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Wyszukujesz frazę ""quetiapine"" wg kryterium: Temat


Tytuł :
Severe Adverse Drug Reactions to Quetiapine in Two Patients Carrying CYP2D6 *4 Variants: A Case Report.
Autorzy :
Stäuble CK; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.; Pharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, 4001 Basel, Switzerland.; Institute of Hospital Pharmacy, Solothurner Spitäler, 4600 Olten, Switzerland.
Lampert ML; Pharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, 4001 Basel, Switzerland.; Institute of Hospital Pharmacy, Solothurner Spitäler, 4600 Olten, Switzerland.
Mikoteit T; Psychiatric Services Solothurn, Solothurner Spitäler and Department of Medicine, University of Basel, 4503 Solothurn, Switzerland.
Hatzinger M; Psychiatric Services Solothurn, Solothurner Spitäler and Department of Medicine, University of Basel, 4503 Solothurn, Switzerland.
Hersberger KE; Pharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, 4001 Basel, Switzerland.
Meyer Zu Schwabedissen HE; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 17; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Case Reports
MeSH Terms :
Pharmacogenomic Variants*
Cytochrome P-450 CYP2D6/*genetics
Drug-Related Side Effects and Adverse Reactions/*diagnosis
Drug-Related Side Effects and Adverse Reactions/*etiology
Quetiapine Fumarate/*adverse effects
Alleles ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/chemistry ; Antipsychotic Agents/metabolism ; Cytochrome P-450 CYP2D6/metabolism ; Drug-Related Side Effects and Adverse Reactions/metabolism ; Genetic Association Studies ; Genetic Variation ; Genotype ; Humans ; Male ; Middle Aged ; Pharmacogenetics ; Phenotype ; Quetiapine Fumarate/administration & dosage ; Quetiapine Fumarate/chemistry ; Quetiapine Fumarate/metabolism ; Severity of Illness Index
Raport
Tytuł :
Trends and characteristics of extra-medical use of quetiapine among people who regularly inject drugs in Australia, 2011-2018.
Autorzy :
Sutherland R; National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia. Electronic address: .
Jayathilake R; National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia.
Peacock A; National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia; School of Psychology, School of Medicine, University of Tasmania, Sandy Bay, TAS, 7005, Australia.
Dietze P; Burnet Institute, 85 Commercial Rd, Melbourne, VIC, 3004, Australia.
Bruno R; National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia; School of Psychology, School of Medicine, University of Tasmania, Sandy Bay, TAS, 7005, Australia.
Reddel S; Victorian Counselling and Psychology Services, 23 Swanston St, Melbourne, VIC, 3000, Australia; La Trobe Community Health Service, 31 Mason St, Warragul, VIC, 3820, Australia; Budja Budja Aboriginal Cooperative Health Service, 20-22 Grampians Rd, Halls Gap, VIC, 3381, Australia.
Gisev N; National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia.
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Źródło :
Drug and alcohol dependence [Drug Alcohol Depend] 2021 Apr 01; Vol. 221, pp. 108636. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzodiazepines*
Illicit Drugs*
Quetiapine Fumarate*
Drug Users/*statistics & numerical data
Substance Abuse, Intravenous/*epidemiology
Adult ; Australia/epidemiology ; Female ; Humans ; Linear Models ; Longitudinal Studies ; Male ; Middle Aged ; Odds Ratio ; Substance Abuse, Intravenous/psychology
Czasopismo naukowe
Tytuł :
Influence of Plasdone S630 Ultra-an Improved Copovidone on the Processability and Oxidative Degradation of Quetiapine Fumarate Amorphous Solid Dispersions Prepared via Hot-Melt Extrusion Technique.
Autorzy :
Butreddy A; Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Oxford, Mississippi, 38677, USA.
Sarabu S; Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Oxford, Mississippi, 38677, USA.
Bandari S; Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Oxford, Mississippi, 38677, USA.
Batra A; Ashland Specialty Ingredients, Wilmington, Delaware, 19808, USA.
Lawal K; Ashland Specialty Ingredients, Wilmington, Delaware, 19808, USA.
Chen NN; Ashland Specialty Ingredients, Wilmington, Delaware, 19808, USA.
Bi V; Ashland Specialty Ingredients, Wilmington, Delaware, 19808, USA.
