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Tytuł :
Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma.
Autorzy :
Federico C; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Alhallak K; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Sun J; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Duncan K; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Azab F; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Sudlow GP; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
de la Puente P; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Muz B; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Kapoor V; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Zhang L; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Yuan F; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, USA.
Markovic M; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, USA.
Kotsybar J; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, USA.
Wasden K; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Guenthner N; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Gurley S; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
King J; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Kohnen D; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Salama NN; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, USA.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Thotala D; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Hallahan DE; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Vij R; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
DiPersio JF; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Achilefu S; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Azab AK; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA. .; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 27; Vol. 11 (1), pp. 6037. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Tumor Microenvironment*/drug effects
Bortezomib/*therapeutic use
Multiple Myeloma/*drug therapy
Multiple Myeloma/*pathology
Nanoparticles/*chemistry
Protein Kinase Inhibitors/*therapeutic use
rho-Associated Kinases/*antagonists & inhibitors
Amides/pharmacology ; Amides/therapeutic use ; Animals ; Apoptosis/drug effects ; Bortezomib/pharmacology ; Cell Adhesion/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Disease Progression ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Liposomes ; Membrane Glycoproteins/metabolism ; Mice ; P-Selectin/metabolism ; Protein Binding ; Protein Kinase Inhibitors/pharmacology ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Signal Transduction/drug effects ; Tumor Burden ; rho-Associated Kinases/metabolism ; src-Family Kinases/metabolism
Czasopismo naukowe
Tytuł :
Baicalein suppresses vasculogenic mimicry through inhibiting RhoA/ROCK expression in lung cancer A549 cell line.
Autorzy :
Zhang Z; Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China, and.
Nong L; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
Chen M; Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China, and.
Gu X; Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China, and.
Zhao W; Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China, and.
Liu M; Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China, and.
Cheng W; Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China, and.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2020 Sep 08; Vol. 52 (9), pp. 1007-1015.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung*/blood supply
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/enzymology
Lung Neoplasms*/blood supply
Lung Neoplasms*/drug therapy
Lung Neoplasms*/enzymology
Lung Neoplasms*/genetics
Neovascularization, Pathologic*/drug therapy
Neovascularization, Pathologic*/epidemiology
Neovascularization, Pathologic*/genetics
Flavanones/*pharmacology
Neoplasm Proteins/*metabolism
rho-Associated Kinases/*metabolism
rhoA GTP-Binding Protein/*metabolism
A549 Cells ; Humans ; Neoplasm Proteins/genetics ; rho-Associated Kinases/genetics ; rhoA GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
Rho Kinase Inhibition by Fasudil Attenuates Adriamycin-Induced Chronic Heart Injury.
Autorzy :
Yan Y; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, China.; Department of Cardiology, Jiangyin People's Hospital, No. 163, Shoushan Road, Jiangyin, China.
Xiang C; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, China.
Yang Z; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, China.
Miao D; Bone and Stem Cell Research Center, Nanjing Medical University, No. 101, Longmian Avenue, Nanjing, China.
Zhang D; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, China. .
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Źródło :
Cardiovascular toxicology [Cardiovasc Toxicol] 2020 Aug; Vol. 20 (4), pp. 351-360.
Typ publikacji :
Journal Article
MeSH Terms :
Doxorubicin*
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives
Antioxidants/*pharmacology
Heart Diseases/*prevention & control
Myocytes, Cardiac/*drug effects
Protein Kinase Inhibitors/*pharmacology
rho-Associated Kinases/*antagonists & inhibitors
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology ; Animals ; Apoptosis/drug effects ; Biomarkers/blood ; Cardiotoxicity ; Chronic Disease ; Disease Models, Animal ; Heart Diseases/chemically induced ; Heart Diseases/metabolism ; Heart Diseases/pathology ; Male ; Mice, Inbred C57BL ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Oxidative Stress/drug effects ; Signal Transduction ; Ventricular Function, Left/drug effects ; rho-Associated Kinases/metabolism ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Enhanced peripheral blood miR-324-5p is associated with the risk of metabolic syndrome by suppressing ROCK1.
