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Tytuł :
Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems.
Autorzy :
Yu TC; Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA.
Liu WL; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.
Brinck MS; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, 90095, USA.
Davis JE; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.
Shek J; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.
Bower G; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.
Einav T; Department of Physics, California Institute of Technology, Pasadena, CA, 91125, USA.
Insigne KD; Bioinformatics Interdepartmental Graduate Program, University of California, Los Angeles, CA, 90095, USA.
Phillips R; Department of Physics, California Institute of Technology, Pasadena, CA, 91125, USA.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.; Department of Applied Physics, California Institute of Technology, Pasadena, CA, 91125, USA.
Kosuri S; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA. .; UCLA-DOE Institute for Genomics and Proteomics, Los Angeles, CA, 90095, USA. .; Institute for Quantitative and Computational Biosciences (QCB), University of California, Los Angeles, Los Angeles, CA, 90095, USA. .; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, 90095, USA. .; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, 90095, USA. .; Molecular Biology Interdepartmental Doctoral Program, University of California, Los Angeles, CA, 90095, USA. .
Urtecho G; Molecular Biology Interdepartmental Doctoral Program, University of California, Los Angeles, CA, 90095, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 12; Vol. 12 (1), pp. 325. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Logic*
Promoter Regions, Genetic*
Isopropyl Thiogalactoside/*pharmacology
Binding Sites ; Biophysical Phenomena ; DNA-Directed RNA Polymerases/metabolism ; Escherichia coli/drug effects ; Escherichia coli/metabolism ; Fluorescence ; Genes, Reporter ; Mutation/genetics ; Operator Regions, Genetic/genetics ; Protein Binding ; Reproducibility of Results ; Thermodynamics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
The critical region for viral RNA encapsidation in leader promoter of Nipah virus.
Autorzy :
Pong LY; Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor Darul Ehsan, Malaysia.; Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia.
Rabu A; Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor Darul Ehsan, Malaysia.
Ibrahim N; Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor Darul Ehsan, Malaysia. .
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Źródło :
Molecular genetics and genomics : MGG [Mol Genet Genomics] 2020 Nov; Vol. 295 (6), pp. 1501-1516. Date of Electronic Publication: 2020 Aug 07.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Viral*
Promoter Regions, Genetic*
RNA, Viral*/physiology
Virus Assembly*
Nipah Virus/*genetics
5' Untranslated Regions ; Cell Line ; Mutagenesis ; Nucleocapsid Proteins/genetics ; RNA, Messenger ; Recombinant Proteins/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Genome-Wide Identification and Characterization of UTR-Introns of Citrus sinensis .
Autorzy :
Shi X; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Wu J; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Mensah RA; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Tian N; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Liu J; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Liu F; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Chen J; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Che J; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Guo Y; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Wu B; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Zhong G; Institute of Fruit Tree Research, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.
Cheng C; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 27; Vol. 21 (9). Date of Electronic Publication: 2020 Apr 27.
Typ publikacji :
Journal Article
MeSH Terms :
Genome, Plant*
Genome-Wide Association Study*/methods
Introns*
Untranslated Regions*
Citrus sinensis/*genetics
3' Untranslated Regions ; 5' Untranslated Regions ; Alternative Splicing ; Chromosome Mapping ; Genomics/methods ; Open Reading Frames ; RNA Splice Sites ; Regulatory Sequences, Nucleic Acid
Czasopismo naukowe
Tytuł :
Obtaining a series of native gradient promoter-5'-UTR sequences in Corynebacterium glutamicum ATCC 13032.
Autorzy :
Li N; Key Laboratory of Industrial Biotechnology, Ministry of Education and School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China.; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China.; Jiangsu Provisional Research Center for Bioactive Product Processing Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China.
Zeng W; Key Laboratory of Industrial Biotechnology, Ministry of Education and School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China.; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China.; Jiangsu Provisional Research Center for Bioactive Product Processing Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China.
Xu S; Key Laboratory of Industrial Biotechnology, Ministry of Education and School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China.; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China.; Jiangsu Provisional Research Center for Bioactive Product Processing Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China.
Zhou J; Key Laboratory of Industrial Biotechnology, Ministry of Education and School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China. .; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China. .; Jiangsu Provisional Research Center for Bioactive Product Processing Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China. .
