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Wyszukujesz frazę ""tacrolimus"" wg kryterium: Temat


Tytuł :
Molecular Pathways Leading to Induction of Cell Death and Anti-Proliferative Properties by Tacrolimus and mTOR Inhibitors in Liver Cancer Cells.
Autorzy :
Navarro-Villarán E; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.
de la Cruz-Ojeda P; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.
Contreras L; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Department of Genetics, University of Seville, Seville, Spain.
González R; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.
Negrete M; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.
Rodríguez-Hernández MA; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.
Marín-Gómez LM; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of General Surgery, Hospital University 'Virgen del Rocío'/CSIC/ University of Seville/IBiS, Seville, Spain.
Álamo-Martínez JM; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of General Surgery, Hospital University 'Virgen del Rocío'/CSIC/ University of Seville/IBiS, Seville, Spain.
Calvo A; Department of General Surgery, Hospital University of Puerto Real, Puerto Real, Spain.
Gómez-Bravo MA; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of General Surgery, Hospital University 'Virgen del Rocío'/CSIC/ University of Seville/IBiS, Seville, Spain.
de la Cruz J; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Department of Genetics, University of Seville, Seville, Spain.
Padillo J; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of General Surgery, Hospital University 'Virgen del Rocío'/CSIC/ University of Seville/IBiS, Seville, Spain.
Muntané J; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain, .; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of General Surgery, Hospital University 'Virgen del Rocío'/CSIC/ University of Seville/IBiS, Seville, Spain.
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2020 May 06; Vol. 54 (3), pp. 457-473.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*metabolism
Immunosuppressive Agents/*pharmacology
Liver Neoplasms/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Tacrolimus/*pharmacology
Tacrolimus Binding Proteins/*metabolism
Autophagy/drug effects ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Endoplasmic Reticulum Stress/drug effects ; Everolimus/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Hep G2 Cells ; Hepatocytes/drug effects ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Small Interfering ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/genetics ; Tacrolimus Binding Protein 1A/metabolism ; Tumor Suppressor Protein p53/metabolism ; eIF-2 Kinase/metabolism
Czasopismo naukowe
Tytuł :
Multiple genetic factors affecting the pharmacokinetic and pharmacodynamic processes of tacrolimus in Chinese myasthenia gravis patients.
Autorzy :
Meng HY; Department of Neurology, Xiangya Hospital of Central South University, Changsha, China.
Li X; Department of Clinical Pharmacology, Xiangya Hospital of Central South University, Changsha, China.; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, China.
Jin WL; Department of Neurology, Xiangya Hospital of Central South University, Changsha, China.
Yan CK; Department of Neurology, Xiangya Hospital of Central South University, Changsha, China.
Dong XH; Department of Neurology, Xiangya Hospital of Central South University, Changsha, China.
Xu Q; Department of Neurology, Xiangya Hospital of Central South University, Changsha, China.
Peng YY; Department of Neurology, Xiangya Hospital of Central South University, Changsha, China.
Li ZB; Department of Neurology, Xiangya Hospital of Central South University, Changsha, China.
Li Y; Department of Neurology, Xiangya Hospital of Central South University, Changsha, China.
Luo ZH; Department of Neurology, Xiangya Hospital of Central South University, Changsha, China.
Xu LQ; Department of Neurology, Xiangya Hospital of Central South University, Changsha, China.
Yang H; Department of Neurology, Xiangya Hospital of Central South University, Changsha, China. .
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Źródło :
European journal of clinical pharmacology [Eur J Clin Pharmacol] 2020 May; Vol. 76 (5), pp. 659-671. Date of Electronic Publication: 2020 Jan 18.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 CYP3A/*genetics
Myasthenia Gravis/*drug therapy
Myasthenia Gravis/*genetics
Tacrolimus/*pharmacokinetics
Tacrolimus/*pharmacology
Adolescent ; Adult ; Aged ; Asian Continental Ancestry Group ; Child ; Female ; Genotype ; Humans ; Immunosuppressive Agents/pharmacokinetics ; Immunosuppressive Agents/pharmacology ; Male ; MicroRNAs ; Middle Aged ; NFATC Transcription Factors/genetics ; Polymorphism, Single Nucleotide ; Tacrolimus Binding Proteins/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Combined Effect of Inter- and Intrapatient Variability in Tacrolimus Exposure on Graft Impairment Within a 3-Year Period Following Kidney Transplantation: A Single-Center Experience.