Autorzy :
Guo J; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China.
Yang C; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China; Clinical Laboratory, China Japan Friendship Hospital, PR China.
Lin Y; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China.
Hu G; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China.
Wei J; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China.
Zhang X; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China.
Chen X; Department of Geriatrics Cardiovascular Medicine, FuWai Hospital, Chinese Academy of Medical Sciences, No. 12, LangShan Road, ShenZhen City, Guangdong Province 518112, PR China. Electronic address: .
Li J; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2020 Aug; Vol. 1865 (8), pp. 158727. Date of Electronic Publication: 2020 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Metabolic Syndrome/*metabolism
MicroRNAs/*metabolism
rho-Associated Kinases/*metabolism
Animals ; Glucose/metabolism ; Humans ; Lipid Metabolism ; Metabolic Syndrome/genetics ; Mice ; Mice, Inbred C57BL ; MicroRNAs/blood ; MicroRNAs/genetics ; Risk Factors ; rho-Associated Kinases/deficiency
Czasopismo naukowe
Tytuł :
The influence of hypoxia and energy depletion on the response of endothelial cells to the vascular disrupting agent combretastatin A-4-phosphate.
Autorzy :
Holmes T; Tumour Microcirculation Group, Department of Oncology and Metabolism, University of Sheffield, School of Medicine, Beech Hill Road, Sheffield, S10 2RX, United Kingdom.
Brown AW; Department of Chemistry, University of Sheffield, Dainton Building, Brook Hill, Sheffield, S3 7HF, United Kingdom.
Suggitt M; Tumour Microcirculation Group, Department of Oncology and Metabolism, University of Sheffield, School of Medicine, Beech Hill Road, Sheffield, S10 2RX, United Kingdom.
Shaw LA; Tumour Microcirculation Group, Department of Oncology and Metabolism, University of Sheffield, School of Medicine, Beech Hill Road, Sheffield, S10 2RX, United Kingdom.
Simpson L; Tumour Microcirculation Group, Department of Oncology and Metabolism, University of Sheffield, School of Medicine, Beech Hill Road, Sheffield, S10 2RX, United Kingdom.
Harrity JPA; Department of Chemistry, University of Sheffield, Dainton Building, Brook Hill, Sheffield, S3 7HF, United Kingdom.
Tozer GM; Tumour Microcirculation Group, Department of Oncology and Metabolism, University of Sheffield, School of Medicine, Beech Hill Road, Sheffield, S10 2RX, United Kingdom.
Kanthou C; Tumour Microcirculation Group, Department of Oncology and Metabolism, University of Sheffield, School of Medicine, Beech Hill Road, Sheffield, S10 2RX, United Kingdom. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jun 18; Vol. 10 (1), pp. 9926. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelium, Vascular/*pathology
Hypoxia/*physiopathology
Neovascularization, Pathologic/*pathology
Stilbenes/*pharmacology
rho-Associated Kinases/*antagonists & inhibitors
rhoA GTP-Binding Protein/*antagonists & inhibitors
Actins/metabolism ; Antineoplastic Agents, Phytogenic/pharmacology ; Cell Membrane Permeability ; Endothelium, Vascular/drug effects ; Human Umbilical Vein Endothelial Cells ; Humans ; Neovascularization, Pathologic/chemically induced ; Signal Transduction ; rho-Associated Kinases/genetics ; rho-Associated Kinases/metabolism ; rhoA GTP-Binding Protein/genetics ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Assembly of a persistent apical actin network by the formin Frl/Fmnl tunes epithelial cell deformability.
Autorzy :
Dehapiot B; Aix Marseille Université, CNRS, IBDM-UMR7288, Turing Center for Living Systems, Marseille, France.
Clément R; Aix Marseille Université, CNRS, IBDM-UMR7288, Turing Center for Living Systems, Marseille, France.
Alégot H; Aix Marseille Université, CNRS, IBDM-UMR7288, Turing Center for Living Systems, Marseille, France.
