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Wyszukujesz frazę ""senescence"" wg kryterium: Temat


Starter badań:

Tytuł :
A common signature of cellular senescence; does it exist?
Autorzy :
Sikora E; Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland. Electronic address: .
Bielak-Zmijewska A; Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Mosieniak G; Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 Nov; Vol. 71, pp. 101458. Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging*/genetics
Cellular Senescence*
DNA Damage ; Fibroblasts ; Humans ; Signal Transduction
Czasopismo naukowe
Tytuł :
Muscle-specific programmed cell death 5 deletion attenuates cardiac aging.
Autorzy :
Naz A; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Zhang S; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
An L; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Song Z; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Zi Z; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Wu J; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Lai S; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Mazhar H; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Xu M; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Chen Y; Department of Immunology, School of Basic Medical Sciences, Peking University; NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China.
Zou Y; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
He L; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Zhu H; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China. Electronic address: .
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Źródło :
International journal of cardiology [Int J Cardiol] 2021 Dec 15; Vol. 345, pp. 98-104. Date of Electronic Publication: 2021 Oct 25.
Typ publikacji :
Journal Article
MeSH Terms :
Aging*/genetics
Cellular Senescence*
Animals ; Apoptosis ; Apoptosis Regulatory Proteins/genetics ; Mice ; Mitophagy ; Myocytes, Cardiac ; Neoplasm Proteins
Czasopismo naukowe
Tytuł :
Anagliptin prevented interleukin 1β (IL-1β)-induced cellular senescence in vascular smooth muscle cells through increasing the expression of sirtuin1 (SIRT1).
Autorzy :
Zhao J; Department of Cardiovascular Medicine, Xianyang Hospital of Yan'an University, Xianyang, Shaanxi, China.
He X; Department of Cardiovascular Medicine, Xianyang Hospital of Yan'an University, Xianyang, Shaanxi, China.
Zuo M; Department of Cardiovascular Medicine, Xianyang Hospital of Yan'an University, Xianyang, Shaanxi, China.
Li X; Department of Cardiovascular Medicine, Xianyang Hospital of Yan'an University, Xianyang, Shaanxi, China.
Sun Z; Department of Cardiology, The Fourth People's Hospital of Shaanxi, Xi'an, Shaanxi, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 3968-3977.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*/drug effects
Gene Expression Regulation*/drug effects
Interleukin-1beta/*toxicity
Muscle, Smooth, Vascular/*pathology
Myocytes, Smooth Muscle/*pathology
Pyrimidines/*pharmacology
Sirtuin 1/*genetics
Cell Survival/drug effects ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cytokines/metabolism ; Gene Silencing/drug effects ; Humans ; Inflammation Mediators/metabolism ; Protective Agents/pharmacology ; Pyrimidines/chemistry ; Sirtuin 1/metabolism
Czasopismo naukowe
Tytuł :
Autophagosome protects proximal tubular cells from aldosterone-induced senescence through improving oxidative stress.
Autorzy :
Cao JY; Department of Nephrology, Taizhou People's Hospital, The Fifth Affiliated Hospital of Nantong University, Taizhou, China.
Ling LL; Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Ni WJ; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Guo HL; Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yang M; Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
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Źródło :
Renal failure [Ren Fail] 2021 Dec; Vol. 43 (1), pp. 556-565.
Typ publikacji :
Journal Article
MeSH Terms :
Aldosterone/*pharmacology
Autophagosomes/*drug effects
Cellular Senescence/*drug effects
Kidney/*metabolism
Oxidative Stress/*drug effects
Aldosterone/administration & dosage ; Animals ; Cell Line ; Cells, Cultured ; Cellular Senescence/physiology ; Epithelial Cells/metabolism ; Humans ; Kidney/cytology ; Kidney/drug effects ; Male ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
In vitro expansion of human adipose-derived stem cells with delayed senescence through dual stage release of curcumin from mesoporous silica nanoparticles/electrospun nanofibers.
