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Wyszukujesz frazę ""rap1 GTP-Binding Proteins"" wg kryterium: Temat


Tytuł:
Spatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination.
Autorzy:
Sewduth RN; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, 3000, Belgium.; Department of Oncology, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
Carai P; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
Ivanisevic T; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, 3000, Belgium.; Department of Oncology, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
Zhang M; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer ImmunoMetabolism, National Cancer Institute, Frederick, MD, 21702, USA.
Jang H; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer ImmunoMetabolism, National Cancer Institute, Frederick, MD, 21702, USA.
Lechat B; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, 3000, Belgium.; Department of Oncology, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
Van Haver D; VIB-UGent Center for Medical Biotechnology, Technologiepark-Zwijnaarde 75, Ghent, 9052, Belgium.; Department of Biomolecular Medicine, Ghent University, Technologiepark-Zwijnaarde 75, Ghent, 9052, Belgium.; VIB Proteomics Core, Technologiepark-Zwijnaarde 75, Ghent, 9052, Belgium.
Impens F; VIB-UGent Center for Medical Biotechnology, Technologiepark-Zwijnaarde 75, Ghent, 9052, Belgium.; Department of Biomolecular Medicine, Ghent University, Technologiepark-Zwijnaarde 75, Ghent, 9052, Belgium.; VIB Proteomics Core, Technologiepark-Zwijnaarde 75, Ghent, 9052, Belgium.
Nussinov R; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer ImmunoMetabolism, National Cancer Institute, Frederick, MD, 21702, USA.; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.
Jones E; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.; Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, Universiteitssingel 50, Maastricht, 6229 ER, The Netherlands.
Sablina A; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, 3000, Belgium.; Department of Oncology, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
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Źródło:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Dec; Vol. 10 (36), pp. e2303367. Date of Electronic Publication: 2023 Nov 09.
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells*/metabolism
GTP Phosphohydrolases*/metabolism
Animals ; Mice ; Reactive Oxygen Species/metabolism ; Proteome/metabolism ; rap1 GTP-Binding Proteins/genetics ; rap1 GTP-Binding Proteins/metabolism ; Mice, Knockout ; Ubiquitination
Czasopismo naukowe
Tytuł:
Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure.
Autorzy:
Jalal MM; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.; Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Whyte CS; Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Coxon FP; Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Mutch NJ; Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
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Źródło:
Platelets [Platelets] 2023 Dec; Vol. 34 (1), pp. 2206921.
Typ publikacji:
Journal Article
MeSH Terms:
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/pharmacology
Thrombosis*/drug therapy
Thrombosis*/metabolism
Humans ; Adenosine Diphosphate/metabolism ; Atorvastatin/pharmacology ; Blood Platelets/metabolism ; Fibrinogen/metabolism ; Prenylation ; rab GTP-Binding Proteins/metabolism ; rap1 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling.
Autorzy:
Ishihara S; Department of Biosciences, School of Science, Kitasato University, 1-15-1 Kitasato, Minamiku, Sagamihara, Kanagawa, 252-0344, Japan.
Sato T; Department of Biosciences, School of Science, Kitasato University, 1-15-1 Kitasato, Minamiku, Sagamihara, Kanagawa, 252-0344, Japan.
Fujikado N; Immunology Discovery Research, Lilly Research Laboratories, Lilly Biotechnology Center, Eli Lilly and Company, 10290 Campus Point Drive, San Diego, CA, 92121, USA.
Miyazaki H; Department of Biosciences, School of Science, Kitasato University, 1-15-1 Kitasato, Minamiku, Sagamihara, Kanagawa, 252-0344, Japan.
Yoshimoto T; Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan.
Yamamoto H; Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan.
Fukuda S; Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan.; Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, 3-25-13 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan.; Transborder Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Katagiri K; Department of Biosciences, School of Science, Kitasato University, 1-15-1 Kitasato, Minamiku, Sagamihara, Kanagawa, 252-0344, Japan. .