Durig T; Ashland Specialty Ingredients, Wilmington, Delaware, 19808, USA.
Repka MA; Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Oxford, Mississippi, 38677, USA. .; Pii Center for Pharmaceutical Technology, The University of Mississippi, University, Oxford, Mississippi, 38677, USA. .
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2021 Jun 28; Vol. 22 (5), pp. 196. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article
MeSH Terms :
Hot Melt Extrusion Technology/*methods
Pharmaceutic Aids/*chemical synthesis
Povidone/*chemical synthesis
Pyrrolidines/*chemical synthesis
Quetiapine Fumarate/*chemical synthesis
Vinyl Compounds/*chemical synthesis
Calorimetry, Differential Scanning/methods ; Chemistry, Pharmaceutical/methods ; Drug Compounding/methods ; Hot Temperature ; Oxidation-Reduction ; Pharmaceutic Aids/pharmacokinetics ; Povidone/pharmacokinetics ; Pyrrolidines/pharmacokinetics ; Quetiapine Fumarate/pharmacokinetics ; Solubility ; Spectroscopy, Fourier Transform Infrared/methods ; Vinyl Compounds/pharmacokinetics
Czasopismo naukowe
Tytuł :
Successful diagnosis and treatment of pulmonary aspergillosis-related malignant catatonia using propofol and quetiapine: A case report.
Autorzy :
Nomura K; Department of Emergency Medicine, Sapporo Medical University Hospital, Sapporo-shi.
Sakawaki S; Department of Emergency Medicine, Hakodate Municipal Hospital, Hakodate-shi.
Sakawaki E; Department of Emergency Medicine, Hakodate Municipal Hospital, Hakodate-shi.
Yamaoka A; Department of Neurosurgery, Sunagawa City Medical Center, Sunagawa-shi.
Aisaka W; Department of Emergency Medicine, Sapporo Medical University Hospital, Sapporo-shi.
Okamoto H; Department of Emergency Medicine, Teine Keijinkai Hospital, Sapporo-shi, Hokkaido, Japan.
Takeyama Y; Department of Emergency Medicine, Hakodate Municipal Hospital, Hakodate-shi.
Uemura S; Department of Emergency Medicine, Sapporo Medical University Hospital, Sapporo-shi.
Narimatsu E; Department of Emergency Medicine, Sapporo Medical University Hospital, Sapporo-shi.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 May 14; Vol. 100 (19), pp. e25967.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Catatonia/*complications
Catatonia/*drug therapy
Hypnotics and Sedatives/*therapeutic use
Propofol/*therapeutic use
Pulmonary Aspergillosis/*complications
Quetiapine Fumarate/*therapeutic use
Catatonia/diagnosis ; Diagnosis, Differential ; Female ; Humans ; Hypnotics and Sedatives/administration & dosage ; Middle Aged ; Neuroleptic Malignant Syndrome/diagnosis ; Propofol/administration & dosage ; Quetiapine Fumarate/administration & dosage ; Renal Insufficiency/complications ; Schizophrenia/complications
Czasopismo naukowe
Tytuł :
Quetiapine and other antipsychotics combined with opioids in legal autopsy cases: A random finding or cause of fatal outcome?
Autorzy :
Andersen FD; Department of Forensic Medicine, Aarhus University, Aarhus, Denmark.
Simonsen U; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Andersen CU; Department of Forensic Medicine, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark.
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Źródło :
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2021 Jan; Vol. 128 (1), pp. 66-79. Date of Electronic Publication: 2020 Sep 06.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Forensic Toxicology*
Analgesics, Opioid/*adverse effects
Antipsychotic Agents/*adverse effects
Drug Overdose/*mortality
Opioid-Related Disorders/*mortality
Quetiapine Fumarate/*adverse effects
Adolescent ; Adult ; Analgesics, Opioid/pharmacokinetics ; Animals ; Antipsychotic Agents/pharmacokinetics ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/mortality ; Arrhythmias, Cardiac/physiopathology ; Autopsy ; Cause of Death ; Consciousness/drug effects ; Drug Interactions ; Drug Overdose/diagnosis ; Drug Overdose/physiopathology ; Female ; Humans ; Hypotension/chemically induced ; Hypotension/mortality ; Hypotension/physiopathology ; Male ; Methadone/adverse effects ; Middle Aged ; Morphine/adverse effects ; Opioid-Related Disorders/complications ; Opioid-Related Disorders/diagnosis ; Opioid-Related Disorders/physiopathology ; Quetiapine Fumarate/pharmacokinetics ; Respiratory Insufficiency/chemically induced ; Respiratory Insufficiency/mortality ; Respiratory Insufficiency/physiopathology ; Risk Assessment ; Risk Factors
Czasopismo naukowe
Tytuł :
A case of extended-release Quetiapine causing recurrent low-grade fevers.
