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Wyszukujesz frazę ""tacrine"" wg kryterium: Temat


Tytuł:
Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease.
Autorzy:
Makhaeva GF; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.
Kovaleva NV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.
Rudakova EV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.
Boltneva NP; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.
Grishchenko MV; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Lushchekina SV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.; Emanuel Institute of Biochemical Physics Russian Academy of Sciences, Moscow 119334, Russia.
Astakhova TY; Emanuel Institute of Biochemical Physics Russian Academy of Sciences, Moscow 119334, Russia.
Serebryakova OG; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.
Timokhina EN; Emanuel Institute of Biochemical Physics Russian Academy of Sciences, Moscow 119334, Russia.
Zhilina EF; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Shchegolkov EV; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Ulitko MV; Institute of Natural Sciences and Mathematics of the Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620083, Russia.
Radchenko EV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.; Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia.
Palyulin VA; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.; Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia.
Burgart YV; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Saloutin VI; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Bachurin SO; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.
Richardson RJ; Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.; Center of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.; Michigan Institute for Computational Discovery and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 24; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Tacrine*/pharmacology
Tacrine*/chemistry
Animals ; Mice ; Acetylcholinesterase/metabolism ; Amyloid beta-Peptides/metabolism ; Antioxidants/pharmacology ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemistry ; Molecular Docking Simulation ; Salicylamides ; Structure-Activity Relationship ; Salicylic Acid/chemistry
Czasopismo naukowe
Tytuł:
Design, synthesis and biological evaluation of novel N -phosphorylated and O -phosphorylated tacrine derivatives as potential drugs against Alzheimer's disease.
Autorzy:
Przybyłowska M; Department of Organic Chemistry, Gdansk University of Technology, Gdansk, Poland.
Dzierzbicka K; Department of Organic Chemistry, Gdansk University of Technology, Gdansk, Poland.
Kowalski S; Department of Pharmaceutical Pathophysiology, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.
Demkowicz S; Department of Organic Chemistry, Gdansk University of Technology, Gdansk, Poland.
Daśko M; Department of Inorganic Chemistry, Gdansk University of Technology, Gdansk, Poland.
Inkielewicz-Stepniak I; Department of Pharmaceutical Pathophysiology, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1012-1022.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Tacrine*/chemistry
Acetylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemistry ; Humans ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Design, synthesis and evaluation of OA-tacrine hybrids as cholinesterase inhibitors with low neurotoxicity and hepatotoxicity against Alzheimer's disease.
Autorzy:
Yang H; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co., Ltd, Jiangsu, Lianyungang, China.; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, China.
Jia H; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, China.
Deng M; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, China.
Zhang K; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, China.
Liu Y; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, China.
Liu Y; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, China.
Cheng M; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, China.
Xiao W; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co., Ltd, Jiangsu, Lianyungang, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2192439.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Chemical and Drug Induced Liver Injury*
Humans ; Tacrine/pharmacology ; Cholinesterase Inhibitors/pharmacology ; Acetylcholinesterase/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Synthesis, biological evaluation, and computational studies of N-benzyl pyridinium–curcumin derivatives as potent AChE inhibitors with antioxidant activity.
Autorzy:
Al-Rifai, Nafisah M. (AUTHOR)
Al-Khalileh, Nemeh M. (AUTHOR)
Zahra, Jalal A. (AUTHOR)
El-Barghouthi, Musa I. (AUTHOR)
Darras, Fouad H. (AUTHOR)
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Źródło:
Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p1-12. 12p.
Czasopismo naukowe
Tytuł:
Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers.
Autorzy:
Vaaland IC; Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.
López Ó; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
Puerta A; BioLab, Instituto Universitario de Bio-Orgánica 'Antonio González' (IUBO-AG), Universidad de La Laguna, c/Astrofísico Francisco Sánchez, La Laguna, Spain.
Fernandes MX; BioLab, Instituto Universitario de Bio-Orgánica 'Antonio González' (IUBO-AG), Universidad de La Laguna, c/Astrofísico Francisco Sánchez, La Laguna, Spain.
Padrón JM; BioLab, Instituto Universitario de Bio-Orgánica 'Antonio González' (IUBO-AG), Universidad de La Laguna, c/Astrofísico Francisco Sánchez, La Laguna, Spain.
Fernández-Bolaños JG; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
Sydnes MO; Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.
Lindbäck E; Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 349-360.