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Źródło:
Communications biology [Commun Biol] 2022 Mar 04; Vol. 5 (1), pp. 206. Date of Electronic Publication: 2022 Mar 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colitis*/metabolism
Colitis*/prevention & control
Th17 Cells*/metabolism
rap1 GTP-Binding Proteins*/genetics
Animals ; Cell Differentiation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes, Regulatory/metabolism
Czasopismo naukowe
Tytuł:
Rap1A accelerates homocysteine-induced ANA-1 cells inflammation via synergy of FoxO1 and DNMT3a.
Autorzy:
Wu H; Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan 75004, China.
Li Z; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China; NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 750004, China.
Yang Y; Department of Pathology, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
Zhang L; Department of Pathology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan 750000, China.
Yuan Y; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China.
Wang Y; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China.
Li G; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China; NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 750004, China.
Yang X; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China; NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 750004, China. Electronic address: .
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Źródło:
Cellular signalling [Cell Signal] 2023 Jun; Vol. 106, pp. 110627. Date of Electronic Publication: 2023 Feb 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Atherosclerosis*/metabolism
Homocysteine*/pharmacology
Cells, Cultured ; DNA Methylation ; Forkhead Box Protein O1/metabolism ; Inflammation/genetics ; rap1 GTP-Binding Proteins/genetics ; rap1 GTP-Binding Proteins/metabolism ; Animals ; Mice
Czasopismo naukowe
Tytuł:
CAP1 (cyclase-associated protein 1) mediates the cyclic AMP signals that activate Rap1 in stimulating matrix adhesion of colon cancer cells.
Autorzy:
Ramsey A; Department of Biological Sciences, Arkansas State University, State University, AR 72467, USA.
Akana L; Department of Biological Sciences, Arkansas State University, State University, AR 72467, USA.
Miyajima E; Department of Biological Sciences, Arkansas State University, State University, AR 72467, USA.
Douglas S; Department of Biological Sciences, Arkansas State University, State University, AR 72467, USA.
Gray J; Department of Biological Sciences, Arkansas State University, State University, AR 72467, USA.
Rowland A; Department of Biological Sciences, Arkansas State University, State University, AR 72467, USA.
Sharma KD; Molecular Biosciences Graduate Program, Arkansas State University, State University, AR 72467, USA.
Xu J; Molecular Biosciences Graduate Program, Arkansas State University, State University, AR 72467, USA; Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR 72401, USA; College of Agriculture, Arkansas State University, State University, AR 72467, USA.
Xie JY; Molecular Biosciences Graduate Program, Arkansas State University, State University, AR 72467, USA; Department of Basic Sciences, New York Institute of Technology College of Osteopathic Medicine at Arkansas State University, Jonesboro, AR 72401, USA.
Zhou GL; Department of Biological Sciences, Arkansas State University, State University, AR 72467, USA; Molecular Biosciences Graduate Program, Arkansas State University, State University, AR 72467, USA. Electronic address: .
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Źródło:
Cellular signalling [Cell Signal] 2023 Apr; Vol. 104, pp. 110589. Date of Electronic Publication: 2023 Jan 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Cyclic AMP*/metabolism
Colonic Neoplasms*
Animals ; Signal Transduction/physiology ; Guanine Nucleotide Exchange Factors/metabolism ; rap1 GTP-Binding Proteins/genetics ; rap1 GTP-Binding Proteins/metabolism ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
Epac-1/Rap-1 signaling pathway orchestrates the reno-therapeutic effect of ticagrelor against renal ischemia/reperfusion model.
Autorzy:
El-Mokadem BM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt.
El-Abhar HS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Abdallah DM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address: .
Awad AS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt.
Soubh AA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt.
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Źródło:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jul; Vol. 139, pp. 111488. Date of Electronic Publication: 2021 May 03.
