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Tytuł:
Antiviral Activity of Probenecid and Oseltamivir on Influenza Virus Replication.
Autorzy:
Murray J; Department of Infectious Disease, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Martin DE; TrippBio, Inc., Jacksonville, FL 32256, USA.
Sancilio FD; TrippBio, Inc., Jacksonville, FL 32256, USA.
Tripp RA; Department of Infectious Disease, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.; TrippBio, Inc., Jacksonville, FL 32256, USA.
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Źródło:
Viruses [Viruses] 2023 Nov 30; Vol. 15 (12). Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
Influenza, Human*
Influenza Vaccines*/therapeutic use
Humans ; Animals ; Mice ; Oseltamivir/pharmacology ; Oseltamivir/therapeutic use ; Probenecid/pharmacology ; Probenecid/therapeutic use ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Enzyme Inhibitors/pharmacology ; Virus Replication ; Neuraminidase ; Drug Resistance, Viral
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Screening Drugs for Broad-Spectrum, Host-Directed Antiviral Activity: Lessons from the Development of Probenecid for COVID-19.
Autorzy:
Tripp RA; Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
Martin DE; TrippBio, Inc., Jacksonville, FL 32256, USA.
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Źródło:
Viruses [Viruses] 2023 Nov 14; Vol. 15 (11). Date of Electronic Publication: 2023 Nov 14.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*
Humans ; Probenecid/pharmacology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Drug Discovery ; High-Throughput Screening Assays ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Two fabricated carbon paste electrodes for novel potentiometric determination of probenecid in dosage form and human plasma.
Autorzy:
Tantawy MA; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El Aini Street, Cairo, 11562, Egypt. .; Chemistry Department, Faculty of Pharmacy, October 6 University, 6 October City, Giza, Egypt. .
Wahba IA; Pharmaceutical Analytical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science & Technology, 6Th of October City, Giza, Egypt.
Saad SS; Pharmaceutical Analytical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science & Technology, 6Th of October City, Giza, Egypt.
Ramadan NK; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El Aini Street, Cairo, 11562, Egypt.
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Źródło:
Scientific reports [Sci Rep] 2022 Nov 28; Vol. 12 (1), pp. 20418. Date of Electronic Publication: 2022 Nov 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Probenecid*
Carbon*
Humans ; Potentiometry ; Ion-Selective Electrodes ; Poly A
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Probenecid Inhibits Influenza A(H5N1) and A(H7N9) Viruses In Vitro and in Mice.
Autorzy:
Murray J; Animal Health Research Center, Department of Infectious Diseases, College of Veterinary Medicine Athens, University of Georgia, Athens, GA 30605, USA.
Martin DE; TrippBio, Inc., Jacksonville, FL 32256, USA.
Hosking S; Animal Health Research Center, Department of Infectious Diseases, College of Veterinary Medicine Athens, University of Georgia, Athens, GA 30605, USA.
Orr-Burks N; Animal Health Research Center, Department of Infectious Diseases, College of Veterinary Medicine Athens, University of Georgia, Athens, GA 30605, USA.
Hogan RJ; Animal Health Research Center, Department of Infectious Diseases, College of Veterinary Medicine Athens, University of Georgia, Athens, GA 30605, USA.
Tripp RA; Animal Health Research Center, Department of Infectious Diseases, College of Veterinary Medicine Athens, University of Georgia, Athens, GA 30605, USA.; TrippBio, Inc., Jacksonville, FL 32256, USA.
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Źródło:
Viruses [Viruses] 2024 Jan 19; Vol. 16 (1). Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Influenza, Human*
Influenza in Birds*/drug therapy
Influenza in Birds*/prevention & control
Influenza in Birds*/epidemiology
Influenza A Virus, H7N9 Subtype*/genetics
Influenza A Virus, H5N1 Subtype*
Animals ; Humans ; Mice ; Probenecid ; Birds ; Mammals
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Local perfusion of capillaries reveals disrupted beta-amyloid homeostasis at the blood-brain barrier in Tg2576 murine Alzheimer's model.