Autorzy :
Puthran R; Institute of Mental Health, Singapore. Electronic address: .
Lai D; Institute of Mental Health, Singapore.
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Źródło :
Psychiatry research [Psychiatry Res] 2021 Jan; Vol. 295, pp. 113583. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Antipsychotic Agents/*adverse effects
Delayed-Action Preparations/*adverse effects
Fever/*chemically induced
Psychotic Disorders/*drug therapy
Quetiapine Fumarate/*adverse effects
Adult ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/therapeutic use ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/therapeutic use ; Female ; Humans ; Neuroleptic Malignant Syndrome ; Quetiapine Fumarate/administration & dosage ; Treatment Outcome
Raport
Tytuł :
Effects of Quetiapine on Neural Tube Development in the Early Stage of Chicken Embryos.
Autorzy :
Ovalioglu TC; Bakirkoy Research and Training Hospital for Neurology, Neurosurgery and Psychiatry, Department of Neurosurgery, Istanbul, Turkey.
Canaz G
Arslan S
Ovalioglu AO
Sar M
Aydin AE
Emel E
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Źródło :
Turkish neurosurgery [Turk Neurosurg] 2021; Vol. 31 (1), pp. 137-141.
Typ publikacji :
Journal Article
MeSH Terms :
Antipsychotic Agents/*administration & dosage
Embryonic Development/*drug effects
Neural Tube/*drug effects
Neural Tube/*embryology
Quetiapine Fumarate/*administration & dosage
Animals ; Antipsychotic Agents/adverse effects ; Chick Embryo ; Chickens ; Embryonic Development/physiology ; Neural Tube Defects/chemically induced ; Neural Tube Defects/diagnosis ; Quetiapine Fumarate/adverse effects
Czasopismo naukowe
Tytuł :
Quetiapine and novel PDE10A inhibitors potentiate the anti-BuChE activity of donepezil.
Autorzy :
Sikora J; Laboratory of Bioanalysis, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, Lodz, Poland.
Podsiedlik M; Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, Lodz, Poland.
Pietras T; Department of Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
Kosmalski M; Department of Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
Matłoka M; Research and Development Department, Celon Pharma S.A, Łomianki, Poland.
Moszczyński-Petkowski R; Research and Development Department, Celon Pharma S.A, Łomianki, Poland.
Wieczorek M; Research and Development Department, Celon Pharma S.A, Łomianki, Poland.
Markowicz-Piasecka M; Laboratory of Bioanalysis, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, Lodz, Poland.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1743-1750.
Typ publikacji :
Journal Article
MeSH Terms :
Antipsychotic Agents/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Donepezil/*pharmacology
Phosphodiesterase Inhibitors/*pharmacology
Quetiapine Fumarate/*pharmacology
Acetylcholinesterase/metabolism ; Antipsychotic Agents/chemical synthesis ; Antipsychotic Agents/chemistry ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Donepezil/chemical synthesis ; Donepezil/chemistry ; Dose-Response Relationship, Drug ; Healthy Volunteers ; Humans ; Molecular Structure ; Phosphodiesterase Inhibitors/chemical synthesis ; Phosphodiesterase Inhibitors/chemistry ; Phosphoric Diester Hydrolases/metabolism ; Quetiapine Fumarate/chemical synthesis ; Quetiapine Fumarate/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Quantification of neurotransmitters in microdialysate samples following quetiapine dosing to schizophrenia phenotyped rats using a validated LC-MS/MS method.
Autorzy :
Carreño F; Pharmacokinetics and PK/PD Modeling Laboratory, Pharmaceutical Sciences Graduate Program, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Av. Ipiranga, 2759, 90610-000 Porto Alegre, RS, Brazil.
Helfer VE; Pharmacokinetics and PK/PD Modeling Laboratory, Pharmaceutical Sciences Graduate Program, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Av. Ipiranga, 2759, 90610-000 Porto Alegre, RS, Brazil.
