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Tytuł :
β Cell GHS-R Regulates Insulin Secretion and Sensitivity.
Autorzy :
Pradhan G; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Wu CS; Department of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Villarreal D; Department of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Lee JH; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Marine Bioindustry, Hanseo University, Seosan 31962, Korea.
Han HW; Department of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Gaharwar A; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.
Tian Y; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, USA.
Fu W; Department of Pediatrics, University of California, San Diego, CA 92161, USA.
Guo S; Department of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Smith RG; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL 33458, USA.
Sun Y; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Nutrition, Texas A&M University, College Station, TX 77843, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 11; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 11.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin Secretion*
Insulin-Secreting Cells/*metabolism
Receptors, Ghrelin/*metabolism
Animals ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Mice ; Mice, Knockout ; Receptors, Ghrelin/genetics
Czasopismo naukowe
Tytuł :
A Type VI Secretion System Facilitates Fitness, Homeostasis, and Competitive Advantages for Environmental Adaptability and Efficient Nicotine Biodegradation.
Autorzy :
Li J; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Xie L; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Qian S; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Tang Y; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Shen M; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Li S; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Wang J; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Xiong L; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Lu J; Department of Infectious Diseases, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China .
Zhong W; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China .
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Źródło :
Applied and environmental microbiology [Appl Environ Microbiol] 2021 Apr 13; Vol. 87 (9). Date of Electronic Publication: 2021 Apr 13 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*metabolism
Nicotine/*metabolism
Pseudomonas/*metabolism
Type VI Secretion Systems/*metabolism
Bacterial Proteins/genetics ; Biodegradation, Environmental ; Homeostasis ; Multigene Family ; Pseudomonas/genetics ; Reactive Oxygen Species/metabolism ; Type VI Secretion Systems/genetics
Czasopismo naukowe
Tytuł :
In Situ LSPR Sensing of Secreted Insulin in Organ-on-Chip.
Autorzy :
Ortega MA; Biosensors for Bioengineering Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Baldiri I Reixac, 10-12, 08028 Barcelona, Spain.
Rodríguez-Comas J; Biosensors for Bioengineering Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Baldiri I Reixac, 10-12, 08028 Barcelona, Spain.
Yavas O; Plasmon Nano-Optics Group, ICFO-Institute for Photonics Sciences, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain.
Velasco-Mallorquí F; Biosensors for Bioengineering Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Baldiri I Reixac, 10-12, 08028 Barcelona, Spain.
Balaguer-Trias J; Biosensors for Bioengineering Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Baldiri I Reixac, 10-12, 08028 Barcelona, Spain.
Parra V; Biosensors for Bioengineering Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Baldiri I Reixac, 10-12, 08028 Barcelona, Spain.
Novials A; Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas (CIBERDEM), 28029 Madrid, Spain.
Servitja JM; Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas (CIBERDEM), 28029 Madrid, Spain.
Quidant R; Plasmon Nano-Optics Group, ICFO-Institute for Photonics Sciences, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain.; Nanophotonic Systems Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland.; ICREA-Institució Catalana de Recerca i Estudis Avançats, 08010 Barcelona, Spain.
Ramón-Azcón J; Biosensors for Bioengineering Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Baldiri I Reixac, 10-12, 08028 Barcelona, Spain.; ICREA-Institució Catalana de Recerca i Estudis Avançats, 08010 Barcelona, Spain.
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Źródło :
Biosensors [Biosensors (Basel)] 2021 Apr 28; Vol. 11 (5). Date of Electronic Publication: 2021 Apr 28.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques*
Insulin Secretion*
Animals ; Diabetes Mellitus, Type 2 ; Drug Discovery ; Drug Evaluation, Preclinical ; Humans ; Insulins ; Lab-On-A-Chip Devices ; Oligonucleotide Array Sequence Analysis ; Surface Plasmon Resonance
Czasopismo naukowe
Tytuł :
IP 6 -assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion.
Autorzy :
Lin H; School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Yan Y; School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Luo Y; School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.; School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong.
So WY; Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, Singapore, Singapore.
Wei X; School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Zhang X; School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Yang X; School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Zhang J; School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Su Y; School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Yang X; School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Zhang B; School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Zhang K; Department of Hepatic Surgery, the Third People's Hospital of Shenzhen and the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
Jiang N; Department of Hepatic Surgery, the Third People's Hospital of Shenzhen and the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
Chow BKC; School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong.