Autorzy:
Hanafy AS; Department of Neurosurgery, University Hospital Bonn, Bonn, Germany. .; Department of Pharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany. .
Lamprecht A; Department of Pharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany.
Dietrich D; Department of Neurosurgery, University Hospital Bonn, Bonn, Germany.
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Źródło:
Fluids and barriers of the CNS [Fluids Barriers CNS] 2023 Nov 22; Vol. 20 (1), pp. 85. Date of Electronic Publication: 2023 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*/metabolism
Alzheimer Disease*/metabolism
Mice ; Animals ; Amyloid beta-Peptides/metabolism ; Capillaries/metabolism ; Endothelial Cells/metabolism ; Probenecid/metabolism ; Homeostasis ; Perfusion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Oral Probenecid for Nonhospitalized Adults with Symptomatic Mild-to-Moderate COVID-19.
Autorzy:
Martin DE; TrippBio, Inc., Jacksonville, FL 32256, USA.
Pandey N; PCMC's PGI Yashwantrao Chavan Memorial Hospital, Pune 411018, India.
Chavda P; Zenovel Pharma Services LLP, Ahmedabad 380060, India.
Singh G; Clearway Global, Stuart, FL 34997, USA.
Sutariya R; Zenovel Pharma Services LLP, Ahmedabad 380060, India.
Sancilio F; Clearway Global, Stuart, FL 34997, USA.
Tripp RA; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
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Źródło:
Viruses [Viruses] 2023 Jul 06; Vol. 15 (7). Date of Electronic Publication: 2023 Jul 06.
Typ publikacji:
Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*
Humans ; Adult ; SARS-CoV-2 ; Probenecid/adverse effects ; Single-Blind Method ; Antiviral Agents/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Drug repurposing for cardiovascular diseases: New targets and indications for probenecid.
Autorzy:
Onódi Z; Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.; HCEMM-SU Cardiometabolic Immunology Research Group, Semmelweis University, Budapest, Hungary.; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group, Semmelweis University, Budapest, Hungary.
Koch S; Department of Internal Medicine, Division of Cardiovascular Health and Disease, College of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
Rubinstein J; Department of Internal Medicine, Division of Cardiovascular Health and Disease, College of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
Ferdinandy P; Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.; Pharmahungary Group, Szeged, Hungary.
Varga ZV; Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.; HCEMM-SU Cardiometabolic Immunology Research Group, Semmelweis University, Budapest, Hungary.; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group, Semmelweis University, Budapest, Hungary.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2023 Mar; Vol. 180 (6), pp. 685-700. Date of Electronic Publication: 2022 Dec 26.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Cardiovascular Diseases*/drug therapy
Heart Failure*/drug therapy
Myocardial Ischemia*/drug therapy
Coronary Artery Disease*
Humans ; Probenecid/pharmacology ; Probenecid/therapeutic use ; Drug Repositioning
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Stability-Indicating Chromatographic Methods for the Simultaneous Determination of Probenecid and Colchicine in Their Combined Tablet.
Autorzy:
Tantawy MA; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr el Aini Street, 11562, Cairo, Egypt.; Chemistry Department, Faculty of Pharmacy, October 6 University, 6 October City, 12585, Giza, Egypt.
Wahba IA; Pharmaceutical Analytical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science & Technology, 6th of October City, 12568, Giza, Egypt.
Saad SS; Pharmaceutical Analytical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science & Technology, 6th of October City, 12568, Giza, Egypt.
Ramadan NK; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr el Aini Street, 11562, Cairo, Egypt.
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Źródło:
Journal of chromatographic science [J Chromatogr Sci] 2021 Oct 29; Vol. 59 (10), pp. 956-963.
Typ publikacji:
Journal Article
MeSH Terms:
Colchicine*
Probenecid*
Chromatography, High Pressure Liquid ; Chromatography, Thin Layer ; Reproducibility of Results ; Tablets
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Treatment of pseudoxanthoma elasticum with probenecid.
