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Tytuł:
AR antagonists develop drug resistance through TOMM20 autophagic degradation-promoted transformation to neuroendocrine prostate cancer.
Autorzy:
Yin L; Key Laboratory of Clinical Precision Pharmacy of Guangdong Higher Education Institutes, The First Affiliated Hospital, Guangdong Pharmaceutical University, 19 Nonglinxia Road, Yuexiu District, Guangzhou, Guangdong, China.; Clinical Pharmacy, The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangdong, China.; School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangdong, China.
Ye Y; School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangdong, China.
Zou L; School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangdong, China.
Lin J; School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangdong, China.
Dai Y; School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangdong, China.
Fu Y; Key Laboratory of Clinical Precision Pharmacy of Guangdong Higher Education Institutes, The First Affiliated Hospital, Guangdong Pharmaceutical University, 19 Nonglinxia Road, Yuexiu District, Guangzhou, Guangdong, China.; Clinical Pharmacy, The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangdong, China.
Liu Y; Department of Oncology, Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Molecular Radiation Oncology, Xiangya Hospital, Central South University, Changsha, China.
Peng Y; Key Laboratory of Clinical Precision Pharmacy of Guangdong Higher Education Institutes, The First Affiliated Hospital, Guangdong Pharmaceutical University, 19 Nonglinxia Road, Yuexiu District, Guangzhou, Guangdong, China.; Clinical Pharmacy, The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangdong, China.
Gao Y; Department of Oncology, Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Molecular Radiation Oncology, Xiangya Hospital, Central South University, Changsha, China.
Fu Y; Department of Oncology, Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Molecular Radiation Oncology, Xiangya Hospital, Central South University, Changsha, China.
Qi X; Department of Oncology, Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Molecular Radiation Oncology, Xiangya Hospital, Central South University, Changsha, China.
Deng T; Key Laboratory of Clinical Precision Pharmacy of Guangdong Higher Education Institutes, The First Affiliated Hospital, Guangdong Pharmaceutical University, 19 Nonglinxia Road, Yuexiu District, Guangzhou, Guangdong, China.; Clinical Pharmacy, The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangdong, China.
Zhang S; Department of Oncology, Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Molecular Radiation Oncology, Xiangya Hospital, Central South University, Changsha, China.
Li X; Key Laboratory of Clinical Precision Pharmacy of Guangdong Higher Education Institutes, The First Affiliated Hospital, Guangdong Pharmaceutical University, 19 Nonglinxia Road, Yuexiu District, Guangzhou, Guangdong, China. .; Clinical Pharmacy, The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangdong, China. .; School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangdong, China. .; NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, Guangdong Pharmaceutical University, Guangdong, China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Aug 10; Vol. 42 (1), pp. 204. Date of Electronic Publication: 2023 Aug 10.
Typ publikacji:
Journal Article
MeSH Terms:
Mitochondrial Precursor Protein Import Complex Proteins*/metabolism
Prostatic Neoplasms, Castration-Resistant*/drug therapy
Prostatic Neoplasms, Castration-Resistant*/genetics
Prostatic Neoplasms, Castration-Resistant*/metabolism
Androgen Receptor Antagonists*/pharmacology
Humans ; Male ; Autophagy ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Phosphatidylinositol 3-Kinases ; Reactive Oxygen Species ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Animals
Czasopismo naukowe
Tytuł:
Elevated CHCHD4 orchestrates mitochondrial oxidative phosphorylation to disturb hypoxic pulmonary hypertension.
Autorzy:
Wang Y; Department of Cardiology, Changhai Hospital, Navy Medical University, 168 Changhai Road, Shanghai, 200433, People's Republic of China.
Zeng Z; Department of Cardiology, Changhai Hospital, Navy Medical University, 168 Changhai Road, Shanghai, 200433, People's Republic of China.
Zeng Z; Department of Vascular Surgery, Changhai Hospital, Navy Medical University, Shanghai, People's Republic of China.
Chu G; Department of Cardiology, Changhai Hospital, Navy Medical University, 168 Changhai Road, Shanghai, 200433, People's Republic of China. .
Shan X; Department of Cardiology, Changhai Hospital, Navy Medical University, 168 Changhai Road, Shanghai, 200433, People's Republic of China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Jul 12; Vol. 21 (1), pp. 464. Date of Electronic Publication: 2023 Jul 12.
