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Wyszukujesz frazę ""senescence"" wg kryterium: Temat


Starter badań:

Tytuł:
IFN-γ and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma.
Autorzy:
Homann L; Department of Dermatology, University of Tuebingen, 72076 Tuebingen, Germany.
Rentschler M; Department of Dermatology, University of Tuebingen, 72076 Tuebingen, Germany.; Institute of Physiology I, Department of Vegetative and Clinical Physiology, University of Tuebingen, 72074 Tuebingen, Germany.
Brenner E; Department of Dermatology, University of Tuebingen, 72076 Tuebingen, Germany.
Böhm K; Department of Dermatology, University of Tuebingen, 72076 Tuebingen, Germany.
Röcken M; Department of Dermatology, University of Tuebingen, 72076 Tuebingen, Germany.
Wieder T; Institute of Physiology I, Department of Vegetative and Clinical Physiology, University of Tuebingen, 72074 Tuebingen, Germany.
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Źródło:
Cells [Cells] 2022 Apr 30; Vol. 11 (9). Date of Electronic Publication: 2022 Apr 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Melanoma*/pathology
Senescence-Associated Secretory Phenotype*
Interferon-gamma/*metabolism
Tumor Necrosis Factor-alpha/*metabolism
CD8-Positive T-Lymphocytes/metabolism ; Cellular Senescence ; Humans
Czasopismo naukowe
Tytuł:
The mechanotransduction of MLO-Y4 cells is disrupted by the senescence-associated secretory phenotype of neighboring cells.
Autorzy:
Gardinier JD; Bone and Joint Center, Henry Ford Health System, Henry Ford Hospital, Detroit, Michigan, USA.
Chougule A; Bone and Joint Center, Henry Ford Health System, Henry Ford Hospital, Detroit, Michigan, USA.
Zhang C; Bone and Joint Center, Henry Ford Health System, Henry Ford Hospital, Detroit, Michigan, USA.
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Źródło:
Journal of cellular physiology [J Cell Physiol] 2022 Apr; Vol. 237 (4), pp. 2249-2257. Date of Electronic Publication: 2022 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Mechanotransduction, Cellular*
Animals ; Cell Line ; Interleukin-6/metabolism ; Mice ; Osteocytes/metabolism ; Senescence-Associated Secretory Phenotype
Czasopismo naukowe
Tytuł:
Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype.
Autorzy:
Ryu S; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea.; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea.
Jung M; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea.; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea.
Kim C; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea.; Catholic Institute for Visual Science, The Catholic University of Korea, Seoul, 06591, South Korea.
Kang H; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea.
Han S; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea.; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea.
Cha S; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea.; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea.
Jeong SM; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea.; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea.; Institute of Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea.
Lee EK; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea. .; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea. .; Institute of Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea. .
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Źródło:
Cell death & disease [Cell Death Dis] 2022 Apr 11; Vol. 13 (4), pp. 329. Date of Electronic Publication: 2022 Apr 11.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin-Secreting Cells*/metabolism
Senescence-Associated Secretory Phenotype*
ELAV-Like Protein 4/*metabolism
3' Untranslated Regions ; Animals ; Cellular Senescence/genetics ; Ligands ; Mice ; Mice, Knockout ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
Shear stress-induced cellular senescence blunts liver regeneration through Notch-sirtuin 1-P21/P16 axis.
Autorzy:
Duan JL; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
Ruan B; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.; Center of Clinical Aerospace Medicine & Department of Aviation Medicine, Fourth Military Medical University, Xi'an, China.
Song P; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
Fang ZQ; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
Yue ZS; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Ophthalmology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
Liu JJ; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
Dou GR; Department of Ophthalmology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
Han H; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.