Autorzy :
Stefanović NZ; Department of Pharmacy, Faculty of Medicine, University of Nis, Dr Zorana Djindjica 81 Blvd., 18000, Nis, Serbia. .
Veličković-Radovanović RM; Department of Pharmacology With Toxicology, Faculty of Medicine, University of Nis, Dr Zorana Djindjica 81 Blvd., , 18000, Nis, Serbia.; Clinic of Nephrology, Clinical Center Nis, Dr Zorana Djindjica 48 Blvd., 18000, Nis, Serbia.
Danković KS; Faculty of Medicine, University of Nis, Dr Zorana Djindjica 81 Blvd., 18000, Nis, Serbia.
Mitić BP; Clinic of Nephrology, Clinical Center Nis, Dr Zorana Djindjica 48 Blvd., 18000, Nis, Serbia.; Department of Internal Medicine, Faculty of Medicine, University of Nis, Dr Zorana Djindjica 81 Blvd., 18000, Nis, Serbia.
Paunović GJ; Clinic of Nephrology, Clinical Center Nis, Dr Zorana Djindjica 48 Blvd., 18000, Nis, Serbia.
Cvetković MB; Clinic of Nephrology, Clinical Center Nis, Dr Zorana Djindjica 48 Blvd., 18000, Nis, Serbia.; Faculty of Medicine, University of Nis, Dr Zorana Djindjica 81 Blvd., 18000, Nis, Serbia.
Cvetković TP; Clinic of Nephrology, Clinical Center Nis, Dr Zorana Djindjica 48 Blvd., 18000, Nis, Serbia.; Department of Biochemistry, Faculty of Medicine, University of Nis, Dr Zorana Djindjica 81 Blvd., 18000, Nis, Serbia.
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Źródło :
European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2020 Dec; Vol. 45 (6), pp. 749-760.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 CYP3A/*genetics
Immunosuppressive Agents/*pharmacokinetics
Immunosuppressive Agents/*therapeutic use
Kidney Transplantation/*methods
Tacrolimus/*pharmacokinetics
Tacrolimus/*therapeutic use
ATP Binding Cassette Transporter, Subfamily B/genetics ; Adult ; Female ; Genotype ; Glomerular Filtration Rate ; Graft Survival ; Humans ; Immunosuppressive Agents/administration & dosage ; Isoenzymes/genetics ; Male ; Middle Aged ; Polymorphism, Genetic ; Retrospective Studies ; Tacrolimus/administration & dosage
Czasopismo naukowe
Tytuł :
Dosing algorithm for Tacrolimus in Tunisian Kidney transplant patients: Effect of CYP 3A4*1B and CYP3A4*22 polymorphisms.
Autorzy :
Ben-Fredj N; Laboratory of Pharmacology, Faculty of Medicine, University of Monastir, Tunisia.
Hannachi I; Laboratory of Pharmacology, Faculty of Medicine, University of Monastir, Tunisia; Faculty of Sciences of Bizerte, Carthage University, Tunisia. Electronic address: .
Chadli Z; Laboratory of Pharmacology, Faculty of Medicine, University of Monastir, Tunisia.
Ben-Romdhane H; Laboratory of Pharmacology, Faculty of Medicine, University of Monastir, Tunisia.
A Boughattas N; Laboratory of Pharmacology, Faculty of Medicine, University of Monastir, Tunisia.
Ben-Fadhel N; Laboratory of Pharmacology, Faculty of Medicine, University of Monastir, Tunisia.
Aouam K; Laboratory of Pharmacology, Faculty of Medicine, University of Monastir, Tunisia.
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Nov 15; Vol. 407, pp. 115245. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article
MeSH Terms :
Algorithms*
Kidney Transplantation*
Cytochrome P-450 CYP3A/*genetics
Immunosuppressive Agents/*administration & dosage
Tacrolimus/*administration & dosage
Adult ; Cross-Sectional Studies ; Female ; Genotype ; Humans ; Immunosuppressive Agents/therapeutic use ; Isoenzymes/genetics ; Linear Models ; Male ; Middle Aged ; Models, Theoretical ; Reproducibility of Results ; Tacrolimus/therapeutic use ; Tunisia ; Young Adult
Czasopismo naukowe
Tytuł :
Pregnancy in a liver transplant patient treated with everolimus and tacrolimus.
