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Tytuł:
Targeting PCSK9 to upregulate MHC-II on the surface of tumor cells in tumor immunotherapy.
Autorzy:
Wang H; Department of Oncology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, No. 321, Zhongshan Road, 210008, Nanjing, China.
Zhang X; Department of Oncology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, No. 321, Zhongshan Road, 210008, Nanjing, China.
Zhang Y; Department of Oncology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, No. 321, Zhongshan Road, 210008, Nanjing, China.
Shi T; Department of Oncology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, No. 321, Zhongshan Road, 210008, Nanjing, China.
Zhang Y; Department of Oncology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, No. 321, Zhongshan Road, 210008, Nanjing, China.
Song X; Department of Oncology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, No. 321, Zhongshan Road, 210008, Nanjing, China.
Liu B; Department of Oncology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, No. 321, Zhongshan Road, 210008, Nanjing, China.
Wang Y; Department of Oncology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, No. 321, Zhongshan Road, 210008, Nanjing, China. .
Wei J; Department of Oncology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, No. 321, Zhongshan Road, 210008, Nanjing, China. .
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Źródło:
BMC cancer [BMC Cancer] 2024 Apr 10; Vol. 24 (1), pp. 445. Date of Electronic Publication: 2024 Apr 10.
Typ publikacji:
Journal Article
MeSH Terms:
Immunotherapy*
Neoplasms*/genetics
Neoplasms*/therapy
Proprotein Convertase 9*/metabolism
Proprotein Convertases*/antagonists & inhibitors
Genes, MHC Class II*
Animals ; Mice ; Histocompatibility Antigens ; Lipoproteins, LDL ; Receptors, LDL/genetics ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Gene Silencing of Angiopoietin-like 3 (ANGPTL3) Induced De Novo Lipogenesis and Lipid Accumulation in Huh7 Cell Line.
Autorzy:
Rossi I; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Marodin G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Lupo MG; Department of Medicine, University of Padova, 35128 Padova, Italy.
Adorni MP; Department of Medicine and Surgery, University of Parma, Via Volturno 39/F, 43125 Parma, Italy.
Papotti B; Department of Food and Drug, University of Parma, Viale delle Scienze 27/A, 43124 Parma, Italy.
Dall'Acqua S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Ferri N; Department of Medicine, University of Padova, 35128 Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Via Orus, 2, 35129 Padova, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 26; Vol. 25 (7). Date of Electronic Publication: 2024 Mar 26.
Typ publikacji:
Journal Article
MeSH Terms:
Lipogenesis*/genetics
Proprotein Convertase 9*
Humans ; Subtilisins ; Gene Silencing ; RNA, Small Interfering/genetics ; Cholesterol ; Angiopoietins/genetics ; Coenzyme A ; Angiopoietin-Like Protein 3
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of a novel LDLR p.Glu179Met variant in Thai families with familial hypercholesterolemia and response to treatment with PCSK9 inhibitor.
Autorzy:
Pussadhamma B; Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Queen Sirikit Heart Center of the Northeast, Khon Kaen University, Khon Kaen, Thailand.
Wongvipaporn C; Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Queen Sirikit Heart Center of the Northeast, Khon Kaen University, Khon Kaen, Thailand.
Wutthimanop A; Department of Internal Medicine, Maharaj Nakhon Si Thammarat Hospital, Nakhon Si Thammarat, Thailand.
Nuinoon M; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand.
Porntadavity S; Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Jeenduang N; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 21; Vol. 14 (1), pp. 6785. Date of Electronic Publication: 2024 Mar 21.
Typ publikacji:
Journal Article
MeSH Terms:
Hyperlipoproteinemia Type II*/drug therapy
Hyperlipoproteinemia Type II*/genetics
Hyperlipoproteinemia Type II*/diagnosis
Proprotein Convertase 9*/genetics
Humans ; Cholesterol, LDL/genetics ; Mutation ; Phenotype ; Receptors, LDL/genetics ; Thailand
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An improved method for estimating low LDL-C based on the enhanced Sampson-NIH equation.
Autorzy:
Coverdell TC; Clinical Center, Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, USA.
Sampson M; Clinical Center, Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, USA.