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Źródło :
Microbial cell factories [Microb Cell Fact] 2020 Jun 03; Vol. 19 (1), pp. 120. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article
MeSH Terms :
Corynebacterium glutamicum*/genetics
Corynebacterium glutamicum*/metabolism
Gene Expression Regulation, Bacterial*
Metabolic Engineering*
Promoter Regions, Genetic*
5' Untranslated Regions ; Genes, Bacterial ; Luminescent Proteins/biosynthesis
Czasopismo naukowe
Tytuł :
Coding and noncoding somatic mutations in candidate genes in basal cell carcinoma.
Autorzy :
Maturo MG; Department of Dermatology, Department of Biotechnology and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Rachakonda S; Division of Functional Genome Analysis, German Cancer Research Center, Heidelberg, Germany.; Division of Molecular Genetic epidemiology, German Cancer Research Center, Heidelberg, Germany.
Heidenreich B; Division of Molecular Genetic epidemiology, German Cancer Research Center, Heidelberg, Germany.
Pellegrini C; Department of Dermatology, Department of Biotechnology and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Srinivas N; Division of Functional Genome Analysis, German Cancer Research Center, Heidelberg, Germany.
Requena C; Department of Dermatology, Instituto Valenciano de Oncología, València, Spain.
Serra-Guillen C; Department of Dermatology, Instituto Valenciano de Oncología, València, Spain.
Llombart B; Department of Dermatology, Instituto Valenciano de Oncología, València, Spain.
Sanmartin O; Department of Dermatology, Instituto Valenciano de Oncología, València, Spain.
Guillen C; Department of Dermatology, Instituto Valenciano de Oncología, València, Spain.
Di Nardo L; Institute of Dermatology, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Peris K; Institute of Dermatology, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Fargnoli MC; Department of Dermatology, Department of Biotechnology and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Nagore E; Department of Dermatology, Instituto Valenciano de Oncología, València, Spain.
Kumar R; Division of Functional Genome Analysis, German Cancer Research Center, Heidelberg, Germany. .; Division of Molecular Genetic epidemiology, German Cancer Research Center, Heidelberg, Germany. .
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Źródło :
Scientific reports [Sci Rep] 2020 May 14; Vol. 10 (1), pp. 8005. Date of Electronic Publication: 2020 May 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers, Tumor*
Mutation*
Open Reading Frames*
Untranslated Regions*
Carcinoma, Basal Cell/*genetics
DNA Methylation ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Humans ; Promoter Regions, Genetic ; Skin Neoplasms/genetics
Czasopismo naukowe
Tytuł :
The Impact of Leadered and Leaderless Gene Structures on Translation Efficiency, Transcript Stability, and Predicted Transcription Rates in Mycobacterium smegmatis.
Autorzy :
Nguyen TG; Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
Vargas-Blanco DA; Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
Roberts LA; Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
Shell SS; Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, Massachusetts, USA .; Program in Bioinformatics and Computational Biology, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
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Źródło :
Journal of bacteriology [J Bacteriol] 2020 Apr 09; Vol. 202 (9). Date of Electronic Publication: 2020 Apr 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
5' Untranslated Regions*
Protein Biosynthesis*
Bacterial Proteins/*genetics
Mycobacterium smegmatis/*genetics
Sigma Factor/*genetics
Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Genes, Reporter ; Humans ; Mycobacterium Infections, Nontuberculous/microbiology ; Mycobacterium smegmatis/chemistry ; Mycobacterium smegmatis/metabolism ; Promoter Regions, Genetic ; RNA Stability ; Sigma Factor/chemistry ; Sigma Factor/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Exchange of endogenous and heterogeneous yeast terminators in Pichia pastoris to tune mRNA stability and gene expression.
Autorzy :
Ito Y; Graduate School of Science, Technology and Innovation, Kobe University, Kobe 657-8501, Japan.; Engineering Biology Research Center, Kobe University, Kobe 657-8501, Japan.
Terai G; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8561, Japan.
Ishigami M; Technology Research Association of Highly Efficient Gene Design, Kobe 650-0047, Japan.
Hashiba N; Technology Research Association of Highly Efficient Gene Design, Kobe 650-0047, Japan.
Nakamura Y; Graduate School of Science, Technology and Innovation, Kobe University, Kobe 657-8501, Japan.; Engineering Biology Research Center, Kobe University, Kobe 657-8501, Japan.