Gazsó-Gerhát G; Institute of Genetics, Biological Research Centre, HAS, Szeged, Hungary.; Doctoral School of Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Philippe JM; Aix Marseille Université, CNRS, IBDM-UMR7288, Turing Center for Living Systems, Marseille, France.
Lecuit T; Aix Marseille Université, CNRS, IBDM-UMR7288, Turing Center for Living Systems, Marseille, France. .; Collège de France, Paris, France. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2020 Jul; Vol. 22 (7), pp. 791-802. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Actin Cytoskeleton/*physiology
Drosophila melanogaster/*metabolism
Epithelial Cells/*pathology
Formins/*physiology
Myosin Type II/*metabolism
rho GTP-Binding Proteins/*metabolism
rho-Associated Kinases/*metabolism
Animals ; Cell Polarity ; Drosophila melanogaster/genetics ; Epithelial Cells/metabolism ; Female ; Male ; Mice ; Mice, Knockout ; Morphogenesis ; Myosin Type II/genetics ; rho GTP-Binding Proteins/genetics ; rho-Associated Kinases/genetics
Czasopismo naukowe
Tytuł :
ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.
Autorzy :
Boyle ST; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.
Poltavets V; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.
Kular J; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.
Pyne NT; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.
Sandow JJ; Division of Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
Lewis AC; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.; Translational Haematology Program, Peter McCallum Cancer Centre, Melbourne, Victoria, Australia.
Murphy KJ; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, St Vincent's Clinical School, University of NSW, Sydney, New South Wales, Australia.
Kolesnikoff N; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.
Moretti PAB; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.
Tea MN; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.
Tergaonkar V; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.; Institute of Molecular and Cell Biology, A*STAR and Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Timpson P; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, St Vincent's Clinical School, University of NSW, Sydney, New South Wales, Australia.
Pitson SM; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Webb AI; Division of Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
Whitfield RJ; Breast, Endocrine and Surgical Oncology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Lopez AF; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Kochetkova M; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia. .
Samuel MS; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia. .; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2020 Jul; Vol. 22 (7), pp. 882-895. Date of Electronic Publication: 2020 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Reprogramming*
Breast Neoplasms/*pathology
Cancer-Associated Fibroblasts/*pathology
Cell Adhesion Molecules/*metabolism
Extracellular Matrix Proteins/*metabolism
eIF-2 Kinase/*metabolism
rho-Associated Kinases/*metabolism
Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cancer-Associated Fibroblasts/metabolism ; Cell Adhesion Molecules/genetics ; Cells, Cultured ; Disease Models, Animal ; Endoplasmic Reticulum/metabolism ; Extracellular Matrix Proteins/genetics ; Female ; Humans ; Mice ; Paracrine Communication ; eIF-2 Kinase/genetics ; rho-Associated Kinases/genetics
Czasopismo naukowe
Tytuł :
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.
Autorzy :
You R; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Zhou W; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Li Y; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.; School of Medicine, Southeast University, Nanjing, China.
Zhang Y; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Huang S; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Jia Z; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Zhang A; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.; School of Medicine, Southeast University, Nanjing, China.
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Źródło :
Clinical science (London, England : 1979) [Clin Sci (Lond)] 2020 Jun 26; Vol. 134 (12), pp. 1357-1376.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial Cells/*enzymology
Kidney Tubules, Proximal/*pathology
Metabolic Diseases/*enzymology
rho-Associated Kinases/*antagonists & inhibitors
Adolescent ; Animals ; Anti-Inflammatory Agents/pharmacology ; Child ; Child, Preschool ; Disease Models, Animal ; Epithelial Cells/drug effects ; Female ; Fibrosis ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Humans ; Infant ; Inflammation/pathology ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Metabolic Diseases/pathology ; Mice ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Protein Kinase Inhibitors/pharmacology ; RAW 264.7 Cells ; Smad2 Protein/metabolism ; Transforming Growth Factor beta1/pharmacology ; Up-Regulation/drug effects ; Ureteral Obstruction/enzymology ; Ureteral Obstruction/pathology ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Tytuł :
Pyk2 downstream of G 12/13 pathways regulates platelet shape change through RhoA/p160 .