Autorzy:
Osti MH; Department of Dermatology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
Scardamaglia L; Department of Dermatology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.; Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.
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Źródło:
The Australasian journal of dermatology [Australas J Dermatol] 2021 Aug; Vol. 62 (3), pp. 440-441. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji:
Case Reports; Letter
MeSH Terms:
Probenecid/*pharmacology
Pseudoxanthoma Elasticum/*drug therapy
Adult ; Female ; Humans ; Probenecid/therapeutic use ; Pseudoxanthoma Elasticum/diagnosis ; Treatment Outcome ; Uricosuric Agents/pharmacology ; Uricosuric Agents/therapeutic use
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential Action of Connexin Hemichannel and Pannexin Channel Therapeutics for Potential Treatment of Retinal Diseases.
Autorzy:
Mat Nor MN; School of Optometry and Vision Science, University of Auckland, Auckland 1142, New Zealand.; Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu 20400, Malaysia.
Rupenthal ID; Buchanan Ocular Therapeutics Unit, Department of Ophthalmology and New Zealand National Eye Centre, University of Auckland, Auckland 1142, New Zealand.
Green CR; Department of Ophthalmology and New Zealand National Eye Centre, University of Auckland, Auckland 1142, New Zealand.
Acosta ML; School of Optometry and Vision Science, New Zealand National Eye Centre, Centre for Brain Research, Brain Research New Zealand-Rangahau Roro Aotearoa, University of Auckland, Auckland 1142, New Zealand.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 10; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 10.
Typ publikacji:
Journal Article
MeSH Terms:
Benzamides/*therapeutic use
Benzopyrans/*therapeutic use
Connexins/*antagonists & inhibitors
Nerve Tissue Proteins/*antagonists & inhibitors
Probenecid/*therapeutic use
Retina/*drug effects
Retinal Diseases/*drug therapy
Animals ; Benzamides/pharmacology ; Benzopyrans/pharmacology ; Connexin 43/analysis ; Female ; Inflammation/drug therapy ; Inflammation/etiology ; Inflammation/pathology ; Light/adverse effects ; Male ; Probenecid/pharmacology ; Rats ; Rats, Sprague-Dawley ; Retina/pathology ; Retina/radiation effects ; Retinal Diseases/etiology ; Retinal Diseases/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters.
Autorzy:
Ahmad A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, Manchester, UK.
Ogungbenro K; Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, Manchester, UK.
Kunze A; DMPK, Janssen Pharmaceutical Companies, Beerse, Belgium.
Jacobs F; DMPK, Janssen Pharmaceutical Companies, Beerse, Belgium.
Snoeys J; DMPK, Janssen Pharmaceutical Companies, Beerse, Belgium.
Rostami-Hodjegan A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, Manchester, UK.; Simcyp Limited (A Certara Company), Sheffield, UK.
Galetin A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, Manchester, UK.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 May; Vol. 10 (5), pp. 467-477. Date of Electronic Publication: 2021 May 01.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Computer Simulation*
Drug Interactions*
Homovanillic Acid/*pharmacokinetics
Organic Anion Transporters, Sodium-Independent/*metabolism
Probenecid/*pharmacokinetics
Pyridoxic Acid/*pharmacokinetics
Biomarkers/metabolism ; Cross-Over Studies ; Female ; Healthy Volunteers ; Homovanillic Acid/blood ; Humans ; Male ; Organic Anion Transporters, Sodium-Independent/antagonists & inhibitors ; Probenecid/blood ; Pyridoxic Acid/blood
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Probenecid slows disease progression in a murine model of autosomal dominant polycystic kidney disease.
Autorzy:
Arkhipov SN; Division of Hypertension and Vascular Research, Henry Ford Health, Detroit, Michigan, USA.; Department of Physiology, Wayne State University, Detroit, Michigan, USA.