Staudt KJ; Pharmacokinetics and PK/PD Modeling Laboratory, Pharmaceutical Sciences Graduate Program, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Av. Ipiranga, 2759, 90610-000 Porto Alegre, RS, Brazil.
Olivo LB; Pharmacokinetics and PK/PD Modeling Laboratory, Pharmaceutical Sciences Graduate Program, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Av. Ipiranga, 2759, 90610-000 Porto Alegre, RS, Brazil.
Barreto F; Federal Laboratory of Animal and Plant Health and Inspection - LFDA/RS, Estrada Ponta Grossa, 3036, 91780-580 Porto Alegre, RS, Brazil.
Herrmann AP; Pharmacology and Therapeutics Graduate Program, Basic Health Science Institute, Federal University of Rio Grande do Sul, Av. Sarmento Leite, 500, 90050-170 Porto Alegre, Rio Grande do Sul, RS, Brazil.
Rates SMK; Experimental Psychopharmacology Laboratory, Pharmaceutical Sciences Graduate Program, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Av. Ipiranga, 2759, 90610-000 Porto Alegre, RS, Brazil.
Dalla Costa T; Pharmacokinetics and PK/PD Modeling Laboratory, Pharmaceutical Sciences Graduate Program, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Av. Ipiranga, 2759, 90610-000 Porto Alegre, RS, Brazil. Electronic address: .
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2020 Oct 15; Vol. 1155, pp. 122282. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Chemistry*/drug effects
Brain Chemistry*/physiology
Quetiapine Fumarate*/administration & dosage
Quetiapine Fumarate*/pharmacokinetics
Quetiapine Fumarate*/pharmacology
Chromatography, Liquid/*methods
Neurotransmitter Agents/*analysis
Schizophrenia/*metabolism
Animals ; Disease Models, Animal ; Linear Models ; Male ; Microdialysis ; Neurotransmitter Agents/metabolism ; Rats ; Rats, Wistar ; Reproducibility of Results ; Sensitivity and Specificity ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł :
Unmetabolized quetiapine exerts an in vitro effect on innate immune cells by modulating inflammatory response and neutrophil extracellular trap formation.
Autorzy :
Turra BO; Graduate Program of Pharmacology, Universidade Federal Santa Maria, Santa Maria, RS, Brazil.
Barbisan F; Graduate Program in Gerontology, Universidade Federal Santa Maria, Santa Maria, RS, Brazil.
Azzolin VF; Graduate Program in Gerontology, Universidade Federal Santa Maria, Santa Maria, RS, Brazil.
Teixeira CF; Graduate Program of Pharmacology, Universidade Federal Santa Maria, Santa Maria, RS, Brazil.
Flores T; Graduate Program of Pharmacology, Universidade Federal Santa Maria, Santa Maria, RS, Brazil.
Braun LE; Biogenomic Laboratory, Universidade Federal Santa Maria, Santa Maria, RS, Brazil.
de Oliveira Nerys DA; Biogenomic Laboratory, Universidade Federal Santa Maria, Santa Maria, RS, Brazil.
Rissi VB; Biotechnology and Animal Reproduction Laboratory, Universidade Federal Santa Maria, Santa Maria, RS, Brazil.
de Oliveira Alves A; Graduate Program of Pharmacology, Universidade Federal Santa Maria, Santa Maria, RS, Brazil.
Assmann CE; Graduate Program of Biological Sciences, Universidade Federal Santa Maria, Santa Maria, RS, Brazil.
da Cruz Jung IE; Graduate Program of Pharmacology, Universidade Federal Santa Maria, Santa Maria, RS, Brazil.
Marques LPS; Graduate Program in Gerontology, Universidade Federal Santa Maria, Santa Maria, RS, Brazil.
da Cruz IBM; Graduate Program of Pharmacology, Universidade Federal Santa Maria, Santa Maria, RS, Brazil; Graduate Program in Gerontology, Universidade Federal Santa Maria, Santa Maria, RS, Brazil. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Nov; Vol. 131, pp. 110497. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Extracellular Traps/*drug effects
Macrophages/*drug effects
Neutrophils/*drug effects
Quetiapine Fumarate/*pharmacology
Animals ; Cytokines/genetics ; Humans ; Immunity, Innate/drug effects ; Macrophages/physiology ; Mice ; Neutrophils/physiology ; Quetiapine Fumarate/metabolism ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
The impact of quetiapine on the brain lipidome in a cuprizone-induced mouse model of schizophrenia.
