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Tytuł :
SARS-CoV-2 N-antigenemia in critically ill adult COVID-19 patients: Frequency and association with inflammatory and tissue-damage biomarkers.
Autorzy :
Olea B; Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Albert E; Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Torres I; Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Gozalbo-Rovira R; Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain.
Carbonell N; Medical Intensive Care Unit, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Ferreres J; Medical Intensive Care Unit, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Poujois S; Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Costa R; Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Colomina J; Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Rodríguez-Díaz J; Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain.
Blasco ML; Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain.
Navarro D; Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.; Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain.
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Źródło :
Journal of medical virology [J Med Virol] 2022 Jan; Vol. 94 (1), pp. 222-228. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Critical Illness*
SARS-CoV-2*/genetics
SARS-CoV-2*/immunology
SARS-CoV-2*/isolation & purification
COVID-19/*virology
Coronavirus Nucleocapsid Proteins/*blood
Adult ; Aged ; Aged, 80 and over ; Antigens, Viral/blood ; Biomarkers/analysis ; Biomarkers/blood ; COVID-19/mortality ; Coronavirus Nucleocapsid Proteins/immunology ; Female ; Humans ; Inflammation ; Male ; Middle Aged ; Phosphoproteins/blood ; Phosphoproteins/immunology ; Prospective Studies ; RNA, Viral/analysis ; RNA, Viral/blood ; Trachea/virology ; Young Adult
Czasopismo naukowe
Tytuł :
Assessment of SARS-CoV-2 Immunity in Convalescent Children and Adolescents.
Autorzy :
Tsang HW; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Chua GT; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
To KKW; State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Wong JSC; Department of Paediatrics and Adolescent Medicine, Prince Margaret Hospital, Hospital Authority, Hong Kong, Hong Kong SAR, China.
Tu W; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Kwok JSY; Department of Pathology, Queen Mary Hospital, Hospital Authority, Hong Kong, Hong Kong SAR, China.
Wong WHS; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Wang X; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Zhang Y; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Rosa Duque JS; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Chan GCF; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Chu WK; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Pang CP; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Tam PKH; Department of Surgery and Dr. Li Dak Sam Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.; Faculty of Medicine, Macau University of Science and Technology, Macau, Macau SAR, China.
Lau YL; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Wong ICK; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Leung WH; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Yuen KY; State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Kwan MYW; Department of Paediatrics and Adolescent Medicine, Prince Margaret Hospital, Hospital Authority, Hong Kong, Hong Kong SAR, China.
Ip P; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Dec 17; Vol. 12, pp. 797919. Date of Electronic Publication: 2021 Dec 17 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Convalescence*
Adaptive Immunity/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Adolescent ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/virology ; COVID-19/virology ; Child ; Child, Preschool ; Female ; Humans ; Immunity, Humoral/immunology ; Immunoglobulin G/immunology ; Male ; SARS-CoV-2/metabolism ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
A Comparative Study between Spanish and British SARS-CoV-2 Variants.
Autorzy :
Jimenez Ruiz JA; Research Group on Electronic Technology and Industrial Computing (TIC-150), Department of Artificial Intelligence, University of Seville, 41013 Sevilla, Spain.
Lopez Ramirez C; Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, 41013 Sevilla, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Lopez-Campos JL; Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, 41013 Sevilla, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
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Źródło :
Current issues in molecular biology [Curr Issues Mol Biol] 2021 Nov 16; Vol. 43 (3), pp. 2036-2047. Date of Electronic Publication: 2021 Nov 16.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Virus Internalization*
COVID-19/*virology
SARS-CoV-2/*genetics
SARS-CoV-2/*physiology
Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/metabolism ; Base Sequence ; COVID-19/epidemiology ; COVID-19/metabolism ; COVID-19/pathology ; Computational Biology ; Humans ; Protein Binding ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Sequence Alignment ; Spain/epidemiology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; United Kingdom/epidemiology
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Investigating the first stage of the COVID-19 pandemic in Ukraine using epidemiological and genomic data.
Autorzy :
Gankin Y; Quantori, Cambridge, Massachusetts, United States of America.
Nemira A; Department of Computer Science, Georgia State University, Atlanta, Georgia, United States of America.
Koniukhovskii V; EPAM Systems, Saint Petersburg, Russian Federation.
Chowell G; Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, Georgia, United States of America.
