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Tytuł:
METTL3 and METTL14-mediated N -methyladenosine modification of SREBF2-AS1 facilitates hepatocellular carcinoma progression and sorafenib resistance through DNA demethylation of SREBF2.
Autorzy:
Wu X; Department of Hepatobiliary Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, No. 18 Zhongshan Two Road, Baise, 533000, China.
Zeng M; Graduate College of Youjiang Medical University for Nationalities, Baise, China.
Wei Y; Graduate College of Youjiang Medical University for Nationalities, Baise, China.
Lu R; Graduate College of Youjiang Medical University for Nationalities, Baise, China.
Huang Z; Graduate College of Youjiang Medical University for Nationalities, Baise, China.
Huang L; Graduate College of Youjiang Medical University for Nationalities, Baise, China.
Huang Y; Graduate College of Youjiang Medical University for Nationalities, Baise, China.
Lu Y; Graduate College of Youjiang Medical University for Nationalities, Baise, China.
Li W; Department of Hepatobiliary Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, No. 18 Zhongshan Two Road, Baise, 533000, China.
Wei H; Clinical Pathological Diagnosis and Research Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Pu J; Department of Hepatobiliary Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, No. 18 Zhongshan Two Road, Baise, 533000, China. jian_.; Guangxi Clinical Medical Research Center of Hepatobiliary Diseases, Baise, China. jian_.
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 14; Vol. 14 (1), pp. 6155. Date of Electronic Publication: 2024 Mar 14.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
Liver Neoplasms*/drug therapy
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
MicroRNAs*/genetics
Sterol Regulatory Element Binding Protein 2*
Adenosine/*analogs & derivatives
Humans ; Sorafenib/pharmacology ; DNA Demethylation ; Cell Line, Tumor ; RNA-Binding Proteins/metabolism ; Mixed Function Oxygenases/metabolism ; Proto-Oncogene Proteins/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Adrenarche-accompanied rise of adrenal sex steroid precursors prevents NAFLD in Young Female rats by converting into active androgens and inactivating hepatic Srebf1 signaling.
Autorzy:
Li H; College of Life Science, Sichuan Agricultural University, Ya'an, 625014, China.
Liu Y; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.
Meng F; College of Life Science, Sichuan Agricultural University, Ya'an, 625014, China.
Chen J; College of Life Science, Sichuan Agricultural University, Ya'an, 625014, China.
Han X; College of Life Science, Sichuan Agricultural University, Ya'an, 625014, China. .
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Źródło:
BMC genomics [BMC Genomics] 2024 Feb 19; Vol. 25 (1), pp. 190. Date of Electronic Publication: 2024 Feb 19.
Typ publikacji:
Journal Article
MeSH Terms:
Adrenarche*
Non-alcoholic Fatty Liver Disease*/etiology
Non-alcoholic Fatty Liver Disease*/prevention & control
Non-alcoholic Fatty Liver Disease*/metabolism
Sterol Regulatory Element Binding Protein 1*/metabolism
Animals ; Child ; Female ; Humans ; Rats ; Androgens ; Liver/metabolism ; Steroids
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation.
Autorzy:
Miyata S; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
Kodaka M; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, 156-8502, Japan.
Kikuchi A; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, 156-8502, Japan.
Matsunaga Y; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, 156-8502, Japan.
Shoji K; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, 156-8502, Japan.
Kuan YC; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.; Department of Horticulture and Landscape Architecture, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan.
Iwase M; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
Takeda K; Department of Chemistry for Life Sciences and Agriculture, Tokyo University of Agriculture, Tokyo, 156-8502, Japan.
Katsuta R; Department of Chemistry for Life Sciences and Agriculture, Tokyo University of Agriculture, Tokyo, 156-8502, Japan.
Ishigami K; Department of Chemistry for Life Sciences and Agriculture, Tokyo University of Agriculture, Tokyo, 156-8502, Japan.
Matsumoto Y; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, 156-8502, Japan.
Suzuki T; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, 156-8502, Japan.
Yamamoto Y; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, 156-8502, Japan.
Sato R; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan. .
Inoue J; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, 156-8502, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2022 May 24; Vol. 12 (1), pp. 8715. Date of Electronic Publication: 2022 May 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
NF-E2-Related Factor 2*/metabolism
Sterol Regulatory Element Binding Proteins*/metabolism
CCAAT-Enhancer-Binding Proteins/metabolism ; Cholesterol/metabolism ; Fatty Acid Synthases/metabolism ; Humans ; Isothiocyanates/pharmacology ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; Sterol Regulatory Element Binding Protein 1/genetics ; Sterol Regulatory Element Binding Protein 1/metabolism ; Sterol Regulatory Element Binding Protein 2/metabolism ; Sulfoxides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis.
