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Tytuł :
Different Roles of p62 (SQSTM1) Isoforms in Keratin-Related Protein Aggregation.
Autorzy :
Somlapura M; Diagnostic and Research Center for Molecular Biomedicine, Institute of Pathology, Medical University of Graz, 8010 Graz, Austria.
Gottschalk B; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
Lahiri P; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Kufferath I; Diagnostic and Research Center for Molecular Biomedicine, Institute of Pathology, Medical University of Graz, 8010 Graz, Austria.
Pabst D; Diagnostic and Research Center for Molecular Biomedicine, Institute of Pathology, Medical University of Graz, 8010 Graz, Austria.
Rülicke T; Department of Biomedical Sciences, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
Graier WF; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
Denk H; Diagnostic and Research Center for Molecular Biomedicine, Institute of Pathology, Medical University of Graz, 8010 Graz, Austria.
Zatloukal K; Diagnostic and Research Center for Molecular Biomedicine, Institute of Pathology, Medical University of Graz, 8010 Graz, Austria.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 09; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Aggregates*
Keratins/*metabolism
Sequestosome-1 Protein/*metabolism
Animals ; CHO Cells ; Cricetulus ; Humans ; Keratins/genetics ; Mice ; Mice, Knockout ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Sequestosome-1 Protein/genetics
Czasopismo naukowe
Tytuł :
Assessment of protein-protein interfaces in cryo-EM derived assemblies.
Autorzy :
Malhotra S; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, London, UK. .; Scientific Computing Department, Science and Technology Facilities Council, Didcot, UK. .
Joseph AP; Scientific Computing Department, Science and Technology Facilities Council, Didcot, UK.
Thiyagalingam J; Scientific Computing Department, Science and Technology Facilities Council, Didcot, UK.
Topf M; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, London, UK. .; Centre for Structural Systems Biology, Leibniz-Institut für Experimentelle Virologie and Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 07; Vol. 12 (1), pp. 3399. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Interaction Domains and Motifs*
Protein Interaction Maps*
Cryoelectron Microscopy/*methods
Macromolecular Substances/*chemistry
Protein Interaction Mapping/*methods
Proteins/*chemistry
Humans ; Machine Learning ; Macromolecular Substances/metabolism ; Macromolecular Substances/ultrastructure ; Models, Molecular ; Neural Networks, Computer ; Protein Conformation ; Protein Multimerization ; Proteins/metabolism ; Proteins/ultrastructure ; Support Vector Machine ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism ; Viral Nonstructural Proteins/ultrastructure
Czasopismo naukowe
Tytuł :
Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase.
Autorzy :
Kong KE; Institute of Molecular Biology (IMB), Mainz, Germany.
Fischer B; Computational Genome Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Meurer M; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.
Kats I; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.
Li Z; Institute of Molecular Biology (IMB), Mainz, Germany.
Rühle F; Institute of Molecular Biology (IMB), Mainz, Germany.
Barry JD; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Kirrmaier D; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany; Cell Morphogenesis and Signal Transduction, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg, Germany.
Chevyreva V; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.
San Luis BJ; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Costanzo M; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Huber W; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Andrews BJ; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Boone C; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Knop M; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany; Cell Morphogenesis and Signal Transduction, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg, Germany. Electronic address: .
Khmelinskii A; Institute of Molecular Biology (IMB), Mainz, Germany. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Jun 03; Vol. 81 (11), pp. 2460-2476.e11. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
Mitochondrial Proteins/*genetics
Proteasome Endopeptidase Complex/*metabolism
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Ubiquitin-Protein Ligases/*genetics
Gene Expression Profiling ; Gene Expression Regulation, Fungal ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Mitochondrial Proteins/classification ; Mitochondrial Proteins/metabolism ; Protein Transport ; Proteolysis ; Proteomics/methods ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae Proteins/metabolism ; Threonine/metabolism ; Ubiquitin/genetics ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/classification ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
Proteo3Dnet: a web server for the integration of structural information with interactomics data.