Typ publikacji:
Journal Article
MeSH Terms:
Pulmonary Arterial Hypertension*/genetics
Mitochondrial Precursor Protein Import Complex Proteins*/genetics
Animals ; Rats ; Hypoxia/complications ; Mitochondrial Proteins ; Oxidative Phosphorylation ; Rats, Sprague-Dawley ; Vascular Remodeling
Czasopismo naukowe
Tytuł:
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Autorzy:
Koma R; Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa, Japan.
Shibaguchi T; Institute of Liberal Arts and Science, Kanazawa University, Kanazawa, Ishikawa, Japan.
Araiso Y; Department of Clinical Laboratory Science, Kanazawa University, Kanazawa, Ishikawa, Japan.
Yamada T; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nonaka Y; Institute of Liberal Arts and Science, Kanazawa University, Kanazawa, Ishikawa, Japan.
Jue T; Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA.
Masuda K; Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa, Japan.; Faculty of Human Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
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Źródło:
Physiological reports [Physiol Rep] 2023 Apr; Vol. 11 (7), pp. e15632.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mitochondrial Precursor Protein Import Complex Proteins*
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Membrane Transport Proteins/genetics ; Myoglobin/metabolism ; Membrane Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Mitochondria/metabolism ; Mitochondrial Membrane Transport Proteins/metabolism ; Carrier Proteins/metabolism ; Muscle Fibers, Skeletal/metabolism ; Protein Transport ; Mitochondrial Proteins/metabolism
Czasopismo naukowe
Tytuł:
TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer's Disease.
Autorzy:
Chen YC; Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Dementia Center, Taoyuan Chang Gung Memorial Hospital, Taoyuan 33378, Taiwan.
Chang SC; Department of Laboratory Medicine, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 33305, Taiwan.; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 33302, Taiwan.
Lee YS; Department of Biotechnology, Ming Chuan University, Taoyuan 33348, Taiwan.; Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
Ho WM; Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Dementia Center, Taoyuan Chang Gung Memorial Hospital, Taoyuan 33378, Taiwan.
Huang YH; Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Dementia Center, Taoyuan Chang Gung Memorial Hospital, Taoyuan 33378, Taiwan.
Wu YY; Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Dementia Center, Taoyuan Chang Gung Memorial Hospital, Taoyuan 33378, Taiwan.
Chu YC; Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Dementia Center, Taoyuan Chang Gung Memorial Hospital, Taoyuan 33378, Taiwan.
Wu KH; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 33302, Taiwan.
Wei LS; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 33302, Taiwan.
Wang HL; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan.; Healthy Aging Research Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan.
Chiu CC; Department of Laboratory Medicine, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 33305, Taiwan.; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 33302, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan.; Healthy Aging Research Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 17; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 17.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/pathology
Mitochondrial Precursor Protein Import Complex Proteins*/genetics
Neuroinflammatory Diseases*/genetics
Humans ; Inflammasomes/metabolism ; Interleukin-6/metabolism ; Microglia/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Genetic Variation
Czasopismo naukowe
Tytuł:
ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway.
Autorzy:
Hatori Y; Department of Pharmaceutics, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.
Kanda Y; Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.
Nonaka S; Department of Pharmacology, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.
Nakanishi H; Department of Pharmacology, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.
Kitazawa T; Department of Pharmaceutics, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.
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Źródło:
PloS one [PLoS One] 2022 Nov 29; Vol. 17 (11), pp. e0276823. Date of Electronic Publication: 2022 Nov 29 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagosomes*/genetics
Autophagosomes*/physiology
Lysosomes*/genetics
Lysosomes*/physiology
Proton-Translocating ATPases*/genetics
Proton-Translocating ATPases*/physiology
Parkinsonian Disorders*/genetics
Parkinsonian Disorders*/physiopathology
Mitochondrial Precursor Protein Import Complex Proteins*/physiology
Humans ; Membrane Proteins ; Mitochondria/genetics ; Mitochondria/physiology ; Mitochondrial Membranes/physiology ; Mitophagy/genetics ; Mitophagy/physiology
SCR Disease Name:
Kufor-Rakeb syndrome
Czasopismo naukowe
Tytuł:
Tom70-regulated mitochondrial biogenesis via TFAM improves hypoxia-induced dysfunction of pulmonary vascular endothelial cells and alleviates hypoxic pulmonary hypertension.
