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Tytuł :
[Immunohistochemical double staining of CK8/18 and MLH1 or PMS2 in detecting the expression of mismatch repair protein in solid tumors].
Autorzy :
Liu Y; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy,Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Guo YH; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy,Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Wu SL; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy,Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Yue YW; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy,Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Sun Y; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy,Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
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Źródło :
Zhonghua bing li xue za zhi = Chinese journal of pathology [Zhonghua Bing Li Xue Za Zhi] 2021 May 08; Vol. 50 (5), pp. 520-523.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*
Neoplasms*
DNA Repair Enzymes/genetics ; Humans ; Mismatch Repair Endonuclease PMS2/genetics ; Mismatch Repair Endonuclease PMS2/metabolism ; MutL Protein Homolog 1/genetics ; MutS Homolog 2 Protein/genetics ; MutS Homolog 2 Protein/metabolism ; Staining and Labeling
Czasopismo naukowe
Tytuł :
A Consensus Model of Homology-Directed Repair Initiated by CRISPR/Cas Activity.
Autorzy :
Bloh K; Gene Editing Institute, Helen F. Graham Cancer Center & Research Institute, ChristianaCare, 4701 Ogletown-Stanton Road, Newark, DE 19710, USA.; Department of Medical and Molecular Sciences, University of Delaware, Newark, DE 19710, USA.
Rivera-Torres N; Gene Editing Institute, Helen F. Graham Cancer Center & Research Institute, ChristianaCare, 4701 Ogletown-Stanton Road, Newark, DE 19710, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 07; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
CRISPR-Cas Systems*
Gene Editing*
Recombinational DNA Repair*
DNA Repair ; INDEL Mutation ; Models, Biological ; RNA, Guide
Czasopismo naukowe
Tytuł :
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance.
Autorzy :
Schep R; Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
Brinkman EK; Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
Leemans C; Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
Vergara X; Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Cell Biology, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
van der Weide RH; Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
Morris B; Division of Molecular Carcinogenesis, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Robotics Screening Center, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
van Schaik T; Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
Manzo SG; Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
Peric-Hupkes D; Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
van den Berg J; Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Cell Biology, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
Beijersbergen RL; Division of Molecular Carcinogenesis, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Robotics Screening Center, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
Medema RH; Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Cell Biology, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
van Steensel B; Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Department of Cell Biology, Erasmus University Medical Centre, 3015 CN, Rotterdam, the Netherlands. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 May 20; Vol. 81 (10), pp. 2216-2230.e10. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Repair*
CRISPR-Associated Protein 9/*metabolism
Chromatin/*metabolism
Base Sequence ; DNA End-Joining Repair ; Euchromatin/metabolism ; Gene Rearrangement ; Genome, Human ; Heterochromatin/metabolism ; Humans ; INDEL Mutation/genetics ; K562 Cells ; Kinetics ; Protein Binding ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
[Mismatch repair protein expression of colorectal cancer: a retrospective analysis of 3 428 cases].
Autorzy :
Liu Y; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Guo YH; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Luo Y; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Sun L; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Zhao S; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Shao B; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Zang FL; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Qiu ZQ; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Sun BC; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Sun Y; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
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Źródło :
Zhonghua bing li xue za zhi = Chinese journal of pathology [Zhonghua Bing Li Xue Za Zhi] 2021 Apr 08; Vol. 50 (4), pp. 369-375.
Typ publikacji :
Journal Article
MeSH Terms :
Colorectal Neoplasms*/genetics
DNA Mismatch Repair*/genetics
DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Humans ; Microsatellite Instability ; Middle Aged ; Mismatch Repair Endonuclease PMS2/genetics ; Mismatch Repair Endonuclease PMS2/metabolism ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; MutS Homolog 2 Protein/metabolism ; Retrospective Studies
Czasopismo naukowe
Tytuł :
DNA mismatch repair proteins: scientific update and practical guide.
Autorzy :
Bateman AC; Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK .
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Źródło :
Journal of clinical pathology [J Clin Pathol] 2021 Apr; Vol. 74 (4), pp. 264-268. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Mismatch Repair*
Mutation*
Adenoma/*genetics
Biomarkers, Tumor/*genetics
Carcinoma/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
DNA Repair Enzymes/*genetics
Adenoma/enzymology ; Adenoma/pathology ; Adenoma/therapy ; Biomarkers, Tumor/metabolism ; Biopsy ; Carcinoma/enzymology ; Carcinoma/pathology ; Carcinoma/therapy ; Colorectal Neoplasms, Hereditary Nonpolyposis/enzymology ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; Colorectal Neoplasms, Hereditary Nonpolyposis/therapy ; DNA Repair Enzymes/metabolism ; Genetic Predisposition to Disease ; Humans ; Phenotype
Czasopismo naukowe
Tytuł :
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.
