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Wyszukujesz frazę ""reverse transcriptase"" wg kryterium: Temat


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Tytuł:
5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action.
Autorzy:
Corona A; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Meleddu R; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Delelis O; Laboratory of Biology and Applied Pharmacology (LBPA), Ecole Normale Supérieure (ENS) Cachan, Centre National de la Recherche Scientifique (CNRS), Cachan, France.
Subra F; Laboratory of Biology and Applied Pharmacology (LBPA), Ecole Normale Supérieure (ENS) Cachan, Centre National de la Recherche Scientifique (CNRS), Cachan, France.
Cottiglia F; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Esposito F; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Distinto S; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Maccioni E; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Tramontano E; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
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Źródło:
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Jun 23; Vol. 13, pp. 1193280. Date of Electronic Publication: 2023 Jun 23 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Reverse Transcriptase Inhibitors*/chemistry
Reverse Transcriptase Inhibitors*/pharmacology
HIV-1*
Structure-Activity Relationship ; Oxindoles ; HIV Reverse Transcriptase/chemistry ; HIV Reverse Transcriptase/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł:
Structure-directed linker optimization of novel HEPTs as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Autorzy:
Hao QQ; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China; Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Chen XM; Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Pannecouque C; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
De Clercq E; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Wang S; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China. Electronic address: .
Chen FE; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China; Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2023 Apr; Vol. 133, pp. 106413. Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-HIV Agents*/pharmacology
Anti-HIV Agents*/chemistry
Reverse Transcriptase Inhibitors*/pharmacology
Reverse Transcriptase Inhibitors*/chemistry
HIV Reverse Transcriptase ; Molecular Docking Simulation ; Structure-Activity Relationship ; Thymine
Czasopismo naukowe
Tytuł:
Recent advances on dual inhibitors targeting HIV reverse transcriptase associated polymerase and ribonuclease H.
Autorzy:
Kang JX; Department of Pharmacy, Armed Police Forces Hospital of Sichuan, 614000, Leshan, China.
Zhao GK; Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, 400038, Chongqing, China.
Yang XM; Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, 400038, Chongqing, China.
Huang MX; Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, 400038, Chongqing, China.
Hui WQ; Department of Pharmacy, Xi'an Fifth Hospital, Xian, 710082, Shaanxi, China.
Zeng R; Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, 400038, Chongqing, China.
Ouyang Q; Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, 400038, Chongqing, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Mar 15; Vol. 250, pp. 115196. Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:
Journal Article; Review
MeSH Terms:
HIV Reverse Transcriptase*
Anti-HIV Agents*/pharmacology
Humans ; Ribonuclease H ; Reverse Transcriptase Inhibitors/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Cis -Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase.
Autorzy:
Masuda T; Department of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Yushima, 1-5-45 Bunkyo-ku, Tokyo 113-8519, Japan.
Kotani O; Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Gakuen, 4-7-1, Musashimurayama-shi, Tokyo 208-0011, Japan.
Yokoyama M; Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Gakuen, 4-7-1, Musashimurayama-shi, Tokyo 208-0011, Japan.
Abe Y; Department of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Yushima, 1-5-45 Bunkyo-ku, Tokyo 113-8519, Japan.
Kawai G; Department of Life Science, Faculty of Advanced Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino-shi, Chiba 275-0016, Japan.
Sato H; Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Gakuen, 4-7-1, Musashimurayama-shi, Tokyo 208-0011, Japan.
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Źródło:
Viruses [Viruses] 2022 Dec 21; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Reverse Transcriptase*/genetics
HIV Reverse Transcriptase*/metabolism
HIV Integrase*/metabolism
Allosteric Regulation ; Reverse Transcriptase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł:
Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability.
Autorzy:
Zhao LM; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji, Jilin Province, 133002, China; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, China.
Wang S; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, China.
Pannecouque C; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B, 3000, Leuven, Belgium.
De Clercq E; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B, 3000, Leuven, Belgium.
Piao HR; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji, Jilin Province, 133002, China. Electronic address: .
