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Tytuł :
Mechanistic Differences of Activation of Rac1 .
Autorzy :
Senyuz S; Computational Science and Engineering, Koc University, Rumelifeneri Yolu, 34450 Sariyer, Istanbul, Turkey.
Jang H; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer Immunometabolism, National Cancer Institute, Frederick, Maryland 21702, United States.
Nussinov R; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer Immunometabolism, National Cancer Institute, Frederick, Maryland 21702, United States.; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Keskin O; Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, 34450 Sariyer, Istanbul, Turkey.
Gursoy A; Computer Engineering, Koc University, Rumelifeneri Yolu, 34450 Sariyer, Istanbul, Turkey.
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Źródło :
The journal of physical chemistry. B [J Phys Chem B] 2021 Apr 22; Vol. 125 (15), pp. 3790-3802. Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Melanoma*
rac1 GTP-Binding Protein*/genetics
rac1 GTP-Binding Protein*/metabolism
Guanosine Triphosphate ; Humans ; Molecular Conformation ; Mutation ; ras Proteins
Czasopismo naukowe
Tytuł :
RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways.
Autorzy :
Gudiño V; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Inflammatory Bowel Disease Unit, Department of Gastroenterology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) - CIBEREHD, Barcelona, Spain.
Pohl SÖ; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Billard CV; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Cammareri P; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Bolado A; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Aitken S; MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Stevenson D; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, G61 1BD, UK.
Hall AE; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Agostino M; School of Pharmacy and Biomedical Sciences, Curtin Health and Innovation Research Institute, Curtin University, Perth, WA, 6845, Australia.; Curtin Institute for Computation, Curtin University, Perth, WA, 6845, Australia.
Cassidy J; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, CB2 0RE, UK.
Nixon C; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, G61 1BD, UK.
von Kriegsheim A; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Freile P; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Popplewell L; School of Biological Sciences, Royal Holloway - University of London, Egham, Surrey, TW20 0EX, UK.
Dickson G; School of Biological Sciences, Royal Holloway - University of London, Egham, Surrey, TW20 0EX, UK.
Murphy L; Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Wheeler A; Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Dunlop M; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Din F; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Strathdee D; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, G61 1BD, UK.
Sansom OJ; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Bearsden, Glasgow, G61 1QH, UK.
Myant KB; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 20; Vol. 12 (1), pp. 2335. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms/*etiology
Colorectal Neoplasms/*metabolism
rac1 GTP-Binding Protein/*metabolism
Animals ; Antineoplastic Agents, Immunological/pharmacology ; Carcinogenesis ; Cell Line, Tumor ; Cetuximab/pharmacology ; Colorectal Neoplasms/genetics ; Drug Resistance, Neoplasm ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neuropeptides/deficiency ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Signal Transduction ; Up-Regulation ; Wnt Signaling Pathway ; rac1 GTP-Binding Protein/deficiency ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
miR‑375 affects the hedgehog signaling pathway by downregulating RAC1 to inhibit hepatic stellate cell viability and epithelial‑mesenchymal transition.
Autorzy :
Liang Z; Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China.
Li J; Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China.
Zhao L; Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China.
Deng Y; Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Mar; Vol. 23 (3). Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition*
Signal Transduction*
Hedgehog Proteins/*metabolism
Hepatic Stellate Cells/*metabolism
Liver Cirrhosis/*metabolism
MicroRNAs/*metabolism
rac1 GTP-Binding Protein/*metabolism
Aged ; Animals ; Cell Survival ; Female ; Hedgehog Proteins/genetics ; Hepatic Stellate Cells/pathology ; Humans ; Liver Cirrhosis/genetics ; Liver Cirrhosis/pathology ; Male ; Mice ; MicroRNAs/genetics ; Middle Aged ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
ERK3 is transcriptionally upregulated by ∆Np63α and mediates the role of ∆Np63α in suppressing cell migration in non-melanoma skin cancers.
Autorzy :
Alshammari ES; Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, 112 Diggs Laboratory, 3640 Colonel Glenn Highway, Dayton, OH, 45435, USA.; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakakah, 72388, Saudi Arabia.