Zubirán R; Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Wolska A; Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Donato LJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Meeusen JW; Cardiovascular Laboratory Medicine, Mayo Clinic, Rochester, MN, USA.
Jaffe AS; Division of Clinical Core Laboratory Services, Mayo Clinic, Rochester, MN, USA.
Remaley AT; Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. .
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Źródło:
Lipids in health and disease [Lipids Health Dis] 2024 Feb 08; Vol. 23 (1), pp. 43. Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Proprotein Convertase 9*/genetics
Cardiovascular Diseases*/drug therapy
Humans ; Cholesterol, LDL ; Hypolipidemic Agents ; Triglycerides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rewriting DNA in the body lowers cholesterol.
Autorzy:
Kaiser J
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Źródło:
Science (New York, N.Y.) [Science] 2023 Nov 17; Vol. 382 (6672), pp. 751. Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:
Wiadomości
MeSH Terms:
Cholesterol, LDL*/blood
Cholesterol, LDL*/genetics
CRISPR-Cas Systems*
Gene Editing*
Genetic Therapy*/methods
Hyperaldosteronism*/genetics
Hyperaldosteronism*/prevention & control
Proprotein Convertase 9*/blood
Proprotein Convertase 9*/genetics
Humans ; Base Pairing/genetics ; DNA/genetics ; Clinical Trials as Topic
SCR Disease Name:
Familial Hyperaldosteronism
Periodyk
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations.
Autorzy:
Cale JM; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.
Ham KA; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.; Perron Institute for Neurological and Translational Science, Perth, WA, 6009, Australia.
Li D; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.; Perron Institute for Neurological and Translational Science, Perth, WA, 6009, Australia.
McIntosh CS; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.; Perron Institute for Neurological and Translational Science, Perth, WA, 6009, Australia.
Watts GF; School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, 6009, Australia.; Cardiometabolic Clinic, Departments of Cardiology and Internal Medicine, Royal Perth Hospital, Perth, WA, 6000, Australia.
Wilton SD; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.; Perron Institute for Neurological and Translational Science, Perth, WA, 6009, Australia.
Aung-Htut MT; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia. .; Perron Institute for Neurological and Translational Science, Perth, WA, 6009, Australia. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 13; Vol. 13 (1), pp. 19725. Date of Electronic Publication: 2023 Nov 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proprotein Convertase 9*/genetics
Proprotein Convertase 9*/metabolism
Serine Endopeptidases*/metabolism
Alternative Splicing ; Proprotein Convertases/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Association of circulating proprotein convertase subtilisin/kexin type 9 concentration with coagulation abnormalities in patients with primary membranous nephropathy.
Autorzy:
Zhu H; Shandong Provincial Hospital, Shandong University, Jinan, China.
Meng Q; Department of Nephrology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Liu X; Department of Nephrology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Zhai C; Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Sun J; Shandong Provincial Hospital, Shandong University, Jinan, China.; Department of Nephrology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Wang R; Shandong Provincial Hospital, Shandong University, Jinan, China.; Department of Nephrology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Xu L; Department of Nephrology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Yang X; Department of Nephrology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
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Źródło:
Renal failure [Ren Fail] 2023 Dec; Vol. 45 (1), pp. 2212084.
Typ publikacji:
Journal Article
MeSH Terms:
Proprotein Convertase 9*
Glomerulonephritis, Membranous*
Humans ; Factor VIII ; Factor IX ; Thromboplastin ; Subtilisins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Increased serum PCSK9 levels are associated with renal function impairment in patients with type 2 diabetes mellitus.
Autorzy:
Feng Z; Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, P.R. China.; The Critical Kidney Disease Research Center of Central South University, Changsha, P.R. China.
Liao X; Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, P.R. China.; The Critical Kidney Disease Research Center of Central South University, Changsha, P.R. China.
Zhang H; Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, P.R. China.; The Critical Kidney Disease Research Center of Central South University, Changsha, P.R. China.
Peng J; Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, P.R. China.; The Critical Kidney Disease Research Center of Central South University, Changsha, P.R. China.
Huang Z; Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, P.R. China.; The Critical Kidney Disease Research Center of Central South University, Changsha, P.R. China.; Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, P.R. China.
