Temat: "polycyclic compounds" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Autorzy :: Zhou Z; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Li Y; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Ma X; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Cao B; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Peng T; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Sheng Y; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Peng H; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Li R; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Cao Y; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Xi R; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Li F; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Wang M; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Sun H; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Zhang G; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Zhang H; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Hu K; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Xiao W; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Wang F; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; Xiongan Institute of Innovation, Chinese Academy of Sciences, Hebei 071700, China.; Pokaż więcej
Źródło :: Journal of medicinal chemistry [J Med Chem] 2021 Jun 10; Vol. 64 (11), pp. 7404-7421. Date of Electronic Publication: 2021 May 26.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Polycyclic Compounds/*chemistry
RNA-Binding Proteins/*metabolism
Animals ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; DEAD-box RNA Helicases/chemistry ; DEAD-box RNA Helicases/metabolism ; Enoxacin/chemistry ; Enoxacin/metabolism ; Enoxacin/pharmacology ; Enoxacin/therapeutic use ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Mice ; Mice, Nude ; MicroRNAs/metabolism ; Polycyclic Compounds/metabolism ; Polycyclic Compounds/pharmacology ; Polycyclic Compounds/therapeutic use ; Proteome/drug effects ; Proteome/metabolism ; RNA-Binding Proteins/antagonists & inhibitors ; Ribonuclease III/chemistry ; Ribonuclease III/metabolism ; Structure-Activity Relationship ; Transcriptome/drug effects ; Transplantation, Heterologous
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: New approaches to reduce sample processing times for the determination of polycyclic aromatic compounds in environmental samples.
Autorzy :: Xia Z; University of Manitoba, Department of Chemistry, Winnipeg, MB, R3T 2N2, Canada. Electronic address: .
Idowu I; University of Manitoba, Department of Chemistry, Winnipeg, MB, R3T 2N2, Canada.
Kerr E; University of Manitoba, Department of Chemistry, Winnipeg, MB, R3T 2N2, Canada.
Klaassen N; University of Manitoba, Department of Chemistry, Winnipeg, MB, R3T 2N2, Canada.
Assi H; University of Manitoba, Department of Chemistry, Winnipeg, MB, R3T 2N2, Canada.
Bray H; University of Manitoba, Department of Chemistry, Winnipeg, MB, R3T 2N2, Canada.
Marvin C; Water Science and Technology Directorate, Environment and Climate Change Canada, Burlington, ON, L7S 1A1, Canada.
Thomas PJ; Wildlife Landscape Science Directorate, Environment and Climate Change Canada, Ottawa, ON, K1A 0H3, Canada.
Stetefeld J; University of Manitoba, Department of Chemistry, Winnipeg, MB, R3T 2N2, Canada.
Tomy GT; University of Manitoba, Department of Chemistry, Winnipeg, MB, R3T 2N2, Canada. Electronic address: .; Pokaż więcej
Źródło :: Chemosphere [Chemosphere] 2021 Jul; Vol. 274, pp. 129738. Date of Electronic Publication: 2021 Jan 23.
Typ publikacji :: Journal Article
MeSH Terms :: Polycyclic Aromatic Hydrocarbons*/analysis
Polycyclic Compounds*
Gas Chromatography-Mass Spectrometry ; Solid Phase Extraction ; Specimen Handling
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Occurrence of Dechlorane series flame retardants in sediments from the Pearl River Delta, South China.
Autorzy :: Li H; SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou, 510006, China; School of Environment, South China Normal University, Guangzhou, 510006, China. Electronic address: .
Song A; State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Liu H; State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Li Y; Monitoring and Research Center for Eco-Environmental Sciences, Ecology and Environment Administration of Pearl River Valley and South China Sea, Ministry of Ecology and Environment, Guangzhou, 510611, China.
Liu M; State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Sheng G; State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China.
