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Wyszukujesz frazę ""rab5 GTP-Binding Proteins"" wg kryterium: Temat


Tytuł :
Long Noncoding RNA NRAV Promotes Respiratory Syncytial Virus Replication by Targeting the MicroRNA miR-509-3p/Rab5c Axis To Regulate Vesicle Transportation.
Autorzy :
Li J; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.; Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.; Department of Pathogen Biology, Hebei Medical University, Shijiazhuang, Hebei, China.
Li M; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.; Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.
Wang X; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.; Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.; The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Sun M; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.; Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.
Ma C; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.; Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.
Liang W; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.; Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.; Department of Pathogen Biology, Hebei Medical University, Shijiazhuang, Hebei, China.
Gao X; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.; Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.
Wei L; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China .; Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.
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Źródło :
Journal of virology [J Virol] 2020 May 04; Vol. 94 (10). Date of Electronic Publication: 2020 May 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MicroRNAs/*metabolism
RNA, Long Noncoding/*metabolism
Respiratory Syncytial Virus Infections/*virology
Respiratory Syncytial Virus, Human/*drug effects
Respiratory Syncytial Virus, Human/*metabolism
Virus Replication/*drug effects
rab5 GTP-Binding Proteins/*metabolism
A549 Cells ; Adolescent ; Cell Line, Tumor ; Child ; Child, Preschool ; Down-Regulation ; Female ; Gene Expression ; Gene Knockdown Techniques ; Humans ; In Situ Hybridization, Fluorescence ; Male ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/pharmacology ; Respiratory Syncytial Virus, Human/genetics ; Respiratory Syncytial Virus, Human/pathogenicity ; rab5 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling.
Autorzy :
Heng J; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Lv P; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhang Y; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Cheng X; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Wang L; State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Ma D; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
Liu F; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
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Źródło :
PLoS biology [PLoS Biol] 2020 Apr 10; Vol. 18 (4), pp. e3000696. Date of Electronic Publication: 2020 Apr 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cells/*physiology
Proto-Oncogene Proteins c-akt/*metabolism
Receptors, Notch/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Animals ; Animals, Genetically Modified ; Embryo, Nonmammalian ; Endocytosis ; Endothelium/physiology ; Gene Expression Regulation, Developmental ; HEK293 Cells ; Humans ; Receptors, Notch/genetics ; T-Box Domain Proteins/genetics ; T-Box Domain Proteins/metabolism ; Transcription Factors/genetics ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish/metabolism ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism ; rab5 GTP-Binding Proteins/chemistry ; rab5 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Intracellular distribution and transcriptional regulation of Atlantic salmon (Salmo salar) Rab5c, 7a and 27a homologs by immune stimuli.
Autorzy :
Nepal A; Norwegian College of Fishery Science, Faculty of Biosciences, Fisheries & Economics, UiT The Arctic University of Norway, Tromsø, Norway.
Wolfson DL; Department of Physics and Technology, UiT The Arctic University of Norway, Tromsø, Norway.
Ahluwalia BS; Department of Physics and Technology, UiT The Arctic University of Norway, Tromsø, Norway.
Jensen I; Norwegian College of Fishery Science, Faculty of Biosciences, Fisheries & Economics, UiT The Arctic University of Norway, Tromsø, Norway.
Jørgensen J; Norwegian College of Fishery Science, Faculty of Biosciences, Fisheries & Economics, UiT The Arctic University of Norway, Tromsø, Norway.
Iliev DB; Norwegian College of Fishery Science, Faculty of Biosciences, Fisheries & Economics, UiT The Arctic University of Norway, Tromsø, Norway; Department of Gene Regulation, Institute of Molecular Biology 'Roumen Tsanev', Bulgarian Academy of Sciences, Sofia, Bulgaria. Electronic address: .
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Źródło :
Fish & shellfish immunology [Fish Shellfish Immunol] 2020 Apr; Vol. 99, pp. 119-129. Date of Electronic Publication: 2020 Jan 31.