Wang L; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
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Źródło:
Hepatology (Baltimore, Md.) [Hepatology] 2022 Mar; Vol. 75 (3), pp. 584-599. Date of Electronic Publication: 2021 Dec 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*/drug effects
Cellular Senescence*/physiology
Liver Regeneration*/drug effects
Liver Regeneration*/physiology
Receptors, Notch*/antagonists & inhibitors
Receptors, Notch*/metabolism
Signal Transduction/*drug effects
Sirtuin 1/*metabolism
Animals ; Gamma Secretase Inhibitors and Modulators/pharmacology ; Hepatectomy/methods ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Mice ; Nitric Oxide Synthase Type III/metabolism ; Senescence-Associated Secretory Phenotype/genetics
Czasopismo naukowe
Tytuł:
Cellular senescence-an aging hallmark in chronic obstructive pulmonary disease pathogenesis.
Autorzy:
Araya J; Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. Electronic address: .
Kuwano K; Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
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Źródło:
Respiratory investigation [Respir Investig] 2022 Jan; Vol. 60 (1), pp. 33-44. Date of Electronic Publication: 2021 Oct 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Pulmonary Disease, Chronic Obstructive*/etiology
Senescence-Associated Secretory Phenotype*
Aging ; Autophagy ; Cellular Senescence ; Humans ; Lung
Czasopismo naukowe
Tytuł:
A guide to senolytic intervention in neurodegenerative disease.
Autorzy:
Lee S; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.
Wang EY; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.
Steinberg AB; University of Wisconsin Department of Biochemistry, 433 Babcock Drive., Madison, WI, 53706, USA.
Walton CC; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA. Electronic address: .
Chinta SJ; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA; Touro University California, College of Pharmacy, 1310 Club Dr., Vallejo, CA, 94592, USA. Electronic address: .
Andersen JK; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA. Electronic address: .
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Źródło:
Mechanisms of ageing and development [Mech Ageing Dev] 2021 Dec; Vol. 200, pp. 111585. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Aging*/drug effects
Aging*/physiology
Cellular Senescence*/drug effects
Cellular Senescence*/physiology
Neurodegenerative Diseases*/drug therapy
Neurodegenerative Diseases*/metabolism
Senotherapeutics/*pharmacology
Animals ; Humans ; Mice ; Senescence-Associated Secretory Phenotype/drug effects
Czasopismo naukowe
Tytuł:
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions.
Autorzy:
Englund DA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Zhang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Aversa Z; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Electronic address: .
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Źródło:
Mechanisms of ageing and development [Mech Ageing Dev] 2021 Dec; Vol. 200, pp. 111595. Date of Electronic Publication: 2021 Nov 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cellular Senescence*/drug effects
Cellular Senescence*/physiology
Muscle, Skeletal*/drug effects
Muscle, Skeletal*/metabolism
Muscle, Skeletal*/physiopathology
Sarcopenia*/drug therapy
Sarcopenia*/metabolism
Sarcopenia*/physiopathology
Senotherapeutics/*pharmacology
Humans ; Senescence-Associated Secretory Phenotype/drug effects
Czasopismo naukowe
Tytuł:
The senescence-associated secretory phenotype: Fueling a wound that never heals.
Autorzy:
Pulido T; Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Velarde MC; Institute of Biology, College of Science, University of the Philippines Diliman, Quezon City, 1101, Philippines. Electronic address: .
Alimirah F; Buck Institute for Research on Aging, Novato, CA, 94945, USA. Electronic address: .
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Źródło:
Mechanisms of ageing and development [Mech Ageing Dev] 2021 Oct; Vol. 199, pp. 111561. Date of Electronic Publication: 2021 Aug 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Immunosenescence*
Neoplasms*/immunology
Neoplasms*/pathology
Neoplasms*/therapy
Senescence-Associated Secretory Phenotype*
Wounds and Injuries*/immunology
Wounds and Injuries*/pathology
Wounds and Injuries*/therapy
Cellular Senescence/physiology ; Humans ; Paracrine Communication ; Wound Healing
Czasopismo naukowe
Tytuł:
Senescence-associated secretory phenotype and its impact on oral immune homeostasis.
Autorzy:
Yue Z; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Nie L; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhao P; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Faculty of Dentistry, The University of Hong Kong, Sai Ying Pun, Hong Kong SAR, China.