Autorzy :
Guo G; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Gao M; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Gao X; Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Zhu B; Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Huang J; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Tu X; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Kim W; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Zhao F; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Zhou Q; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Zhu S; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Wu Z; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Yan Y; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Zhang Y; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Zeng X; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Zhu Q; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Yin P; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Luo K; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Sun J; Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Deng M; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. .; Department of Oncology, Mayo Clinic, Rochester, MN, USA. .
Lou Z; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. .; Department of Oncology, Mayo Clinic, Rochester, MN, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 12; Vol. 12 (1), pp. 2187. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Repair*/radiation effects
DEAD Box Protein 58/*metabolism
DNA-Binding Proteins/*metabolism
Receptors, Immunologic/*metabolism
Signal Transduction/*immunology
A549 Cells ; Animals ; DNA Breaks, Double-Stranded/radiation effects ; DNA End-Joining Repair/radiation effects ; Dose-Response Relationship, Radiation ; Genome, Human ; HEK293 Cells ; Humans ; Mice ; Radiation, Ionizing ; Retroviridae/metabolism ; Virus Replication/radiation effects
Czasopismo naukowe
Tytuł :
PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.
Autorzy :
Morozko EL; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Smith-Geater C; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.
Monteys AM; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Pradhan S; Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.
Lim RG; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Langfelder P; Department of Human Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA 90095.
Kachemov M; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Hill A; Incisive Genetics Inc., Vancouver, BC, Canada V6A 0H9.
Stocksdale JT; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Cullis PR; NanoMedicines Innovation Network, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Wu J; Department of Biological Chemistry, University of California, Irvine, CA 92697.
Ochaba J; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Miramontes R; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Chakraborty A; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555.
Hazra TK; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555.
Lau A; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.
St-Cyr S; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Orellana I; Sue and Bill Gross Stem Cell Institute, University of California, Irvine, CA 92697.
Kopan L; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.
Wang KQ; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.
Yeung S; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Leavitt BR; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
Reidling JC; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Yang XW; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095.
Steffan JS; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Davidson BL; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Sarkar PS; Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.; Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555.
Thompson LM; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697; .; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.; Department of Biological Chemistry, University of California, Irvine, CA 92697.; Sue and Bill Gross Stem Cell Institute, University of California, Irvine, CA 92697.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 26; Vol. 118 (4).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Repair*
Protein Processing, Post-Translational*
DNA/*genetics
DNA Repair Enzymes/*genetics
Huntingtin Protein/*genetics
Huntington Disease/*genetics
Phosphotransferases (Alcohol Group Acceptor)/*genetics
Protein Inhibitors of Activated STAT/*genetics
Small Ubiquitin-Related Modifier Proteins/*genetics
Animals ; Cell Differentiation ; DNA/metabolism ; DNA Damage ; DNA Repair Enzymes/metabolism ; Disease Models, Animal ; Female ; Humans ; Huntingtin Protein/metabolism ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/metabolism ; Neurons/pathology ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Pluripotent Stem Cells/metabolism ; Pluripotent Stem Cells/pathology ; Primary Cell Culture ; Protein Inhibitors of Activated STAT/antagonists & inhibitors ; Protein Inhibitors of Activated STAT/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Small Ubiquitin-Related Modifier Proteins/antagonists & inhibitors ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Sumoylation ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex.
Autorzy :
Hammel M; Molecular Biophysics & Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Rashid I; Departments of Internal Medicine, Molecular Genetics & Microbiology and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87131, USA.
Sverzhinsky A; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Québec, Canada.
Pourfarjam Y; Department of Chemistry, University of Cincinnati, 301 Clifton Ct, Cincinnati, OH 45221, USA.
Tsai MS; Molecular Biophysics & Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Ellenberger T; Department of Biochemistry, Washington University, St. Louis, MO, USA.
Pascal JM; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Québec, Canada.
Kim IK; Department of Chemistry, University of Cincinnati, 301 Clifton Ct, Cincinnati, OH 45221, USA.