Chen FE; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji, Jilin Province, 133002, China; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Oct 05; Vol. 240, pp. 114581. Date of Electronic Publication: 2022 Jun 30.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-HIV Agents*/chemistry
Reverse Transcriptase Inhibitors*/chemistry
Reverse Transcriptase Inhibitors*/pharmacology
Biological Availability ; Biphenyl Compounds ; HIV Reverse Transcriptase/metabolism ; Pyridones/chemistry ; Pyridones/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Internal RNA 2'-O-methylation on the HIV-1 genome impairs reverse transcription.
Autorzy:
Decombe A; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique, Aix-Marseille Université, Marseille 13288, France.
Peersen O; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA.
Sutto-Ortiz P; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique, Aix-Marseille Université, Marseille 13288, France.
Chamontin C; Institut de Recherche en Infectiologie de Montpellier (IRIM), Centre National de la Recherche Scientifique, Université de Montpellier, Montpellier 34090, France.
Piorkowski G; Unité des Virus Émergents (UVE: Aix-Marseille Univ-IRD 190-Inserm 1207), 13005 Marseille, France.
Canard B; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique, Aix-Marseille Université, Marseille 13288, France.
Nisole S; Institut de Recherche en Infectiologie de Montpellier (IRIM), Centre National de la Recherche Scientifique, Université de Montpellier, Montpellier 34090, France.
Decroly E; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique, Aix-Marseille Université, Marseille 13288, France.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2024 Feb 09; Vol. 52 (3), pp. 1359-1373.
Typ publikacji:
Journal Article
MeSH Terms:
HIV Reverse Transcriptase*/genetics
HIV Reverse Transcriptase*/metabolism
HIV-1*/genetics
HIV-1*/metabolism
RNA, Viral*/metabolism
Virus Replication*
RNA Processing, Post-Transcriptional*
Humans ; Methylation ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Nucleotides/metabolism ; Reverse Transcription
Czasopismo naukowe
Tytuł:
HIV-1 Reverse Transcriptase Expression in HPV16-Infected Epidermoid Carcinoma Cells Alters E6 Expression and Cellular Metabolism, and Induces a Hybrid Epithelial/Mesenchymal Cell Phenotype.
Autorzy:
Zhitkevich A; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, 119991 Moscow, Russia.
Bayurova E; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, 119991 Moscow, Russia.; Gamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.
Avdoshina D; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, 119991 Moscow, Russia.
Zakirova N; Centre for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, 119991 Moscow, Russia.
Frolova G; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, 119991 Moscow, Russia.
Jansons J; Biomedical Research and Study Centers, LV-1067 Riga, Latvia.; Institute of Microbiology and Virology, Riga Stradins University, LV-1007 Riga, Latvia.
Chowdhury S; Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, CA 94143, USA.
Ivanov A; Gamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.; Centre for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, 119991 Moscow, Russia.
Gordeychuk I; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, 119991 Moscow, Russia.; Gamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.
Palefsky JM; Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, CA 94143, USA.
Isaguliants M; Institute of Microbiology and Virology, Riga Stradins University, LV-1007 Riga, Latvia.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden.
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Źródło:
Viruses [Viruses] 2024 Jan 26; Vol. 16 (2). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:
Journal Article
MeSH Terms:
Oncogene Proteins, Viral*/genetics
Oncogene Proteins, Viral*/metabolism
Carcinoma, Squamous Cell*
Uterine Cervical Neoplasms*
HIV Reverse Transcriptase*
Animals ; Mice ; Humans ; Female ; Papillomavirus E7 Proteins/genetics ; Human papillomavirus 16/physiology ; Mice, Nude ; Repressor Proteins/genetics ; Epithelial Cells/metabolism ; Phenotype
Czasopismo naukowe
Tytuł:
Polypyridyl ruthenium complexes as bifunctional TAR RNA binders and HIV-1 reverse transcriptase inhibitors.
Autorzy:
Wang MF; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
Li Y; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
Bi XD; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
Guo YX; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
Liu M; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
Zhang H; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
Gao F; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China. Electronic address: .
