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Tytuł:
Lack of RAC1 in macrophages protects against atherosclerosis.
Autorzy:
Bandaru S; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Ala C; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Ekstrand M; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Akula MK; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Pedrelli M; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
Liu X; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Bergström G; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Physiology, Västra Götalandregionen, Sahlgrenska University Hospital, Gothenburg, Sweden.
Håversen L; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Borén J; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Bergo MO; Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
Akyürek LM; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Pathology, Västra Götalandregionen, Sahlgrenska University Hospital, Gothenburg, Sweden.
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Źródło:
PloS one [PLoS One] 2020 Sep 17; Vol. 15 (9), pp. e0239284. Date of Electronic Publication: 2020 Sep 17 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Atherosclerosis/*metabolism
Macrophages/*metabolism
Neuropeptides/*genetics
rac1 GTP-Binding Protein/*genetics
Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/genetics ; Antigens, Differentiation, Myelomonocytic/metabolism ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Cells, Cultured ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Lipid Metabolism ; Mice ; Mice, Inbred C57BL ; Neuropeptides/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Involvement of the protein kinase Akt2 in insulin-stimulated Rac1 activation leading to glucose uptake in mouse skeletal muscle.
Autorzy:
Takenaka N; Laboratory of Cell Biology, Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka, Japan.
Araki N; Laboratory of Cell Biology, Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka, Japan.
Satoh T; Laboratory of Cell Biology, Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka, Japan.
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Źródło:
PloS one [PLoS One] 2019 Feb 08; Vol. 14 (2), pp. e0212219. Date of Electronic Publication: 2019 Feb 08 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glucose/*metabolism
Insulin/*pharmacology
Muscle, Skeletal/*metabolism
Neuropeptides/*metabolism
Proto-Oncogene Proteins c-akt/*biosynthesis
Sarcolemma/*enzymology
rac1 GTP-Binding Protein/*metabolism
Animals ; Down-Regulation/drug effects ; Enzyme Activation/drug effects ; Gene Expression Regulation, Enzymologic/drug effects ; Glucose Transporter Type 4/genetics ; Glucose Transporter Type 4/metabolism ; Male ; Mice ; Mutation ; Neuropeptides/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; RNA Interference ; Sarcolemma/genetics ; rac1 GTP-Binding Protein/genetics ; ral GTP-Binding Proteins/genetics ; ral GTP-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rac1 is dispensable for oocyte maturation and female fertility in vivo.
Autorzy:
Hao JX; Department of Obstetrics and Gynecology, General Hospital of Chinese People's Liberation Army, Beijing, China.
Meng TG; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Fan LH; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Yao YQ; Department of Obstetrics and Gynecology, General Hospital of Chinese People's Liberation Army, Beijing, China.
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Źródło:
PloS one [PLoS One] 2017 May 18; Vol. 12 (5), pp. e0177202. Date of Electronic Publication: 2017 May 18 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Fertility/*genetics
Neuropeptides/*metabolism
Oocytes/*physiology
rac1 GTP-Binding Protein/*metabolism
Animals ; Female ; Gene Knockdown Techniques ; Meiosis ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Mice, Transgenic ; Neuropeptides/genetics ; rac GTP-Binding Proteins/genetics ; rac GTP-Binding Proteins/metabolism ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The chicken embryo as an efficient model to test the function of muscle fusion genes in amniotes.
Autorzy:
Sieiro D; Australian Regenerative Medicine Institute (ARMI), Monash University, Clayton, Victoria, Australia.; Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon1, Faculty of Medicine Laënnec, Lyon, France.
Véron N; Australian Regenerative Medicine Institute (ARMI), Monash University, Clayton, Victoria, Australia.
Marcelle C; Australian Regenerative Medicine Institute (ARMI), Monash University, Clayton, Victoria, Australia.; Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon1, Faculty of Medicine Laënnec, Lyon, France.