Autorzy :
Ciortea R; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj- Napoca; 2 nd Obstetrics and Gynecology Department, County Hospital, Cluj-Napoca, Romania. . .
Ciobanu L; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj- Napoca, Romania; Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania. . .
Matei E; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj- Napoca; Fundeni Clinical Institute, Bucharest, Romania. .
Zanfi C; Multiorgan Transplantation Department, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. .
Blaga LD; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj- Napoca; 2 nd Obstetrics and Gynecology Department, County Hospital, Cluj-Napoca, Romania. .
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Źródło :
Journal of gastrointestinal and liver diseases : JGLD [J Gastrointestin Liver Dis] 2020 Dec 13; Vol. 29 (4), pp. 685-686. Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Letter; Comment
MeSH Terms :
Liver Transplantation*
Tacrolimus*/adverse effects
Everolimus/adverse effects ; Graft Rejection ; Humans ; Immunosuppressive Agents/adverse effects ; Pregnancy ; Quality of Life
Opinia redakcyjna
Tytuł :
Exploratory Analysis of the Impact of an mHealth Medication Adherence Intervention on Tacrolimus Trough Concentration Variability: Post Hoc Results of a Randomized Controlled Trial.
Autorzy :
McGillicuddy JW; Medical University of South Carolina, Charleston, SC, USA.
Chandler JL; Medical University of South Carolina, Charleston, SC, USA.
Sox LR; Medical University of South Carolina, Charleston, SC, USA.
Taber DJ; Medical University of South Carolina, Charleston, SC, USA.
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Źródło :
The Annals of pharmacotherapy [Ann Pharmacother] 2020 Dec; Vol. 54 (12), pp. 1185-1193. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
MeSH Terms :
Kidney Transplantation*
Drug Monitoring/*methods
Graft Rejection/*prevention & control
Immunosuppressive Agents/*administration & dosage
Medication Adherence/*statistics & numerical data
Tacrolimus/*administration & dosage
Adult ; Drug Monitoring/statistics & numerical data ; Electronic Health Records ; Female ; Graft Rejection/epidemiology ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Middle Aged ; Prospective Studies ; Reminder Systems/statistics & numerical data ; Risk Factors ; Tacrolimus/therapeutic use ; Telemedicine
Czasopismo naukowe
Tytuł :
FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals.
Autorzy :
Kang HJ; Department of Life Science, Chung-Ang University, Seoul, South Korea.
Yoon S; Ewha Brain Institute, Ewha W. University, Seoul, South Korea.; Department of Brain and Cognitive Sciences, Ewha W. University, Seoul, South Korea.
Lee S; Ewha Brain Institute, Ewha W. University, Seoul, South Korea.; Department of Brain and Cognitive Sciences, Ewha W. University, Seoul, South Korea.
Choi K; Department of Life Science, Chung-Ang University, Seoul, South Korea.
Seol S; Department of Life Science, Chung-Ang University, Seoul, South Korea.
Park S; Ewha Brain Institute, Ewha W. University, Seoul, South Korea.
Namgung E; Ewha Brain Institute, Ewha W. University, Seoul, South Korea.
Kim TD; Ewha Brain Institute, Ewha W. University, Seoul, South Korea.
Chung YA; Department of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Kim J; Ewha Brain Institute, Ewha W. University, Seoul, South Korea.; Department of Brain and Cognitive Sciences, Ewha W. University, Seoul, South Korea.
Han JS; Department of Biological Sciences, Konkuk University, Seoul, South Korea.