Autorzy:
Chandrasekaran P; UT Southwestern Medical Center Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Weiskirchen R; Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), Rheinisch-Westfälische Technische Hochschule (RWTH) University Hospital Aachen, D-52074 Aachen, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 16; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 16.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Fatty Liver*
Liver Neoplasms*
Sterol Regulatory Element Binding Protein 1*/genetics
Intracellular Signaling Peptides and Proteins*/genetics
Membrane Proteins*/genetics
Animals ; Humans ; Lipid Metabolism ; Lipogenesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Osthole Increases the Sensitivity of Liver Cancer to Sorafenib by Inhibiting Cholesterol Metabolism.
Autorzy:
Fan K; Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province, China.
Huang H; Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province, China.
Zhao Y; Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province, China.; Department of Pharmacy, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Xie T; Department of Neurosurgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu Province, China.
Zhu ZY; Department of Pharmacy, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Xie ML; Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province, China.
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Źródło:
Nutrition and cancer [Nutr Cancer] 2022; Vol. 74 (10), pp. 3640-3650. Date of Electronic Publication: 2022 Jun 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Liver Neoplasms*/pathology
Sterol Regulatory Element Binding Protein 2*/genetics
Sterol Regulatory Element Binding Protein 2*/metabolism
Animals ; Cholesterol/metabolism ; Coumarins ; Liver/metabolism ; Mice ; Sorafenib/pharmacology ; Sterol Regulatory Element Binding Protein 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Excess phosphate promotes SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway.
Autorzy:
Liu MH; Department of Clinical Laboratory, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, Jiangxi 341000, P.R. China.
Lin XL; Department of Pathology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou, Guangdong 516002, P.R. China.
Xiao LL; Department of Nursing, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, Jiangxi 341000, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2024 Mar; Vol. 29 (3). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:
Journal Article
MeSH Terms:
Hyperphosphatemia*
COVID-19*
Membrane Proteins*
Intracellular Signaling Peptides and Proteins*
Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Proprotein Convertase 9/metabolism ; Sterol Regulatory Element Binding Protein 2/genetics ; Sterol Regulatory Element Binding Protein 2/metabolism ; SARS-CoV-2/metabolism ; Phosphates ; Sterol Regulatory Element Binding Protein 1/metabolism ; Signal Transduction ; Inflammation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice.
Autorzy:
Gil TY; Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
Park J; Department of Science in Korean Medicine, College of Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Park YJ; Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
Kim HJ; Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
Cominguez DC; Department of Rehabilitative Medicine of Korean Medicine and Neuropsychiatry, College of Korean Medicine, Sangji University, Wonju, Gangwon 26339, Republic of Korea.
An HJ; Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2024 Feb; Vol. 29 (2). Date of Electronic Publication: 2023 Dec 22.
Typ publikacji:
Journal Article
MeSH Terms:
Diet, High-Fat*/adverse effects
Anti-Obesity Agents*/pharmacology
Mice ; Animals ; Sterol Regulatory Element Binding Protein 1/genetics ; Sterol Regulatory Element Binding Protein 1/metabolism ; AMP-Activated Protein Kinases/metabolism ; Peroxisome Proliferator-Activated Receptors ; Rhizome ; Plant Extracts/pharmacology ; Obesity/drug therapy ; Obesity/etiology ; Obesity/metabolism ; Body Weight ; Mice, Inbred C57BL ; Mice, Obese
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG.
Autorzy:
Chen J; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Zhou Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Liu Z; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Lu Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Jiang Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Cao K; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Zhou N; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Wang D; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Zhang C; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.; Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhou N; Department of Pathology, Sichuan Mianyang 404 Hospital, Sichuan 621000, China.
Shi K; Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Zhang L; Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
Zhou L; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Wang Z; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Zhang H; Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Tang K; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Ma J; Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Lv J; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Huang B; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Feb 16; Vol. 383 (6684), pp. eadi3332. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Lipogenesis*
Liver*/metabolism
Liver Glycogen*/metabolism
Non-alcoholic Fatty Liver Disease*/drug therapy
Non-alcoholic Fatty Liver Disease*/metabolism
Proprotein Convertases*/metabolism
Serine Endopeptidases*
Uridine Diphosphate Glucose*/administration & dosage
Uridine Diphosphate Glucose*/metabolism
Animals ; Humans ; Mice ; Carbon/metabolism ; Glucose/metabolism ; Hepatocytes/metabolism ; Sterol Regulatory Element Binding Protein 1/genetics ; Sterol Regulatory Element Binding Protein 1/metabolism ; Male ; Mice, Inbred C57BL ; HEK293 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Laminaria japonica Aresch-Derived Fucoidan Ameliorates Hyperlipidemia by Upregulating LXRs and Suppressing SREBPs.