Peng P; State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Ying G; SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou, 510006, China; School of Environment, South China Normal University, Guangzhou, 510006, China.; Pokaż więcej
Źródło :: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2021 Jun 15; Vol. 279, pp. 116902. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :: Journal Article
MeSH Terms :: Flame Retardants*/analysis
Hydrocarbons, Chlorinated*/analysis
Polycyclic Compounds*/analysis
Water Pollutants, Chemical*/analysis
China ; Cities ; Environmental Monitoring ; Geologic Sediments ; Rivers
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: Oral 5-Day Lefamulin for Outpatient Management of Community-Acquired Bacterial Pneumonia: Post-hoc Analysis of the Lefamulin Evaluation Against Pneumonia (LEAP) 2 Trial.
Autorzy :: LoVecchio F; ASU, U of AZ, Creighton, Valleywise Medical Center, University of Arizona, Phoenix, Arizona.
Schranz J; Nabriva Therapeutics US, Inc., King of Prussia, Pennsylvania.
Alexander E; Nabriva Therapeutics US, Inc., King of Prussia, Pennsylvania.
Mariano D; Nabriva Therapeutics US, Inc., King of Prussia, Pennsylvania.
Meads A; Nabriva Therapeutics US, Inc., King of Prussia, Pennsylvania.
Sandrock C; UC Davis School of Medicine, Sacramento, California.
Moran GJ; Olive View-UCLA Medical Center, Los Angeles, California.
Giordano PA; Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida.; Pokaż więcej
Źródło :: The Journal of emergency medicine [J Emerg Med] 2021 Jun; Vol. 60 (6), pp. 781-792. Date of Electronic Publication: 2021 Mar 14.
Typ publikacji :: Journal Article; Randomized Controlled Trial
MeSH Terms :: Community-Acquired Infections*/drug therapy
Pneumonia, Bacterial*/drug therapy
Polycyclic Compounds*
Adult ; Anti-Bacterial Agents/therapeutic use ; Diterpenes ; Fluoroquinolones/pharmacology ; Fluoroquinolones/therapeutic use ; Humans ; Outpatients ; Thioglycolates
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Polycyclic aromatic compounds (PAHs, oxygenated PAHs, nitrated PAHs, and azaarenes) in air from four climate zones of China: Occurrence, gas/particle partitioning, and health risks.
Autorzy :: Wei C; Key Laboratory of Aerosol Chemistry & Physics (KLACP), State Key Laboratory of Loess and Quaternary Geology (SKLLQG), Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 710061, China; Shanghai Carbon Data Research Center (SCDRC), CAS Key Laboratory of Low-Carbon Conversion Science and Engineering, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China. Electronic address: .
Bandowe BAM; Institute of Geography, University of Bern, Hallerstrasse 12, 3012 Bern, Switzerland; Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany. Electronic address: .
Han Y; Key Laboratory of Aerosol Chemistry & Physics (KLACP), State Key Laboratory of Loess and Quaternary Geology (SKLLQG), Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 710061, China; School of Human Settlements and Civil Engineering, Xi'an Jiaotong University, Xi'an 710049, China. Electronic address: .
Cao J; Key Laboratory of Aerosol Chemistry & Physics (KLACP), State Key Laboratory of Loess and Quaternary Geology (SKLLQG), Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 710061, China.
Watson JG; Key Laboratory of Aerosol Chemistry & Physics (KLACP), State Key Laboratory of Loess and Quaternary Geology (SKLLQG), Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 710061, China; Desert Research Institute, 2215 Raggio Parkway, Reno, NV 89512, USA.
Chow JC; Key Laboratory of Aerosol Chemistry & Physics (KLACP), State Key Laboratory of Loess and Quaternary Geology (SKLLQG), Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 710061, China; Desert Research Institute, 2215 Raggio Parkway, Reno, NV 89512, USA.
Wilcke W; Institute of Geography and Geoecology, Karlsruhe Institute of Technology (KIT), Reinhard-Baumeister-Platz 1, 76131 Karlsruhe, Germany.; Pokaż więcej
Źródło :: The Science of the total environment [Sci Total Environ] 2021 Sep 10; Vol. 786, pp. 147234. Date of Electronic Publication: 2021 May 01.
Typ publikacji :: Journal Article
MeSH Terms :: Air Pollutants*/analysis
Polycyclic Aromatic Hydrocarbons*/analysis
Polycyclic Compounds*
China ; Environmental Monitoring ; Nitrates/analysis
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Synthesis and Photobehavior of a NewDehydrobenzoannulene-Based HOF with Fluorine Atoms: From Solution to Single Crystals Observation.