Yi B; Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, P.R. China.; The Critical Kidney Disease Research Center of Central South University, Changsha, P.R. China.
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Źródło:
Renal failure [Ren Fail] 2023 Dec; Vol. 45 (1), pp. 2215880.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/blood
Proprotein Convertase 9*/blood
Diabetic Nephropathies*/blood
Humans ; Animals ; Mice ; Cell Line ; Disease Models, Animal ; Kidney/physiopathology ; Young Adult ; Adult ; Middle Aged ; Aged ; Mice, Inbred C57BL ; Albumins ; Glomerular Filtration Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Elevated circulating PCSK9 level is associated with 28-day mortality in patients with sepsis: a prospective cohort study.
Autorzy:
Shu Y; Evidence-based Medicine and Clinical Center, The First People's Hospital of Huaihua, Huaihua, 418000, P.R. China.
Deng Z; Clinical Pharmacy Department, The First People's Hospital of Huaihua, Huaihua, 418000, P.R. China.
Deng Y; Clinical Pharmacy Department, The First People's Hospital of Huaihua, Huaihua, 418000, P.R. China.
Zhou J; Emergency Department, The First People's Hospital of Huaihua, Huaihua, 418000, P.R. China.
Wang J; Emergency Department, The First People's Hospital of Huaihua, Huaihua, 418000, P.R. China.
Duan Z; Emergency Department, The First People's Hospital of Huaihua, Huaihua, 418000, P.R. China.
Jiang T; Emergency Department, The First People's Hospital of Huaihua, Huaihua, 418000, P.R. China.
Zhao X; Evidence-based Medicine and Clinical Center, The First People's Hospital of Huaihua, Huaihua, 418000, P.R. China.
Shi Z; Clinical Pharmacy Department, The First People's Hospital of Huaihua, Huaihua, 418000, P.R. China.
Qiu C; Evidence-based Medicine and Clinical Center, The First People's Hospital of Huaihua, Huaihua, 418000, P.R. China. .; Clinical Pharmacy Department, The First People's Hospital of Huaihua, Huaihua, 418000, P.R. China. .; School of Basic Medical Sciences, University of South China, Hengyang, 421000, P.R. China. .
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Źródło:
BMC emergency medicine [BMC Emerg Med] 2023 Oct 31; Vol. 23 (1), pp. 127. Date of Electronic Publication: 2023 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proprotein Convertase 9*
Sepsis*
Humans ; Subtilisin ; Prospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Screening and verifying the mutations in the LDLR and APOB genes in a Chinese family with familial hypercholesterolemia.
Autorzy:
Lv X; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China.
Wang C; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China.
Liu L; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China.
Yin G; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China.
Zhang W; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China.
Abdu FA; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China.
Shi T; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China.
Zhang Q; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Tongji Hospital, Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, 1239 Siping Road, Shanghai, 200092, China. .
Che W; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China. .; Department of Cardiology, Shanghai Tenth People's Hospital Chongming Branch, Tongji University School of Medicine, Shanghai, China. .
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Źródło:
Lipids in health and disease [Lipids Health Dis] 2023 Oct 18; Vol. 22 (1), pp. 175. Date of Electronic Publication: 2023 Oct 18.
Typ publikacji:
Journal Article
MeSH Terms:
Apolipoproteins B*/genetics
Hyperlipoproteinemia Type II*/diagnosis
Hyperlipoproteinemia Type II*/drug therapy
Hyperlipoproteinemia Type II*/genetics
Proprotein Convertase 9*/genetics
Receptors, LDL*/genetics
Humans ; Male ; East Asian People/genetics ; Lipids ; Mutation ; Genetic Testing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lp(a) in the Pathogenesis of Aortic Stenosis and Approach to Therapy with Antisense Oligonucleotides or Short Interfering RNA.
Autorzy:
Di Costanzo A; Division of Cardiology, Cardiovascular Research Center, University Magna Graecia Catanzaro, 88100 Catanzaro, Italy.
Indolfi C; Division of Cardiology, Cardiovascular Research Center, University Magna Graecia Catanzaro, 88100 Catanzaro, Italy.