Aljagthmi AA; Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, 112 Diggs Laboratory, 3640 Colonel Glenn Highway, Dayton, OH, 45435, USA.
Stacy AJ; Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, 112 Diggs Laboratory, 3640 Colonel Glenn Highway, Dayton, OH, 45435, USA.
Bottomley M; Department of Math and Microbiology, College of Science and Mathematics, Wright State University, Dayton, OH, 45435, USA.
Shamma HN; Department of Dermatology, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH, 45435, USA.
Kadakia MP; Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, 112 Diggs Laboratory, 3640 Colonel Glenn Highway, Dayton, OH, 45435, USA. .
Long W; Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, 112 Diggs Laboratory, 3640 Colonel Glenn Highway, Dayton, OH, 45435, USA. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Feb 12; Vol. 21 (1), pp. 155. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*
Gene Expression Regulation, Neoplastic*
Transcriptional Activation*
Mitogen-Activated Protein Kinase 6/*metabolism
Skin Neoplasms/*pathology
Transcription Factors/*metabolism
Tumor Suppressor Proteins/*metabolism
rac1 GTP-Binding Protein/*metabolism
Cell Line ; Cell Line, Tumor ; Humans ; Mitogen-Activated Protein Kinase 6/genetics ; Phosphorylation ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Transcription Factors/genetics ; Tumor Suppressor Proteins/genetics ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
RAC1 nitration at Y IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury.
Autorzy :
Wang T; Department of Internal Medicine, College of Medicine Phoenix, University of Arizona, Phoenix, AZ, USA.
Yegambaram M; Division of Translational and Regenerative Medicine, Department of Medicine, College of Medicine Tucson, University of Arizona, Tucson, AZ, USA.
Gross C; Department of Medicine at Broward Health Medical Center, Fort Lauderdale, Florida, USA; Vascular Biology Center, Augusta University, Augusta, GA, Georgia.
Sun X; Division of Translational and Regenerative Medicine, Department of Medicine, College of Medicine Tucson, University of Arizona, Tucson, AZ, USA.
Lu Q; Division of Translational and Regenerative Medicine, Department of Medicine, College of Medicine Tucson, University of Arizona, Tucson, AZ, USA.
Wang H; Division of Translational and Regenerative Medicine, Department of Medicine, College of Medicine Tucson, University of Arizona, Tucson, AZ, USA.
Wu X; Division of Translational and Regenerative Medicine, Department of Medicine, College of Medicine Tucson, University of Arizona, Tucson, AZ, USA.
Kangath A; Division of Translational and Regenerative Medicine, Department of Medicine, College of Medicine Tucson, University of Arizona, Tucson, AZ, USA.
Tang H; Division of Translational and Regenerative Medicine, Department of Medicine, College of Medicine Tucson, University of Arizona, Tucson, AZ, USA.
Aggarwal S; Vascular Biology Center, Augusta University, Augusta, GA, Georgia; Department of Anesthesiology and Perioperative Medicine and Division of Molecular and Translational Biomedicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Black SM; Division of Translational and Regenerative Medicine, Department of Medicine, College of Medicine Tucson, University of Arizona, Tucson, AZ, USA. Electronic address: .
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Źródło :
Redox biology [Redox Biol] 2021 Jan; Vol. 38, pp. 101794. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Acute Lung Injury*/chemically induced
Acute Lung Injury*/enzymology
Acute Lung Injury*/pathology
Acute Lung Injury*/virology
Blood-Air Barrier*/enzymology
Blood-Air Barrier*/pathology
Blood-Air Barrier*/virology
COVID-19*/chemically induced
COVID-19*/enzymology
COVID-19*/pathology
Endothelial Cells*/metabolism
Endothelial Cells*/pathology
Endothelial Cells*/virology
Lipopolysaccharides/*toxicity
Neuropeptides/*metabolism
SARS-CoV-2/*metabolism
rac1 GTP-Binding Protein/*metabolism
Animals ; Cell Line ; Humans ; Male ; Mice ; Neuropeptides/genetics ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
Rac1 silencing, NSC23766 and EHT1864 reduce growth and actin organization of bladder smooth muscle cells.
