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Wyszukujesz frazę ""tau Proteins"" wg kryterium: Temat


Tytuł :
Theoretical Insights into Mutation and Histidine Tautomerism Effects on Tau Proteins.
Autorzy :
Li H; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Joo E; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Lee JY; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Nov 17; Vol. 12 (22), pp. 4361-4366. Date of Electronic Publication: 2021 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/genetics
tau Proteins*/genetics
tau Proteins*/metabolism
Histidine/genetics ; Humans ; Mutation/genetics ; Neurofibrillary Tangles/metabolism ; Protein Conformation, beta-Strand
Czasopismo naukowe
Tytuł :
Pretreatment with metformin prevents microcystin-LR-induced tau hyperphosphorylation via mTOR-dependent PP2A and GSK-3β activation.
Autorzy :
Zhang Y; Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, China.
Fan X; Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, China.
Su Z; Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, China.
Yuan T; Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, China.
Yin H; Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, China.
Gu H; Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, China.
Zuo Y; Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, China.
Chen S; Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, China.
Zhou H; Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou, China.
Su G; School of Pharmacy, Nantong University, Nantong, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Dec; Vol. 36 (12), pp. 2414-2425. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Metformin*/pharmacology
tau Proteins*/metabolism
Animals ; Glycogen Synthase Kinase 3 beta ; Marine Toxins ; Microcystins/toxicity ; Phosphorylation ; Protein Phosphatase 2/metabolism ; Rats ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Tytuł :
Chronic MC-LR exposure promoted Aβ and p-tau accumulation via regulating Akt/GSK-3β signal pathway.
Autorzy :
Ma Y; Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China.
Wang J; Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China.
Xu D; Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China.
Chen Y; Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China. Electronic address: .
Han X; Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Nov 10; Vol. 794, pp. 148732. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Proto-Oncogene Proteins c-akt*/metabolism
tau Proteins*/metabolism
Amyloid Precursor Protein Secretases ; Animals ; Aspartic Acid Endopeptidases ; Glycogen Synthase Kinase 3 ; Mice ; Signal Transduction
Czasopismo naukowe
Tytuł :
Dynamic-Inspired Perspective on the Molecular Inhibitor of Tau Aggregation by Glucose Gallates Based on Human Neurons.
Autorzy :
Hu Y; School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.
Yang D; Department of Medical Genetics, School of Medicine, Tongji University, Shanghai 200092, China.
Tu Y; School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.
Chai K; School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.
Chu L; Department of Medical Genetics, School of Medicine, Tongji University, Shanghai 200092, China.
Shi S; School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.
Yao T; School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Nov 03; Vol. 12 (21), pp. 4162-4174. Date of Electronic Publication: 2021 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
tau Proteins*
Glucose ; Humans ; Ligands ; Neurons
Czasopismo naukowe
Tytuł :
N-Amination Converts Amyloidogenic Tau Peptides into Soluble Antagonists of Cellular Seeding.
Autorzy :
Makwana KM; Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Sarnowski MP; Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Miao J; Department of Chemistry, Tufts University, Medford, Massachusetts 02155, United States.
Lin YS; Department of Chemistry, Tufts University, Medford, Massachusetts 02155, United States.
Del Valle JR; Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Oct 20; Vol. 12 (20), pp. 3928-3938. Date of Electronic Publication: 2021 Oct 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alzheimer Disease*
tau Proteins*/metabolism
Amination ; Humans ; Neurofibrillary Tangles/metabolism ; Peptides ; Protein Conformation, beta-Strand
Czasopismo naukowe
Tytuł :
Activity-dependent release of phosphorylated human tau from Drosophila neurons in primary culture.
Autorzy :
Ismael S; Neuroscience Program, Department of Biological Sciences, and Molecular and Cellular Biology Interdisciplinary Graduate Program, Ohio University, Athens, Ohio, USA.
Sindi G; Neuroscience Program, Department of Biological Sciences, and Molecular and Cellular Biology Interdisciplinary Graduate Program, Ohio University, Athens, Ohio, USA.
Colvin RA; Neuroscience Program, Department of Biological Sciences, and Molecular and Cellular Biology Interdisciplinary Graduate Program, Ohio University, Athens, Ohio, USA.
Lee D; Neuroscience Program, Department of Biological Sciences, and Molecular and Cellular Biology Interdisciplinary Graduate Program, Ohio University, Athens, Ohio, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101108. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation, Missense*
Alzheimer Disease/*metabolism
Neurons/*metabolism
tau Proteins/*metabolism
Alzheimer Disease/genetics ; Amino Acid Substitution ; Animals ; Cells, Cultured ; Drosophila melanogaster ; Humans ; Light ; Phosphorylation ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.
Autorzy :
Dai B; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China; Wuhan University Shenzhen Research Institute, Shenzhen, China.
