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Tytuł:
Atractylenolide III suppresses senescence-associated secretome via inhibiting cGAS/NF-κB pathway in hepatic stellate cells.
Autorzy:
Wu H; Institute of Biomedical Technology, Jiangsu Vocational College of Medicine, Yancheng, China.; School of Pharmacology, Jiangsu Vocational College of Medicine, Yancheng, China.
Wu L; Department of Pediatrics, Lujiang People's Hospital, Hefei, China.
Xiao L; School of Pharmacology, Jiangsu Vocational College of Medicine, Yancheng, China.
Gu Y; School of Pharmacology, Jiangsu Vocational College of Medicine, Yancheng, China.
Liu H; School of Pharmacology, Jiangsu Vocational College of Medicine, Yancheng, China.
Zhang L; Institute of Biomedical Technology, Jiangsu Vocational College of Medicine, Yancheng, China.; School of Pharmacology, Jiangsu Vocational College of Medicine, Yancheng, China.
Zhang M; School of Pharmacology, Jiangsu Vocational College of Medicine, Yancheng, China.
Qi L; School of Pharmacology, Jiangsu Vocational College of Medicine, Yancheng, China.
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Źródło:
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2023 Apr; Vol. 50 (4), pp. 316-324. Date of Electronic Publication: 2023 Jan 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatic Stellate Cells*
NF-kappa B*/metabolism
Humans ; Cellular Senescence ; Etoposide/pharmacology ; Liver Cirrhosis ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism ; Nucleotidyltransferases/pharmacology ; Secretome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An oral phenylacrylic acid derivative suppressed hepatic stellate cell activation and ameliorated liver fibrosis by blocking TGF-β1 signalling.
Autorzy:
Xue T; Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yue L; Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Zhu G; Institute of Respiratory Health, West China Hospital, Sichuan University, Chengdu, China.
Tan Z; Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Liu H; Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Gan C; Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Fan C; Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.; Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital.C.T.), Chengdu, China.
Su X; Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Xie Y; Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Ye T; Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2023 Mar; Vol. 43 (3), pp. 718-732. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transforming Growth Factor beta1*/genetics
Transforming Growth Factor beta1*/metabolism
Transforming Growth Factor beta1*/pharmacology
Hepatic Stellate Cells*/metabolism
Mice ; Animals ; Liver Cirrhosis/pathology ; Signal Transduction ; Liver/pathology ; Carbon Tetrachloride/adverse effects ; Carbon Tetrachloride/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Regulation of the macrophage-hepatic stellate cell interaction by targeting macrophage peroxisome proliferator-activated receptor gamma to prevent non-alcoholic steatohepatitis progression in mice.
Autorzy:
Ni XX; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; NHC Key Laboratory of Digestive Diseases; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ji PX; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; NHC Key Laboratory of Digestive Diseases; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Chen YX; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; NHC Key Laboratory of Digestive Diseases; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Li XY; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; NHC Key Laboratory of Digestive Diseases; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Sheng L; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; NHC Key Laboratory of Digestive Diseases; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Lian M; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; NHC Key Laboratory of Digestive Diseases; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Guo CJ; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; NHC Key Laboratory of Digestive Diseases; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Hua J; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; NHC Key Laboratory of Digestive Diseases; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2022 Dec; Vol. 42 (12), pp. 2696-2712. Date of Electronic Publication: 2022 Oct 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatic Stellate Cells*/metabolism
Non-alcoholic Fatty Liver Disease*/prevention & control
Non-alcoholic Fatty Liver Disease*/metabolism
Mice ; Animals ; PPAR gamma/metabolism ; Culture Media, Conditioned/metabolism ; Mice, Inbred C57BL ; Macrophages/metabolism ; Liver/metabolism ; Liver Cirrhosis/pathology ; Inflammation/pathology ; Methionine/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury.
Autorzy:
Du K; Department of Medicine, Duke University, Durham, NC, USA.
Oh SH; Department of Medicine, Duke University, Durham, NC, USA.
Dutta RK; Department of Medicine, Duke University, Durham, NC, USA.