Potter DL; Division of Hypertension and Vascular Research, Henry Ford Health, Detroit, Michigan, USA.
Sultanova RF; Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina, USA.
Ilatovskaya DV; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Harris PC; Department of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Pavlov TS; Division of Hypertension and Vascular Research, Henry Ford Health, Detroit, Michigan, USA.; Department of Physiology, Wayne State University, Detroit, Michigan, USA.
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Źródło:
Physiological reports [Physiol Rep] 2023 Apr; Vol. 11 (7), pp. e15652.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Polycystic Kidney, Autosomal Dominant*/drug therapy
Polycystic Kidney, Autosomal Dominant*/genetics
Polycystic Kidney, Autosomal Dominant*/metabolism
Cysts*/metabolism
Cysts*/pathology
Mice ; Male ; Female ; Humans ; Animals ; Probenecid/pharmacology ; Probenecid/metabolism ; Probenecid/therapeutic use ; Disease Models, Animal ; Kidney/metabolism ; Disease Progression ; Adenosine Triphosphate/metabolism ; TRPP Cation Channels/genetics ; TRPP Cation Channels/metabolism ; TRPP Cation Channels/pharmacology
SCR Disease Name:
Potter Type III Polycystic Kidney Disease
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
OAT3 Participates in Drug-Drug Interaction between Bentysrepinine and Entecavir through Interactions with M8-A Metabolite of Bentysrepinine-In Rats and Humans In Vitro.
Autorzy:
Zhang A; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang 550025, China.; Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, and Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.
Yang F; Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, and Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.
Yuan Y; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Li C; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Huo X; College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Liu J; Heping District Center for Disease Control and Prevention, Tianjin 300070, China.
Zhou S; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Li W; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang N; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liu J; Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, and Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.
Dong S; Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, and Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.
Fan H; Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, and Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.
Peng Y; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zheng J; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang 550025, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 20; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Organic Anion Transporters, Sodium-Independent*/metabolism
Organic Anion Transport Protein 1*/metabolism
Humans ; Rats ; Animals ; Probenecid/metabolism ; Probenecid/pharmacology ; Rats, Wistar ; HEK293 Cells ; Dipeptides/metabolism ; Drug Interactions ; Kidney/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis, X-ray diffraction analysis, quantum chemical studies and α -amylase inhibition of probenecid derived S -alkylphthalimide-oxadiazole-benzenesulfonamide hybrids.
Autorzy:
Khan BA; Department of Chemistry, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.
Hamdani SS; Department of Chemistry, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.; Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.
Ahmed MN; Department of Chemistry, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.
Hameed S; Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.
Ashfaq M; Department of Physics, University of Sargodha, Sargodha, Pakistan.
Shawky AM; Science and Technology Unit (STU), Umm Al-Qura University, Makkah, Saudi Arabia.
Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Sidhom PA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1464-1478.
Typ publikacji:
Journal Article
MeSH Terms:
Oxadiazoles*/pharmacology
alpha-Amylases*
Molecular Docking Simulation ; Molecular Structure ; Probenecid ; Sulfonamides/chemistry ; Sulfonamides/pharmacology ; X-Ray Diffraction ; Benzenesulfonamides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses.
Autorzy:
Wang Q; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Li HY; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Ling ZM; Medical School of Nantong University, Nantong, 226001, Jiangsu, China.; Department of Neurology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China.
Chen G; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China. .; Medical School of Nantong University, Nantong, 226001, Jiangsu, China. .; Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China. .
Wei ZY; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2022 Oct 04; Vol. 19 (1), pp. 244. Date of Electronic Publication: 2022 Oct 04.
