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Tytuł :
RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
Autorzy :
Li T; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Wang X; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Ju E; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
da Silva SR; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Chen L; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Zhang X; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Wei S; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Gao SJ; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 16; Vol. 12 (1), pp. 1055. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Proteolysis*/drug effects
Ubiquitination*/drug effects
Carcinogenesis/*metabolism
Carcinogenesis/*pathology
Intracellular Signaling Peptides and Proteins/*metabolism
Mechanistic Target of Rapamycin Complex 1/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; Arginine/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Disease Progression ; Female ; Intercellular Signaling Peptides and Proteins/pharmacology ; Kinetics ; Lysine/metabolism ; Mice, Nude ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism
Czasopismo naukowe
Tytuł :
Extracellular BMP1 is the major proteinase for COOH-terminal proteolysis of type I procollagen in lung fibroblasts.
Autorzy :
N'Diaye EN; Department of Discovery Immunology, Genentech, South San Francisco, California.
Cook R; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California.
Wang H; Department of Antibody Engineering, Genentech, South San Francisco, California.
Wu P; Department of Structural Biology, Genentech, South San Francisco, California.
LaCanna R; Department of Discovery Immunology, Genentech, South San Francisco, California.
Wu C; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California.
Ye Z; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California.
Seshasayee D; Department of Antibody Engineering, Genentech, South San Francisco, California.
Hazen M; Department of Antibody Engineering, Genentech, South San Francisco, California.
Lin W; Department of Antibody Engineering, Genentech, South San Francisco, California.
Tyagi T; Department of Antibody Engineering, Genentech, South San Francisco, California.
Hotzel I; Department of Antibody Engineering, Genentech, South San Francisco, California.
Tam L; Department of Molecular Biology, Genentech, South San Francisco, California.
Newman R; Department of Molecular Biology, Genentech, South San Francisco, California.
Roose-Girma M; Department of Molecular Biology, Genentech, South San Francisco, California.
Wolters PJ; Department of Medicine, University of California, San Francisco, California.
Ding N; Department of Discovery Immunology, Genentech, South San Francisco, California.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2021 Feb 01; Vol. 320 (2), pp. C162-C174. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article
MeSH Terms :
Proteolysis*/drug effects
Bone Morphogenetic Protein 1/*metabolism
Extracellular Fluid/*metabolism
Fibroblasts/*metabolism
Lung/*metabolism
Peptide Fragments/*metabolism
Procollagen/*metabolism
Amino Acid Sequence ; Animals ; Bone Morphogenetic Protein 1/antagonists & inhibitors ; Bone Morphogenetic Protein 1/genetics ; CHO Cells ; Cricetinae ; Cricetulus ; Extracellular Fluid/drug effects ; Fibroblasts/drug effects ; HEK293 Cells ; Humans ; Lung/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Organ Culture Techniques ; Organoids ; Oxadiazoles/pharmacology ; Peptide Fragments/genetics ; Peptide Hydrolases/genetics ; Peptide Hydrolases/metabolism ; Procollagen/genetics ; Protease Inhibitors/pharmacology ; Rabbits
Czasopismo naukowe
Tytuł :
Limited Proteolysis and Gel Electrophoresis in the Presence of Metal Cations: Au(III)-binding Luminescent Domain in Serum Albumins.
Autorzy :
Dixon JM; Department of Physics and Optical Science, Center for Biomedical Engineering & Science, The University of North Carolina.
Egusa S; Department of Physics and Optical Science, Center for Biomedical Engineering & Science, The University of North Carolina; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2021 Jan 21 (167). Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Luminescence*
Proteolysis*
Electrophoresis/*methods
Gold/*metabolism
Serum Albumin, Bovine/*chemistry
Serum Albumin, Bovine/*metabolism
Animals ; Binding Sites ; Cations ; Cattle ; Crystallography, X-Ray ; Fluorescence ; Gels ; Hydrogen-Ion Concentration ; Protein Domains ; Trypsin/metabolism
Czasopismo naukowe
Tytuł :
Control of Capsid Transformations during Reovirus Entry.
Autorzy :
Gummersheimer SL; Department of Biology, Indiana University, Bloomington, IN 47405, USA.