Tainer JA; Departments of Cancer Biology and Molecular & Cellular Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
Tomkinson AE; Departments of Internal Medicine, Molecular Genetics & Microbiology and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87131, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 11; Vol. 49 (1), pp. 306-321.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
DNA Ligase ATP/*metabolism
X-ray Repair Cross Complementing Protein 1/*metabolism
Chromatography, Gel ; Crystallography, X-Ray ; DNA Ligase ATP/chemistry ; Dimerization ; Humans ; Microscopy, Electron ; Models, Molecular ; Multiprotein Complexes ; Mutation ; Mutation, Missense ; Negative Staining ; Point Mutation ; Protein Conformation ; Protein Domains ; Protein Interaction Mapping ; Recombinant Proteins/metabolism ; Scattering, Small Angle ; X-ray Repair Cross Complementing Protein 1/chemistry ; X-ray Repair Cross Complementing Protein 1/genetics
Czasopismo naukowe
Tytuł :
On the Origins of Homology Directed Repair in Mammalian Cells.
Autorzy :
Sansbury BM; Gene Editing Institute, Helen F. Graham Cancer Center & Research Institute, ChristianaCare, Newark, DE 19713, USA.
Kmiec EB; Gene Editing Institute, Helen F. Graham Cancer Center & Research Institute, ChristianaCare, Newark, DE 19713, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 25; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Editorial
MeSH Terms :
Gene Editing*
Mutation*
Recombinational DNA Repair*
DNA/*chemistry
CRISPR-Cas Systems ; Cell Cycle ; DNA Breaks, Double-Stranded ; DNA Repair ; DNA, Single-Stranded ; Escherichia coli ; Genetic Engineering ; Genome, Human ; Humans ; Mutagenesis ; Oligonucleotides ; Saccharomyces cerevisiae
Opinia redakcyjna
Tytuł :
The Winged Helix Domain of CSB Regulates RNAPII Occupancy at Promoter Proximal Pause Sites.
Autorzy :
Batenburg NL; Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Cui S; Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Walker JR; Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Schellhorn HE; Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Zhu XD; Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 25; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Repair*
Gene Expression Regulation*
Mutation*
DNA Helicases/*metabolism
DNA Repair Enzymes/*metabolism
Neoplasms/*genetics
Poly-ADP-Ribose Binding Proteins/*metabolism
RNA Polymerase II/*metabolism
Cell Line, Tumor ; Cell Survival ; Cisplatin/adverse effects ; Cisplatin/pharmacology ; DNA Damage/drug effects ; DNA Helicases/chemistry ; DNA Repair Enzymes/chemistry ; Humans ; Poly-ADP-Ribose Binding Proteins/chemistry ; Promoter Regions, Genetic ; Protein Binding ; Transcription Factors/metabolism ; Ubiquitin/metabolism
Czasopismo naukowe
Tytuł :
[MutL Protein from the Neisseria gonorrhoeae Mismatch Repair System: Interaction with ATP and DNA].
Autorzy :
Monakhova MV; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119991 Russia.; .
Milakina MA; Department of Chemistry, Moscow State University, Moscow, 119991 Russia.
Savitskaia VY; Department of Chemistry, Moscow State University, Moscow, 119991 Russia.
Romanova EA; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119991 Russia.
Rao DN; Department of Biochemistry, Indian Institute of Science, Bangalore, 560012 India.
Kubareva EA; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119991 Russia.
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Źródło :
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2021 Mar-Apr; Vol. 55 (2), pp. 289-304.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*/genetics
Escherichia coli Proteins*
Adenosine Triphosphate ; DNA/genetics ; DNA Repair ; MutL Proteins/genetics ; MutL Proteins/metabolism ; Neisseria gonorrhoeae/genetics
Czasopismo naukowe
Tytuł :
DNA base excision repair and nucleotide excision repair proteins in malignant salivary gland tumors.
Autorzy :
Felix FA; Postgraduate Program in Dental Science, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
da Silva LP; Health and Biotechnology Institute, Federal University of Amazonas, Manaus, AM, Brazil.
Lopes MLDS; Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Sobral APV; Oral Pathology, School of Dentistry, University of Pernambuco, Camaragibe, PE, Brazil.
Freitas RA; Postgraduate Program in Dental Science, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
de Souza LB; Postgraduate Program in Dental Science, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Barboza CAG; Postgraduate Program in Dental Science, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address: .