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Źródło:
Journal of inorganic biochemistry [J Inorg Biochem] 2022 Sep; Vol. 234, pp. 111880. Date of Electronic Publication: 2022 Jun 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV-1*/drug effects
Reverse Transcriptase Inhibitors*/pharmacology
Ruthenium*/chemistry
Ruthenium*/pharmacology
HIV Reverse Transcriptase/metabolism ; Humans ; RNA ; SARS-CoV-2
Czasopismo naukowe
Tytuł:
Scorpion-Shaped Zinc Porphyrins as Tetrafunctional TAR RNA Predators and HIV-1 Reverse Transcriptase Inhibitors.
Autorzy:
Yang R; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.
Bi XD; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.
Li Y; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.
Liu M; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.
Hu MQ; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.
Zhao LM; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.
Zhang H; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.
Gao F; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.
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Źródło:
Inorganic chemistry [Inorg Chem] 2022 Jul 18; Vol. 61 (28), pp. 10774-10780. Date of Electronic Publication: 2022 Jul 07.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*
HIV-1*
Metalloporphyrins*/pharmacology
Reverse Transcriptase Inhibitors*/chemistry
Reverse Transcriptase Inhibitors*/pharmacology
HIV Reverse Transcriptase/antagonists & inhibitors ; Humans ; RNA, Viral ; SARS-CoV-2
Czasopismo naukowe
Tytuł:
Novel RNase H Inhibitors Blocking RNA-directed Strand Displacement DNA Synthesis by HIV-1 Reverse Transcriptase.
Autorzy:
Martín-Alonso S; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China.
Martínez Del Río J; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
Luczkowiak J; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
Frutos-Beltrán E; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
Zhang L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China.
Cheng X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China.
Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China. Electronic address: .
Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China. Electronic address: .
Menéndez-Arias L; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, 28049 Madrid, Spain. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2022 Apr 15; Vol. 434 (7), pp. 167507. Date of Electronic Publication: 2022 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
DNA, Viral*/biosynthesis
HIV Reverse Transcriptase*/genetics
HIV Reverse Transcriptase*/metabolism
Ribonuclease H, Human Immunodeficiency Virus*/antagonists & inhibitors
Ribonuclease H, Human Immunodeficiency Virus*/metabolism
Anti-Retroviral Agents/chemistry ; Anti-Retroviral Agents/pharmacology ; Drug Development ; Humans ; Reverse Transcriptase Inhibitors/pharmacology ; Tropolone/analogs & derivatives ; Tropolone/pharmacology
Czasopismo naukowe
Tytuł:
Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies.
Autorzy:
Singh AK; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.; Department of Microbiology, Immunology and Transplantation, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Das K; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.; Department of Microbiology, Immunology and Transplantation, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
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Źródło:
Viruses [Viruses] 2022 May 11; Vol. 14 (5). Date of Electronic Publication: 2022 May 11.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Viral*
HIV Infections*
HIV-1*/drug effects
Reverse Transcriptase Inhibitors*/pharmacology
Reverse Transcriptase Inhibitors*/therapeutic use
HIV Reverse Transcriptase/genetics ; Humans
Czasopismo naukowe
Tytuł:
Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase.
Autorzy:
Kirby TW; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC 27709, USA.
Gabel SA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC 27709, USA.
DeRose EF; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC 27709, USA.
Perera L; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC 27709, USA.
Krahn JM; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC 27709, USA.
Pedersen LC; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC 27709, USA.
London RE; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC 27709, USA.
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Źródło:
Biomolecules [Biomolecules] 2023 Nov 01; Vol. 13 (11). Date of Electronic Publication: 2023 Nov 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms:
HIV Reverse Transcriptase*/chemistry
Ligands ; Dimerization ; Magnetic Resonance Spectroscopy
Czasopismo naukowe
Tytuł:
Repurposing nucleoside reverse transcriptase inhibitors (NRTIs) to slow aging.