Zhong T; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China; Wuhan University Shenzhen Research Institute, Shenzhen, China.
Chen ZX; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China; Wuhan University Shenzhen Research Institute, Shenzhen, China.
Chen W; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China; Wuhan University Shenzhen Research Institute, Shenzhen, China.
Zhang N; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China; Wuhan University Shenzhen Research Institute, Shenzhen, China.
Liu XL; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China; Wuhan University Shenzhen Research Institute, Shenzhen, China.
Wang LQ; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China; Wuhan University Shenzhen Research Institute, Shenzhen, China.
Chen J; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China; Wuhan University Shenzhen Research Institute, Shenzhen, China.
Liang Y; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China; Wuhan University Shenzhen Research Institute, Shenzhen, China. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101222. Date of Electronic Publication: 2021 Sep 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy/*drug effects
Autophagy-Related Protein 5/*metabolism
Flavonoids/*pharmacology
Protein Aggregates/*drug effects
Signal Transduction/*drug effects
tau Proteins/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Autophagy-Related Protein 5/genetics ; Cell Line, Tumor ; Humans ; Signal Transduction/genetics ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
Autorzy :
Nies SH; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, Connecticut, USA; Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany.
Takahashi H; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, Connecticut, USA.
Herber CS; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, Connecticut, USA.
Huttner A; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.
Chase A; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, Connecticut, USA.
Strittmatter SM; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, Connecticut, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101159. Date of Electronic Publication: 2021 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*metabolism
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*metabolism
Cerebral Cortex/*metabolism
Hippocampus/*metabolism
Neurites/*metabolism
tau Proteins/*metabolism
Aging/genetics ; Alzheimer Disease/genetics ; Amyloid beta-Peptides/genetics ; Animals ; Mice ; Mice, Knockout ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Phospho-Tau and Chromatin Landscapes in Early and Late Alzheimer's Disease.
Autorzy :
Gil L; Departamento de Genética, Escuela de Medicina, Universidad 'Alfonso X el Sabio', 28691 Madrid, Spain.
Niño SA; Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma, de San Luis Potosí 78210, Mexico.
Guerrero C; Banco de Cerebros (Biobanco), Hospital Universitario Fundación Alcorcón, Alcorcón, 28922 Madrid, Spain.
Jiménez-Capdeville ME; Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma, de San Luis Potosí 78210, Mexico.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 24; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease/*metabolism
Chromatin/*metabolism
tau Proteins/*metabolism
Alzheimer Disease/etiology ; Alzheimer Disease/genetics ; Chromatin/genetics ; DNA/chemistry ; DNA/genetics ; DNA/metabolism ; DNA Damage ; Epigenesis, Genetic ; Genomic Instability ; Histone Code ; Humans ; Nucleosomes/metabolism ; Phosphorylation ; Time Factors ; tau Proteins/chemistry ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation.
Autorzy :
Hou Z; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Wydorski PM; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.; Molecular Biophysics Program, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Perez VA; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.; Molecular Biophysics Program, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Mendoza-Oliva A; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Ryder BD; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.; Molecular Biophysics Program, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Mirbaha H; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Kashmer O; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Joachimiak LA; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States. .; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, United States. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 09; Vol. 12 (1), pp. 5338. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid/*chemistry
Heat-Shock Proteins/*chemistry
Molecular Chaperones/*chemistry
Protein Aggregates/*genetics
Tauopathies/*genetics
tau Proteins/*chemistry
Amyloid/antagonists & inhibitors ; Amyloid/genetics ; Amyloid/metabolism ; Animals ; Binding Sites ; Brain/metabolism ; Brain/pathology ; Cloning, Molecular ; Disease Models, Animal ; Gene Expression ; HEK293 Cells ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Humans ; Mice ; Models, Molecular ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Mutation ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Folding ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Substrate Specificity ; Tauopathies/metabolism ; Tauopathies/pathology ; Thermodynamics ; tau Proteins/genetics ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Tau N -Terminal Inserts Regulate Tau Liquid-Liquid Phase Separation and Condensates Maturation in a Neuronal Cell Model.
Autorzy :
Wu C; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
Zhao J; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
Wu Q; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
Tan Q; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
Liu Q; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
Xiao S; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 08; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article
MeSH Terms :
Liquid-Liquid Extraction*/methods
Neurons/*metabolism
tau Proteins/*chemistry
tau Proteins/*isolation & purification
Biomarkers ; Cell Line ; Fluorescent Antibody Technique ; Humans ; Protein Aggregates ; Protein Aggregation, Pathological/metabolism ; Protein Binding ; Protein Isoforms ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study.
Autorzy :
Thijssen EH; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, Netherlands.