Autorzy:
Ma L; Department of Anesthesiology, Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Street, Xi'an, 710004, People's Republic of China. .
Wang Y; Department of Pathology, Xijing Hospital and School of Basic Medicine, Air Force Medical University, 169 Changle Western Street, Xi'an, 710032, People's Republic of China.
Li X; Department of Cardiology, Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, 28 Fuxing Street, Beijing, 100853, People's Republic of China.
Wang Z; Department of Basic Medicine, Graduate School, Chinese PLA General Hospital, 28 Fuxing Street, Beijing, 100853, People's Republic of China.
Zhang B; Department of Physiology and Pathophysiology, School of Basic Medicine, Air Force Medical University, 169 Changle Western Street, Xi'an, 710032, People's Republic of China.
Luo Y; Department of Physiology and Pathophysiology, School of Basic Medicine, Air Force Medical University, 169 Changle Western Street, Xi'an, 710032, People's Republic of China.
Wu Y; National Demonstration Center for Experimental Preclinical Medicine Education, Air Force Medical University, 169 Changle Western Street, Xi'an, 710032, People's Republic of China.
Li Z; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, 229 Taibai North Street, Xi'an, 710069, People's Republic of China. .
Niu W; Department of Physiology and Pathophysiology, School of Basic Medicine, Air Force Medical University, 169 Changle Western Street, Xi'an, 710032, People's Republic of China. .
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Źródło:
Respiratory research [Respir Res] 2023 Dec 13; Vol. 24 (1), pp. 310. Date of Electronic Publication: 2023 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Hypertension, Pulmonary*/genetics
Hypertension, Pulmonary*/metabolism
Animals ; Mice ; Endothelial Cells/metabolism ; Hypoxia/complications ; Lung/metabolism ; Mitochondrial Precursor Protein Import Complex Proteins ; Organelle Biogenesis
Czasopismo naukowe
Tytuł:
Endogenous TOM20 Proximity Labeling: A Swiss-Knife for the Study of Mitochondrial Proteins in Human Cells.
Autorzy:
Meurant S; URBC, Namur Research Institute for Life Sciences (Narilis), University of Namur (UNamur), 5000 Namur, Belgium.
Mauclet L; URBC, Namur Research Institute for Life Sciences (Narilis), University of Namur (UNamur), 5000 Namur, Belgium.
Dieu M; Mass Spectrometry Platform (MaSUN), Namur Research Institute for Life Sciences (Narilis), University of Namur (UNamur), 5000 Namur, Belgium.
Arnould T; URBC, Namur Research Institute for Life Sciences (Narilis), University of Namur (UNamur), 5000 Namur, Belgium.
Eyckerman S; VIB-UGent Center for Medical Biotechnology, VIB, 9000 Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Renard P; URBC, Namur Research Institute for Life Sciences (Narilis), University of Namur (UNamur), 5000 Namur, Belgium.; Mass Spectrometry Platform (MaSUN), Namur Research Institute for Life Sciences (Narilis), University of Namur (UNamur), 5000 Namur, Belgium.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 31; Vol. 24 (11). Date of Electronic Publication: 2023 May 31.
Typ publikacji:
Journal Article
MeSH Terms:
Mitochondrial Membranes*/metabolism
Mitochondrial Proteins*/genetics
Mitochondrial Proteins*/metabolism
Animals ; Humans ; Mammals/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Membrane Transport Proteins/metabolism ; Mitochondrial Precursor Protein Import Complex Proteins
Czasopismo naukowe
Tytuł:
Familial 5.29 Mb deletion in chromosome Xq22.1-q22.3 with a normal phenotype: a rare pedigree and literature review.
Autorzy:
Xu HH; Prenatal Diagnosis Center, Taizhou Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. .; Medical Research Center, Taizhou Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. .
Zhang Y; Medical Research Center, Taizhou Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
He ZH; Medical Research Center, Taizhou Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Di XH; Medical Research Center, Taizhou Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Pan FY; Medical Research Center, Taizhou Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Shi WW; Prenatal Diagnosis Center, Taizhou Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. .; Medical Research Center, Taizhou Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. .