Sun T; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.
Yang WH; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.
Chi JT; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.
Diehl AM; Department of Medicine, Duke University, Durham, NC, USA.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2021 Sep; Vol. 41 (9), pp. 2214-2227. Date of Electronic Publication: 2021 Jul 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Ferroptosis*
Hepatic Stellate Cells*/pathology
Animals ; Hepatocytes ; Liver/pathology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/pathology ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
Autorzy:
Zhao B; Department of Pathophysiology, Harbin Medical University, Harbin, China.
Li S; Department of Pathophysiology, Harbin Medical University, Harbin, China.
Guo Z; Department of Hepatobiliary and Pancreatic Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
Chen Z; Department of Infectious Diseases, General Hospital for the Head Office of Agricultural Cultivation of Heilongjiang, Harbin, China.
Zhang X; Department of Pathophysiology, Harbin Medical University, Harbin, China.
Xu C; Department of Pathophysiology, Harbin Medical University, Harbin, China.
Chen J; Department of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Wei C; Department of Pathophysiology, Harbin Medical University, Harbin, China.
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Źródło:
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2021 Mar; Vol. 48 (3), pp. 370-380. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatic Stellate Cells*
Transforming Growth Factor beta1*
Animals ; Aspartate Aminotransferases ; Fibrosis ; Liver ; Rats ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Immunophenotypic analysis of the distribution of hepatic macrophages, lymphocytes and hepatic stellate cells in the adult rat liver.
Autorzy:
Pervin M; Department of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Hasan I; Department of Anatomy and Histology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Kobir MA; Department of Anatomy and Histology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Akter L; Department of Anatomy and Histology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Karim MR; Department of Anatomy and Histology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.
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Źródło:
Anatomia, histologia, embryologia [Anat Histol Embryol] 2021 Jul; Vol. 50 (4), pp. 736-745. Date of Electronic Publication: 2021 Jun 15.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatic Stellate Cells*
Kupffer Cells*
Animals ; Immunohistochemistry ; Liver ; Lymphocytes ; Macrophages ; Rats ; Rats, Inbred F344
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
JAM-A is a multifaceted regulator in hepatic fibrogenesis, supporting LSEC integrity and stellate cell quiescence.
Autorzy:
Brozat JF; Department of Internal Medicine III, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
Brandt EF; Department of Internal Medicine III, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
Stark M; Department of Internal Medicine III, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
Fischer P; Department of Internal Medicine III, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
Wirtz TH; Department of Internal Medicine III, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
Flaßhove A; Department of Internal Medicine III, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
Rodenhausen AN; Department of Internal Medicine III, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
Vajen T; Cardiovascular Research Laboratory, Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Heinzmann ACA; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
Schmitz SM; Department of General, Visceral and Transplantation Surgery, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
Abu Jhaisha S; Department of Internal Medicine III, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
Röth AA; Department of General, Visceral and Transplantation Surgery, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
Koenen RR; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
Sahin H; Department of Internal Medicine III, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
Trautwein C; Department of Internal Medicine III, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
Berres ML; Department of Internal Medicine III, RWTH Aachen University Hospital, RWTH Aachen, Aachen, Germany.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2022 May; Vol. 42 (5), pp. 1185-1203. Date of Electronic Publication: 2022 Mar 11.
Typ publikacji:
Journal Article
MeSH Terms:
Junctional Adhesion Molecule A*/metabolism
Animals ; Endothelial Cells/metabolism ; Fibrosis ; Hedgehog Proteins/metabolism ; Hepatic Stellate Cells/metabolism ; Humans ; Liver/pathology ; Liver Cirrhosis/pathology ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mitochondria-targeted antioxidant mitoquinone deactivates human and rat hepatic stellate cells and reduces portal hypertension in cirrhotic rats.
Autorzy:
Vilaseca M; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.
García-Calderó H; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
Lafoz E; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.
Ruart M; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.
López-Sanjurjo CI; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
Murphy MP; MRC Mitochondrial Biology Unit, Cambridge, UK.