La Joie R; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Strom A; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Fonseca C; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Iaccarino L; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Wolf A; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Spina S; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Allen IE; Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Cobigo Y; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Heuer H; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
VandeVrede L; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Proctor NK; Eli Lilly and Company, Indianapolis, IN, USA.
Lago AL; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Baker S; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Sivasankaran R; Novartis, Cambridge, MA, USA.
Kieloch A; Novartis, Cambridge, MA, USA.
Kinhikar A; Novartis, Cambridge, MA, USA.
Yu L; Novartis, Cambridge, MA, USA.
Valentin MA; Novartis, Cambridge, MA, USA.
Jeromin A; Quanterix, Billerica, MA, USA.
Zetterberg H; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK; UK Dementia Research Institute at UCL, University College London, London, UK.
Hansson O; Clinical Memory Research Unit, Lund University, Lund, Sweden.
Mattsson-Carlgren N; Clinical Memory Research Unit, Lund University, Lund, Sweden; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden; Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.
Graham D; Biogen, Cambridge, MA, USA.
Blennow K; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Kramer JH; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Grinberg LT; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Department of Pathology, University of California, San Francisco, CA, USA.
Seeley WW; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Department of Pathology, University of California, San Francisco, CA, USA.
Rosen H; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Miller BL; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, Netherlands.
Rabinovici GD; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Department of Radiology & Biomedical Imaging, University of California, San Francisco, CA, USA.
Rojas JC; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Dage JL; Eli Lilly and Company, Indianapolis, IN, USA.
Boxer AL; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Electronic address: .
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Corporate Authors :
Advancing Research and Treatment for Frontotemporal Lobar Degeneration investigators
Źródło :
The Lancet. Neurology [Lancet Neurol] 2021 Sep; Vol. 20 (9), pp. 739-752.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*diagnosis
Cognitive Dysfunction/*diagnosis
Frontotemporal Lobar Degeneration/*diagnosis
tau Proteins/*metabolism
Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/blood ; Alzheimer Disease/cerebrospinal fluid ; Amyloid beta-Peptides/metabolism ; Biomarkers/blood ; Cognitive Dysfunction/blood ; Cognitive Dysfunction/cerebrospinal fluid ; Diagnosis, Differential ; Female ; Frontotemporal Lobar Degeneration/blood ; Frontotemporal Lobar Degeneration/cerebrospinal fluid ; Humans ; Male ; Middle Aged ; Phosphorylation/physiology ; Positron-Emission Tomography ; Predictive Value of Tests ; Retrospective Studies ; tau Proteins/blood ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Tytuł :
Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau-microtubule interactions and inhibits aggregation.
Autorzy :
Xia Y; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, BMS J483/CTRND, 1275 Center Drive, Gainesville, FL, 32610, USA.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Bell BM; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, BMS J483/CTRND, 1275 Center Drive, Gainesville, FL, 32610, USA.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Giasson BI; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. .; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, BMS J483/CTRND, 1275 Center Drive, Gainesville, FL, 32610, USA. .; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. .
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Źródło :
Scientific reports [Sci Rep] 2021 Aug 23; Vol. 11 (1), pp. 17069. Date of Electronic Publication: 2021 Aug 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Multimerization*
Protein Processing, Post-Translational*
Microtubules/*metabolism
tau Proteins/*metabolism
Acetylation ; Amino Acid Motifs ; HEK293 Cells ; Humans ; Mutation ; Protein Binding ; tau Proteins/chemistry ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Hsp40s play complementary roles in the prevention of tau amyloid formation.
Autorzy :
Irwin R; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Faust O; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Petrovic I; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Wolf SG; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.
Hofmann H; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Rosenzweig R; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
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Źródło :
ELife [Elife] 2021 Aug 09; Vol. 10. Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HSP40 Heat-Shock Proteins/*metabolism
tau Proteins/*chemistry
tau Proteins/*metabolism
Amyloidogenic Proteins ; Escherichia coli ; HSP40 Heat-Shock Proteins/genetics ; Mutation ; Protein Aggregation, Pathological ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Evaluation of heptelidic acid as a potential inhibitor for tau aggregation-induced Alzheimer's disease and associated neurotoxicity.
Autorzy :
Zhang L; School of Nursing, Jinzhou Medical University, Jinzhou 121099, China.
Wang Z; School of Nursing, Jinzhou Medical University, Jinzhou 121099, China.
Yuan X; Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121099, China.
Sui R; Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121099, China. Electronic address: .
Falahati M; Department of Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jul 31; Vol. 183, pp. 1155-1161. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Neuroprotective Agents/*pharmacology
tau Proteins/*adverse effects
Animals ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Hydrophobic and Hydrophilic Interactions ; Mice ; Protein Aggregates/drug effects ; Protein Structure, Secondary ; Sesquiterpenes/pharmacology ; tau Proteins/chemistry ; tau Proteins/drug effects
Czasopismo naukowe
Tytuł :
Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils.