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Źródło:
BMC medical genomics [BMC Med Genomics] 2023 May 22; Vol. 16 (1), pp. 111. Date of Electronic Publication: 2023 May 22.
Typ publikacji:
Review; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Copy Number Variations*
Chromosome Aberrations*
Pregnancy ; Female ; Humans ; Pedigree ; Phenotype ; Chromosome Deletion ; Chromosomes ; Mitochondrial Precursor Protein Import Complex Proteins
Czasopismo naukowe
Tytuł:
APOE ɛ4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages.
Autorzy:
Kulminski AM; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
Jain-Washburn E; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
Philipp I; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
He L; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
Loika Y; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
Loiko E; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
Bagley O; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
Ukraintseva S; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
Yashin A; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
Arbeev K; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
Stallard E; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, USA.
Schupf N; Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, New York, USA.
Christensen K; Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Southern Denmark University, Odense, Denmark.
Culminskaya I; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.
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Źródło:
Aging cell [Aging Cell] 2022 Dec; Vol. 21 (12), pp. e13730. Date of Electronic Publication: 2022 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Apolipoproteins E*/genetics
Alzheimer Disease*/genetics
Humans ; Middle Aged ; Aged ; Alleles ; Genotype ; Heterozygote ; Apolipoprotein E4/genetics ; Mitochondrial Precursor Protein Import Complex Proteins
Czasopismo naukowe
Tytuł:
TIMM8A is associated with dysfunction of immune cell in BRCA and UCEC for predicting anti-PD-L1 therapy efficacy.
Autorzy:
Zhu X; Department of Dermatology, The Fourth Hospital of Changsha, Changsha, Hunan, 410000, China.; Hunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, and Xiangya School of Stomatology, Central South University, Changsha, Hunan, 410008, China.
Yuan Z; Department of Dermatology, The Fourth Hospital of Changsha, Changsha, Hunan, 410000, China.; Hunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, and Xiangya School of Stomatology, Central South University, Changsha, Hunan, 410008, China.
Cheng S; Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China.
Wang H; Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China.
Liao Y; Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China.
Zhou D; Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China.
Wu Z; Department of Dermatology, The Fourth Hospital of Changsha, Changsha, Hunan, 410000, China. .
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Źródło:
World journal of surgical oncology [World J Surg Oncol] 2022 Oct 07; Vol. 20 (1), pp. 336. Date of Electronic Publication: 2022 Oct 07.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Carcinoma, Endometrioid*
Antibodies/*immunology
B7-H1 Antigen/*immunology
Biomarkers, Tumor/genetics ; Female ; Humans ; Membrane Transport Proteins ; Mitochondrial Precursor Protein Import Complex Proteins ; Mitochondrial Proteins ; Prognosis
Czasopismo naukowe
Tytuł:
Identification and analysis of deletion breakpoints in four Mohr-Tranebjærg syndrome (MTS) patients.
Autorzy:
Rendtorff ND; Department of Clinical Genetics, Center of Diagnostics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. .
Karstensen HG; Department of Clinical Genetics, Center of Diagnostics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Lodahl M; Department of Clinical Genetics, Center of Diagnostics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Tolmie J; Clinical Genetics Service, Laboratory Medicine Building, Southern General Hospital, Glasgow, Scotland.
McWilliam C; Clinical Genetics, Human Genetics Unit, Ninewells Hospital, Dundee, Scotland.
Bak M; Department of Clinical Genetics, Center of Diagnostics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Wilhelm Johannsen Center for Functional Genome Research, University of Copenhagen, Copenhagen, Denmark.; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Tommerup N; Wilhelm Johannsen Center for Functional Genome Research, University of Copenhagen, Copenhagen, Denmark.; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Nazaryan-Petersen L; Wilhelm Johannsen Center for Functional Genome Research, University of Copenhagen, Copenhagen, Denmark.; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.; Center for Genomic Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Kunst H; Department of Otorhinolaryngology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Otorhinolaryngology, Maastricht University Medical Center, Maastricht, The Netherlands.
Wong M; Department of Allergy and Immunology, The Children's Hospital at Westmead, Sydney, Australia.
Joss S; West of Scotland Centre for Genomic Medicine, Queen Elizabeth University Hospital, Glasgow, UK.
