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Tytuł :
How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.
Autorzy :
Carlson GA; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.
Prusiner SB; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 04; Vol. 22 (9). Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease/*genetics
Amyloid beta-Peptides/*genetics
Prion Proteins/*genetics
Scrapie/*genetics
alpha-Synuclein/*genetics
tau Proteins/*genetics
Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/metabolism ; Animals ; Creutzfeldt-Jakob Syndrome/etiology ; Creutzfeldt-Jakob Syndrome/genetics ; Creutzfeldt-Jakob Syndrome/metabolism ; Creutzfeldt-Jakob Syndrome/pathology ; Frontotemporal Dementia/etiology ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/metabolism ; Frontotemporal Dementia/pathology ; Gene Expression ; Gerstmann-Straussler-Scheinker Disease/etiology ; Gerstmann-Straussler-Scheinker Disease/genetics ; Gerstmann-Straussler-Scheinker Disease/metabolism ; Gerstmann-Straussler-Scheinker Disease/pathology ; Humans ; Mice ; Mutation ; Parkinson Disease/etiology ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Prion Proteins/chemistry ; Prion Proteins/metabolism ; Prions ; Protein Folding ; Scrapie/etiology ; Scrapie/metabolism ; Scrapie/pathology ; Sheep ; alpha-Synuclein/chemistry ; alpha-Synuclein/metabolism ; tau Proteins/chemistry ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Histidine Tautomeric Effect on the Key Fragment R3 of Tau Protein from Atomistic Simulations.
Autorzy :
Li H; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Li N; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Tang Y; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Lee JY; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Jun 02; Vol. 12 (11), pp. 1983-1988. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
tau Proteins*/metabolism
Histidine ; Humans ; Molecular Dynamics Simulation ; Neurofibrillary Tangles/metabolism
Czasopismo naukowe
Tytuł :
Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models.
Autorzy :
McMurray L; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Macdonald JA; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Ramakrishnan NK; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Zhao Y; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Williamson DW; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Tietz O; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Zhou X; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Kealey S; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Fagan SG; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Smolek T; Axon Neuroscience R&D Services SE, Bratislava, Slovak Republic 811 02.
Cubinkova V; Axon Neuroscience R&D Services SE, Bratislava, Slovak Republic 811 02.
Žilka N; Axon Neuroscience R&D Services SE, Bratislava, Slovak Republic 811 02.
Spillantini MG; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Tolkovsky AM; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Goedert M; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Aigbirhio FI; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Jun 02; Vol. 12 (11), pp. 1885-1893. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/diagnostic imaging
tau Proteins*/metabolism
Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Mice ; Mice, Transgenic ; Neurofibrillary Tangles/metabolism ; Positron-Emission Tomography ; Rats ; Rats, Transgenic
Czasopismo naukowe
Tytuł :
Characterization of a Mouse Model of Alzheimer's Disease Expressing Aβ4-42 and Human Mutant Tau.
Autorzy :
Zampar S; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, D-37075 Göttingen, Germany.
Wirths O; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, D-37075 Göttingen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 14; Vol. 22 (10). Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Mutation*
Alzheimer Disease/*complications
Amyloid beta-Peptides/*metabolism
Memory Disorders/*etiology
Motor Disorders/*etiology
tau Proteins/*genetics
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Animals ; Behavior, Animal ; Female ; Humans ; Male ; Memory Disorders/metabolism ; Memory Disorders/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Motor Disorders/metabolism ; Motor Disorders/pathology ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Phosphorylation-Induced Structural Reorganization in Tau-Paired Helical Filaments.
Autorzy :
Rani L; Department of Chemistry, Indian Institute of Technology Gandhinagar, Gandhinagar 382355, Gujarat, India.
