Temat: "target of rapamycin complex 1" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Unraveling the Role of Ras Homolog Enriched in Brain (Rheb1 and Rheb2): Bridging Neuronal Dynamics and Cancer Pathogenesis through Mechanistic Target of Rapamycin Signaling.
Autorzy:: Rahman M; College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.
Nguyen TM; College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.
Lee GJ; College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.
Kim B; College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.
Park MK; Department of BioHealthcare, Hwasung Medi-Science University, Hwaseong-si 18274, Republic of Korea.
Lee CH; College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 25; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 25.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Neoplasms*/metabolism
Ras Homolog Enriched in Brain Protein*/genetics
Ras Homolog Enriched in Brain Protein*/metabolism
Mechanistic Target of Rapamycin Complex 1*/metabolism
Brain/metabolism ; Neurons/metabolism ; Neuropeptides/metabolism ; Sirolimus

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Skocz do pozycji: 2.

Tytuł:: mTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction.
Autorzy:: de Souza GO; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
Teixeira PDS; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
Câmara NOS; Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
Donato J Jr; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, SP, Brazil.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Oct 12; Vol. 12 (20). Date of Electronic Publication: 2023 Oct 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Eating*/physiology
Mechanistic Target of Rapamycin Complex 1*/metabolism
Neurons*/metabolism
Animals ; Female ; Male ; Mice ; Agouti-Related Protein/metabolism ; Glucose/metabolism

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Skocz do pozycji: 3.

Tytuł:: GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1.
Autorzy:: Muller M; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Bélanger J; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Hadj-Aissa I; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Zhang C; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Sephton CF; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Dutchak PA; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 08; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:: Journal Article
MeSH Terms:: Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Epilepsy*
Humans ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Signal Transduction ; GTPase-Activating Proteins/metabolism ; Mutation ; Phosphatidylinositol 3-Kinase/metabolism ; Amino Acids/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Membrane Transport Proteins/metabolism ; Nitrogen/metabolism

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Skocz do pozycji: 4.

Tytuł:: The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle.
Autorzy:: Ryan PJ; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Uranga S; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Stanelle ST; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Lewis MH; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
O'Reilly CL; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Cardin JM; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Deaver JW; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Morton AB; Soft Tissue Regeneration and Applied Biomaterials Laboratory, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Fluckey JD; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Apr 06; Vol. 14 (1), pp. 8094. Date of Electronic Publication: 2024 Apr 06.
Typ publikacji:: Journal Article
MeSH Terms:: TOR Serine-Threonine Kinases*
Autophagy*/physiology
Aminopyridines*
Mechanistic Target of Rapamycin Complex 1/metabolism ; Muscle, Skeletal/metabolism

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Skocz do pozycji: 5.

Tytuł:: Pharmacological inhibition of mTORC1 reduces neural death and damage volume after MCAO by modulating microglial reactivity.
Autorzy:: Villa-González M; Departamento de Biología (Fisiología Animal), Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.
Rubio M; Physiopathology and Imaging of Neurological Disorders, Normandie University, UNICAEN, UMR-S U1237, INSERM, Institut Blood and Brain @ CaenNormandie, GIP Cyceron, Caen, France.
Martín-López G; Departamento de Biología (Fisiología Animal), Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.
Mallavibarrena PR; Departamento de Biología (Fisiología Animal), Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.
Vallés-Saiz L; Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
Vivien D; Physiopathology and Imaging of Neurological Disorders, Normandie University, UNICAEN, UMR-S U1237, INSERM, Institut Blood and Brain @ CaenNormandie, GIP Cyceron, Caen, France.; Department of Clinical Research, Caen-Normandie Hospital (CHU), Caen, France.
Wandosell F; Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain. .; Centro de Investigaciones Biológicas en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. .
Pérez-Álvarez MJ; Departamento de Biología (Fisiología Animal), Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain. .; Instituto Universitario de Biología Molecular (IUBM-UAM), Madrid, Spain. .; Pokaż więcej
Źródło:: Biology direct [Biol Direct] 2024 Apr 06; Vol. 19 (1), pp. 26. Date of Electronic Publication: 2024 Apr 06.
Typ publikacji:: Journal Article
MeSH Terms:: Microglia*
Brain Ischemia*/drug therapy
Brain Ischemia*/genetics
Mice ; Animals ; Mechanistic Target of Rapamycin Complex 1 ; Neuroinflammatory Diseases ; TOR Serine-Threonine Kinases/therapeutic use ; Ischemia ; Sirolimus/pharmacology ; Sirolimus/therapeutic use ; Mammals

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Skocz do pozycji: 6.