Autorzy:
Zhang Y; Department of Endocrinology and Metabolism, Guiqian International General Hospital, Guiyang 550018, China.
Liu T; Institute of Lipid Metabolism and Atherosclerosis, Innovative Drug Research Centre, School of Pharmacy, Weifang Medical University, Weifang 261053, China.
Qu ZJ; Cardiology Department, Qingzhou People's Hospital, Weifang 262500, China.
Wang X; Institute of Lipid Metabolism and Atherosclerosis, Innovative Drug Research Centre, School of Pharmacy, Weifang Medical University, Weifang 261053, China.
Song WG; Shandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250014, China.
Guo SD; Institute of Lipid Metabolism and Atherosclerosis, Innovative Drug Research Centre, School of Pharmacy, Weifang Medical University, Weifang 261053, China.
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Źródło:
Cardiovascular therapeutics [Cardiovasc Ther] 2024 Feb 12; Vol. 2024, pp. 8649365. Date of Electronic Publication: 2024 Feb 12 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Hyperlipidemias*/drug therapy
Hyperlipidemias*/genetics
Hyperlipidemias*/metabolism
Cardiovascular Diseases*/metabolism
Edible Seaweeds*
Laminaria*
Polysaccharides*
Mice ; Animals ; Proprotein Convertase 9/metabolism ; Sterol Regulatory Element Binding Protein 1/metabolism ; Sterol Regulatory Element Binding Protein 1/pharmacology ; Mice, Inbred C57BL ; Liver ; Cholesterol/metabolism ; Cholesterol/pharmacology ; Lipids
SCR Organism:
kombu kelp
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Timosaponin A3 Induces Anti-Obesity and Anti-Diabetic Effects In Vitro and In Vivo.
Autorzy:
Park, Ji-Hyuk (AUTHOR)
Jee, Wona (AUTHOR)
Park, So-Mi (AUTHOR)
Park, Ye-Rin (AUTHOR)
Kim, Seok Woo (AUTHOR)
Bae, Hanbit (AUTHOR)
Chung, Won-Suk (AUTHOR)
Cho, Jae-Heung (AUTHOR)
Kim, Hyungsuk (AUTHOR)
Song, Mi-Yeon (AUTHOR)
Jang, Hyeung-Jin (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 5, p2914. 16p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic.
Autorzy:
Jin Q; Department of Cardiovascular Medicine, Hengyang Medical School, The Changsha central Affiliated Hospital, University of South China, Changsha, Hunan, 410004, China.; Department of Cardiovascular Medicine, The Third Xiangya Hospital of Central South University, Changsha, Hunan Province, 410013, China.
Zhang C; Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chen R; Department of Cardiovascular Medicine, Hengyang Medical School, The Changsha central Affiliated Hospital, University of South China, Changsha, Hunan, 410004, China.
Jiang L; Department of Cardiovascular Medicine, Hengyang Medical School, The Changsha central Affiliated Hospital, University of South China, Changsha, Hunan, 410004, China.
Li H; Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, 410000, China.
Wu P; Department of Cardiovascular Medicine, Hengyang Medical School, The Changsha central Affiliated Hospital, University of South China, Changsha, Hunan, 410004, China. .
Li L; Department of Cardiovascular Medicine, Hengyang Medical School, The Changsha central Affiliated Hospital, University of South China, Changsha, Hunan, 410004, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Apr 15; Vol. 22 (1), pp. 352. Date of Electronic Publication: 2024 Apr 15.
Typ publikacji:
Journal Article
MeSH Terms:
HMGB1 Protein*/metabolism
Gastrointestinal Microbiome*
Atherosclerosis*/pathology
Methylamines*
Mice ; Animals ; Proprotein Convertase 9 ; Quinic Acid ; Sterol Regulatory Element Binding Protein 1/metabolism ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Lipid Metabolism ; Mice, Knockout, ApoE ; Inflammation ; Cholesterol ; Apolipoproteins E/metabolism ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The blockade of the TGF-β pathway alleviates abnormal glucose and lipid metabolism of lipodystrophy not obesity.