Autorzy :: Gomez E; Physical Chemistry Department, Faculty of Environmental Sciences and Biochemistry, and INAMOL, University of Castilla-La Mancha Departamento de Química Física, Facultad de Ciencias Ambientales y Bioquímica, and INAMOL, Universidad de Castilla-La Mancha, Avenida Carlos III, S.N., 45071 Toledo, Spain.
Hisaki I; Division of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan.
Douhal A; Physical Chemistry Department, Faculty of Environmental Sciences and Biochemistry, and INAMOL, University of Castilla-La Mancha Departamento de Química Física, Facultad de Ciencias Ambientales y Bioquímica, and INAMOL, Universidad de Castilla-La Mancha, Avenida Carlos III, S.N., 45071 Toledo, Spain.; Pokaż więcej
Źródło :: International journal of molecular sciences [Int J Mol Sci] 2021 Apr 30; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :: Journal Article
MeSH Terms :: Alkynes/*chemistry
Fluorine/*chemistry
Polycyclic Compounds/*chemistry
Alkynes/chemical synthesis ; Chemistry Techniques, Synthetic ; Crystallography, X-Ray ; Hydrogen Bonding ; Models, Molecular ; Photochemical Processes ; Polycyclic Compounds/chemical synthesis
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 7 7.

Tytuł :: Alkylated polycyclic aromatic hydrocarbons are the largest contributor to polycyclic aromatic compound concentrations in traditional foods of the Bigstone Cree Nation in Alberta, Canada.
Autorzy :: Golzadeh N; Department of Natural Resource Sciences, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada. Electronic address: .
Barst BD; Water and Environmental Research Center (WERC), University of Alaska Fairbanks, Fairbanks, AK, United States.
Baker JM; Department of Anthropology, Centre for Social Sciences, Athabasca University, Athabasca, Alberta, Canada.
Auger JC; Nukskahtowin and Faculty of Humanities and Social Sciences, Centre for World Indigenous Knowledge and Research, Athabasca University, Athabasca, Alberta, Canada.
McKinney MA; Department of Natural Resource Sciences, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada.; Pokaż więcej
Źródło :: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2021 Apr 15; Vol. 275, pp. 116625. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :: Journal Article
MeSH Terms :: Polycyclic Aromatic Hydrocarbons*/analysis
Polycyclic Compounds*
Alberta ; Animals ; Environmental Monitoring ; Humans ; Oil and Gas Fields
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Fluorescent Molecular Cages with Sucrose and Cyclotriveratrylene Units for the Selective Recognition of Choline and Acetylcholine.
Autorzy :: Szyszka Ł; Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland.
Górecki M; Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland.
Cmoch P; Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland.
Jarosz S; Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland.; Pokaż więcej
Źródło :: The Journal of organic chemistry [J Org Chem] 2021 Apr 02; Vol. 86 (7), pp. 5129-5141. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Choline*
Polycyclic Compounds*
Acetylcholine ; Sucrose
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: Triggering G-Quadruplex Conformation Switching with [7]Helicenes.
Autorzy :: Lousen B; Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100, Copenhagen Ø, Denmark.
Pedersen SK; Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100, Copenhagen Ø, Denmark.
Răsădean DM; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Pantoş GD; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Pittelkow M; Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100, Copenhagen Ø, Denmark.; Pokaż więcej
Źródło :: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Apr 01; Vol. 27 (19), pp. 6064-6069. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :: Journal Article
MeSH Terms :: G-Quadruplexes*
Polycyclic Compounds*
Circular Dichroism ; DNA ; Ligands ; Nucleic Acid Conformation ; Telomere
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: Ultrafast Dynamics and Photoresponse of a Fungi-Derived Pigment Xylindein from Solution to Thin Films.
Autorzy :: Krueger TD; Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, OR, 97331-4003, USA.
Giesbers G; Department of Physics, Oregon State University, 301 Weniger Hall, Corvallis, OR, 97331-6507, USA.