Franzone A; Division of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Esposito G; Division of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Spaccarotella CAM; Division of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 06; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Proprotein Convertase 9*
Aortic Valve Stenosis*/etiology
Aortic Valve Stenosis*/genetics
Aged ; Humans ; Aortic Valve/pathology ; RNA, Small Interfering ; Oligonucleotides, Antisense/therapeutic use ; Artificial Intelligence ; Lipoprotein(a)/genetics ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Exploring PCSK9 Genetic Impact on Lipoprotein(a) via Dual Approaches: Association and Mendelian Randomization.
Autorzy:
Chang YC; Department of Dermatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Tao-Yuan 33305, Taiwan.
Hsu LA; Cardiovascular Division, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Tao-Yuan 33305, Taiwan.
Ko YL; Department of Research, Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 23142, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 28; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
Proprotein Convertase 9*/genetics
Lipoprotein(a)*/genetics
Humans ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PCSK9 promotes T helper 1 and T helper 17 cell differentiation by activating the nuclear factor-κB pathway in ankylosing spondylitis.
Autorzy:
Cai J; Department of Rheumatology and Immunology, Huadong Hospital Affiliated with Fudan University, Shanghai, China.
Jiang Y; Department of Traditional Chinese Medicine and Pharmacy, China Pharmaceutical University, Nanjing, China.
Chen F; Department of Rheumatology and Immunology, Shanghai Qiang-zhi Hospital, Shanghai, China.
Wu S; Department of Rheumatology and Immunology, Shanghai Qiang-zhi Hospital, Shanghai, China.
Ren H; Department of Rheumatology and Immunology, Shanghai Qiang-zhi Hospital, Shanghai, China.
Wang P; Department of Rheumatology and Immunology, Shanghai Qiang-zhi Hospital, Shanghai, China.
Wang J; Department of Rheumatology and Immunology, Shanghai Qiang-zhi Hospital, Shanghai, China.
Liu W; Department of Rheumatology and Immunology, Shanghai Qiang-zhi Hospital, Shanghai, China.
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Źródło:
Immunity, inflammation and disease [Immun Inflamm Dis] 2023 May; Vol. 11 (5), pp. e870.
Typ publikacji:
Journal Article
MeSH Terms:
NF-kappa B*/metabolism
Proprotein Convertase 9*/genetics
Proprotein Convertase 9*/metabolism
Spondylitis, Ankylosing*
Th1 Cells*
Th17 Cells*
Humans ; Cell Differentiation ; Interleukin-17 ; Interleukin-4 ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A new compact adenine base editor generated through deletion of HNH and REC2 domain of SpCas9.
Autorzy:
Qian Y; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, 130062, China.
Wang D; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, 130062, China.
Niu W; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, 130062, China.
Zhao D; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, 130062, China.
Li J; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, 130062, China.
Liu Z; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, 130062, China.
Gao X; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, 130062, China.
Han Y; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, 130062, China. .
Lai L; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, 130062, China. lai_.; CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. lai_.
Li Z; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, 130062, China. lizj_.
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Źródło:
BMC biology [BMC Biol] 2023 Jul 11; Vol. 21 (1), pp. 155. Date of Electronic Publication: 2023 Jul 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proprotein Convertase 9*
RNA, Guide, CRISPR-Cas Systems*
Gene Editing*
Animals ; Humans ; Mice ; Adenine ; HEK293 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clearance and Utilization of Dicarbonyl-Modified LDL in Monkeys and Humans.
Autorzy:
Lankin VZ; Department for Free Radical Biochemistry, E.I. Chazov' National Medical Research Center of Cardiology, Russian Ministry of Health, Moscow 121552, Russia.
Konovalova GG; Department for Free Radical Biochemistry, E.I. Chazov' National Medical Research Center of Cardiology, Russian Ministry of Health, Moscow 121552, Russia.
Domogatsky SP; Department for Free Radical Biochemistry, E.I. Chazov' National Medical Research Center of Cardiology, Russian Ministry of Health, Moscow 121552, Russia.
Tikhaze AK; Department for Free Radical Biochemistry, E.I. Chazov' National Medical Research Center of Cardiology, Russian Ministry of Health, Moscow 121552, Russia.