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Źródło:
PloS one [PLoS One] 2017 May 16; Vol. 12 (5), pp. e0177681. Date of Electronic Publication: 2017 May 16 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Muscle Development*
Myoblasts/*metabolism
cdc42 GTP-Binding Protein/*metabolism
rac1 GTP-Binding Protein/*metabolism
Animals ; Cell Nucleus/metabolism ; Chick Embryo ; Muscle Proteins/genetics ; Muscle Proteins/metabolism ; Myoblasts/cytology ; cdc42 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
RAC1b overexpression stimulates proliferation and NF-kB-mediated anti-apoptotic signaling in thyroid cancer cells.
Autorzy:
Faria M; Unidade de Investigação de Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Lisboa, Portugal.
Matos P; BioISI-Biosystems and Integrative Sciences Institute, Faculdade de Ciências da Universidade de Lisboa, Portugal.; Instituto Nacional de Saúde, Doutor. Ricardo Jorge, Lisboa, Portugal.
Pereira T; Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Lisboa, Portugal.
Cabrera R; Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Lisboa, Portugal.
Cardoso BA; Unidade de Investigação de Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Lisboa, Portugal.
Bugalho MJ; Serviço de Endocrinologia, Diabetes e Metabolismo, do CHLN-Hospital Santa Maria, Lisboa, Portugal.; ISAMB-Instituto de Saúde Ambiental, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.
Silva AL; Unidade de Investigação de Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Lisboa, Portugal.; Serviço de Endocrinologia, Diabetes e Metabolismo, do CHLN-Hospital Santa Maria, Lisboa, Portugal.; ISAMB-Instituto de Saúde Ambiental, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.
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Źródło:
PloS one [PLoS One] 2017 Feb 24; Vol. 12 (2), pp. e0172689. Date of Electronic Publication: 2017 Feb 24 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
NF-kappa B/*genetics
Thyroid Epithelial Cells/*metabolism
rac1 GTP-Binding Protein/*genetics
Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclin D1/genetics ; Cyclin D1/metabolism ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; NF-KappaB Inhibitor alpha/genetics ; NF-KappaB Inhibitor alpha/metabolism ; NF-kappa B/metabolism ; Signal Transduction ; Staurosporine/pharmacology ; Thyroid Epithelial Cells/drug effects ; Thyroid Epithelial Cells/pathology ; Transfection ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Aerobic exercise regulates Rho/cofilin pathways to rescue synaptic loss in aged rats.
Autorzy:
Li Y; Department of Exercise Physiology, Beijing Sport University, Beijing, China.
Zhao L; Department of Exercise Physiology, Beijing Sport University, Beijing, China.
Gu B; Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, China.
Cai J; Department of Exercise Physiology, Beijing Sport University, Beijing, China.
Lv Y; Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, China.
Yu L; Department of Exercise Physiology, Beijing Sport University, Beijing, China.
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Źródło:
PloS one [PLoS One] 2017 Feb 02; Vol. 12 (2), pp. e0171491. Date of Electronic Publication: 2017 Feb 02 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Aging/*physiology
Physical Conditioning, Animal/*physiology
Signal Transduction/*physiology
Synapses/*physiology
rac1 GTP-Binding Protein/*physiology
rhoA GTP-Binding Protein/*physiology
Actin Depolymerizing Factors/analysis ; Actin Depolymerizing Factors/physiology ; Animals ; Blotting, Western ; Cerebral Cortex/chemistry ; Cerebral Cortex/physiology ; Fluorescent Antibody Technique ; Hippocampus/chemistry ; Hippocampus/physiology ; Male ; Rats ; Rats, Wistar ; cdc42 GTP-Binding Protein/analysis ; cdc42 GTP-Binding Protein/physiology ; rac1 GTP-Binding Protein/analysis ; rhoA GTP-Binding Protein/analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The interplay of Rac1 activity, ubiquitination and GDI binding and its consequences for endothelial cell spreading.