Autorzy :
Postic G; Université de Paris, CNRS UMR 8251, INSERM U1133, RPBS, Paris 75205, France.; Institut Français de Bioinformatique (IFB), UMS 3601-CNRS, Université Paris-Saclay, Orsay, France.
Andreani J; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.
Marcoux J; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.
Reys V; Centre de Biochimie Structurale (CBS), CNRS, INSERM, Univ Montpellier, Montpellier, France.
Guerois R; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.
Rey J; Université de Paris, CNRS UMR 8251, INSERM U1133, RPBS, Paris 75205, France.
Mouton-Barbosa E; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.
Vandenbrouck Y; Univ. Grenoble Alpes, INSERM, CEA, UMR BioSanté U1292, CNRS, CEA, FR2048, 38000 Grenoble, France.
Cianferani S; Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, IPHC UMR 7178, 67000 Strasbourg, France.
Burlet-Schiltz O; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.
Labesse G; Centre de Biochimie Structurale (CBS), CNRS, INSERM, Univ Montpellier, Montpellier, France.
Tufféry P; Université de Paris, CNRS UMR 8251, INSERM U1133, RPBS, Paris 75205, France.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 02; Vol. 49 (W1), pp. W567-W572.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Conformation*
Software*
Protein Interaction Mapping/*methods
14-3-3 Proteins/metabolism ; Internet ; Mass Spectrometry ; Protein Interaction Domains and Motifs ; Protein Interaction Maps ; Proteomics ; Ribosome Subunits, Small, Eukaryotic/metabolism
Czasopismo naukowe
Tytuł :
Structural Characterization of Receptor-Receptor Interactions in the Allosteric Modulation of G Protein-Coupled Receptor (GPCR) Dimers.
Autorzy :
Lazim R; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
Suh D; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
Lee JW; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
Vu TNL; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
Yoon S; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
Choi S; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 22; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Models, Molecular*
Protein Conformation*
Protein Multimerization*
Receptors, G-Protein-Coupled/*chemistry
Receptors, G-Protein-Coupled/*metabolism
Allosteric Regulation ; Animals ; Deep Learning ; Humans ; Ligands ; Machine Learning ; Peptides/chemistry ; Peptides/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Rational Engraftment of Quaternary-Interactive Acidic Loops for Anti-HIV-1 Antibody Improvement.
Autorzy :
Liu Q; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA .
Zhang P; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Miao H; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Lin Y; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Kwon YD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Rikhtegaran-Tehrani Z; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
DeVico AL; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Sajadi MM; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Medicine, Baltimore VA Medical Center, Baltimore, Maryland, USA.
Lusso P; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA .
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Źródło :
Journal of virology [J Virol] 2021 May 24; Vol. 95 (12). Date of Electronic Publication: 2021 May 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Binding Sites, Antibody*/immunology
Protein Engineering*
Broadly Neutralizing Antibodies/*immunology
CD4 Antigens/*metabolism
HIV Antibodies/*immunology
HIV Envelope Protein gp120/*chemistry
HIV Envelope Protein gp120/*immunology
HIV-1/*immunology
Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Binding Sites ; Broadly Neutralizing Antibodies/chemistry ; Broadly Neutralizing Antibodies/genetics ; Broadly Neutralizing Antibodies/therapeutic use ; CD4 Antigens/chemistry ; Epitopes/chemistry ; Epitopes/immunology ; HIV Antibodies/chemistry ; HIV Antibodies/genetics ; HIV Antibodies/therapeutic use ; HIV Envelope Protein gp120/metabolism ; HIV Infections/prevention & control ; HIV Infections/therapy ; Humans ; Models, Molecular ; Mutation ; Protein Binding ; Protein Multimerization ; Protein Subunits/chemistry
Czasopismo naukowe
Tytuł :
A Glimpse into the Structural Properties of the Intermediate and Transition State in the Folding of Bromodomain 2 Domain 2 by Φ Value Analysis.
Autorzy :
Novak L; Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza University of Rome, 00185 Rome, Italy.
Petrosino M; Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza University of Rome, 00185 Rome, Italy.
Santorelli D; Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza University of Rome, 00185 Rome, Italy.