Bamba T; Graduate School of Science, Technology and Innovation, Kobe University, Kobe 657-8501, Japan.
Kumokita R; Graduate School of Science, Technology and Innovation, Kobe University, Kobe 657-8501, Japan.
Hasunuma T; Graduate School of Science, Technology and Innovation, Kobe University, Kobe 657-8501, Japan.; Engineering Biology Research Center, Kobe University, Kobe 657-8501, Japan.
Asai K; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8561, Japan.
Ishii J; Graduate School of Science, Technology and Innovation, Kobe University, Kobe 657-8501, Japan.; Engineering Biology Research Center, Kobe University, Kobe 657-8501, Japan.
Kondo A; Graduate School of Science, Technology and Innovation, Kobe University, Kobe 657-8501, Japan.; Engineering Biology Research Center, Kobe University, Kobe 657-8501, Japan.; Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe 657-8501, Japan.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 16; Vol. 48 (22), pp. 13000-13012.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Stability/*genetics
RNA, Messenger/*genetics
Saccharomycetales/*genetics
Terminator Regions, Genetic/*genetics
Gene Expression Regulation, Fungal/genetics ; Metabolic Engineering ; Promoter Regions, Genetic ; Saccharomyces cerevisiae/genetics ; Synthetic Biology
SCR Organism :
Komagataella pastoris; Komagataella phaffii
Czasopismo naukowe
Tytuł :
The novel TP53 3'-end methylation pattern associated with its expression would be a potential biomarker for breast cancer detection.
Autorzy :
Zeng F; Department of Emergency, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Heng J; Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, 410013, China.; School of Life Sciences, Central South University, Changsha, 410013, Hunan, China.
Guo X; Sansure Biotech Inc., Changsha, 410205, Hunan, China.
Wang Y; School of Life Sciences, Central South University, Changsha, 410013, Hunan, China.
Wu W; School of Life Sciences, Central South University, Changsha, 410013, Hunan, China.
Tang L; Department of Breast Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Chen M; Sansure Biotech Inc., Changsha, 410205, Hunan, China.
Wang S; Department of Breast Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Deng H; Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, 410013, China.
Wang J; School of Life Sciences, Central South University, Changsha, 410013, Hunan, China. .; Sansure Biotech Inc., Changsha, 410205, Hunan, China. .; Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. .
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Źródło :
Breast cancer research and treatment [Breast Cancer Res Treat] 2020 Feb; Vol. 180 (1), pp. 237-245. Date of Electronic Publication: 2020 Jan 25.
Typ publikacji :
Journal Article
MeSH Terms :
3' Untranslated Regions*
Biomarkers, Tumor*
DNA Methylation*
Gene Expression Regulation, Neoplastic*
Breast Neoplasms/*diagnosis
Breast Neoplasms/*genetics
Tumor Suppressor Protein p53/*genetics
Adenosine Triphosphatases/genetics ; Adult ; Aged ; Cation Transport Proteins/genetics ; Cell Adhesion Molecules, Neuronal/genetics ; CpG Islands ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Middle Aged ; Mutation ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Promoter Regions, Genetic ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
APC transcription studies and molecular diagnosis of familial adenomatous polyposis.
Autorzy :
Short E; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, CF14 4XW, UK. .; Department of Cellular Pathology, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK. .
Thomas LE; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, CF14 4XW, UK.
Davies A; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, CF14 4XW, UK.
Bolton A; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, CF14 4XW, UK.
Maynard J; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, CF14 4XW, UK.
Giles P; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, CF14 4XW, UK.
Mort M; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, CF14 4XW, UK.
Consoli C; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, CF14 4XW, UK.
Egner I; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, CF14 4XW, UK.
Jundi H; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, CF14 4XW, UK.
Sampson JR; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, CF14 4XW, UK.
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Źródło :
European journal of human genetics : EJHG [Eur J Hum Genet] 2020 Jan; Vol. 28 (1), pp. 118-121. Date of Electronic Publication: 2019 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Promoter Regions, Genetic*
Adenomatous Polyposis Coli/*genetics
Adenomatous Polyposis Coli Protein/*genetics
5' Untranslated Regions ; Adenomatous Polyposis Coli/diagnosis ; Adenomatous Polyposis Coli Protein/metabolism ; Humans ; Pedigree ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites.