Autorzy:
Majolée J; Department of Physiology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Podieh F; Department of Physiology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Hordijk PL; Department of Physiology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Kovačević I; Department of Physiology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Department of Gene Regulation, Institute of Physiological Chemistry, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.
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Źródło:
PloS one [PLoS One] 2021 Jul 12; Vol. 16 (7), pp. e0254386. Date of Electronic Publication: 2021 Jul 12 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Movement*
Ubiquitination*
Human Umbilical Vein Endothelial Cells/*cytology
Human Umbilical Vein Endothelial Cells/*metabolism
rac1 GTP-Binding Protein/*metabolism
rho-Specific Guanine Nucleotide Dissociation Inhibitors/*metabolism
Amino Acid Sequence ; Cell Shape ; HEK293 Cells ; Humans ; Lysine/metabolism ; Mutant Proteins/metabolism ; Mutation/genetics ; Phenotype ; Proteasome Endopeptidase Complex/metabolism ; Protein Binding ; Ubiquitin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Semaphorin 3E deficiency dysregulates dendritic cell functions: In vitro and in vivo evidence.
Autorzy:
Movassagh H; Department of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Shan L; Department of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Koussih L; Department of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.; Department des Sciences Experimentales, Universite de Saint-Boniface, Winnipeg, Manitoba, Canada.
Alamri A; Department of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Ariaee N; Department of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Kung SKP; Department of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Gounni AS; Department of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
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Źródło:
PloS one [PLoS One] 2021 Jun 29; Vol. 16 (6), pp. e0252868. Date of Electronic Publication: 2021 Jun 29 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Disease Models, Animal*
Allergens/*immunology
Bone Marrow Cells/*immunology
Dendritic Cells/*immunology
Pneumonia/*immunology
Semaphorins/*physiology
Actins/metabolism ; Animals ; Cell Movement ; Chemokine CCL21/metabolism ; Mice ; Mice, Knockout ; Neuropeptides/metabolism ; Pneumonia/metabolism ; Pneumonia/pathology ; Receptors, CCR7/metabolism ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation.
Autorzy:
Castro-Castro A; Centro de Investigación del Cáncer, Salamanca, Spain.; Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, Salamanca, Spain.
Muriel O; Vascular Pathophysiology Department, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
Del Pozo MA; Vascular Pathophysiology Department, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
Bustelo XR; Centro de Investigación del Cáncer, Salamanca, Spain.; Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, Salamanca, Spain.; Centro de Investigación Biomédica en Red-Oncología, Carlos III Health Institute, Spain.
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Źródło:
PloS one [PLoS One] 2016 Nov 11; Vol. 11 (11), pp. e0166715. Date of Electronic Publication: 2016 Nov 11 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Basigin/*genetics
Cell Membrane/*metabolism
Membrane Glycoproteins/*genetics
Microfilament Proteins/*genetics
Proteins/*genetics
rac1 GTP-Binding Protein/*genetics
Actins/genetics ; Actins/metabolism ; Adaptor Proteins, Signal Transducing ; Animals ; Basigin/metabolism ; COS Cells ; Caveolin 1/genetics ; Caveolin 1/metabolism ; Cell Fractionation ; Chlorocebus aethiops ; Gene Expression Regulation ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Membrane Glycoproteins/metabolism ; Microfilament Proteins/metabolism ; Protein Transport ; Proteins/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; rac1 GTP-Binding Protein/metabolism ; rho Guanine Nucleotide Dissociation Inhibitor alpha/genetics ; rho Guanine Nucleotide Dissociation Inhibitor alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity.
Autorzy:
Chen L; Department of Surgery and Center for Cardiovascular Biology, University of Washington, Seattle, WA, United States of America.
DeWispelaere A; Department of Surgery and Center for Cardiovascular Biology, University of Washington, Seattle, WA, United States of America.
Dastvan F; Department of Surgery and Center for Cardiovascular Biology, University of Washington, Seattle, WA, United States of America.
Osborne WR; Department of Pediatrics and Diabetes and Obesity Center of Excellence at the University of Washington, Seattle, WA, United States of America.