Han W; Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, Singapore, Singapore.
Wang F; National Institute of Biological Sciences, Beijing, China.
Rao F; School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 28; Vol. 12 (1), pp. 2461. Date of Electronic Publication: 2021 Apr 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins/*metabolism
Insulin Secretion/*physiology
Insulin-Secreting Cells/*metabolism
Nuclear Proteins/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Transcription Factors/*metabolism
Ubiquitin-Protein Ligase Complexes/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; COP9 Signalosome Complex/metabolism ; Cell Line ; Cyclopentanes/pharmacology ; Diabetes Mellitus/drug therapy ; Enzyme Inhibitors/pharmacology ; Glucose/metabolism ; HEK293 Cells ; Humans ; Hyperinsulinism/drug therapy ; Insulin Secretion/genetics ; Mice ; Mice, Inbred C57BL ; Obesity/drug therapy ; Pyrimidines/pharmacology
Czasopismo naukowe
Tytuł :
Adhesive Functions or Pseudogenization of Type Va Autotransporters in Brucella Species.
Autorzy :
Bialer MG; Fundación Instituto Leloir (FIL), IIBBA (CONICET-FIL), Buenos Aires, Argentina.
Ferrero MC; Facultad de Farmacia y Bioquímica, Cátedra de Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina.; Instituto de Estudios de la Inmunidad Humoral (IDEHU), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina.
Delpino MV; Instituto de Inmunología, Genética y Metabolismo (INIGEM), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina.
Ruiz-Ranwez V; Fundación Instituto Leloir (FIL), IIBBA (CONICET-FIL), Buenos Aires, Argentina.
Posadas DM; Fundación Instituto Leloir (FIL), IIBBA (CONICET-FIL), Buenos Aires, Argentina.
Baldi PC; Facultad de Farmacia y Bioquímica, Cátedra de Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina.; Instituto de Estudios de la Inmunidad Humoral (IDEHU), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina.
Zorreguieta A; Fundación Instituto Leloir (FIL), IIBBA (CONICET-FIL), Buenos Aires, Argentina.; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
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Źródło :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2021 Apr 27; Vol. 11, pp. 607610. Date of Electronic Publication: 2021 Apr 27 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brucella suis*/genetics
Type V Secretion Systems*/genetics
Adhesins, Bacterial/genetics ; Adhesives ; Brucella abortus
Czasopismo naukowe
Tytuł :
iT4SE-EP: Accurate Identification of Bacterial Type IV Secreted Effectors by Exploring Evolutionary Features from Two PSI-BLAST Profiles.
Autorzy :
Han H; College of Information Technology, Shanghai Ocean University, Shanghai 201306, China.
Ding C; College of Information Technology, Shanghai Ocean University, Shanghai 201306, China.
Cheng X; College of Information Technology, Shanghai Ocean University, Shanghai 201306, China.
Sang X; College of Information Technology, Shanghai Ocean University, Shanghai 201306, China.
Liu T; College of Information Technology, Shanghai Ocean University, Shanghai 201306, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 24; Vol. 26 (9). Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Evolution, Molecular*
Gram-Negative Bacteria/*genetics
Host-Pathogen Interactions/*genetics
Type IV Secretion Systems/*genetics
Amino Acid Sequence/genetics ; Bacterial Infections/drug therapy ; Bacterial Infections/genetics ; Bacterial Infections/microbiology ; Computational Biology ; Gram-Negative Bacteria/pathogenicity ; Humans ; Type IV Secretion Systems/chemistry
Czasopismo naukowe
Tytuł :
Identification and study of InV as an inverse autotransporter family representative in Edwardsiella piscicida.
Autorzy :
Han Y; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Wei L; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Xiao J; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Zhang Y; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.; Shanghai Collaborative Innovation Center for Biomanufacturing, 130 Meilong Road, Shanghai, 200237, China.; Shanghai Engineering Research Center of Maricultured Animal Vaccines, Shanghai, China.
Wang Q; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China. .; Shanghai Collaborative Innovation Center for Biomanufacturing, 130 Meilong Road, Shanghai, 200237, China. .; Shanghai Engineering Research Center of Maricultured Animal Vaccines, Shanghai, China. .
Zhou M; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China. .