Autorzy:
Brochard T; Laboratory Genetic Metabolic Diseases, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
McIntyre RL; Laboratory Genetic Metabolic Diseases, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
Houtkooper RH; Laboratory Genetic Metabolic Diseases, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.
Seluanov A; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA.
Gorbunova V; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA.
Janssens GE; Laboratory Genetic Metabolic Diseases, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: .
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Źródło:
Ageing research reviews [Ageing Res Rev] 2023 Dec; Vol. 92, pp. 102132. Date of Electronic Publication: 2023 Nov 19.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Reverse Transcriptase Inhibitors*/adverse effects
HIV Infections*/drug therapy
Humans ; Nucleosides/pharmacology ; Nucleosides/therapeutic use ; Drug Repositioning ; Aging
Czasopismo naukowe
Tytuł:
Effect of Food on the Pharmacokinetics of Tenofovir Amibufenamide: A Phase I, Randomized, Open-Label, Two-Period Crossover Trial in Healthy Adult Subjects.
Autorzy:
Liu J; Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou, Zhejiang Province, People's Republic of China.
Wu M; Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou, Zhejiang Province, People's Republic of China.
Kai J; Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou, Zhejiang Province, People's Republic of China.
Lin M; Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou, Zhejiang Province, People's Republic of China.
Zheng Y; Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou, Zhejiang Province, People's Republic of China.
Jiang Y; Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou, Zhejiang Province, People's Republic of China.
Huang Q; Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou, Zhejiang Province, People's Republic of China.
Zhai Y; Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou, Zhejiang Province, People's Republic of China.
Qiu Y; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou, Zhejiang Province, People's Republic of China.; State Key Laboratory for Diagnosis and Treatment of Infectious Disease, the First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.
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Źródło:
Drug design, development and therapy [Drug Des Devel Ther] 2023 Oct 09; Vol. 17, pp. 3061-3072. Date of Electronic Publication: 2023 Oct 09 (Print Publication: 2023).
Typ publikacji:
Randomized Controlled Trial; Clinical Trial, Phase I; Journal Article
MeSH Terms:
Reverse Transcriptase Inhibitors*
Fasting*
Humans ; Adult ; Cross-Over Studies ; Healthy Volunteers ; Area Under Curve ; Therapeutic Equivalency ; Tenofovir ; Tablets
Czasopismo naukowe
Tytuł:
Charge Engineering of the Nucleic Acid Binding Cleft of a Thermostable HIV-1 Reverse Transcriptase Reveals Key Interactions and a Novel Mechanism of RNase H Inactivation.
Autorzy:
Martínez Del Río J; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, Madrid, Spain.
López-Carrobles N; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, Madrid, Spain.
Mendieta-Moreno JI; Department of Theoretical Condensed Matter Physics, Universidad Autónoma de Madrid, Spain.
Herrera-Chacón Ó; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, Madrid, Spain.
Sánchez-Ibáñez A; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, Madrid, Spain.
Mendieta J; Department of Biotechnology, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain.
Menéndez-Arias L; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, Madrid, Spain. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2023 Sep 15; Vol. 435 (18), pp. 168219. Date of Electronic Publication: 2023 Aug 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Reverse Transcriptase*/chemistry
HIV Reverse Transcriptase*/genetics
HIV Reverse Transcriptase*/metabolism
Ribonuclease H*/chemistry
Ribonuclease H*/genetics
Ribonuclease H*/metabolism
Humans ; DNA, Complementary ; Protein Domains ; RNA/metabolism ; Amino Acid Substitution
Czasopismo naukowe
Tytuł:
Nucleoside Analog Reverse-Transcriptase Inhibitors in Membrane Environment: Molecular Dynamics Simulations.
Autorzy:
Stachowicz-Kuśnierz A; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Korchowiec B; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Korchowiec J; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Aug 27; Vol. 28 (17). Date of Electronic Publication: 2023 Aug 27.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Dynamics Simulation*
Reverse Transcriptase Inhibitors*
Stavudine ; Phospholipids ; DNA-Directed RNA Polymerases
Czasopismo naukowe
Tytuł:
Development and Implementation of a Quadruple RT-qPCR Method for the Identification of Porcine Reproductive and Respiratory Syndrome Virus Strains.