Typ publikacji :
Journal Article
MeSH Terms :
Alphavirus Infections/*veterinary
Fish Proteins/*genetics
Salmo salar/*genetics
rab GTP-Binding Proteins/*genetics
rab27 GTP-Binding Proteins/*genetics
rab5 GTP-Binding Proteins/*genetics
Alphavirus ; Alphavirus Infections/immunology ; Animals ; Cells, Cultured ; Endosomes/genetics ; Fish Proteins/immunology ; Gene Expression ; Gene Expression Regulation ; Head Kidney/cytology ; Head Kidney/immunology ; Leukocytes/immunology ; Lysosomes/genetics ; Salmo salar/immunology ; Sequence Homology ; rab GTP-Binding Proteins/immunology ; rab27 GTP-Binding Proteins/immunology ; rab5 GTP-Binding Proteins/immunology
Czasopismo naukowe
Tytuł :
Stochastic activation and bistability in a Rab GTPase regulatory network.
Autorzy :
Bezeljak U; Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria.
Loya H; Department of Electrical Engineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra 400076, India.
Kaczmarek B; Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria.
Saunders TE; Mechanobiology Institute, National University of Singapore, Singapore 119077; .; Department of Biological Sciences, National University of Singapore, Singapore 119077.
Loose M; Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 24; Vol. 117 (12), pp. 6540-6549. Date of Electronic Publication: 2020 Mar 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Intracellular Membranes/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Feedback, Physiological ; GTP-Binding Protein Regulators/metabolism ; Guanosine Diphosphate/metabolism ; Intracellular Membranes/chemistry ; Models, Biological ; Protein Prenylation ; Protein Transport ; Signal Transduction ; Stochastic Processes ; Vesicular Transport Proteins/metabolism ; rab5 GTP-Binding Proteins/chemistry
Czasopismo naukowe
Tytuł :
EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation.
Autorzy :
Tang J; The Department of Anesthesiology, Affiliated hospital of Guangdong Medical University, Zhanjiang, 524000, China. .; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. .; Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. .; Key Laboratory of Organ Injury/Protection and Translational Medicine of Zhanjiang, Zhanjiang, 524000, China. .
Zhou B; Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Scott MJ; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Chen L; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China.
Lai D; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.; Department of Cardiovascular Surgery, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, 310052, China.
Fan EK; University of Pittsburgh The Graduate School of Public Health, Pittsburgh, PA, 15213, USA.
Li Y; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Wu Q; Laboratory of Tropical Biomedicine and Biotechnology, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, 571199, China.
Billiar TR; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Wilson MA; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.; Research and Development, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, 15240, USA.
Wang P; The Feinstein Institute for Medical Research, Manhasset, NY, 11030, USA.
Fan J; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. .; Research and Development, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, 15240, USA. .; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA. .
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Źródło :
Protein & cell [Protein Cell] 2020 Feb; Vol. 11 (2), pp. 144-149.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Macrophages/*metabolism
Toll-Like Receptor 4/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Dipeptides/pharmacology ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; HEK293 Cells ; Humans ; Hydroxamic Acids/pharmacology ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Phosphorylation/drug effects ; Quinazolines/pharmacology ; Signal Transduction/drug effects ; Surface Properties ; Toll-Like Receptor 4/genetics ; rab5 GTP-Binding Proteins/antagonists & inhibitors
Raport
Tytuł :
cGMP favors the interaction between APP and BACE1 by inhibiting Rab5 GTPase activity.
Autorzy :
Caudano F; Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Montalto G; Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Passalacqua M; Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Pronzato MA; Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Fedele E; Department of Pharmacy and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Ricciarelli R; Department of Experimental Medicine, University of Genoa, Genoa, Italy. .; IRCCS Ospedale Policlinico San Martino, Genoa, Italy. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jan 28; Vol. 10 (1), pp. 1358. Date of Electronic Publication: 2020 Jan 28.
Typ publikacji :
Journal Article
MeSH Terms :
Second Messenger Systems*
Alzheimer Disease/*metabolism
Amyloid Precursor Protein Secretases/*metabolism
Amyloid beta-Protein Precursor/*metabolism
Aspartic Acid Endopeptidases/*metabolism
Cell Membrane/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid Precursor Protein Secretases/genetics ; Amyloid beta-Protein Precursor/genetics ; Animals ; Aspartic Acid Endopeptidases/genetics ; Cell Line ; Cell Membrane/genetics ; Cell Membrane/pathology ; Cyclic GMP ; Endosomes/genetics ; Endosomes/metabolism ; Endosomes/pathology ; Mice ; rab5 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Roles of the G protein-coupled receptor kinase 2 and Rab5 in α 1B -adrenergic receptor function and internalization.
Autorzy :
Hernández-Espinosa DA; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ap. Postal 70-248, Ciudad Universitaria, Ciudad de México, 04510, Mexico.