Typ publikacji:
Journal Article
MeSH Terms:
Acute Kidney Injury/*drug therapy
Guanine Nucleotide Exchange Factors/*drug effects
Purinergic P2Y Receptor Antagonists/*therapeutic use
Reperfusion Injury/*drug therapy
Signal Transduction/*drug effects
Ticagrelor/*therapeutic use
rap1 GTP-Binding Proteins/*drug effects
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Guanine Nucleotide Exchange Factors/antagonists & inhibitors ; Ischemia ; Kidney Function Tests ; Male ; Rats ; Rats, Wistar ; Renal Circulation/drug effects ; rap1 GTP-Binding Proteins/antagonists & inhibitors
Czasopismo naukowe
Tytuł:
Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2 and RAP1.
Autorzy:
Rai R; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, 330 Cedar Street, CT, 06520, USA. .
Biju K; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, 330 Cedar Street, CT, 06520, USA.; Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Sun W; State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.; University of Chinese Academy of Sciences, 100049, Beijing, China.
Sodeinde T; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, 330 Cedar Street, CT, 06520, USA.
Al-Hiyasat A; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, 330 Cedar Street, CT, 06520, USA.
Morgan J; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, 330 Cedar Street, CT, 06520, USA.
Ye X; University of Chinese Academy of Sciences, 100049, Beijing, China.; School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai, 201210, China.
Li X; State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.; University of Chinese Academy of Sciences, 100049, Beijing, China.
Chen Y; State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.; University of Chinese Academy of Sciences, 100049, Beijing, China.; School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai, 201210, China.
Chang S; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, 330 Cedar Street, CT, 06520, USA. .; Department of Pathology, Yale University School of Medicine, 330 Cedar Street, New Haven, CT, 06520, USA. .; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 330 Cedar Street, New Haven, CT, 06520, USA. .
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Źródło:
Nature communications [Nat Commun] 2023 Apr 14; Vol. 14 (1), pp. 2144. Date of Electronic Publication: 2023 Apr 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Nuclear Envelope*/metabolism
Telomeric Repeat Binding Protein 2*/genetics
Telomeric Repeat Binding Protein 2*/metabolism
Lamin Type A/metabolism ; Telomere/genetics ; Telomere/metabolism ; Telomere-Binding Proteins/metabolism ; rap1 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
Natural Killer Cell Transcript 4 promotes the development of Sjӧgren's syndrome via activation of Rap1 on B cells.
Autorzy:
Qu P; Center for Cancer Research, National Cancer Institute, USA. Electronic address: .
Wuest T; Center for Cancer Research, National Cancer Institute, USA.
Min Y; Center for Cancer Research, National Cancer Institute, USA.
Alevizos I; Sjӧgren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, National Institute of Health, USA.
Young HA; Center for Cancer Research, National Cancer Institute, USA.
Lin PC; Center for Cancer Research, National Cancer Institute, USA. Electronic address: .
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Źródło:
Journal of autoimmunity [J Autoimmun] 2021 Jan; Vol. 116, pp. 102559. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms:
B-Lymphocytes/*immunology
Interleukins/*immunology
Sjogren's Syndrome/*immunology
rap1 GTP-Binding Proteins/*immunology
Adult ; Aged ; Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Movement/immunology ; Cells, Cultured ; Chemokine CXCL13/genetics ; Chemokine CXCL13/immunology ; Chemokine CXCL13/metabolism ; Endothelial Cells/cytology ; Endothelial Cells/immunology ; Endothelial Cells/metabolism ; Female ; Flow Cytometry/methods ; Humans ; Interleukins/genetics ; Interleukins/metabolism ; Male ; Mice, Transgenic ; Middle Aged ; Salivary Glands/immunology ; Salivary Glands/metabolism ; Sjogren's Syndrome/genetics ; Sjogren's Syndrome/metabolism ; Young Adult ; rap1 GTP-Binding Proteins/genetics ; rap1 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
Rap1 in the VMH regulates glucose homeostasis.
Autorzy:
Kaneko K; Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan.
Lin HY; Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Fu Y; Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Saha PK; Department of Medicine and.
De la Puente-Gomez AB; Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Xu Y; Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Ohinata K; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan.
Chen P; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Morozov A; Unit on Behavioral Genetics, Laboratory of Molecular Pathophysiology, National Institute of Mental Health, NIH, Maryland, USA.; Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA.