Typ publikacji:
Journal Article
MeSH Terms:
Butyrylcholinesterase*
Acetylcholinesterase*
Humans ; Tacrine/pharmacology ; Alkynes
Czasopismo naukowe
Tytuł:
The Proof-of-Concept of MBA121, a Tacrine-Ferulic Acid Hybrid, for Alzheimer's Disease Therapy.
Autorzy:
Rodríguez-Ruiz ER; Neurovascular Research Group, Instituto Cajal (CSIC), Ave. Doctor Arce 37, 28002 Madrid, Spain.
Herrero-Labrador R; Neurovascular Research Group, Instituto Cajal (CSIC), Ave. Doctor Arce 37, 28002 Madrid, Spain.
Fernández-Fernández AP; Neurovascular Research Group, Instituto Cajal (CSIC), Ave. Doctor Arce 37, 28002 Madrid, Spain.
Serrano-Masa J; Neurovascular Research Group, Instituto Cajal (CSIC), Ave. Doctor Arce 37, 28002 Madrid, Spain.
Martínez-Montero JA; Neurovascular Research Group, Instituto Cajal (CSIC), Ave. Doctor Arce 37, 28002 Madrid, Spain.
González-Nieto D; Experimental Neurology Unit, Center for Biomedical Technology (CTB), Universidad Politécnica de Madrid, Campus de Montegancedo S/N, Pozuelo de Alarcón, 28223 Madrid, Spain.
Hana-Vaish M; UT Southwestern Medical Center, Department of Neurosurgery, School of Medicine, Baylor College of Medicine, Rice University, Houston, TX 77005, USA.
Benchekroun M; Laboratoire de Recherches Intégratives en Neurosciences et Psychologie Cognitive de Besançon, Groupe Chimie Médicinale, Université de Franche-Comté, F-25000 Besançon, France.
Ismaili L; Laboratoire de Recherches Intégratives en Neurosciences et Psychologie Cognitive de Besançon, Groupe Chimie Médicinale, Université de Franche-Comté, F-25000 Besançon, France.
Marco-Contelles J; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), C/Juan de la Cierva, 3, 28006 Madrid, Spain.; Center for Biomedical Network Research on Rare Diseases (CIBERER), CIBER, ISCIII, 28029 Madrid, Spain.
Martínez-Murillo R; Neurovascular Research Group, Instituto Cajal (CSIC), Ave. Doctor Arce 37, 28002 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 31; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 31.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/psychology
Male ; Mice ; Humans ; Animals ; Tacrine/pharmacology ; Tacrine/therapeutic use ; Butyrylcholinesterase ; Hydrogen Peroxide/therapeutic use ; Amyloid beta-Peptides ; Mice, Transgenic ; Disease Models, Animal ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł:
Design, Synthesis and Bioactivity Evaluation of Coumarin-BMT Hybrids as New Acetylcholinesterase Inhibitors.
Autorzy:
Zeng F; East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration, College of Forestry, Jiangxi Agricultural University, Nanchang 330045, China.; Jiangxi Academy of Forestry, Nanchang 330032, China.
Lu T; East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration, College of Forestry, Jiangxi Agricultural University, Nanchang 330045, China.
Wang J; Key Laboratory of Chemical Utilization of Plant Resources of Nanchang, College of Chemistry and Materials, Jiangxi Agricultural University, Nanchang 330045, China.
Nie X; Key Laboratory of Chemical Utilization of Plant Resources of Nanchang, College of Chemistry and Materials, Jiangxi Agricultural University, Nanchang 330045, China.
Xiong W; Key Laboratory of Chemical Utilization of Plant Resources of Nanchang, College of Chemistry and Materials, Jiangxi Agricultural University, Nanchang 330045, China.
Yin Z; East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration, College of Forestry, Jiangxi Agricultural University, Nanchang 330045, China.; Jiangxi Key Laboratory of Natural Products and Functional Food, Jiangxi Agricultural University, Nanchang 330045, China.
Peng D; East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration, College of Forestry, Jiangxi Agricultural University, Nanchang 330045, China.; Key Laboratory of Chemical Utilization of Plant Resources of Nanchang, College of Chemistry and Materials, Jiangxi Agricultural University, Nanchang 330045, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Mar 26; Vol. 27 (7). Date of Electronic Publication: 2022 Mar 26.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Tacrine*/chemistry
Tacrine*/pharmacology
Acetylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemistry ; Coumarins/chemistry ; Coumarins/pharmacology ; Molecular Docking Simulation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase.