Van Court RC; Department of Wood Science and Engineering, Oregon State University, 119 Richardson Hall, Corvallis, OR, 97331-5704, USA.
Zhu L; Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, OR, 97331-4003, USA.
Kim R; Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, OR, 97331-4003, USA.
Beaudry CM; Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, OR, 97331-4003, USA.
Robinson SC; Department of Wood Science and Engineering, Oregon State University, 119 Richardson Hall, Corvallis, OR, 97331-5704, USA.
Ostroverkhova O; Department of Physics, Oregon State University, 301 Weniger Hall, Corvallis, OR, 97331-6507, USA.
Fang C; Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, OR, 97331-4003, USA.; Pokaż więcej
Źródło :: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Mar 26; Vol. 27 (18), pp. 5627-5631. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :: Journal Article
MeSH Terms :: Polycyclic Compounds*
Protons*
Fungi ; Hydrogen Bonding ; Phenols
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: Dual-Purpose SERS Sensor for Selective Determination of Polycyclic Aromatic Compounds via Electron Donor-Acceptor Traps.
Autorzy :: Eremina OE; Chemistry Department, Lomonosov Moscow State University, 1 Lenin Hills, Moscow 119991, Russia.
Sergeeva EA; Chemistry Department, Lomonosov Moscow State University, 1 Lenin Hills, Moscow 119991, Russia.
Ferree MV; Chemistry Department, Lomonosov Moscow State University, 1 Lenin Hills, Moscow 119991, Russia.
Shekhovtsova TN; Chemistry Department, Lomonosov Moscow State University, 1 Lenin Hills, Moscow 119991, Russia.
Goodilin EA; Chemistry Department, Lomonosov Moscow State University, 1 Lenin Hills, Moscow 119991, Russia.; Faculty of Materials Science, Lomonosov Moscow State University, 1 Lenin Hills, Moscow 119991, Russia.
Veselova IA; Chemistry Department, Lomonosov Moscow State University, 1 Lenin Hills, Moscow 119991, Russia.; Pokaż więcej
Źródło :: ACS sensors [ACS Sens] 2021 Mar 26; Vol. 6 (3), pp. 1057-1066. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Polycyclic Aromatic Hydrocarbons*
Polycyclic Compounds*
Electrons ; Silver ; Spectrum Analysis, Raman
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Mining Natural Products for Macrocycles to Drug Difficult Targets.
Autorzy :: Begnini F; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden.
Poongavanam V; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden.
Over B; Department of Medicinal Chemistry, Research and Early Development, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden.
Castaldo M; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden.
Geschwindner S; Structure, Biophysics & Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden.
Johansson P; Structure, Biophysics & Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden.
Tyagi M; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden.
Tyrchan C; Department of Medicinal Chemistry, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden.
Wissler L; Structure, Biophysics & Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden.
Sjö P; Drugs for Neglected Diseases initiative (DNDi), 15 Chemin Louis Dunant, 1202 Geneva, Switzerland.
Schiesser S; Department of Medicinal Chemistry, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden.
Kihlberg J; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden.; Pokaż więcej
Źródło :: Journal of medicinal chemistry [J Med Chem] 2021 Jan 28; Vol. 64 (2), pp. 1054-1072. Date of Electronic Publication: 2020 Dec 18.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Biological Products/*chemistry
Polycyclic Compounds/*chemical synthesis
Polycyclic Compounds/*pharmacology
Computer Simulation ; Data Mining ; Databases, Factual ; Drug Discovery ; Drug Evaluation, Preclinical ; Humans ; Kelch-Like ECH-Associated Protein 1/antagonists & inhibitors ; Kelch-Like ECH-Associated Protein 1/chemistry ; Microsomes, Liver ; Models, Molecular ; Molecular Docking Simulation ; NF-E2-Related Factor 2 ; Polycyclic Compounds/chemistry ; Solubility ; Structure-Activity Relationship
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: Dechlorane Plus and Related Compounds in Food-A Review.
Autorzy :: Ghelli E; Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, 40064 Bologna, Italy.
