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Tytuł:
Fusion and fission events regulate endosome maturation and viral escape.
Autorzy:
Castro M; Grupo Interdisciplinar de Sistemas Complejos (GISC) and Instituto de Investigación Tecnológica (IIT), Universidad Pontificia Comillas, Madrid, Spain. .
Lythe G; Department of Applied Mathematics, School of Mathematics, University of Leeds, Leeds, UK.
Smit J; Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Groningen, The Netherlands.
Molina-París C; Department of Applied Mathematics, School of Mathematics, University of Leeds, Leeds, UK. .; Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Apr 12; Vol. 11 (1), pp. 7845. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Virus Internalization*
Endosomes/*metabolism
Viruses/*metabolism
rab GTP-Binding Proteins/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Biological Transport ; Endocytosis ; rab7 GTP-Binding Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Endosomal Wnt signaling proteins control microtubule nucleation in dendrites.
Autorzy:
Weiner AT; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Seebold DY; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Torres-Gutierrez P; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Folker C; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Swope RD; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Kothe GO; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Stoltz JG; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Zalenski MK; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Kozlowski C; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Barbera DJ; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Patel MA; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Thyagarajan P; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Shorey M; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Nye DMR; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Keegan M; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Behari K; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Song S; Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America.
Axelrod JD; Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America.
Rolls MM; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2020 Mar 12; Vol. 18 (3), pp. e3000647. Date of Electronic Publication: 2020 Mar 12 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Dendrites/*metabolism
Drosophila Proteins/*metabolism
Endosomes/*metabolism
Microtubules/*metabolism
Wnt Proteins/*metabolism
Animals ; Axin Signaling Complex/genetics ; Axin Signaling Complex/metabolism ; Axons/metabolism ; Cell Polarity ; Dendrites/genetics ; Drosophila ; Drosophila Proteins/genetics ; Endosomes/genetics ; Microtubules/genetics ; Mutation ; Receptors, Wnt/genetics ; Receptors, Wnt/metabolism ; Tubulin/genetics ; Tubulin/metabolism ; Wnt Proteins/genetics ; Wnt Signaling Pathway/genetics ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome-autophagosome-lysosome pathway dysfunction and microglia-mediated neuroinflammation.
Autorzy:
Xie Y; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ba L; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang M; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Deng SY; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chen SM; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huang LF; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang M; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang W; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Neurological Diseases of Chinese Ministry of Education, The School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ding FF; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2020 Feb; Vol. 26 (2), pp. 215-227. Date of Electronic Publication: 2019 Sep 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*
Autophagosomes/*pathology
Encephalitis/*pathology
Endosomes/*pathology
Lysosomes/*pathology
Microglia/*pathology
Neurodegenerative Diseases/*pathology
Sleep Deprivation/*pathology
Animals ; Anxiety/psychology ; Chronic Disease ; Cognition ; Maze Learning ; Memory ; Mice ; Mice, Inbred C57BL ; Recognition, Psychology ; rab GTP-Binding Proteins/metabolism ; rab5 GTP-Binding Proteins/metabolism ; rab7 GTP-Binding Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rab5-mediated endosome formation is regulated at the trans -Golgi network.
Autorzy:
Nagano M; 1Department of Biological Science and Technology, Tokyo University of Science, 6-3-1 Niijyuku, Katsushika-ku, Tokyo, 125-8585 Japan.
Toshima JY; 2School of Health Science, Tokyo University of Technology, 5-23-22 Nishikamada, Ota-ku, Tokyo, 144-8535 Japan.
Siekhaus DE; 3Institute of Science and Technology Austria, Am Campus 1, A-3400 Klosterneuburg, Austria.
Toshima J; 1Department of Biological Science and Technology, Tokyo University of Science, 6-3-1 Niijyuku, Katsushika-ku, Tokyo, 125-8585 Japan.
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Źródło:
Communications biology [Commun Biol] 2019 Nov 15; Vol. 2, pp. 419. Date of Electronic Publication: 2019 Nov 15 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endosomes/*metabolism
rab5 GTP-Binding Proteins/*metabolism
trans-Golgi Network/*metabolism
Biological Transport ; Endocytosis ; Fluorescent Antibody Technique ; Fungal Proteins ; Models, Biological ; Mutation ; Yeasts/genetics ; Yeasts/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Correlative single-molecule localization microscopy and electron tomography reveals endosome nanoscale domains.