Autorzy :
Zhou CH; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China; Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, China.
Xue SS; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China; Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, China.
Xue F; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Liu L; Institute of Neuroscience, Fourth Military Medical University, Xi'an, 710032, China.
Liu JC; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Ma QR; Department of Pediatrics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China; Department of Human Anatomy and Histology and Embryology, Basic Medical College, Ningxia Medical University, 750004, China.
Qin JH; State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Tan QR; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Wang HN; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: .
Peng ZW; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China; Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Nov; Vol. 131, pp. 110707. Date of Electronic Publication: 2020 Sep 06.
Typ publikacji :
Journal Article
MeSH Terms :
Lipidomics*
Brain/*drug effects
Cuprizone/*toxicity
Quetiapine Fumarate/*pharmacology
Schizophrenia/*drug therapy
Animals ; Brain/metabolism ; Cognition/drug effects ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Quetiapine Fumarate/therapeutic use ; Schizophrenia/chemically induced
Czasopismo naukowe
Tytuł :
Quetiapine augmentation of prolonged exposure therapy in veterans with PTSD and a history of mild traumatic brain injury: design and methodology of a pilot study.
Autorzy :
Baig MR; Mental Health, South Texas Veterans Healthcare System, 116 A, 7400 Merton Minter Blvd, San Antonio, TX, 78229, USA. .; Polytrauma Rehabilitation Center, South Texas Veterans Healthcare System, San Antonio, TX, USA. .; Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. .
Beck RD; Mental Health, South Texas Veterans Healthcare System, 116 A, 7400 Merton Minter Blvd, San Antonio, TX, 78229, USA.; Polytrauma Rehabilitation Center, South Texas Veterans Healthcare System, San Antonio, TX, USA.
Wilson JL; Mental Health, South Texas Veterans Healthcare System, 116 A, 7400 Merton Minter Blvd, San Antonio, TX, 78229, USA.; Polytrauma Rehabilitation Center, South Texas Veterans Healthcare System, San Antonio, TX, USA.
Lemmer JA; Mental Health, South Texas Veterans Healthcare System, 116 A, 7400 Merton Minter Blvd, San Antonio, TX, 78229, USA.; Polytrauma Rehabilitation Center, South Texas Veterans Healthcare System, San Antonio, TX, USA.
Meraj A; Mental Health, South Texas Veterans Healthcare System, 116 A, 7400 Merton Minter Blvd, San Antonio, TX, 78229, USA.
Meyer EC; Department of Veterans Affairs VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.; Central Texas Veterans Healthcare System, Waco, TX, USA.; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA.
Mintz J; Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Peterson AL; Mental Health, South Texas Veterans Healthcare System, 116 A, 7400 Merton Minter Blvd, San Antonio, TX, 78229, USA.; Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Department of Psychology, University of Texas at San Antonio, San Antonio, USA.
Roache JD; Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
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Źródło :
Military Medical Research [Mil Med Res] 2020 Oct 08; Vol. 7 (1), pp. 46. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Brain Concussion/*drug therapy
Quetiapine Fumarate/*pharmacology
Stress Disorders, Post-Traumatic/*drug therapy
Veterans/*psychology
Brain Concussion/physiopathology ; Humans ; Implosive Therapy/methods ; Pilot Projects ; Quetiapine Fumarate/therapeutic use ; Stress Disorders, Post-Traumatic/physiopathology ; Texas ; Treatment Outcome ; Veterans/statistics & numerical data
Czasopismo naukowe
Tytuł :
Post mortem tissue distribution of quetiapine in forensic autopsies.
Autorzy :
Breivik H; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. Electronic address: .
Frost J; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Clinical Pharmacology, St. Olav University Hospital, NO-7006, Trondheim, Norway.
Løkken TN; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Slørdal L; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Clinical Pharmacology, St. Olav University Hospital, NO-7006, Trondheim, Norway.