Deulofeu R; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.; Department of Biochemistry and Chromatography, Hospital Clinic de Barcelona, Barcelona, Spain.
Bosch J; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
Hernández-Gea V; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
Gracia-Sancho J; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
García-Pagán JC; Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2017 Jul; Vol. 37 (7), pp. 1002-1012. Date of Electronic Publication: 2017 Apr 27.
Typ publikacji:
Journal Article
MeSH Terms:
Antioxidants/*pharmacology
Hepatic Stellate Cells/*drug effects
Hypertension, Portal/*prevention & control
Liver Cirrhosis, Experimental/*drug therapy
Mitochondria, Liver/*drug effects
Organophosphorus Compounds/*pharmacology
Oxidative Stress/*drug effects
Ubiquinone/*analogs & derivatives
Animals ; Anti-Inflammatory Agents/pharmacology ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Humans ; Hypertension, Portal/etiology ; Hypertension, Portal/metabolism ; Hypertension, Portal/physiopathology ; Liver Cirrhosis, Experimental/complications ; Liver Cirrhosis, Experimental/metabolism ; Liver Cirrhosis, Experimental/physiopathology ; Male ; Mitochondria, Liver/metabolism ; Mitochondria, Liver/pathology ; Phenotype ; Portal Pressure/drug effects ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Time Factors ; Ubiquinone/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tribbles homolog 2 promotes hepatic fibrosis and hepatocarcinogenesis through phosphatase 1A-Mediated stabilization of yes-associated protein.
Autorzy:
Xiang D; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Zhu X; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Zhang Y; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Zou J; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Li J; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Kong L; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Zhang H; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2021 May; Vol. 41 (5), pp. 1131-1147. Date of Electronic Publication: 2021 Jan 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/pathology
Calcium-Calmodulin-Dependent Protein Kinases ; Hepatic Stellate Cells/pathology ; Humans ; Liver Cirrhosis/pathology ; Phosphoric Monoester Hydrolases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mechanisms of fibrosis in acute liver failure.
Autorzy:
He Y; Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institution of Hepatology, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi province, China.
Jin L; Institution of Hepatology, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi province, China.
Wang J; Institution of Hepatology, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi province, China.
Yan Z; Institution of Hepatology, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi province, China.; Department of Infectious Diseases, Second teaching hospital of ShanDong university, Jinan, Shandong province, China.
Chen T; Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institution of Hepatology, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi province, China.
Zhao Y; Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.; Institution of Hepatology, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi province, China.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2015 Jul; Vol. 35 (7), pp. 1877-85. Date of Electronic Publication: 2015 Jan 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatic Stellate Cells/*pathology
Hepatitis B/*complications
Liver/*pathology
Liver Cirrhosis/*diagnosis
Liver Failure, Acute/*diagnosis
Actins/genetics ; Actins/metabolism ; Animals ; Autophagy ; Biomarkers/blood ; Biopsy ; Cells, Cultured ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Collagen Type I, alpha 1 Chain ; Disease Progression ; Elasticity Imaging Techniques ; HMGB1 Protein/blood ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/virology ; Hepatitis B/diagnosis ; Humans ; Liver/metabolism ; Liver/virology ; Liver Cirrhosis/blood ; Liver Cirrhosis/genetics ; Liver Cirrhosis/pathology ; Liver Cirrhosis/virology ; Liver Failure, Acute/blood ; Liver Failure, Acute/genetics ; Liver Failure, Acute/pathology ; Liver Failure, Acute/virology ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Predictive Value of Tests ; Prospective Studies ; Rats ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways.