Cariou R; LABERCA (Laboratoire d'Etude des Résidus et Contaminants dans les Aliments), Oniris, INRAE (Institut National de Recherche Pour L'agriculture, L'alimentation et L'environnement), F-44307 Nantes, France.
Dervilly G; LABERCA (Laboratoire d'Etude des Résidus et Contaminants dans les Aliments), Oniris, INRAE (Institut National de Recherche Pour L'agriculture, L'alimentation et L'environnement), F-44307 Nantes, France.
Pagliuca G; Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, 40064 Bologna, Italy.; Health Sciences and Technologies-Interdepartmental Center for Industrial Research (CIRI-SDV), University of Bologna, Ozzano dell'Emilia, 40064 Bologna, Italy.
Gazzotti T; Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, 40064 Bologna, Italy.; Health Sciences and Technologies-Interdepartmental Center for Industrial Research (CIRI-SDV), University of Bologna, Ozzano dell'Emilia, 40064 Bologna, Italy.; Pokaż więcej
Źródło :: International journal of environmental research and public health [Int J Environ Res Public Health] 2021 Jan 14; Vol. 18 (2). Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Flame Retardants*/analysis
Hydrocarbons, Chlorinated*/analysis
Polycyclic Compounds*/analysis
Polycyclic Compounds*/toxicity
Environmental Monitoring ; Humans
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 14 14.

Tytuł :: Stepwise frontal analysis coupled with cell membrane chromatography for affinity screening and characterization analysis of bioactive constituent from the mature fruits of schisandra chinensis.
Autorzy :: Wei F; Health Science Center, School of Pharmacy, Xi'an Jiaotong University, 76# Yanta West Road, Xi'an, China.
He X; Health Science Center, School of Pharmacy, Xi'an Jiaotong University, 76# Yanta West Road, Xi'an, China; Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197# Ruijin 2nd Road, Shanghai, China.
Xu K; Jining First People's Hospital, 269# Mencius Avenue, Jining High-tech Zone, Jining, China.
Wang S; Health Science Center, School of Pharmacy, Xi'an Jiaotong University, 76# Yanta West Road, Xi'an, China. Electronic address: .; Pokaż więcej
Źródło :: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2020 Dec 15; Vol. 1161, pp. 122443. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :: Journal Article
MeSH Terms :: Cyclooctanes*/analysis
Cyclooctanes*/chemistry
Cyclooctanes*/pharmacology
Lignans*/analysis
Lignans*/chemistry
Lignans*/pharmacology
Polycyclic Compounds*/analysis
Polycyclic Compounds*/chemistry
Polycyclic Compounds*/pharmacology
Chromatography, Affinity/*methods
Plant Extracts/*chemistry
Schisandra/*chemistry
Adrenergic alpha-1 Receptor Antagonists/metabolism ; Animals ; Cell Membrane/metabolism ; Chromatography, High Pressure Liquid ; Female ; Fruit/chemistry ; Male ; Prostate/drug effects ; Prostatic Hyperplasia ; Rabbits ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 15 15.

Tytuł :: Novel pleuromutilin derivatives with substituted 6-methylpyrimidine: Design, synthesis and antibacterial evaluation.
Autorzy :: Fan Y; Key Laboratory of New Animal Drug Project, Gansu Province, China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs, China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, No. 335, Qilihe District, Lanzhou, 730050, China. Electronic address: .
Liu Y; Key Laboratory of New Animal Drug Project, Gansu Province, China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs, China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, No. 335, Qilihe District, Lanzhou, 730050, China.
Wang H; Key Laboratory of New Animal Drug Project, Gansu Province, China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs, China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, No. 335, Qilihe District, Lanzhou, 730050, China.
Shi T; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.
Cheng F; Key Laboratory of New Animal Drug Project, Gansu Province, China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs, China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, No. 335, Qilihe District, Lanzhou, 730050, China.
Hao B; Key Laboratory of New Animal Drug Project, Gansu Province, China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs, China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, No. 335, Qilihe District, Lanzhou, 730050, China.
Yi Y; Key Laboratory of New Animal Drug Project, Gansu Province, China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs, China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, No. 335, Qilihe District, Lanzhou, 730050, China. Electronic address: .