Autorzy:
Evangelista TCS; Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.; Department of Organic Chemistry, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
López Ó; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
Ferreira SB; Department of Organic Chemistry, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Fernández-Bolaños JG; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
Sydnes MO; Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.
Lindbäck E; Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1659-1664.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Development*
Acetylcholinesterase/*metabolism
Cholinesterase Inhibitors/*pharmacology
Tacrine/*pharmacology
Animals ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Electrophorus ; Molecular Structure ; Structure-Activity Relationship ; Tacrine/chemical synthesis ; Tacrine/chemistry
Czasopismo naukowe
Tytuł:
Inhibition of Acetylcholinesterase by Novel Lupinine Derivatives.
Autorzy:
Schepetkin, Igor A. (AUTHOR)
Nurmaganbetov, Zhangeldy S. (AUTHOR)
Fazylov, Serik D. (AUTHOR)
Nurkenov, Oralgazy A. (AUTHOR)
Khlebnikov, Andrei I. (AUTHOR)
Seilkhanov, Tulegen M. (AUTHOR)
Kishkentaeva, Anarkul S. (AUTHOR)
Shults, Elvira E. (AUTHOR)
Quinn, Mark T. (AUTHOR)
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Źródło:
Molecules. Apr2023, Vol. 28 Issue 8, p3357. 15p.
Czasopismo naukowe
Tytuł:
Tacrine-Based Hybrids: Past, Present, and Future.
Autorzy:
Bubley A; Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.
Erofeev A; Department of Materials Science of Semiconductors and Dielectrics, National University of Science and Technology (MISIS), Leninskiy Prospect 4, Moscow 119049, Russia.
Gorelkin P; Department of Materials Science of Semiconductors and Dielectrics, National University of Science and Technology (MISIS), Leninskiy Prospect 4, Moscow 119049, Russia.
Beloglazkina E; Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.
Majouga A; Department of Materials Science of Semiconductors and Dielectrics, National University of Science and Technology (MISIS), Leninskiy Prospect 4, Moscow 119049, Russia.
Krasnovskaya O; Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.; Department of Materials Science of Semiconductors and Dielectrics, National University of Science and Technology (MISIS), Leninskiy Prospect 4, Moscow 119049, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 15; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 15.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Chemical and Drug Induced Liver Injury*/drug therapy
Humans ; Tacrine/pharmacology ; Tacrine/therapeutic use ; Tacrine/chemistry ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Cholinesterase Inhibitors/chemistry ; Amyloid beta-Peptides/metabolism ; Acetylcholinesterase/metabolism
Czasopismo naukowe
Tytuł:
Polymer drug conjugates containing memantine, tacrine and cinnamic acid: promising nanotherapeutics for the treatment of Alzheimer's disease.
Autorzy:
Naki T; Department of Chemistry, University of Fort Hare, Alice, South Africa.
Matshe WMR; Polymer and Composites, CSIR Materials Science and Manufacturing, Pretoria, South Africa.
Balogun MO; Polymer and Composites, CSIR Materials Science and Manufacturing, Pretoria, South Africa.
Sinha Ray S; DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria, South Africa.
Egieyeh SA; School of Pharmacy, University of the Western Cape, Bellville Cape Town.
Aderibigbe BA; Department of Chemistry, University of Fort Hare, Alice, South Africa.
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Źródło:
Journal of microencapsulation [J Microencapsul] 2023 Jan; Vol. 40 (1), pp. 15-28. Date of Electronic Publication: 2023 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Nanoparticle Drug Delivery System*/chemistry
Nanoparticle Drug Delivery System*/pharmacology
Nanoparticle Drug Delivery System*/therapeutic use
Humans ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Cholinesterase Inhibitors/chemistry ; Memantine/chemistry ; Memantine/pharmacology ; Memantine/therapeutic use ; Tacrine/pharmacology ; Tacrine/chemistry ; Tacrine/therapeutic use ; Polymers/chemistry ; Polymers/pharmacology ; Polymers/therapeutic use
Czasopismo naukowe
Tytuł:
Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats.
Autorzy:
Zdarova Karasova J; Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.
Soukup O; Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.
Korabecny J; Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.
Hroch M; Faculty of Medicine, Department of Medicinal Biochemistry, Charles University in Prague, Hradec Kralove, Czech Republic.
Krejciova M; Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.
Hrabinova M; Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.
Misik J; Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.
Novotny L; Finn Pathologists, One Eyed Lane, Weybread, UK.
Hepnarova V; Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.
Kuca K; Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Department of Cellular Biology and Pharmacology, Florida International University, Miami, FL, USA.
