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Tytuł :
孤儿受体TR3 抑制蛋白精氨酸甲基转移酶(PRMT1)诱导的甲基化
Index Terms :
PRMT1; TR3; H4 R3; 甲基化
PRMT1; TR3; H4 R3; methylation
thesis
Tytuły dodatkowe :
Orphan receptor TR3 attenuates the PRMT1-induced methylation
URL :
http://dspace.xmu.edu.cn:8080/dspace/handle/2288/47259
http://210.34.4.28/opac/openlink.php?strText=19325&doctype=ALL&strSearchType=callno
http://210.34.4.28/opac/openlink.php?strText=19325&doctype=ALL&strSearchType=callno
Zasób elektroniczny
Tytuł :
The structures of T6, T3R3 and R6 bovine insulin: combining X-ray diffraction and absorption spectroscopy
Index Terms :
The crystal structures of three conformations, T6, T3R3 and R6, of bovine insulin were solved at 1.40, 1.30 and 1.80 Å resolution, respectively. All conformations crystallized in space group R3. In contrast to the T6 and T3R3 structures, different conformations of the N-terminal B-chain residue PheB1 were observed in the R6 insulin structure, resulting in an eightfold doubling of the unit-cell volume upon cooling. The zinc coordination in each conformation was studied by X-ray absorption spectroscopy (XAS), including both EXAFS and XANES. Zinc adopts a tetrahedral coordination in all R3 sites and an octahedral coordination in T3 sites. The coordination distances were refined from XAS with a standard deviation of <0.01 Å. In contrast to the distances determined from the medium-resolution crystal structures, the XAS results were in good agreement with similar coordination geometries found in small molecules, as well as in other high-resolution insulin structures. As the radiation dose for XRD experiments is two orders of magnitude higher compared with that of XAS experiments, the single crystals were exposed to a higher degree of radiation damage that affected the zinc coordination in the T3 sites in particular. Furthermore, XANES spectra for the zinc sites in T6 and R6 insulin were successfully calculated using finite difference methods and the bond distances and angles were optimized from a quantitative XANES analysis.
URL :
http://orbit.dtu.dk/en/publications/the-structures-of-t6-t3r3-and-r6-bovine-insulin-combining-xray-diffraction-and-absorption-spectroscopy(f30dc89f-fb49-4eb8-a066-a916c1f0c14a).html
Zasób elektroniczny
Tytuł :
Mercury Oxidation over Selective Catalytic Reduction (SCR) Catalysts - Ph.d. thesis Karin Madsen
Index Terms :
Den vanadium-baserede SCR (Selective Catalytic Reduction) katalysator anvendes typisk til reduktion af NOx-forbindelser. SCR reaktorer viser sig desuden ogs°a at fremme oxidationen af elementært kviksølv Hg0 til Hg2+ i røggasser fra kulfyrede kraftværker. Dette er hensigtsmæssigt, da Hg2+ (i modsætning til Hg0) er vandopløselig og kan således effektivt opfanges i en våd skrubber til SO2> kontrol. Derved er kombinationen af en SCR reaktor og et vådt afsvovlingsanlæg en mulig løsning for opfangning af kviksølv i røggasser. Laboratorieforsøg er blevet udført under dette Ph.D-studie for at kvantificere den Hg0 oxidation, som kan opnås over kommercielle SCR-katalysatorer ved forskellige gassammensætninger, operationsbetingelser og katalysatortyper. Herved er de følgende tre reaktioner blevet identificeret som relevante for kviksølvkemien over SCR-katalysatorer: R1. 2 HCl + Hg0 + 1/2 O2> ↔ HgCl2> + H2>O R2. 2 NH3> + 3 HgCl2> ↔ N2> + 3 Hg0 + 6 HCl R3. 2 NO + 2 NH3> + 1/2 O2> ↔ 2 N2> + 3 H2>O Reaktion R1 er oxidationen af Hg0 med klor, reaktion R2 er reduktionen af HgCl2> med NH3> og reaktion R3 er reduktionen af NO med NH3> (DeNOx reaktionen). Vigtigheden af de enkelte reaktioner for den samlede Hg0 oxidation afhænger af SCR operationstemperaturen. For T>325oC vil reduktionen af HgCl2> finde sted så længe NH3> er til stede. Den samlede Hg0 oxidation vil derfor afspejle den relative hastighed af Hg0 oxidationen via reaktion R1 og HgCl2> reduktionen via reaktion R2. For T=250-375oC vil DeNOx reaktionen sænke hastigheden af reaktion R1 ved at forbruge aktive vanadinoxid-sites på overfladen af katalysatoren. Disse sites skal reoxideres for at generhv
The vanadium-based SCR catalyst used for NOx-control promotes the oxidation of elemental mercury Hg0 to Hg2+ in flue gases from coal-fired power plants. Hg2+ is water soluble and can effectively be captured in a wet scrubber. This means that the combination of an SCR with a wet FGD can offer an effective control option for mercury. Laboratory experiments have been carried out to quantify the Hg0 oxidation that can be achieved over commercial SCR catalysts for different gas compositions, operating conditions and catalyst types. The following three net reactions have been identified as relevant for the mercury chemistry over the SCR: R1. 2 HCl + Hg0 + 1/2 O2> ↔ HgCl2> + H2>O R2. 2 NH3> + 3 HgCl2> ↔ N2> + 3 Hg0> + 6 HCl R3. 2 NO + 2 NH3> + 1/2 O2> ↔ 2 N2> + 3 H2>O where reaction R1 is the oxidation of Hg0> by HCl, reaction R2 is the reduction of HgCl2> by NH3> and reaction R3 is the DeNOx reaction. The importance of each reaction on the achievable Hg0 oxidation depends on the SCR operating temperature. At T>325oC, the reduction of HgCl2> will take place when NH3> is present. The overall Hg0 oxidation will then reflect the relative rate of the Hg0 oxidation via reaction R1 and the HgCl2> reduction via reaction R2. For T=250-375oC, the DeNOx reaction will inhibit the kinetics of reaction R1 by consuming active Lewis sites that must be oxidized to regain activity for Hg0 oxidation. The experimental data obtained in this study indicate that vanadia Lewis sites on SCR catalysts are active in the catalytic Hg0 oxidation - possibly as Hg0 adsorption sites. A kinetic model for the steady-state Hg0 oxidation over monolithic