Weppelmann TA; Department of Internal Medicine, University of South Florida, Tampa, Florida, United States.
Skums P; Department of Computer Science, Georgia State University, Atlanta, Georgia, United States of America.
Kirpich A; Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, Georgia, United States of America. Electronic address: .
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Źródło :
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2021 Nov; Vol. 95, pp. 105087. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genome, Viral*
Models, Statistical*
COVID-19/*epidemiology
COVID-19/*transmission
SARS-CoV-2/*genetics
SARS-CoV-2/*pathogenicity
COVID-19/virology ; China/epidemiology ; Epidemiological Monitoring ; Europe/epidemiology ; Humans ; Incidence ; North America/epidemiology ; Phylogeny ; Physical Distancing ; SARS-CoV-2/classification ; SARS-CoV-2/isolation & purification ; Travel/statistics & numerical data ; Ukraine/epidemiology
Czasopismo naukowe
Tytuł :
Investigating the possible origin and transmission routes of SARS-CoV-2 genomes and variants of concern in Bangladesh.
Autorzy :
Al Nahid A; Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh.
Ghosh A; Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh. Electronic address: .
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Źródło :
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2021 Nov; Vol. 95, pp. 105057. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article
MeSH Terms :
Genome, Viral*
COVID-19/*epidemiology
COVID-19/*transmission
SARS-CoV-2/*genetics
SARS-CoV-2/*pathogenicity
Adolescent ; Adult ; Africa/epidemiology ; Aged ; Aged, 80 and over ; Australia/epidemiology ; Bangladesh/epidemiology ; COVID-19/virology ; Child ; Epidemiological Monitoring ; Europe/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Molecular Epidemiology ; Phylogeny ; SARS-CoV-2/classification ; SARS-CoV-2/isolation & purification ; Sequence Analysis, RNA ; Travel/statistics & numerical data ; United States/epidemiology
Czasopismo naukowe
Tytuł :
Comparison of SARS-CoV-2 variant lethality in human angiotensin-converting enzyme 2 transgenic mice.
Autorzy :
Lee TY; Division of Emerging Virus & Vector Research, Center for Emerging Virus Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 187 Osongsaengmyeong2-ro, Cheongju-si, Chungbuk, Republic of Korea.
Lee H; Division of Emerging Virus & Vector Research, Center for Emerging Virus Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 187 Osongsaengmyeong2-ro, Cheongju-si, Chungbuk, Republic of Korea.
Kim N; Division of Emerging Virus & Vector Research, Center for Emerging Virus Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 187 Osongsaengmyeong2-ro, Cheongju-si, Chungbuk, Republic of Korea.
Jeon P; Division of Emerging Virus & Vector Research, Center for Emerging Virus Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 187 Osongsaengmyeong2-ro, Cheongju-si, Chungbuk, Republic of Korea.
Kim JW; Division of Emerging Virus & Vector Research, Center for Emerging Virus Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 187 Osongsaengmyeong2-ro, Cheongju-si, Chungbuk, Republic of Korea.
Lim HY; Division of Emerging Virus & Vector Research, Center for Emerging Virus Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 187 Osongsaengmyeong2-ro, Cheongju-si, Chungbuk, Republic of Korea.
Yang JS; Division of Emerging Virus & Vector Research, Center for Emerging Virus Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 187 Osongsaengmyeong2-ro, Cheongju-si, Chungbuk, Republic of Korea.
Kim KC; Division of Emerging Virus & Vector Research, Center for Emerging Virus Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 187 Osongsaengmyeong2-ro, Cheongju-si, Chungbuk, Republic of Korea.
Lee JY; Center for Emerging Virus Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea. Electronic address: .
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Źródło :
Virus research [Virus Res] 2021 Nov; Vol. 305, pp. 198563. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*genetics
COVID-19/*mortality
Receptors, Virus/*genetics
SARS-CoV-2/*genetics
SARS-CoV-2/*pathogenicity
Viral Load/*genetics
Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Base Sequence ; Body Weight ; COVID-19/pathology ; COVID-19/virology ; Chlorocebus aethiops ; Gene Expression ; Humans ; Lethal Dose 50 ; Male ; Mice ; Mice, Transgenic ; Phylogeny ; Receptors, Virus/metabolism ; SARS-CoV-2/classification ; SARS-CoV-2/metabolism ; Severity of Illness Index ; Survival Analysis ; Transgenes ; Vero Cells ; Viral Plaque Assay ; Virulence
Czasopismo naukowe
Tytuł :
Membrane-Based In-Gel Loop-Mediated Isothermal Amplification (mgLAMP) System for SARS-CoV-2 Quantification in Environmental Waters.