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Źródło:
Drug and chemical toxicology [Drug Chem Toxicol] 2021 Mar; Vol. 44 (2), pp. 207-214. Date of Electronic Publication: 2019 Jul 01.
Typ publikacji:
Journal Article
MeSH Terms:
Brain/*metabolism
Cholinesterase Inhibitors/*administration & dosage
Tacrine/*analogs & derivatives
Animals ; Area Under Curve ; Cholinesterase Inhibitors/pharmacokinetics ; Cholinesterase Inhibitors/toxicity ; Male ; Rats ; Rats, Wistar ; Tacrine/administration & dosage ; Tacrine/pharmacokinetics ; Tacrine/toxicity ; Time Factors ; Tissue Distribution
Czasopismo naukowe
Tytuł:
Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments.
Autorzy:
Bautista-Aguilera ÓM; Departamento de Química Orgánica and Química Inorgánica. Ctra. Madrid-Barcelona, Universidad de Alcalá, Km. 33, 6, 28871, Madrid, Spain.
Ismaili L; Laboratoire de Chimie Organique et Thérapeutique, Neurosciences intégratives et cliniques EA 481, Univ. Bourgogne Franche-Comté, UFR Santé, 19, rue Ambroise Paré, F-25000, Besançon, France.
Iriepa I; Departamento de Química Orgánica and Química Inorgánica. Ctra. Madrid-Barcelona, Universidad de Alcalá, Km. 33, 6, 28871, Madrid, Spain.; Institute of Chemical Research Andrés M. del Río, Alcalá University, 28805-Alcalá de Henares, Madrid, Spain.
Diez-Iriepa D; Departamento de Química Orgánica and Química Inorgánica. Ctra. Madrid-Barcelona, Universidad de Alcalá, Km. 33, 6, 28871, Madrid, Spain.
Chabchoub F; Laboratoire de Chimie Appliquée: Hétérocycles, Corps Gras et Polymères, Faculté des Sciences de Sfax, Université de Sfax. B. P 802., 3000, Sfax, Tunisie.
Marco-Contelles J; Laboratory of Medicinal Chemistry (IQOG, CSIC), Juan de la Cierva 3, 28006-, Madrid, Spain.
Pérez M; Public Health Department, Faculty of Medicine and Nursing, University of the Basque Country., Leioa, Spain.
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Źródło:
Chemical record (New York, N.Y.) [Chem Rec] 2021 Jan; Vol. 21 (1), pp. 162-174. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease/*drug therapy
Cholinesterase Inhibitors/*pharmacology
Neuroprotective Agents/*pharmacology
Tacrine/*analogs & derivatives
Tacrine/*pharmacology
Acetylcholinesterase/metabolism ; Cell Line, Tumor ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/metabolism ; Humans ; Molecular Docking Simulation ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/metabolism ; Protein Binding ; Tacrine/metabolism
Czasopismo naukowe
Tytuł:
Tacrine-Coumarin Derivatives as Topoisomerase Inhibitors with Antitumor Effects on A549 Human Lung Carcinoma Cancer Cell Lines.
Autorzy:
Konkoľová E; Department of Biochemistry, Institute of Chemistry, Faculty of Science, P. J. Šafárik University in Kosice, 041 80 Košice, Slovakia.; Institute of Organic Chemistry and Biochemistry AS CR, Flemingovo námestí 2, 160 00 Prague 6, Czech Republic.
Hudáčová M; Department of Biochemistry, Institute of Chemistry, Faculty of Science, P. J. Šafárik University in Kosice, 041 80 Košice, Slovakia.
Hamuľaková S; Department of Organic Chemistry, Institute of Chemistry, Faculty of Science, P. J. Šafárik University in Košice, 041 80 Košice, Slovakia.
Jendželovský R; Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, 041 80 Košice, Slovakia.
Vargová J; Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, 041 80 Košice, Slovakia.
Ševc J; Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, 041 80 Košice, Slovakia.
Fedoročko P; Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, 041 80 Košice, Slovakia.
Kožurková M; Department of Biochemistry, Institute of Chemistry, Faculty of Science, P. J. Šafárik University in Kosice, 041 80 Košice, Slovakia.; Biomedical Research Center, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech Republic.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 20; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Coumarins/*pharmacology
DNA Topoisomerases, Type I/*metabolism
Poly-ADP-Ribose Binding Proteins/*antagonists & inhibitors
Tacrine/*pharmacology
Topoisomerase I Inhibitors/*pharmacology
Topoisomerase II Inhibitors/*pharmacology
A549 Cells ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Coumarins/chemistry ; DNA Topoisomerases, Type II/metabolism ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Poly-ADP-Ribose Binding Proteins/metabolism ; Tacrine/chemistry ; Topoisomerase I Inhibitors/chemistry ; Topoisomerase II Inhibitors/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's Disease.