Lyoo IK; Ewha Brain Institute, Ewha W. University, Seoul, South Korea. .; Department of Brain and Cognitive Sciences, Ewha W. University, Seoul, South Korea. .; Graduate School of Pharmaceutical Sciences, Ewha W. University, Seoul, South Korea. .; The Brain Institute and Department of Psychiatry, University of Utah, Salt Lake City, Utah, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Feb 25; Vol. 10 (1), pp. 3353. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
MicroRNAs/*genetics
Stress Disorders, Post-Traumatic/*genetics
Tacrolimus Binding Proteins/*genetics
Adult ; Animals ; Biomarkers/metabolism ; Disease Models, Animal ; Epigenesis, Genetic/genetics ; Female ; Gene Expression Regulation/drug effects ; Genotype ; Humans ; Male ; Mice ; Mice, Knockout ; Polymorphism, Single Nucleotide/genetics ; Prefrontal Cortex/diagnostic imaging ; Prefrontal Cortex/physiopathology ; Stress Disorders, Post-Traumatic/physiopathology ; Tacrolimus/pharmacology
Czasopismo naukowe
Tytuł :
Model-based assessment of pharmacokinetic changes of sunitinib, tacrolimus, and everolimus in a patient with metastatic renal cell carcinoma after renal transplantation.
Autorzy :
Ito T; Department of Pharmacy, Kobe University Hospital, Japan. Electronic address: .
Yamamoto K; Department of Pharmacy, Kobe University Hospital, Japan. Electronic address: .
Ogawa S; Division of Urology, Graduate School of Medicine, Kobe University, Japan. Electronic address: .
Furukawa J; Division of Urology, Graduate School of Medicine, Kobe University, Japan. Electronic address: .
Harada K; Division of Urology, Graduate School of Medicine, Kobe University, Japan. Electronic address: .
Fujisawa M; Division of Urology, Graduate School of Medicine, Kobe University, Japan. Electronic address: .
Omura T; Department of Pharmacy, Kobe University Hospital, Japan. Electronic address: .
Yano I; Department of Pharmacy, Kobe University Hospital, Japan. Electronic address: .
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Źródło :
Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2020 Oct; Vol. 35 (5), pp. 405-409. Date of Electronic Publication: 2020 Jun 06.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Kidney Transplantation*
Antineoplastic Combined Chemotherapy Protocols/*pharmacokinetics
Carcinoma, Renal Cell/*therapy
Everolimus/*pharmacokinetics
Kidney Neoplasms/*therapy
Sunitinib/*pharmacokinetics
Tacrolimus/*pharmacokinetics
Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/secondary ; Combined Modality Therapy ; Everolimus/administration & dosage ; Everolimus/therapeutic use ; Humans ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/secondary ; Male ; Sunitinib/administration & dosage ; Sunitinib/therapeutic use ; Tacrolimus/administration & dosage ; Tacrolimus/therapeutic use
Czasopismo naukowe
Tytuł :
Conversion From a Twice-Daily to a Once-Daily Tacrolimus Formulation in Kidney Transplant Recipients.
Autorzy :
Kamińska D; Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland. Electronic address: .
Poznański P; Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.
Kuriata-Kordek M; Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.
Zielińska D; Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.
Mazanowska O; Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.
Kościelska-Kasprzak K; Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.
Krajewska M; Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.
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Źródło :
Transplantation proceedings [Transplant Proc] 2020 Oct; Vol. 52 (8), pp. 2288-2293. Date of Electronic Publication: 2020 Apr 02.
Typ publikacji :
Journal Article
MeSH Terms :
Kidney Transplantation*
Immunosuppressive Agents/*administration & dosage
Immunosuppressive Agents/*blood
Tacrolimus/*administration & dosage
Tacrolimus/*blood
Adolescent ; Adult ; Aged ; Biological Availability ; Delayed-Action Preparations ; Drug Administration Schedule ; Female ; Humans ; Immunosuppressive Agents/pharmacokinetics ; Male ; Middle Aged ; Tacrolimus/pharmacokinetics ; Young Adult
Czasopismo naukowe
Tytuł :
COVID-19 in a young liver transplant recipient: caution for drug-drug interactions.
Autorzy :
Dajti E; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. . .
Cristini F; Infectious Diseases Unit, Rimini-Forlì-Cesena Hospitals, Rimini, Italy. .
Tamanini G; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. .
Cescon M; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. .
Bazzoli F; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. .
Tamè M; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. .