Autorzy :
Zhu Y; Linde Laboratories, California Institute of Technology, Pasadena, California 91125, United States.
Wu X; Linde Laboratories, California Institute of Technology, Pasadena, California 91125, United States.
Gu A; Linde Laboratories, California Institute of Technology, Pasadena, California 91125, United States.
Dobelle L; Linde Laboratories, California Institute of Technology, Pasadena, California 91125, United States.
Cid CA; Linde Laboratories, California Institute of Technology, Pasadena, California 91125, United States.
Li J; Linde Laboratories, California Institute of Technology, Pasadena, California 91125, United States.
Hoffmann MR; Linde Laboratories, California Institute of Technology, Pasadena, California 91125, United States.
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Źródło :
Environmental science & technology [Environ Sci Technol] 2022 Jan 18; Vol. 56 (2), pp. 862-873. Date of Electronic Publication: 2021 Dec 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*
SARS-CoV-2*
Humans ; Molecular Diagnostic Techniques ; Nucleic Acid Amplification Techniques ; Pandemics ; RNA, Viral ; Sensitivity and Specificity
SCR Protocol :
LAMP assay
Czasopismo naukowe
Tytuł :
An overview of human proteins and genes involved in SARS-CoV-2 infection.
Autorzy :
Jahanafrooz Z; Department of Biology, Faculty of Sciences, University of Maragheh, Maragheh, Iran. Electronic address: .
Chen Z; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Bao J; College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China.
Li H; Department of Molecular Medicine, City of Hope National Medical Center, Duarte, CA 91010, USA.
Lipworth L; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Guo X; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37203, USA. Electronic address: .
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Źródło :
Gene [Gene] 2022 Jan 15; Vol. 808, pp. 145963. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19/*metabolism
Host Microbial Interactions/*genetics
SARS-CoV-2/*metabolism
COVID-19/physiopathology ; Computational Biology/methods ; Cryoelectron Microscopy/methods ; Crystallography, X-Ray/methods ; Genome-Wide Association Study ; Host Microbial Interactions/physiology ; Host-Pathogen Interactions/genetics ; Humans ; Proteins/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity
Czasopismo naukowe
Tytuł :
Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2.
Autorzy :
Wang YT; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
Long XY; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, PR China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, 650204, PR China.
Ding X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
Fan SR; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
Cai JY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
Yang BJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
Zhang XF; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China; Department of Chemical Science and Engineering, Yunnan University, Kunming, Yunnan, 650091, PR China.
Luo RH; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, PR China.
Yang L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
Ruan T; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, 650204, PR China.
Ren J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China; Department of Chemical Science and Engineering, Yunnan University, Kunming, Yunnan, 650091, PR China.
Jing CX; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
Zheng YT; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, PR China. Electronic address: .
Hao XJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China. Electronic address: .
Chen DZ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2022 Jan 05; Vol. 227, pp. 113966. Date of Electronic Publication: 2021 Nov 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemistry
Coronavirus Nucleocapsid Proteins/*antagonists & inhibitors
Phenanthridines/*chemistry
SARS-CoV-2/*metabolism
Animals ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Binding Sites ; COVID-19/drug therapy ; COVID-19/virology ; Cell Survival/drug effects ; Chlorocebus aethiops ; Coronavirus Nucleocapsid Proteins/metabolism ; Drug Design ; Humans ; Kinetics ; Molecular Docking Simulation ; Phenanthridines/metabolism ; Phenanthridines/pharmacology ; Phenanthridines/therapeutic use ; Phosphoproteins/antagonists & inhibitors ; Phosphoproteins/metabolism ; Protein Binding ; Protein Structure, Tertiary ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology ; Vero Cells
Czasopismo naukowe
Tytuł :
Dynamics of SARS-CoV-2 variants of concern (VOC) in Bangladesh during the first half of 2021.
Autorzy :
Afrin SZ; Department of Microbiology, Sheikh Hasina Medical College, Tangail, Bangladesh.
Islam MT; Population Medicine and AMR Laboratory, Department of Medicine, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, 2202, Bangladesh.
