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Tytuł:
Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau.
Autorzy:
Schweighauser M; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Murzin AG; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Macdonald J; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Lavenir I; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Crowther RA; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Scheres SHW; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. .
Goedert M; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Oct 05; Vol. 11 (1), pp. 160. Date of Electronic Publication: 2023 Oct 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
tau Proteins*/metabolism
Tauopathies*/metabolism
Humans ; Mice ; Animals ; Cryoelectron Microscopy ; Mice, Transgenic ; Brain/metabolism ; Cytoskeleton/metabolism ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models.
Autorzy:
Basheer N; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10, Bratislava, Slovakia.
Buee L; Inserm, CHU Lille, CNRS, LilNCog - Lille Neuroscience & Cognition, University of Lille, 59000, Lille, France. .
Brion JP; Faculty of Medicine, Laboratory of Histology, Alzheimer and Other Tauopathies Research Group (CP 620), ULB Neuroscience Institute (UNI), Université Libre de Bruxelles, 808, Route de Lennik, 1070, Brussels, Belgium.
Smolek T; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10, Bratislava, Slovakia.
Muhammadi MK; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10, Bratislava, Slovakia.
Hritz J; CEITEC Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.; Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 62500, Brno, Czech Republic.
Hromadka T; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10, Bratislava, Slovakia.
Dewachter I; Biomedical Research Institute, BIOMED, Hasselt University, 3500, Hasselt, Belgium.
Wegmann S; German Center for Neurodegenerative Diseases, Charitéplatz 1, 10117, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Landrieu I; CNRS EMR9002 - BSI - Integrative Structural Biology, 59000, Lille, France.; Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, University of Lille, 59000, Lille, France.
Novak P; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10, Bratislava, Slovakia.
Mudher A; School of Biological Sciences, Faculty of Environment and Life Sciences, University of Southampton, Highfield Campus, Southampton, SO17 1BJ, UK.
Zilka N; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10, Bratislava, Slovakia. .; AXON Neuroscience R&D Services SE, Dubravska Cesta 9, 845 10, Bratislava, Slovakia. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Apr 04; Vol. 12 (1), pp. 52. Date of Electronic Publication: 2024 Apr 04.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Alzheimer Disease*/pathology
Tauopathies*/pathology
Animals ; Neurofibrillary Tangles/pathology ; Disease Models, Animal ; tau Proteins/metabolism ; Brain/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer's disease and other neurodegenerative diseases.
Autorzy:
Kurihara M; Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.; Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.; Integrated Research Initiative for Living Well with Dementia, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Matsubara T; Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.; Department of Neurology, Tokushima University Hospital, Tokushima, Japan.
Morimoto S; Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.; Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.; Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
Arakawa A; Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Ohse K; Integrated Research Initiative for Living Well with Dementia, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Kanemaru K; Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Iwata A; Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.; Integrated Research Initiative for Living Well with Dementia, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Murayama S; Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.; Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.; Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, United Graduate School of Child Development, Osaka University, Osaka, Japan.
Saito Y; Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Mar 27; Vol. 12 (1), pp. 48. Date of Electronic Publication: 2024 Mar 27.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/pathology
Neurodegenerative Diseases*
Humans ; Female ; Male ; Retrospective Studies ; tau Proteins/cerebrospinal fluid ; Amyloid beta-Peptides/cerebrospinal fluid ; Amyloid ; Biomarkers/cerebrospinal fluid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer's disease: implications for biomarker development and therapeutic targeting.
Autorzy:
Rizzi L; Memory and Aging Center, Department of Neurology, Sandler Neurosciences Center, University of California San Francisco, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA.; Department of Neurology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Grinberg LT; Memory and Aging Center, Department of Neurology, Sandler Neurosciences Center, University of California San Francisco, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA. .; Department of Pathology, LIM-22, University of São Paulo Medical School, São Paulo, SP, Brazil. .; Department of Pathology, University of California San Francisco, San Francisco, CA, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 28; Vol. 12 (1), pp. 36. Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*/pathology
Tauopathies*/diagnosis
Tauopathies*/pathology
Humans ; tau Proteins/cerebrospinal fluid ; Caspases ; Biomarkers/cerebrospinal fluid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Astrocytic accumulation of tau fibrils isolated from Alzheimer's disease brains induces inflammation, cell-to-cell propagation and neuronal impairment.