Snyder AJ; Department of Biology, Indiana University, Bloomington, IN 47405, USA.
Danthi P; Department of Biology, Indiana University, Bloomington, IN 47405, USA.
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Źródło :
Viruses [Viruses] 2021 Jan 21; Vol. 13 (2). Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Proteolysis*
Virus Internalization*
Capsid Proteins/*metabolism
Orthoreovirus, Mammalian/*physiology
Reoviridae Infections/*virology
Virion/*physiology
Animals ; Capsid Proteins/genetics ; Cell Line ; Mice ; Orthoreovirus, Mammalian/genetics ; Protein Domains ; Reoviridae Infections/genetics ; Virion/genetics
Czasopismo naukowe
Tytuł :
Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex.
Autorzy :
Rizzolo K; Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada.; Dewpoint Therapeutics, 6 Tide Street, Boston, MA, 02210, USA.
Yu AYH; Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada.; Pfizer Inc., 401 N Middletown Rd, Pearl River, NY, 10965, USA.
Ologbenla A; Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada.
Kim SR; Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada.
Zhu H; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan.
Ishimori K; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan.; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, Hokkaido, 060-0810, Japan.
Thibault G; Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada.; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.
Leung E; Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada.
Zhang YW; Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada.
Teng M; Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada.
Haniszewski M; Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada.
Miah N; Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada.
Phanse S; Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada.; The Donnelly Centre, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Department of Biochemistry, University of Regina, Regina, Saskatchewan, S4S 0A2, Canada.
Minic Z; Department of Biochemistry, University of Regina, Regina, Saskatchewan, S4S 0A2, Canada.; Department of Chemistry and Biomolecular Science, University of Ottawa, John L. Holmes, Mass Spectrometry Facility, Ottawa, ON, K1N 1A2, Canada.
Lee S; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Caballero JD; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, M5S 3G5, Canada.
Babu M; Department of Biochemistry, University of Regina, Regina, Saskatchewan, S4S 0A2, Canada.
Tsai FTF; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA.
Saio T; Institute of Advanced Medical Sciences, Tokushima University, Tokushima, 770-8503, Japan.
Houry WA; Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada. .; Department of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 12; Vol. 12 (1), pp. 281. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Endopeptidase Clp/*metabolism
Molecular Chaperones/*metabolism
Binding Sites ; Endopeptidase Clp/chemistry ; Escherichia coli/genetics ; Escherichia coli Proteins ; Gene Deletion ; Genome, Bacterial ; Magnetic Resonance Spectroscopy ; Models, Biological ; Models, Molecular ; Mutagenesis ; Peptides/metabolism ; Peptidylprolyl Isomerase ; Phylogeny ; Protein Binding ; Protein Domains ; Protein Interaction Mapping ; Protein Multimerization ; Ribosomes/metabolism ; Substrate Specificity ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Self-assembly synthes is of trypsin-immobilized monolithic microreactor for fast and efficient proteolysis.
Autorzy :
Zhong C; Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
Yang B; Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
Huang W; Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
Huang H; Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
Zhang S; Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
Yan X; Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
Lu Q; Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
Chen Z; Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
Lin Z; Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Jan 04; Vol. 1635, pp. 461742. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Bioreactors*
Proteolysis*
Proteomics/*methods
Trypsin/*metabolism
Blood Proteins/metabolism ; Enzymes, Immobilized/chemistry ; Humans ; Mass Spectrometry ; Peptides/metabolism
Czasopismo naukowe
Tytuł :
Influence of proteolytic enzyme treatment on the changes in volatile compounds and odors of beef longissimus dorsi.
Autorzy :
Zhao D; Key Laboratory of Meat Processing, MOA, Key Laboratory of Meat Processing and Quality Control, MOE; Jiang Synergetic Innovation Center of Meat Production, Processing and Quality Control, Nanjing Agricultural University, Nanjing 210095, PR China.
Li H; Key Laboratory of Meat Processing, MOA, Key Laboratory of Meat Processing and Quality Control, MOE; Jiang Synergetic Innovation Center of Meat Production, Processing and Quality Control, Nanjing Agricultural University, Nanjing 210095, PR China.