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Źródło :
Archives of oral biology [Arch Oral Biol] 2021 Jan; Vol. 121, pp. 104987. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Repair*
Salivary Gland Neoplasms*/genetics
DNA-Binding Proteins/*genetics
Adenocarcinoma ; Carcinoma, Acinar Cell ; Carcinoma, Adenoid Cystic ; Carcinoma, Mucoepidermoid ; DNA-(Apurinic or Apyrimidinic Site) Lyase ; Humans ; X-ray Repair Cross Complementing Protein 1
Czasopismo naukowe
Tytuł :
A meta-analysis of reversion mutations in BRCA genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistance.
Autorzy :
Tobalina L; Bioinformatics and Data Science, Oncology R&D, AstraZeneca, Cambridge, UK.
Armenia J; Bioinformatics and Data Science, Oncology R&D, AstraZeneca, Cambridge, UK.
Irving E; DDR Biology, Bioscience, Oncology R&D, AstraZeneca, Cambridge, UK.
O'Connor MJ; DDR Biology, Bioscience, Oncology R&D, AstraZeneca, Cambridge, UK.
Forment JV; DDR Biology, Bioscience, Oncology R&D, AstraZeneca, Cambridge, UK. Electronic address: .
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Źródło :
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2021 Jan; Vol. 32 (1), pp. 103-112. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
DNA End-Joining Repair*
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; DNA Repair/genetics ; Drug Resistance, Neoplasm/genetics ; Female ; Genes, BRCA2 ; Humans ; Male ; Mutation
Czasopismo naukowe
Tytuł :
The CD44high Subpopulation of Multifraction Irradiation-Surviving NSCLC Cells Exhibits Partial EMT-Program Activation and DNA Damage Response Depending on Their p53 Status.
Autorzy :
Pustovalova M; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.
Alhaddad L; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.
Blokhina T; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.; State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), 123098 Moscow, Russia.; Semenov Institute of Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russia.
Smetanina N; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.; State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), 123098 Moscow, Russia.
Chigasova A; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.; Emanuel Institute for Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia.
Chuprov-Netochin R; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.
Eremin P; FSBI 'National Medical Research Center for Rehabilitation and Balneology', Ministry of Health of Russia, 121099 Moscow, Russia.
Gilmutdinova I; FSBI 'National Medical Research Center for Rehabilitation and Balneology', Ministry of Health of Russia, 121099 Moscow, Russia.
Osipov AN; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.; State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), 123098 Moscow, Russia.; Semenov Institute of Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russia.
Leonov S; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.; Institute of Cell Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 27; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 27.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
DNA Breaks, Double-Stranded*
Radiation Tolerance*
Recombinational DNA Repair*
Carcinoma, Non-Small-Cell Lung/*radiotherapy
Lung Neoplasms/*radiotherapy
Tumor Suppressor Protein p53/*metabolism
A549 Cells ; Autophagy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/physiopathology ; Cell Line, Tumor ; Cell Movement ; DNA/metabolism ; DNA End-Joining Repair ; Epithelial-Mesenchymal Transition ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/physiopathology ; Rad51 Recombinase/metabolism ; X-Rays
Czasopismo naukowe
Tytuł :
Impact of polymorphism in DNA repair genes OGG1 and XRCC1 on seminal parameters and human male infertility.
Autorzy :
Jalilvand A; Infertility Treatment Center, ACECR, Kermanshah, Iran.
Karimi N; Infertility Treatment Center, ACECR, Kermanshah, Iran.
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Źródło :
Andrologia [Andrologia] 2021 Feb; Vol. 53 (1), pp. e13633. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Letter; Comment
MeSH Terms :
DNA Repair*/genetics
Infertility, Male*/genetics
Humans ; Male ; X-ray Repair Cross Complementing Protein 1/genetics
Opinia redakcyjna
Tytuł :
Yeast Rpn4 Links the Proteasome and DNA Repair via RAD52 Regulation.
Autorzy :
Spasskaya DS; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, 119991 Moscow, Russia.
Nadolinskaia NI; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Tutyaeva VV; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, 119991 Moscow, Russia.
Lysov YP; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Karpov VL; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Karpov DS; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, 119991 Moscow, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 30; Vol. 21 (21). Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Repair*
Gene Expression Regulation, Fungal*
DNA-Binding Proteins/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Rad52 DNA Repair and Recombination Protein/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Transcription Factors/*metabolism
CRISPR-Cas Systems ; DNA Damage ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/genetics ; Mutation ; Rad52 DNA Repair and Recombination Protein/antagonists & inhibitors ; Rad52 DNA Repair and Recombination Protein/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae Proteins/antagonists & inhibitors ; Saccharomyces cerevisiae Proteins/genetics ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Activated STAT3 Is a Novel Regulator of the XRCC1 Promoter and Selectively Increases XRCC1 Protein Levels in Triple Negative Breast Cancer.