Autorzy:
Eltom K; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden.
Mothes T; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden.
Libard S; Department of Immunology, Genetics and Pathology, Neuro-Oncology and Neurodegeneration, Uppsala University, Uppsala, Sweden.; Department of Pathology, Uppsala University Hospital, Uppsala, Sweden.
Ingelsson M; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden.; University Health Network, Krembil Brain Institute, Toronto, ON, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada.
Erlandsson A; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 26; Vol. 12 (1), pp. 34. Date of Electronic Publication: 2024 Feb 26.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/pathology
Humans ; Astrocytes/metabolism ; tau Proteins/metabolism ; Brain/pathology ; Neurons/metabolism ; Inflammation/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease.
Autorzy:
Raulin AC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Doss SV; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Heckman MG; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Craver EC; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Li Z; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Ikezu TC; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Sekiya H; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Liu CC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; Biogen, Cambridge, MA, 02142, USA.
Martens YA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; SciNeuro Pharmaceuticals, Rockville, MD, 20850, USA.
Rosenberg CL; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Kuchenbecker LA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
DeTure M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Reichard RR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Nguyen AT; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Constantopoulos E; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Larsen RA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Kounaves EK; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Bu G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Kanekiyo T; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 09; Vol. 12 (1), pp. 25. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/pathology
Apolipoproteins E*/genetics
Tauopathies*/pathology
Humans ; Amyloid ; Amyloid beta-Peptides ; Apolipoprotein E4/genetics ; tau Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue.
Autorzy:
Tauber CV; Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology, School of Medicine, Technical University Munich, Munich, Germany.; Department of Obstetrics and Gynecology, Ludiwgs-Maximilians University of Munich, Munich, Germany.
Schwarz SC; Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Rösler TW; Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology, School of Medicine, Technical University Munich, Munich, Germany.
Arzberger T; Center for Neuropathology and Prion Research, Ludwig-Maximilians University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians-University, Munich, Germany.
Gentleman S; Parkinson's UK Brain Bank, Department of Brain Sciences, Imperial College London, London, UK.; Neuropathology Unit, Department of Brain Sciences, Department of Medicine, Imperial College London, London, UK.
Windl O; Center for Neuropathology and Prion Research, Ludwig-Maximilians University of Munich, Munich, Germany.
Krumbiegel M; Institute of Human Genetics, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Reis A; Institute of Human Genetics, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Ruf VC; Center for Neuropathology and Prion Research, Ludwig-Maximilians University of Munich, Munich, Germany.
Herms J; Center for Neuropathology and Prion Research, Ludwig-Maximilians University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Höglinger GU; Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. .; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. .; Department of Neurology, Ludwig-Maximilians University of Munich, Munich, Germany. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Mar 11; Vol. 11 (1), pp. 40. Date of Electronic Publication: 2023 Mar 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease*
Parkinson Disease*/metabolism
tau Proteins*/genetics
Humans ; Brain/metabolism ; Genotype ; Haplotypes ; Polymorphism, Single Nucleotide ; RNA, Messenger/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies.
Autorzy:
Bathe T; Department of Pathology, Immunology & Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, 32610, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, 32610, USA.
Hery GP; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608, USA.
Villareal JAB; Department of Pathology, Immunology & Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, 32610, USA.
Phillips JL; Department of Pathology, Immunology & Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, 32610, USA.
Cohen EM; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, 32611, USA.
Sharma RV; Department of Pathology, Immunology & Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.
Tsering W; Department of Pathology, Immunology & Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, 32610, USA.; Department of Neuroscience, University of Florida, Gainesville, FL, 32610, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, 32610, USA.