Reyes-Cruz G; Departamento de Biología Celular, Centro de Investigación y Estudios Avanzados, CINVESTAV-IPN,Col, Pedro Zacatenco, Ciudad de México, 07360, Mexico.
García-Sáinz JA; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ap. Postal 70-248, Ciudad Universitaria, Ciudad de México, 04510, Mexico. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Jan 15; Vol. 867, pp. 172846. Date of Electronic Publication: 2019 Dec 04.
Typ publikacji :
Journal Article
MeSH Terms :
G-Protein-Coupled Receptor Kinase 2/*metabolism
Receptors, Adrenergic, alpha-1/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Adrenergic alpha-1 Receptor Agonists/pharmacology ; Fluorescence Resonance Energy Transfer ; G-Protein-Coupled Receptor Kinase 2/antagonists & inhibitors ; G-Protein-Coupled Receptor Kinase 2/genetics ; HEK293 Cells ; Humans ; Mutation ; Norepinephrine/pharmacology ; Paroxetine/pharmacology ; Phosphorylation/drug effects ; rab5 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif.
Autorzy :
Eggert S; Department of Human Biology and Human Genetics, Technical University of Kaiserslautern, Erwin-Schrödinger-Str. 13, 67663, Kaiserslautern, Germany.
Gruebl T; Department of Human Biology and Human Genetics, Technical University of Kaiserslautern, Erwin-Schrödinger-Str. 13, 67663, Kaiserslautern, Germany.
Rajender R; Department of Human Biology and Human Genetics, Technical University of Kaiserslautern, Erwin-Schrödinger-Str. 13, 67663, Kaiserslautern, Germany.
Rupp C; Department of Human Biology and Human Genetics, Technical University of Kaiserslautern, Erwin-Schrödinger-Str. 13, 67663, Kaiserslautern, Germany.
Sander B; Department of Human Biology and Human Genetics, Technical University of Kaiserslautern, Erwin-Schrödinger-Str. 13, 67663, Kaiserslautern, Germany.
Heesch A; Department of Human Biology and Human Genetics, Technical University of Kaiserslautern, Erwin-Schrödinger-Str. 13, 67663, Kaiserslautern, Germany.
Zimmermann M; Department of Human Biology and Human Genetics, Technical University of Kaiserslautern, Erwin-Schrödinger-Str. 13, 67663, Kaiserslautern, Germany.
Hoepfner S; MPI of Molecular Cell Biology and Genetics, Dresden, Germany.; Bird & Bird LLM, Munich, Germany.
Zentgraf H; DKFZ, Heidelberg, Germany.
Kins S; Department of Human Biology and Human Genetics, Technical University of Kaiserslautern, Erwin-Schrödinger-Str. 13, 67663, Kaiserslautern, Germany. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Dec; Vol. 77 (24), pp. 5223-5242. Date of Electronic Publication: 2020 Feb 17.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*genetics
Amino Acid Motifs/*genetics
Amyloid beta-Protein Precursor/*genetics
rab5 GTP-Binding Proteins/*genetics
Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Animals ; Carrier Proteins/genetics ; Endocytosis/genetics ; Endosomes/genetics ; Humans ; Mice ; Protein Transport/genetics ; Transport Vesicles/genetics
Czasopismo naukowe
Tytuł :
A comparative in silico analysis of Rab5 proteins from pathogenic species to find its role in the pathogenesis.
Autorzy :
Srivastava VK; Amity Institute of Biotechnology, Amity University Rajasthan, Kant Kalwar, Jaipur, India.
Kaushik S; Amity Institute of Biotechnology, Amity University Rajasthan, Kant Kalwar, Jaipur, India.
Jyoti A; Amity Institute of Biotechnology, Amity University Rajasthan, Kant Kalwar, Jaipur, India.
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Źródło :
Journal of molecular recognition : JMR [J Mol Recognit] 2019 Dec; Vol. 32 (12), pp. e2808. Date of Electronic Publication: 2019 Aug 20.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Computer Simulation*
Entamoeba histolytica/*metabolism
Leishmania donovani/*metabolism
Toxoplasma/*metabolism
rab5 GTP-Binding Proteins/*chemistry
Amino Acid Motifs ; Amino Acid Sequence ; Hydrogen Bonding ; Ligands ; Molecular Docking Simulation ; Structural Homology, Protein ; rab5 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Intracellular location of aquaporin-2 serine 269 phosphorylation and dephosphorylation in kidney collecting duct cells.