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Źródło :
Forensic science international [Forensic Sci Int] 2020 Oct; Vol. 315, pp. 110413. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article
MeSH Terms :
Postmortem Changes*
Antipsychotic Agents/*pharmacokinetics
Quetiapine Fumarate/*pharmacokinetics
Adult ; Aged ; Antipsychotic Agents/analysis ; Brain Chemistry ; Female ; Forensic Toxicology ; Humans ; Liver/chemistry ; Male ; Middle Aged ; Muscle, Skeletal/chemistry ; Quetiapine Fumarate/analysis ; Substance-Related Disorders/mortality ; Young Adult
Czasopismo naukowe
Tytuł :
Semi-Mechanistic Pharmacokinetic Modeling of Lipid Core Nanocapsules: Understanding Quetiapine Plasma and Brain Disposition in a Neurodevelopmental Animal Model of Schizophrenia.
Autorzy :
Carreño F; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia (F.C., V.E.H., K.J.S., L.B.O., K.P., S.S.G., S.M.K.R., T.D.C.), Centro de Reprodução e Experimentação de Animais de Laboratório, Instituto de Ciências Básicas da Saúde (F.S.M.), and Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde (A.P.H.), Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Pharmacometrics and Systems Pharmacology Research Unit, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (I.T.); and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (I.T.).
Helfer VE; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia (F.C., V.E.H., K.J.S., L.B.O., K.P., S.S.G., S.M.K.R., T.D.C.), Centro de Reprodução e Experimentação de Animais de Laboratório, Instituto de Ciências Básicas da Saúde (F.S.M.), and Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde (A.P.H.), Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Pharmacometrics and Systems Pharmacology Research Unit, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (I.T.); and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (I.T.).
Staudt KJ; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia (F.C., V.E.H., K.J.S., L.B.O., K.P., S.S.G., S.M.K.R., T.D.C.), Centro de Reprodução e Experimentação de Animais de Laboratório, Instituto de Ciências Básicas da Saúde (F.S.M.), and Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde (A.P.H.), Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Pharmacometrics and Systems Pharmacology Research Unit, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (I.T.); and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (I.T.).
Olivo LB; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia (F.C., V.E.H., K.J.S., L.B.O., K.P., S.S.G., S.M.K.R., T.D.C.), Centro de Reprodução e Experimentação de Animais de Laboratório, Instituto de Ciências Básicas da Saúde (F.S.M.), and Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde (A.P.H.), Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Pharmacometrics and Systems Pharmacology Research Unit, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (I.T.); and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (I.T.).
Paese K; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia (F.C., V.E.H., K.J.S., L.B.O., K.P., S.S.G., S.M.K.R., T.D.C.), Centro de Reprodução e Experimentação de Animais de Laboratório, Instituto de Ciências Básicas da Saúde (F.S.M.), and Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde (A.P.H.), Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Pharmacometrics and Systems Pharmacology Research Unit, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (I.T.); and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (I.T.).
Meyer FS; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia (F.C., V.E.H., K.J.S., L.B.O., K.P., S.S.G., S.M.K.R., T.D.C.), Centro de Reprodução e Experimentação de Animais de Laboratório, Instituto de Ciências Básicas da Saúde (F.S.M.), and Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde (A.P.H.), Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Pharmacometrics and Systems Pharmacology Research Unit, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (I.T.); and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (I.T.).
Herrmann AP; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia (F.C., V.E.H., K.J.S., L.B.O., K.P., S.S.G., S.M.K.R., T.D.C.), Centro de Reprodução e Experimentação de Animais de Laboratório, Instituto de Ciências Básicas da Saúde (F.S.M.), and Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde (A.P.H.), Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Pharmacometrics and Systems Pharmacology Research Unit, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (I.T.); and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (I.T.).
Guterres SS; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia (F.C., V.E.H., K.J.S., L.B.O., K.P., S.S.G., S.M.K.R., T.D.C.), Centro de Reprodução e Experimentação de Animais de Laboratório, Instituto de Ciências Básicas da Saúde (F.S.M.), and Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde (A.P.H.), Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Pharmacometrics and Systems Pharmacology Research Unit, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (I.T.); and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (I.T.).
Kuze Rates SM; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia (F.C., V.E.H., K.J.S., L.B.O., K.P., S.S.G., S.M.K.R., T.D.C.), Centro de Reprodução e Experimentação de Animais de Laboratório, Instituto de Ciências Básicas da Saúde (F.S.M.), and Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde (A.P.H.), Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Pharmacometrics and Systems Pharmacology Research Unit, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (I.T.); and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (I.T.).
