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Wyszukujesz frazę ""senescence"" wg kryterium: Temat


Tytuł :
A novel indenone derivative selectively induces senescence in MDA-MB-231 (breast adenocarcinoma) cells.
Autorzy :
Priyanga J; Cellular Dyshomeostasis Laboratory, Department of Biotechnology, School of Chemical and Bio Technology, SASTRA University, Thanjavur, Tamil Nadu, India.
Sharan Kumar B; Cellular Dyshomeostasis Laboratory, Department of Biotechnology, School of Chemical and Bio Technology, SASTRA University, Thanjavur, Tamil Nadu, India.
Mahalakshmi R; Cellular Dyshomeostasis Laboratory, Department of Biotechnology, School of Chemical and Bio Technology, SASTRA University, Thanjavur, Tamil Nadu, India.
Nirekshana K; Cellular Dyshomeostasis Laboratory, Department of Biotechnology, School of Chemical and Bio Technology, SASTRA University, Thanjavur, Tamil Nadu, India.
Vinoth P; Department of Chemistry, School of Chemical and Bio Technology, SASTRA University, Thanjavur, Tamil Nadu, India.
Sridharan V; Department of Chemistry and Chemical Sciences, Central University of Jammu, Rahya-Suchani (Bagla), Samba, Jammu, India.
Bhakta-Guha D; Cellular Dyshomeostasis Laboratory, Department of Biotechnology, School of Chemical and Bio Technology, SASTRA University, Thanjavur, Tamil Nadu, India. Electronic address: .
Guha G; Cellular Dyshomeostasis Laboratory, Department of Biotechnology, School of Chemical and Bio Technology, SASTRA University, Thanjavur, Tamil Nadu, India. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 Nov 01; Vol. 331, pp. 109250. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*/drug effects
Antineoplastic Agents/*chemical synthesis
Sulfonamides/*chemistry
Antineoplastic Agents/pharmacology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Catalysis ; Cell Line, Tumor ; Cell Survival/drug effects ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Down-Regulation/drug effects ; Female ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Palladium/chemistry ; Sulfonamides/chemical synthesis ; Survivin/metabolism ; Tumor Suppressor Protein p53/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts.
Autorzy :
Guan Y; Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.; Institute of Clinical Medicine, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang 524000, China.
Zhang C; Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.; Center for Bioinformatics, School of Life Sciences and Center for Statistical Science, Peking University, Beijing 100871, China.
Lyu G; Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
Huang X; Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
Zhang X; Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
Zhuang T; Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
Jia L; Center for Bioinformatics, School of Life Sciences and Center for Statistical Science, Peking University, Beijing 100871, China.
Zhang L; Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
Zhang C; China Department of Neurobiology, School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China.
Li C; Center for Bioinformatics, School of Life Sciences and Center for Statistical Science, Peking University, Beijing 100871, China.
Tao W; Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 04; Vol. 48 (19), pp. 10909-10923.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Gene Expression Regulation*
Aging/*genetics
Fibroblasts/*cytology
Animals ; Cells, Cultured ; Chromatin/metabolism ; Embryo, Mammalian ; Mice ; Mice, Inbred C57BL ; Rats ; Rats, Sprague-Dawley ; Regulatory Sequences, Nucleic Acid
Czasopismo naukowe
Tytuł :
Comparison of senescence progression in mesenchymal cells from human umbilical cord walls measured by immunofluorescence and flow cytometry of p16 and p21.
Autorzy :
Silva AD; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Piccinato CA; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Sardinha LR; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Aloia TPA; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Goldberg AC; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
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Źródło :
Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2020 Oct 16; Vol. 18, pp. eAO5236. Date of Electronic Publication: 2020 Oct 16 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Flow Cytometry/*methods
Fluorescent Antibody Technique/*methods
Mesenchymal Stem Cells/*physiology
Umbilical Cord/*physiology
Biomarkers/blood ; Blotting, Western ; Cells, Cultured ; Cyclin-Dependent Kinase Inhibitor p16 ; Cyclin-Dependent Kinase Inhibitor p21 ; Humans
Czasopismo naukowe
Tytuł :
Cannabinoids as anti-ROS in aged pancreatic islet cells.
Autorzy :
Baeeri M; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Rahimifard M; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Daghighi SM; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Khan F; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Salami SA; Department of Biotechnology, University of Tehran, Tehran, Iran.