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Źródło :
Archives of microbiology [Arch Microbiol] 2020 Jul; Vol. 202 (5), pp. 1107-1116. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji :
Journal Article
MeSH Terms :
Adhesins, Bacterial/*genetics
Edwardsiella/*genetics
Edwardsiella/*pathogenicity
Type III Secretion Systems/*genetics
Animals ; Cell Line, Tumor ; Gene Library ; HeLa Cells ; Humans ; Type III Secretion Systems/metabolism ; Type V Secretion Systems/genetics ; Virulence/genetics ; Virulence Factors/genetics ; Zebrafish/microbiology
SCR Organism :
Edwardsiella piscicida
Czasopismo naukowe
Tytuł :
Bacterial injection machines: Evolutionary diverse but functionally convergent.
Autorzy :
Bleves S; LISM (Laboratoire d'Ingénierie des Systèmes Macromoléculaires-UMR7255), IMM (Institut de Microbiologie de la Méditerranée), Aix-Marseille Univ and CNRS, Marseille, France.
Galán JE; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut.
Llosa M; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC-SODERCAN, Santander, Spain.
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Źródło :
Cellular microbiology [Cell Microbiol] 2020 May; Vol. 22 (5), pp. e13157. Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacteria/*metabolism
Bacterial Proteins/*metabolism
Bacterial Secretion Systems/*metabolism
Bacteria/genetics ; Bacterial Proteins/genetics ; Bacterial Secretion Systems/chemistry ; Bacterial Secretion Systems/genetics ; Humans ; Protein Transport ; Spain ; Type III Secretion Systems/genetics ; Type III Secretion Systems/metabolism ; Type IV Secretion Systems/genetics ; Type IV Secretion Systems/metabolism ; Type VI Secretion Systems/genetics ; Type VI Secretion Systems/metabolism ; Virulence
Czasopismo naukowe
Tytuł :
Assembly and Subcellular Localization of Bacterial Type VI Secretion Systems.
Autorzy :
Wang J; Biozentrum, University of Basel, CH 4056 Basel, Switzerland; email: .
Brodmann M; Biozentrum, University of Basel, CH 4056 Basel, Switzerland; email: .
Basler M; Biozentrum, University of Basel, CH 4056 Basel, Switzerland; email: .
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Źródło :
Annual review of microbiology [Annu Rev Microbiol] 2019 Sep 08; Vol. 73, pp. 621-638. Date of Electronic Publication: 2019 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Type VI Secretion Systems*/biosynthesis
Type VI Secretion Systems*/chemistry
Type VI Secretion Systems*/metabolism
Type VI Secretion Systems*/ultrastructure
Gram-Negative Bacteria/*metabolism
Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Bacterial Secretion Systems ; Cell Membrane/metabolism ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/metabolism ; Lipoproteins/chemistry ; Lipoproteins/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Secondary structure and transmembrane topology analysis of the N-terminal domain of the inner membrane protein EccE 1 from M. smegmatis using site-directed spin labeling EPR.
Autorzy :
Yu L; High Magnetic Field Laboratory, Chinese Academy of Science, Hefei, Anhui 230031, China. Electronic address: .
Fang W; Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.
He Y; Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.
Cai W; School of Life Sciences, Anhui University, 111 Jiulong Road, Hefei, Anhui 230601, China.
Wei W; Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
Tian C; High Magnetic Field Laboratory, Chinese Academy of Science, Hefei, Anhui 230031, China; Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2021 Feb 01; Vol. 1863 (2), pp. 183515. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Micelles*
Mycobacterium smegmatis/*chemistry
Type VII Secretion Systems/*chemistry
Electron Spin Resonance Spectroscopy ; Mycobacterium smegmatis/genetics ; Mycobacterium smegmatis/metabolism ; Mycobacterium tuberculosis/chemistry ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/metabolism ; Protein Domains ; Protein Structure, Secondary ; Spin Labels ; Type VII Secretion Systems/genetics ; Type VII Secretion Systems/metabolism
Czasopismo naukowe
Tytuł :
A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation.
Autorzy :
Yang L; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Lei XT; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China.
Huang Q; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
Wang T; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China. Electronic address: .
Sun HB; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China. Electronic address: .