Autorzy :
Serati-Nouri H; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Rasoulpoor S; Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
Pourpirali R; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Sadeghi-Soureh S; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Esmaeilizadeh N; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Dadashpour M; Department of Biotechnology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Roshangar L; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Zarghami N; Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medicine, Faculty of Medicine, Istanbul Aydin University, Istanbul, Turkey. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 119947. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Drug Liberation*
Adipose Tissue/*cytology
Cell- and Tissue-Based Therapy/*methods
Curcumin/*administration & dosage
Mesenchymal Stem Cells/*drug effects
Nanofibers/*chemistry
Nanoparticles/*chemistry
Animals ; Cell Adhesion/drug effects ; Cell Proliferation ; Cells, Cultured ; Curcumin/pharmacology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gelatin/chemistry ; Humans ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/physiology ; Mice ; Polyesters/chemistry ; RNA, Messenger/biosynthesis ; Silicon Dioxide/chemistry ; Telomerase/biosynthesis
Czasopismo naukowe
Tytuł :
Noncanonical Wnt5a signaling regulates tendon stem/progenitor cells senescence.
Autorzy :
Chen M; Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Ding Jia Qiao, Nanjing, 210009, Jiangsu, People's Republic of China.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, 210009, Jiangsu, China.; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.; China Orthopedic Regenerative Medicine Group, Hangzhou, 310000, Zhejiang, China.
Li Y; China Orthopedic Regenerative Medicine Group, Hangzhou, 310000, Zhejiang, China.; Department of Geriatrics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.
Xiao L; Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Ding Jia Qiao, Nanjing, 210009, Jiangsu, People's Republic of China.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, 210009, Jiangsu, China.; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.; China Orthopedic Regenerative Medicine Group, Hangzhou, 310000, Zhejiang, China.
Dai G; Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Ding Jia Qiao, Nanjing, 210009, Jiangsu, People's Republic of China.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, 210009, Jiangsu, China.; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.; China Orthopedic Regenerative Medicine Group, Hangzhou, 310000, Zhejiang, China.
Lu P; Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Ding Jia Qiao, Nanjing, 210009, Jiangsu, People's Republic of China.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, 210009, Jiangsu, China.; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.; China Orthopedic Regenerative Medicine Group, Hangzhou, 310000, Zhejiang, China.
Rui Y; Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Ding Jia Qiao, Nanjing, 210009, Jiangsu, People's Republic of China. .; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, 210009, Jiangsu, China. .; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China. .; China Orthopedic Regenerative Medicine Group, Hangzhou, 310000, Zhejiang, China. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2021 Oct 18; Vol. 12 (1), pp. 544. Date of Electronic Publication: 2021 Oct 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Signal Transduction*
Stem Cells*/cytology
Wnt-5a Protein*/genetics
Tendons/*cytology
Animals ; Male ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
Senescent cells exacerbate chronic inflammation and contribute to periodontal disease progression in old mice.
Autorzy :
Aquino-Martinez R; Department of Medicine, Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN.
Eckhardt BA; Department of Medicine, Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN.
Rowsey JL; Department of Medicine, Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN.
Fraser DG; Department of Medicine, Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN.
Khosla S; Department of Medicine, Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN.
Farr JN; Department of Medicine, Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN.
Monroe DG; Department of Medicine, Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN.
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Źródło :
Journal of periodontology [J Periodontol] 2021 Oct; Vol. 92 (10), pp. 1483-1495. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cellular Senescence*
Periodontal Diseases*
Aging ; Animals ; Disease Progression ; Inflammation ; Mice ; Osteocytes
Czasopismo naukowe
Tytuł :
Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway.
Autorzy :
Zhang L; Department of Clinical Laboratory, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, PR China.; Department of Clinical Laboratory, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, PR China.
Liu M; Department of Clinical Laboratory, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, PR China.; Department of Clinical Laboratory, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, PR China.
Liu W; Department of Neurology, Wuhan No.1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Hu C; Department of Clinical Laboratory, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, PR China.
Li H; Geriatric Cardiology Department, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, PR China.
Deng J; Department of Clinical Laboratory, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, PR China.; Department of Clinical Laboratory, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, PR China.
Cao Q; The Centre for Transplantation and Renal Research, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, Australia.
Wang Y; The Centre for Transplantation and Renal Research, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, Australia.
Hu W; Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, PR China. .
Li Q; Department of Clinical Laboratory, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, PR China. .; Department of Clinical Laboratory, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, PR China. .
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Źródło :
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2021 Nov; Vol. 101 (11), pp. 1418-1426. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Endothelial Cells/*metabolism
Interleukin-17/*metabolism
Th17 Cells/*metabolism
Animals ; Arteries/physiology ; Interleukin-6/metabolism ; Male ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Retinoblastoma Protein/metabolism ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism ; Vascular Cell Adhesion Molecule-1/metabolism
Czasopismo naukowe
Tytuł :
p21 produces a bioactive secretome that places stressed cells under immunosurveillance.