Carelli V; IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, Bologna, Italy.; Unit of Neurology, Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Tranebjærg L; Department of Clinical Genetics, Center of Diagnostics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. .; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. .
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Źródło:
Scientific reports [Sci Rep] 2022 Sep 02; Vol. 12 (1), pp. 14959. Date of Electronic Publication: 2022 Sep 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Deaf-Blind Disorders*/genetics
Dystonia*/genetics
Intellectual Disability*/genetics
Optic Atrophy*/genetics
Humans ; Membrane Transport Proteins/genetics ; Mitochondrial Precursor Protein Import Complex Proteins
SCR Disease Name:
Mohr-Tranebjaerg syndrome
Czasopismo naukowe
Tytuł:
Spatiotemporal stop-and-go dynamics of the mitochondrial TOM core complex correlates with channel activity.
Autorzy:
Wang S; Department of Biophysics, Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, Stuttgart, Germany.
Findeisen L; Department of Biophysics, Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, Stuttgart, Germany.
Leptihn S; Zhejiang University-University of Edinburgh (ZJU-UoE) Institute, Zhejiang University, Zhejiang, China.
Wallace MI; Department of Chemistry, King's College London, Britannia House, London, UK.
Hörning M; Department of Biobased Materials, Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, Stuttgart, Germany. .
Nussberger S; Department of Biophysics, Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, Stuttgart, Germany. .
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Źródło:
Communications biology [Commun Biol] 2022 May 17; Vol. 5 (1), pp. 471. Date of Electronic Publication: 2022 May 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mitochondrial Membrane Transport Proteins*/metabolism
Saccharomyces cerevisiae Proteins*/metabolism
Hydrogels ; Membrane Proteins/metabolism ; Membrane Transport Proteins/metabolism ; Mitochondria/metabolism ; Mitochondrial Precursor Protein Import Complex Proteins
Czasopismo naukowe
Tytuł:
Tourniquet-induced lower limb ischemia/reperfusion reduces mitochondrial function by decreasing mitochondrial biogenesis in acute kidney injury in mice.
Autorzy:
Packialakshmi B; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.; The Henry Jackson M. Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Stewart IJ; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Burmeister DM; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Feng Y; Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
McDaniel DP; Biomedical Instrumentation Center, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Chung KK; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Zhou X; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
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Źródło:
Physiological reports [Physiol Rep] 2022 Feb; Vol. 10 (3), pp. e15181.
Typ publikacji:
Journal Article
MeSH Terms:
Mitophagy*
Organelle Biogenesis*
Acute Kidney Injury/*therapy
Hindlimb/*blood supply
Ischemia/*metabolism
Ischemic Preconditioning/*methods
Acute Kidney Injury/metabolism ; Animals ; HSP27 Heat-Shock Proteins/metabolism ; Ischemic Preconditioning/instrumentation ; Male ; Mice ; Mitochondria, Muscle/metabolism ; Mitochondrial Precursor Protein Import Complex Proteins/metabolism ; Oxidative Stress ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Protein Kinases/metabolism ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł:
Effects of PNPLA3, TM6SF2 and SAMM50 on the development and severity of non-alcoholic fatty liver disease in children.
Autorzy:
Lee KJ; Department of Pediatrics, Hallym University College of Medicine, Chuncheon, South Korea.
Moon JS; Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea.
Kim NY; Hallym Institute of Translational Genomics & Bioinformatics, Hallym University Medical Center, Anyang, Republic of Korea.
Ko JS; Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea.
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Źródło:
Pediatric obesity [Pediatr Obes] 2022 Feb; Vol. 17 (2), pp. e12852. Date of Electronic Publication: 2021 Sep 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Membrane Proteins*/genetics
Non-alcoholic Fatty Liver Disease*/complications
Non-alcoholic Fatty Liver Disease*/epidemiology
Non-alcoholic Fatty Liver Disease*/genetics
Acyltransferases/*genetics
Mitochondrial Precursor Protein Import Complex Proteins/*genetics
Phospholipases A2, Calcium-Independent/*genetics
Adolescent ; Child ; Genetic Predisposition to Disease ; Genotype ; Humans ; Lipase/genetics ; Liver ; Male ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł:
Mitochondria shed their outer membrane in response to infection-induced stress.