Mallajosyula SS; Department of Chemistry, Indian Institute of Technology Gandhinagar, Gandhinagar 382355, Gujarat, India.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 May 05; Vol. 12 (9), pp. 1621-1631. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/metabolism
tau Proteins*/metabolism
Humans ; Neurofibrillary Tangles/metabolism ; Phosphorylation ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł :
Tau internalization: A complex step in tau propagation.
Autorzy :
Zhao J; Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, PR China.
Wu H; Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang, PR China.
Tang XQ; Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, PR China. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 May; Vol. 67, pp. 101272. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Tauopathies*
tau Proteins*/metabolism
Brain/metabolism ; Endocytosis ; Humans
Czasopismo naukowe
Tytuł :
Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction.
Autorzy :
Teravskis PJ; Department of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA.; School of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA.
Oxnard BR; College of Biological Sciences, University of Minnesota, Minneapolis, MN, 55455, USA.
Miller EC; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA.
Kemper L; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.
Ashe KH; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.; N. Bud Grossman Center for Memory Research and Care, Minneapolis, MN, 55455, USA.; GRECC, Minneapolis VA Medical Center, Minneapolis, MN, 55417, USA.
Liao D; Department of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA.
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Źródło :
The Journal of physiology [J Physiol] 2021 May; Vol. 599 (9), pp. 2483-2498. Date of Electronic Publication: 2019 Jul 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
tau Proteins*
Animals ; Cells, Cultured ; Neurons/metabolism ; Phosphorylation ; Rats
Czasopismo naukowe
Tytuł :
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.
Autorzy :
Subramanian M; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, Korea.; Convergence Research Center of Dementia, KIST, Seoul, Korea.
Hyeon SJ; Center for Neuroscience, Brain Science Institute, KIST, Seoul, Korea.
Das T; Biomedical Research Institute, KIST, Seoul, Korea.
Suh YS; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, Korea.
Kim YK; Convergence Research Center of Dementia, KIST, Seoul, Korea.
Lee JS; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, Korea.; Convergence Research Center of Dementia, KIST, Seoul, Korea.
Song EJ; Graduate School of Pharmaceutical Sciences and College of Pharmacy, Ewha Womans University, Seoul, Korea. .
Ryu H; Center for Neuroscience, Brain Science Institute, KIST, Seoul, Korea. .
Yu K; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, Korea. .; Convergence Research Center of Dementia, KIST, Seoul, Korea. .; Department of Functional Genomics, UST, Daejeon, Korea. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 02; Vol. 12 (1), pp. 3291. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*genetics
Drosophila Proteins/*genetics
MicroRNAs/*genetics
Ubiquitin-Protein Ligases/*genetics
tau Proteins/*genetics
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Autophagy/genetics ; Brain/metabolism ; Brain/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Eye/metabolism ; Eye/pathology ; Humans ; Lysosomes/metabolism ; Mice ; MicroRNAs/metabolism ; Neurons/metabolism ; Neurons/pathology ; Phosphorylation ; Proteasome Endopeptidase Complex/metabolism ; Protein Processing, Post-Translational ; Proteolysis ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology.
Autorzy :
Lee SH; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Meilandt WJ; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: .
Xie L; Department of Biomedical Imaging, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Gandham VD; Department of Biomedical Imaging, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Ngu H; Department of (3)Pathology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Barck KH; Department of Biomedical Imaging, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Rezzonico MG; Department of Bioinformatics and Computational Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Imperio J; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Lalehzadeh G; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Huntley MA; Department of Bioinformatics and Computational Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Stark KL; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Foreman O; Department of (3)Pathology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Carano RAD; Department of Biomedical Imaging, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Friedman BA; Department of Bioinformatics and Computational Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Sheng M; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Easton A; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Bohlen CJ; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Hansen DV; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2021 Apr 21; Vol. 109 (8), pp. 1283-1301.e6. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*metabolism
Amyloid/*metabolism
Amyloid beta-Protein Precursor/*metabolism
Brain/*metabolism
Membrane Glycoproteins/*metabolism
Receptors, Immunologic/*metabolism
tau Proteins/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Animals ; Atrophy/genetics ; Atrophy/metabolism ; Atrophy/pathology ; Brain/pathology ; Disease Models, Animal ; Membrane Glycoproteins/genetics ; Mice ; Mice, Transgenic ; Receptors, Immunologic/genetics ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.