Autorzy :
Wong KY; Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Wang WL; Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Su SH; Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Liu CF; Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yu MJ; Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Oct 01; Vol. 319 (4), pp. F592-F602. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endocytosis*/drug effects
Aquaporin 2/*metabolism
Endosomes/*metabolism
Kidney Tubules, Collecting/*metabolism
Animals ; Cell Line ; Endosomes/drug effects ; Kidney Tubules, Collecting/cytology ; Kidney Tubules, Collecting/drug effects ; Mice ; Phosphorylation ; Protein Transport ; Serine ; Vasopressins/pharmacology ; Vesicular Transport Proteins/genetics ; Vesicular Transport Proteins/metabolism ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Structure and Dynamics of Mono- vs. Doubly Lipidated Rab5 in Membranes.
Autorzy :
Münzberg E; Max Planck Institute for Dynamics of Complex Technical Systems, Molecular Simulations and Design Group, Sandtorstrasse 1, 39106 Magdeburg, Germany. .
Stein M; Max Planck Institute for Dynamics of Complex Technical Systems, Molecular Simulations and Design Group, Sandtorstrasse 1, 39106 Magdeburg, Germany. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Sep 26; Vol. 20 (19). Date of Electronic Publication: 2019 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
Intracellular Membranes/*chemistry
Membrane Lipids/*chemistry
rab5 GTP-Binding Proteins/*chemistry
Amino Acid Sequence ; Diffusion ; Intracellular Membranes/metabolism ; Membrane Lipids/metabolism ; Models, Molecular ; Molecular Conformation ; Protein Binding ; Protein Interaction Domains and Motifs ; Structure-Activity Relationship ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Recognition and stabilization of geranylgeranylated human Rab5 by the GDP Dissociation Inhibitor (GDI).
Autorzy :
Edler E; a Molecular Simulations and Design Group, Max Planck Institute for Dynamics of Complex Technical Systems , Magdeburg , Germany.
Stein M; a Molecular Simulations and Design Group, Max Planck Institute for Dynamics of Complex Technical Systems , Magdeburg , Germany.
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Źródło :
Small GTPases [Small GTPases] 2019 May; Vol. 10 (3), pp. 227-242. Date of Electronic Publication: 2017 Oct 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Molecular Dynamics Simulation*
Multiprotein Complexes*
Protein Prenylation*
Diterpenes/*chemistry
Guanine Nucleotide Dissociation Inhibitors/*chemistry
rab5 GTP-Binding Proteins/*chemistry
Animals ; Cattle ; Diterpenes/metabolism ; Guanine Nucleotide Dissociation Inhibitors/genetics ; Guanine Nucleotide Dissociation Inhibitors/metabolism ; Humans ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Regulation of TORC2 function and localization by Rab5 GTPases in Saccharomyces cerevisiae .
Autorzy :
Locke MN; a Division of Biochemistry, Biophysics & Structural Biology, and Division of Cell & Developmental Biology, Department of Molecular and Cell Biology , University of California at Berkeley , Berkeley , CA , USA.
Thorner J; a Division of Biochemistry, Biophysics & Structural Biology, and Division of Cell & Developmental Biology, Department of Molecular and Cell Biology , University of California at Berkeley , Berkeley , CA , USA.
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Źródło :
Cell cycle (Georgetown, Tex.) [Cell Cycle] 2019 May; Vol. 18 (10), pp. 1084-1094. Date of Electronic Publication: 2019 May 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mechanistic Target of Rapamycin Complex 2/*metabolism
Saccharomyces cerevisiae/*metabolism
rab5 GTP-Binding Proteins/*physiology
Glycogen Synthase Kinase 3/metabolism ; Guanine Nucleotide Exchange Factors/metabolism ; Guanine Nucleotide Exchange Factors/physiology ; Humans ; Mechanistic Target of Rapamycin Complex 2/analysis ; Models, Molecular ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Saccharomyces cerevisiae Proteins/physiology ; Signal Transduction ; Up-Regulation ; rab5 GTP-Binding Proteins/analysis ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Efficient entry of budded virions of Autographa californica multiple nucleopolyhedrovirus into Spodoptera frugiperda cells is dependent on dynamin, Rab5, and Rab11.