Autorzy:
Li J; Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
Li X
Xu W
Wang S
Hu Z
Zhang Q
Deng X
Wang J
Zhang J
Guo C
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2015 Apr; Vol. 35 (4), pp. 1222-33. Date of Electronic Publication: 2014 Aug 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemical and Drug Induced Liver Injury/*prevention & control
Hepatic Stellate Cells/*drug effects
Liver Cirrhosis, Experimental/*prevention & control
Luteolin/*pharmacology
Proto-Oncogene Proteins c-akt/*metabolism
Ribosomal Protein S6 Kinases, 70-kDa/*metabolism
Smad2 Protein/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Transforming Growth Factor beta1/*metabolism
Animals ; Apoptosis/drug effects ; Cell Line ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Chemical and Drug Induced Liver Injury/enzymology ; Chemical and Drug Induced Liver Injury/pathology ; Collagen/metabolism ; Cytoprotection ; Dose-Response Relationship, Drug ; Enzyme Activation ; G1 Phase Cell Cycle Checkpoints/drug effects ; Hepatic Stellate Cells/enzymology ; Hepatic Stellate Cells/pathology ; Liver Cirrhosis, Experimental/enzymology ; Liver Cirrhosis, Experimental/pathology ; Male ; Phosphorylation ; Rats, Sprague-Dawley ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Integration of miRNA-regulatory networks in hepatic stellate cells identifies TIMP3 as a key factor in chronic liver disease.
Autorzy:
Azar F; University Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, Rennes, France.
Courtet K; University Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, Rennes, France.; University Rennes, CNRS, IRISA (Institut de recherche en informatique et système aléatoire, Rennes, France.
Dekky B; University Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, Rennes, France.
Bonnier D; University Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, Rennes, France.
Dameron O; University Rennes, CNRS, IRISA (Institut de recherche en informatique et système aléatoire, Rennes, France.
Colige A; Laboratory of Connective Tissues Biology, GIGA-R, University of Liege, Sart Tilman, Belgium.
Legagneux V; University Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, Rennes, France.
Théret N; University Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, Rennes, France.; University Rennes, CNRS, IRISA (Institut de recherche en informatique et système aléatoire, Rennes, France.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2020 Aug; Vol. 40 (8), pp. 2021-2033. Date of Electronic Publication: 2020 May 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/genetics
MicroRNAs*/genetics
Hepatic Stellate Cells ; Humans ; Liver Cirrhosis/genetics ; Tissue Inhibitor of Metalloproteinase-3/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than ever.
Autorzy:
Carloni V; Department of Experimental and Clinical Medicine, Center for Research, Transfer and High Education, DENOthe, University of Florence, Florence, Italy.
Luong TV
Rombouts K
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2014 Jul; Vol. 34 (6), pp. 834-43. Date of Electronic Publication: 2014 Feb 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Carcinoma, Hepatocellular/*metabolism
Extracellular Matrix/*metabolism
Hepatic Stellate Cells/*metabolism
Liver Neoplasms/*metabolism
Animals ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Cell Communication ; Extracellular Matrix/pathology ; Hepatic Stellate Cells/pathology ; Humans ; Liver Cirrhosis/epidemiology ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Liver Neoplasms/epidemiology ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Prognosis ; Risk Factors ; Signal Transduction ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Increasing the effectiveness of tyrosine kinase inhibitor (TKI) in combination with a statin in reducing liver fibrosis.
Autorzy:
Mohammadalipour A; Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran.; Department of Clinical Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Hashemnia M; Department of Pathobiology, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
Goudarzi F; Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Ravan AP; Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran.
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Źródło:
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2019 Dec; Vol. 46 (12), pp. 1183-1193. Date of Electronic Publication: 2019 Aug 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Atorvastatin/*administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage
Liver Cirrhosis/*prevention & control
Protein Kinase Inhibitors/*administration & dosage
Pyrimidines/*administration & dosage
Animals ; Atorvastatin/pharmacology ; Carbon Tetrachloride ; Cells, Cultured ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Drug Synergism ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/physiology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Liver/drug effects ; Liver/pathology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/pathology ; Male ; Protein Kinase Inhibitors/pharmacology ; Pyrimidines/pharmacology ; Rats ; Rats, Wistar ; Treatment Outcome
Czasopismo naukowe
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Tytuł:
P311 modulates hepatic stellate cells migration.
Autorzy:
Guimarães EL; Liver Cell Biology Lab, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, 1090, Belgium.