Blechner C; Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Germany.
Windhorst S; Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Germany.
Daum G; Department of Surgery and Center for Cardiovascular Biology, University of Washington, Seattle, WA, United States of America.
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Źródło:
PloS one [PLoS One] 2016 May 13; Vol. 11 (5), pp. e0155726. Date of Electronic Publication: 2016 May 13 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Movement*
Actins/*metabolism
Muscle, Smooth, Vascular/*cytology
Myocytes, Smooth Muscle/*cytology
Myocytes, Smooth Muscle/*metabolism
rac1 GTP-Binding Protein/*antagonists & inhibitors
Animals ; Cell Proliferation ; Enzyme Activation ; Focal Adhesions/metabolism ; Gene Knockdown Techniques ; Mice ; Mitogen-Activated Protein Kinases/metabolism ; Mutation/genetics ; Serum/metabolism ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cleavage of Hyaluronan and CD44 Adhesion Molecule Regulate Astrocyte Morphology via Rac1 Signalling.
Autorzy:
Konopka A; Laboratory of Molecular and Systemic Neuromorphology, The Nencki Institute of Experimental Biology, 02-093, Warsaw, ul. Pasteura 3, Poland.
Zeug A; Cellular Neurophysiology, Center of Physiology, Hannover Medical School, 30625, Hannover, Germany.
Skupien A; Laboratory of Molecular and Systemic Neuromorphology, The Nencki Institute of Experimental Biology, 02-093, Warsaw, ul. Pasteura 3, Poland.
Kaza B; Laboratory of Molecular Neurobiology, Neurobiology Center, The Nencki Institute of Experimental Biology, 02-093, Warsaw, ul. Pasteura 3, Poland.
Mueller F; Cellular Neurophysiology, Center of Physiology, Hannover Medical School, 30625, Hannover, Germany.
Chwedorowicz A; Laboratory of Molecular and Systemic Neuromorphology, The Nencki Institute of Experimental Biology, 02-093, Warsaw, ul. Pasteura 3, Poland.
Ponimaskin E; Cellular Neurophysiology, Center of Physiology, Hannover Medical School, 30625, Hannover, Germany.
Wilczynski GM; Laboratory of Molecular and Systemic Neuromorphology, The Nencki Institute of Experimental Biology, 02-093, Warsaw, ul. Pasteura 3, Poland.
Dzwonek J; Laboratory of Molecular and Systemic Neuromorphology, The Nencki Institute of Experimental Biology, 02-093, Warsaw, ul. Pasteura 3, Poland.
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Źródło:
PloS one [PLoS One] 2016 May 10; Vol. 11 (5), pp. e0155053. Date of Electronic Publication: 2016 May 10 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Astrocytes/*metabolism
Brain/*metabolism
Extracellular Matrix/*metabolism
Hyaluronan Receptors/*genetics
Hyaluronic Acid/*chemistry
Neuropeptides/*genetics
rac1 GTP-Binding Protein/*genetics
Animals ; Animals, Newborn ; Astrocytes/cytology ; Brain/cytology ; Cell Adhesion ; Cell Movement ; Cytoskeleton/chemistry ; Cytoskeleton/metabolism ; Extracellular Matrix/chemistry ; Fluorescence Resonance Energy Transfer ; Gene Expression Regulation ; Hyaluronan Receptors/metabolism ; Hyaluronic Acid/metabolism ; Hyaluronoglucosaminidase/chemistry ; Hydrolysis ; Neuropeptides/metabolism ; Primary Cell Culture ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Rats ; Rats, Wistar ; Signal Transduction ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle.
Autorzy:
Takenaka N; Laboratory of Cell Biology, Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka, Japan.
Nihata Y; Laboratory of Cell Biology, Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka, Japan.
Satoh T; Laboratory of Cell Biology, Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka, Japan.