Autorzy :
Wright G; Department of Physiology and Cell Biology, University of South Alabama College of Medicine, 307 N University Blvd, Mobile, AL 36688, USA.; Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36604-1405, USA.
Sonavane M; Department of Physiology and Cell Biology, University of South Alabama College of Medicine, 307 N University Blvd, Mobile, AL 36688, USA.; Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36604-1405, USA.
Gassman NR; Department of Physiology and Cell Biology, University of South Alabama College of Medicine, 307 N University Blvd, Mobile, AL 36688, USA.; Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36604-1405, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 22; Vol. 22 (11). Date of Electronic Publication: 2021 May 22.
Typ publikacji :
Journal Article
MeSH Terms :
Promoter Regions, Genetic/*genetics
STAT3 Transcription Factor/*genetics
Triple Negative Breast Neoplasms/*genetics
X-ray Repair Cross Complementing Protein 1/*genetics
Cell Line ; Cell Line, Tumor ; DNA Breaks, Single-Stranded ; DNA Damage/genetics ; DNA Repair/genetics ; DNA-Binding Proteins/genetics ; HEK293 Cells ; Humans ; Interleukin-6/genetics ; Phosphorylation/genetics ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
A PRISMA-compliant meta-analysis on association between X-ray repair cross complementing (XRCC1, XRCC2, and XRCC3) polymorphisms and oral cancer susceptibility.
Autorzy :
Mozaffari HR; Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
Rostamnia M; Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran.
Sharifi R; Department of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
Safaei M; Advanced Dental Sciences Research Center, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
Zavattaro E; Dermatology Unit, Department of Translational Medicine, University of Eastern Piedmont, Novara 28100, Italy.
Tadakamadla SK; School of Dentistry and Oral Health, Menzies Health Institute Queensland, Griffith University, Gold Coast 4214, Australia.
Imani MM; Department of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
Sadeghi M; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran. Electronic address: .
Golshah A; Department of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
Moradpoor H; Department of Prosthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
Rezaei F; Department of Oral and Maxillofacial Surgery, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
Omidpanah N; Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
Hatami M; Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
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Źródło :
Gene [Gene] 2021 May 20; Vol. 781, pp. 145524. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Meta-Analysis; Review
MeSH Terms :
DNA Repair*
DNA-Binding Proteins/*genetics
Mouth Neoplasms/*genetics
X-ray Repair Cross Complementing Protein 1/*genetics
Genetic Predisposition to Disease ; Humans ; Polymorphism, Genetic
Czasopismo naukowe
Tytuł :
Vitamin D changes expression of DNA repair genes in the patients with multiple sclerosis.
Autorzy :
Amirinejad R; Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Shirvani-Farsani Z; Department of Cell and Molecular Biology, Faculty of Biological Sciences and Technology, Shahid Beheshti University G.C., Tehran, Iran.
Naghavi Gargari B; Department of Basic Sciences, Faculty Nursing and Midwifery Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sahraian MA; MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Soltani B; Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Behmanesh M; Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: .
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Źródło :
Gene [Gene] 2021 May 20; Vol. 781, pp. 145488. Date of Electronic Publication: 2021 Feb 13.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
DNA Repair/*genetics
Gene Expression/*drug effects
Multiple Sclerosis/*genetics
Vitamin D/*pharmacology
Vitamins/*pharmacology
Adult ; Computer Simulation ; DNA Glycosylases/genetics ; DNA Repair/drug effects ; DNA Repair Enzymes/genetics ; Female ; Humans ; Male ; Multiple Sclerosis/drug therapy ; NF-E2-Related Factor 2/genetics ; Phosphoric Monoester Hydrolases/genetics ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Functional Roles of PARP2 in Assembling Protein-Protein Complexes Involved in Base Excision DNA Repair.
Autorzy :
Vasil'eva I; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Moor N; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Anarbaev R; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kutuzov M; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Lavrik O; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 28; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 28.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Repair/*physiology
Poly(ADP-ribose) Polymerases/*physiology
DNA/chemistry ; DNA Damage/physiology ; DNA Polymerase beta/genetics ; DNA Repair/genetics ; DNA-(Apurinic or Apyrimidinic Site) Lyase/genetics ; Humans ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly ADP Ribosylation/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Protein Interaction Maps ; X-ray Repair Cross Complementing Protein 1/metabolism
Czasopismo naukowe

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