Stradiot L
Mannaerts I
Schroyen B
van Grunsven LA
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2015 Apr; Vol. 35 (4), pp. 1253-64. Date of Electronic Publication: 2014 Oct 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Movement*/drug effects
Hepatic Stellate Cells/*metabolism
Liver/*metabolism
Liver Cirrhosis, Experimental/*metabolism
Nerve Tissue Proteins/*metabolism
Animals ; Becaplermin ; Cell Proliferation ; Cells, Cultured ; Chemokine CCL2/pharmacology ; Gene Expression Regulation ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/pathology ; Liver/drug effects ; Liver/pathology ; Liver Cirrhosis, Experimental/genetics ; Liver Cirrhosis, Experimental/pathology ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice, Inbred BALB C ; Nerve Tissue Proteins/genetics ; Oxidative Stress ; Proto-Oncogene Proteins c-sis/pharmacology ; RNA Interference ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Time Factors ; Transfection ; Transforming Growth Factor beta/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
K⁺-channel inhibition reduces portal perfusion pressure in fibrotic rats and fibrosis associated characteristics of hepatic stellate cells.
Autorzy:
Freise C; Department of Gastroenterology, Infectiology and Rheumatology, Charité - University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany.
Heldwein S
Erben U
Hoyer J
Köhler R
Jöhrens K
Patsenker E
Ruehl M
Seehofer D
Stickel F
Somasundaram R
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2015 Apr; Vol. 35 (4), pp. 1244-52. Date of Electronic Publication: 2014 Sep 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatic Stellate Cells/*drug effects
Intermediate-Conductance Calcium-Activated Potassium Channels/*antagonists & inhibitors
Liver/*drug effects
Liver Cirrhosis, Experimental/*drug therapy
Portal Pressure/*drug effects
Potassium Channel Blockers/*pharmacology
Pyrazoles/*pharmacology
Actins/genetics ; Actins/metabolism ; Animals ; Cell Cycle/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Dose-Response Relationship, Drug ; Gene Expression Regulation ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Intermediate-Conductance Calcium-Activated Potassium Channels/genetics ; Intermediate-Conductance Calcium-Activated Potassium Channels/metabolism ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis, Experimental/genetics ; Liver Cirrhosis, Experimental/metabolism ; Liver Cirrhosis, Experimental/pathology ; Liver Cirrhosis, Experimental/physiopathology ; Male ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Transfection ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factor beta1/pharmacology ; Vascular Resistance/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MicroRNA-155 attenuates activation of hepatic stellate cell by simultaneously preventing EMT process and ERK1 signalling pathway.
Autorzy:
Dai W; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
Zhao J
Tang N
Zeng X
Wu K
Ye C
Shi J
Lu C
Ning B
Zhang J
Lin Y
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2015 Apr; Vol. 35 (4), pp. 1234-43. Date of Electronic Publication: 2014 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*
Signal Transduction*
Hepatic Stellate Cells/*enzymology
Liver/*enzymology
Liver Cirrhosis/*enzymology
Liver Cirrhosis, Experimental/*enzymology
MicroRNAs/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
3' Untranslated Regions ; Animals ; Apoptosis ; Binding Sites ; Case-Control Studies ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation ; HEK293 Cells ; Hepatic Stellate Cells/pathology ; Humans ; Liver/pathology ; Liver Cirrhosis/genetics ; Liver Cirrhosis/pathology ; Liver Cirrhosis, Experimental/genetics ; Liver Cirrhosis, Experimental/pathology ; MicroRNAs/genetics ; Rats, Sprague-Dawley ; Receptor, Angiotensin, Type 1/genetics ; Receptor, Angiotensin, Type 1/metabolism ; Time Factors ; Transcription Factor 4 ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transfection
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Upregulation of matrilin-2 expression in murine hepatic stellate cells during liver injury has no effect on fibrosis formation and resolution.