Autorzy:
Franke C; Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Repnik U; Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Segeletz S; Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Brouilly N; Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Instutut de Biologie du Developpement de Marseille-Luminy, Aix-Marseille Universite, Marseille, France.
Kalaidzidis Y; Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia.
Verbavatz JM; Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Institut Jacques Monod, CNRS, Université Paris-Diderot, Paris, France.
Zerial M; Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
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Źródło:
Traffic (Copenhagen, Denmark) [Traffic] 2019 Aug; Vol. 20 (8), pp. 601-617.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Electron Microscope Tomography/*methods
Endosomes/*ultrastructure
Single Molecule Imaging/*methods
Endosomes/metabolism ; HeLa Cells ; Humans ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome.
Autorzy:
Goto-Silva L; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany.; D'Or Institute for Research and Education (IDOR), Rua Diniz Cordeiro, 30, 22281-100, Rio de Janeiro, Brazil.
McShane MP; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany.
Salinas S; Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia.; UMR1058. INSERM/Université de Montpellier/Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Montpellier, France.
Kalaidzidis Y; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany.; Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia.
Schiavo G; Molecular NeuroPathobiology Laboratory, Sobell Department of Motor Neuroscience & Movement Disorders, UCL Institute of Neurology, University College London, London, WC1N 3BG, UK.
Zerial M; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2019 Feb 21; Vol. 9 (1), pp. 2433. Date of Electronic Publication: 2019 Feb 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptor Proteins, Signal Transducing/*metabolism
Endosomes/*metabolism
Neurons/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Animals ; Axonal Transport/physiology ; Cells, Cultured ; Embryo, Mammalian ; Endocytosis/physiology ; Hippocampus/cytology ; Hippocampus/metabolism ; Mice ; Neurons/cytology ; Protein Transport ; Pyramidal Cells/metabolism ; Signal Transduction/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Kinesin-2 Controls the Motility of RAB5 Endosomes and Their Association with the Spindle in Mitosis.
Autorzy:
Pupo E; Department of Oncology, University of Torino Medical School, 10060 Torino, Italy. .; Candiolo Cancer Institute, FPO⁻IRCCS, Candiolo, 10060 Torino, Italy. .
Avanzato D; Department of Oncology, University of Torino Medical School, 10060 Torino, Italy. .; Candiolo Cancer Institute, FPO⁻IRCCS, Candiolo, 10060 Torino, Italy. .
Scianna M; Department of Mathematical Sciences, Politecnico di Torino, 10129 Torino, Italy. .
Oldani A; IFOM, The FIRC Institute for Molecular Oncology Foundation, 20139 Milan, Italy. .
Serini G; Department of Oncology, University of Torino Medical School, 10060 Torino, Italy. .; Candiolo Cancer Institute, FPO⁻IRCCS, Candiolo, 10060 Torino, Italy. .
Lanzetti L; Department of Oncology, University of Torino Medical School, 10060 Torino, Italy. .; Candiolo Cancer Institute, FPO⁻IRCCS, Candiolo, 10060 Torino, Italy. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Aug 30; Vol. 19 (9). Date of Electronic Publication: 2018 Aug 30.
Typ publikacji:
Journal Article
MeSH Terms:
Endosomes/*physiology
Kinesins/*genetics
Kinesins/*metabolism
Spindle Apparatus/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Cell Line ; Humans ; Interphase ; Metaphase ; Microtubules/metabolism ; RNA Interference
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dysregulation of Rab5-mediated endocytic pathways in Alzheimer's disease.
Autorzy:
Xu W; Institute of Neurology and Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Neurosciences, University of California, San Diego, San Diego, California.
Fang F; Institute of Neurology and Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Neurosciences, University of California, San Diego, San Diego, California.
Ding J; Institute of Neurology and Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wu C; Department of Neurosciences, University of California, San Diego, San Diego, California.
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Źródło:
Traffic (Copenhagen, Denmark) [Traffic] 2018 Apr; Vol. 19 (4), pp. 253-262. Date of Electronic Publication: 2018 Feb 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Alzheimer Disease/*metabolism
Axonal Transport/*physiology
Endosomes/*metabolism
Guanine Nucleotide Exchange Factors/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Animals ; Genome-Wide Association Study ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Leishmania donovani resides in modified early endosomes by upregulating Rab5a expression via the downregulation of miR-494.
Autorzy:
Verma JK; National Institute of Immunology, New Delhi, India.