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Źródło :
Journal of gastrointestinal and liver diseases : JGLD [J Gastrointestin Liver Dis] 2020 Sep 09; Vol. 29 (3), pp. 470. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Acute Kidney Injury*/chemically induced
Acute Kidney Injury*/diagnosis
Acute Kidney Injury*/prevention & control
Coronavirus Infections*/diagnosis
Coronavirus Infections*/drug therapy
Coronavirus Infections*/physiopathology
Darunavir*/administration & dosage
Darunavir*/adverse effects
Drug Interactions*
Hydroxychloroquine*/administration & dosage
Hydroxychloroquine*/adverse effects
Pandemics*
Pneumonia, Viral*/diagnosis
Pneumonia, Viral*/drug therapy
Pneumonia, Viral*/physiopathology
Prednisone*/administration & dosage
Prednisone*/adverse effects
Ritonavir*/administration & dosage
Ritonavir*/adverse effects
Tacrolimus*/administration & dosage
Tacrolimus*/adverse effects
Tacrolimus*/blood
Liver Transplantation/*methods
Adult ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Drug Monitoring/methods ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/blood ; Male ; Risk Adjustment/methods ; SARS-CoV-2 ; Transplant Recipients ; Treatment Outcome
Raport
Tytuł :
Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52.
Autorzy :
de la Sierra-Gallay IL; Institut de Biologie Intégrative de la Cellule (I2BC), CNRS UMR9198, Université Paris-Saclay, Université Paris-Sud, 91405 Orsay, France.
Belnou M; Sorbonne Université, École normale supérieure, PSL University, CNRS, Laboratoire des biomolécules, LBM, 75005 Paris, France.
Chambraud B; INSERM UMR 1195, Université Paris XI, 94270 Le Kremlin Bicêtre, France.
Genet M; Institut Baulieu, INSERM UMR 1195, Neuroprotection et Neurorégénération, Université Paris-Saclay, 94270Le Kremlin Bicêtre, France.
van Tilbeurgh H; Institut de Biologie Intégrative de la Cellule (I2BC), CNRS UMR9198, Université Paris-Saclay, Université Paris-Sud, 91405 Orsay, France.
Aumont-Nicaise M; Institut de Biologie Intégrative de la Cellule (I2BC), CNRS UMR9198, Université Paris-Saclay, Université Paris-Sud, 91405 Orsay, France.
Desmadril M; Institut de Biologie Intégrative de la Cellule (I2BC), CNRS UMR9198, Université Paris-Saclay, Université Paris-Sud, 91405 Orsay, France.
Baulieu EE; Institut Baulieu, INSERM UMR 1195, Neuroprotection et Neurorégénération, Université Paris-Saclay, 94270Le Kremlin Bicêtre, France.
Jacquot Y; Cibles Thérapeutiques et Conception de Médicaments (CiTCoM), CNRS UMR 8038, INSERM U1268, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 75270 Paris Cedex 06, France.
Byrne C; Sorbonne Université, École normale supérieure, PSL University, CNRS, Laboratoire des biomolécules, LBM, 75005 Paris, France.; Institut Baulieu, INSERM UMR 1195, Neuroprotection et Neurorégénération, Université Paris-Saclay, 94270Le Kremlin Bicêtre, France.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Sep 24; Vol. 63 (18), pp. 10330-10338. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorescent Dyes/*metabolism
Oligopeptides/*metabolism
Tacrolimus Binding Proteins/*metabolism
Fluorescence Resonance Energy Transfer ; Fluorescent Dyes/chemical synthesis ; Humans ; Ligands ; Oligopeptides/chemical synthesis ; Protein Binding ; Protein Domains ; Tacrolimus Binding Proteins/chemistry
Czasopismo naukowe
Tytuł :
Tacrolimus ointment in the treatment of hormone-dependent dermatitis: A protocol of systematic review.
Autorzy :
Li M; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu.
Tan W; Guanghan People's Hospital of Sichuan Province, Deyang, China.
Du J; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu.
Wang Q; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu.
Wang L; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu.
Lei M; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu.
Hao PS; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu.
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Sep 11; Vol. 99 (37), pp. e22159.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Adrenal Cortex Hormones/*adverse effects
Calcineurin Inhibitors/*therapeutic use
Drug Eruptions/*drug therapy
Drug Eruptions/*etiology
Tacrolimus/*therapeutic use
Administration, Cutaneous ; Adrenal Cortex Hormones/administration & dosage ; Calcineurin Inhibitors/administration & dosage ; Humans ; Ointments ; Randomized Controlled Trials as Topic ; Research Design ; Tacrolimus/administration & dosage
Czasopismo naukowe
Tytuł :
Tacrolimus and Mycophenolic Acid Blood Concentration and Cellular Rejection After Heart Transplantation in First Endomyocardial Biopsy.