Wang HY; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 119029. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin Secretion*/drug effects
Inflammation/*pathology
Receptors, G-Protein-Coupled/*agonists
Adipose Tissue/pathology ; Animals ; Chronic Disease ; Glucagon-Like Peptide 1/metabolism ; Glucose/pharmacology ; Inflammation/blood ; Insulin Resistance ; Lipopolysaccharides/pharmacology ; Liver/pathology ; Mice ; Mice, Inbred C57BL ; RAW 264.7 Cells ; Receptors, G-Protein-Coupled/metabolism
Czasopismo naukowe
Tytuł :
Baicalin Represses Type Three Secretion System of Pseudomonas aeruginosa through PQS System.
Autorzy :
Zhang P; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China.
Guo Q; College of Natural Resources and Environment, Northwest A&F University, Yangling 712100, China.
Wei Z; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China.
Yang Q; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China.
Guo Z; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China.
Shen L; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China.
Duan K; Department of Oral Biology & Medical Microbiology & Infectious Diseases, Rady Faculty of Health Sciences, University of Manitoba, 780 Bannatyne Ave., Winnipeg, MB R3E 0W2, Canada.
Chen L; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Mar 10; Vol. 26 (6). Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Flavonoids/*pharmacology
Quinolones/*metabolism
Type III Secretion Systems/*metabolism
Animals ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Biofilms/drug effects ; China ; Drosophila Proteins/drug effects ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; Female ; Flavonoids/metabolism ; Models, Animal ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/metabolism ; Quorum Sensing/drug effects ; Rats ; Rats, Sprague-Dawley ; Transcription Factors/therapeutic use ; Type III Secretion Systems/drug effects ; Virulence/drug effects ; Virulence Factors
Czasopismo naukowe
Tytuł :
Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation.
Autorzy :
Miletic S; University Medical Center Hamburg-Eppendorf (UKE), Institute of Structural and Systems Biology, Hamburg, Germany.; Centre for Structural Systems Biology (CSSB), Hamburg, Germany.; Deutsches Elektronen-Synchrotron Zentrum (DESY), Hamburg, Germany.; Institute of Molecular Biotechnology GmbH (IMBA), Austrian Academy of Sciences, Vienna, Austria.; Research Institute of Molecular Pathology (IMP), Vienna, Austria.
Fahrenkamp D; University Medical Center Hamburg-Eppendorf (UKE), Institute of Structural and Systems Biology, Hamburg, Germany.; Centre for Structural Systems Biology (CSSB), Hamburg, Germany.; Deutsches Elektronen-Synchrotron Zentrum (DESY), Hamburg, Germany.
Goessweiner-Mohr N; University Medical Center Hamburg-Eppendorf (UKE), Institute of Structural and Systems Biology, Hamburg, Germany.; Deutsches Elektronen-Synchrotron Zentrum (DESY), Hamburg, Germany.; Institute of Molecular Biotechnology GmbH (IMBA), Austrian Academy of Sciences, Vienna, Austria.; Research Institute of Molecular Pathology (IMP), Vienna, Austria.
Wald J; University Medical Center Hamburg-Eppendorf (UKE), Institute of Structural and Systems Biology, Hamburg, Germany.; Centre for Structural Systems Biology (CSSB), Hamburg, Germany.; Deutsches Elektronen-Synchrotron Zentrum (DESY), Hamburg, Germany.; Institute of Molecular Biotechnology GmbH (IMBA), Austrian Academy of Sciences, Vienna, Austria.; Research Institute of Molecular Pathology (IMP), Vienna, Austria.
Pantel M; University Medical Center Hamburg-Eppendorf (UKE), Institute of Structural and Systems Biology, Hamburg, Germany.; Centre for Structural Systems Biology (CSSB), Hamburg, Germany.; Deutsches Elektronen-Synchrotron Zentrum (DESY), Hamburg, Germany.
Vesper O; University Medical Center Hamburg-Eppendorf (UKE), Institute of Structural and Systems Biology, Hamburg, Germany.; Centre for Structural Systems Biology (CSSB), Hamburg, Germany.; Deutsches Elektronen-Synchrotron Zentrum (DESY), Hamburg, Germany.; Institute of Molecular Biotechnology GmbH (IMBA), Austrian Academy of Sciences, Vienna, Austria.; Research Institute of Molecular Pathology (IMP), Vienna, Austria.
Kotov V; University Medical Center Hamburg-Eppendorf (UKE), Institute of Structural and Systems Biology, Hamburg, Germany.; Centre for Structural Systems Biology (CSSB), Hamburg, Germany.; Deutsches Elektronen-Synchrotron Zentrum (DESY), Hamburg, Germany.; Institute of Molecular Biotechnology GmbH (IMBA), Austrian Academy of Sciences, Vienna, Austria.; Research Institute of Molecular Pathology (IMP), Vienna, Austria.