Rastogi R; National Institute of Immunology, New Delhi, India.
Mukhopadhyay A; National Institute of Immunology, New Delhi, India.
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Źródło:
PLoS pathogens [PLoS Pathog] 2017 Jun 26; Vol. 13 (6), pp. e1006459. Date of Electronic Publication: 2017 Jun 26 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Endosomes/*parasitology
Leishmania donovani/*physiology
Leukocytes, Mononuclear/*parasitology
Macrophages/*parasitology
MicroRNAs/*genetics
rab5 GTP-Binding Proteins/*metabolism
Animals ; Down-Regulation ; Endosomes/microbiology ; Humans ; Lysosomes/metabolism ; Phagosomes/microbiology ; Transcriptional Activation/genetics ; Up-Regulation ; Vacuoles/parasitology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Rab5 isoforms orchestrate a "division of labor" in the endocytic network; Rab5C modulates Rac-mediated cell motility.
Autorzy:
Chen PI; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Schauer K; Molecular Mechanisms of Intracellular Transport, Institut Curie, Paris, France.
Kong C; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Harding AR; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Goud B; Molecular Mechanisms of Intracellular Transport, Institut Curie, Paris, France.
Stahl PD; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Feb 28; Vol. 9 (2), pp. e90384. Date of Electronic Publication: 2014 Feb 28 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Endocytosis/*genetics
Endosomes/*metabolism
rab5 GTP-Binding Proteins/*metabolism
rac1 GTP-Binding Protein/*metabolism
Cell Adhesion ; Cell Movement ; Endosomes/ultrastructure ; Gene Expression Regulation ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HeLa Cells ; Humans ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; rab5 GTP-Binding Proteins/antagonists & inhibitors ; rab5 GTP-Binding Proteins/genetics ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
MxA Is a Novel Regulator of Endosome-Associated Transcriptional Signaling by Bone Morphogenetic Proteins 4 and 9 (BMP4 and BMP9).
Autorzy:
Yuan H; Department of. Cell Biology & Anatomy, New York Medical College, Valhalla, New York, United States of America.
Sehgal PB; Department of. Cell Biology & Anatomy, and Department of Medicine, New York Medical College, Valhalla, New York, United States of America.
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Źródło:
PloS one [PLoS One] 2016 Nov 22; Vol. 11 (11), pp. e0166382. Date of Electronic Publication: 2016 Nov 22 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*
Transcription, Genetic*
Bone Morphogenetic Protein 4/*metabolism
Endosomes/*metabolism
Endothelial Cells/*metabolism
Growth Differentiation Factors/*metabolism
Hypertension, Pulmonary/*metabolism
Myxovirus Resistance Proteins/*metabolism
Pulmonary Artery/*metabolism
Bone Morphogenetic Protein 4/genetics ; Clathrin/genetics ; Clathrin/metabolism ; Endocytosis/genetics ; Endothelial Cells/pathology ; Growth Differentiation Factor 2 ; Growth Differentiation Factors/genetics ; HEK293 Cells ; Humans ; Hypertension, Pulmonary/genetics ; Interferon-alpha/genetics ; Interferon-alpha/metabolism ; Myxovirus Resistance Proteins/genetics ; Pulmonary Artery/pathology ; Smad1 Protein/genetics ; Smad1 Protein/metabolism ; Smad5 Protein/genetics ; Smad5 Protein/metabolism ; Smad8 Protein/genetics ; Smad8 Protein/metabolism ; Vesicular Transport Proteins ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Single GDP-dissociation Inhibitor Protein regulates endocytic and secretory pathways in Leishmania.
Autorzy:
Shanmugam SK; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.
Kumar K; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.
Singh PK; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.
Rastogi R; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.
Mukhopadhyay A; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.
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Źródło:
Scientific reports [Sci Rep] 2016 Nov 14; Vol. 6, pp. 37058. Date of Electronic Publication: 2016 Nov 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endocytosis/*physiology
Endosomes/*metabolism
Guanine Nucleotide Dissociation Inhibitors/*metabolism
Leishmania donovani/*metabolism
Metalloendopeptidases/*metabolism
Protozoan Proteins/*metabolism
Endosomes/genetics ; Guanine Nucleotide Dissociation Inhibitors/genetics ; Leishmania donovani/genetics ; Metalloendopeptidases/genetics ; Microorganisms, Genetically-Modified/genetics ; Microorganisms, Genetically-Modified/metabolism ; Protozoan Proteins/genetics ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Enrichment of Phosphatidylethanolamine in Viral Replication Compartments via Co-opting the Endosomal Rab5 Small GTPase by a Positive-Strand RNA Virus.