Autorzy :
Caballero B; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.; Roche Chile Pharmaceuticals, Las Condes, Region Metropolitana, Chile.
Bourdenx M; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.; Institut des Maladies Neurodégénératives, CNRS, Université de Bordeaux, Bordeaux, France.
Luengo E; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute Teofilo Hernando for Drug Discovery, Department of Pharmacology, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain.; Instituto de Investigación Biosanitaria Hospital de la Princesa, Madrid, Spain.
Diaz A; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
Sohn PD; Helen and Robert Appel Alzheimer's Disease Research Institute, Weill Cornell Medicine, New York, NY, USA.
Chen X; Helen and Robert Appel Alzheimer's Disease Research Institute, Weill Cornell Medicine, New York, NY, USA.
Wang C; Helen and Robert Appel Alzheimer's Disease Research Institute, Weill Cornell Medicine, New York, NY, USA.
Juste YR; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
Wegmann S; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Patel B; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
Young ZT; Institute for Neurodegenerative Disease, University of California at San Francisco, San Francisco, CA, USA.
Kuo SY; Institute for Neurodegenerative Disease, University of California at San Francisco, San Francisco, CA, USA.
Rodriguez-Navarro JA; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.; Instituto Ramón y Cajal de Investigaciones Sanitarias Hospital Ramón y Cajal, Madrid, Spain.
Shao H; Institute for Neurodegenerative Disease, University of California at San Francisco, San Francisco, CA, USA.
Lopez MG; Institute Teofilo Hernando for Drug Discovery, Department of Pharmacology, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain.; Instituto de Investigación Biosanitaria Hospital de la Princesa, Madrid, Spain.
Karch CM; Department of Psychiatry, Washington University, St. Louis, MO, USA.
Goate AM; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gestwicki JE; Institute for Neurodegenerative Disease, University of California at San Francisco, San Francisco, CA, USA.
Hyman BT; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gan L; Helen and Robert Appel Alzheimer's Disease Research Institute, Weill Cornell Medicine, New York, NY, USA.
Cuervo AM; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA. .; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 14; Vol. 12 (1), pp. 2238. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chaperone-Mediated Autophagy*
Tauopathies/*metabolism
tau Proteins/*metabolism
Acetylation ; Animals ; Brain/metabolism ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism ; Tauopathies/genetics ; Tauopathies/pathology ; Tauopathies/physiopathology ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Association of Digital Clock Drawing With PET Amyloid and Tau Pathology in Normal Older Adults.
Autorzy :
Rentz DM; From the Department of Neurology (D.M.R., K.V.P., D.V.M., J.S.S., H.K., R.A.S., K.A.J.) and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School; Center for Alzheimer Research and Treatment, Department of Neurology (D.M.R., K.V.P., R.A.S., K.A.J.), Brigham and Women's Hospital, Harvard Medical School, Boston; Digital Cognition Technologies (W.S.-M.); and Linus Health Inc (W.S.-M.), Waltham, MA. .
Papp KV; From the Department of Neurology (D.M.R., K.V.P., D.V.M., J.S.S., H.K., R.A.S., K.A.J.) and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School; Center for Alzheimer Research and Treatment, Department of Neurology (D.M.R., K.V.P., R.A.S., K.A.J.), Brigham and Women's Hospital, Harvard Medical School, Boston; Digital Cognition Technologies (W.S.-M.); and Linus Health Inc (W.S.-M.), Waltham, MA.