Autorzy:
Xu WD; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangdong Pharmaceutical University, Guangzhou, China.; Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, China.
Lai SZ; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangdong Pharmaceutical University, Guangzhou, China.; Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, China.
Zhao J; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangdong Pharmaceutical University, Guangzhou, China.; Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, China.
Wei SJ; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangdong Pharmaceutical University, Guangzhou, China.; Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, China.
Fang XY; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangdong Pharmaceutical University, Guangzhou, China.; Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, China.
Liu YY; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangdong Pharmaceutical University, Guangzhou, China.; Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, China.
Rong XL; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangdong Pharmaceutical University, Guangzhou, China.; Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, China.
Guo J; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangdong Pharmaceutical University, Guangzhou, China.; Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, China.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2024 Feb; Vol. 12 (1), pp. e1160.
Typ publikacji:
Journal Article
MeSH Terms:
Lipid Metabolism*
Lipodystrophy*/drug therapy
Mice ; Animals ; Transforming Growth Factor beta/metabolism ; Sterol Regulatory Element Binding Protein 1/metabolism ; Glycerol ; Obesity/drug therapy ; Obesity/metabolism ; Glucose/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses.
Autorzy:
Sun HY; Department of Biomedical Engineering, College of Biology, Hunan University, Changsha, China.; Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, China.; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chen TY; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Tan YC; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wang CH; Division of Gastroenterology, Tainan Municipal Hospital, Tainan, Taiwan.
Young KC; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. .; Institute of Basic Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. .; Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan. .
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Źródło:
Communications biology [Commun Biol] 2021 May 12; Vol. 4 (1), pp. 564. Date of Electronic Publication: 2021 May 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Clusterin/*metabolism
Lipid Metabolism/*physiology
Sterol O-Acyltransferase/*metabolism
Adult ; Aged ; Aged, 80 and over ; Animals ; Cholesterol/metabolism ; Cholesterol Esters/metabolism ; Clusterin/physiology ; Esterification ; Fatty Liver/metabolism ; Female ; Hepatitis C, Chronic/metabolism ; Humans ; Hypercholesterolemia/metabolism ; Lipid Droplets/metabolism ; Lipids/physiology ; Liver/metabolism ; Liver/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/physiopathology ; Sterol O-Acyltransferase/physiology ; Sterol O-Acyltransferase 2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The effect of simvastatin on gene expression of low-density lipoprotein receptor, sterol regulatory element-binding proteins, stearoyl-CoA desaturase 1 mRNA in rat hepatic tissues.
Autorzy:
Nezhadebrahimi A; Department of Biochemistry and Biophysics, Student Research Center, Metabolic Disorders Research Center, Gorgan Faculty of Medicine, Golestan University Medical Sciences, Gorgan, Iran.; Department of Physiology, Neuroscience Research Center, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Sepehri H; Department of Physiology, Neuroscience Research Center, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Jahanshahi M; Neuroscience Research Center, Department of Anatomy, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Marjani M; Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, North Cyprus, Turkey.
Marjani A; Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University Medical Sciences, Gorgan, Iran.
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Źródło:
Archives of physiology and biochemistry [Arch Physiol Biochem] 2022 Oct; Vol. 128 (5), pp. 1383-1390. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji:
Journal Article
MeSH Terms:
Stearoyl-CoA Desaturase*/genetics
Stearoyl-CoA Desaturase*/metabolism
Stearoyl-CoA Desaturase*/pharmacology
Sterol Regulatory Element Binding Proteins*/genetics
Sterol Regulatory Element Binding Proteins*/metabolism
Sterol Regulatory Element Binding Proteins*/pharmacology
Actins/genetics ; Actins/metabolism ; Actins/pharmacology ; Animals ; Cholesterol ; Gene Expression ; Glucose/metabolism ; Lipoproteins, LDL/genetics ; Lipoproteins, LDL/metabolism ; Liver/metabolism ; Male ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Simvastatin/pharmacology ; Triglycerides
Czasopismo naukowe
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Tytuł:
Alpha-Mangosteen lessens high-fat/high-glucose diet and low-dose streptozotocin induced-hepatic manifestations in the insulin resistance rat model.
Autorzy:
Soetikno V; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Andini P; Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Iskandar M; Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Matheos CC; Undergraduate Program in Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Herdiman JA; Undergraduate Program in Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Kyle IK; Undergraduate Program in Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Suma MNI; Undergraduate Program in Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Louisa M; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Estuningtyas A; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2023 Dec; Vol. 61 (1), pp. 241-248.