Autorzy:
Xu K; Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America.
Nagy PD; Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2016 Oct 19; Vol. 14 (10), pp. e2000128. Date of Electronic Publication: 2016 Oct 19 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Virus Replication*
Endosomes/*enzymology
Phosphatidylethanolamines/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Cell Compartmentation ; Tombusvirus/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages.
Autorzy:
Ku B; Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Lee KH
Park WS
Yang CS
Ge J
Lee SG
Cha SS
Shao F
Heo WD
Jung JU
Oh BH
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Źródło:
PLoS pathogens [PLoS Pathog] 2012; Vol. 8 (12), pp. e1003082. Date of Electronic Publication: 2012 Dec 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Bacterial Proteins/*metabolism
Carrier Proteins/*metabolism
Endosomes/*metabolism
Legionella pneumophila/*metabolism
Legionellosis/*metabolism
Macrophages/*metabolism
Nuclear Proteins/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Animals ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Biological Transport/genetics ; Carrier Proteins/genetics ; DNA-Binding Proteins ; Endosomes/genetics ; Endosomes/microbiology ; Endosomes/pathology ; HeLa Cells ; Humans ; Legionella pneumophila/chemistry ; Legionella pneumophila/genetics ; Legionellosis/genetics ; Legionellosis/pathology ; Lysosomes/genetics ; Lysosomes/metabolism ; Lysosomes/microbiology ; Lysosomes/pathology ; Macrophages/microbiology ; Macrophages/pathology ; Mice ; Nuclear Proteins/genetics ; Protein Structure, Tertiary ; RNA-Binding Proteins ; Vesicular Transport Proteins/genetics ; Vesicular Transport Proteins/metabolism ; rab5 GTP-Binding Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes.
Autorzy:
Satoh D; Department of Biophysics, Graduate School of Science, Sakyo-ku, Kyoto 606-8507, Japan.
Sato D
Tsuyama T
Saito M
Ohkura H
Rolls MM
Ishikawa F
Uemura T
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Źródło:
Nature cell biology [Nat Cell Biol] 2008 Oct; Vol. 10 (10), pp. 1164-71. Date of Electronic Publication: 2008 Aug 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dendrites/*metabolism
Drosophila melanogaster/*metabolism
Dyneins/*metabolism
Endosomes/*metabolism
rab5 GTP-Binding Proteins/*metabolism
Animals ; Axons/metabolism ; Biological Transport ; Carrier Proteins/metabolism ; Clone Cells ; Drosophila Proteins/metabolism ; Drosophila melanogaster/cytology ; Drosophila melanogaster/genetics ; Genes, Insect ; Kinesins/metabolism ; Morphogenesis ; Mutation/genetics ; Phenotype ; rab5 GTP-Binding Proteins/deficiency
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.
Autorzy:
Jun MH; Department of Biotechnology and Biological Sciences, Hannam University, 1646 Yuseongdaero, Yu-seong-gu, Daejeon, 305-811, South Korea. .
Han JH; Department of Biotechnology and Biological Sciences, Hannam University, 1646 Yuseongdaero, Yu-seong-gu, Daejeon, 305-811, South Korea. .
Lee YK; Department of Biotechnology and Biological Sciences, Hannam University, 1646 Yuseongdaero, Yu-seong-gu, Daejeon, 305-811, South Korea. .
Jang DJ; Applied Biology, College of Ecological Environment, Kyungpook National University, 386, Gajang-dong, Sang-Ju, South Korea. .
Kaang BK; Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea. .
Lee JA; Department of Biotechnology and Biological Sciences, Hannam University, 1646 Yuseongdaero, Yu-seong-gu, Daejeon, 305-811, South Korea. .