Tytuł:: Polyploidy and mTOR signaling: a possible molecular link.
Autorzy:: Choudhury D; Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, India.
Ghosh D; Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, India.
Mondal M; Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, India.
Singha D; Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, India.
Pothuraju R; Cancer Research Program, Rajiv Gandhi Center for Biotechnology (RGCB), Thiruvananthapuram, 695014, Kerala, India.
Malakar P; Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, India. .; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Mar 27; Vol. 22 (1), pp. 196. Date of Electronic Publication: 2024 Mar 27.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Neoplasms*/genetics
Neoplasms*/metabolism
Diabetes Mellitus*
Animals ; Humans ; TOR Serine-Threonine Kinases/metabolism ; Signal Transduction ; Polyploidy ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Mammals/metabolism

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Skocz do pozycji: 7.

Tytuł:: mTORC1 is required for differentiation of germline stem cells in the Drosophila melanogaster testis.
Autorzy:: Clémot M; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States of America.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, United States of America.
D'Alterio C; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States of America.
Kwang AC; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States of America.
Jones DL; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States of America.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, United States of America.; Departments of Anatomy, Division of Geriatrics, University of California, San Francisco, San Francisco, CA, United States of America.; Departments of Medicine, Division of Geriatrics, University of California, San Francisco, San Francisco, CA, United States of America.; Eli and Edythe Broad Center for Regeneration Medicine, University of California, San Francisco, San Francisco, CA, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2024 Mar 21; Vol. 19 (3), pp. e0300337. Date of Electronic Publication: 2024 Mar 21 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Drosophila melanogaster*/metabolism
Drosophila Proteins*/metabolism
Animals ; Male ; Testis/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Cell Differentiation ; Drosophila/metabolism ; Stem Cells ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Germ Cells/metabolism

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Skocz do pozycji: 8.

Tytuł:: Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets.
Autorzy:: Jhanwar-Uniyal M; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Zeller SL; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Spirollari E; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Das M; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Hanft SJ; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Gandhi CD; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.; Pokaż więcej
Źródło:: Cells [Cells] 2024 Feb 27; Vol. 13 (5). Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Glioblastoma*/metabolism
Sirolimus*/pharmacology
Neoplastic Stem Cells*/metabolism
Humans ; Intercellular Signaling Peptides and Proteins/therapeutic use ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism

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Skocz do pozycji: 9.

Tytuł:: TFEB activation triggers pexophagy for functional adaptation during oxidative stress under calcium deficient-conditions.
Autorzy:: Manandhar L; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Dutta RK; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.; Present address: Department of Chemistry (Biochemistry Division) Crosley Tower, University of Cincinnati, Cincinnati, Ohio, 45221, USA.
Devkota P; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Chhetri A; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Wei X; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Park C; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Kwon HM; School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
Park R; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea. .; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Feb 21; Vol. 22 (1), pp. 142. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Macroautophagy*
Calcium*/metabolism
Reactive Oxygen Species/metabolism ; Catalase/metabolism ; Oxidative Stress ; Autophagy/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism

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Skocz do pozycji: 10.