Paul SK; Department of Microbiology, Netrokona Medical College, Netrokona, Bangladesh.
Kobayashi N; Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
Parvin R; Department of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, 2202, Bangladesh. Electronic address: .
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Źródło :
Virology [Virology] 2022 Jan 02; Vol. 565, pp. 29-37. Date of Electronic Publication: 2021 Oct 22.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*virology
SARS-CoV-2/*genetics
Bangladesh/epidemiology ; Binding Sites ; COVID-19/epidemiology ; Female ; Genome, Viral/genetics ; Humans ; Male ; Mutation ; Phylogeny ; Prevalence ; SARS-CoV-2/classification ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/genetics
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Fruit Bromelain-Derived Peptide Potentially Restrains the Attachment of SARS-CoV-2 Variants to hACE2: A Pharmacoinformatics Approach.
Autorzy :
Tallei TE; Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado 95115, Indonesia.; The University Centre of Excellence for Biotechnology and Conservation of Wallacea, Institute for Research and Community Services, Sam Ratulangi University, Manado 95115, Indonesia.
Fatimawali; The University Centre of Excellence for Biotechnology and Conservation of Wallacea, Institute for Research and Community Services, Sam Ratulangi University, Manado 95115, Indonesia.; Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado 95115, Indonesia.
Adam AA; Dentistry Study Program, Faculty of Medicine, Sam Ratulangi University, Manado 95115, Indonesia.
Elseehy MM; Department of Genetics, Faculty of Agriculture, University of Alexandria, Alexandria 21545, Egypt.
El-Shehawi AM; Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Mahmoud EA; Department of Food Industries, Faculty of Agriculture, Damietta University, Damietta 34511, Egypt.
Tania AD; Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado 95115, Indonesia.
Niode NJ; The University Centre of Excellence for Biotechnology and Conservation of Wallacea, Institute for Research and Community Services, Sam Ratulangi University, Manado 95115, Indonesia.; Department of Dermatology and Venereology, Faculty of Medicine, University of Sam Ratulangi, RD Kandou Hospital, Manado 95163, Indonesia.
Kusumawaty D; Department of Biology, Faculty of Mathematics and Natural Sciences Education, Universitas Pendidikan Indonesia, Bandung 40154, Indonesia.
Rahimah S; Food Technology Study Program, Department of Food Industrial Technology, Faculty of Agroindustrial Technology, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Effendi Y; Department of Biology, Faculty of Science and Technology, Al-Azhar Indonesia University, Jakarta 12110, Indonesia.
Idroes R; Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Kopelma Darussalam, Banda Aceh 23111, Indonesia.
Celik I; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38039, Turkey.
Hossain MJ; Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka 1205, Bangladesh.
Emran TB; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2022 Jan 01; Vol. 27 (1). Date of Electronic Publication: 2022 Jan 01.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2*/chemistry
Bromelains*/chemistry
Bromelains*/pharmacology
Computer Simulation*
Protein Interaction Domains and Motifs*
SARS-CoV-2*/chemistry
SARS-CoV-2*/drug effects
Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; COVID-19/drug therapy ; Models, Molecular ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Peptides/chemistry ; Peptides/pharmacology ; Protein Binding ; Spike Glycoprotein, Coronavirus/chemistry
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
COVID-19: an In Silico Analysis on Potential Therapeutic Uses of Trikadu as Immune System Boosters.
Autorzy :
Khasamwala RH; School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India, 600048.
Ranjani S; School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India, 600048.
Nivetha SS; School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India, 600048.
Hemalatha S; School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India, 600048. .
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Źródło :
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2022 Jan; Vol. 194 (1), pp. 291-301. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Phytotherapy*
SARS-CoV-2*/chemistry
SARS-CoV-2*/drug effects
SARS-CoV-2*/immunology
COVID-19/*drug therapy
COVID-19/*immunology
Plant Preparations/*therapeutic use
Antioxidants/isolation & purification ; Antioxidants/therapeutic use ; COVID-19/virology ; Computer Simulation ; Coronavirus RNA-Dependent RNA Polymerase/chemistry ; Coronavirus RNA-Dependent RNA Polymerase/drug effects ; Dietary Supplements ; Ginger/chemistry ; Humans ; Immune System/drug effects ; India ; Ligands ; Medicine, Traditional ; Molecular Docking Simulation ; Phytochemicals/chemistry ; Phytochemicals/therapeutic use ; Piper/chemistry ; Piper nigrum/chemistry ; Plant Preparations/isolation & purification ; Plants, Medicinal/chemistry ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/drug effects
Czasopismo naukowe
Tytuł :
Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2.