Ji N; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Liao G; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Information Management, Department of Stomatology Informatics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wang Q; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
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Źródło:
Frontiers in immunology [Front Immunol] 2022 Oct 04; Vol. 13, pp. 1019313. Date of Electronic Publication: 2022 Oct 04 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*/genetics
Senescence-Associated Secretory Phenotype*
Cytokines/metabolism ; Homeostasis ; Peptide Hydrolases ; Lipids
Czasopismo naukowe
Tytuł:
Human MSC-Derived Exosomes Reduce Cellular Senescence in Renal Epithelial Cells.
Autorzy:
Liao CM; Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Luo T; Biochemistry and Tumor Biology Lab, Department of Gynecology and Obstetrics, Hannover Medical School, 30625 Hannover, Germany.
von der Ohe J; Biochemistry and Tumor Biology Lab, Department of Gynecology and Obstetrics, Hannover Medical School, 30625 Hannover, Germany.
de Juan Mora B; Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Schmitt R; Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Hass R; Biochemistry and Tumor Biology Lab, Department of Gynecology and Obstetrics, Hannover Medical School, 30625 Hannover, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 17; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 17.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Epithelial Cells/*cytology
Exosomes/*metabolism
Kidney/*cytology
Mesenchymal Stem Cells/*cytology
Animals ; Cells, Cultured ; Epithelial Cells/metabolism ; Exosomes/transplantation ; Humans ; Kidney/metabolism ; Male ; Mesenchymal Stem Cells/metabolism ; Mice, Inbred C57BL ; Senescence-Associated Secretory Phenotype
Czasopismo naukowe
Tytuł:
A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization.
Autorzy:
Zampetidis CP; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Galanos P; Genome Integrity Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark. Electronic address: .
Angelopoulou A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Zhu Y; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Polyzou A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Karamitros T; Unit of Bioinformatics and Applied Genomics, Department of Microbiology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Kotsinas A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Lagopati N; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Mourkioti I; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Mirzazadeh R; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden.
Polyzos A; Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Garnerone S; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden.
Mizi A; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Gusmao EG; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Sofiadis K; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Gál Z; Nucleolar Stress and Disease Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Larsen DH; Nucleolar Stress and Disease Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Pefani DE; Laboratories of Biology, Medical School, University of Patras, 26504 Rio, Greece.
Demaria M; University of Groningen (RUG), European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen (UMCG), 9713 AV Groningen, the Netherlands.
Tsirigos A; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA.
Crosetto N; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden.
Maya-Mendoza A; DNA Replication and Cancer Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Papaspyropoulos A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Evangelou K; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Bartek J; Genome Integrity Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden. Electronic address: .
Papantonis A; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany. Electronic address: .
Gorgoulis VG; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece; Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, M20 4GJ Manchester, UK; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece; Faculty of Health and Medical Sciences, University of Surrey, Surrey GU2 7YH, UK. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2021 Dec 02; Vol. 81 (23), pp. 4907-4923.e8. Date of Electronic Publication: 2021 Nov 17.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Chromosome Inversion*
Epithelial-Mesenchymal Transition*
Oncogenes*
Recombination, Genetic*
Chromosomes/*ultrastructure
Neoplasms/*genetics
Animals ; Bronchi/metabolism ; CRISPR-Cas Systems ; Cell Cycle ; Cell Transformation, Neoplastic ; Circadian Rhythm ; Computational Biology ; Epithelial Cells/metabolism ; Flow Cytometry ; Genomics ; Humans ; Karyotyping ; Mice ; Mice, SCID ; Neoplasms/metabolism ; Phenotype ; Protein Binding ; Protein Domains ; Senescence-Associated Secretory Phenotype
Czasopismo naukowe
Tytuł:
Senescent Cells in Cancer: Wanted or Unwanted Citizens.
Autorzy:
Niklander SE; Unidad de Patologia y Medicina Oral, Facultad de Odontologia, Universidad Andres Bello, Viña del Mar 2520000, Chile.
Lambert DW; Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, UK.; Healthy Lifespan Institute, University of Sheffield, Sheffield S10 2TN, UK.