Chiaraluce R; Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza University of Rome, 00185 Rome, Italy.
Consalvi V; Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza University of Rome, 00185 Rome, Italy.
Pasquo A; ENEA CR Frascati, Diagnostics and Metrology Laboratory FSN-TECFIS-DIM, 00044 Rome, Italy.
Travaglini-Allocatelli C; Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza University of Rome, 00185 Rome, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 31; Vol. 22 (11). Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Folding*
Protein-Serine-Threonine Kinases/*chemistry
Transcription Factors/*chemistry
Kinetics ; Protein Domains ; Protein Structure, Tertiary
Czasopismo naukowe
Tytuł :
Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function.
Autorzy :
Lin NH; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Yang AW; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Chang CH; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Perng MD; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.; Department of Medical Science, College of Life Sciences, National Tsing Hua University, Hsinchu, Taiwan.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 May; Vol. 35 (5), pp. e21614.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Protein Aggregates*
Alexander Disease/*pathology
Astrocytes/*pathology
Glial Fibrillary Acidic Protein/*chemistry
Glial Fibrillary Acidic Protein/*metabolism
Glutamic Acid/*metabolism
Alexander Disease/metabolism ; Animals ; Astrocytes/metabolism ; Humans ; Mice ; Mice, Transgenic ; Protein Conformation ; Protein Isoforms
Czasopismo naukowe
Tytuł :
Allosteric coupling and biased agonism in G protein-coupled receptors.
Autorzy :
Bock A; Receptor Signaling Lab, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany.
Bermudez M; Institute of Pharmacy, Freie Universität Berlin, Germany.
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Źródło :
The FEBS journal [FEBS J] 2021 Apr; Vol. 288 (8), pp. 2513-2528. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Protein Conformation*
GTP-Binding Proteins/*genetics
Receptors, G-Protein-Coupled/*genetics
beta-Arrestins/*genetics
Allosteric Regulation/genetics ; Binding Sites/genetics ; Humans ; Ligands ; Protein Binding/genetics ; Protein Domains/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes.
Autorzy :
Liu X; Department of Pharmacology, School of Basic Medical Science, Fudan University, Shanghai, China.; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Brain Tumor Center, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America.
Yin L; Department of Pharmacology, School of Basic Medical Science, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Bioactive Small Molecules, Fudan University, Shanghai, China.
Li T; Department of Pharmacology, School of Basic Medical Science, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Bioactive Small Molecules, Fudan University, Shanghai, China.
Lin L; Department of Pharmacology, School of Basic Medical Science, Fudan University, Shanghai, China.
Zhang J; Department of Pharmacology, School of Basic Medical Science, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Bioactive Small Molecules, Fudan University, Shanghai, China.
Li Y; Department of Pharmacology, School of Basic Medical Science, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Bioactive Small Molecules, Fudan University, Shanghai, China.
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Źródło :
PLoS genetics [PLoS Genet] 2021 Mar 17; Vol. 17 (3), pp. e1009415. Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Phenotype*
Protein Aggregates*
Autophagy/*genetics
Nerve Tissue Proteins/*genetics
Nerve Tissue Proteins/*metabolism
Protein Aggregation, Pathological/*genetics
Protein Aggregation, Pathological/*metabolism
Autophagy-Related Protein 12/metabolism ; Autophagy-Related Protein 5/metabolism ; Carrier Proteins ; Cell Survival/genetics ; Disease Susceptibility ; Fluorescent Antibody Technique ; Gene Expression ; Humans ; Models, Biological ; Mutation ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neurons/metabolism ; Protein Binding
Czasopismo naukowe
Tytuł :
Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
Autorzy :
Magnussen HM; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom.