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Źródło:
PloS one [PLoS One] 2016 May 10; Vol. 11 (5), pp. e0155292. Date of Electronic Publication: 2016 May 10 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glucose Transporter Type 4/*metabolism
Guanine Nucleotide Exchange Factors/*metabolism
Insulin/*metabolism
Muscle, Skeletal/*metabolism
Myoblasts/*metabolism
Neuropeptides/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
rac1 GTP-Binding Protein/*metabolism
Animals ; Cell Fractionation ; Cell Line ; Gene Expression Regulation ; Glucose Transporter Type 4/genetics ; Guanine Nucleotide Exchange Factors/antagonists & inhibitors ; Guanine Nucleotide Exchange Factors/genetics ; Insulin/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/cytology ; Myoblasts/cytology ; Neuropeptides/genetics ; Protein Transport ; Proto-Oncogene Proteins c-akt/genetics ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Tissue Culture Techniques ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Role of Rac1 in the Growth Cone Dynamics and Force Generation of DRG Neurons.
Autorzy:
Sayyad WA; Neuroscience Area, International School for Advanced Studies (SISSA), Trieste, Italy.
Fabris P; Neuroscience Area, International School for Advanced Studies (SISSA), Trieste, Italy.
Torre V; Neuroscience Area, International School for Advanced Studies (SISSA), Trieste, Italy.
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Źródło:
PloS one [PLoS One] 2016 Jan 14; Vol. 11 (1), pp. e0146842. Date of Electronic Publication: 2016 Jan 14 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ganglia, Spinal/*cytology
Ganglia, Spinal/*physiology
Growth Cones/*metabolism
Posterior Horn Cells/*physiology
rac1 GTP-Binding Protein/*genetics
rac1 GTP-Binding Protein/*metabolism
Actin-Related Protein 2-3 Complex/antagonists & inhibitors ; Animals ; Cell Movement/drug effects ; Enzyme Activation/drug effects ; Pseudopodia/drug effects ; Pseudopodia/physiology ; Rats ; Thiazoles/pharmacology ; rac1 GTP-Binding Protein/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.
Autorzy:
Oprea TI; Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.; Translational Informatics Division, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Sklar LA; Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.; Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.; University of New Mexico Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Agola JO; Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Guo Y; Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.; Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Silberberg M; Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Roxby J; Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Vestling A; Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Romero E; Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Surviladze Z; Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.; University of New Mexico Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Murray-Krezan C; Division of Epidemiology, Biostatistics, and Preventive Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Waller A; Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.; University of New Mexico Center for Molecular Discovery, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Ursu O; Translational Informatics Division, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Hudson LG; Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.; Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Wandinger-Ness A; Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.; Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
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Źródło:
PloS one [PLoS One] 2015 Nov 11; Vol. 10 (11), pp. e0142182. Date of Electronic Publication: 2015 Nov 11 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Ketorolac/*pharmacology
Naproxen/*pharmacology
cdc42 GTP-Binding Protein/*antagonists & inhibitors
rac1 GTP-Binding Protein/*antagonists & inhibitors
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; HeLa Cells ; Humans ; Immunoblotting ; Ketorolac/chemistry ; Ketorolac/metabolism ; Mice ; Microscopy, Confocal ; Molecular Docking Simulation ; Molecular Structure ; NIH 3T3 Cells ; Naproxen/chemistry ; Naproxen/metabolism ; Protein Binding ; Protein Structure, Tertiary ; Stereoisomerism ; cdc42 GTP-Binding Protein/chemistry ; cdc42 GTP-Binding Protein/metabolism ; rac1 GTP-Binding Protein/chemistry ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The GTPase ARF6 Controls ROS Production to Mediate Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation.