Typ publikacji:
Journal Article
MeSH Terms:
Carbenoxolone*/pharmacology
Carbenoxolone*/therapeutic use
Neuralgia*/metabolism
Adenosine Triphosphate/pharmacology ; Animals ; Connexins/genetics ; Connexins/metabolism ; Cytokines/metabolism ; Ethidium/metabolism ; Ethidium/pharmacology ; Ethidium/therapeutic use ; Hyperalgesia/metabolism ; Lipopolysaccharides/pharmacology ; Mice ; Nerve Tissue Proteins/metabolism ; Probenecid/metabolism ; Probenecid/pharmacology ; Probenecid/therapeutic use ; RNA, Small Interfering/metabolism ; Schwann Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Probenecid-Boosted Tenofovir: A Physiologically-Based Pharmacokinetic Model-Informed Strategy for On-Demand HIV Preexposure Prophylaxis.
Autorzy:
Liu SN; Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
Desta Z; Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
Gufford BT; Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2020 Jan; Vol. 9 (1), pp. 40-47. Date of Electronic Publication: 2019 Dec 23.
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Anti-HIV Agents/*pharmacokinetics
Probenecid/*pharmacology
Tenofovir/*pharmacokinetics
Anti-HIV Agents/administration & dosage ; Drug Interactions ; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination/administration & dosage ; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination/pharmacokinetics ; HIV Infections/prevention & control ; Humans ; Organic Anion Transport Protein 1/antagonists & inhibitors ; Organic Anion Transporters, Sodium-Independent/antagonists & inhibitors ; Pre-Exposure Prophylaxis/methods ; Probenecid/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection.
Autorzy:
Rosli S; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia.
Kirby FJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia.
Lawlor KE; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia.
Rainczuk K; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia.
Drummond GR; Department of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, Victoria, Australia.
Mansell A; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia.
Tate MD; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2019 Oct; Vol. 176 (19), pp. 3834-3844. Date of Electronic Publication: 2019 Aug 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Inflammation/*drug therapy
NLR Family, Pyrin Domain-Containing 3 Protein/*antagonists & inhibitors
Orthomyxoviridae Infections/*drug therapy
Probenecid/*pharmacology
Receptors, Purinergic P2X7/*metabolism
Thiazoles/*pharmacology
Animals ; Cells, Cultured ; Drug Repositioning ; Female ; Inflammasomes/drug effects ; Inflammasomes/metabolism ; Inflammation/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Orthomyxoviridae Infections/metabolism ; Probenecid/administration & dosage ; Thiazoles/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
L-Carnitine augments probenecid anti-inflammatory effect in monoiodoacetate-induced knee osteoarthritis in rats: involvement of miRNA-373/P2X7/NLRP3/NF-κB milieu
Autorzy:
Mahfouz, Rawan
H. El-Rewini, SafaaAff1, Aff2
I. Ghoneim, Asser
Sheta, Eman
A. Ali, Mennatallah
Ibrahim, Sherihan Salaheldin AbdelhamidAff1, IDs1078702301376w_cor6
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Źródło:
Inflammopharmacology: Experimental and Therapeutic Studies. 32(1):715-731
Czasopismo naukowe
Szczegóły
Tytuł:
Probenecid Inhibits Respiratory Syncytial Virus (RSV) Replication.
Autorzy:
Murray J; Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
Bergeron HC; Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
Jones LP; Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
Reener ZB; Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
Martin DE; TrippBio, Inc., Jacksonville, FL 32256, USA.
Sancilio FD; Department of Chemistry and Biochemistry, Florida Atlantic University, Jupiter, FL 33431, USA.
Tripp RA; Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.; TrippBio, Inc., Jacksonville, FL 32256, USA.
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Źródło:
Viruses [Viruses] 2022 Apr 27; Vol. 14 (5). Date of Electronic Publication: 2022 Apr 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*
Respiratory Syncytial Virus Infections*/drug therapy
Respiratory Syncytial Virus Infections*/metabolism
Respiratory Syncytial Virus Infections*/prevention & control
Respiratory Syncytial Virus, Human*/genetics
Animals ; Mice ; Probenecid/pharmacology ; Probenecid/therapeutic use ; SARS-CoV-2 ; Virus Replication
Czasopismo naukowe
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