Hunter KD; Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, UK.; Oral Biology and Pathology, University of Pretoria, Pretoria 0028, South Africa.
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Źródło:
Cells [Cells] 2021 Nov 26; Vol. 10 (12). Date of Electronic Publication: 2021 Nov 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cellular Senescence*
Neoplasms/*pathology
Animals ; Biomarkers, Tumor/metabolism ; Humans ; Models, Biological ; Senescence-Associated Secretory Phenotype ; Signal Transduction
Czasopismo naukowe
Tytuł:
Senescent tumor cells: an overlooked adversary in the battle against cancer.
Autorzy:
Park SS; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea.; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, 16499, Korea.; Inflamm-Aging Translational Research Center, Ajou University School of Medicine, Suwon, 16499, Korea.
Choi YW; Inflamm-Aging Translational Research Center, Ajou University School of Medicine, Suwon, 16499, Korea.; Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, 16499, Korea.
Kim JH; Inflamm-Aging Translational Research Center, Ajou University School of Medicine, Suwon, 16499, Korea.; Department of Pathology, Ajou University School of Medicine, Suwon, 16499, Korea.
Kim HS; Department of Molecular Medicine, Inha University College of Medicine, Incheon, 22212, Korea. .
Park TJ; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea. .; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, 16499, Korea. .; Inflamm-Aging Translational Research Center, Ajou University School of Medicine, Suwon, 16499, Korea. .
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Źródło:
Experimental & molecular medicine [Exp Mol Med] 2021 Dec; Vol. 53 (12), pp. 1834-1841. Date of Electronic Publication: 2021 Dec 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cellular Senescence*/genetics
Neoplasms/*metabolism
Disease Management ; Disease Susceptibility ; Drug Development ; Gene Expression Regulation ; Humans ; Neoplasms/etiology ; Neoplasms/pathology ; Neoplasms/therapy ; Organ Specificity/genetics ; Senescence-Associated Secretory Phenotype/genetics ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells.
Autorzy:
Voskamp C
Anderson LA
Koevoet WJ
Barnhoorn S
Mastroberardino PG
van Osch GJ
Narcisi R; Department of Orthopaedics and Sports Medicine, Erasmus MC, 3015 CN Rotterdam, the .
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Źródło:
European cells & materials [Eur Cell Mater] 2021 Nov 25; Vol. 42, pp. 401-414. Date of Electronic Publication: 2021 Nov 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mesenchymal Stem Cells*
Senescence-Associated Secretory Phenotype*
Cellular Senescence ; Energy Metabolism ; Gene Expression Regulation
Czasopismo naukowe
Tytuł:
Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls.
Autorzy:
Owens WA; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK; The James Cook University Hospital, Middlesbrough, UK.
Walaszczyk A; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.
Spyridopoulos I; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.
Dookun E; Atelerix Ltd, Newcastle upon Tyne, UK.
Richardson GD; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK. Electronic address: .
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Źródło:
Mechanisms of ageing and development [Mech Ageing Dev] 2021 Sep; Vol. 198, pp. 111540. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Aging*/immunology
Aging*/metabolism
Cardiovascular Diseases*/etiology
Cardiovascular Diseases*/metabolism
Cardiovascular Diseases*/therapy
Cellular Senescence*/drug effects
Cellular Senescence*/physiology
Apoptosis Regulatory Proteins/*metabolism
Senotherapeutics/*pharmacology
Humans ; Inflammation/metabolism ; Senescence-Associated Secretory Phenotype ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
The Cancer SENESCopedia: A delineation of cancer cell senescence.
Autorzy:
Jochems F; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Thijssen B; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
De Conti G; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Jansen R; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Pogacar Z; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Groot K; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Wang L; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Schepers A; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Wang C; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Jin H; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Beijersbergen RL; Division of Molecular Carcinogenesis, The NKI Robotics and Screening Center, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Leite de Oliveira R; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Wessels LFA; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands; Faculty of EEMCS, Delft University of Technology, Delft, the Netherlands. Electronic address: .