Autorzy :
Wang R; Department of Urology, University Hospital, LMU Munich, Munich, Germany.
Yu Q; Department of Urology, University Hospital, LMU Munich, Munich, Germany; Department of Urology, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wang X; Department of Urology, University Hospital, LMU Munich, Munich, Germany.
Li B; Department of Urology, University Hospital, LMU Munich, Munich, Germany.
Ciotkowska A; Department of Urology, University Hospital, LMU Munich, Munich, Germany.
Rutz B; Department of Urology, University Hospital, LMU Munich, Munich, Germany.
Wang Y; Department of Urology, University Hospital, LMU Munich, Munich, Germany.
Stief CG; Department of Urology, University Hospital, LMU Munich, Munich, Germany.
Hennenberg M; Department of Urology, University Hospital, LMU Munich, Munich, Germany. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 15; Vol. 261, pp. 118468. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Actins/*metabolism
Aminoquinolines/*pharmacology
Myocytes, Smooth Muscle/*drug effects
Pyrimidines/*pharmacology
Pyrones/*pharmacology
Quinolines/*pharmacology
rac1 GTP-Binding Protein/*antagonists & inhibitors
Cell Line ; Cell Proliferation/drug effects ; Gene Silencing ; HEK293 Cells ; Humans ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/metabolism ; Urinary Bladder/cytology ; Urinary Bladder/drug effects ; Urinary Bladder/metabolism ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and Insulin Secretion in Pancreatic β-Cells.
Autorzy :
Thamilselvan V; Biomedical Research Service, John D. Dingell VA Medical Center, Detroit, MI, USA.; Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.
Gamage S; Biomedical Research Service, John D. Dingell VA Medical Center, Detroit, MI, USA.; Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.
Harajli A; Biomedical Research Service, John D. Dingell VA Medical Center, Detroit, MI, USA.; Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.
Chundru SA; Biomedical Research Service, John D. Dingell VA Medical Center, Detroit, MI, USA.; Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.
Kowluru A; Biomedical Research Service, John D. Dingell VA Medical Center, Detroit, MI, USA, .; Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2020 Dec 12; Vol. 54 (6), pp. 1218-1230.
Typ publikacji :
Journal Article
MeSH Terms :
Glucose/*pharmacology
Guanine Nucleotide Exchange Factors/*metabolism
Insulin Secretion/*drug effects
Insulin-Secreting Cells/*metabolism
rac1 GTP-Binding Protein/*metabolism
Animals ; Cell Line ; Enzyme Activation/drug effects ; Enzyme Activation/genetics ; Glucose/metabolism ; Guanine Nucleotide Exchange Factors/genetics ; Insulin Secretion/genetics ; Male ; Rats ; Rats, Sprague-Dawley ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
Butyrate-containing structured lipids inhibit RAC1 and epithelial-to-mesenchymal transition markers: a chemopreventive mechanism against hepatocarcinogenesis.
Autorzy :
de Conti A; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, AR, USA.
Tryndyak V; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, AR, USA.
Heidor R; Laboratory of Diet, Nutrition and Cancer, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Jimenez L; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, AR, USA.
Moreno FS; Laboratory of Diet, Nutrition and Cancer, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Beland FA; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, AR, USA.
Rusyn I; Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Pogribny IP; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, AR, USA. Electronic address: .
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Źródło :
The Journal of nutritional biochemistry [J Nutr Biochem] 2020 Dec; Vol. 86, pp. 108496. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition*
Butyrates/*pharmacology
Carcinoma, Hepatocellular/*prevention & control
Liver Neoplasms/*prevention & control
rac1 GTP-Binding Protein/*antagonists & inhibitors
Animals ; Anticarcinogenic Agents/pharmacology ; Carcinoma, Hepatocellular/metabolism ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Chemoprevention ; DNA/chemistry ; Gene Expression Profiling ; Humans ; Immunoprecipitation ; Lipids/chemistry ; Liver Neoplasms/metabolism ; Male ; Rats ; Rats, Wistar ; Signal Transduction/drug effects ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
"Janus" efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms.