Moini-Nodeh S; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Haghi-Aminjan H; Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
Bayrami Z; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Rezaee F; Department of Cell Biology, University of Groningen, Groningen, the Netherlands; Department of Gastroenterology-Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands.
Abdollahi M; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 01; Vol. 256, pp. 117969. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*/drug effects
Cannabinoids/*pharmacology
Islets of Langerhans/*cytology
Reactive Oxygen Species/*metabolism
Animals ; Biomarkers/metabolism ; Cannabidiol/pharmacology ; Cell Survival/drug effects ; Dronabinol/pharmacology ; Homeodomain Proteins/metabolism ; Insulin Secretion/drug effects ; Male ; Oxidative Stress/drug effects ; Rats, Wistar ; Trans-Activators/metabolism
Czasopismo naukowe
Tytuł :
Low-Level Nanog Expression in the Regulation of Quiescent Endothelium.
Autorzy :
Baruah J; From the Department of Psychiatry, Harvard Medical School, Boston, MA (J.B.).; Angiogenesis and Brain Development Laboratory, Division of Basic Neuroscience, McLean Hospital, Belmont, MA (J.B.).
Chaudhuri S; Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Mastej V; Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Axen C; Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Hitzman R; Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Ribeiro IMB; Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Wary KK; Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Sep; Vol. 40 (9), pp. 2244-2264. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*/drug effects
Cellular Senescence*/drug effects
Coronary Vessels/*metabolism
Endothelial Cells/*metabolism
Endothelium, Vascular/*metabolism
Nanog Homeobox Protein/*metabolism
Animals ; Apoptosis ; Cells, Cultured ; Coronary Vessels/drug effects ; Coronary Vessels/pathology ; Endothelial Cells/drug effects ; Endothelial Cells/pathology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/pathology ; Female ; Fibrosis ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Nanog Homeobox Protein/deficiency ; Nanog Homeobox Protein/genetics ; Neovascularization, Physiologic ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Telomerase/genetics ; Telomerase/metabolism ; Transcriptional Activation ; Wnt Signaling Pathway ; Wnt3A Protein/pharmacology
Czasopismo naukowe
Tytuł :
Biology of extracellular vesicles secreted from senescent cells as senescence-associated secretory phenotype factors.
Autorzy :
Misawa T; Project for Cellular Senescence, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Tanaka Y; Project for Cellular Senescence, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Okada R; Project for Cellular Senescence, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Takahashi A; Project for Cellular Senescence, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Saitama, Japan.; Advanced Research & Development Programs for Medical Innovation (PRIME), Japan Agency for Medical Research and Development (AMED), Tokyo, Japan.
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Źródło :
Geriatrics & gerontology international [Geriatr Gerontol Int] 2020 Jun; Vol. 20 (6), pp. 539-546. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cellular Senescence*
Extracellular Vesicles/*metabolism
Aging/physiology ; Cell Transformation, Neoplastic/metabolism ; Exosomes/metabolism ; Humans ; Phenotype
Czasopismo naukowe
Tytuł :
Thyroid hormone induces cellular senescence in prostate cancer cells through induction of DEC1.
Autorzy :
Kotolloshi R; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Mirzakhani K; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Ahlburg J; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Kraft F; Institute of Human Genetics, Jena University Hospital, Jena, Germany; Institute of Human Genetics, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Pungsrinont T; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Baniahmad A; Institute of Human Genetics, Jena University Hospital, Jena, Germany. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2020 Jul; Vol. 201, pp. 105689. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Homeodomain Proteins/*metabolism
Prostatic Neoplasms/*metabolism
Thyroid Hormones/*metabolism
Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Line, Tumor ; Cell Proliferation ; Cyclin-Dependent Kinase Inhibitor p15/genetics ; Cyclin-Dependent Kinase Inhibitor p15/metabolism ; Homeodomain Proteins/genetics ; Humans ; Male ; Prostatic Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Targeting senescent cells to attenuate cardiovascular disease progression.
Autorzy :
Song P; Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA, 30303, United States. Electronic address: .
Zhao Q; Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA, 30303, United States.
Zou MH; Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA, 30303, United States.
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Źródło :
Ageing research reviews [Ageing Res Rev] 2020 Jul; Vol. 60, pp. 101072. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Cardiovascular Diseases*/drug therapy
Cardiovascular Diseases*/prevention & control
Cardiovascular System*
Cellular Senescence*
Aging ; Disease Progression ; Humans
Czasopismo naukowe
Tytuł :
Link between increased cellular senescence and extracellular matrix changes in COPD.