Bernards R; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2021 Jul 27; Vol. 36 (4), pp. 109441.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*/drug effects
Neoplasms/*pathology
Aniline Compounds/pharmacology ; Azepines/pharmacology ; Cell Line, Tumor ; Etoposide/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Neoplasms/genetics ; Pyrimidines/pharmacology ; Reproducibility of Results ; Senescence-Associated Secretory Phenotype/drug effects ; Senescence-Associated Secretory Phenotype/genetics ; Senotherapeutics/pharmacology ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł:
Targeting senescence as an anticancer therapy.
Autorzy:
Bousset L; MRC London Institute of Medical Sciences (LMS), UK.; Faculty of Medicine, Institute of Clinical Sciences (ICS), Imperial College London, UK.
Gil J; MRC London Institute of Medical Sciences (LMS), UK.; Faculty of Medicine, Institute of Clinical Sciences (ICS), Imperial College London, UK.
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Źródło:
Molecular oncology [Mol Oncol] 2022 Nov; Vol. 16 (21), pp. 3855-3880. Date of Electronic Publication: 2022 Sep 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cellular Senescence*
Neoplasms*/therapy
Humans ; Aging/physiology ; Antineoplastic Agents/therapeutic use
Czasopismo naukowe
Tytuł:
Senescence and the tumor-immune landscape: Implications for cancer immunotherapy.
Autorzy:
Chibaya L; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Snyder J; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Ruscetti M; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA; Immunology and Microbiology Program, University of Massachusetts Chan Medical School, Worcester, MA, USA; Cancer Center, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: .
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Źródło:
Seminars in cancer biology [Semin Cancer Biol] 2022 Nov; Vol. 86 (Pt 3), pp. 827-845. Date of Electronic Publication: 2022 Feb 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cellular Senescence*/genetics
Neoplasms*/pathology
Humans ; Phenotype ; Immunotherapy ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR.
Autorzy:
Ding F; Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
Lu L; Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
Wu C; Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
Pan X; Department of Structural Heart Disease, National Center for Cardiovascular Disease, China & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, Key Laboratory of Cardiovascular Appratus Innovation, Beijing 100037, P.R. China.
Liu B; Department of Cardiology, the Second Hospital of Jilin University, Changchun, Jilin 130041, P. R. China.
Zhang Y; Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
Wang Y; Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
Wu W; Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
Yan B; Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
Zhang Y; Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
Yu XY; Key Laboratory of Molecular Target & Clinical Pharmacology and the NMPA & State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong 511436, P. R. China.
Li Y; Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
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Źródło:
Theranostics [Theranostics] 2022 Oct 31; Vol. 12 (17), pp. 7550-7566. Date of Electronic Publication: 2022 Oct 31 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Heart Diseases*/genetics
Heart Diseases*/metabolism
RNA, Circular*/genetics
RNA, Circular*/metabolism
Cellular Senescence*/genetics
Cellular Senescence*/physiology
Myocytes, Cardiac*/metabolism
Myocytes, Cardiac*/physiology
Animals ; Humans ; Mice ; beta-Transducin Repeat-Containing Proteins/genetics ; beta-Transducin Repeat-Containing Proteins/metabolism ; RNA ; RNA, Messenger/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł:
Long-Term IGF1 Stimulation Leads to Cellular Senescence via Functional Interaction with the Thioredoxin-Interacting Protein, TXNIP.
Autorzy:
Nagaraj K; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Sarfstein R; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Laron Z; Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, Petah Tikva 49292, Israel.
Werner H; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
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Źródło:
Cells [Cells] 2022 Oct 17; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 17.
Typ publikacji:
Journal Article
MeSH Terms:
Carrier Proteins*/metabolism
Cellular Senescence*/drug effects
Cellular Senescence*/physiology
Insulin-Like Growth Factor I*/pharmacology
Insulin-Like Growth Factor I*/physiology
Laron Syndrome*/metabolism
Thioredoxins*/metabolism
Animals ; Mice ; Glucose/metabolism ; Growth Hormone/metabolism ; Mitochondrial Proteins/metabolism ; Humans ; Fibroblasts/drug effects ; 3T3-L1 Cells
Czasopismo naukowe

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