Autorzy :
Promonet A; Institut de Génétique Humaine, CNRS et Université de Montpellier, Equipe labélisée Ligue contre le Cancer, Montpellier, France.
Padioleau I; Institut de Génétique Humaine, CNRS et Université de Montpellier, Equipe labélisée Ligue contre le Cancer, Montpellier, France.; Institut Gustave Roussy, Villejuif, France.
Liu Y; Institut Curie, PSL Research University, CNRS, UMR3244, Sorbonne Université, Paris, France.
Sanz L; Department of Molecular and Cellular Biology, University of California, Davis, CA, 95616, USA.
Biernacka A; Laboratory of Bioinformatics and Systems Biology, Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Schmitz AL; Institut de Génétique Humaine, CNRS et Université de Montpellier, Equipe labélisée Ligue contre le Cancer, Montpellier, France.
Skrzypczak M; Laboratory of Bioinformatics and Systems Biology, Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Sarrazin A; BioCampus Montpellier, CNRS et Université de Montpellier, Montpellier, France.
Mettling C; Institut de Génétique Humaine, CNRS et Université de Montpellier, Montpellier, France.
Rowicka M; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Ginalski K; Laboratory of Bioinformatics and Systems Biology, Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Chedin F; Department of Molecular and Cellular Biology, University of California, Davis, CA, 95616, USA.
Chen CL; Institut Curie, PSL Research University, CNRS, UMR3244, Sorbonne Université, Paris, France. .
Lin YL; Institut de Génétique Humaine, CNRS et Université de Montpellier, Equipe labélisée Ligue contre le Cancer, Montpellier, France. .
Pasero P; Institut de Génétique Humaine, CNRS et Université de Montpellier, Equipe labélisée Ligue contre le Cancer, Montpellier, France. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 07; Vol. 11 (1), pp. 3940. Date of Electronic Publication: 2020 Aug 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Replication*
Transcription, Genetic*
DNA Topoisomerases, Type I/*metabolism
R-Loop Structures/*genetics
Terminator Regions, Genetic/*genetics
Ataxia Telangiectasia Mutated Proteins/metabolism ; DNA Breaks, Double-Stranded ; DNA Topoisomerases, Type I/genetics ; Gene Knockdown Techniques ; Genomic Instability ; HEK293 Cells ; HeLa Cells ; Humans ; Phosphorylation ; Promoter Regions, Genetic ; RNA, Small Interfering/metabolism
Czasopismo naukowe
Tytuł :
Gene autoregulation by 3' UTR-derived bacterial small RNAs.
Autorzy :
Hoyos M; Friedrich Schiller University Jena, Institute of Microbiology, Jena, Germany.; Faculty of Biology I, Ludwig-Maximilians-University of Munich, Martinsried, Germany.
Huber M; Friedrich Schiller University Jena, Institute of Microbiology, Jena, Germany.; Faculty of Biology I, Ludwig-Maximilians-University of Munich, Martinsried, Germany.
Förstner KU; TH Köln - University of Applied Sciences, Institute of Information Science, Cologne, Germany.; ZB MED - Information Centre for Life Sciences, Cologne, Germany.
Papenfort K; Friedrich Schiller University Jena, Institute of Microbiology, Jena, Germany.; Faculty of Biology I, Ludwig-Maximilians-University of Munich, Martinsried, Germany.; Microverse Cluster, Friedrich Schiller University Jena, Jena, Germany.
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Źródło :
ELife [Elife] 2020 Aug 03; Vol. 9. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Bacterial*
3' Untranslated Regions/*physiology
RNA, Bacterial/*physiology
RNA, Small Untranslated/*physiology
Vibrio cholerae/*genetics
Endoribonucleases/metabolism ; Feedback, Physiological ; Protein Biosynthesis ; RNA-Seq ; Rho Factor/metabolism ; Terminator Regions, Genetic ; Vibrio cholerae/enzymology
Czasopismo naukowe
Tytuł :
Genetic variants of VEGFR-1 gene promoter in acute myocardial infarction.
Autorzy :
Wang H; Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, 272029, Shandong, China.
Zhang S; Division of Cardiology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
Wang N; Division of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
Zhang J; Division of Cardiology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
Chen M; Division of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
He X; Division of Cardiology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
Cui Y; Cardiac Care Unit, Affiliated Hospital of Jining Medical Uniiversity, Jining Medical University, Jining, Shandong, China.