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Źródło:
Molecular brain [Mol Brain] 2015 Dec 10; Vol. 8, pp. 85. Date of Electronic Publication: 2015 Dec 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Polymorphism, Single Nucleotide*
Endosomal Sorting Complexes Required for Transport/*metabolism
Endosomes/*physiology
Frontotemporal Dementia/*metabolism
Membrane Proteins/*physiology
Nerve Tissue Proteins/*physiology
Neurons/*metabolism
Protein Transport/*physiology
Animals ; Autophagy ; Cells, Cultured ; Cerebral Cortex/cytology ; Cerebral Cortex/embryology ; Endosomal Sorting Complexes Required for Transport/genetics ; Endosomal Sorting Complexes Required for Transport/physiology ; Endosomes/chemistry ; Exons/genetics ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/pathology ; HEK293 Cells ; Humans ; Immunoprecipitation ; Introns/genetics ; Lysosomes/metabolism ; Membrane Proteins/genetics ; Mice ; Nerve Degeneration ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurons/pathology ; Protein Interaction Maps ; Proteolysis ; Recombinant Fusion Proteins/metabolism ; rab GTP-Binding Proteins/analysis ; rab5 GTP-Binding Proteins/analysis ; rab7 GTP-Binding Proteins
SCR Disease Name:
Chromosome 3-Linked Frontotemporal Dementia
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Infectious bursal disease virus uptake involves macropinocytosis and trafficking to early endosomes in a Rab5-dependent manner.
Autorzy:
Gimenez MC; Facultad de Farmacia y Bioquímica, Universidad Juan Agustín Maza, Mendoza, Argentina.; Instituto de Histología y Embriología (IHEM), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo - CONICET, Mendoza, Argentina.
Rodríguez Aguirre JF; Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología - CSIC, Madrid, Spain.
Colombo MI; Facultad de Farmacia y Bioquímica, Universidad Juan Agustín Maza, Mendoza, Argentina.; Instituto de Histología y Embriología (IHEM), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo - CONICET, Mendoza, Argentina.
Delgui LR; Facultad de Farmacia y Bioquímica, Universidad Juan Agustín Maza, Mendoza, Argentina.; Instituto de Histología y Embriología (IHEM), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo - CONICET, Mendoza, Argentina.; Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, Mendoza, Argentina.
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Źródło:
Cellular microbiology [Cell Microbiol] 2015 Jul; Vol. 17 (7), pp. 988-1007. Date of Electronic Publication: 2015 Feb 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pinocytosis*
Virus Internalization*
Endosomes/*virology
Infectious bursal disease virus/*physiology
rab5 GTP-Binding Proteins/*metabolism
Animals ; Biological Transport ; Birds ; Blotting, Western ; Cell Line ; Microscopy, Fluorescence ; Time Factors ; Viral Structural Proteins/analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An early endosome regulator, Rab5b, is an LRRK2 kinase substrate.
Autorzy:
Yun HJ; Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea .
Kim H; Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea .
Ga I; Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea.
Oh H; Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea.
Ho DH; Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea.
Kim J; Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea.
Seo H; Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea.
Son I; Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea .
Seol W; Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea .
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Źródło:
Journal of biochemistry [J Biochem] 2015 Jun; Vol. 157 (6), pp. 485-95. Date of Electronic Publication: 2015 Jan 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endosomes/*metabolism
Protein Serine-Threonine Kinases/*metabolism
rab5 GTP-Binding Proteins/*metabolism
ErbB Receptors/metabolism ; GTP Phosphohydrolases/metabolism ; HEK293 Cells ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ; Molecular Mimicry ; Phosphorylation ; Substrate Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.
Autorzy:
McKnight NC; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Zhong Y; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Wold MS; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Gong S; Laboratory of Molecular Biology, Howard Hughes Medical Institute, Rockefeller University, New York, New York, United States of America.
Phillips GR; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Dou Z; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, United States of America.
Zhao Y; Department of Applied Biology and Chemical Technology, State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Heintz N; Laboratory of Molecular Biology, Howard Hughes Medical Institute, Rockefeller University, New York, New York, United States of America.
Zong WX; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, United States of America.
Yue Z; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2014 Oct 02; Vol. 10 (10), pp. e1004626. Date of Electronic Publication: 2014 Oct 02 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis Regulatory Proteins/*metabolism
Class III Phosphatidylinositol 3-Kinases/*metabolism
Endosomes/*metabolism
Neurons/*metabolism
Tumor Suppressor Proteins/*metabolism
Animals ; Apoptosis Regulatory Proteins/genetics ; Autophagy/genetics ; Beclin-1 ; Class III Phosphatidylinositol 3-Kinases/genetics ; Endocytosis/genetics ; ErbB Receptors/metabolism ; HeLa Cells/metabolism ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neurons/pathology ; Phosphatidylinositol Phosphates/metabolism ; Tumor Suppressor Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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