Autorzy :
Chaudhary PK; College of Veterinary Medicine, Chungbuk National University, Cheongju, 28644, South Korea.
Han JS; College of Agriculture & Life Sciences, Kyungpook National University, Daegu, 41566, South Korea.
Jee Y; College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, 63243, South Korea.
Lee SH; College of Veterinary Medicine, Chungbuk National University, Cheongju, 28644, South Korea.
Kim S; College of Veterinary Medicine, Chungbuk National University, Cheongju, 28644, South Korea. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jun 04; Vol. 526 (3), pp. 738-743. Date of Electronic Publication: 2020 Apr 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Platelets/*drug effects
Cell Shape/*drug effects
Focal Adhesion Kinase 2/*metabolism
GTP-Binding Protein alpha Subunits, G12-G13/*metabolism
Platelet Aggregation/*drug effects
rho-Associated Kinases/*antagonists & inhibitors
rhoA GTP-Binding Protein/*antagonists & inhibitors
Amides/metabolism ; Animals ; Blood Specimen Collection ; Disease Models, Animal ; Enzyme Inhibitors/metabolism ; Female ; Humans ; Male ; Mice ; Oligopeptides/metabolism ; Phosphorylation ; Pyridines/metabolism ; Receptor, PAR-1/metabolism ; Signal Transduction ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Tytuł :
ROCK inhibitors enhance bone healing by promoting osteoclastic and osteoblastic differentiation.
Autorzy :
Nakata J; Division of Orthodontics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan; Division of Dental Pharmacology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
Akiba Y; Division of Bio-Prosthodontics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
Nihara J; Division of Orthodontics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
Thant L; Division of Orthodontics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan; Division of Dental Pharmacology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
Eguchi K; Division of Bio-Prosthodontics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
Kato H; Division of Biomimetics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan; Research Center for Advanced Oral Science, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
Izumi K; Division of Biomimetics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
Ohkura M; Division of Orthodontics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
Otake M; Division of Orthodontics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
Kakihara Y; Division of Dental Pharmacology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan. Electronic address: .
Saito I; Division of Orthodontics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
Saeki M; Division of Dental Pharmacology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jun 04; Vol. 526 (3), pp. 547-552. Date of Electronic Publication: 2020 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives
Amides/*pharmacology
Osteogenesis/*drug effects
Protein Kinase Inhibitors/*pharmacology
Pyridines/*pharmacology
rho-Associated Kinases/*antagonists & inhibitors
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/chemistry ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/therapeutic use ; Amides/chemistry ; Amides/therapeutic use ; Animals ; Cell Differentiation ; Cell Line ; Fracture Healing/drug effects ; Male ; Mice ; Osteoblasts/cytology ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteoclasts/cytology ; Osteoclasts/drug effects ; Osteoclasts/metabolism ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/therapeutic use ; Pyridines/chemistry ; Pyridines/therapeutic use ; RAW 264.7 Cells ; Rats ; Rats, Sprague-Dawley ; Skull/drug effects ; Skull/injuries ; Skull/metabolism ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Tytuł :
Oxytocin induced epithelium-mesenchimal transition through Rho-ROCK pathway in ARPE-19 cells, a human retinal pigmental cell line.
Autorzy :
Tsuji T; Department of Ophthalmology, Faculty of Medical Sciences, Fukui University, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui, 910-1193, Japan; Department of Ophthalmology & Micro-technology, Yokohama City University, Medical School, Yokohama City University, Medical School, 4-57 Urafune-cho Minami-ku, Yokohama City, 232-0024, Japan. Electronic address: .
Inatani M; Department of Ophthalmology, Faculty of Medical Sciences, Fukui University, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui, 910-1193, Japan.
Tsuji C; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Cheranov SM; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Kadonosono K; Department of Ophthalmology & Micro-technology, Yokohama City University, Medical School, Yokohama City University, Medical School, 4-57 Urafune-cho Minami-ku, Yokohama City, 232-0024, Japan.
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Źródło :
Tissue & cell [Tissue Cell] 2020 Jun; Vol. 64, pp. 101328. Date of Electronic Publication: 2020 Feb 08.