Pang S; Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, 272029, Shandong, China. .
Yan B; Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, 272029, Shandong, China. .
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Źródło :
Human genomics [Hum Genomics] 2019 Nov 19; Vol. 13 (1), pp. 56. Date of Electronic Publication: 2019 Nov 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Variation*
Promoter Regions, Genetic*
Myocardial Infarction/*genetics
Vascular Endothelial Growth Factor Receptor-1/*genetics
5' Untranslated Regions/genetics ; Adult ; Aged ; Aged, 80 and over ; Animals ; Base Sequence ; Binding Sites ; Biotinylation ; Case-Control Studies ; Female ; Genes, Reporter ; Genetic Predisposition to Disease ; HEK293 Cells ; Humans ; Luciferases/metabolism ; Male ; Mice ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Transcription Factors/metabolism ; Transcription, Genetic ; Young Adult
Czasopismo naukowe
Tytuł :
Accelerated evolution at chaperone promoters among Antarctic notothenioid fishes.
Autorzy :
Bogan SN; Department of Biology, Sonoma State University, Rohnert Park, CA, 94928, USA. .; Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, CA, 93106, USA. .
Place SP; Department of Biology, Sonoma State University, Rohnert Park, CA, 94928, USA.
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Źródło :
BMC evolutionary biology [BMC Evol Biol] 2019 Nov 06; Vol. 19 (1), pp. 205. Date of Electronic Publication: 2019 Nov 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Evolution, Molecular*
Promoter Regions, Genetic*
Fish Proteins/*genetics
Molecular Chaperones/*genetics
Perciformes/*genetics
Perciformes/*physiology
Adaptation, Physiological ; Animals ; Antarctic Regions ; Gene Expression Regulation ; Heat-Shock Response ; Phylogeny
Czasopismo naukowe
Tytuł :
A method for cost-effective and rapid characterization of engineered T7-based transcription factors by cell-free protein synthesis reveals insights into the regulation of T7 RNA polymerase-driven expression.
Autorzy :
McManus JB; Army Research Laboratory - West Campus, California Institute of Technology, 1200 East California Blvd, Pasadena, CA, 91125, USA.
Emanuel PA; US Army Combat Capabilities Development Command Chemical Biological Center, 8198 Blackhawk Rd, APG, MD, 21010, USA.
Murray RM; California Institute of Technology, Biology and Biological Engineering, 1200 East California Blvd, Pasadena, CA, 91125, USA.
Lux MW; US Army Combat Capabilities Development Command Chemical Biological Center, 8198 Blackhawk Rd, APG, MD, 21010, USA. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2019 Oct 15; Vol. 674, pp. 108045. Date of Electronic Publication: 2019 Jul 19.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Promoter Regions, Genetic*
Bacteriophage T7/*enzymology
DNA-Directed RNA Polymerases/*metabolism
Genetic Engineering/*methods
Repressor Proteins/*metabolism
Viral Proteins/*metabolism
Acoustics ; DNA-Directed RNA Polymerases/genetics ; Escherichia coli/genetics ; Gene Regulatory Networks ; Green Fluorescent Proteins/analysis ; Green Fluorescent Proteins/genetics ; Operator Regions, Genetic ; Polymerase Chain Reaction ; Transcription Initiation, Genetic ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters.
Autorzy :
Endres T; Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Solvie D; Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Heidelberger JB; Institute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany.
Andrioletti V; Internal Medicine VIII-Clinical Tumor Biology, University of Tübingen, Otfried-Müller-Straße 14, 72076 Tübingen, Germany.
Baluapuri A; Cancer Systems Biology Group, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Ade CP; Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Muhar M; Research Institute of Molecular Pathology, Campus Vienna Biocenter 1, 1030 Vienna, Austria.
Eilers U; Core Unit High-Content Microscopy, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Vos SM; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany; Massachusetts Institute of Technology, Department of Biology, 31 Ames Street, Cambridge, MA 02139, USA.
Cramer P; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Zuber J; Research Institute of Molecular Pathology, Campus Vienna Biocenter 1, 1030 Vienna, Austria.
Beli P; Institute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany.
Popov N; Internal Medicine VIII-Clinical Tumor Biology, University of Tübingen, Otfried-Müller-Straße 14, 72076 Tübingen, Germany.
