Temat: "tau Proteins" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis.
Autorzy:: Terron HM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA.
Parikh SJ; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA.
Abdul-Hay SO; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Sahara T; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Kang D; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Dickson DW; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Saftig P; Institut für Biochemie, Christian-Albrechts-Universität zu Kiel, D-24098, Kiel, Germany.
LaFerla FM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA.; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, 92697, USA.
Lane S; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA.
Leissring MA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA. .; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA. .; Pokaż więcej
Źródło:: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Apr 04; Vol. 16 (1), pp. 70. Date of Electronic Publication: 2024 Apr 04.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease*/pathology
Tauopathies*/genetics
Tauopathies*/metabolism
Aged ; Animals ; Humans ; Mice ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Cathepsin D ; Disease Models, Animal ; Mice, Knockout ; Mice, Transgenic ; tau Proteins/genetics ; tau Proteins/metabolism

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Skocz do pozycji: 2.

Tytuł:: Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies.
Autorzy:: Olešová D; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 845 10, Slovak Republic.
Dobešová D; Laboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, Zdravotníků 7, Olomouc, 779 00, Czech Republic.
Majerová P; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 845 10, Slovak Republic.
Brumarová R; Laboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, Zdravotníků 7, Olomouc, 779 00, Czech Republic.
Kvasnička A; Laboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, Zdravotníků 7, Olomouc, 779 00, Czech Republic.
Kouřil Š; Laboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, Zdravotníků 7, Olomouc, 779 00, Czech Republic.
Stevens E; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 845 10, Slovak Republic.
Hanes J; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 845 10, Slovak Republic.
Fialová Ľ; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 845 10, Slovak Republic.
Michalicová A; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 845 10, Slovak Republic.
Piešťanský J; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 845 10, Slovak Republic.
Šinský J; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 845 10, Slovak Republic.
Kaňovský P; Department of Neurology, University Hospital Olomouc, Zdravotníků 7, Olomouc, 779 00, Czech Republic.; Department of Neurology, Palacky University, Zdravotníků 7, Olomouc, 779 00, Czech Republic.
Friedecký D; Laboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, Zdravotníků 7, Olomouc, 779 00, Czech Republic. .
Kováč A; Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 845 10, Slovak Republic. .; Pokaż więcej
Źródło:: Journal of neuroinflammation [J Neuroinflammation] 2024 Mar 27; Vol. 21 (1), pp. 78. Date of Electronic Publication: 2024 Mar 27.
Typ publikacji:: Journal Article
MeSH Terms:: Tauopathies*/pathology
Alzheimer Disease*/pathology
Rats ; Animals ; Mice ; tau Proteins/genetics ; tau Proteins/metabolism ; Neurofibrillary Tangles/metabolism ; Lipid Metabolism ; Brain/metabolism ; Rats, Transgenic ; Mice, Transgenic ; Disease Models, Animal

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Skocz do pozycji: 3.

Tytuł:: The Chronic Effects of a Single Low-Intensity Blast Exposure on Phosphoproteome Networks and Cognitive Function Influenced by Mutant Tau Overexpression.
Autorzy:: Jackson M; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA.
Chen S; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA.
Nguyen TT; Charles W. Gehrke Proteomics Center, University of Missouri, Columbia, MO 65211, USA.
Siedhoff HR; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA.; Harry S. Truman Memorial Veterans' Hospital Research Service, Columbia, MO 65201, USA.
Balderrama A; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA.; Harry S. Truman Memorial Veterans' Hospital Research Service, Columbia, MO 65201, USA.
Zuckerman A; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA.
Li R; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA.; Harry S. Truman Memorial Veterans' Hospital Research Service, Columbia, MO 65201, USA.
Greenlief CM; Charles W. Gehrke Proteomics Center, University of Missouri, Columbia, MO 65211, USA.
Cole G; Geriatric Research Education and Clinical Center (GRECC), West Los Angeles Healthcare System, Los Angeles, CA 90073, USA.; Departments of Neurology and Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Frautschy SA; Geriatric Research Education and Clinical Center (GRECC), West Los Angeles Healthcare System, Los Angeles, CA 90073, USA.; Departments of Neurology and Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Cui J; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA.; Harry S. Truman Memorial Veterans' Hospital Research Service, Columbia, MO 65201, USA.
Gu Z; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA.; Harry S. Truman Memorial Veterans' Hospital Research Service, Columbia, MO 65201, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 15; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 15.
Typ publikacji:: Journal Article
MeSH Terms:: Frontotemporal Dementia*/genetics
Tauopathies*/metabolism
Mice ; Humans ; Animals ; tau Proteins/genetics ; tau Proteins/metabolism ; Phosphopeptides ; Mice, Transgenic ; Cognition ; Disease Models, Animal

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Skocz do pozycji: 4.