Typ publikacji :
Journal Article
MeSH Terms :
Oxytocin/*metabolism
Retinal Pigment Epithelium/*metabolism
rho-Associated Kinases/*metabolism
Actins/metabolism ; Cell Line ; Cell Proliferation ; Collagen/metabolism ; Humans ; Isoquinolines/pharmacology ; Retina/cytology ; Retinal Pigments/metabolism ; Signal Transduction ; Sulfonamides/pharmacology ; Vitrectomy/adverse effects ; Vitrectomy/rehabilitation ; Wound Healing ; rho-Associated Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Long non-coding RNA TTN-AS1 promotes tumorigenesis of ovarian cancer through modulating the miR-139-5p/ROCK2 axis.
Autorzy :
Liu X; Department of Gynecology, The First Hospital of Jilin University, 71#Xinmin Street, Chaoyang District, Changchun, 130021, China.
Li Y; Department of Gynecology, The First Hospital of Jilin University, 71#Xinmin Street, Chaoyang District, Changchun, 130021, China.
Wen J; Department of Gynecology, The First Hospital of Jilin University, 71#Xinmin Street, Chaoyang District, Changchun, 130021, China.
Qi T; Department of Gynecology, The First Hospital of Jilin University, 71#Xinmin Street, Chaoyang District, Changchun, 130021, China.
Wang Y; Department of Gynecology, The First Hospital of Jilin University, 71#Xinmin Street, Chaoyang District, Changchun, 130021, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 May; Vol. 125, pp. 109882. Date of Electronic Publication: 2020 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Connectin/*genetics
MicroRNAs/*genetics
Ovarian Neoplasms/*genetics
RNA, Antisense/*genetics
RNA, Long Noncoding/*genetics
rho-Associated Kinases/*genetics
Animals ; Biomarkers, Tumor ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Disease Models, Animal ; Female ; Gene Knockdown Techniques ; Genes, Reporter ; Humans ; Mice ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/pathology ; Prognosis ; RNA Interference ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Tytuł :
Rho-kinase ROCK inhibitors reduce oligomeric tau protein.
Autorzy :
Hamano T; Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan; Department of Aging and Dementia (DAD), Faculty of Medical Sciences, University of Fukui, Fukui, Japan; Life Science Innovation Center, University of Fukui, Fukui, Japan. Electronic address: .
Shirafuji N; Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan; Department of Aging and Dementia (DAD), Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Yen SH; Mayo Clinic, Jacksonville, FL, USA.
Yoshida H; National Center for Geriatrics and Gerontology (NCGG), Aichi, Japan.
Kanaan NM; Department of Translational Science and Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA.
Hayashi K; Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Ikawa M; Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Yamamura O; Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Fujita Y; Department of Neurology, Fujita Neurology Hospital, Fukui, Japan.
Kuriyama M; Brain Attack Ota Memorial Hospital, Fukuyama, Japan.
Nakamoto Y; Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
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Źródło :
Neurobiology of aging [Neurobiol Aging] 2020 May; Vol. 89, pp. 41-54. Date of Electronic Publication: 2019 Dec 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*metabolism
Enzyme Inhibitors/*pharmacology
Proteolysis/*drug effects
Quinolines/*pharmacology
Tauopathies/*metabolism
rho-Associated Kinases/*antagonists & inhibitors
tau Proteins/*metabolism
Alzheimer Disease/drug therapy ; Animals ; Autophagy/drug effects ; Cell Line, Tumor ; Cells, Cultured ; Disease Models, Animal ; Humans ; Mice ; Neurofibrillary Tangles/metabolism ; Phosphorylation/drug effects ; Proteasome Endopeptidase Complex/metabolism ; Signal Transduction/drug effects ; Tauopathies/drug therapy ; rho-Associated Kinases/physiology
Czasopismo naukowe
Tytuł :
Serotonin-RhoA/ROCK axis promotes acinar-to-ductal metaplasia in caerulein-induced chronic pancreatitis.
Autorzy :
Tao X; School of Chemical Engineering, Dalian University of Technology, Dalian, China.