Typ publikacji:
Journal Article
MeSH Terms:
Garcinia mangostana*/metabolism
Insulin Resistance*
Fatty Liver*
Rats ; Male ; Animals ; Sterol Regulatory Element Binding Protein 1/metabolism ; Sterol Regulatory Element Binding Protein 1/pharmacology ; Streptozocin/pharmacology ; AMP-Activated Protein Kinases/metabolism ; Glucose/metabolism ; Rats, Sprague-Dawley ; Liver ; Diet, High-Fat/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PI3K/AKT/SERBP-1 pathway regulates Alisma orientalis beverage treatment of atherosclerosis in APOE high-fat diet mice.
Autorzy:
Liu R; Key Laboratory of Integrative Biomedicine for Brain Diseases, School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.; National Famous Chinese Medicine Expert Inheritance Studio (Meng Jingchun), School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.; Laboratory of Febrile Diseases, School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Sun Y; Key Laboratory of Integrative Biomedicine for Brain Diseases, School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.; National Famous Chinese Medicine Expert Inheritance Studio (Meng Jingchun), School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Di D; Key Laboratory of Integrative Biomedicine for Brain Diseases, School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.; National Famous Chinese Medicine Expert Inheritance Studio (Meng Jingchun), School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Zhang X; Sheyang Hospital of Traditional Chinese Medicine, Yancheng, People's Republic of China.
Zhu B; Key Laboratory of Integrative Biomedicine for Brain Diseases, School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.; National Famous Chinese Medicine Expert Inheritance Studio (Meng Jingchun), School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Wu H; Key Laboratory of Integrative Biomedicine for Brain Diseases, School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.; National Famous Chinese Medicine Expert Inheritance Studio (Meng Jingchun), School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2023 Dec; Vol. 61 (1), pp. 473-487.
Typ publikacji:
Journal Article
MeSH Terms:
Alisma*/metabolism
Atherosclerosis*/drug therapy
Plaque, Atherosclerotic*/drug therapy
Animals ; Mice ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Sterol Regulatory Element Binding Protein 1/metabolism ; Sterol Regulatory Element Binding Protein 1/pharmacology ; Signal Transduction ; Diet, High-Fat/adverse effects ; Lipids ; Apolipoproteins E/genetics ; Apolipoproteins E/pharmacology ; Apolipoproteins E/therapeutic use ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Carbon dioxide regulates cholesterol levels through SREBP2.
Autorzy:
Bolshette N; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Ezagouri S; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Dandavate V; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Karavaeva I; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Golik M; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Wang H; The Sam & Ann Barshop Institute for Longevity & Aging Studies, University of Texas Health Science Center, San Antonio, Texas, United States of America.
Espenshade PJ; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Osborne TF; Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, and Medicine in the Division of Endocrinology, Diabetes and Metabolism of the Johns Hopkins University School of Medicine, Petersburg, Florida, United States of America.
Han X; The Sam & Ann Barshop Institute for Longevity & Aging Studies, University of Texas Health Science Center, San Antonio, Texas, United States of America.
Asher G; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
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Źródło:
PLoS biology [PLoS Biol] 2023 Nov 15; Vol. 21 (11), pp. e3002367. Date of Electronic Publication: 2023 Nov 15 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Carbon Dioxide*
Cholesterol*/metabolism
Animals ; Signal Transduction ; Sterol Regulatory Element Binding Protein 2/genetics ; Sterol Regulatory Element Binding Protein 2/metabolism ; Mammals/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cornelian Cherry (Cornus mas L.) Fruit Extract Lowers SREBP-1c and C/EBPα in Liver and Alters Various PPAR-α, PPAR-γ, LXR-α Target Genes in Cholesterol-Rich Diet Rabbit Model.
Autorzy:
Danielewski, Maciej (AUTHOR)
Rapak, Andrzej (AUTHOR)
Kruszyńska, Angelika (AUTHOR)
Małodobra-Mazur, Małgorzata (AUTHOR)
Oleszkiewicz, Paweł (AUTHOR)
Dzimira, Stanisław (AUTHOR)
Kucharska, Alicja Z. (AUTHOR)
Słupski, Wojciech (AUTHOR)
Matuszewska, Agnieszka (AUTHOR)
Nowak, Beata (AUTHOR)
Szeląg, Adam (AUTHOR)
Piórecki, Narcyz (AUTHOR)
Zaleska-Dorobisz, Urszula (AUTHOR)
Sozański, Tomasz (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 2, p1199. 26p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 11784

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