Prokop S; Department of Pathology, Immunology & Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA. .; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, 32610, USA. .; Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, 32608, USA. .; McKnight Brain Institute, University of Florida, Gainesville, FL, 32610, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Apr 05; Vol. 12 (1), pp. 54. Date of Electronic Publication: 2024 Apr 05.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/pathology
Neurodegenerative Diseases*/pathology
Lewy Body Disease*/pathology
Animals ; Humans ; tau Proteins/metabolism ; alpha-Synuclein/metabolism ; Amyloid beta-Peptides/metabolism ; Brain/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Nuclear face of Tau: an inside player in neurodegeneration.
Autorzy:
Younas N; University Medical Center Göttingen, National Reference Center for Surveillance of TSE, Department of Neurology, Robert-Koch strasse 40, 37075, Göttingen, Germany. .; German Center for Neurodegenerative Diseases (DZNE), Göttingen, 37075, Germany. .
Saleem T; University Medical Center Göttingen, National Reference Center for Surveillance of TSE, Department of Neurology, Robert-Koch strasse 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Göttingen, 37075, Germany.
Younas A; University Medical Center Göttingen, National Reference Center for Surveillance of TSE, Department of Neurology, Robert-Koch strasse 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Göttingen, 37075, Germany.
Zerr I; University Medical Center Göttingen, National Reference Center for Surveillance of TSE, Department of Neurology, Robert-Koch strasse 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Göttingen, 37075, Germany.
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Dec 12; Vol. 11 (1), pp. 196. Date of Electronic Publication: 2023 Dec 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*/metabolism
Tauopathies*/metabolism
Animals ; Humans ; tau Proteins/metabolism ; Microtubules/metabolism ; Tubulin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain.
Autorzy:
Frey B; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061, Ludwigshafen, Germany. .; Department of Neurology, Hannover Medical School, Hanover, Germany. .; Center for Systems Neuroscience, Hannover, Germany. .
Holzinger D; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061, Ludwigshafen, Germany.
Taylor K; AbbVie Bioresearch Center, Biotherapeutics and Genetic Medicine Technologies, Worcester, MA, USA.
Ehrnhoefer DE; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061, Ludwigshafen, Germany.
Striebinger A; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061, Ludwigshafen, Germany.
Biesinger S; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061, Ludwigshafen, Germany.
Gasparini L; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061, Ludwigshafen, Germany.
O'Neill MJ; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061, Ludwigshafen, Germany.
Wegner F; Department of Neurology, Hannover Medical School, Hanover, Germany.; Center for Systems Neuroscience, Hannover, Germany.
Barghorn S; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061, Ludwigshafen, Germany.
Höglinger GU; Department of Neurology, Hannover Medical School, Hanover, Germany.; Center for Systems Neuroscience, Hannover, Germany.; German Center for Neurodegenerative Diseases E.V. (DZNE), Munich, Germany.; Department of Neurology, LMU University Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany.
Heym RG; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061, Ludwigshafen, Germany. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Nov 14; Vol. 11 (1), pp. 181. Date of Electronic Publication: 2023 Nov 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/pathology
Supranuclear Palsy, Progressive*/pathology
Humans ; tau Proteins/metabolism ; Brain/pathology ; Cerebellum/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Accurate digital quantification of tau pathology in progressive supranuclear palsy.
Autorzy:
Pansuwan, Tanrada (AUTHOR)
Quaegebeur, Annelies (AUTHOR)
Kaalund, Sanne S. (AUTHOR)
Hidari, Eric (AUTHOR)
Briggs, Mayen (AUTHOR)
Rowe, James B. (AUTHOR)
Rittman, Timothy (AUTHOR)
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Źródło:
Acta Neuropathologica Communications. 11/9/2023, Vol. 11 Issue 1, p1-21. 21p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice.
Autorzy:
Yukawa K; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 02118, USA.
Yamamoto-Mcguire S; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 02118, USA.
Cafaro L; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 02118, USA.
Hong C; Ionis Pharmaceuticals, Carlsbad, CA, 92010, USA.