Autorzy:
Ruan S; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan 430070, China.
Ren W; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan 430070, China.
Yu B; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan 430070, China.
Yu X; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan 430070, China.
Wu H; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan 430070, China.
Li W; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan 430070, China.
Jiang Y; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan 430070, China.
He Q; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan 430070, China.
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Źródło:
Viruses [Viruses] 2023 Sep 18; Vol. 15 (9). Date of Electronic Publication: 2023 Sep 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Porcine Reproductive and Respiratory Syndrome*/diagnosis
Porcine respiratory and reproductive syndrome virus*/genetics
Reverse Transcriptase Polymerase Chain Reaction*/veterinary
Animals ; Female ; Pregnancy ; China/epidemiology ; Sus scrofa ; Swine
Czasopismo naukowe
Tytuł:
Dolutegravir-associated resistance mutations after first-line treatment failure in Brazil.
Autorzy:
Diaz RS; Federal University of São Paulo, São Paulo, Brazil. .
Hunter JR; Federal University of São Paulo, São Paulo, Brazil.
Camargo M; Federal University of São Paulo, São Paulo, Brazil.
Dias D; Federal University of São Paulo, São Paulo, Brazil.
Galinskas J; Federal University of São Paulo, São Paulo, Brazil.
Nassar I; Federal University of São Paulo, São Paulo, Brazil.
de Lima IB; Federal University of São Paulo, São Paulo, Brazil.
Caldeira DB; Federal University of São Paulo, São Paulo, Brazil.
Sucupira MC; Federal University of São Paulo, São Paulo, Brazil.
Schechter M; Federal University of São Paulo, São Paulo, Brazil.; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
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Źródło:
BMC infectious diseases [BMC Infect Dis] 2023 May 24; Vol. 23 (1), pp. 347. Date of Electronic Publication: 2023 May 24.
Typ publikacji:
Journal Article
MeSH Terms:
Reverse Transcriptase Inhibitors*/pharmacology
Reverse Transcriptase Inhibitors*/therapeutic use
HIV Infections*/drug therapy
Humans ; Brazil ; Lamivudine/pharmacology ; Lamivudine/therapeutic use ; Mutation ; Anti-Retroviral Agents ; Tenofovir ; Treatment Failure
Czasopismo naukowe
Tytuł:
Synthesis and anti-HIV activities of phorbol derivatives.
Autorzy:
Huang X; College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
Tang C; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Huang X; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China.
Yang Y; College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
Li Q; College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
Ma M; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Zhao L; College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
Yang L; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Cui Y; College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
Zhang Z; College of Pharmaceutical Science, Soochow University, Suzhou 215123, China. Electronic address: z_.
Zheng Y; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China. Electronic address: .
Zhang J; College of Pharmaceutical Science, Soochow University, Suzhou 215123, China. Electronic address: jian.
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Źródło:
Chinese journal of natural medicines [Chin J Nat Med] 2024 Feb; Vol. 22 (2), pp. 146-160.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-HIV Agents*/pharmacology
Anti-HIV Agents*/chemistry
Phorbols*/chemistry
Phorbols*/pharmacology
Molecular Docking Simulation ; Phorbol Esters/pharmacology ; HIV Reverse Transcriptase/chemistry ; HIV Reverse Transcriptase/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Selected Milestones in Antiviral Drug Development.
Autorzy:
De Clercq E; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
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Źródło:
Viruses [Viruses] 2024 Jan 23; Vol. 16 (2). Date of Electronic Publication: 2024 Jan 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Anti-HIV Agents*/therapeutic use
Virus Diseases*/drug therapy
HIV Infections*/drug therapy
Humans ; Reverse Transcriptase Inhibitors/pharmacology ; Drug Development ; HIV Reverse Transcriptase
Czasopismo naukowe

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