Fukuda M; Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
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Źródło:
JCI insight [JCI Insight] 2021 Jun 08; Vol. 6 (11). Date of Electronic Publication: 2021 Jun 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Blood Glucose/*metabolism
Hyperglycemia/*metabolism
Insulin/*metabolism
Neurons/*metabolism
Obesity/*metabolism
Ventromedial Hypothalamic Nucleus/*metabolism
rap1 GTP-Binding Proteins/*metabolism
Animals ; Diet, High-Fat ; Gene Knockdown Techniques ; Homeostasis ; Hypothalamus/metabolism ; Insulin Resistance ; Leptin/metabolism ; Mice ; Steroidogenic Factor 1/metabolism ; rap1 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł:
Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population.
Autorzy:
Ishihara S; Department of Biosciences, School of Science, Kitasato University, Sagamihara, Japan.
Sato T; Department of Biosciences, School of Science, Kitasato University, Sagamihara, Japan.
Sugioka R; Department of Biosciences, School of Science, Kitasato University, Sagamihara, Japan.
Miwa R; Department of Biosciences, School of Science, Kitasato University, Sagamihara, Japan.
Saito H; Department of Biosciences, School of Science, Kitasato University, Sagamihara, Japan.
Sato R; Laboratory of Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Fukuyama H; Laboratory of Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Nakajima A; Department of Basic Science, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan.
Sawai S; Department of Basic Science, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan.
Kotani A; Department of Hematological Malignancy, Institute of Medical Science, Tokai University, Isehara, Japan.
Katagiri K; Department of Biosciences, School of Science, Kitasato University, Sagamihara, Japan.
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Źródło:
Frontiers in immunology [Front Immunol] 2021 Jun 01; Vol. 12, pp. 624419. Date of Electronic Publication: 2021 Jun 01 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemotaxis, Leukocyte*/drug effects
B-Lymphocytes/*metabolism
Germinal Center/*metabolism
rap GTP-Binding Proteins/*metabolism
rap1 GTP-Binding Proteins/*metabolism
Animals ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Chemokine CXCL12/pharmacology ; Germinal Center/cytology ; Germinal Center/drug effects ; Germinal Center/immunology ; Immunity, Humoral ; Immunization ; Intercellular Adhesion Molecule-1/metabolism ; Liver/immunology ; Liver/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Precursor Cells, B-Lymphoid/immunology ; Precursor Cells, B-Lymphoid/metabolism ; Spleen/immunology ; Spleen/metabolism ; Vascular Cell Adhesion Molecule-1/metabolism ; gamma-Globulins/pharmacology ; rap GTP-Binding Proteins/genetics ; rap1 GTP-Binding Proteins/genetics ; Mice
Czasopismo naukowe
Tytuł:
Rap1a Regulates Cardiac Fibroblast Contraction of 3D Diabetic Collagen Matrices by Increased Activation of the AGE/RAGE Cascade.
Autorzy:
Burr SD; Department of BioMolecular Sciences, University of Mississippi School of Pharmacy, University, MS 38677, USA.
Stewart JA Jr; Department of BioMolecular Sciences, University of Mississippi School of Pharmacy, University, MS 38677, USA.
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Źródło:
Cells [Cells] 2021 May 22; Vol. 10 (6). Date of Electronic Publication: 2021 May 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Collagen/*metabolism
Diabetes Mellitus, Experimental/*metabolism
Fibroblasts/*metabolism
Receptor for Advanced Glycation End Products/*metabolism
rap1 GTP-Binding Proteins/*metabolism
Animals ; Extracellular Matrix/metabolism ; Glycation End Products, Advanced/metabolism ; Mice, Transgenic ; Myofibroblasts/metabolism ; Oxidative Stress/physiology ; rap1 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł:
Optogenetics-based localization of talin to the plasma membrane promotes activation of β3 integrins.
Autorzy:
Liao Z; Department of Medicine, University of California, San Diego, La Jolla, California, USA. Electronic address: .