Huang DT; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Mar 05; Vol. 433 (5), pp. 166807. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
Proto-Oncogene Proteins c-mdm2/*chemistry
Tumor Suppressor Protein p53/*chemistry
Ubiquitin/*chemistry
Ubiquitin-Conjugating Enzymes/*chemistry
Amino Acid Sequence ; Animals ; Biocatalysis ; Catalytic Domain ; Conserved Sequence ; Crystallography, X-Ray ; Gene Expression ; Humans ; Mammals ; Models, Molecular ; Protein Aggregates ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Domains ; Protein Interaction Domains and Motifs ; Proto-Oncogene Proteins c-mdm2/genetics ; Proto-Oncogene Proteins c-mdm2/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Ubiquitin/genetics ; Ubiquitin/metabolism ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitin-Conjugating Enzymes/metabolism ; Ubiquitination ; Xenopus ; Zebrafish
Czasopismo naukowe
Tytuł :
DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.
Autorzy :
Popova B; Department of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, University of Goettingen, Göttingen, Germany.
Wang D; Department of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, University of Goettingen, Göttingen, Germany.
Pätz C; Department of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, University of Goettingen, Göttingen, Germany.
Akkermann D; Department of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, University of Goettingen, Göttingen, Germany.
Lázaro DF; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Goettingen, Göttingen, Germany.
Galka D; Department of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, University of Goettingen, Göttingen, Germany.
Kolog Gulko M; Department of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, University of Goettingen, Göttingen, Germany.
Bohnsack MT; Department of Molecular Biology, University Medical Center Goettingen, Göttingen, Germany.
Möbius W; Department of Neurogenetics, Electron Microscopy Core Unit, Max-Planck-Institute of Experimental Medicine, Göttingen, Germany.
Bohnsack KE; Department of Molecular Biology, University Medical Center Goettingen, Göttingen, Germany.
Outeiro TF; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Goettingen, Göttingen, Germany.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Braus GH; Department of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, University of Goettingen, Göttingen, Germany.
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Źródło :
PLoS genetics [PLoS Genet] 2021 Mar 03; Vol. 17 (3), pp. e1009407. Date of Electronic Publication: 2021 Mar 03 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Aggregates*
Protein Multimerization*
DEAD-box RNA Helicases/*metabolism
Protein Aggregation, Pathological/*metabolism
alpha-Synuclein/*metabolism
Amyloid/metabolism ; Amyloid/ultrastructure ; Gene Expression Regulation ; Humans ; Inclusion Bodies/metabolism ; Inclusion Bodies/pathology ; Models, Biological ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Protein Binding ; Protein Transport ; Yeasts/genetics ; Yeasts/metabolism ; alpha-Synuclein/chemistry ; alpha-Synuclein/genetics
Czasopismo naukowe
Tytuł :
Pack a STRIPAK with hubs inside a hub.
Autorzy :
Huang W; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA.
Leonard D; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA.
Taylor DJ; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA. .; Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Mar; Vol. 28 (3), pp. 232-233.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Multimerization*
Multienzyme Complexes/*chemistry
Multienzyme Complexes/*metabolism
Protein Phosphatase 2/*chemistry
Protein Phosphatase 2/*metabolism
Animals ; Calmodulin-Binding Proteins/chemistry ; Calmodulin-Binding Proteins/metabolism ; Calmodulin-Binding Proteins/ultrastructure ; Cryoelectron Microscopy ; Humans ; Membrane Proteins/chemistry ; Membrane Proteins/metabolism ; Membrane Proteins/ultrastructure ; Models, Molecular ; Multienzyme Complexes/ultrastructure ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/metabolism ; Nerve Tissue Proteins/ultrastructure ; Protein Phosphatase 2/ultrastructure ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Protein-Serine-Threonine Kinases/chemistry ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation.
Autorzy :
Ryu HG; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
Jung Y; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
Lee N; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01065, USA.
Seo JY; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
Kim SW; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
Lee KH; Division of Cosmetic Science and Technology, Daegu Haany University, Gyeongsan 38610, Korea.
Kim DY; Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea.