Mayblyum DV; From the Department of Neurology (D.M.R., K.V.P., D.V.M., J.S.S., H.K., R.A.S., K.A.J.) and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School; Center for Alzheimer Research and Treatment, Department of Neurology (D.M.R., K.V.P., R.A.S., K.A.J.), Brigham and Women's Hospital, Harvard Medical School, Boston; Digital Cognition Technologies (W.S.-M.); and Linus Health Inc (W.S.-M.), Waltham, MA.
Sanchez JS; From the Department of Neurology (D.M.R., K.V.P., D.V.M., J.S.S., H.K., R.A.S., K.A.J.) and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School; Center for Alzheimer Research and Treatment, Department of Neurology (D.M.R., K.V.P., R.A.S., K.A.J.), Brigham and Women's Hospital, Harvard Medical School, Boston; Digital Cognition Technologies (W.S.-M.); and Linus Health Inc (W.S.-M.), Waltham, MA.
Klein H; From the Department of Neurology (D.M.R., K.V.P., D.V.M., J.S.S., H.K., R.A.S., K.A.J.) and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School; Center for Alzheimer Research and Treatment, Department of Neurology (D.M.R., K.V.P., R.A.S., K.A.J.), Brigham and Women's Hospital, Harvard Medical School, Boston; Digital Cognition Technologies (W.S.-M.); and Linus Health Inc (W.S.-M.), Waltham, MA.
Souillard-Mandar W; From the Department of Neurology (D.M.R., K.V.P., D.V.M., J.S.S., H.K., R.A.S., K.A.J.) and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School; Center for Alzheimer Research and Treatment, Department of Neurology (D.M.R., K.V.P., R.A.S., K.A.J.), Brigham and Women's Hospital, Harvard Medical School, Boston; Digital Cognition Technologies (W.S.-M.); and Linus Health Inc (W.S.-M.), Waltham, MA.
Sperling RA; From the Department of Neurology (D.M.R., K.V.P., D.V.M., J.S.S., H.K., R.A.S., K.A.J.) and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School; Center for Alzheimer Research and Treatment, Department of Neurology (D.M.R., K.V.P., R.A.S., K.A.J.), Brigham and Women's Hospital, Harvard Medical School, Boston; Digital Cognition Technologies (W.S.-M.); and Linus Health Inc (W.S.-M.), Waltham, MA.
Johnson KA; From the Department of Neurology (D.M.R., K.V.P., D.V.M., J.S.S., H.K., R.A.S., K.A.J.) and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School; Center for Alzheimer Research and Treatment, Department of Neurology (D.M.R., K.V.P., R.A.S., K.A.J.), Brigham and Women's Hospital, Harvard Medical School, Boston; Digital Cognition Technologies (W.S.-M.); and Linus Health Inc (W.S.-M.), Waltham, MA.
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Źródło :
Neurology [Neurology] 2021 Apr 06; Vol. 96 (14), pp. e1844-e1854. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amyloid beta-Peptides*
Neuropsychological Tests*
tau Proteins*
Brain/*pathology
Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Cognitive Dysfunction/diagnosis ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography
Czasopismo naukowe
Tytuł :
Inhibition of tau aggregation and associated cytotoxicity on neuron-like cells by calycosin.
Autorzy :
Zhenxia Z; School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou 521041, Guangdong, China.
Min L; School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou 521041, Guangdong, China.
Peikui Y; School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou 521041, Guangdong, China.
Zikai C; School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou 521041, Guangdong, China.
Yaqun L; School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou 521041, Guangdong, China.
Junli W; Center of Reproductive Medicine, Affiliated Hospital of Youjiang Medical University For Nationalities, Baise 533000, Guangxi, China.
Fenlian Y; School of Pharmacy, Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China. Electronic address: .