Trocóniz I; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia (F.C., V.E.H., K.J.S., L.B.O., K.P., S.S.G., S.M.K.R., T.D.C.), Centro de Reprodução e Experimentação de Animais de Laboratório, Instituto de Ciências Básicas da Saúde (F.S.M.), and Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde (A.P.H.), Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Pharmacometrics and Systems Pharmacology Research Unit, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (I.T.); and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (I.T.).
Dalla Costa T; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia (F.C., V.E.H., K.J.S., L.B.O., K.P., S.S.G., S.M.K.R., T.D.C.), Centro de Reprodução e Experimentação de Animais de Laboratório, Instituto de Ciências Básicas da Saúde (F.S.M.), and Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde (A.P.H.), Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Pharmacometrics and Systems Pharmacology Research Unit, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (I.T.); and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (I.T.) .
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Oct; Vol. 375 (1), pp. 49-58. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Biological*
Antipsychotic Agents/*pharmacokinetics
Brain/*drug effects
Drug Carriers/*pharmacokinetics
Nanocapsules/*administration & dosage
Quetiapine Fumarate/*pharmacokinetics
Schizophrenia/*drug therapy
Animals ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/blood ; Antipsychotic Agents/pharmacology ; Brain/metabolism ; Disease Models, Animal ; Drug Carriers/administration & dosage ; Female ; Male ; Microdialysis ; Quetiapine Fumarate/administration & dosage ; Quetiapine Fumarate/blood ; Quetiapine Fumarate/pharmacology ; Rats ; Rats, Wistar ; Reflex, Startle/drug effects ; Schizophrenia/blood ; Schizophrenia/metabolism
Czasopismo naukowe
Tytuł :
Optimization and in vivo evaluation of quetiapine-loaded transdermal drug delivery system for the treatment of schizophrenia.
Autorzy :
Agrawal MB; Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, India.
Patel MM; Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, India.
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Źródło :
Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2020 Nov; Vol. 46 (11), pp. 1819-1831. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article
MeSH Terms :
Quetiapine Fumarate*/metabolism
Schizophrenia*/drug therapy
Administration, Cutaneous ; Drug Delivery Systems ; Humans ; Skin/metabolism ; Transdermal Patch
Czasopismo naukowe
Tytuł :
A 3-year prospective study on the metabolic effect of aripiprazole, quetiapine and ziprasidone: A pragmatic clinical trial in first episode psychosis patients.
Autorzy :
Vázquez-Bourgon J; Department of Psychiatry, University Hospital Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Avda.Valdecilla s/n, Santander 39008, Spain; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Spain; Department of Medicine and Psychiatry, School of Medicine, University of Cantabria, Santander, Spain. Electronic address: .
Ibáñez Alario M; Department of Psychiatry, University Hospital Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Avda.Valdecilla s/n, Santander 39008, Spain.
Mayoral-van Son J; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Spain; Department of Psychiatry, School of Medicine, University Hospital Virgen del Rocio-IBiS, Sevilla, Spain.
Gómez Revuelta M; Department of Psychiatry, University Hospital Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Avda.Valdecilla s/n, Santander 39008, Spain; Department of Medicine and Psychiatry, School of Medicine, University of Cantabria, Santander, Spain.
Ayesa Arriola R; Department of Psychiatry, University Hospital Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Avda.Valdecilla s/n, Santander 39008, Spain; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Spain.
Juncal Ruiz M; Department of Medicine and Psychiatry, School of Medicine, University of Cantabria, Santander, Spain; Department of Psychiatry, Sierrallana Hospital, IDIVAL, Torrelavega, Spain.
Ortiz-García de la Foz V; Department of Psychiatry, University Hospital Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Avda.Valdecilla s/n, Santander 39008, Spain.
Crespo Facorro B; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Spain; Department of Psychiatry, School of Medicine, University Hospital Virgen del Rocio-IBiS, Sevilla, Spain.