Autorzy :
Woldhuis RR; Department of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.; Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.; University of Technology Sydney, Sydney, Australia.
de Vries M; Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Timens W; Department of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
van den Berge M; Department of Pulmonary Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Demaria M; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Oliver BGG; Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.; University of Technology Sydney, Sydney, Australia.
Heijink IH; Department of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Brandsma CA; Department of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2020 Jul 01; Vol. 319 (1), pp. L48-L60. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Extracellular Matrix/*metabolism
Pulmonary Disease, Chronic Obstructive/*pathology
Adult ; Age of Onset ; Biomarkers/metabolism ; Cells, Cultured ; DNA Damage ; Female ; Fibroblasts/pathology ; Gene Expression Regulation ; Humans ; Lung/pathology ; Lung/physiopathology ; Male ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Middle Aged ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Oxidative Stress ; Paraquat/toxicity ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/physiopathology
Czasopismo naukowe
Tytuł :
Uncoupled inflammatory, proliferative, and cytoskeletal responses in senescent human gingival fibroblasts.
Autorzy :
Páez J; Faculty of Dentistry, Universidad Andrés Bello, Santiago, Chile.
Hernández R; Faculty of Medicine, School of Dentistry, Pontificia Universidad Católica de Chile, Santiago, Chile.
Espinoza J; Faculty of Medicine, School of Dentistry, Pontificia Universidad Católica de Chile, Santiago, Chile.
Rojas L; Faculty of Medicine, School of Dentistry, Pontificia Universidad Católica de Chile, Santiago, Chile.
Martínez CE; Faculty of Medicine, School of Dentistry, Pontificia Universidad Católica de Chile, Santiago, Chile.
Tobar N; Laboratory of Cell Biology, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
Martínez J; Laboratory of Cell Biology, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
Smith PC; Faculty of Dentistry, Universidad Andrés Bello, Santiago, Chile.
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Źródło :
Journal of periodontal research [J Periodontal Res] 2020 Jun; Vol. 55 (3), pp. 432-440. Date of Electronic Publication: 2020 Jan 14.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation*
Cellular Senescence*
Cytoskeleton/*physiology
Fibroblasts/*cytology
Aging ; Cells, Cultured ; Gingiva/cytology ; Humans
Czasopismo naukowe
Tytuł :
Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children.
Autorzy :
Chen S; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address: .
Wang WW; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address: .
Wang Y; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address: .
Li YQ; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address: .
Zhu LX; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address: .
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Źródło :
International journal of pediatric otorhinolaryngology [Int J Pediatr Otorhinolaryngol] 2020 Jun; Vol. 133, pp. 110004. Date of Electronic Publication: 2020 Mar 14.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Macrophages/*physiology
Palatine Tonsil/*pathology
Tonsillitis/*pathology
Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Child ; Germinal Center/pathology ; Humans ; Hypertrophy/pathology ; Hypertrophy/surgery ; Recurrence ; Tonsillectomy ; Tonsillitis/surgery
Czasopismo naukowe
Tytuł :
Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies.
Autorzy :
Saheera S; Department of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Potnuri AG; Department of Animal Physiology, Indian Council for Medical Research-National Animal Resource Facility for Biomedical Research, Genome Valley, Shamirpet, Hyderabad, Telangana 500078, India.
Krishnamurthy P; Department of Biomedical Engineering, School of Medicine and School of Engineering, The University of Alabama at Birmingham, 1675 University Blvd, Volker Hall G094, Birmingham, AL 35294, USA.
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Źródło :
Cells [Cells] 2020 Aug 26; Vol. 9 (9). Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Cell Communication*
Cellular Senescence*
Aging/*metabolism
Cardiovascular Diseases/*metabolism
Coronavirus Infections/*metabolism
Diabetes Mellitus/*metabolism
Exosomes/*metabolism
Extracellular Vesicles/*metabolism
Neurodegenerative Diseases/*metabolism
Pneumonia, Viral/*metabolism
Aged ; Aged, 80 and over ; Animals ; Betacoronavirus ; Biomarkers/metabolism ; Coronavirus Infections/virology ; Humans ; Mice ; Pandemics ; Pneumonia, Viral/virology
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.
Autorzy :
Schleich K; Charité - University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Augustenburger Platz 1, 13353, Berlin, Germany.
Kase J; Charité - University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Augustenburger Platz 1, 13353, Berlin, Germany.