Yuzhong Z; School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou 521041, Guangdong, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Feb 28; Vol. 171, pp. 74-81. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article
MeSH Terms :
Isoflavones/*pharmacology
Neurons/*drug effects
Neuroprotective Agents/*pharmacology
Protein Aggregates/*drug effects
tau Proteins/*chemistry
Caspase 3/genetics ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Gene Expression Regulation ; HEK293 Cells ; Humans ; L-Lactate Dehydrogenase/metabolism ; Neurons/pathology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Reactive Oxygen Species/antagonists & inhibitors ; Reactive Oxygen Species/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; tau Proteins/genetics ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice.
Autorzy :
Walker CK; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, United States.
Greathouse KM; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, United States.
Boros BD; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, United States.
Poovey EH; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, United States.
Clearman KR; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, United States.
Ramdas R; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, United States.
Muhammad HM; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, United States.
Herskowitz JH; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, United States. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2021 Feb 10; Vol. 455, pp. 195-211. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Alzheimer Disease*
Dendritic Spines*/metabolism
Tauopathies*
tau Proteins*/genetics
tau Proteins*/metabolism
Animals ; Disease Models, Animal ; Hippocampus/metabolism ; Mice ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Interplay of isoform 1N4R tau protein and amyloid-β peptide fragment 25-35 in reducing and non-reducing conditions.
Autorzy :
Mohammadi F; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Jalal AleAhmad Highway, P.O.Box: 14115-111, Iran.
Takalloo Z; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Jalal AleAhmad Highway, P.O.Box: 14115-111, Iran.
Rahmani H; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Jalal AleAhmad Highway, P.O.Box: 14115-111, Iran.
Nasiri Khalili MA; Department of Bioscience and Biotechnology, Malek Ashtar University of Technology, Tehran, Lavizan, Babaei Highway, P.O.Box: 15875-1774, Iran.
Khajeh K; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Jalal AleAhmad Highway, P.O.Box: 14115-111, Iran.
Riazi G; Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Enghelab Square, Postal Code: 1417466191, Iran.
H Sajedi R; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Jalal AleAhmad Highway, P.O.Box: 14115-111, Iran.
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Źródło :
Journal of biochemistry [J Biochem] 2021 Feb 06; Vol. 169 (1), pp. 119-134.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*metabolism
Peptide Fragments/*metabolism
tau Proteins/*metabolism
Alzheimer Disease/pathology ; Amyloid beta-Peptides/chemistry ; Cell Survival ; Chromatography, Agarose/methods ; Circular Dichroism/methods ; Humans ; Microscopy, Atomic Force ; Nitrilotriacetic Acid/metabolism ; Oxidative Stress ; Peptide Fragments/chemistry ; Protein Aggregates ; Protein Aggregation, Pathological/metabolism ; Protein Isoforms/metabolism ; Spectrum Analysis/methods ; tau Proteins/chemistry ; tau Proteins/isolation & purification
Czasopismo naukowe
Tytuł :
The Two Cysteines of Tau Protein Are Functionally Distinct and Contribute Differentially to Its Pathogenicity in Vivo .
Autorzy :
Prifti E; Institute for Fundamental Biomedical Research.
Tsakiri EN; Institute for Fundamental Biomedical Research.
Vourkou E; Institute for Fundamental Biomedical Research.
Stamatakis G; Institute for Bio-innovation, Biomedical Sciences Research Centre 'Alexander Fleming,' Vari, 16672, Greece.
Samiotaki M; Institute for Bio-innovation, Biomedical Sciences Research Centre 'Alexander Fleming,' Vari, 16672, Greece.
Papanikolopoulou K; Institute for Fundamental Biomedical Research .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Jan 27; Vol. 41 (4), pp. 797-810. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cysteine/*metabolism
Tauopathies/*metabolism
Tauopathies/*pathology
tau Proteins/*metabolism
Aging/metabolism ; Alanine/metabolism ; Amino Acid Substitution ; Animals ; Animals, Genetically Modified ; Behavior, Animal ; Drosophila ; Epitopes ; Female ; Humans ; Male ; Microtubules/metabolism ; Mutation/genetics ; Phosphorylation ; tau Proteins/chemistry ; tau Proteins/toxicity
Czasopismo naukowe
Tytuł :
Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau.