Huang M; Key Laboratory of Meat Processing, MOA, Key Laboratory of Meat Processing and Quality Control, MOE; Jiang Synergetic Innovation Center of Meat Production, Processing and Quality Control, Nanjing Agricultural University, Nanjing 210095, PR China.
Wang T; Key Laboratory of Meat Processing, MOA, Key Laboratory of Meat Processing and Quality Control, MOE; Jiang Synergetic Innovation Center of Meat Production, Processing and Quality Control, Nanjing Agricultural University, Nanjing 210095, PR China.
Hu Y; Key Laboratory of Meat Processing, MOA, Key Laboratory of Meat Processing and Quality Control, MOE; Jiang Synergetic Innovation Center of Meat Production, Processing and Quality Control, Nanjing Agricultural University, Nanjing 210095, PR China.
Wang L; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Xu D; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Mao S; Center Testing International Pinbiao (Jiangsu) Certification Technology Co., Ltd, Nanjing, PR China.
Li C; Key Laboratory of Meat Processing, MOA, Key Laboratory of Meat Processing and Quality Control, MOE; Jiang Synergetic Innovation Center of Meat Production, Processing and Quality Control, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address: .
Zhou G; Key Laboratory of Meat Processing, MOA, Key Laboratory of Meat Processing and Quality Control, MOE; Jiang Synergetic Innovation Center of Meat Production, Processing and Quality Control, Nanjing Agricultural University, Nanjing 210095, PR China.
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Źródło :
Food chemistry [Food Chem] 2020 Dec 15; Vol. 333, pp. 127549. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Odorants*
Proteolysis*
Muscle Proteins/*metabolism
Peptide Hydrolases/*metabolism
Red Meat/*analysis
Volatile Organic Compounds/*metabolism
Amino Acids/metabolism ; Animals ; Cattle ; Hydrolysis ; Taste
Czasopismo naukowe
Tytuł :
Targeting Cancer Cells via N-degron-based PROTACs.
Autorzy :
Eldeeb MA; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Zorca CE; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Fahlman RP; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
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Źródło :
Endocrinology [Endocrinology] 2020 Dec 01; Vol. 161 (12).
Typ publikacji :
Journal Article
MeSH Terms :
Proteolysis*
Autophagy/*physiology
Neoplasms/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Proteins/*metabolism
Humans
Czasopismo naukowe
Tytuł :
Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo .
Autorzy :
Kellermeyer R; Department of Biology/MS 314, University of Nevada, 1664 North Virginia Street, Reno, NV 89557, USA.
Heydman LM; Department of Biology/MS 314, University of Nevada, 1664 North Virginia Street, Reno, NV 89557, USA.
Gillis T; Department of Biology/MS 314, University of Nevada, 1664 North Virginia Street, Reno, NV 89557, USA.
Mastick GS; Department of Biology/MS 314, University of Nevada, 1664 North Virginia Street, Reno, NV 89557, USA.
Song M; Department of Biology/MS 314, University of Nevada, 1664 North Virginia Street, Reno, NV 89557, USA.
Kidd T; Department of Biology/MS 314, University of Nevada, 1664 North Virginia Street, Reno, NV 89557, USA .
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Źródło :
Development (Cambridge, England) [Development] 2020 Oct 29; Vol. 147 (20). Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Proteolysis*
Axons/*metabolism
Bone Morphogenetic Protein 1/*metabolism
Drosophila Proteins/*metabolism
Drosophila melanogaster/*metabolism
Nerve Tissue Proteins/*metabolism
Amino Acid Sequence ; Animals ; Axon Guidance ; Cell Membrane/metabolism ; Drosophila Proteins/chemistry ; Epistasis, Genetic ; Extracellular Space/metabolism ; Models, Biological ; Mutation/genetics ; Nerve Tissue Proteins/chemistry ; Phenotype ; Protein Binding
Czasopismo naukowe
Tytuł :
Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation.
Autorzy :
Nagareddy B; Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York, USA.
Khan A; Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York, USA.