Autorzy:
Hintermann E; Pharmazentrum Frankfurt / ZAFES, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Bayer M
Pfeilschifter JM
Deák F
Kiss I
Paulsson M
Christen U
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2015 Apr; Vol. 35 (4), pp. 1265-73. Date of Electronic Publication: 2014 Jun 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemical and Drug Induced Liver Injury/*metabolism
Hepatic Stellate Cells/*metabolism
Hepatitis, Autoimmune/*metabolism
Liver/*metabolism
Liver Cirrhosis, Experimental/*metabolism
Animals ; Apoptosis ; Cell Line ; Cell Movement ; Cell Proliferation ; Chemical and Drug Induced Liver Injury/genetics ; Chemical and Drug Induced Liver Injury/pathology ; Collagen Type I/metabolism ; Fibronectins/metabolism ; Hepatic Stellate Cells/pathology ; Hepatitis, Autoimmune/genetics ; Hepatitis, Autoimmune/pathology ; Humans ; Kinetics ; Liver/pathology ; Liver Cirrhosis, Experimental/genetics ; Liver Cirrhosis, Experimental/pathology ; Matrilin Proteins/deficiency ; Matrilin Proteins/genetics ; Matrilin Proteins/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Severity of Illness Index ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chronic moderate alcohol consumption relieves high-fat high-cholesterol diet-induced liver fibrosis in a rat model.
Autorzy:
Sun F; Department of Elderly Gastroenterology, The First Hospital of China Medical University, Shenyang, China.
Zhuang Z; Centre of Translational Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Zhang D; Department of Elderly Gastroenterology, The First Hospital of China Medical University, Shenyang, China.
Chen Y; Department of Elderly Gastroenterology, The First Hospital of China Medical University, Shenyang, China.
Liu S; Department of Elderly Gastroenterology, The First Hospital of China Medical University, Shenyang, China.
Gao N; Department of Elderly Gastroenterology, The First Hospital of China Medical University, Shenyang, China.
Shi J; Centre of Translational Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Wang B; Department of Elderly Gastroenterology, The First Hospital of China Medical University, Shenyang, China.
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Źródło:
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2018 Oct; Vol. 45 (10), pp. 1046-1055. Date of Electronic Publication: 2018 Jul 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alcohol Drinking*
Cholesterol, Dietary/*adverse effects
Ethanol/*pharmacology
Liver Cirrhosis/*chemically induced
Liver Cirrhosis/*drug therapy
Animals ; Body Weight/drug effects ; Disease Models, Animal ; Eating/drug effects ; Energy Metabolism/drug effects ; Ethanol/therapeutic use ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/pathology ; Kupffer Cells/drug effects ; Kupffer Cells/pathology ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Organ Size/drug effects ; Rats ; Rats, Sprague-Dawley ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
5-HT2A receptor antagonists inhibit hepatic stellate cell activation and facilitate apoptosis.
Autorzy:
Kim DC; Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Jun DW
Kwon YI
Lee KN
Lee HL
Lee OY
Yoon BC
Choi HS
Kim EK
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2013 Apr; Vol. 33 (4), pp. 535-43. Date of Electronic Publication: 2013 Jan 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*drug effects
Hepatic Stellate Cells/*drug effects
Receptor, Serotonin, 5-HT2A/*drug effects
Serotonin 5-HT2 Receptor Antagonists/*pharmacology
Actins/metabolism ; Animals ; Cell Line ; Cell Survival/drug effects ; Collagen Type I/metabolism ; Dose-Response Relationship, Drug ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Humans ; Ketanserin/pharmacology ; Liver Cirrhosis, Experimental/chemically induced ; Liver Cirrhosis, Experimental/drug therapy ; Liver Cirrhosis, Experimental/metabolism ; Liver Cirrhosis, Experimental/pathology ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Receptor, Serotonin, 5-HT2A/genetics ; Receptor, Serotonin, 5-HT2A/metabolism ; Ritanserin/pharmacology ; Smad2 Protein/metabolism ; Smad3 Protein/metabolism ; Succinates/pharmacology ; Thioacetamide ; Time Factors ; Transforming Growth Factor beta/metabolism ; Wound Healing/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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