Autorzy :
D'Amore C; Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, Padova, Italy. Electronic address: .
Moro E; Department of Molecular Medicine, University of Padova, Via U. Bassi 58/B, Padova, Italy.
Borgo C; Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, Padova, Italy.
Itami K; Institute of Transformative Bio-Molecules, Nagoya University, Nagoya 464-8601, Japan; Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya 464-8601, Japan.
Hirota T; Institute of Transformative Bio-Molecules, Nagoya University, Nagoya 464-8601, Japan.
Pinna LA; Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, Padova, Italy; CNR Institute of Neurosciences, Via U. Bassi 58/B, Padova, Italy.
Salvi M; Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, Padova, Italy. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2020 Nov; Vol. 1867 (11), pp. 118807. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Casein Kinase II/*genetics
Cell Death/*genetics
Neoplasms/*drug therapy
rac1 GTP-Binding Protein/*genetics
CRISPR-Cas Systems/genetics ; Casein Kinase II/antagonists & inhibitors ; Cell Death/drug effects ; Gene Editing ; Hep G2 Cells ; Humans ; Indoles/pharmacology ; Pinocytosis/drug effects ; Pinocytosis/genetics ; Pyrimidines/pharmacology ; Quinolines/pharmacology ; Vacuoles/drug effects ; Vacuoles/genetics ; rac1 GTP-Binding Protein/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Rho-GEF trio regulates osteoclast differentiation and function by Rac1/Cdc42.
Autorzy :
Gu J; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China; Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China.
Yang Z; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China; Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China.
Yuan L; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China; Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China.
Guo S; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China; Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China.
Wang D; Department of Stomatatology, Lianshui County People's Hospital, Kangda College of Nanjing Medical University, Huai'an, 223400, China.
Zhao N; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China; Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China.
Meng L; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China; Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China.
Liu H; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China; Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China.
Chen W; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China; Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China.
Ma J; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China; Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Nov 01; Vol. 396 (1), pp. 112265. Date of Electronic Publication: 2020 Sep 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Resorption/*genetics
Femur/*metabolism
Guanine Nucleotide Exchange Factors/*genetics
Neuropeptides/*genetics
Osteoclasts/*metabolism
Phosphoproteins/*genetics
Protein-Serine-Threonine Kinases/*genetics
cdc42 GTP-Binding Protein/*genetics
rac1 GTP-Binding Protein/*genetics
Animals ; Bone Resorption/metabolism ; Bone Resorption/pathology ; Cell Differentiation/drug effects ; Female ; Femur/cytology ; Femur/drug effects ; Gene Expression Regulation ; Guanine Nucleotide Exchange Factors/deficiency ; Macrophage Colony-Stimulating Factor/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Monocytes/cytology ; Monocytes/drug effects ; Monocytes/metabolism ; Neuropeptides/metabolism ; Osteoclasts/cytology ; Osteoclasts/drug effects ; Osteogenesis/drug effects ; Osteogenesis/genetics ; Phosphoproteins/deficiency ; Protein-Serine-Threonine Kinases/deficiency ; RANK Ligand/pharmacology ; Signal Transduction ; cdc42 GTP-Binding Protein/metabolism ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
High Expression of UBB , RAC1 , and ITGB1 Predicts Worse Prognosis among Nonsmoking Patients with Lung Adenocarcinoma through Bioinformatics Analysis.
Autorzy :
Deng H; Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou 310022, China.; Institute of Cancer Research and Basic Medical (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China.; Zhejiang Key Laboratory of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Huang Y; Department of Oncology, Maoming People's Hospital, Maoming 525000, China.
Wang L; Jiangxi Medical College, Nanchang University, Nanchang 330006, China.