Dörr JR; Charité - University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Augustenburger Platz 1, 13353, Berlin, Germany.
Trescher S; Institute for Computer Science, Humboldt-Universität zu Berlin, Unter Den Linden 6, 10099, Berlin, Germany.
Bhattacharya A; Charité - University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Augustenburger Platz 1, 13353, Berlin, Germany.
Yu Y; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Robert-Rössle-Straße 10, 13125, Berlin, Germany.
Wailes EM; Charité - University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Augustenburger Platz 1, 13353, Berlin, Germany.
Fan DNY; Charité - University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Augustenburger Platz 1, 13353, Berlin, Germany.; Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin, Berlin, Germany.
Lohneis P; University Hospital Cologne, Pathology, Kerpener Straße 62, 50937, Cologne, Germany.
Milanovic M; Charité - University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Augustenburger Platz 1, 13353, Berlin, Germany.
Lau A; Charité - University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Augustenburger Platz 1, 13353, Berlin, Germany.
Lenze D; Charité - University Medical Center, Pathology, Charitéplatz 1, 10117, Berlin, Germany.
Hummel M; Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin, Berlin, Germany.; Charité - University Medical Center, Pathology, Charitéplatz 1, 10117, Berlin, Germany.
Chapuy B; University Medical Center Göttingen, Department of Hematology and Medical Oncology, Robert-Koch-Straße 40, 37075, Göttingen, Germany.
Leser U; Institute for Computer Science, Humboldt-Universität zu Berlin, Unter Den Linden 6, 10099, Berlin, Germany.
Reimann M; Charité - University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Augustenburger Platz 1, 13353, Berlin, Germany.
Lee S; Charité - University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Augustenburger Platz 1, 13353, Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Robert-Rössle-Straße 10, 13125, Berlin, Germany.; Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin, Berlin, Germany.
Schmitt CA; Charité - University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Augustenburger Platz 1, 13353, Berlin, Germany. .; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Robert-Rössle-Straße 10, 13125, Berlin, Germany. .; Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin, Berlin, Germany. .; Kepler University Hospital, Department of Hematology and Oncology, Johannes Kepler University, Krankenhausstraße 9, 4020, Linz, Austria. .; Berlin Institute of Health, Anna-Louisa-Karsch-Straße 2, 10178, Berlin, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 20; Vol. 11 (1), pp. 3651. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Histone Methyltransferases*/genetics
Histone Methyltransferases*/metabolism
Lymphoma, Large B-Cell, Diffuse*/genetics
Lymphoma, Large B-Cell, Diffuse*/pathology
3T3 Cells ; Animals ; Cell Line, Tumor ; Disease Models, Animal ; Epigenesis, Genetic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Transgenic ; Prognosis
Czasopismo naukowe
Tytuł :
A programmable fate decision landscape underlies single-cell aging in yeast.
Autorzy :
Li Y; Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Jiang Y; Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Paxman J; Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
O'Laughlin R; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Klepin S; Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Zhu Y; Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Pillus L; Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.; UCSD Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Tsimring LS; BioCircuits Institute, University of California San Diego, La Jolla, CA 92093, USA.
Hasty J; Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.; BioCircuits Institute, University of California San Diego, La Jolla, CA 92093, USA.
Hao N; Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA. .; BioCircuits Institute, University of California San Diego, La Jolla, CA 92093, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Jul 17; Vol. 369 (6501), pp. 325-329.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Saccharomyces cerevisiae*
Mitochondria/*physiology
Chromatin/physiology ; Chromatin Assembly and Disassembly ; DNA, Fungal ; Gene Silencing
Czasopismo naukowe
Tytuł :
AP-1 imprints a reversible transcriptional programme of senescent cells.
Autorzy :
Martínez-Zamudio RI; Institut Pasteur, Paris, France.; INSERM U993, Paris, France.; Center for Cell Signaling, Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School of Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ, USA.
Roux PF; Institut Pasteur, Paris, France.; INSERM U993, Paris, France.; Johnson & Johnson, Upstream Skin Research, Issy-les-Moulineaux, France.
de Freitas JANLF; Institut Pasteur, Paris, France.; INSERM U993, Paris, France.; Université de Paris, Sorbonne Paris Cité, Paris, France.
Robinson L; Institut Pasteur, Paris, France.; INSERM U993, Paris, France.; Université de Paris, Sorbonne Paris Cité, Paris, France.