Autorzy :
Huang KA; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Zhou D; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Tan TK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Chen C; Medigen Vaccine Biologics Corporation, Taipei, Taiwan.; Temple University, Philadelphia, PA 19122, USA.
Duyvesteyn HME; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Zhao Y; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Ginn HM; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Qin L; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Rijal P; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Schimanski L; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Donat R; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Harding A; Sir William Dunn School of Pathology, South Park Road, University of Oxford, UK.
Gilbert-Jaramillo J; Sir William Dunn School of Pathology, South Park Road, University of Oxford, UK.
James W; Sir William Dunn School of Pathology, South Park Road, University of Oxford, UK.
Tree JA; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Buttigieg K; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Carroll M; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Charlton S; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Lien CE; Medigen Vaccine Biologics Corporation, Taipei, Taiwan.; Institute of Public Health, National Yang-Ming Chiao Tung University, Taipei, Taiwan.
Lin MY; Medigen Vaccine Biologics Corporation, Taipei, Taiwan.
Chen CP; Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, and National Yang-Ming University, Taipei, Taiwan.
Cheng SH; Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, and Taipei Medical University, Taipei, Taiwan.
Chen X; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Lin TY; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Fry EE; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Ren J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Ma C; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Townsend AR; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Stuart DI; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
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Źródło :
Theranostics [Theranostics] 2022 Jan 01; Vol. 12 (1), pp. 1-17. Date of Electronic Publication: 2022 Jan 01 (Print Publication: 2022).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*chemistry
Antibodies, Monoclonal/*pharmacology
COVID-19/*drug therapy
SARS-CoV-2/*metabolism
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antibodies, Monoclonal/metabolism ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/pharmacology ; Binding Sites ; Binding, Competitive ; COVID-19/virology ; Cricetinae ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Dogs ; Epitopes ; Female ; Humans ; Madin Darby Canine Kidney Cells ; Neutralization Tests ; Protein Domains ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Quality comparability assessment of a SARS-CoV-2-neutralizing antibody across transient, mini-pool-derived and single-clone CHO cells.
Autorzy :
Xu G; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Yu C; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Wang W; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Fu C; Shanghai Junshi Biosciences Co. Ltd, Shanghai, China.
Liu H; Shanghai Junshi Biosciences Co. Ltd, Shanghai, China.
Zhu Y; Shanghai Junshi Biosciences Co. Ltd, Shanghai, China.
Li Y; Shanghai Junshi Biosciences Co. Ltd, Shanghai, China.
Liu C; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Fu Z; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Wu G; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Li M; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Guo S; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Yu X; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Du J; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Yang Y; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Duan M; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Cui Y; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
Feng H; Shanghai Junshi Biosciences Co. Ltd, Shanghai, China.
Wang L; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, China National Institutes for Food and Drug Control, Beijing, China.
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Źródło :
MAbs [MAbs] 2022 Jan-Dec; Vol. 14 (1), pp. 2005507.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/therapeutic use ; Antibody Affinity/immunology ; Antibody Specificity/immunology ; CHO Cells ; COVID-19/prevention & control ; COVID-19/virology ; Chromatography, High Pressure Liquid/methods ; Circular Dichroism ; Clone Cells ; Cricetinae ; Cricetulus ; Humans ; Immunoglobulin G/chemistry ; Immunoglobulin G/immunology ; Immunoglobulin G/therapeutic use ; Isoelectric Point ; SARS-CoV-2/metabolism ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
Nicotinic receptors as SARS-CoV-2 spike co-receptors?
Autorzy :
Dormoy V; University of Reims Champagne-Ardenne, Inserm, P3Cell UMR-S1250, SFR CAP-SANTE, 51092 Reims, France.
Perotin JM; University of Reims Champagne-Ardenne, Inserm, P3Cell UMR-S1250, SFR CAP-SANTE, 51092 Reims, France.; CHU of Reims, Hôpital Maison Blanche, Department of Respiratory Diseases, 51092 Reims, France.