Autorzy :
Yue Q; State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Li J; State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Guo Y; State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Yan F; State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Liu X; State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Blissard GW; Boyce Thompson Institute, Cornell University, Ithaca, 14853, New York, USA.
Li Z; State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address: .
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Źródło :
Insect biochemistry and molecular biology [Insect Biochem Mol Biol] 2020 Aug; Vol. 123, pp. 103409. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Nucleopolyhedroviruses*/growth & development
Nucleopolyhedroviruses*/metabolism
Dynamins/*genetics
Endosomes/*metabolism
rab GTP-Binding Proteins/*genetics
Animals ; Cell Line ; Endocytosis ; Host Microbial Interactions ; Lepidoptera/virology ; RNA Interference ; Sf9 Cells/virology ; Virus Internalization ; Virus Release ; Virus Replication ; rab5 GTP-Binding Proteins/genetics
SCR Organism :
Autographa californica multiple nuclear polyhedrosis virus
Czasopismo naukowe
Tytuł :
Modulation of ABCG2 surface expression by Rab5 and Rab21 to overcome multidrug resistance in cancer cells.
Autorzy :
Yousaf M; Institute of Biochemistry and Biotechnology, Quaid e Azam Campus, University of the Punjab, Lahore, Pakistan.
Ali M; Institute of Biochemistry and Biotechnology, Quaid e Azam Campus, University of the Punjab, Lahore, Pakistan.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Aug; Vol. 50 (8), pp. 988-996. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Drug Resistance, Multiple/*physiology
rab GTP-Binding Proteins/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Cell Line, Tumor ; Humans ; MCF-7 Cells
Czasopismo naukowe
Tytuł :
SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis.
Autorzy :
Kim H; Cell Logistics and Silver Health Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Oh H; Cell Logistics and Silver Health Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Oh YS; Cell Logistics and Silver Health Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Bae J; Center for Vascular Research, Institute for Basic Science, Daejeon, 34141, Republic of Korea.
Hong NH; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Park SJ; Cell Logistics and Silver Health Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Ahn S; Cell Logistics and Silver Health Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Lee M; Cell Logistics and Silver Health Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Rhee S; Department of Life Science, Chung-Ang University, Seoul, 06974, Republic of Korea.
Lee SH; Department of Cellular and Molecular Medicine, Chosun University School of Medicine, Gwangju, 61452, Republic of Korea.
Jun Y; Cell Logistics and Silver Health Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Kim SH; Department of Physiology, School of Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
Huh YH; Cell Logistics and Silver Health Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea. .
Song WK; Cell Logistics and Silver Health Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea. .
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Źródło :
Experimental & molecular medicine [Exp Mol Med] 2019 Jul 29; Vol. 51 (7), pp. 85. Date of Electronic Publication: 2019 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Adaptor Proteins, Signal Transducing/*metabolism
Endocytosis/*physiology
Endosomes/*metabolism
Guanine Nucleotide Exchange Factors/*metabolism
Muscle Proteins/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Endocytosis/genetics ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Guanine Nucleotide Exchange Factors/genetics ; HEK293 Cells ; HeLa Cells ; Humans ; Muscle Proteins/genetics ; Phosphorylation ; Protein Binding ; rab5 GTP-Binding Proteins/genetics ; src Homology Domains
Czasopismo naukowe
Tytuł :
Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production.
Autorzy :
Inoue J; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan .
Ninomiya M; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Umetsu T; Department of Internal Medicine, Kesen-numa City Hospital, Kesennuma, Japan.
Nakamura T; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kogure T; Division of Gastroenterology, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan.
Kakazu E; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Iwata T; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takai S; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Sano A; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Fukuda M; Department of Integrative Life Sciences, Tohoku University Graduate School of Life Sciences, Sendai, Japan.
Watashi K; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Isogawa M; Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Tanaka Y; Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Shimosegawa T; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Gastroenterology, South Miyagi Medical Center, Ogawara, Japan.
McNiven MA; Department of Biochemistry and Molecular Biology, and Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Masamune A; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
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Źródło :
Journal of virology [J Virol] 2019 Jul 17; Vol. 93 (15). Date of Electronic Publication: 2019 Jul 17 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Host Microbial Interactions*
Hepatitis B Surface Antigens/*metabolism
Hepatitis B virus/*growth & development
Hepatocytes/*virology
rab5 GTP-Binding Proteins/*metabolism
Cell Line ; Culture Media/chemistry ; DNA, Viral/analysis ; Endoplasmic Reticulum/metabolism ; Gene Silencing ; Genetic Testing ; Humans ; Multivesicular Bodies/metabolism ; Protein Transport ; RNA, Small Interfering ; rab5 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Rab5-dependent autophagosome closure by ESCRT.