Marlovits TC; University Medical Center Hamburg-Eppendorf (UKE), Institute of Structural and Systems Biology, Hamburg, Germany. .; Centre for Structural Systems Biology (CSSB), Hamburg, Germany. .; Deutsches Elektronen-Synchrotron Zentrum (DESY), Hamburg, Germany. .; Institute of Molecular Biotechnology GmbH (IMBA), Austrian Academy of Sciences, Vienna, Austria. .; Research Institute of Molecular Pathology (IMP), Vienna, Austria. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 09; Vol. 12 (1), pp. 1546. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*chemistry
Bacterial Proteins/*metabolism
Protein Transport/*physiology
Salmonella typhimurium/*metabolism
Type III Secretion Systems/*chemistry
Type III Secretion Systems/*metabolism
Antigens, Bacterial/chemistry ; Antigens, Bacterial/genetics ; Antigens, Bacterial/metabolism ; Bacterial Proteins/genetics ; Cryoelectron Microscopy ; Membrane Proteins/chemistry ; Membrane Proteins/metabolism ; Models, Molecular ; Protein Conformation, alpha-Helical ; Salmonella enterica/metabolism ; Salmonella typhimurium/genetics ; Type III Secretion Systems/genetics
Czasopismo naukowe
Tytuł :
Conventional and Unconventional Mechanisms by which Exocytosis Proteins Oversee β-cell Function and Protection.
Autorzy :
Chatterjee Bhowmick D; Department of Molecular and Cellular Endocrinology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Ahn M; Department of Molecular and Cellular Endocrinology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Oh E; Department of Molecular and Cellular Endocrinology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Veluthakal R; Department of Molecular and Cellular Endocrinology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Thurmond DC; Department of Molecular and Cellular Endocrinology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 12; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Exocytosis*
Insulin Secretion*
Diabetes Mellitus, Type 2/*metabolism
Insulin/*metabolism
Insulin-Secreting Cells/*metabolism
SNARE Proteins/*metabolism
Animals ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/pathology ; Humans ; Insulin/genetics ; Insulin-Secreting Cells/pathology ; SNARE Proteins/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Induced secretion system mutation alters rhizosphere bacterial composition in Sorghum bicolor (L.) Moench.
Autorzy :
Balasubramanian VK; Fiber and Biopolymer Research Institute (FBRI), Department of Plant and Soil Science, Texas Tech University, Lubbock, TX, 79409, USA.
Dampanaboina L; Department of Plant and Soil Science, Texas Tech University, Lubbock, 79409, USA. .
Cobos CJ; Fiber and Biopolymer Research Institute (FBRI), Department of Plant and Soil Science, Texas Tech University, Lubbock, TX, 79409, USA.
Yuan N; Fiber and Biopolymer Research Institute (FBRI), Department of Plant and Soil Science, Texas Tech University, Lubbock, TX, 79409, USA.
Xin Z; USDA-ARS, Lubbock, TX, USA.
Mendu V; Fiber and Biopolymer Research Institute (FBRI), Department of Plant and Soil Science, Texas Tech University, Lubbock, TX, 79409, USA. .
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Źródło :
Planta [Planta] 2021 Jan 18; Vol. 253 (2), pp. 33. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article
MeSH Terms :
Bacterial Secretion Systems*/genetics
Rhizosphere*
Soil Microbiology*
Sorghum*/genetics
Sorghum*/microbiology
Bacteria/genetics ; Mutation ; Plant Roots/microbiology
Czasopismo naukowe
Tytuł :
Commiphora myrrha stimulates insulin secretion from mouse and human islets of Langerhans.
Autorzy :
Al-Romaiyan A; Department of Pharmacology & Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait. Electronic address: .
Huang GC; Department of Diabetes, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, UK. Electronic address: .
Jones P; Department of Diabetes, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, UK. Electronic address: .
Persaud S; Department of Diabetes, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, UK. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Jan 10; Vol. 264, pp. 113075. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Commiphora*
Insulin Secretion/*drug effects
Islets of Langerhans/*drug effects
Islets of Langerhans/*metabolism
Plant Extracts/*pharmacology
Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Humans ; Insulin Secretion/physiology ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Mice ; Mice, Inbred BALB C ; Plant Extracts/isolation & purification
Czasopismo naukowe
Tytuł :
Structural Characterization of the Type IX Secretion System in Porphyromonas gingivalis.