Autorzy :
Sturmlechner I; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands.
Zhang C; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Sine CC; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
van Deursen EJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Jeganathan KB; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Hamada N; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Grasic J; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Friedman D; Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Stutchman JT; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Can I; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Hamada M; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Lim DY; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Lee JH; Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Ordog T; Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Laberge RM; Unity Biotechnology, South San Francisco, CA 94080, USA.
Shapiro V; Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Baker DJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Li H; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
van Deursen JM; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Oct 29; Vol. 374 (6567), pp. eabb3420. Date of Electronic Publication: 2021 Oct 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Immunologic Surveillance*
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Animals ; Cell Cycle Checkpoints ; Cell Line ; Chemokines, CXC/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Genes, ras ; Hepatocytes/immunology ; Hepatocytes/metabolism ; Humans ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; Mice, Transgenic ; Proto-Oncogene Proteins p21(ras)/metabolism ; Retinoblastoma Protein/metabolism ; Stress, Physiological ; T-Lymphocytes, Cytotoxic/immunology ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Prospective Selective Mechanism of Emerging Senolytic Agents Derived from Flavonoids.
Autorzy :
Wang Y; State Key Laboratory of Tea Plant Biology and Utilization, School of Tea & Food Science, Anhui Agricultural University, Hefei, Anhui 230036, People's Republic of China.
He Y; State Key Laboratory of Tea Plant Biology and Utilization, School of Tea & Food Science, Anhui Agricultural University, Hefei, Anhui 230036, People's Republic of China.
Rayman MP; Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom.
Zhang J; State Key Laboratory of Tea Plant Biology and Utilization, School of Tea & Food Science, Anhui Agricultural University, Hefei, Anhui 230036, People's Republic of China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Oct 27; Vol. 69 (42), pp. 12418-12423. Date of Electronic Publication: 2021 Oct 18.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Flavonoids*
Animals ; Apoptosis ; Humans ; Prospective Studies ; Quercetin ; Rats
Czasopismo naukowe
Tytuł :
Exposure to long-term evolution radiofrequency electromagnetic fields decreases neuroblastoma cell proliferation via Akt/mTOR-mediated cellular senescence.
Autorzy :
Kim JH; Department of Pharmacology, College of Medicine, Dankook University, Cheonan, South Korea.
Jeon S; Radio and Broadcasting Technology Laboratory, ETRI, Daejeon, South Korea.
Choi HD; Radio and Broadcasting Technology Laboratory, ETRI, Daejeon, South Korea.
Lee JH; Medical Laser Research Center, Dankook University, Cheonan, South Korea.
Bae JS; Medical Laser Research Center, Dankook University, Cheonan, South Korea.
Kim N; School of Electrical and Computer Engineering, Chungbuk National University, Cheongju, South Korea.
Kim HG; Department of Pharmacology, College of Medicine, Dankook University, Cheonan, South Korea.; NeuroVis Inc., Cheonan, Republic of Korea.
Kim KB; Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, South Korea.
Kim HR; Department of Pharmacology, College of Medicine, Dankook University, Cheonan, South Korea.
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Źródło :
Journal of toxicology and environmental health. Part A [J Toxicol Environ Health A] 2021 Oct 18; Vol. 84 (20), pp. 846-857. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation/*radiation effects
Cellular Senescence/*radiation effects
Electromagnetic Fields/*adverse effects
Neuroblastoma/*physiopathology
Radio Waves/*adverse effects
Cellular Senescence/genetics ; Humans ; Neuroblastoma/etiology ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Modulation of fracture healing by the transient accumulation of senescent cells.
Autorzy :
Saul D; Division of Endocrinology, Mayo Clinic, Rochester, United States.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, United States.; Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany.
Monroe DG; Division of Endocrinology, Mayo Clinic, Rochester, United States.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, United States.; Division of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, United States.
Rowsey JL; Division of Endocrinology, Mayo Clinic, Rochester, United States.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, United States.
Kosinsky RL; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, United States.
Vos SJ; Division of Endocrinology, Mayo Clinic, Rochester, United States.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, United States.
Doolittle ML; Division of Endocrinology, Mayo Clinic, Rochester, United States.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, United States.