Klots IN; Research Institute of Medical Primatology, National Research Center 'Kurchatov' Institute', Sochi 354376, Russia.
Ezhov MV; Laboratory of Lipid Disorders, E.I. Chazov' National Medical Research Center of Cardiology, Russian Ministry of Health, Moscow 121552, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 21; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 21.
Typ publikacji:
Journal Article
MeSH Terms:
Proprotein Convertase 9*
Lipoproteins, LDL*
Animals ; Humans ; Haplorhini ; Kinetics ; Fluorescein-5-isothiocyanate ; Glyoxal ; Malondialdehyde
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
LDLR gene's promoter region hypermethylation in patients with familial hypercholesterolemia.
Autorzy:
Zorzo RA; Teaching Institute 'Saúde Com Evidência', Ribeirão Preto, Brazil. .; Ribeirão Preto Medical School, University of São Paulo University, São Paulo, Brazil. .
Suen VMM; Ribeirão Preto Medical School, University of São Paulo University, São Paulo, Brazil.
Santos JE; Ribeirão Preto Medical School, University of São Paulo University, São Paulo, Brazil.
Silva-Jr WA; Ribeirão Preto Medical School, University of São Paulo University, São Paulo, Brazil.
Suazo VK; Pediatrics Department, Pediatric Endocrinology, Ribeirão Preto Medical School, São Paulo University, São Paulo, Brazil.
Honorato ALSC; Ribeirão Preto Medical School, University of São Paulo University, São Paulo, Brazil.
Santos RD; Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil.
Jannes CE; Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil.
Pereira A; Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil.
Krieger JE; Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil.
Liberatore-Jr RDR; Ribeirão Preto Medical School, University of São Paulo University, São Paulo, Brazil.; Pediatrics Department, Pediatric Endocrinology, Ribeirão Preto Medical School, São Paulo University, São Paulo, Brazil.
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 07; Vol. 13 (1), pp. 9241. Date of Electronic Publication: 2023 Jun 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proprotein Convertase 9*/genetics
Hyperlipoproteinemia Type II*/diagnosis
Humans ; Phenotype ; Cholesterol, HDL/genetics ; Apolipoproteins B/genetics ; Promoter Regions, Genetic ; Receptors, LDL/genetics ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evolocumab loaded Bio-Liposomes for efficient atherosclerosis therapy.
Autorzy:
Li Z; Department of Cardiology, The First Hospital of Hunan University of Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Changsha, 410007, China.
Zhu H; Department of Pain, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China.
Liu H; Department of Rehabilitation, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Liu D; Department of Physiology and Pathophysiology, NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China.
Liu J; Department of Cardiology, The First Hospital of Hunan University of Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Changsha, 410007, China.
Jiang J; Department of Cardiology, The First Hospital of Hunan University of Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Changsha, 410007, China.
Zhang Y; Department of Cardiology, The First Hospital of Hunan University of Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Changsha, 410007, China.
Qin Z; Department of Cardiology, The First Hospital of Hunan University of Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Changsha, 410007, China.
Xu Y; Department of Cardiology, The First Hospital of Hunan University of Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Changsha, 410007, China.
Peng Y; Department of Cardiology, The First Hospital of Hunan University of Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Changsha, 410007, China.
Liu B; College of Biology, Hunan University, Changsha, 410082, China. .; Department of Physiology and Pathophysiology, NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China. .
Long Y; Department of Cardiology, The First Hospital of Hunan University of Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Changsha, 410007, China. .
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2023 May 19; Vol. 21 (1), pp. 158. Date of Electronic Publication: 2023 May 19.
Typ publikacji:
Journal Article
MeSH Terms:
Proprotein Convertase 9*/metabolism
Atherosclerosis*/drug therapy
Atherosclerosis*/metabolism
Mice ; Animals ; Liposomes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis.
Autorzy:
Pott J; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. .; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK. .
Kheirkhah A; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.
Gadin JR; Division of Cardiovascular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, Solna, Sweden.
Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany.
Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Kirsten H; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Forer L; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.
Hauck SM; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Burkhardt R; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
März W; Vth Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.; SYNLAB Academy, Synlab Holding Deutschland GmbH, Mannheim and Augsburg, Germany.