Gingras AR; Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Lagarrigue F; Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Ginsberg MH; Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Shattil SJ; Department of Medicine, University of California, San Diego, La Jolla, California, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100675. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Optogenetics*
Cell Membrane/*metabolism
Cytoplasm/*metabolism
Endothelial Cells/*metabolism
Platelet Glycoprotein GPIIb-IIIa Complex/*metabolism
Talin/*metabolism
rap1 GTP-Binding Proteins/*metabolism
Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Mice ; Platelet Glycoprotein GPIIb-IIIa Complex/genetics ; Protein Binding ; Talin/genetics ; rap1 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł:
miR-590-3p Alleviates diabetic peripheral neuropathic pain by targeting RAP1A and suppressing infiltration by the T cells.
Autorzy:
Wu Y; Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, 215000, China.
Gu Y; Department of Endocrinology, Shanghai International Medical Center, Shanghai, 200318, China.
Shi B; Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, 215000, China.
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Źródło:
Acta biochimica Polonica [Acta Biochim Pol] 2020 Dec 17; Vol. 67 (4), pp. 587-593.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2/*genetics
Diabetic Neuropathies/*genetics
MicroRNAs/*genetics
Neuralgia/*genetics
T-Lymphocytes/*immunology
rap1 GTP-Binding Proteins/*genetics
Animals ; Antagomirs/genetics ; Antagomirs/metabolism ; Base Pairing ; Base Sequence ; Cell Movement ; Cell Proliferation ; Diabetes Mellitus, Type 2/immunology ; Diabetes Mellitus, Type 2/pathology ; Diabetic Neuropathies/immunology ; Diabetic Neuropathies/pathology ; Disease Models, Animal ; Ganglia, Spinal/immunology ; Ganglia, Spinal/pathology ; Gene Expression Regulation ; Genes, Reporter ; Interleukin-1beta/genetics ; Interleukin-1beta/immunology ; Interleukin-6/genetics ; Interleukin-6/immunology ; Luciferases/genetics ; Luciferases/metabolism ; Male ; Mice ; MicroRNAs/agonists ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/immunology ; Neuralgia/immunology ; Neuralgia/pathology ; Neuralgia/prevention & control ; Oligoribonucleotides/genetics ; Oligoribonucleotides/metabolism ; Signal Transduction ; T-Lymphocytes/pathology ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology ; rap1 GTP-Binding Proteins/immunology
Czasopismo naukowe
Tytuł:
The Mystery of Rap1 Suppression of Oncogenic Ras.
Autorzy:
Nussinov R; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: .
Jang H; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Zhang M; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Tsai CJ; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Sablina AA; VIB Center for the Biology of Disease and KU Leuven Department of Oncology, Leuven Cancer Institute, Leuven, Belgium.
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Źródło:
Trends in cancer [Trends Cancer] 2020 May; Vol. 6 (5), pp. 369-379. Date of Electronic Publication: 2020 Mar 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Neoplasms/*pathology
Proto-Oncogene Proteins c-raf/*metabolism
Proto-Oncogene Proteins p21(ras)/*metabolism
rap1 GTP-Binding Proteins/*metabolism
Crystallography ; Humans ; MAP Kinase Signaling System ; Models, Molecular ; Protein Binding ; Protein Domains ; Proto-Oncogene Proteins B-raf/metabolism ; Proto-Oncogene Proteins B-raf/ultrastructure ; Proto-Oncogene Proteins c-raf/ultrastructure ; Proto-Oncogene Proteins p21(ras)/ultrastructure ; rap GTP-Binding Proteins/metabolism ; rap1 GTP-Binding Proteins/ultrastructure
Czasopismo naukowe
Tytuł:
Excitotoxic targeting of Kidins220 to the Golgi apparatus precedes calpain cleavage of Rap1-activation complexes.
Autorzy:
López-Menéndez C; Instituto de Investigaciones Biomédicas 'Alberto Sols', Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, C/ Valderrebollo, 5, 28031, Madrid, Spain.