Farr JN; Division of Endocrinology, Mayo Clinic, Rochester, United States.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, United States.; Division of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, United States.
Khosla S; Division of Endocrinology, Mayo Clinic, Rochester, United States.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, United States.; Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany.; Division of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, United States.
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Źródło :
ELife [Elife] 2021 Oct 07; Vol. 10. Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Fracture Healing*
Animals ; Biomarkers ; DNA Damage ; Female ; Humans ; Male ; Mice ; Models, Animal
Czasopismo naukowe
Tytuł :
Dissecting primary and secondary senescence to enable new senotherapeutic strategies.
Autorzy :
Admasu TD; SENS Research Foundation, Mountain View, CA, USA.
Rae M; SENS Research Foundation, Mountain View, CA, USA.
Stolzing A; SENS Research Foundation, Mountain View, CA, USA; Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 Sep; Vol. 70, pp. 101412. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging*
Cellular Senescence*
Humans ; Rejuvenation
Czasopismo naukowe
Tytuł :
Radiation-Induced Osteocyte Senescence Alters Bone Marrow Mesenchymal Stem Cell Differentiation Potential via Paracrine Signaling.
Autorzy :
Xu L; Department of Radiological Hygiene, Institute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai 200032, China.
Wang Y; Department of Radiological Hygiene, Institute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai 200032, China.
Wang J; Department of Radiological Hygiene, Institute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai 200032, China.
Zhai J; Department of Radiological Hygiene, Institute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai 200032, China.
Ren L; Department of Radiological Hygiene, Institute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai 200032, China.
Zhu G; Department of Radiological Hygiene, Institute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai 200032, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 28; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
Cellular Senescence*
Paracrine Communication*
Bone Resorption/*pathology
Gamma Rays/*adverse effects
Mesenchymal Stem Cells/*pathology
Osteocytes/*pathology
Animals ; Bone Resorption/etiology ; Bone Resorption/metabolism ; Male ; Mesenchymal Stem Cells/radiation effects ; Mice ; Mice, Inbred BALB C ; Osteocytes/radiation effects ; Osteogenesis
Czasopismo naukowe
Tytuł :
Cellular senescence and the senescence-associated secretory phenotype: Potential therapeutic targets for renal fibrosis.
Autorzy :
Wang WJ; School of Medicine, Nankai University, Tianjin 300071, China; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China.
Chen XM; School of Medicine, Nankai University, Tianjin 300071, China; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China. Electronic address: .
Cai GY; School of Medicine, Nankai University, Tianjin 300071, China; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China. Electronic address: .
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Źródło :
Experimental gerontology [Exp Gerontol] 2021 Aug; Vol. 151, pp. 111403. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cellular Senescence*
Kidney Diseases*/therapy
Extracellular Matrix ; Fibrosis ; Humans ; Phenotype ; Stem Cells
Czasopismo naukowe
Tytuł :
Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy.
Autorzy :
Kim SR; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.; Department of Nephrology and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Puranik AS; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.; Colton Center for Autoimmunity, Division of Rheumatology, New York University Langone Medical Center, New York, New York.
Jiang K; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Chen X; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.
Zhu XY; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Taylor I; FlowJo, BD Life Sciences, Ashland, Oregon.
Khodadadi-Jamayran A; Applied Bioinformatics Laboratories, New York University School of Medicine, New York, New York.
Lerman A; Department of Cardiology, Mayo Clinic, Rochester, Minnesota.
Hickson LJ; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Childs BG; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
Textor SC; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.
Niewold TB; Colton Center for Autoimmunity, Division of Rheumatology, New York University Langone Medical Center, New York, New York.
Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.
Lerman LO; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota .