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Źródło :
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2020 Oct; Vol. 39, pp. 46-55. Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article; Pragmatic Clinical Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antipsychotic Agents/*therapeutic use
Aripiprazole/*therapeutic use
Piperazines/*therapeutic use
Quetiapine Fumarate/*therapeutic use
Schizophrenia/*drug therapy
Schizophrenia/*metabolism
Thiazoles/*therapeutic use
Adult ; Antipsychotic Agents/adverse effects ; Aripiprazole/adverse effects ; Energy Metabolism/drug effects ; Energy Metabolism/physiology ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; Piperazines/adverse effects ; Prospective Studies ; Psychotic Disorders/drug therapy ; Psychotic Disorders/metabolism ; Quetiapine Fumarate/adverse effects ; Thiazoles/adverse effects ; Time Factors ; Weight Gain/drug effects ; Weight Gain/physiology ; Young Adult
Czasopismo naukowe
Tytuł :
Oral quetiapine treatment results in time-dependent alterations of recognition memory and brain-derived neurotrophic factor-related signaling molecules in the hippocampus of rats.
Autorzy :
Poddar I; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, United States of America.
Callahan PM; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, United States of America; Small Animal Behavior Core, Augusta University, Augusta, GA 30912, United States of America.
Hernandez CM; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, United States of America.
Pillai A; Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, Augusta, GA 30912, United States of America.
Yang X; Department of Pharmaceutical and Biomedical Sciences, University of Georgia College of Pharmacy, Athens, GA 30602, United States of America.
Bartlett MG; Department of Pharmaceutical and Biomedical Sciences, University of Georgia College of Pharmacy, Athens, GA 30602, United States of America.
Terry AV Jr; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, United States of America; Small Animal Behavior Core, Augusta University, Augusta, GA 30912, United States of America. Electronic address: .
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Źródło :
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2020 Oct; Vol. 197, pp. 172999. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antipsychotic Agents/*pharmacology
Brain-Derived Neurotrophic Factor/*metabolism
Hippocampus/*metabolism
Quetiapine Fumarate/*pharmacology
Recognition, Psychology/*drug effects
Signal Transduction/*drug effects
Administration, Oral ; Animals ; Antipsychotic Agents/administration & dosage ; Behavior, Animal/drug effects ; Catalepsy ; Cognition/drug effects ; Cyclic AMP Response Element-Binding Protein/metabolism ; Male ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Quetiapine Fumarate/administration & dosage ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Pharmacology Update: Quetiapine-Has It Become a Novel Drug of Abuse?
Autorzy :
Lorman WJ; William J. Lorman, JD, PhD, MSN, PMHNP/CNS-BC, CARN-AP, Drexel University, Philadelphia, Pennsylvania.
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Źródło :
Journal of addictions nursing [J Addict Nurs] 2020 Oct/Dec; Vol. 31 (4), pp. 312-313.
Typ publikacji :
Journal Article
MeSH Terms :
Prescription Drug Misuse*
Quetiapine Fumarate*/therapeutic use
Substance-Related Disorders*
Humans
Czasopismo naukowe
Tytuł :
Approach to Evaluating QT Prolongation of Quetiapine Fumarate in Late Stage of Clinical Development Using Concentration-QTc Modeling and Simulation in Japanese Patients With Bipolar Disorder.
Autorzy :
Fukushi R; Astellas Pharma Inc, Tokyo, Japan. Electronic address: .
Nomura Y; Astellas Pharma Inc, Tokyo, Japan.
Katashima M; Astellas Pharma Inc, Tokyo, Japan.
Komatsu K; Astellas Pharma Inc, Tokyo, Japan.
Sato Y; Astellas Pharma Inc, Tsukuba, Japan.
Takada A; Astellas Pharma Global Development Inc, Northbrook, IL, USA.
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Źródło :
Clinical therapeutics [Clin Ther] 2020 Aug; Vol. 42 (8), pp. 1483-1493.e1. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Biological*
Bipolar Disorder/*drug therapy
Long QT Syndrome/*chemically induced
Quetiapine Fumarate/*adverse effects
Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group ; Bipolar Disorder/metabolism ; Bipolar Disorder/physiopathology ; Computer Simulation ; Cross-Over Studies ; Delayed-Action Preparations/adverse effects ; Delayed-Action Preparations/pharmacokinetics ; Double-Blind Method ; Electrocardiography/drug effects ; Female ; Heart Rate/drug effects ; Humans ; Long QT Syndrome/blood ; Long QT Syndrome/metabolism ; Long QT Syndrome/physiopathology ; Male ; Middle Aged ; Quetiapine Fumarate/blood ; Quetiapine Fumarate/pharmacokinetics ; Young Adult
Czasopismo naukowe

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