Simón-García A; Instituto de Investigaciones Biomédicas 'Alberto Sols', Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, C/ Valderrebollo, 5, 28031, Madrid, Spain.
Gamir-Morralla A; Instituto de Investigaciones Biomédicas 'Alberto Sols', Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, C/ Valderrebollo, 5, 28031, Madrid, Spain.; Institute of Physiological Chemistry, University Medical Center, Johannes Gutenberg University Mainz, Hanns-Dieter-Hüsch-Weg 19, 55128, Mainz, Germany.
Pose-Utrilla J; Instituto de Investigaciones Biomédicas 'Alberto Sols', Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, C/ Valderrebollo, 5, 28031, Madrid, Spain.
Luján R; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Dept. Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/ Almansa 14, 02008, Albacete, Spain.
Mochizuki N; Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan.
Díaz-Guerra M; Instituto de Investigaciones Biomédicas 'Alberto Sols', Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), C/ Arturo Duperier, 4, 28029, Madrid, Spain.
Iglesias T; Instituto de Investigaciones Biomédicas 'Alberto Sols', Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), C/ Arturo Duperier, 4, 28029, Madrid, Spain. .; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, C/ Valderrebollo, 5, 28031, Madrid, Spain. .
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Źródło:
Cell death & disease [Cell Death Dis] 2019 Jul 11; Vol. 10 (7), pp. 535. Date of Electronic Publication: 2019 Jul 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calpain/*metabolism
Golgi Apparatus/*metabolism
Membrane Proteins/*metabolism
Neurons/*metabolism
Phosphoproteins/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
rap1 GTP-Binding Proteins/*metabolism
Animals ; Calpain/antagonists & inhibitors ; Cell Death/drug effects ; Cell Death/genetics ; Cells, Cultured ; Endocytosis/drug effects ; Endocytosis/genetics ; Endosomes/metabolism ; Glutamic Acid/metabolism ; Golgi Apparatus/drug effects ; Membrane Proteins/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Neurons/drug effects ; Neurons/enzymology ; Neurons/ultrastructure ; Phosphoproteins/genetics ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/genetics ; Signal Transduction/genetics ; rab5 GTP-Binding Proteins/metabolism ; rap1 GTP-Binding Proteins/antagonists & inhibitors ; rap1 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł:
Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.
Autorzy:
Mutvei AP; Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building, 413 E. 69th St., New York, NY, 10021, USA. .; Karolinska Institutet, Department of Microbiology, Tumor and Cell biology, Nobels väg 16, KI Solna Campus Karolinska Institutet, Box 280, SE-171 77, Stockholm, Sweden. .; Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85, Uppsala, Sweden. .
Nagiec MJ; Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building, 413 E. 69th St., New York, NY, 10021, USA.
Hamann JC; Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building, 413 E. 69th St., New York, NY, 10021, USA.
Kim SG; Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building, 413 E. 69th St., New York, NY, 10021, USA.
Vincent CT; Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85, Uppsala, Sweden.; Department of Microbiology, New York University School of Medicine, New York, NY, USA.
Blenis J; Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building, 413 E. 69th St., New York, NY, 10021, USA. .
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Źródło:
Nature communications [Nat Commun] 2020 Mar 17; Vol. 11 (1), pp. 1416. Date of Electronic Publication: 2020 Mar 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Amino Acids/*metabolism
Lysosomes/*metabolism
Mechanistic Target of Rapamycin Complex 1/*metabolism
rap GTP-Binding Proteins/*metabolism
rap1 GTP-Binding Proteins/*metabolism
Humans ; Lysosomes/enzymology ; Lysosomes/genetics ; Mechanistic Target of Rapamycin Complex 1/genetics ; Signal Transduction ; rap GTP-Binding Proteins/genetics ; rap1 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł:
How CBP/Shank3 Guards Rap and H-Ras.
Autorzy:
Chowdhury D; Department of Pharmacology, University of California at Davis, 451 Health Sciences Dr., Davis, CA 95616, USA. Electronic address: .
Hell JW; Department of Pharmacology, University of California at Davis, 451 Health Sciences Dr., Davis, CA 95616, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2020 Mar 03; Vol. 28 (3), pp. 274-276.