Autorzy :
Nadziakiewicz P; Department of Cardiac Anesthesia and Intensive Therapy, Silesian Centre for Heart Diseases, Medical University of Silesia, Zabrze, Poland. Electronic address: .
Grochla M; Department of Cardiac Anesthesia and Intensive Therapy, Silesian Centre for Heart Diseases, Medical University of Silesia, Zabrze, Poland.
Krauchuk A; Department of Anaesthesiology, Medical University of Silesia, Szpital Specjalistyczny, Zabrze, Poland.
Szyguła-Jurkiewicz B; 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
Lorek J; Students' Scientific Society, Department of Cardiac Anesthesia and Intensive Therapy, Silesian Centre for Heart Diseases, Medical University of Silesia, Zabrze, Poland.
Barańska A; Students' Scientific Society, Department of Cardiac Anesthesia and Intensive Therapy, Silesian Centre for Heart Diseases, Medical University of Silesia, Zabrze, Poland.
Zembala MO; Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, School of Medicine with the Division of Dentistry in Zabrze, Silesian Centre for Heart Diseases, Zabrze, Poland.
Przybyłowski P; Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Silesian Centre for Heart Diseases, Medical University of Silesia, Zabrze, Poland; General Surgery, Medical College, Jagiellonian University, Cracow, Poland.
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Źródło :
Transplantation proceedings [Transplant Proc] 2020 Sep; Vol. 52 (7), pp. 2094-2097. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji :
Journal Article
MeSH Terms :
Graft Rejection/*epidemiology
Heart Transplantation/*adverse effects
Immunosuppressive Agents/*blood
Mycophenolic Acid/*blood
Tacrolimus/*blood
Adult ; Female ; Graft Rejection/prevention & control ; Humans ; Immunosuppressive Agents/pharmacokinetics ; Incidence ; Male ; Middle Aged ; Mycophenolic Acid/pharmacokinetics ; Retrospective Studies ; Tacrolimus/pharmacokinetics
Czasopismo naukowe
Tytuł :
DAnkrd49 and Bdbt act via Casein kinase Iε to regulate planar polarity in Drosophila.
Autorzy :
Strutt H; Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, United Kingdom.
Strutt D; Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, United Kingdom.
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Źródło :
PLoS genetics [PLoS Genet] 2020 Aug 04; Vol. 16 (8), pp. e1008820. Date of Electronic Publication: 2020 Aug 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Polarity*
Morphogenesis*
Casein Kinase Iepsilon/*metabolism
Drosophila Proteins/*metabolism
Tacrolimus Binding Proteins/*metabolism
Animals ; Casein Kinase Iepsilon/genetics ; Dishevelled Proteins/genetics ; Dishevelled Proteins/metabolism ; Drosophila Proteins/genetics ; Drosophila melanogaster ; Loss of Function Mutation ; Protein Binding ; Protein Transport ; Tacrolimus Binding Proteins/genetics ; Wings, Animal/cytology ; Wings, Animal/growth & development
Czasopismo naukowe
Tytuł :
USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling.
Autorzy :
Zhao X; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Wu X; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Wang H; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Yu H; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Wang J; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2020 Aug; Vol. 59 (8), pp. 1000-1011. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Glycolysis*
Adenocarcinoma of Lung/*pathology
Proto-Oncogene Proteins c-akt/*metabolism
Tacrolimus Binding Proteins/*metabolism
Ubiquitin-Specific Proteases/*metabolism
Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/metabolism ; Animals ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Case-Control Studies ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Mice ; Mice, Nude ; Middle Aged ; Prognosis ; Proto-Oncogene Proteins c-akt/genetics ; Tacrolimus Binding Proteins/genetics ; Tumor Cells, Cultured ; Ubiquitin-Specific Proteases/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.
Autorzy :
Juvvadi PR; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address: .
Bobay BG; Duke University NMR Center, Duke University Medical Center, Durham, NC, 27710, USA; Department of Biochemistry, Durham, NC, 27710, USA; Department of Radiology, Duke University, Durham, NC, 27710, USA.