Wolf E; Cancer Systems Biology Group, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Gallant P; Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Eilers M; Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, 97074 Würzburg, Germany. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 18; Vol. 81 (4), pp. 830-844.e13. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Repair*
Promoter Regions, Genetic*
Transcription Elongation, Genetic*
Proto-Oncogene Proteins c-myc/*metabolism
ATPases Associated with Diverse Cellular Activities/genetics ; ATPases Associated with Diverse Cellular Activities/metabolism ; Cell Line, Tumor ; Histones/genetics ; Histones/metabolism ; Humans ; Proto-Oncogene Proteins c-myc/genetics ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
Differential promoter methylation and G-712A polymorphism of brain-derived neurotrophic factor in post-traumatic stress disorder patients of Li and Han populations in Hainan province.
Autorzy :
Guo J; Department of Hepatobiliary Surgery, Central South University Xiangya School of Medical Affiliated Haikou Hospital, Haikou 570208, Hainan, PR China.
Yang Y; Department of Hepatobiliary Surgery, Central South University Xiangya School of Medical Affiliated Haikou Hospital, Haikou 570208, Hainan, PR China.
Jiang X; Psychological Research Center, Hainan General Hospital, Haikou 570311, Hainan, PR China.
Guo M; Psychological Research Center, Hainan General Hospital, Haikou 570311, Hainan, PR China. Electronic address: .
Li X; The Third People's Hospital of Hubei Province, Wuhan 430032, Hubei, PR China.
Huang P; University of South China, Hengyang 421001, Hunan, PR China.
Liu Z; Psychological Research Center, Hainan General Hospital, Haikou 570311, Hainan, PR China.
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Źródło :
Gene [Gene] 2021 Feb 15; Vol. 769, pp. 145192. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic*
Brain-Derived Neurotrophic Factor/*genetics
Stress Disorders, Post-Traumatic/*genetics
Adolescent ; Adult ; Asian Continental Ancestry Group/genetics ; Brain-Derived Neurotrophic Factor/blood ; Case-Control Studies ; China ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Minority Groups ; Regression Analysis ; Stress Disorders, Post-Traumatic/ethnology ; Surveys and Questionnaires ; Young Adult
Czasopismo naukowe
Tytuł :
A Transcription Regulatory Sequence in the 5' Untranslated Region of SARS-CoV-2 Is Vital for Virus Replication with an Altered Evolutionary Pattern against Human Inhibitory MicroRNAs.
Autorzy :
Mohammadi-Dehcheshmeh M; La Trobe Genomics Research Platform, School of Life Sciences, College of Science, Health and Engineering, La Trobe University, Melbourne, VIC 3086, Australia.; School of Animal and Veterinary Sciences, The University of Adelaide, Adelaide, SA 5371, Australia.
Moghbeli SM; Department of Animal Science, College of Agricultural and Life Sciences, University of Wisconsin, Madison, WI 1675, USA.
Rahimirad S; Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran 1497716316, Iran.
Alanazi IO; National Center for Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 6086, Saudi Arabia.
Shehri ZSA; Department of Medical Laboratories, College of Applied Medical Sciences, Shaqra University, KSA, Al dawadmi 1678, Saudi Arabia.
Ebrahimie E; La Trobe Genomics Research Platform, School of Life Sciences, College of Science, Health and Engineering, La Trobe University, Melbourne, VIC 3086, Australia.; School of Animal and Veterinary Sciences, The University of Adelaide, Adelaide, SA 5371, Australia.; School of BioSciences, The University of Melbourne, Melbourne, VIC 3052, Australia.
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Źródło :
Cells [Cells] 2021 Feb 04; Vol. 10 (2). Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
5' Untranslated Regions*
Virus Replication*
COVID-19/*virology
MicroRNAs/*genetics
SARS-CoV-2/*genetics
Animals ; Computational Biology ; Evolution, Molecular ; Genome, Viral ; Humans ; MicroRNAs/pharmacology ; Nucleic Acid Conformation ; RNA, Plant/pharmacology ; SARS-CoV-2/physiology
Czasopismo naukowe
Tytuł :
Self-organizing maps with variable neighborhoods facilitate learning of chromatin accessibility signal shapes associated with regulatory elements.