Kim KT; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 23; Vol. 22 (11). Date of Electronic Publication: 2021 May 23.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Biosynthesis*
Heterogeneous Nuclear Ribonucleoprotein A1/*physiology
Intracellular Signaling Peptides and Proteins/*genetics
Lung Neoplasms/*pathology
Neoplasm Proteins/*physiology
Protein-Serine-Threonine Kinases/*genetics
3' Untranslated Regions ; Base Sequence ; CRISPR-Cas Systems ; Cell Cycle ; Cell Line ; Cyclin D1/biosynthesis ; Cyclin D1/genetics ; Eukaryotic Initiation Factor-3/metabolism ; Gene Expression Regulation, Neoplastic ; Genes, Reporter ; Heterogeneous Nuclear Ribonucleoprotein A1/chemistry ; Humans ; Intracellular Signaling Peptides and Proteins/biosynthesis ; Lung Neoplasms/genetics ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Protein Binding ; Protein Domains ; Protein Interaction Mapping ; Protein-Serine-Threonine Kinases/biosynthesis ; RNA Interference ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Recombinant Proteins/metabolism ; Sequence Deletion ; Up-Regulation
Czasopismo naukowe
Tytuł :
Noncanonical interactions of G proteins and β-arrestins: from competitors to companions.
Autorzy :
Smith JS; Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.; Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Dermatology Program, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Pack TF; Sio Gene Therapies, Durham, NC, USA.
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Źródło :
The FEBS journal [FEBS J] 2021 Apr; Vol. 288 (8), pp. 2550-2561. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Protein Conformation*
GTP-Binding Proteins/*genetics
Receptors, G-Protein-Coupled/*genetics
beta-Arrestins/*genetics
HEK293 Cells ; Humans ; Phosphorylation/genetics ; Protein Binding/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Smallest Secondary Nucleation Competent Aβ Aggregates Probed by an ATP-Independent Molecular Chaperone Domain.
Autorzy :
Leppert A; Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 14183 Huddinge, Sweden.
Tiiman A; Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, 17176 Stockholm, Sweden.
Kronqvist N; Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 14183 Huddinge, Sweden.
Landreh M; Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Biomedicum, Solnavägen 9, 17165 Solna, Sweden.
Abelein A; Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 14183 Huddinge, Sweden.
Vukojević V; Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, 17176 Stockholm, Sweden.
Johansson J; Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 14183 Huddinge, Sweden.
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Źródło :
Biochemistry [Biochemistry] 2021 Mar 09; Vol. 60 (9), pp. 678-688. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Chaperones*
Protein Aggregation, Pathological*
Protein Multimerization*
Adenosine Triphosphate/*metabolism
Amyloid beta-Peptides/*chemistry
Amyloid beta-Peptides/*metabolism
Peptide Fragments/*chemistry
Peptide Fragments/*metabolism
Pulmonary Surfactant-Associated Protein C/*metabolism
Humans ; Protein Domains ; Pulmonary Surfactant-Associated Protein C/genetics
Czasopismo naukowe
Tytuł :
Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease.
Autorzy :
Eshraghi M; The Scripps Research Institute, Department of Neuroscience, Jupiter, FL, USA.
Karunadharma PP; The Scripps Research Institute, Genomic Core, Jupiter, FL, USA.
Blin J; Laboratory of Biology and Cellular Modelling at Ecole Normale Supérieure of Lyon, RNA Metabolism in Immunity and Infection Lab, LBMC, Lyon, France.
Shahani N; The Scripps Research Institute, Department of Neuroscience, Jupiter, FL, USA.
Ricci EP; Laboratory of Biology and Cellular Modelling at Ecole Normale Supérieure of Lyon, RNA Metabolism in Immunity and Infection Lab, LBMC, Lyon, France.
Michel A; RiboMaps Ltd, Cork, Ireland.
Urban NT; The Max Planck Neuroscience Institute, Jupiter, FL, USA.
Galli N; The Scripps Research Institute, Department of Neuroscience, Jupiter, FL, USA.
Sharma M; The Scripps Research Institute, Department of Neuroscience, Jupiter, FL, USA.
Ramírez-Jarquín UN; The Scripps Research Institute, Department of Neuroscience, Jupiter, FL, USA.
Florescu K; The Scripps Research Institute, Department of Neuroscience, Jupiter, FL, USA.
Hernandez J; The Scripps Research Institute, Department of Neuroscience, Jupiter, FL, USA.