Autorzy :
Chakraborty P; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Rivière G; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Liu S; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
de Opakua AI; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Dervişoğlu R; Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Hebestreit A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Andreas LB; Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Vorberg IM; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
Zweckstetter M; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany. .; Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 09; Vol. 12 (1), pp. 4231. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid/*metabolism
Protein Aggregation, Pathological/*pathology
RNA/*metabolism
tau Proteins/*metabolism
Amyloid/ultrastructure ; Biosensing Techniques ; Humans ; Nuclear Magnetic Resonance, Biomolecular ; RNA/ultrastructure ; RNA, Fungal/metabolism ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Recombinant Proteins/ultrastructure ; tau Proteins/isolation & purification ; tau Proteins/ultrastructure
Czasopismo naukowe
Tytuł :
Intravenous administration of mesenchymal stem cells reduces Tau phosphorylation and inflammation in the 3xTg-AD mouse model of Alzheimer's disease.
Autorzy :
Neves AF; University of Miami Miller School of Medicine, Department of Neurology, 1420 NW 9th Avenue, Miami, FL 33136, United States of America. Electronic address: .
Camargo C; University of Miami Miller School of Medicine, Department of Neurology, 1150 Northwest 14th Street, Miami, FL 33136, United States of America. Electronic address: .
Premer C; Interdisciplinary Stem Cell Institute, Biomedical Research Building, 1501 NW 10th Avenue, Suite 909, Miami, FL 33136, United States of America. Electronic address: .
Hare JM; Interdisciplinary Stem Cell Institute, Biomedical Research Building, 1501 NW 10th Avenue, Suite 909, Miami, FL 33136, United States of America. Electronic address: .
Baumel BS; University of Miami Miller School of Medicine, Department of Neurology, 1150 Northwest 14th Street, Miami, FL 33136, United States of America. Electronic address: .
Pinto M; University of Miami Miller School of Medicine, Department of Neurology, 1420 NW 9th Avenue, Miami, FL 33136, United States of America. Electronic address: .
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Źródło :
Experimental neurology [Exp Neurol] 2021 Jul; Vol. 341, pp. 113706. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*metabolism
Alzheimer Disease/*therapy
Mesenchymal Stem Cell Transplantation/*methods
tau Proteins/*antagonists & inhibitors
tau Proteins/*metabolism
Administration, Intravenous ; Alzheimer Disease/genetics ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Animals ; Female ; Hippocampus/metabolism ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/therapy ; Mesenchymal Stem Cells ; Mice ; Mice, 129 Strain ; Mice, Transgenic ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Phosphorylation/physiology ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Tau in the gut, does it really matter?
Autorzy :
Derkinderen P; Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Université de Nantes, Nantes, France.; Department of Neurology, CHU Nantes, Nantes, France.
Rolli-Derkinderen M; Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Université de Nantes, Nantes, France.
Chapelet G; Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Université de Nantes, Nantes, France.; Clinical Gerontology Department, CHU Nantes, Nantes, France.
Neunlist M; Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Université de Nantes, Nantes, France.
Noble W; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK.
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Źródło :
Journal of neurochemistry [J Neurochem] 2021 Jul; Vol. 158 (2), pp. 94-104. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Enteric Nervous System/*metabolism
Tauopathies/*genetics
tau Proteins/*genetics
Animals ; Gastrointestinal Microbiome ; Humans ; Tauopathies/metabolism ; tau Proteins/metabolism ; tau Proteins/physiology
Czasopismo naukowe
Tytuł :
Non-Canonical Roles of Tau and Their Contribution to Synaptic Dysfunction.
Autorzy :
Siano G; Laboratory of Biology, BIO@SNS, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa, Italy.
Falcicchia C; Institute of Neuroscience, Italian National Research Council, Via Moruzzi 1, 56124 Pisa, Italy.
Origlia N; Institute of Neuroscience, Italian National Research Council, Via Moruzzi 1, 56124 Pisa, Italy.
Cattaneo A; Laboratory of Biology, BIO@SNS, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa, Italy.; European Brain Research Institute (EBRI), Fondazione Rita Levi-Montalcini, Viale Regina Elena 295, 00161 Roma, Italy.
Di Primio C; Institute of Neuroscience, Italian National Research Council, Via Moruzzi 1, 56124 Pisa, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 20; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Nucleus/*metabolism
Synapses/*metabolism
Tauopathies/*metabolism
tau Proteins/*metabolism
Active Transport, Cell Nucleus ; Animals ; Humans ; Synapses/physiology ; tau Proteins/chemistry
Czasopismo naukowe

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