Chen Q; School of Chemical Engineering, Dalian University of Technology, Dalian, China.
Li N; School of Chemical Engineering, Dalian University of Technology, Dalian, China.
Xiang H; Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Pan Y; School of Chemical Engineering, Dalian University of Technology, Dalian, China.
Qu Y; School of Chemical Engineering, Dalian University of Technology, Dalian, China.
Shang D; Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Go VLW; The UCLA Agi Hirshberg Center for Pancreatic Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Xue J; Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Sun Y; Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zhang Z; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China.
Guo J; Peking Union Medical College Hospital, Beijing, China.
Xiao GG; School of Chemical Engineering, Dalian University of Technology, Dalian, China; The UCLA Agi Hirshberg Center for Pancreatic Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; Functional Genomics and Proteomics Laboratory, Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE, United States. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 May; Vol. 125, pp. 109999. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Pancreatitis, Chronic/*etiology
Pancreatitis, Chronic/*metabolism
Serotonin/*metabolism
rho-Associated Kinases/*metabolism
rhoA GTP-Binding Protein/*metabolism
Acinar Cells/metabolism ; Acinar Cells/pathology ; Animals ; Biomarkers ; Carcinoma, Pancreatic Ductal/etiology ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Transformation, Neoplastic/metabolism ; Ceruletide/adverse effects ; Disease Models, Animal ; Gene Expression Regulation ; Immunohistochemistry ; Metaplasia ; Mice ; Pancreatitis, Chronic/pathology ; rho-Associated Kinases/genetics ; rhoA GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
Targeting ROCK signaling in health, malignant and non-malignant diseases.
Autorzy :
Shahbazi R; Department of Pathology, Faculty of Veterinary Medicine, University of Tabriz, 51665-1647, Tabriz, Iran. Electronic address: .
Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, 51666-14761, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, 51666-14761, Tabriz, Iran. Electronic address: .
Khordadmehr M; Department of Pathology, Faculty of Veterinary Medicine, University of Tabriz, 51665-1647, Tabriz, Iran. Electronic address: .
Safaei S; Immunology Research Center, Tabriz University of Medical Sciences, 51666-14761, Tabriz, Iran. Electronic address: .
Baghbanzadeh A; Immunology Research Center, Tabriz University of Medical Sciences, 51666-14761, Tabriz, Iran. Electronic address: .
Jigari F; Department of Pathology, Faculty of Veterinary Medicine, University of Tabriz, 51665-1647, Tabriz, Iran. Electronic address: .
Ezzati H; Department of Pathology, Faculty of Veterinary Medicine, University of Tabriz, 51665-1647, Tabriz, Iran. Electronic address: .
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Źródło :
Immunology letters [Immunol Lett] 2020 Mar; Vol. 219, pp. 15-26. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Disease Susceptibility*
Signal Transduction*
rho-Associated Kinases/*metabolism
Animals ; Genetic Predisposition to Disease ; Humans ; MicroRNAs/genetics ; Molecular Targeted Therapy ; Multigene Family ; Mutation ; Neoplasms/drug therapy ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Structure-Activity Relationship ; rho-Associated Kinases/antagonists & inhibitors ; rho-Associated Kinases/chemistry ; rho-Associated Kinases/genetics
Czasopismo naukowe
Tytuł :
Rho kinase mediates transforming growth factor-β1-induced vasculogenic mimicry formation: involvement of the epithelial-mesenchymal transition and cancer stemness activity.
Autorzy :
Zhang X; Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, Shanghai 200080, PR China.
Zhang J; Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, Shanghai 200080, PR China.
Zhou H; Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, Shanghai 200080, PR China.
Liu G; Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, Shanghai 200080, PR China.
Li Q; Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, Shanghai 200080, PR China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2020 Apr 20; Vol. 52 (4), pp. 411-420.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition*
Neoplasms/*blood supply
Neoplasms/*metabolism
Neoplastic Stem Cells/*metabolism
Neovascularization, Pathologic/*metabolism
Transforming Growth Factor beta1/*metabolism
rho-Associated Kinases/*metabolism
Hep G2 Cells ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Neovascularization, Pathologic/genetics ; Transforming Growth Factor beta1/genetics ; rho-Associated Kinases/genetics
Czasopismo naukowe
Tytuł :
A phenotypic approach to probing cellular outcomes using heterobivalent constructs.