Autorzy:
Bourmoum M; Department of Pharmacology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Charles R; Department of Pharmacology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Claing A; Department of Pharmacology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
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Źródło:
PloS one [PLoS One] 2016 Jan 29; Vol. 11 (1), pp. e0148097. Date of Electronic Publication: 2016 Jan 29 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
ADP-Ribosylation Factors/*genetics
Angiotensin II/*pharmacology
Myocytes, Smooth Muscle/*drug effects
NADH, NADPH Oxidoreductases/*genetics
Vasoconstrictor Agents/*pharmacology
rac1 GTP-Binding Protein/*genetics
ADP-Ribosylation Factor 6 ; ADP-Ribosylation Factors/antagonists & inhibitors ; ADP-Ribosylation Factors/metabolism ; Animals ; Cell Line ; Cell Proliferation/drug effects ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Gene Expression Regulation ; MAP Kinase Kinase 4/genetics ; MAP Kinase Kinase 4/metabolism ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/metabolism ; NADH, NADPH Oxidoreductases/metabolism ; NADPH Oxidase 1 ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Rats ; Reactive Oxygen Species/metabolism ; Receptor, Angiotensin, Type 1/genetics ; Receptor, Angiotensin, Type 1/metabolism ; Signal Transduction ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genome-wide DNA methylation analysis of breast cancer MCF-7 / Taxol cells with MeDIP-Seq.
Autorzy:
Shi Y; Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Gong W; Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Gong X; Internal Medicine Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wang P; Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhao X; Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
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Źródło:
PloS one [PLoS One] 2020 Dec 11; Vol. 15 (12), pp. e0241515. Date of Electronic Publication: 2020 Dec 11 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Methylation*
Breast Neoplasms/*drug therapy
Breast Neoplasms/*genetics
Drug Resistance, Neoplasm/*genetics
Paclitaxel/*pharmacology
Antineoplastic Agents, Phytogenic/pharmacology ; Breast Neoplasms/metabolism ; Epigenesis, Genetic ; Female ; Gene Expression Profiling ; Gene Ontology ; Gene Regulatory Networks ; Humans ; Immunoprecipitation ; MCF-7 Cells ; Sequence Analysis, DNA/methods ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SPARC Controls Melanoma Cell Plasticity through Rac1.
Autorzy:
Salvatierra E; Laboratory of Molecular and Cellular Therapy, Instituto Leloir-CONICET, Buenos Aires, C1405, Argentina.
Alvarez MJ; Laboratory of Molecular and Cellular Therapy, Instituto Leloir-CONICET, Buenos Aires, C1405, Argentina.
Leishman CC; Laboratory of Molecular and Cellular Therapy, Instituto Leloir-CONICET, Buenos Aires, C1405, Argentina.
Rivas Baquero E; Laboratory of Molecular and Cellular Therapy, Instituto Leloir-CONICET, Buenos Aires, C1405, Argentina.
Lutzky VP; Laboratory of Immunomodulators, School of Medicine, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET)-University of Buenos Aires, Buenos Aires, Argentina.
Chuluyan HE; Laboratory of Immunomodulators, School of Medicine, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET)-University of Buenos Aires, Buenos Aires, Argentina.
Podhajcer OL; Laboratory of Molecular and Cellular Therapy, Instituto Leloir-CONICET, Buenos Aires, C1405, Argentina.
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Źródło:
PloS one [PLoS One] 2015 Aug 06; Vol. 10 (8), pp. e0134714. Date of Electronic Publication: 2015 Aug 06 (Print Publication: 2015).
Typ publikacji:
Journal Article
MeSH Terms:
Cell Plasticity*
Osteonectin/*metabolism
rac1 GTP-Binding Protein/*metabolism
Actin Cytoskeleton/metabolism ; Cell Adhesion ; Cell Line, Tumor ; Cell Movement ; Down-Regulation ; Humans ; Integrins/chemistry ; Integrins/metabolism ; Melanoma/metabolism ; Melanoma/pathology ; Osteonectin/chemistry ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; rac1 GTP-Binding Protein/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.
Autorzy:
Zhang SC; Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich-Heine University, Düsseldorf, Germany.
Gremer L; Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich-Heine University, Düsseldorf, Germany; Institute of Physical Biology, Heinrich-Heine University, Düsseldorf, Germany; Institute of Complex Systems, ICS-6, Research Center Jülich GmbH, Jülich, Germany.