Autorzy :
Lin Y; Biomolecular Science and Engineering, University of California, Santa Barbara, CA 93106, United States.
Fichou Y; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, United States.
Longhini AP; Molecular, Cell and Developmental Biology, University of California, Santa Barbara, CA 93106, United States.
Llanes LC; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, United States; Center for Polymers and Organic Solids, University of California, Santa Barbara, CA 93106, United States.
Yin P; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, United States.
Bazan GC; Departments of Chemistry and Chemical Engineering, National University of Singapore, 117543, Singapore.
Kosik KS; Molecular, Cell and Developmental Biology, University of California, Santa Barbara, CA 93106, United States; Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, United States.
Han S; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, United States; Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, United States. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jan 22; Vol. 433 (2), pp. 166731. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Hydrophobic and Hydrophilic Interactions*
Liquid-Liquid Extraction*/methods
Amyloid/*chemistry
tau Proteins/*chemistry
tau Proteins/*isolation & purification
Amyloid/metabolism ; Amyloid/ultrastructure ; Humans ; Protein Aggregates ; Protein Aggregation, Pathological ; Spectrum Analysis ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Disease-Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates.
Autorzy :
Savastano A; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075, Göttingen, Germany.
Flores D; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075, Göttingen, Germany.
Kadavath H; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075, Göttingen, Germany.
Biernat J; German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, 53127, Bonn, Germany.; Research Center CAESAR, Ludwig-Erhard-Allee 2, 53175, Bonn, Germany.
Mandelkow E; German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, 53127, Bonn, Germany.; Research Center CAESAR, Ludwig-Erhard-Allee 2, 53175, Bonn, Germany.
Zweckstetter M; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075, Göttingen, Germany.; Max Planck Institute for Biophysical Chemistry, Am Faßberg 11, 37077, Göttingen, Germany.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Jan 11; Vol. 60 (2), pp. 726-730. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Tubulin/*metabolism
tau Proteins/*metabolism
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Humans ; Microscopy, Fluorescence ; Mutagenesis, Site-Directed ; Nuclear Magnetic Resonance, Biomolecular ; Phosphorylation ; Protein Binding ; Tubulin/chemistry ; tau Proteins/chemistry ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Amyloid, tau and risk of Alzheimer's disease: a Mendelian randomization study.
Autorzy :
Yeung CHC; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Lau KWD; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Au Yeung SL; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Schooling CM; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong SAR, China. .; Graduate School of Public Health and Health Policy, City University of New York, New York, USA. .
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Źródło :
European journal of epidemiology [Eur J Epidemiol] 2021 Jan; Vol. 36 (1), pp. 81-88. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*diagnosis
Amyloid beta-Peptides/*genetics
tau Proteins/*metabolism
Aged ; Alzheimer Disease/blood ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/genetics ; Amplified Fragment Length Polymorphism Analysis ; Amyloid beta-Peptides/cerebrospinal fluid ; Amyloid beta-Peptides/metabolism ; Biomarkers/blood ; Female ; Genome-Wide Association Study ; Humans ; Male ; Mendelian Randomization Analysis ; Middle Aged ; Peptide Fragments ; Polymorphism, Single Nucleotide ; tau Proteins/blood ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Tytuł :
α-Linolenic acid inhibits Tau aggregation and modulates Tau conformation.
Autorzy :
Desale SE; Neurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, 411008 Pune, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Dubey T; Neurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, 411008 Pune, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Chinnathambi S; Neurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, 411008 Pune, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jan 01; Vol. 166, pp. 687-693. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Multimerization/*drug effects
alpha-Linolenic Acid/*pharmacology
tau Proteins/*chemistry
Humans ; Protein Conformation ; Protein Unfolding/drug effects ; alpha-Linolenic Acid/chemistry ; tau Proteins/metabolism
Czasopismo naukowe

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