Autorzy :
Gorasia DG; Oral Health Cooperative Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, Australia.
Hanssen E; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, Australia.; Advanced Microscopy Facility, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, Australia.
Veith PD; Oral Health Cooperative Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, Australia. .
Reynolds EC; Oral Health Cooperative Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, Australia. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2210, pp. 113-121.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Secretion Systems/*metabolism
Porphyromonas gingivalis/*metabolism
Adhesins, Bacterial/genetics ; Adhesins, Bacterial/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Bacterial Secretion Systems/genetics ; Mass Spectrometry/methods ; Microscopy, Electron/methods ; Porphyromonas gingivalis/genetics ; Protein Sorting Signals/genetics
Czasopismo naukowe
Tytuł :
First-phase insulin secretion is positively correlated with alanine aminotransferase in young adults.
Autorzy :
Wu CZ; Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taiwan.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Hsieh CH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Lu CH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Pei D; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Fu Jen Catholic University Hospital, New Taipei City, Taiwan.
Chen JS; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Taiwan.; Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chen YL; Department of Pathology, Cardinal Tien Hospital, Fu Jen Catholic University, School of Medicine, New Taipei City, Taiwan.
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Źródło :
Advances in clinical and experimental medicine : official organ Wroclaw Medical University [Adv Clin Exp Med] 2021 Jan; Vol. 30 (1), pp. 35-40.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin Resistance*
Insulin Secretion*
Metabolic Syndrome*/diagnosis
Adolescent ; Adult ; Alanine Transaminase ; Cholesterol, HDL ; Female ; Humans ; Male ; Young Adult
Czasopismo naukowe
Tytuł :
Effect of Gymnema sylvestre Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance.
Autorzy :
Gaytán Martínez LA; Department of Physiology, Institute of Experimental and Clinical Therapeutics, Health Science University Center, University of Guadalajara, Guadalajara, Mexico.
Sánchez-Ruiz LA; Department of Physiology, Institute of Experimental and Clinical Therapeutics, Health Science University Center, University of Guadalajara, Guadalajara, Mexico.
Zuñiga LY; Department of Physiology, Institute of Experimental and Clinical Therapeutics, Health Science University Center, University of Guadalajara, Guadalajara, Mexico.
González-Ortiz M; Department of Physiology, Institute of Experimental and Clinical Therapeutics, Health Science University Center, University of Guadalajara, Guadalajara, Mexico.
Martínez-Abundis E; Department of Physiology, Institute of Experimental and Clinical Therapeutics, Health Science University Center, University of Guadalajara, Guadalajara, Mexico.
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Źródło :
Journal of medicinal food [J Med Food] 2021 Jan; Vol. 24 (1), pp. 28-32. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Glucose Intolerance*/drug therapy
Insulin Resistance*
Insulin Secretion*
Gymnema sylvestre/*chemistry
Plant Preparations/*therapeutic use
Blood Glucose ; Double-Blind Method ; Glycemic Control ; Humans ; India ; Insulin/metabolism ; Phytotherapy
Czasopismo naukowe
Tytuł :
Identification of Type III Secretion Inhibitors for Plant Disease Management.
Autorzy :
de Pedro Jové R; Department of Genetics, University of Barcelona, Barcelona, Catalonia, Spain.; Centre for Research in Agricultural Genomics (CSIC-IRTA-UAB-UB), Bellaterra, Catalonia, Spain.
Sebastià P; Centre for Research in Agricultural Genomics (CSIC-IRTA-UAB-UB), Bellaterra, Catalonia, Spain.
Valls M; Department of Genetics, University of Barcelona, Barcelona, Catalonia, Spain. .; Centre for Research in Agricultural Genomics (CSIC-IRTA-UAB-UB), Bellaterra, Catalonia, Spain. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2213, pp. 39-48.
Typ publikacji :
Journal Article
MeSH Terms :
Lycopersicon esculentum/*microbiology
Plant Diseases/*microbiology
Plant Diseases/*prevention & control
Tobacco/*microbiology
Type III Secretion Systems/*antagonists & inhibitors
Plant Leaves/microbiology ; Ralstonia solanacearum/growth & development ; Ralstonia solanacearum/pathogenicity ; Type III Secretion Systems/metabolism ; Virulence
Czasopismo naukowe

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