- Tytuł:
- Identification of Shared Immune Cells and Immune-Related Co-Disease Genes in Chronic Heart Failure and Systemic Lupus Erythematosus Based on Transcriptome Sequencing
- Autorzy:
- Temat:
-
purpose: the purpose was to identify shared immune cells and co-disease genes in chronic heart failure (hf) and systemic lupus erythematosus (sle)
as well as explore thepotential mechanisms of action between hf and sle. methods: a collection of peripheral blood mononuclear cells (pbmcs) from ten patients with hf and sle and ten normal controls (nc) was used for transcriptome sequencing. differentially expressed genes (degs) analysis
enrichment analysis
immune infiltration analysis
weighted gene co-expression network analysis (wgcna)
protein-protein interaction (ppi) analysis
and machine learning were applied for the screening of shared immune cells and co-disease genes in hf and sle. gene expression analysis and correlation analysis were used to explore thepotential mechanisms of co-disease genes and immune cells in hf and sle. results: in this study
it was found that two immune cells
t cells cd4 naïve and monocytes
displayed similar expression patterns in hf and sle at the same time. by taking intersection of the above immune cell-associated genes with the degs common to both hf and sle
four immune-associated co-disease genes
ccr7
rnase2
rnase3 and cxcl10
were finally identified. ccr7
as one of the four key genes
was significantly down-regulated in hf and sle
while the rest three key genes were all significantly up-regulated in both diseases. conclusions: t cells cd4 naïve and monocytes were first revealed as possible shared immune cells of hf and sle
and ccr7
rnase3 and cxcl10 were identified as possible key genes common to hf and sle as well aspotential biomarkers or therapeutic targets for hf and sle.
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950 - Źródło:
- Journal of Inflammation Research, Vol Volume 16, Pp 2689-2705 (2023)
- Opis pliku:
- electronic resource
- Relacje:
- https://www.dovepress.com/identification-of-shared-immune-cells-and-immune-related-co-disease-ge-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031
- Dostęp URL:
- https://doaj.org/article/6d7729571f9b486aa14af26c3ba9568e Link otwiera się w nowym oknie
Czasopismo naukowe