Chen M; Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou 310022, China.; Institute of Cancer Research and Basic Medical (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China.; Zhejiang Key Laboratory of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
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Źródło :
BioMed research international [Biomed Res Int] 2020 Oct 20; Vol. 2020, pp. 2071593. Date of Electronic Publication: 2020 Oct 20 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma of Lung/*genetics
Carcinogenesis/*genetics
Integrin beta1/*genetics
Lung Neoplasms/*genetics
Ubiquitin/*genetics
rac1 GTP-Binding Protein/*genetics
Adenocarcinoma of Lung/diagnosis ; Adenocarcinoma of Lung/mortality ; Adenocarcinoma of Lung/pathology ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Computational Biology ; Databases, Genetic ; Disease Progression ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Ontology ; Gene Regulatory Networks ; Humans ; Integrin beta1/metabolism ; Lung Neoplasms/diagnosis ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Male ; Microarray Analysis ; Non-Smokers ; Prognosis ; Survival Analysis ; Ubiquitin/metabolism ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Evaluation of active Rac1 levels in cancer cells: A case of misleading conclusions from immunofluorescence analysis.
Autorzy :
Baker MJ; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: .
Cooke M; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Medicine, Einstein Medical Center Philadelphia, Philadelphia, Pennsylvania, USA.
Kreider-Letterman G; Department of Biological Sciences, University of Toledo, Ohio, USA.
Garcia-Mata R; Department of Biological Sciences, University of Toledo, Ohio, USA.
Janmey PA; Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Kazanietz MG; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Oct 02; Vol. 295 (40), pp. 13698-13710. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Membrane/*metabolism
Guanosine Triphosphate/*metabolism
Neoplasm Proteins/*metabolism
Prostatic Neoplasms/*metabolism
rac1 GTP-Binding Protein/*metabolism
Cell Membrane/genetics ; Cell Membrane/pathology ; Humans ; Male ; Microscopy, Fluorescence ; Neoplasm Proteins/genetics ; PC-3 Cells ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
StRac1 plays an important role in potato resistance against Phytophthora infestans via regulating H 2 O 2 production.
Autorzy :
Zhang Z; College of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Huhhot, Inner Mongolia, 010019 China. Electronic address: .
Zhang X; College of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Huhhot, Inner Mongolia, 010019 China. Electronic address: .
Na R; Institute of Cereal and Oil Crops, Hebei Academy of Agricultural and Forestry Sciences, Shijiazhuang, 050035 China. Electronic address: .
Yang S; College of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Huhhot, Inner Mongolia, 010019 China. Electronic address: .
Tian Z; College of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Huhhot, Inner Mongolia, 010019 China. Electronic address: .
Zhao Y; Institutes of Genetics and Developmental Biology, Chinese Academy of Science, Beijing, 100101 China. Electronic address: .
Zhao J; College of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Huhhot, Inner Mongolia, 010019 China. Electronic address: .
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Źródło :
Journal of plant physiology [J Plant Physiol] 2020 Oct; Vol. 253, pp. 153249. Date of Electronic Publication: 2020 Aug 16.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Resistance/*genetics
Hydrogen Peroxide/*metabolism
Phytophthora infestans/*physiology
Plant Diseases/*immunology
Solanum tuberosum/*genetics
rac1 GTP-Binding Protein/*metabolism
Gene Silencing ; Genes, Reporter ; Plant Diseases/parasitology ; Plant Leaves/genetics ; Plant Leaves/immunology ; Plant Leaves/parasitology ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plants, Genetically Modified ; Solanum tuberosum/immunology ; Solanum tuberosum/parasitology ; Tobacco/genetics ; Tobacco/metabolism ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
RAS and RHO family GTPase mutations in cancer: twin sons of different mothers?