Gobeil SMC; Department of Biochemistry, Durham, NC, 27710, USA; Department of Radiology, Duke University, Durham, NC, 27710, USA.
Cole DC; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA.
Venters RA; Duke University NMR Center, Duke University Medical Center, Durham, NC, 27710, USA; Department of Biochemistry, Durham, NC, 27710, USA; Department of Radiology, Duke University, Durham, NC, 27710, USA.
Heitman J; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA.
Spicer LD; Duke University NMR Center, Duke University Medical Center, Durham, NC, 27710, USA; Department of Biochemistry, Durham, NC, 27710, USA; Department of Radiology, Duke University, Durham, NC, 27710, USA.
Steinbach WJ; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 May 21; Vol. 526 (1), pp. 48-54. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Multimerization*
Aspergillus fumigatus/*metabolism
Calcineurin/*metabolism
Calcineurin Inhibitors/*pharmacology
Fungal Proteins/*genetics
Mutation/*genetics
Tacrolimus/*pharmacology
Tacrolimus Binding Protein 1A/*genetics
Amino Acid Sequence ; Computer Simulation ; Fungal Proteins/chemistry ; Fungal Proteins/metabolism ; Humans ; Mutant Proteins/chemistry ; Mutant Proteins/metabolism ; Protein Binding/drug effects ; Protein Structure, Secondary ; Tacrolimus Binding Protein 1A/chemistry ; Tacrolimus Binding Protein 1A/metabolism
Czasopismo naukowe
Tytuł :
Expanding the Chemogenetic Toolbox by Circular Permutation.
Autorzy :
Lee YT; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA.
He L; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA. Electronic address: .
Zhou Y; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA; Department of Medical Physiology, College of Medicine, Texas A&M University, Bryan, TX 77807, USA; Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, TX 77030, USA. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2020 May 01; Vol. 432 (10), pp. 3127-3136. Date of Electronic Publication: 2020 Apr 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Engineering/*methods
Recombinant Proteins/*metabolism
Tacrolimus Binding Protein 1A/*chemistry
Tacrolimus Binding Proteins/*genetics
Cloning, Molecular ; HEK293 Cells ; HeLa Cells ; Humans ; Ligands ; Protein Domains ; Protein Structure, Secondary ; Recombinant Proteins/chemistry ; Sirolimus/pharmacology ; Synthetic Biology ; Tacrolimus Binding Protein 1A/genetics ; Tacrolimus Binding Protein 1A/metabolism ; Tacrolimus Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Tacrolimus trough levels higher than 6 ng/mL might not be required after a year in stable kidney transplant recipients.
Autorzy :
Jung HY; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Seo MY; Department of Internal Medicine, Pohang St. Mary's Hospital, Pohang, South Korea.
Jeon Y; Department of Statistics, Kyungpook National University, Daegu, South Korea.
Huh KH; Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea.
Park JB; Department of Surgery, Sungkyunkwan University, Seoul Samsung Medical Center, Seoul, South Korea.
Jung CW; Department of Surgery, Korea University College of Medicine, Seoul, South Korea.
Lee S; Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, South Korea.
Han SY; Department of Internal Medicine, Keimyung University, Dongsan Medical Center, Daegu, South Korea.
Ro H; Department of Internal Medicine, Gachon University, Gil Hospital, Incheon, South Korea.
Yang J; Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea.
Ahn C; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Choi JY; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Cho JH; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Park SH; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Kim YL; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Kim CD; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
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Źródło :
PloS one [PLoS One] 2020 Jul 02; Vol. 15 (7), pp. e0235418. Date of Electronic Publication: 2020 Jul 02 (Print Publication: 2020).
Typ publikacji :
Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunosuppressive Agents*/administration & dosage
Immunosuppressive Agents*/adverse effects
Immunosuppressive Agents*/blood
Tacrolimus*/administration & dosage
Tacrolimus*/adverse effects
Tacrolimus*/blood
Immunosuppression/*adverse effects
Kidney Transplantation/*rehabilitation
Adult ; Cardiovascular Diseases/chemically induced ; Cohort Studies ; Cytomegalovirus Infections/chemically induced ; Female ; Graft Rejection/chemically induced ; Humans ; Male ; Middle Aged ; Opportunistic Infections/chemically induced ; Polyomavirus Infections/chemically induced ; Renal Insufficiency/chemically induced ; Republic of Korea
Czasopismo naukowe
Tytuł :
Impact of Donor and Recipient CYP3A5*3 Genotype on Tacrolimus Population Pharmacokinetics in Chinese Adult Liver Transplant Recipients.