Kamme F; Ionis Pharmaceuticals, Carlsbad, CA, 92010, USA.
Ikezu T; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 02118, USA. .; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA. .; Regenerative Science Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, 55905, USA. .; Mayo Clinic Alzheimer's Disease Research Center, Rochester, MN, 55905, USA. .; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. .
Ikezu S; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 02118, USA. .; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Oct 19; Vol. 11 (1), pp. 166. Date of Electronic Publication: 2023 Oct 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Tauopathies*/metabolism
Alzheimer Disease*/pathology
Mice ; Animals ; Humans ; Oligonucleotides, Antisense/pharmacology ; tau Proteins/genetics ; tau Proteins/metabolism ; Phosphorylation ; Mice, Transgenic ; Hippocampus/pathology ; Entorhinal Cortex/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Histone acetylation in an Alzheimer's disease cell model promotes homeostatic amyloid-reducing pathways.
Autorzy:
Xu DC; Department of Cell and Developmental Biology, Perelman School of Medicine Philadelphia, Penn Institute of Epigenetics, Philadelphia, PA, 19104, USA.
Sas-Nowosielska H; Department of Cell and Developmental Biology, Perelman School of Medicine Philadelphia, Penn Institute of Epigenetics, Philadelphia, PA, 19104, USA.
Donahue G; Department of Cell and Developmental Biology, Perelman School of Medicine Philadelphia, Penn Institute of Epigenetics, Philadelphia, PA, 19104, USA.
Huang H; Department of Cell and Developmental Biology, Perelman School of Medicine Philadelphia, Penn Institute of Epigenetics, Philadelphia, PA, 19104, USA.
Pourshafie N; Department of Cell and Developmental Biology, Perelman School of Medicine Philadelphia, Penn Institute of Epigenetics, Philadelphia, PA, 19104, USA.
Good CR; Department of Cell and Developmental Biology, Perelman School of Medicine Philadelphia, Penn Institute of Epigenetics, Philadelphia, PA, 19104, USA.
Berger SL; Department of Cell and Developmental Biology, Perelman School of Medicine Philadelphia, Penn Institute of Epigenetics, Philadelphia, PA, 19104, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Jan 02; Vol. 12 (1), pp. 3. Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/pathology
Humans ; Histones/genetics ; Acetylation ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid/metabolism ; tau Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Determinants of astrocytic pathology in stem cell models of primary tauopathies.
Autorzy:
Fiock KL; Department of Pathology, University of Iowa, 25 S Grand Ave MRC-108-A, Iowa City, IA, 52240, USA.; Experimental Pathology Graduate Program, University of Iowa, Iowa City, IA, USA.; Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Hook JN; Department of Pathology, University of Iowa, 25 S Grand Ave MRC-108-A, Iowa City, IA, 52240, USA.; Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Hefti MM; Department of Pathology, University of Iowa, 25 S Grand Ave MRC-108-A, Iowa City, IA, 52240, USA. .; Experimental Pathology Graduate Program, University of Iowa, Iowa City, IA, USA. .; Carver College of Medicine, University of Iowa, Iowa City, IA, USA. .; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Oct 06; Vol. 11 (1), pp. 161. Date of Electronic Publication: 2023 Oct 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Tauopathies*/pathology
Supranuclear Palsy, Progressive*/pathology
Chronic Traumatic Encephalopathy*/pathology
Humans ; tau Proteins/genetics ; tau Proteins/metabolism ; Astrocytes/metabolism ; Brain/pathology ; Protein Isoforms/metabolism
Czasopismo naukowe
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Tytuł:
Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration.
Autorzy:
Giannini LA; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, 3015 GD, The Netherlands.
Mol MO; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, 3015 GD, The Netherlands.
Rajicic A; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, 3015 GD, The Netherlands.
van Buuren R; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, 3015 GD, The Netherlands.
Sarkar L; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, 3015 GD, The Netherlands.