Autorzy :
Hodge RG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Schaefer A; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Howard SV; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Der CJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Źródło :
Critical reviews in biochemistry and molecular biology [Crit Rev Biochem Mol Biol] 2020 Aug; Vol. 55 (4), pp. 386-407. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review; Video-Audio Media
MeSH Terms :
Carcinogenesis*/genetics
Carcinogenesis*/metabolism
Carcinogenesis*/pathology
Gain of Function Mutation*
Loss of Function Mutation*
Proto-Oncogene Proteins p21(ras)*/genetics
Proto-Oncogene Proteins p21(ras)*/metabolism
rac1 GTP-Binding Protein*/genetics
rac1 GTP-Binding Protein*/metabolism
rhoA GTP-Binding Protein*/genetics
rhoA GTP-Binding Protein*/metabolism
Animals ; Cell Movement ; Cell Proliferation ; Humans
Czasopismo naukowe
Tytuł :
Epac1 Is Crucial for Maintenance of Endothelial Barrier Function through A Mechanism Partly Independent of Rac1.
Autorzy :
García-Ponce A; Chair of Vegetative Anatomy, Faculty of Medicine, Ludwig-Maximilians-University (LMU) Munich, Pettenkoferstraße 11, D-80336 Munich, Germany.
Schuster K; Chair of Vegetative Anatomy, Faculty of Medicine, Ludwig-Maximilians-University (LMU) Munich, Pettenkoferstraße 11, D-80336 Munich, Germany.
Døskeland SO; Department of Biomedicine, University of Bergen, 5009 Bergen, Norway.
Reed RK; Department of Biomedicine, University of Bergen, 5009 Bergen, Norway.; Centre for Cancer Biomarkers, University of Bergen, 5020 Bergen, Norway.
Curry FE; Department of Physiology and Membrane Biology, University of California Davis, Davis, CA 95616, USA.
Waschke J; Chair of Vegetative Anatomy, Faculty of Medicine, Ludwig-Maximilians-University (LMU) Munich, Pettenkoferstraße 11, D-80336 Munich, Germany.
Radeva MY; Chair of Vegetative Anatomy, Faculty of Medicine, Ludwig-Maximilians-University (LMU) Munich, Pettenkoferstraße 11, D-80336 Munich, Germany.
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Źródło :
Cells [Cells] 2020 Sep 25; Vol. 9 (10). Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelial Cells/*metabolism
Guanine Nucleotide Exchange Factors/*genetics
Myocardium/*metabolism
Neuropeptides/*genetics
rac1 GTP-Binding Protein/*genetics
rap1 GTP-Binding Proteins/*drug effects
Animals ; Antigens, CD/genetics ; Cadherins/genetics ; Cell Membrane Permeability/drug effects ; Cyclic AMP/genetics ; Endothelial Cells/pathology ; Gene Expression Regulation/drug effects ; Humans ; Mice ; Mice, Knockout ; Myocardium/pathology ; Neuropeptides/agonists ; Signal Transduction/genetics ; Transcriptional Activation/drug effects ; rac1 GTP-Binding Protein/agonists ; rhoA GTP-Binding Protein/agonists ; rhoA GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
Lack of RAC1 in macrophages protects against atherosclerosis.
Autorzy :
Bandaru S; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Ala C; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Ekstrand M; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Akula MK; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Pedrelli M; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
Liu X; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Bergström G; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Physiology, Västra Götalandregionen, Sahlgrenska University Hospital, Gothenburg, Sweden.
Håversen L; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Borén J; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Bergo MO; Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
Akyürek LM; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Pathology, Västra Götalandregionen, Sahlgrenska University Hospital, Gothenburg, Sweden.
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Źródło :
PloS one [PLoS One] 2020 Sep 17; Vol. 15 (9), pp. e0239284. Date of Electronic Publication: 2020 Sep 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis/*metabolism
Macrophages/*metabolism
Neuropeptides/*genetics
rac1 GTP-Binding Protein/*genetics
Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/genetics ; Antigens, Differentiation, Myelomonocytic/metabolism ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Cells, Cultured ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Lipid Metabolism ; Mice ; Mice, Inbred C57BL ; Neuropeptides/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Rac1 activation in human breast carcinoma as a prognostic factor associated with therapeutic resistance.
Autorzy :
Yamaguchi M; Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Sendai, Miyagi-ken, 980-8575, Japan.
Takagi K; Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Sendai, Miyagi-ken, 980-8575, Japan. .