Doré G; Institut Pasteur, Paris, France.; INSERM U993, Paris, France.
Sun B; MRC London Institute of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK.
Belenki D; Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Charité-University Medical Center, Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Milanovic M; Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Charité-University Medical Center, Berlin, Germany.; Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Berlin, Germany.
Herbig U; Center for Cell Signaling, Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School of Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ, USA.
Schmitt CA; Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Charité-University Medical Center, Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Berlin, Germany.; Department of Hematology and Oncology, Kepler University Hospital, Johannes Kepler University, Linz, Austria.
Gil J; MRC London Institute of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK.
Bischof O; Institut Pasteur, Paris, France. .; INSERM U993, Paris, France. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2020 Jul; Vol. 22 (7), pp. 842-855. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Epigenesis, Genetic*
Gene Expression Regulation*
Transcriptome*
Chromatin/*metabolism
Fibroblasts/*cytology
Histones/*metabolism
Transcription Factor AP-1/*metabolism
Animals ; Chromatin/genetics ; Female ; Fibroblasts/metabolism ; Histones/genetics ; Humans ; Mice, Inbred C57BL ; Transcription Factor AP-1/genetics
Czasopismo naukowe
Tytuł :
SIRT7 slows down stem cell aging by preserving heterochromatin: a perspective on the new discovery.
Autorzy :
Sun L; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, 77030, USA.
Dang W; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, 77030, USA. .
Pokaż więcej
Źródło :
Protein & cell [Protein Cell] 2020 Jul; Vol. 11 (7), pp. 469-471.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Cellular Senescence*
Heterochromatin*
Aging ; Humans ; Sirtuins/genetics ; Stem Cells
Czasopismo naukowe
Tytuł :
ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin.
Autorzy :
Hu H; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Ji Q; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Song M; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Ren J; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.; China National Center for Bioinformation, Beijing 100101, China.; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Liu Z; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Wang Z; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Liu X; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Yan K; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Hu J; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Jing Y; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; School of Future Technology, University of Chinese Academy of Sciences, Beijing 100190, China.
Wang S; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang W; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.; China National Center for Bioinformation, Beijing 100101, China.; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Liu GH; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Qu J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jun 19; Vol. 48 (11), pp. 6001-6018.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*/genetics
Epigenesis, Genetic*
Heterochromatin/*metabolism
Transcription Factors/*metabolism
Animals ; Down-Regulation ; Heterochromatin/genetics ; Humans ; Male ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/pathology ; Mice ; Transcription Factors/deficiency
Czasopismo naukowe
Tytuł :
Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling.
Autorzy :
Lin KY; Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, National Chung Hsing University and Academia Sinica, Taipei, 11529, Taiwan.; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, 40227, Taiwan.; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan.
Wang WD; Department of BioAgricultural Sciences, National Chiayi University, Chiayi City, 60004, Taiwan.
Lin CH; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan.
Rastegari E; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan.
Su YH; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan.
Chang YT; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan.
Liao YF; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan.
Chang YC; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan.
Pi H; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan.
Yu BY; Institute of Information Science, Academia Sinica, Taipei, 11529, Taiwan.
Chen SH; Institute of Information Science, Academia Sinica, Taipei, 11529, Taiwan.
Lin CY; Institute of Information Science, Academia Sinica, Taipei, 11529, Taiwan.
Lu MY; Biodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan.
Su TY; Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, 10617, Taiwan.
Tzou FY; Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, 10617, Taiwan.
Chan CC; Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, 10617, Taiwan.
Hsu HJ; Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, National Chung Hsing University and Academia Sinica, Taipei, 11529, Taiwan. .; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan. .; Biotechnology Center, National Chung Hsing University, Taichung, 40227, Taiwan. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Jun 19; Vol. 11 (1), pp. 3147. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Drosophila melanogaster*/genetics
Drosophila melanogaster*/metabolism
Argonaute Proteins/*metabolism
Drosophila Proteins/*metabolism
Germ Cells/*metabolism
Animals ; Argonaute Proteins/genetics ; Cadherins/metabolism ; Drosophila Proteins/genetics ; Female ; Gene Silencing ; Glycogen Synthase Kinase 3/metabolism ; Ovary/cytology ; Ovary/metabolism ; Retroelements/genetics ; Signal Transduction ; Stem Cell Niche/physiology ; Stem Cells/metabolism ; Toll-Like Receptors/metabolism ; beta Catenin/metabolism
Czasopismo naukowe

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