Typ publikacji:
Journal Article; Comment
MeSH Terms:
rap1 GTP-Binding Proteins*
ras Proteins*
rap GTP-Binding Proteins
Czasopismo naukowe
Tytuł:
Integration of Rap1 and Calcium Signaling.
Autorzy:
Kosuru R; Versiti Blood Research Institute, Milwaukee, WI 53201, USA.
Chrzanowska M; Versiti Blood Research Institute, Milwaukee, WI 53201, USA.; Department of Pharmacology and Toxicology, Medical College of Wisconsin, PO Box 2178, Milwaukee, WI 53201-2178, USA.; Cardiovascular Center, Medical College of Wisconsin, PO Box 2178, Milwaukee, WI 53201-2178, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Feb 27; Vol. 21 (5). Date of Electronic Publication: 2020 Feb 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Calcium/*metabolism
Calcium Signaling/*genetics
Cardiomegaly/*metabolism
Neurodegenerative Diseases/*metabolism
rap1 GTP-Binding Proteins/*metabolism
Animals ; Ca(2+) Mg(2+)-ATPase/genetics ; Ca(2+) Mg(2+)-ATPase/metabolism ; Ca(2+) Mg(2+)-ATPase/physiology ; Cardiomegaly/genetics ; Cyclic AMP/metabolism ; Diglycerides/metabolism ; Endothelium/metabolism ; Endothelium/physiology ; Humans ; Integrins/genetics ; Integrins/metabolism ; Muscle, Smooth, Vascular/metabolism ; Neurodegenerative Diseases/genetics ; Toll-Like Receptors/immunology ; Vasodilation/genetics ; Vasodilation/physiology ; rap1 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł:
Rap1 is Involved in Angiopoietin-1-Induced Cell-Cell Junction Stabilization and Endothelial Cell Sprouting.
Autorzy:
Gaonac'h-Lovejoy V; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada.
Boscher C; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada.
Delisle C; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada.
Gratton JP; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada.
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Źródło:
Cells [Cells] 2020 Jan 08; Vol. 9 (1). Date of Electronic Publication: 2020 Jan 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Adhesion*
Cell Communication*
Angiopoietin-1/*pharmacology
Aorta/*physiology
Endothelium, Vascular/*physiology
rap1 GTP-Binding Proteins/*metabolism
Animals ; Aorta/cytology ; Aorta/drug effects ; Cattle ; Cells, Cultured ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Signal Transduction ; rap1 GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł:
Optimal Inhibition of Choroidal Neovascularization by scAAV2 with VMD2 Promoter-driven Active Rap1a in the RPE.
Autorzy:
Wang H; John A Moran Eye Center, Salt Lake City, UT, 84132, USA.
Kunz E; John A Moran Eye Center, Salt Lake City, UT, 84132, USA.
Stoddard GJ; Department of Internal Medicine, University of Utah, Salt Lake City, UT, 84132, USA.
Hauswirth WW; Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Hartnett ME; John A Moran Eye Center, Salt Lake City, UT, 84132, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Oct 31; Vol. 9 (1), pp. 15732. Date of Electronic Publication: 2019 Oct 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Bestrophins/*genetics
Choroidal Neovascularization/*therapy
Genetic Vectors/*metabolism
Parvovirinae/*genetics
Retinal Pigment Epithelium/*metabolism
rap1 GTP-Binding Proteins/*metabolism
Animals ; Autophagy ; Caspase 3/metabolism ; Choroidal Neovascularization/pathology ; Dependovirus ; Disease Models, Animal ; Female ; Genetic Vectors/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Microtubule-Associated Proteins/metabolism ; NF-kappa B/metabolism ; Promoter Regions, Genetic ; Retinal Pigment Epithelium/cytology ; Vascular Endothelial Growth Factor A/metabolism ; rap1 GTP-Binding Proteins/genetics
SCR Organism:
Adeno-associated virus-2
Czasopismo naukowe

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