Sato A; Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Sendai, Miyagi-ken, 980-8575, Japan.
Miki Y; Department of Disaster Obstetrics and Gynecology, International Research Institute of Disaster Science, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken, 980-8573, Japan.
Miyashita M; Breast and Endocrine Surgical Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken, 980-8574, Japan.
Sasano H; Anatomic Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Sendai, Miyagi-ken, 980-8575, Japan.; Department of Pathology, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken, 980-8574, Japan.
Suzuki T; Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Sendai, Miyagi-ken, 980-8575, Japan.
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Źródło :
Breast cancer (Tokyo, Japan) [Breast Cancer] 2020 Sep; Vol. 27 (5), pp. 919-928. Date of Electronic Publication: 2020 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Breast Neoplasms/*therapy
Carcinoma, Ductal, Breast/*therapy
Neoplasm Recurrence, Local/*epidemiology
rac1 GTP-Binding Protein/*metabolism
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast/pathology ; Breast/surgery ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/mortality ; Carcinoma, Ductal, Breast/pathology ; Chemotherapy, Adjuvant/methods ; Disease Progression ; Disease-Free Survival ; Drug Resistance, Neoplasm ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Ki-67 Antigen/analysis ; Mastectomy ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/prevention & control ; rac1 GTP-Binding Protein/analysis
Czasopismo naukowe
Tytuł :
Centchroman prevents metastatic colonization of breast cancer cells and disrupts angiogenesis via inhibition of RAC1/PAK1/β-catenin signaling axis.
Autorzy :
Khan S; Laboratory of Cancer Epigenetics, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.
Shukla S; Laboratory of Cancer Epigenetics, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.
Farhan M; Laboratory of Cancer Epigenetics, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.
Sinha S; Laboratory of Cancer Epigenetics, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.
Lakra AD; Laboratory of Cancer Epigenetics, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.
Penta D; Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, India.
Kannan A; Department of Protein Chemistry and Technology, CSIR-Central Food Technological Research Institute, Mysore, India.
Meeran SM; Laboratory of Cancer Epigenetics, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India; Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, India. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 01; Vol. 256, pp. 117976. Date of Electronic Publication: 2020 Jun 16.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*metabolism
Centchroman/*pharmacology
Estrogen Antagonists/*pharmacology
Neuropeptides/*antagonists & inhibitors
beta Catenin/*antagonists & inhibitors
p21-Activated Kinases/*antagonists & inhibitors
rac1 GTP-Binding Protein/*antagonists & inhibitors
Animals ; Breast Neoplasms/drug therapy ; Centchroman/therapeutic use ; Estrogen Antagonists/therapeutic use ; Female ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; MCF-7 Cells ; Mice ; Mice, Inbred BALB C ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/metabolism ; Neuropeptides/metabolism ; Random Allocation ; Signal Transduction/drug effects ; Signal Transduction/physiology ; beta Catenin/metabolism ; p21-Activated Kinases/metabolism ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
TNFAIP8 promotes AML chemoresistance by activating ERK signaling pathway through interaction with Rac1.
Autorzy :
Pang Y; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Zhao Y; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Wang Y; Department of Hematology, Taian central hospital, Taian, 271000, Shandong, China.
Wang X; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Wang R; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Liu N; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Li P; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Ji M; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Ye J; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Sun T; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Li J; Department of Physiology, School of Basic Medical Sciences, Shandong University, Jinan, 250012, Shandong, China.
Ma D; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Lu F; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China. .
Ji C; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China. .
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Źródło :
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2020 Aug 14; Vol. 39 (1), pp. 158. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Antineoplastic Agents/*pharmacology
Apoptosis Regulatory Proteins/*metabolism
Leukemia, Myeloid, Acute/*drug therapy
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
rac1 GTP-Binding Protein/*metabolism
Adolescent ; Adult ; Aged ; Animals ; Apoptosis ; Apoptosis Regulatory Proteins/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Case-Control Studies ; Cell Movement ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Prognosis ; Signal Transduction ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays ; Young Adult ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe

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