Autorzy:
Fancellu G; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.; Department of Earth Sciences, University of Pisa, Pisa, Italy.
Chand K; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
Tomás D; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
Orlandini E; Department of Earth Sciences, University of Pisa, Pisa, Italy.
Piemontese L; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', Bari, Italy.
Silva DF; CNC-Center for Neuroscience and Cell Biology, Universidade de Coimbra, Coimbra, Portugal.
Cardoso SM; CNC-Center for Neuroscience and Cell Biology, Universidade de Coimbra, Coimbra, Portugal.; Institute of Molecular and Cell Biology, Faculty of Medicine, Universidade de Coimbra, Coimbra, Portugal.
Chaves S; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
Santos MA; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 211-226.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease/*drug therapy
Benzofurans/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Neuroprotective Agents/*pharmacology
Tacrine/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Animals ; Benzofurans/chemistry ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Electrophorus ; Humans ; Models, Molecular ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Structure-Activity Relationship ; Tacrine/chemistry
Czasopismo naukowe
Tytuł:
New Multifunctional Agents for Potential Alzheimer's Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones.
Autorzy:
Elkina NA; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Grishchenko MV; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Shchegolkov EV; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Makhaeva GF; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.
Kovaleva NV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.
Rudakova EV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.
Boltneva NP; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.
Lushchekina SV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.; Emanuel Institute of Biochemical Physics Russian Academy of Sciences, Moscow 119334, Russia.
Astakhova TY; Emanuel Institute of Biochemical Physics Russian Academy of Sciences, Moscow 119334, Russia.
Radchenko EV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.; Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia.
Palyulin VA; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.; Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia.
Zhilina EF; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Perminova AN; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Lapshin LS; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Burgart YV; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Saloutin VI; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Yekaterinburg 620990, Russia.
Richardson RJ; Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.; Center of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.; Michigan Institute for Computational Discovery and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
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Źródło:
Biomolecules [Biomolecules] 2022 Oct 24; Vol. 12 (11). Date of Electronic Publication: 2022 Oct 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Neuroprotective Agents*/therapeutic use
Humans ; Tacrine/pharmacology ; Tacrine/chemistry ; Butyrylcholinesterase/metabolism ; Acetylcholinesterase/metabolism ; Molecular Docking Simulation ; Cholinesterase Inhibitors/chemistry ; Amyloid beta-Peptides/metabolism
Czasopismo naukowe
Tytuł:
In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor.
Autorzy:
Gholami A; Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.; Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30, Göteborg, Sweden.
Minai-Tehrani D; Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran. d_.
Eriksson LA; Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30, Göteborg, Sweden. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jan 12; Vol. 13 (1), pp. 643. Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/drug therapy
Cholinesterase Inhibitors*/chemistry
Ondansetron*/pharmacology
Humans ; Acetylcholinesterase/metabolism ; Butyrylcholinesterase/metabolism ; Molecular Docking Simulation ; Rivastigmine/pharmacology ; Structure-Activity Relationship ; Tacrine/pharmacology
Czasopismo naukowe
Tytuł:
Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities.
Autorzy:
Chrienova Z; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Nepovimova E; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Andrys R; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Dolezal R; Biomedical Research Centre and Department of Neurology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Janockova J; Biomedical Research Centre and Department of Neurology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Muckova L; Biomedical Research Centre and Department of Neurology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
Fabova L; Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.
Soukup O; Biomedical Research Centre and Department of Neurology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Oleksak P; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Valis M; Biomedical Research Centre and Department of Neurology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.; Faculty of Medicine in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.
Korabecny J; Biomedical Research Centre and Department of Neurology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
Marco-Contelles J; Institute of General Organic Chemistry (CSIC), Laboratory of Medicinal Chemistry, Madrid, Spain.
Kuca K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 2605-2620.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Butyrylcholinesterase*/metabolism
Acetylcholinesterase/metabolism ; Amines ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Drug Design ; Humans ; Ligands ; Monoamine Oxidase ; Monoamine Oxidase Inhibitors/pharmacology ; Oxidoreductases ; Structure-Activity Relationship ; Tacrine/therapeutic use
Czasopismo naukowe

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