Tytuł:: Carnosic Acid against Lung Cancer: Induction of Autophagy and Activation of Sestrin-2/LKB1/AMPK Signalling.
Autorzy:: O'Neill EJ; Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
Sze NSK; Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
MacPherson REK; Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
Tsiani E; Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 06; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:: Journal Article
MeSH Terms:: Abietanes*/pharmacology
Abietanes*/therapeutic use
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/drug therapy
Lung Neoplasms*/pathology
Humans ; AMP-Activated Protein Kinases/drug effects ; AMP-Activated Protein Kinases/metabolism ; Apoptosis ; Autophagy/drug effects ; Cell Line, Tumor ; Mechanistic Target of Rapamycin Complex 1 ; Protein Serine-Threonine Kinases/metabolism ; Sestrins/drug effects ; Sestrins/metabolism ; AMP-Activated Protein Kinase Kinases/drug effects ; AMP-Activated Protein Kinase Kinases/metabolism

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Skocz do pozycji: 11.

Tytuł:: Tissue-specific expression differences in Ras-related GTP-binding proteins in male rats.
Autorzy:: Kincheloe GN; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Roberson PA; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Jefferson LS; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Kimball SR; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, USA.; Pokaż więcej
Źródło:: Physiological reports [Physiol Rep] 2024 Feb; Vol. 12 (3), pp. e15928.
Typ publikacji:: Journal Article
MeSH Terms:: Signal Transduction*/physiology
Monomeric GTP-Binding Proteins*/genetics
Monomeric GTP-Binding Proteins*/chemistry
Monomeric GTP-Binding Proteins*/metabolism
Male ; Rats ; Animals ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Amino Acids/metabolism ; RNA, Messenger/genetics

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Skocz do pozycji: 12.

Tytuł:: Phosphoregulation of the yeast Pma1 H+-ATPase autoinhibitory domain involves the Ptk1/2 kinases and the Glc7 PP1 phosphatase and is under TORC1 control.
Autorzy:: Guarini N; Molecular Physiology of the Cell, Université Libre de Bruxelles (ULB), Biopark, Gosselies, Belgium.
Saliba E; Molecular Physiology of the Cell, Université Libre de Bruxelles (ULB), Biopark, Gosselies, Belgium.
André B; Molecular Physiology of the Cell, Université Libre de Bruxelles (ULB), Biopark, Gosselies, Belgium.; Pokaż więcej
Źródło:: PLoS genetics [PLoS Genet] 2024 Jan 16; Vol. 20 (1), pp. e1011121. Date of Electronic Publication: 2024 Jan 16 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Saccharomyces cerevisiae*/metabolism
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Phosphoric Monoester Hydrolases/metabolism ; Proton-Translocating ATPases/genetics ; Proton-Translocating ATPases/metabolism ; Cell Membrane/genetics ; Cell Membrane/metabolism

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Skocz do pozycji: 13.

Tytuł:: RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling.
Autorzy:: Hu S; Department of Pulmonary and Critical Care Medicine, The General Hospital of Western Theater Command, Chengdu, China.
Zhang Y; Department of Geriatrics, The General Hospital of Western Theater Command, Chengdu, China.
Qiu C; Department of Burn, The General Hospital of Western Theater Command, Chengdu, China.
Li Y; Department of Geriatrics, The General Hospital of Western Theater Command, Chengdu, China.; Pokaż więcej
Źródło:: Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2023 Dec 31; Vol. 45 (1), pp. 2271186. Date of Electronic Publication: 2023 Oct 25.
Typ publikacji:: Journal Article
MeSH Terms:: Hypertension, Pulmonary*/metabolism
RGS Proteins*/genetics
RGS Proteins*/metabolism
RGS Proteins*/pharmacology
Animals ; Mice ; Cell Proliferation ; Cells, Cultured ; GTP-Binding Proteins/metabolism ; GTP-Binding Proteins/pharmacology ; Hypertrophy, Right Ventricular ; Hypoxia/metabolism ; Mammals/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 1/pharmacology ; Myocytes, Smooth Muscle/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Pulmonary Artery

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Skocz do pozycji: 14.