Thiery J; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.; Faculty of Medicine, University of Kiel, Kiel, Germany.
Gieger C; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Silveira A; Division of Cardiovascular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, Solna, Sweden.
Hooft FV; Division of Cardiovascular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, Solna, Sweden.
Kronenberg F; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.
Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. .; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. .
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Źródło:
Biology of sex differences [Biol Sex Differ] 2024 Mar 26; Vol. 15 (1), pp. 26. Date of Electronic Publication: 2024 Mar 26.
Typ publikacji:
Meta-Analysis; Journal Article
MeSH Terms:
Hydroxymethylglutaryl-CoA Reductase Inhibitors*
Male ; Humans ; Female ; Proprotein Convertase 9/genetics ; Proprotein Convertase 9/metabolism ; Genome-Wide Association Study ; Cholesterol, LDL/genetics ; Oxidoreductases, N-Demethylating ; Jumonji Domain-Containing Histone Demethylases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Case Series of Genetically Confirmed Index Cases of Familial Hypercholesterolemia in Primary Care.
Autorzy:
Kamal A; Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Kanchau JD; Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Shahuri NS; Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Mohamed-Yassin MS; Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Baharudin N; Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.; Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Abdul Razak S; Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.; Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.; Cardio Vascular and Lungs Research Institute (CaVaLRI), Universiti Teknologi MARA, Bandar Puncak Alam, Selangor, Malaysia.
Badlishah-Sham SF; Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Abdul-Hamid H; Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.; Centre of Academic Primary Care, University of Nottingham, Nottingham, United Kingdom.
Abdul Aziz AF; Department of Family Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.
Al-Khateeb A; Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Chua YA; Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Mohd Kasim NA; Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.; Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Sheikh Abdul Kadir SH; Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Nawawi H; Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Qureshi N; Centre of Academic Primary Care, University of Nottingham, Nottingham, United Kingdom.
Ramli AS; Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.; Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
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Źródło:
The American journal of case reports [Am J Case Rep] 2023 Apr 27; Vol. 24, pp. e939489. Date of Electronic Publication: 2023 Apr 27.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Proprotein Convertase 9*/genetics
Proprotein Convertase 9*/therapeutic use
Hyperlipoproteinemia Type II*/diagnosis
Hyperlipoproteinemia Type II*/genetics
Humans ; Cholesterol, LDL/genetics ; Cholesterol, LDL/therapeutic use ; Phenotype ; Mutation ; Apolipoproteins B/genetics ; Apolipoproteins B/therapeutic use ; Primary Health Care
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
PCSK9, a novel immune and ferroptosis related gene in abdominal aortic aneurysm neck.
Autorzy:
Zhuang J; Department of Vascular Surgery, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China.
Zhu H; Department of Vascular Surgery, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China.; Department of Neurosurgery, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine (Huzhou Central Hospital), NO. 1558 North Sanhuan Road, Huzhou, 313003, Zhejiang, China.; Department of Neurosurgery, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China.
Cheng Z; Department of Neurosurgery, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China.
Hu X; Cancer Center, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China.
Yu X; Department of Vascular Surgery, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China.
Li J; Department of Vascular Surgery, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China.
Liu H; Department of Vascular Surgery, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China.
Tang P; Department of Vascular Surgery, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China.
Zhang Y; Department of Vascular Surgery, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China.
Xiong X; Department of Vascular Surgery, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China. .; Department of Neurosurgery, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine (Huzhou Central Hospital), NO. 1558 North Sanhuan Road, Huzhou, 313003, Zhejiang, China. .; Department of Neurosurgery, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China. .
Deng H; Department of Vascular Surgery, Renmin Hospital of Wuhan University, NO. 99 Zhang Zhidong Road, Wuchang District, Wuhan, 430060, China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Apr 13; Vol. 13 (1), pp. 6054. Date of Electronic Publication: 2023 Apr 13.
Typ publikacji:
Journal Article
MeSH Terms:
Aortic Aneurysm, Abdominal*/genetics
Ferroptosis*/genetics
Proprotein Convertase 9*/genetics
Proprotein Convertase 9*/metabolism
Humans ; Cholesterol ; Cholesterol, LDL ; CTLA-4 Antigen
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 439

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