Kim H; Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York, USA .; Stony Brook Cancer Center, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Oct 02; Vol. 295 (40), pp. 13887-13901. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Ubiquitination*
Fanconi Anemia Complementation Group D2 Protein/*metabolism
Fanconi Anemia Complementation Group Proteins/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Ubiquitin/*metabolism
Acetylation ; Cell Line, Tumor ; Fanconi Anemia Complementation Group D2 Protein/genetics ; Fanconi Anemia Complementation Group Proteins/genetics ; Humans ; Proteasome Endopeptidase Complex/genetics ; Ubiquitin/genetics
Czasopismo naukowe
Tytuł :
Effect of ultrasound on proteolysis and the formation of volatile compounds in dry fermented sausages.
Autorzy :
de Lima Alves L; Universidade Federal de Santa Maria - UFSM, Av. Roraima, 1000, Cidade Universitária, Bairro Camobi, CEP 97105-900 Santa Maria, RS, Brazil.
Donadel JZ; Universidade Federal de Santa Maria - UFSM, Av. Roraima, 1000, Cidade Universitária, Bairro Camobi, CEP 97105-900 Santa Maria, RS, Brazil.
Athayde DR; Universidade Federal de Santa Maria - UFSM, Av. Roraima, 1000, Cidade Universitária, Bairro Camobi, CEP 97105-900 Santa Maria, RS, Brazil.
da Silva MS; Universidade Federal de Santa Maria - UFSM, Av. Roraima, 1000, Cidade Universitária, Bairro Camobi, CEP 97105-900 Santa Maria, RS, Brazil.
Klein B; Universidade Federal de Santa Maria - UFSM, Av. Roraima, 1000, Cidade Universitária, Bairro Camobi, CEP 97105-900 Santa Maria, RS, Brazil.
Fagundes MB; Universidade Federal de Santa Maria - UFSM, Av. Roraima, 1000, Cidade Universitária, Bairro Camobi, CEP 97105-900 Santa Maria, RS, Brazil.
de Menezes CR; Universidade Federal de Santa Maria - UFSM, Av. Roraima, 1000, Cidade Universitária, Bairro Camobi, CEP 97105-900 Santa Maria, RS, Brazil.
Barin JS; Universidade Federal de Santa Maria - UFSM, Av. Roraima, 1000, Cidade Universitária, Bairro Camobi, CEP 97105-900 Santa Maria, RS, Brazil.
Campagnol PCB; Universidade Federal de Santa Maria - UFSM, Av. Roraima, 1000, Cidade Universitária, Bairro Camobi, CEP 97105-900 Santa Maria, RS, Brazil.
Wagner R; Universidade Federal de Santa Maria - UFSM, Av. Roraima, 1000, Cidade Universitária, Bairro Camobi, CEP 97105-900 Santa Maria, RS, Brazil.
Cichoski AJ; Universidade Federal de Santa Maria - UFSM, Av. Roraima, 1000, Cidade Universitária, Bairro Camobi, CEP 97105-900 Santa Maria, RS, Brazil. Electronic address: .
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Źródło :
Ultrasonics sonochemistry [Ultrason Sonochem] 2020 Oct; Vol. 67, pp. 105161. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Fermentation*
Meat Products*
Proteolysis*
Sonication*
Volatile Organic Compounds/*metabolism
Czasopismo naukowe
Tytuł :
Accelerated whole-body protein catabolism in subjects with type 2 Diabetes Mellitus and albuminuria.
Autorzy :
Zanetti M; Metabolism Division, Department of Medicine, University of Padova, Padova, Italy.; DSM, University of Trieste, Trieste, Italy.
Barazzoni R; Metabolism Division, Department of Medicine, University of Padova, Padova, Italy.; DSM, University of Trieste, Trieste, Italy.
Kiwanuka E; Metabolism Division, Department of Medicine, University of Padova, Padova, Italy.
Vettore M; Metabolism Division, Department of Medicine, University of Padova, Padova, Italy.
Vedovato M; Metabolism Division, Department of Medicine, University of Padova, Padova, Italy.
Tessari P; Metabolism Division, Department of Medicine, University of Padova, Padova, Italy.
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Źródło :
PloS one [PLoS One] 2020 Dec 17; Vol. 15 (12), pp. e0243638. Date of Electronic Publication: 2020 Dec 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Albuminuria/*complications
Diabetes Mellitus, Type 2/*complications
Adult ; Albuminuria/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Female ; Humans ; Male ; Middle Aged ; Phenylalanine/metabolism ; Protein Biosynthesis
Czasopismo naukowe
Tytuł :
Proteolysis-Responsive Rolling Circle Transcription Assay Enabling Femtomolar Sensitivity Detection of a Target Protease Biomarker.