Tytuł:: Glucose promotes cell growth and casein synthesis via ATF4/Nrf2-Sestrin2- AMPK-mTORC1 pathway in dairy cow mammary epithelial cells.
Autorzy:: Yu W; Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin, P. R. China.
Guo J; Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin, P. R. China.
Mao L; College of Life Sciences, Shihezi University, Shihezi, P. R. China.
Wang Q; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.
Liu Y; Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin, P. R. China.
Xu D; Harbin Weike Biotechnology Co., Ltd, Harbin Veterinary Research Institute, CAAS, Harbin, P. R. China.
Ma J; Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin, P. R. China.; Harbin Weike Biotechnology Co., Ltd, Harbin Veterinary Research Institute, CAAS, Harbin, P. R. China.
Luo C; Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin, P. R. China.; Taizhou Key Laboratory of Minimally Invasive Interventional Therapy & Artificial Intelligence, Taizhou Branch of Zhejiang Cancer Hospital (Taizhou Cancer Hospital), Taizhou, Zhejiang, China.; Pokaż więcej
Źródło:: Animal biotechnology [Anim Biotechnol] 2023 Dec; Vol. 34 (8), pp. 3808-3818. Date of Electronic Publication: 2023 Jul 12.
Typ publikacji:: Journal Article
MeSH Terms:: Caseins*
Activating Transcription Factor 4*/metabolism
Female ; Cattle ; Animals ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Glucose/pharmacology ; Glucose/metabolism ; Mammary Glands, Animal/metabolism ; Epithelial Cells/metabolism

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Skocz do pozycji: 15.

Tytuł:: FARSB Facilitates Hepatocellular Carcinoma Progression by Activating the mTORC1 Signaling Pathway.
Autorzy:: Wang Y; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wang G; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Hu S; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yin C; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhao P; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhou X; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Shao S; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Liu R; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Hu W; School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Liu GL; School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Ke W; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Song Z; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 24; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 24.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Hepatocellular*/metabolism
Liver Neoplasms*/metabolism
Humans ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Cell Proliferation/genetics ; Cell Line, Tumor

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Skocz do pozycji: 16.

Tytuł:: Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses.
Autorzy:: Honoré E; Department of Neurosciences, Center for Interdisciplinary Research on Brain and Learning (CIRCA) and Research Group on Neural Signaling and Circuitry (GRSNC), Université de Montréal, P.O. Box 6128, Station Downtown, QC, H3C 3J7, Montreal, Canada.
Lacaille JC; Department of Neurosciences, Center for Interdisciplinary Research on Brain and Learning (CIRCA) and Research Group on Neural Signaling and Circuitry (GRSNC), Université de Montréal, P.O. Box 6128, Station Downtown, QC, H3C 3J7, Montreal, Canada. .; Pokaż więcej
Źródło:: Molecular brain [Mol Brain] 2022 Dec 21; Vol. 15 (1), pp. 101. Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Long-Term Potentiation*/physiology
Mechanistic Target of Rapamycin Complex 1*/metabolism
Spatial Learning*/physiology
Animals ; Mice ; Hippocampus/metabolism ; Interneurons/metabolism ; Somatostatin/metabolism ; Synapses/metabolism

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Skocz do pozycji: 17.

Tytuł:: Hepatic Oleate Regulates Insulin-like Growth Factor-Binding Protein 1 Partially through the mTORC1-FGF21 Axis during High-Carbohydrate Feeding.
Autorzy:: O'Neill LM; Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
Phang YX; Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
Liu Z; Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
Lewis SA; Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
Aljohani A; College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11564, Saudi Arabia.; King Abdullah International Medical Research Center (KAIMRC), Riyadh 11564, Saudi Arabia.
McGahee A; Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
Wade G; Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
Kalyesubula M; Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
Simcox J; Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.; Department of Nutritional Sciences, University of Wisconsin-Madison, 1415 Linden Drive, Madison, WI 53706, USA.
Ntambi JM; Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.; Department of Nutritional Sciences, University of Wisconsin-Madison, 1415 Linden Drive, Madison, WI 53706, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 24; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:: Journal Article
MeSH Terms:: Mechanistic Target of Rapamycin Complex 1*/metabolism
Oleic Acid*/metabolism
Stearoyl-CoA Desaturase*/genetics
Stearoyl-CoA Desaturase*/metabolism
Insulin-Like Growth Factor Binding Protein 1*/metabolism
Animals ; Mice ; Insulin/metabolism ; Liver/metabolism ; Obesity/metabolism ; Dietary Carbohydrates/administration & dosage