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Źródło :
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2021 Aug; Vol. 32 (8), pp. 1987-2004. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence/*physiology
Cyclin-Dependent Kinase Inhibitor p16/*metabolism
Ischemia/*physiopathology
Kidney/*physiopathology
Renal Insufficiency, Chronic/*physiopathology
p21-Activated Kinases/*metabolism
Animals ; Apoptosis/drug effects ; Caspase 8/metabolism ; Cellular Senescence/drug effects ; Cellular Senescence/genetics ; Chronic Disease ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p19/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Dasatinib/pharmacology ; Disease Models, Animal ; Enzyme Activation/drug effects ; Epithelial Cells/physiology ; Epithelial-Mesenchymal Transition ; Gene Expression ; Heparin-binding EGF-like Growth Factor/genetics ; Humans ; Ischemia/etiology ; Kidney/blood supply ; Kidney/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Osteopontin/genetics ; Protein Kinase Inhibitors/pharmacology ; Renal Artery Obstruction/complications ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/pathology ; Sequence Analysis, RNA ; Single-Cell Analysis ; Tacrolimus/analogs & derivatives ; Tacrolimus/pharmacology ; Up-Regulation ; p21-Activated Kinases/genetics
Czasopismo naukowe
Tytuł :
Leukemia-Induced Cellular Senescence and Stemness Alterations in Mesenchymal Stem Cells Are Reversible upon Withdrawal of B-Cell Acute Lymphoblastic Leukemia Cells.
Autorzy :
Vanegas NP; Fisiología Celular y Molecular, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá D.C. 111321, Colombia.
Ruiz-Aparicio PF; Fisiología Celular y Molecular, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá D.C. 111321, Colombia.
Uribe GI; Servicio de Patología, Laboratorio de Hematología Especial y Citometría de Flujo, Fundación Hospital de la Misericordia, Bogotá D.C. 111071, Colombia.
Linares-Ballesteros A; Oncohematología Pediátrica, Fundación Hospital de la Misericordia, Universidad Nacional de Colombia, Bogotá D.C. 111071, Colombia.
Vernot JP; Fisiología Celular y Molecular, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá D.C. 111321, Colombia.; Facultad de Medicina, Instituto de Investigaciones Biomédicas, Universidad Nacional de Colombia, Bogotá D.C. 111321, Colombia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 29; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Tumor Microenvironment*
Mesenchymal Stem Cells/*pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*pathology
Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Hematopoietic Stem Cells/pathology ; Humans
Czasopismo naukowe
Tytuł :
Effects of IGFBP3 knockdown on human endometrial mesenchymal stromal cells stress-induced senescence.
Autorzy :
Ushakov RE; Institute of Cytology RAS, Tikhoretsky Ave 4, St. Petersburg, 194064, Russia.
Aksenov ND; Institute of Cytology RAS, Tikhoretsky Ave 4, St. Petersburg, 194064, Russia.
Pugovkina NA; Institute of Cytology RAS, Tikhoretsky Ave 4, St. Petersburg, 194064, Russia.
Burova EB; Institute of Cytology RAS, Tikhoretsky Ave 4, St. Petersburg, 194064, Russia. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Sep 17; Vol. 570, pp. 143-147. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Gene Knockdown Techniques*
Stress, Physiological*
Endometrium/*pathology
Insulin-Like Growth Factor Binding Protein 3/*metabolism
Mesenchymal Stem Cells/*metabolism
Cell Line ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Female ; Humans ; Retinoblastoma Protein/metabolism ; Tumor Suppressor Protein p53/metabolism ; Up-Regulation ; beta-Galactosidase/metabolism
Czasopismo naukowe
Tytuł :
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3.
Autorzy :
Tripathi U; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Nchioua R; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
Prata LGPL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.; Department of Physiology and Bioengineering, Mayo Clinic, Rochester, MN 55905, USA.
Gerdes EOW; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Giorgadze N; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Pirtskhalava T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Parker E; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN 47405, USA.
Xue A; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Espindola-Netto JM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Stenger S; Institute for Medical Microbiology and Hygiene, Ulm University Medical Center, Ulm 89081, Germany.
Robbins PD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Dickinson SL; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN 47405, USA.
Allison DB; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN 47405, USA.
Kirchhoff F; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
Sparrer KMJ; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.; Department of Physiology and Bioengineering, Mayo Clinic, Rochester, MN 55905, USA.
Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.; Department of Physiology and Bioengineering, Mayo Clinic, Rochester, MN 55905, USA.; Divisions of Geriatrics and Gerontology and General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
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Źródło :
Aging [Aging (Albany NY)] 2021 Sep 16; Vol. 13 (18), pp. 21838-21854. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
COVID-19/*virology
SARS-CoV-2/*pathogenicity
Toll-Like Receptor 3/*metabolism
Aging ; Animals ; Apoptosis ; COVID-19/drug therapy ; COVID-19/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Humans ; Inflammation ; Lung/metabolism ; Mice ; Phenotype ; Viral Proteins
Czasopismo naukowe

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