Autorzy :
Zhou F; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.
Wu Z; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.
Zhao M; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.
Murtazina R; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL.
Cai J; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.
Zhang A; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.
Li R; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.
Sun D; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.
Li W; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.
Zhao L; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.
Li Q; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.
Zhu J; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Technology, Shanghai Jiao Tong University, Shanghai, China.
Cong X; Department of Biochemistry and Molecular Biology, Dr. Li Dak Sam and Yap Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Zhou Y; Department of Biochemistry and Molecular Biology, Dr. Li Dak Sam and Yap Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Xie Z; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Technology, Shanghai Jiao Tong University, Shanghai, China.
Gyurkovska V; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL.
Li L; State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
Huang X; State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
Xue Y; The National Laboratory of Biomacromolecules, Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Chen L; State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China.
Xu H; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.
Xu H; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.
Liang Y; College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China .
Segev N; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL .
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Źródło :
The Journal of cell biology [J Cell Biol] 2019 Jun 03; Vol. 218 (6), pp. 1908-1927. Date of Electronic Publication: 2019 Apr 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Autophagosomes/*physiology
Endosomal Sorting Complexes Required for Transport/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Endosomal Sorting Complexes Required for Transport/genetics ; Intracellular Membranes ; Lysosomes/metabolism ; Protein Transport ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae Proteins/genetics ; rab5 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Co-opted Cellular Sac1 Lipid Phosphatase and PI(4)P Phosphoinositide Are Key Host Factors during the Biogenesis of the Tombusvirus Replication Compartment.
Autorzy :
Sasvari Z; Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, USA.
Lin W; Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, USA.
Inaba JI; Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, USA.
Xu K; Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, USA.
Kovalev N; Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, USA.
Nagy PD; Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, USA .
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Źródło :
Journal of virology [J Virol] 2020 Jun 01; Vol. 94 (12). Date of Electronic Publication: 2020 Jun 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Host-Pathogen Interactions/*genetics
Phosphatidylinositol Phosphates/*metabolism
Phosphoric Monoester Hydrolases/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Tombusvirus/*genetics
Virus Replication/*genetics
1-Phosphatidylinositol 4-Kinase/genetics ; 1-Phosphatidylinositol 4-Kinase/metabolism ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis/virology ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Endosomes/metabolism ; Gene Expression Regulation ; Phosphatidylethanolamines/genetics ; Phosphatidylethanolamines/metabolism ; Phosphoric Monoester Hydrolases/deficiency ; Phosphoric Monoester Hydrolases/metabolism ; Plant Cells/metabolism ; Plant Cells/virology ; Plant Leaves/genetics ; Plant Leaves/metabolism ; Plant Leaves/virology ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protoplasts/metabolism ; Qa-SNARE Proteins/genetics ; Qa-SNARE Proteins/metabolism ; RNA-Dependent RNA Polymerase/genetics ; RNA-Dependent RNA Polymerase/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae/virology ; Saccharomyces cerevisiae Proteins/metabolism ; Signal Transduction ; Sterols/metabolism ; Tobacco/genetics ; Tobacco/metabolism ; Tobacco/virology ; Tombusvirus/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Alpha-synuclein differentially reduces surface expression of N-methyl-d-aspartate receptors in the aging human brain.
Autorzy :
Yang W; Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China; Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China.
Yu W; Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China; Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China.
Li X; Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China; Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China.
Li X; Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China; Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China.
Yu S; Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China; Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory for Parkinson's Disease, Beijing, China. Electronic address: .
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Źródło :
Neurobiology of aging [Neurobiol Aging] 2020 Jun; Vol. 90, pp. 24-32. Date of Electronic Publication: 2020 Feb 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*genetics
Aging/*metabolism
Gene Expression/*drug effects
Gene Expression/*genetics
Receptors, N-Methyl-D-Aspartate/*genetics
Receptors, N-Methyl-D-Aspartate/*metabolism
alpha-Synuclein/*metabolism
alpha-Synuclein/*pharmacology
Calcium/metabolism ; Cells, Cultured ; Corpus Striatum/metabolism ; Dose-Response Relationship, Drug ; Hippocampus/metabolism ; Humans ; alpha-Synuclein/physiology ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe

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