Autorzy :
Eicher T; Department of Biomedical Informatics, The Ohio State University College of Medicine, 370 W. 9th Avenue, Columbus, OH, 43210, USA.; Department of Computer Science and Engineering, The Ohio State University College of Engineering, 2015 Neil Avenue, Columbus, OH, 43210, USA.; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Dr., Rockville, MD, 20892, USA.
Chan J; Department of Biomedical Informatics, The Ohio State University College of Medicine, 370 W. 9th Avenue, Columbus, OH, 43210, USA.
Luu H; Department of Biomedical Informatics, The Ohio State University College of Medicine, 370 W. 9th Avenue, Columbus, OH, 43210, USA.
Machiraju R; Department of Biomedical Informatics, The Ohio State University College of Medicine, 370 W. 9th Avenue, Columbus, OH, 43210, USA. .; Department of Computer Science and Engineering, The Ohio State University College of Engineering, 2015 Neil Avenue, Columbus, OH, 43210, USA. .; Department of Pathology, The Ohio State University College of Medicine, 1645 Neil Ave, Columbus, OH, 43210, USA. .; Translational Data Analytics Institute, The Ohio State University, 1760 Neil Ave., Columbus, OH, 43210, USA. .
Mathé EA; Department of Biomedical Informatics, The Ohio State University College of Medicine, 370 W. 9th Avenue, Columbus, OH, 43210, USA. .; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Dr., Rockville, MD, 20892, USA. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Jan 30; Vol. 22 (1), pp. 35. Date of Electronic Publication: 2021 Jan 30.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatin*/genetics
Enhancer Elements, Genetic*
Promoter Regions, Genetic*
Adult ; Algorithms ; Child, Preschool ; HeLa Cells ; Humans ; Young Adult
Czasopismo naukowe
Tytuł :
A 1232 bp upstream sequence of glutamine synthetase 1b from Eichhornia crassipes is a root-preferential promoter sequence.
Autorzy :
Zhong Y; Bioengineering Department, Biological and Pharmaceutical College, Guangdong University of Technology, Guangzhou, Guangdong, P.R. China, 510006.
Lu X; Bioengineering Department, Biological and Pharmaceutical College, Guangdong University of Technology, Guangzhou, Guangdong, P.R. China, 510006.
Deng Z; Bioengineering Department, Biological and Pharmaceutical College, Guangdong University of Technology, Guangzhou, Guangdong, P.R. China, 510006.
Lu Z; Bioengineering Department, Biological and Pharmaceutical College, Guangdong University of Technology, Guangzhou, Guangdong, P.R. China, 510006.
Fu M; Bioengineering Department, Biological and Pharmaceutical College, Guangdong University of Technology, Guangzhou, Guangdong, P.R. China, 510006. .
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Źródło :
BMC plant biology [BMC Plant Biol] 2021 Jan 29; Vol. 21 (1), pp. 66. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Promoter Regions, Genetic*
Eichhornia/*enzymology
Eichhornia/*genetics
Glutamate-Ammonia Ligase/*genetics
Plant Roots/*genetics
Base Sequence ; Cloning, Molecular ; DNA, Plant ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Plant ; Hymecromone/analogs & derivatives ; Hymecromone/metabolism ; Plant Roots/enzymology ; Plants, Genetically Modified ; Real-Time Polymerase Chain Reaction ; Tobacco/genetics
Czasopismo naukowe
Tytuł :
Expression and clinical significance of SYNE1 and MAGI2 gene promoter methylation in gastric cancer.
Autorzy :
Qu Y; Department of Oncology, the Second Hospital of Dalian Medical University.
Gao N; Department of Obstetrics and Gynecology, the First Hospital of Dalian Medical University, Dalian, Liaoning, P.R. China.
Wu T; Department of Oncology, the Second Hospital of Dalian Medical University.
Pokaż więcej
Źródło :
Medicine [Medicine (Baltimore)] 2021 Jan 29; Vol. 100 (4), pp. e23788.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
DNA Methylation*
Promoter Regions, Genetic*
Adaptor Proteins, Signal Transducing/*genetics
Cytoskeletal Proteins/*genetics
Guanylate Kinases/*genetics
Nerve Tissue Proteins/*genetics
Stomach Neoplasms/*genetics
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Progression-Free Survival ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/mortality
Czasopismo naukowe

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