Subramaniam S; The Scripps Research Institute, Department of Neuroscience, Jupiter, FL, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 05; Vol. 12 (1), pp. 1461. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Huntingtin Protein/*genetics
Huntingtin Protein/*metabolism
Huntington Disease/*genetics
Huntington Disease/*metabolism
Ribosomes/*metabolism
Animals ; Cell Line ; Disease Models, Animal ; Fibroblasts ; Fragile X Mental Retardation Protein/genetics ; Fragile X Mental Retardation Protein/metabolism ; Mice ; Neurons/metabolism ; Ribosomes/genetics ; Transcription Factors/metabolism ; Transcriptome ; Up-Regulation
Czasopismo naukowe
Tytuł :
Structural Dynamic Heterogeneity of Polyubiquitin Subunits Affects Phosphorylation Susceptibility.
Autorzy :
Morimoto D; Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto, 615-8510, Japan.
Walinda E; Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Takashima S; Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto, 615-8510, Japan.
Nishizawa M; Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto, 615-8510, Japan.
Iwai K; Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Shirakawa M; Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto, 615-8510, Japan.
Sugase K; Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto, 615-8510, Japan.
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Źródło :
Biochemistry [Biochemistry] 2021 Mar 02; Vol. 60 (8), pp. 573-583. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
Polyubiquitin/*chemistry
Protein Kinases/*chemistry
Humans ; Models, Molecular ; Phosphorylation ; Polyubiquitin/metabolism ; Protein Binding ; Protein Conformation ; Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Trypanosoma brucei transferrin receptor: Functional replacement of the GPI anchor with a transmembrane domain.
Autorzy :
Kabiri M; Abteilung Parasitologie, Hygiene-Institut der Ruprecht-Karls Universität, Heidelberg, Germany; Sanofi Aventis Deutschland, Translational in Vivo Models, Sanofi Research and Development, Frankfurt, Germany.
Steverding D; Abteilung Parasitologie, Hygiene-Institut der Ruprecht-Karls Universität, Heidelberg, Germany; Bob Champion Research and Education Centre, Norwich Medical School, University of East Anglia, Norwich, United Kingdom. Electronic address: .
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Źródło :
Molecular and biochemical parasitology [Mol Biochem Parasitol] 2021 Mar; Vol. 242, pp. 111361. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
Glycosylphosphatidylinositols/*metabolism
Protein Subunits/*metabolism
Protozoan Proteins/*metabolism
Receptors, Transferrin/*metabolism
Trypanosoma brucei brucei/*metabolism
Base Sequence ; Cell Membrane/chemistry ; Cell Membrane/metabolism ; Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Glycosylation ; Glycosylphosphatidylinositols/chemistry ; Plasmids/chemistry ; Plasmids/metabolism ; Protein Domains ; Protein Engineering ; Protein Multimerization ; Protein Subunits/chemistry ; Protein Subunits/genetics ; Protozoan Proteins/chemistry ; Protozoan Proteins/genetics ; Receptors, Transferrin/chemistry ; Receptors, Transferrin/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Trypanosoma brucei brucei/genetics
Czasopismo naukowe
Tytuł :
Requirement for C-mannosylation to be secreted and activated a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4).
Autorzy :
Miura K; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 223-8522, Japan.
Suzuki T; Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science Wako, 351-0198, Japan.
Sun H; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 223-8522, Japan.
Takada H; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 223-8522, Japan.
Ishizawa Y; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 223-8522, Japan.
Mizuta H; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 223-8522, Japan.
Dohmae N; Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science Wako, 351-0198, Japan.
Simizu S; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 223-8522, Japan. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2021 Mar; Vol. 1865 (3), pp. 129833. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
ADAMTS4 Protein/*metabolism
Aggrecans/*metabolism
Mannose/*metabolism
ADAMTS4 Protein/genetics ; Amino Acid Motifs ; Amino Acid Substitution ; Binding Sites ; Cell Line, Tumor ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Kinetics ; Mutation ; Protein Binding ; Protein Interaction Domains and Motifs ; Proteolysis ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Substrate Specificity ; Thermodynamics
Czasopismo naukowe

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