Autorzy :
Luo X; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082, P. R. China.
Zhao J; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082, P. R. China.
Xie X; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082, P. R. China.
Liu F; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082, P. R. China.
Zeng P; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082, P. R. China.
Lei C; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082, P. R. China.
Nie Z; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082, P. R. China.
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Źródło :
Analytical chemistry [Anal Chem] 2020 Dec 15; Vol. 92 (24), pp. 16314-16321. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Limit of Detection*
Proteolysis*
Matrix Metalloproteinase 2/*metabolism
Nucleic Acid Amplification Techniques/*methods
Biomarkers/metabolism ; Humans
Czasopismo naukowe
Tytuł :
The applicability of forensic time since death estimation methods for buried bodies in advanced decomposition stages.
Autorzy :
Pittner S; Dept. of Forensic Medicine, University of Salzburg, Salzburg, Austria.
Bugelli V; Dept. of Medicine and Health Sciences, University of Florence, Florence, Italy.
Benbow ME; Dept. of Entomology, Michigan State University, East Lansing, Michigan, United States of America.; Dept. of Osteopathic Medical Specialties, Michigan State University, East Lansing, Michigan, United States of America.; Ecology, Evolutionary Biology and Behavior Program, Michigan State University, East Lansing, Michigan, United States of America.
Ehrenfellner B; Dept. of Biosciences, University of Salzburg, Salzburg, Austria.
Zissler A; Dept. of Biosciences, University of Salzburg, Salzburg, Austria.
Campobasso CP; Dept. of Experimental Medicine, University L. Vanvitelli of Campania, Naples, Italy.
Oostra RJ; Dept. of Medical Biology, Amsterdam UMC - location AMC, University of Amsterdam, Amsterdam, The Netherlands.
Aalders MCG; Dept. of Biomedical Engineering and Physics, Amsterdam UMC - location AMC, University of Amsterdam, Amsterdam, The Netherlands.
Zehner R; Institute of Legal Medicine, Goethe-University Frankfurt, Frankfurt, Germany.
Lutz L; Institute of Legal Medicine, Goethe-University Frankfurt, Frankfurt, Germany.
Monticelli FC; Dept. of Forensic Medicine, University of Salzburg, Salzburg, Austria.
Staufer C; Dept. of Forensic Medicine, University of Salzburg, Salzburg, Austria.
Helm K; Dept. of Forensic Medicine, University of Salzburg, Salzburg, Austria.
Pinchi V; Dept. of Medicine and Health Sciences, University of Florence, Florence, Italy.
Receveur JP; Dept. of Entomology, Michigan State University, East Lansing, Michigan, United States of America.
Geißenberger J; Dept. of Biosciences, University of Salzburg, Salzburg, Austria.
Steinbacher P; Dept. of Biosciences, University of Salzburg, Salzburg, Austria.
Amendt J; Institute of Legal Medicine, Goethe-University Frankfurt, Frankfurt, Germany.
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Źródło :
PloS one [PLoS One] 2020 Dec 09; Vol. 15 (12), pp. e0243395. Date of Electronic Publication: 2020 Dec 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Forensic Medicine/*methods
Forensic Pathology/*methods
Muscle, Skeletal/*chemistry
Animals ; Burial ; Death ; Exhumation ; Humans ; Insecta/physiology ; Microbiota ; Models, Animal ; Postmortem Changes
Czasopismo naukowe
Tytuł :
The Arg/N-degron pathway targets transcription factors and regulates specific genes.
Autorzy :
Vu TTM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Mitchell DC; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
Varshavsky A; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 08; Vol. 117 (49), pp. 31094-31104. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Proteolysis*
Activating Transcription Factor 3/*genetics
Homeodomain Proteins/*genetics
Receptors, Glucocorticoid/*genetics
Antigens, Neoplasm/genetics ; Eye Proteins/genetics ; Gene Expression Regulation/genetics ; Gene Knockout Techniques ; HEK293 Cells ; Humans ; Intermediate Filaments/genetics ; Mass Spectrometry ; Microfilament Proteins/genetics ; Monocarboxylic Acid Transporters/genetics ; Neoplasm Proteins/genetics ; Protein Binding/genetics ; RNA-Seq ; Receptors, Adrenergic, beta-2/genetics ; Signal Transduction/genetics ; Transcription Factors/genetics ; Ubiquitin/genetics ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł :
Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation.