Arezoumandan S; Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ohm DT; Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Irwin DJ; Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Rozemuller AJ; Department of Pathology, Amsterdam Neuroscience, Amsterdam University Medical Center, location VUmc, Amsterdam, 1081 HZ, The Netherlands.
van Swieten JC; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, 3015 GD, The Netherlands.
Seelaar H; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, 3015 GD, The Netherlands. .
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Corporate Authors:
Netherlands Brain Bank
Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Aug 02; Vol. 11 (1), pp. 126. Date of Electronic Publication: 2023 Aug 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Frontotemporal Lobar Degeneration*/genetics
Frontotemporal Lobar Degeneration*/pathology
Frontotemporal Dementia*/pathology
Alzheimer Disease*/pathology
Humans ; Aged ; Middle Aged ; tau Proteins/genetics ; tau Proteins/metabolism ; Gray Matter/pathology ; Gyrus Cinguli/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A heterozygous splicing variant IVS9-7A > T in intron 9 of the MAPT gene in a patient with right-temporal variant frontotemporal dementia with atypical 4 repeat tauopathy.
Autorzy:
Mori K; Department of Psychiatry, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, Japan. .
Shigenobu K; Department of Psychiatry, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, Japan.; Department of Psychiatry, Asakayama General Hospital, Sakai, Japan.; Department of Behavioral Neurology and Neuropsychiatry, United Graduate School of Child Development, Osaka University, Suita, Japan.
Beck G; Department of Neurology, Graduate School of Medicine, Osaka University, Suita, Japan.
Uozumi R; Department of Psychiatry, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, Japan.
Satake Y; Department of Psychiatry, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, Japan.
Suzuki M; Department of Behavioral Neurology and Neuropsychiatry, United Graduate School of Child Development, Osaka University, Suita, Japan.
Kondo S; Department of Psychiatry, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, Japan.
Gotoh S; Department of Psychiatry, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, Japan.
Yonenobu Y; Department of Neurology, Graduate School of Medicine, Osaka University, Suita, Japan.
Kawai M; Department of Pathology, Graduate School of Medicine, Osaka University, Suita, Japan.
Suzuki Y; Department of Psychiatry, Kansai Rosai Hospital, Amagasaki, Japan.
Saito Y; Brain Bank for Aging Research (Neuropathology), Tokyo Metropolitan Institute of Geriatrics and Gerontology, Tokyo, Japan.
Morii E; Department of Pathology, Graduate School of Medicine, Osaka University, Suita, Japan.
Hasegawa M; Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Mochizuki H; Department of Neurology, Graduate School of Medicine, Osaka University, Suita, Japan.
Murayama S; Department of Neurology, Graduate School of Medicine, Osaka University, Suita, Japan.; Brain Bank for Aging Research (Neuropathology), Tokyo Metropolitan Institute of Geriatrics and Gerontology, Tokyo, Japan.; Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Japan.
Ikeda M; Department of Psychiatry, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, Japan. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Aug 10; Vol. 11 (1), pp. 130. Date of Electronic Publication: 2023 Aug 10.
Typ publikacji:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aphasia, Primary Progressive*/pathology
Frontotemporal Dementia*/genetics
Frontotemporal Dementia*/pathology
Pick Disease of the Brain*/pathology
Tauopathies*/genetics
Tauopathies*/pathology
Humans ; Introns/genetics ; Mutation ; tau Proteins/genetics ; tau Proteins/metabolism ; Temporal Lobe/metabolism
Czasopismo naukowe
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Tytuł:
Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels.
Autorzy:
Wennström M; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Inga Marie Nilssons gata 53, 214 28, Malmö, Sweden. .
Janelidze S; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Inga Marie Nilssons gata 53, 214 28, Malmö, Sweden.
Nilsson KPR; Department of Physics, Chemistry and Biology IFM, Linköping University, 581 83, Linköping, Sweden.
Serrano GE; Banner Sun Health Research Institute, Sun City, AZ, USA.
Beach TG; Banner Sun Health Research Institute, Sun City, AZ, USA.