Autorzy :
Bhadoria R; Department of Chemistry & Biotechnology, Tallinn University of Technology, 12618 Tallinn, Estonia. .
Ping K
Lohk C
Järving I
Starkov P
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Apr 18; Vol. 56 (30), pp. 4216-4219. Date of Electronic Publication: 2020 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Kinase Inhibitors/*pharmacology
rho-Associated Kinases/*antagonists & inhibitors
Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Molecular Structure ; Particle Size ; Phenotype ; Protein Kinase Inhibitors/chemistry ; Surface Properties ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Tytuł :
Salvianolic acid B protects against oxLDL-induced endothelial dysfunction under high-glucose conditions by downregulating ROCK1-mediated mitophagy and apoptosis.
Autorzy :
Ko YS; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea.
Jin H; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea.
Park SW; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea.
Kim HJ; Department of Pharmacology, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Apr; Vol. 174, pp. 113815. Date of Electronic Publication: 2020 Jan 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzofurans/*pharmacology
Endothelial Cells/*metabolism
Glucose/*toxicity
Lipoproteins, LDL/*toxicity
Mitophagy/*physiology
rho-Associated Kinases/*metabolism
Apoptosis/drug effects ; Apoptosis/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Down-Regulation/drug effects ; Down-Regulation/physiology ; Drugs, Chinese Herbal/pharmacology ; Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Mitophagy/drug effects ; rho-Associated Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Determination of KD025 (SLx-2119), a Selective ROCK2 Inhibitor, in Rat Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and its Pharmacokinetic Application.
Autorzy :
Yoon JH; Department of Pharmacy, College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Korea.
Nguyen TT; Department of Pharmacy, College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Korea.
Duong VA; Department of Pharmacy, College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Korea.
Chun KH; Department of Pharmacy, College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Korea.
Maeng HJ; Department of Pharmacy, College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Mar 17; Vol. 25 (6). Date of Electronic Publication: 2020 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Tandem Mass Spectrometry*
Heterocyclic Compounds, 4 or More Rings/*blood
Heterocyclic Compounds, 4 or More Rings/*pharmacokinetics
Protein Kinase Inhibitors/*blood
Protein Kinase Inhibitors/*pharmacokinetics
rho-Associated Kinases/*antagonists & inhibitors
Administration, Oral ; Animals ; Chromatography, High Pressure Liquid ; Heterocyclic Compounds, 4 or More Rings/administration & dosage ; Indazoles/blood ; Niacinamide/analogs & derivatives ; Niacinamide/blood ; Protein Kinase Inhibitors/administration & dosage ; Rats, Sprague-Dawley ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Tytuł :
Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis.
Autorzy :
Stankiewicz TR; University of Denver, Department of Biological Sciences, Denver, CO 80208, United States.
Pena C; University of Denver, Department of Biological Sciences, Denver, CO 80208, United States.
Bouchard RJ; Research Service, Veterans Affairs Medical Center, Denver, CO, 80220, United States.
Linseman DA; University of Denver, Department of Biological Sciences, Eleanor Roosevelt Institute, and Knoebel Institute for Healthy Aging, 2155 E. Wesley Ave., Denver, CO, 80208, United States. Electronic address: .
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Źródło :
Neurobiology of disease [Neurobiol Dis] 2020 Mar; Vol. 136, pp. 104743. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amyotrophic Lateral Sclerosis/*metabolism
GTP Phosphohydrolases/*metabolism
Motor Neurons/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Superoxide Dismutase/*physiology
rho-Associated Kinases/*metabolism
Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; Cell Death/physiology ; Female ; GTP Phosphohydrolases/genetics ; Male ; Mice ; Mice, Transgenic ; Motor Neurons/pathology ; Mutation/physiology ; Proto-Oncogene Proteins c-akt/genetics ; rho-Associated Kinases/genetics
Czasopismo naukowe

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