Shang R; Key Laboratory of New Animal Drug Project, Gansu Province, China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs, China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, No. 335, Qilihe District, Lanzhou, 730050, China. Electronic address: .; Pokaż więcej
Źródło :: European journal of medicinal chemistry [Eur J Med Chem] 2020 Dec 01; Vol. 207, pp. 112735. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :: Journal Article
MeSH Terms :: Drug Design*
Anti-Bacterial Agents/*chemistry
Anti-Bacterial Agents/*pharmacology
Diterpenes/*chemistry
Diterpenes/*pharmacology
Polycyclic Compounds/*chemistry
Polycyclic Compounds/*pharmacology
Staphylococcus/*drug effects
Animals ; Anti-Bacterial Agents/therapeutic use ; Diterpenes/therapeutic use ; Humans ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Mice ; Models, Molecular ; Polycyclic Compounds/therapeutic use ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus/drug effects ; Staphylococcus epidermidis/drug effects ; Streptococcus/drug effects ; Streptococcus agalactiae/drug effects
SCR Organism :: Streptococcus dysgalactiae
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: Design, synthesis and biological evaluation of novel pleuromutilin derivatives containing piperazine and 1,2,3-triazole linker.
Autorzy :: Zhang GY; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Zhang Z; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Li K; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Liu J; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Li B; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Jin Z; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
Liu YH; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
Tang YZ; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China. Electronic address: .; Pokaż więcej
Źródło :: Bioorganic chemistry [Bioorg Chem] 2020 Dec; Vol. 105, pp. 104398. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Drug Design*
Anti-Bacterial Agents/*pharmacology
Cytochrome P-450 Enzyme Inhibitors/*pharmacology
Cytochrome P-450 Enzyme System/*metabolism
Diterpenes/*pharmacology
Methicillin-Resistant Staphylococcus aureus/*drug effects
Polycyclic Compounds/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Cytochrome P-450 Enzyme Inhibitors/chemical synthesis ; Cytochrome P-450 Enzyme Inhibitors/chemistry ; Diterpenes/chemical synthesis ; Diterpenes/chemistry ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Microsomes, Liver/drug effects ; Microsomes, Liver/enzymology ; Molecular Structure ; Piperazine/chemistry ; Piperazine/pharmacology ; Polycyclic Compounds/chemical synthesis ; Polycyclic Compounds/chemistry ; Structure-Activity Relationship ; Triazoles/chemistry ; Triazoles/pharmacology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 17 17.

Tytuł :: Lefamulin: The First Systemic Pleuromutilin Antibiotic.
Autorzy :: Chahine EB; Lloyld L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL, USA.
Sucher AJ; Regis University School of Pharmacy, Denver, CO, USA.; Pokaż więcej
Źródło :: The Annals of pharmacotherapy [Ann Pharmacother] 2020 Dec; Vol. 54 (12), pp. 1203-1214. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Anti-Bacterial Agents/*therapeutic use
Diterpenes/*therapeutic use
Pneumonia, Bacterial/*drug therapy
Polycyclic Compounds/*therapeutic use
Thioglycolates/*therapeutic use
Administration, Intravenous ; Adult ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/pharmacokinetics ; Clinical Trials as Topic ; Community-Acquired Infections ; Diterpenes/adverse effects ; Diterpenes/pharmacokinetics ; Drug Resistance, Bacterial/drug effects ; Humans ; Pneumonia, Bacterial/microbiology ; Polycyclic Compounds/adverse effects ; Polycyclic Compounds/pharmacokinetics ; Thioglycolates/adverse effects ; Thioglycolates/pharmacokinetics ; Treatment Outcome
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Polycyclic aromatic compounds (PACs) in the Canadian environment: Ambient air and deposition.
Autorzy :: Tevlin A; Air Quality Research Division, Environment and Climate Change Canada, 4905 Dufferin Street, Toronto, Ontario, M3H 5T4, Canada.
Galarneau E; Air Quality Research Division, Environment and Climate Change Canada, 4905 Dufferin Street, Toronto, Ontario, M3H 5T4, Canada. Electronic address: .