Autorzy:
Li X; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Straub J; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Medeiros TC; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Mehra C; Max Planck Institute for Biology of Ageing, Cologne, Germany.
den Brave F; Institute of Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, Bonn, Germany.
Peker E; Institute of Biochemistry, University of Cologne, Cologne, Germany.
Atanassov I; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Stillger K; Institute of Biochemistry, University of Cologne, Cologne, Germany.
Michaelis JB; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany.
Burbridge E; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland.; Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Adrain C; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland.; Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Münch C; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany.
Riemer J; Institute of Biochemistry, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Becker T; Institute of Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, Bonn, Germany.
Pernas LF; Max Planck Institute for Biology of Ageing, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Jan 14; Vol. 375 (6577), pp. eabi4343. Date of Electronic Publication: 2022 Jan 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mitochondrial Membranes/*physiology
Mitochondrial Precursor Protein Import Complex Proteins/*metabolism
Protozoan Proteins/*metabolism
Toxoplasma/*physiology
Animals ; Cell Line ; GTP Phosphohydrolases/metabolism ; Humans ; Intracellular Membranes/physiology ; Intracellular Membranes/ultrastructure ; Mice ; Mitochondrial Membrane Transport Proteins/metabolism ; Mitochondrial Membranes/ultrastructure ; Mitochondrial Proteins/metabolism ; Protein Binding ; Stress, Physiological ; Toxoplasma/growth & development ; Toxoplasma/ultrastructure ; Toxoplasmosis/parasitology ; Vacuoles/physiology ; Vacuoles/ultrastructure
Czasopismo naukowe
Tytuł:
Enhanced Expression of microRNA-1273g-3p Contributes to Alzheimer's Disease Pathogenesis by Regulating the Expression of Mitochondrial Genes.
Autorzy:
Kim SH; Cell Logistics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Choi KY; Gwangju Alzheimer's Disease and Related Dementia Cohort Research Center, Chosun University, Gwangju 61452, Korea.
Park Y; Cell Logistics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
McLean C; Department of Pathology, The Alfred Hospital, Melbourne, VIC 3004, Australia.
Park J; Cell Logistics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Lee JH; Department of Biochemistry and Cell Biology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
Lee KH; Department of Pathology, Chonnam National University Research Institute of Medical Science, BioMedical Sciences Graduate Program, Chonnam National University Hwasun Hospital and Medical School, Gwangju 58128, Korea.
Kim BC; Department of Neurology, Chonnam National University Medical School, Gwangju 61469, Korea.
Huh YH; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Lee KH; Gwangju Alzheimer's Disease and Related Dementia Cohort Research Center, Chosun University, Gwangju 61452, Korea.; Department of Biomedical Science, Chosun University, Gwangju 61452, Korea.; Aging Neuroscience Research Group, Korea Brain Research Institute, Daegu 41062, Korea.
Song WK; Cell Logistics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
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Źródło:
Cells [Cells] 2021 Oct 09; Vol. 10 (10). Date of Electronic Publication: 2021 Oct 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation*
Genes, Mitochondrial*
Alzheimer Disease/*genetics
MicroRNAs/*genetics
Aged ; Aged, 80 and over ; Alzheimer Disease/blood ; Alzheimer Disease/cerebrospinal fluid ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/metabolism ; Aspartic Acid Endopeptidases/metabolism ; Cell Line, Tumor ; Down-Regulation/genetics ; Female ; Hippocampus/pathology ; Humans ; Male ; MicroRNAs/blood ; MicroRNAs/cerebrospinal fluid ; MicroRNAs/metabolism ; Mitochondria/metabolism ; Mitochondrial Precursor Protein Import Complex Proteins/genetics ; Mitochondrial Precursor Protein Import Complex Proteins/metabolism ; Models, Biological ; Oxidative Stress/genetics ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł:
Relation between ORF8a and the mitochondrial protein TOM70 in SARS-CoV-2 infection.
Autorzy:
Zandi M; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran.
Soltani S; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran.
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Źródło:
Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2021 Dec; Vol. 233 (4), pp. e13712. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji:
Editorial
MeSH Terms:
COVID-19*/genetics
Mitochondrial Precursor Protein Import Complex Proteins/*genetics
Viral Proteins/*genetics
Humans ; Mitochondria ; Protein Binding ; SARS-CoV-2
Opinia redakcyjna

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