Dage JL; Eli Lilly and Company, Indianapolis, IN, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Inga Marie Nilssons gata 53, 214 28, Malmö, Sweden. .; Memory Clinic, Skåne University Hospital, Malmö, Sweden. .
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Corporate Authors:
Netherlands Brain Bank
Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2022 Jan 06; Vol. 10 (1), pp. 3. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*metabolism
Brain/*metabolism
Neurons/*metabolism
Tauopathies/*metabolism
tau Proteins/*metabolism
Aged ; Aged, 80 and over ; Alzheimer Disease/blood ; Alzheimer Disease/pathology ; Brain/pathology ; Female ; Humans ; Male ; Middle Aged ; Neurofibrillary Tangles/metabolism ; Neurofibrillary Tangles/pathology ; Neurons/pathology ; Phosphorylation ; Tauopathies/blood ; Tauopathies/pathology ; tau Proteins/blood
Czasopismo naukowe
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Tytuł:
Alterations in iron content, iron-regulatory proteins and behaviour without tau pathology at one year following repetitive mild traumatic brain injury.
Autorzy:
Juan SMA; Synaptic Neurobiology Laboratory, The Florey Institute of Neuroscience and Mental Health, The Melbourne Dementia Research Centre, The University of Melbourne, Kenneth Myer Building, 30 Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Daglas M; Synaptic Neurobiology Laboratory, The Florey Institute of Neuroscience and Mental Health, The Melbourne Dementia Research Centre, The University of Melbourne, Kenneth Myer Building, 30 Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Truong PH; Synaptic Neurobiology Laboratory, The Florey Institute of Neuroscience and Mental Health, The Melbourne Dementia Research Centre, The University of Melbourne, Kenneth Myer Building, 30 Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Mawal C; Synaptic Neurobiology Laboratory, The Florey Institute of Neuroscience and Mental Health, The Melbourne Dementia Research Centre, The University of Melbourne, Kenneth Myer Building, 30 Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
Adlard PA; Synaptic Neurobiology Laboratory, The Florey Institute of Neuroscience and Mental Health, The Melbourne Dementia Research Centre, The University of Melbourne, Kenneth Myer Building, 30 Royal Parade, Parkville, Melbourne, VIC, 3052, Australia. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Jul 18; Vol. 11 (1), pp. 118. Date of Electronic Publication: 2023 Jul 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Concussion*/pathology
Brain Injuries, Traumatic*/complications
Mice ; Animals ; Mice, Transgenic ; Iron ; Iron-Regulatory Proteins ; Mice, Inbred C57BL ; tau Proteins/metabolism ; Transcription Factors ; Disease Models, Animal
Czasopismo naukowe
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Tytuł:
Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology.
Autorzy:
Mothes T; Department of Public Health and Caring Sciences; Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, 752 37, Uppsala, Sweden.
Portal B; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Konstantinidis E; Department of Public Health and Caring Sciences; Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, 752 37, Uppsala, Sweden.
Eltom K; Department of Public Health and Caring Sciences; Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, 752 37, Uppsala, Sweden.
Libard S; Department of Immunology, Genetics and Pathology, Neuro-Oncology and Neurodegeneration, Uppsala University, Uppsala, Sweden.
Streubel-Gallasch L; Department of Public Health and Caring Sciences; Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, 752 37, Uppsala, Sweden.
Ingelsson M; Department of Public Health and Caring Sciences; Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, 752 37, Uppsala, Sweden.; University Health Network, Krembil Brain Institute, Toronto, Canada.; Department of Medicine and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.
Rostami J; Department of Public Health and Caring Sciences; Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, 752 37, Uppsala, Sweden.
Lindskog M; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Erlandsson A; Department of Public Health and Caring Sciences; Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, 752 37, Uppsala, Sweden. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Jun 17; Vol. 11 (1), pp. 97. Date of Electronic Publication: 2023 Jun 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tauopathies*/pathology
Alzheimer Disease*/pathology
Humans ; tau Proteins/metabolism ; Astrocytes/metabolism ; Neurons/metabolism ; Brain/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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