Zhang T; Air Quality Research Division, Environment and Climate Change Canada, 4905 Dufferin Street, Toronto, Ontario, M3H 5T4, Canada.
Hung H; Air Quality Research Division, Environment and Climate Change Canada, 4905 Dufferin Street, Toronto, Ontario, M3H 5T4, Canada.; Pokaż więcej
Źródło :: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2021 Feb 15; Vol. 271, pp. 116232. Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :: Journal Article
MeSH Terms :: Air Pollutants*/analysis
Polycyclic Aromatic Hydrocarbons*/analysis
Polycyclic Compounds*
Arctic Regions ; Asia ; Canada ; Environmental Monitoring ; Europe ; North America ; Oil and Gas Fields
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: Polycyclic aromatic compounds in particulate matter and indoor dust at preschools in Stockholm, Sweden: Occurrence, sources and genotoxic potential in vitro.
Autorzy :: Lim H; Department of Materials and Environmental Chemistry, Stockholm University, 106 91 Stockholm, Sweden. Electronic address: .
Sadiktsis I; Department of Materials and Environmental Chemistry, Stockholm University, 106 91 Stockholm, Sweden.
de Oliveira Galvão MF; Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden.
Westerholm R; Department of Materials and Environmental Chemistry, Stockholm University, 106 91 Stockholm, Sweden.
Dreij K; Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden. Electronic address: .; Pokaż więcej
Źródło :: The Science of the total environment [Sci Total Environ] 2021 Feb 10; Vol. 755 (Pt 1), pp. 142709. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :: Journal Article
MeSH Terms :: Air Pollutants*/analysis
Air Pollutants*/toxicity
Air Pollution, Indoor*/analysis
Polycyclic Aromatic Hydrocarbons*/analysis
Polycyclic Aromatic Hydrocarbons*/toxicity
Polycyclic Compounds*
Child ; Child, Preschool ; DNA Damage ; Dust/analysis ; Environmental Monitoring ; Humans ; Particulate Matter/analysis ; Particulate Matter/toxicity ; Sweden
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 20 20.

Tytuł :: Co-exposures to trace elements and polycyclic aromatic compounds (PACs) impacts North American river otter (Lontra canadensis) baculum.
Autorzy :: Thomas PJ; Science and Technology Branch, Environment and Climate Change Canada, National Wildlife Research Center, 1125 Colonel By Drive, Raven Road, Ottawa, ON, Canada, K1A 0H3. Electronic address: .
Newell EE; Department of Mechanical Engineering, McMaster University, 1280 Main Street W, Hamilton, ON, Canada, L8S 4L8.
Eccles K; Department of Geography, Geomatics and Environment, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON, Canada, L5L 1C6.
Holloway AC; Department of Obstetrics and Gynecology, McMaster University, 1280 Main Street W, Hamilton, ON, L8S 4L8, Canada.
Idowu I; Centre for Oil and Gas Research and Development, Department of Chemistry, University of Manitoba, 584 Parker Building, Winnipeg, MB, R3T 2N2, Canada.
Xia Z; Centre for Oil and Gas Research and Development, Department of Chemistry, University of Manitoba, 584 Parker Building, Winnipeg, MB, R3T 2N2, Canada.
Hassan E; Department of Mechanical Engineering, McMaster University, 1280 Main Street W, Hamilton, ON, Canada, L8S 4L8.
Tomy G; Centre for Oil and Gas Research and Development, Department of Chemistry, University of Manitoba, 584 Parker Building, Winnipeg, MB, R3T 2N2, Canada.
Quenneville C; Department of Mechanical Engineering, McMaster University, 1280 Main Street W, Hamilton, ON, Canada, L8S 4L8; School of Biomedical Engineering, McMaster University, 1280 Main Street W, Hamilton, ON, Canada, L8S 4L8.; Pokaż więcej
Źródło :: Chemosphere [Chemosphere] 2021 Feb; Vol. 265, pp. 128920. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :: Journal Article
MeSH Terms :: Otters*
Polycyclic Compounds*
Trace Elements*
Alberta ; Animals ; Ecosystem ; Environmental Monitoring ; Male ; Oil and Gas Fields
: Czasopismo naukowe

Szczegóły

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