone)/genetics ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Polyadenylation ; Survival Analysis ; Up-Regulation ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
Integrator is a genome-wide attenuator of non-productive transcription.
Autorzy :
Lykke-Andersen S; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. Electronic address: .
Žumer K; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Molska EŠ; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Rouvière JO; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Wu G; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Demel C; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Schwalb B; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Schmid M; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Cramer P; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany. Electronic address: .
Jensen TH; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 04; Vol. 81 (3), pp. 514-529.e6. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription Termination, Genetic*
Cleavage And Polyadenylation Specificity Factor/*metabolism
DNA-Binding Proteins/*metabolism
RNA Polymerase II/*metabolism
RNA, Small Nuclear/*biosynthesis
Cleavage And Polyadenylation Specificity Factor/genetics ; DNA-Binding Proteins/genetics ; HeLa Cells ; Humans ; Polyadenylation ; Promoter Regions, Genetic ; RNA Polymerase II/genetics ; RNA, Small Nuclear/genetics
Czasopismo naukowe
Tytuł :
Global 3'-untranslated region landscape mediated by alternative polyadenylation during meiotic maturation of pig oocytes.
Autorzy :
Wu ZW; College of Animal Science, Yangtze University, Jingzhou, China.
Mou Q; College of Animal Science and Technology, Northeast Agricultural University, Harbin, China.
Fang T; College of Animal Science, Yangtze University, Jingzhou, China.
Wang Y; College of Animal Science, Yangtze University, Jingzhou, China.
Liang H; College of Animal Science, Yangtze University, Jingzhou, China.
Wang C; Key Laboratory of Pig Molecular Quantitative Genetics of Anhui Academy of Agricultural Sciences, Anhui Provincial Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei, China.
Du ZQ; College of Animal Science, Yangtze University, Jingzhou, China.
Yang CX; College of Animal Science, Yangtze University, Jingzhou, China.; College of Animal Science and Technology, Northeast Agricultural University, Harbin, China.
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Źródło :
Reproduction in domestic animals = Zuchthygiene [Reprod Domest Anim] 2022 Jan; Vol. 57 (1), pp. 33-44. Date of Electronic Publication: 2021 Oct 21.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Phenomena*
Polyadenylation*
3' Untranslated Regions ; Animals ; Meiosis ; Oocytes/metabolism ; Swine
Czasopismo naukowe
Tytuł :
Genome-Wide Identification of Polyadenylation Dynamics with TED-Seq.
Autorzy :
Kwak Y; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.; Graduate Field of Genetics, Genomics, and Developmental Biology, Cornell University, Ithaca, NY, USA.
Kwak H; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2404, pp. 281-298.
Typ publikacji :
Journal Article
MeSH Terms :
Polyadenylation*
Genome ; Poly A/genetics ; Poly A/metabolism ; RNA Stability ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
aCPSF1 cooperates with terminator U-tract to dictate archaeal transcription termination efficacy.
Autorzy :
Li J; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Yue L; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Li Z; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhang W; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhang B; University of Chinese Academy of Sciences, Beijing, China.; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.
Zhao F; University of Chinese Academy of Sciences, Beijing, China.; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.
Dong X; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
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Źródło :
ELife [Elife] 2021 Dec 29; Vol. 10. Date of Electronic Publication: 2021 Dec 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cleavage And Polyadenylation Specificity Factor*
Terminator Regions, Genetic*
Methanococcus/*genetics
Archaeal Proteins/genetics ; Archaeal Proteins/metabolism ; Transcription Factors/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation.
Autorzy :
Alcott CE; Program in Developmental Biology, Baylor College of Medicine, Houston, United States.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Medical Scientist Training Program, Baylor College of Medicine, Houston, United States.
Yalamanchili HK; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Ji P; Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, United States.
van der Heijden ME; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Department of Neuroscience, Baylor College of Medicine, Houston, United States.
Saltzman A; Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine, Houston, United States.
Elrod N; Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, United States.
Lin A; Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, United States.; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Leng M; Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine, Houston, United States.
Bhatt B; Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine, Houston, United States.
Hao S; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Section of Neurology, Department of Pediatrics, Baylor College of Medicine, Houston, United States.
Wang Q; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Section of Neurology, Department of Pediatrics, Baylor College of Medicine, Houston, United States.
Saliba A; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Tang J; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Section of Neurology, Department of Pediatrics, Baylor College of Medicine, Houston, United States.
Malovannaya A; Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine, Houston, United States.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.; Mass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, United States.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States.
Wagner EJ; Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, United States.
Liu Z; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Section of Neurology, Department of Pediatrics, Baylor College of Medicine, Houston, United States.; Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, United States.
Zoghbi HY; Program in Developmental Biology, Baylor College of Medicine, Houston, United States.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.; Department of Neuroscience, Baylor College of Medicine, Houston, United States.; Department of Pediatrics, Baylor College of Medicine, Houston, United States.; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, United States.
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Źródło :
ELife [Elife] 2020 Apr 22; Vol. 9. Date of Electronic Publication: 2020 Apr 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Polyadenylation*
Cleavage And Polyadenylation Specificity Factor/*physiology
Learning Disabilities/*etiology
Neurons/*metabolism
Animals ; Cells, Cultured ; Cleavage And Polyadenylation Specificity Factor/analysis ; Cleavage And Polyadenylation Specificity Factor/genetics ; DNA Copy Number Variations ; Female ; Gene Expression Regulation ; Hippocampus/metabolism ; Humans ; Male ; Mice, Inbred C57BL
Czasopismo naukowe

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