Heise H; Institute of Physical Biology, Heinrich-Heine University, Düsseldorf, Germany; Institute of Complex Systems, ICS-6, Research Center Jülich GmbH, Jülich, Germany.
Janning P; Department of Chemical Biology, Max-Planck Institute of Molecular Physiology, Dortmund, Germany.
Shymanets A; Institute of Experimental and Clinical Pharmacology and Toxicology, Tübingen Medical School, Tübingen, Germany.
Cirstea IC; Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich-Heine University, Düsseldorf, Germany; Leibniz Institute for Age Research, Jena, Germany.
Krause E; Laboratory of Mass Spectrometry, Leibniz Institute of Molecular Pharmacology, Berlin, Germany.
Nürnberg B; Institute of Experimental and Clinical Pharmacology and Toxicology, Tübingen Medical School, Tübingen, Germany.
Ahmadian MR; Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich-Heine University, Düsseldorf, Germany.
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Źródło:
PloS one [PLoS One] 2014 Jul 11; Vol. 9 (7), pp. e102425. Date of Electronic Publication: 2014 Jul 11 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Processing, Post-Translational*
Guanine Nucleotide Dissociation Inhibitors/*chemistry
Guanine Nucleotide Exchange Factors/*chemistry
Liposomes/*chemistry
p21-Activated Kinases/*chemistry
rac1 GTP-Binding Protein/*chemistry
Animals ; Baculoviridae/genetics ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Guanine Nucleotide Dissociation Inhibitors/genetics ; Guanine Nucleotide Dissociation Inhibitors/metabolism ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism ; Humans ; Liposomes/metabolism ; Models, Biological ; Protein Prenylation ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Spodoptera ; p21-Activated Kinases/genetics ; p21-Activated Kinases/metabolism ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The role of endothelial MERTK during the inflammatory response in lungs.
Autorzy:
Li Y; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Wittchen ES; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Monaghan-Benson E; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Hahn C; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Earp HS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Doerschuk CM; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Burridge K; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
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Źródło:
PloS one [PLoS One] 2019 Dec 05; Vol. 14 (12), pp. e0225051. Date of Electronic Publication: 2019 Dec 05 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Endothelial Cells/*metabolism
Inflammation/*metabolism
Lung/*metabolism
c-Mer Tyrosine Kinase/*metabolism
Adherens Junctions/metabolism ; Animals ; Capillary Permeability/physiology ; Child ; Female ; Gene Knockdown Techniques ; Humans ; Mice ; Mice, Knockout ; c-Mer Tyrosine Kinase/genetics ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Integrative omics analysis of rheumatoid arthritis identifies non-obvious therapeutic targets.
Autorzy:
Whitaker JW; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America.
Boyle DL; Division of Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, California, United States of America.
Bartok B; Division of Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, California, United States of America.
Ball ST; Department of Orthopaedics, University of California San Diego School of Medicine, La Jolla, California, United States of America.
Gay S; Department of Rheumatology, University Hospital Zürich, CH-8091, Zurich, Switzerland.
Wang W; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America.
Firestein GS; Division of Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, California, United States of America.
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Źródło:
PloS one [PLoS One] 2015 Apr 22; Vol. 10 (4), pp. e0124254. Date of Electronic Publication: 2015 Apr 22 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptor Proteins, Signal Transducing/*genetics
Arthritis, Rheumatoid/*genetics
Fibroblasts/*metabolism
Synovial Membrane/*metabolism
rac1 GTP-Binding Protein/*genetics
Adaptor Proteins, Signal Transducing/antagonists & inhibitors ; Adaptor Proteins, Signal Transducing/metabolism ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/pathology ; Cell Movement ; Cell Proliferation ; DNA Methylation ; Fibroblasts/pathology ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; Genome-Wide Association Study ; Humans ; Proteomics/methods ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Synovial Membrane/pathology ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 162

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