Autorzy :
Shao J; Tianjin First Central Hospital, Tianjin, China.
Wang C; Huashan Hospital, Fudan University, Shanghai, China.
Fu P; Tianjin First Central Hospital, Tianjin, China.
Chen F; Tianjin First Central Hospital, Tianjin, China.
Zhang Y; Tianjin First Central Hospital, Tianjin, China.
Wei J; Tianjin University of Traditional Chinese Medicine, Tianjin, China.
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Źródło :
The Annals of pharmacotherapy [Ann Pharmacother] 2020 Jul; Vol. 54 (7), pp. 652-661. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver Transplantation*
Models, Biological*
Polymorphism, Genetic*
Cytochrome P-450 CYP3A/*genetics
Immunosuppressive Agents/*pharmacokinetics
Tacrolimus/*pharmacokinetics
Adult ; Asian Continental Ancestry Group ; Drug Monitoring ; Female ; Genotype ; Humans ; Immunosuppressive Agents/administration & dosage ; Male ; Metabolic Clearance Rate ; Middle Aged ; Tacrolimus/administration & dosage ; Tissue Donors ; Transplant Recipients
Czasopismo naukowe
Tytuł :
Absence of interaction between rivaroxaban, tacrolimus and everolimus in renal transplant recipients with deep vein thrombosis or atrial fibrillation.
Autorzy :
Camporese G; Angiology Unit, Department of Cardiac, Thoracic and Vascular Sciences, Padova University Hospital, Italy. Electronic address: .
Bernardi D; Department of Laboratory Medicine, Padova University Hospital, Italy.
Bernardi E; Department of Emergency and Accident Medicine, Conegliano Hospital, Italy.
Avruscio GP; Angiology Unit, Department of Cardiac, Thoracic and Vascular Sciences, Padova University Hospital, Italy.
Marchini F; Division of Nephrology and Renal Transplantation, Padova University Hospital, Italy.
Bonfante L; Division of Nephrology and Renal Transplantation, Padova University Hospital, Italy.
Furian L; Department of Surgery, Oncology and Gastroenterology, Padova University Hospital, Italy.
Neri F; Department of Surgery, Oncology and Gastroenterology, Padova University Hospital, Italy.
Villalta S; Department of Internal Medicine, Internal Medicine AULSS2 Marca Trevigiana, Treviso Hospital, Italy.
Fabris F; Department of Internal Medicine, Clinical Medicine 1, Padova University Hospital, Italy.
Simioni P; Department of Internal Medicine, General Medicine Unit, Thrombotic and Haemorrhagic Disorders Unit, Padova University Hospital, Italy.
Sartori MT; Department of Internal Medicine, Clinical Medicine 1, Padova University Hospital, Italy.
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Źródło :
Vascular pharmacology [Vascul Pharmacol] 2020 Jul; Vol. 130, pp. 106682. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Kidney Transplantation*/adverse effects
Atrial Fibrillation/*drug therapy
Everolimus/*pharmacokinetics
Factor Xa Inhibitors/*pharmacokinetics
Immunosuppressive Agents/*pharmacokinetics
Rivaroxaban/*pharmacokinetics
Tacrolimus/*pharmacokinetics
Venous Thrombosis/*drug therapy
Aged ; Atrial Fibrillation/blood ; Atrial Fibrillation/diagnosis ; Blood Coagulation/drug effects ; Drug Interactions ; Drug Monitoring ; Everolimus/adverse effects ; Everolimus/blood ; Factor Xa Inhibitors/adverse effects ; Factor Xa Inhibitors/blood ; Female ; Graft Survival/drug effects ; Hemorrhage/chemically induced ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/blood ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Rivaroxaban/adverse effects ; Rivaroxaban/blood ; Tacrolimus/adverse effects ; Tacrolimus/blood ; Treatment Outcome ; Venous Thrombosis/blood ; Venous Thrombosis/diagnosis
Czasopismo naukowe

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