Gosset P; University of Lille, CNRS UMR8204, Inserm U1019, CHRU Lille, Institut Pasteur Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
Maskos U; Institut Pasteur Paris, Université de Paris, Integrative Neurobiology of Cholinergic Systems, CNRS, UMR 3571, Paris, France.
Polette M; University of Reims Champagne-Ardenne, Inserm, P3Cell UMR-S1250, SFR CAP-SANTE, 51092 Reims, France.; CHU Reims, Hôpital Maison Blanche, Department of Biopathology, 51092 Reims, France.
Deslée G; University of Reims Champagne-Ardenne, Inserm, P3Cell UMR-S1250, SFR CAP-SANTE, 51092 Reims, France.; CHU of Reims, Hôpital Maison Blanche, Department of Respiratory Diseases, 51092 Reims, France.
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Źródło :
Medical hypotheses [Med Hypotheses] 2022 Jan; Vol. 158, pp. 110741. Date of Electronic Publication: 2021 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, Nicotinic*
Receptors, Virus*
SARS-CoV-2*
Spike Glycoprotein, Coronavirus*
COVID-19 ; Humans
Czasopismo naukowe
Tytuł :
Evolution of viral variants in remdesivir-treated and untreated SARS-CoV-2-infected pediatrics patients.
Autorzy :
Boshier FAT; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Pang J; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.; Division of Infection and Immunity, University College London, London, UK.
Penner J; Department of Infectious Disease, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Parker M; Department of Infection, Immunity and Cardiovascular Diseases, The Florey Institute, University of Sheffield, Sheffield, UK.
Alders N; Department of Infectious Disease, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Bamford A; Department of Infectious Disease, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Grandjean L; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Grunewald S; Department of Metabolic Medicine, UCL Great Ormond Street Institute of Child Health, London, UK.
Hatcher J; Department of Microbiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Best T; Department of Microbiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Dalton C; Department of Pharmacy, Great Ormond Street Hospital for Children NHS Trust, London, UK.
Bynoe PD; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Frauenfelder C; Department of Ears, Nose and Throat, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.; Division of Surgery, University of Adelaide, Adelaide, South Australia, Australia.
Köeglmeier J; Department of Gastroenterology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Myerson P; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Roy S; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Williams R; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
de Silva TI; Department of Infection, Immunity and Cardiovascular Diseases, The Florey Institute, University of Sheffield, Sheffield, UK.
Goldstein RA; Division of Infection and Immunity, University College London, London, UK.
Breuer J; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.; Department of Microbiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
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Corporate Authors :
COVID-19 Genomics UK (COG-UK) consortium
Źródło :
Journal of medical virology [J Med Virol] 2022 Jan; Vol. 94 (1), pp. 161-172. Date of Electronic Publication: 2021 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Evolution, Molecular*
Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
COVID-19/*virology
SARS-CoV-2/*genetics
Adenosine Monophosphate/therapeutic use ; Adolescent ; Alanine/therapeutic use ; Child ; Child, Preschool ; Drug Resistance, Viral ; Female ; Haplotypes ; Humans ; Infant ; Lung/virology ; Male ; Phylogeny ; RNA, Viral/analysis ; RNA, Viral/genetics ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology ; Viral Load ; Virus Replication/drug effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp).
Autorzy :
Bibi S; Yunnan Herbal Laboratory, College of Ecology and Environmental Sciences, Yunnan University, Kunming 650091, Yunnan,China.
Hasan MM; Department of Biochemistry and Molecular Biology, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Tangail 1902,Bangladesh.
Wang YB; Yunnan Herbal Laboratory, College of Ecology and Environmental Sciences, Yunnan University, Kunming 650091, Yunnan,China.
Papadakos SP; First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens,Greece.
Yu H; Yunnan Herbal Laboratory, College of Ecology and Environmental Sciences, Yunnan University, Kunming 650091, Yunnan,China.
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Źródło :
Current medicinal chemistry [Curr Med Chem] 2022; Vol. 29 (1), pp. 152-162.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents*/pharmacology
SARS-CoV-2*/drug effects
SARS-CoV-2*/enzymology
Deoxyadenosines/*pharmacology
RNA-Dependent RNA Polymerase/*antagonists & inhibitors
COVID-19 ; Humans ; Molecular Docking Simulation ; RNA, Viral
Czasopismo naukowe

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