Autorzy :
Deol KK; Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Crowe SO; Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Du J; Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Bisbee HA; Molecular & Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Guenette RG; Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Strieter ER; Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA; Molecular & Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA 01003, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Dec 03; Vol. 80 (5), pp. 796-809.e9. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Proteolysis*
Intracellular Signaling Peptides and Proteins/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Ubiquitin/*metabolism
Ubiquitin Thiolesterase/*metabolism
HEK293 Cells ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Proteasome Endopeptidase Complex/genetics ; Ubiquitin/genetics ; Ubiquitin Thiolesterase/genetics
Czasopismo naukowe
Tytuł :
TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
Autorzy :
Sun N; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Jiang L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Ye M; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Wang Y; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Wang G; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Wan X; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Zhao Y; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Wen X; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Liang L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Ma S; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Liu L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Bu Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Chen H; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China. .
Li C; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China. .
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Źródło :
Protein & cell [Protein Cell] 2020 Dec; Vol. 11 (12), pp. 894-914. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Apoptosis Regulatory Proteins/*immunology
Influenza A Virus, H1N1 Subtype/*immunology
Orthomyxoviridae Infections/*immunology
TNF Receptor-Associated Factor 3/*immunology
Ubiquitination/*immunology
Viral Proteins/*immunology
A549 Cells ; Animals ; Apoptosis Regulatory Proteins/genetics ; DEAD Box Protein 58/genetics ; DEAD Box Protein 58/immunology ; Dogs ; HEK293 Cells ; Humans ; Influenza A Virus, H1N1 Subtype/genetics ; Madin Darby Canine Kidney Cells ; Mice ; Mice, Knockout ; Orthomyxoviridae Infections/genetics ; Orthomyxoviridae Infections/pathology ; RAW 264.7 Cells ; Signal Transduction/genetics ; Signal Transduction/immunology ; THP-1 Cells ; TNF Receptor-Associated Factor 3/genetics ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Electron-Based Dissociation Is Needed for O-Glycopeptides Derived from OpeRATOR Proteolysis.
Autorzy :
Riley NM; Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, California, United States.
Malaker SA; Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, California, United States.
Bertozzi CR; Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, California, United States.; Howard Hughes Medical Institute, Stanford, California, United States.
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Źródło :
Analytical chemistry [Anal Chem] 2020 Nov 17; Vol. 92 (22), pp. 14878-14884. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Electrons*
Proteolysis*
Glycopeptides/*metabolism
Peptide Hydrolases/*metabolism
Akkermansia/enzymology ; Amino Acid Sequence ; Peptide Hydrolases/chemistry ; Tandem Mass Spectrometry
SCR Organism :
Akkermansia muciniphila
Czasopismo naukowe
Tytuł :
High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds using HiBiT CRISPR Cell Lines.
Autorzy :
Riching KM; Promega Corporation.
Mahan SD; Promega Corporation.
Urh M; Promega Corporation.
Daniels DL; Promega Corporation; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2020 Nov 09 (165). Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
High-Throughput Screening Assays*
Proteolysis*
Clustered Regularly Interspaced Short Palindromic Repeats/*genetics
Cell Adhesion ; Cell Line ; Cell Survival ; Fluorescence ; HEK293 Cells ; Humans ; Kinetics ; Ubiquitination
Czasopismo naukowe
Tytuł :
IRAK4 degrader to take on innate immunity.
Autorzy :
Mullard A; Ottawa, Ontario, Canada.
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Źródło :
Nature biotechnology [Nat Biotechnol] 2020 Nov; Vol. 38 (11), pp. 1221-1223.
Typ publikacji :
Wiadomości
MeSH Terms :
Immunity, Innate*
Proteolysis*
Animals ; Clinical Trials as Topic ; Humans ; Interleukin-1 Receptor-Associated Kinases/chemistry ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Signal Transduction ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/metabolism
Periodyk

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