URL :
http://orbit.dtu.dk/en/publications/mercury-oxidation-over-selective-catalytic-reduction-scr-catalysts--phd-thesis-karin-madsen(825edc34-74a2-495d-8077-4fb35317fbed).html
http://orbit.dtu.dk/fedora/objects/orbit:117534/datastreams/file_3d8433c3-67df-4fc9-8a86-225a98d251ab/content
http://orbit.dtu.dk/fedora/objects/orbit:117534/datastreams/file_3d8433c3-67df-4fc9-8a86-225a98d251ab/content
Zasób elektroniczny
Tytuł :
Ligand Binding and Thermostability of Different Allosteric States of the Instulin Zinc-Hexamer
Index Terms :
+p-aminobenzoate++chloride%2E+The+results+correlate+with+other+methods+and+demonstrate+that+DSC+provides+a+general+and+useful+method+of+evaluation+of+both+phenolic+and+anionic+ligand+binding+to+insulin+without+the+use+of+probes+or+other+alterations+of+the+system+of+interest%2E+However%2C+it+is+a+prerequisite+that+the+binding+is+strong+enough+to+saturate+the+binding+sites+at+temperatures+around+the+unfolding+transition%2E%22">The influence of ligand binding and conformation state on the thermostability of hexameric zinc-insulin was studied by differential scanning calorimetry (DSC). The insulin hexamer exists in equilibrium between the forms T6>, T3>R3>, and R6>. Phenolic ligands induce and stabilize the T3>R3>- and R6>-states which are further stabilized by binding of certain anions that do not stabilize the T6>-state. It was shown that the thermostability of the resorcinol-stabilized R6>-state was significantly higher than that of the T6>-state. Further analysis showed that phenol- and m-cresol-stabilized R6>-hexamer loses three ligands before reaching the unfolding temperature and hence unfolds from the T3>R3>-state. The relative affinity of the four tested anionic ligands was found, by DSC, to be thiocyanate = 4-hydroxy-3-nitrobenzoate p-aminobenzoate chloride. The results correlate with other methods and demonstrate that DSC provides a general and useful method of evaluation of both phenolic and anionic ligand binding to insulin without the use of probes or other alterations of the system of interest. However, it is a prerequisite that the binding is strong enough to saturate the binding sites at temperatures around the unfolding transition.
Udgivelsesdato: March 28
URL :
http://curis.ku.dk/portal/da/publications/ligand-binding-and-thermostability-of-different-allosteric-states-of-the-instulin-zinchexamer(52123bc0-6c37-11dc-bee9-02004c4f4f50).html
Zasób elektroniczny
Tytuł :
Dietary structured lipids for post-weaning piglets: fat digestibility, nitrogen retention and fatty acid profiles of tissues
Index Terms :
In four groups of post-weaning piglets the effects of triacylglycerol structure and fatty acid profiles of four dietary fats on apparent faecal nutrient digestibility, nitrogen retention and fatty acid profiles of platelet and erythrocyte membranes, liver, adipose tissue and skeletal muscle were examined. Dietary fats included as 10% (w/w) of the diets were two structured fats of rapeseed oil interesterified with tridecanoin (R1) or coconut oil (R2), respectively, one mixture of rapeseed oil and coconut oil (R3) and rapeseed oil as control (R4). Faeces and urine from piglets weaned at 28 days of age were collected quantitatively during three periods each of 5 days, in which the piglets were kept in metabolism cages for measurement of apparent faecal nutrient and energy digestibility and nitrogen retention. Apparent faecal fat digestibilities were significantly improved in groups fed interesterified fats or the physical mixtures (R1, R2 and R3) compared with rapeseed oil (R4). Apparent faecal nitrogen digestibility and retention were similar in all four groups in the three periods, but increased with time. Apparent faecal fat digestibilities were significantly improved from the first to the third week in the groups R1 and R2. Fatty acid profiles in platelet and erythrocyte membranes and in tissues reflected the fatty acid profile of the dietary fat, except for medium-chain fatty acids, which were only found in low proportions, indicating that 10:0 was mainly used as an energy source.
URL :
http://orbit.dtu.dk/en/publications/dietary-structured-lipids-for-postweaning-piglets-fat-digestibility-nitrogen-retention-and-fatty-acid-profiles-of-tissues(aa6e6a28-86f6-478f-95ff-848d1a9f5c31).html
Zasób elektroniczny

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