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Tytuł:: Arginyltransferase 1 modulates p62-driven autophagy via mTORC1/AMPk signaling.
Autorzy:: Bonnet LV; Departamento de Química Biológica Ranwel Caputto, Universidad Nacional de Córdoba, Córdoba, Argentina. .; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), CIQUIBIC, Córdoba, Argentina. .
Palandri A; Departamento de Química Biológica Ranwel Caputto, Universidad Nacional de Córdoba, Córdoba, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), CIQUIBIC, Córdoba, Argentina.
Flores-Martin JB; Departamento de Química Biológica Ranwel Caputto, Universidad Nacional de Córdoba, Córdoba, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), CIQUIBIC, Córdoba, Argentina.
Hallak ME; Departamento de Química Biológica Ranwel Caputto, Universidad Nacional de Córdoba, Córdoba, Argentina. .; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), CIQUIBIC, Córdoba, Argentina. .; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Jan 31; Vol. 22 (1), pp. 87. Date of Electronic Publication: 2024 Jan 31.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Aminoacyltransferases*/genetics
Aminoacyltransferases*/metabolism
Ubiquitin/metabolism ; Autophagy ; Proteasome Endopeptidase Complex/metabolism ; Mechanistic Target of Rapamycin Complex 1 ; Protein Isoforms

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Tytuł:: Mobilization of cholesterol induces the transition from quiescence to growth in Caenorhabditis elegans through steroid hormone and mTOR signaling.
Autorzy:: Schmeisser K; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. .
Kaptan D; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Raghuraman BK; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Shevchenko A; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Rodenfels J; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Physics of Life (PoL), Technical University Dresden, Dresden, Germany.
Penkov S; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Faculty of Medicine, Technical University Dresden, Dresden, Germany.
Kurzchalia TV; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2024 Jan 24; Vol. 7 (1), pp. 121. Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Caenorhabditis elegans*/genetics
Steroids*
Animals ; Cholesterol ; Mechanistic Target of Rapamycin Complex 1 ; Hormones

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Tytuł:: Nuclear receptor subfamily 1 group D member 1 suppresses the proliferation, migration of adventitial fibroblasts, and vascular intimal hyperplasia via mammalian target of rapamycin complex 1/β-catenin pathway.
Autorzy:: Peng K; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China.; Department of Cardiovascular Medicine, General Hospital of Western Theater Command, Chengdu, China.
Wang M; Department of Cardiovascular Medicine, General Hospital of Western Theater Command, Chengdu, China.
Wang J; Central Sterile Supply Department, General Hospital of Western Theater Command, Chengdu, China.
Wang Q; Department of Cardiovascular Medicine, General Hospital of Western Theater Command, Chengdu, China.
Li; Department of Cardiovascular Medicine, General Hospital of Western Theater Command, Chengdu, China.
Sun X; Department of Cardiovascular Medicine, General Hospital of Western Theater Command, Chengdu, China.
Yang Y; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China.; Department of Cardiovascular Medicine, General Hospital of Western Theater Command, Chengdu, China.
Yang D; Department of Cardiovascular Medicine, General Hospital of Western Theater Command, Chengdu, China.; Pokaż więcej
Źródło:: Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2023 Dec 31; Vol. 45 (1), pp. 2178659.
Typ publikacji:: Journal Article
MeSH Terms:: beta Catenin*/metabolism
Muscle, Smooth, Vascular*
Nuclear Receptor Subfamily 1, Group D, Member 1*/metabolism
Cell Movement ; Cell Proliferation ; Cells, Cultured ; Fibroblasts ; Hyperplasia/metabolism ; Hyperplasia/pathology ; Ki-67 Antigen/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Myocytes, Smooth Muscle ; Neointima/genetics ; Neointima/metabolism ; Neointima/pathology ; TOR Serine-Threonine Kinases/metabolism

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