Tytuł:: Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model.
Autorzy:: Zadrozny M; Mossakowski Medical Research Institute, 02-106 Warsaw, Poland.
Drapich P; Mossakowski Medical Research Institute, 02-106 Warsaw, Poland.
Gasiorowska-Bien A; Mossakowski Medical Research Institute, 02-106 Warsaw, Poland.
Niewiadomski W; Mossakowski Medical Research Institute, 02-106 Warsaw, Poland.
Harrington CR; School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK.; TauRx Therapeutics Ltd., Aberdeen AB24 3FX, UK.
Wischik CM; School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK.; TauRx Therapeutics Ltd., Aberdeen AB24 3FX, UK.
Riedel G; School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Niewiadomska G; Mossakowski Medical Research Institute, 02-106 Warsaw, Poland.; Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland.; Pokaż więcej
Źródło:: Cells [Cells] 2024 Apr 06; Vol. 13 (7). Date of Electronic Publication: 2024 Apr 06.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease*/metabolism
Tauopathies*/drug therapy
Humans ; Mice ; Animals ; Infant ; Rivastigmine/pharmacology ; tau Proteins/metabolism ; Cholinesterase Inhibitors/pharmacology ; Acetylcholinesterase/metabolism ; Neuroprotection ; Cholinergic Neurons/metabolism ; Cholinergic Agents ; Mice, Transgenic

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Skocz do pozycji: 5.

Tytuł:: Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models.
Autorzy:: Basheer N; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10, Bratislava, Slovakia.
Buee L; Inserm, CHU Lille, CNRS, LilNCog - Lille Neuroscience & Cognition, University of Lille, 59000, Lille, France. .
Brion JP; Faculty of Medicine, Laboratory of Histology, Alzheimer and Other Tauopathies Research Group (CP 620), ULB Neuroscience Institute (UNI), Université Libre de Bruxelles, 808, Route de Lennik, 1070, Brussels, Belgium.
Smolek T; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10, Bratislava, Slovakia.
Muhammadi MK; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10, Bratislava, Slovakia.
Hritz J; CEITEC Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.; Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 62500, Brno, Czech Republic.
Hromadka T; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10, Bratislava, Slovakia.
Dewachter I; Biomedical Research Institute, BIOMED, Hasselt University, 3500, Hasselt, Belgium.
Wegmann S; German Center for Neurodegenerative Diseases, Charitéplatz 1, 10117, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Landrieu I; CNRS EMR9002 - BSI - Integrative Structural Biology, 59000, Lille, France.; Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, University of Lille, 59000, Lille, France.
Novak P; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10, Bratislava, Slovakia.
Mudher A; School of Biological Sciences, Faculty of Environment and Life Sciences, University of Southampton, Highfield Campus, Southampton, SO17 1BJ, UK.
Zilka N; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10, Bratislava, Slovakia. .; AXON Neuroscience R&D Services SE, Dubravska Cesta 9, 845 10, Bratislava, Slovakia. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Apr 04; Vol. 12 (1), pp. 52. Date of Electronic Publication: 2024 Apr 04.
Typ publikacji:: Systematic Review; Journal Article; Review
MeSH Terms:: Alzheimer Disease*/pathology
Tauopathies*/pathology
Animals ; Neurofibrillary Tangles/pathology ; Disease Models, Animal ; tau Proteins/metabolism ; Brain/pathology

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Skocz do pozycji: 6.

Tytuł:: Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration.
Autorzy:: Li W; Health Sciences Institute, Key Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, China Medical University, Shenyang, 110122, China.
Li JY; Health Sciences Institute, Key Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, China Medical University, Shenyang, 110122, China. .; Neural Plasticity and Repair Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC A10, 22184, Lund, Sweden. .; Pokaż więcej
Źródło:: Translational neurodegeneration [Transl Neurodegener] 2024 Mar 26; Vol. 13 (1), pp. 16. Date of Electronic Publication: 2024 Mar 26.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Synucleinopathies*/genetics
Neurodegenerative Diseases*/genetics
Neurodegenerative Diseases*/therapy
Neurodegenerative Diseases*/metabolism
Tauopathies*/genetics
Tauopathies*/complications
Tauopathies*/metabolism
Alzheimer Disease*/genetics
Humans ; tau Proteins/metabolism

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Skocz do pozycji: 7.

Tytuł:: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer's disease: implications for biomarker development and therapeutic targeting.
Autorzy:: Rizzi L; Memory and Aging Center, Department of Neurology, Sandler Neurosciences Center, University of California San Francisco, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA.; Department of Neurology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Grinberg LT; Memory and Aging Center, Department of Neurology, Sandler Neurosciences Center, University of California San Francisco, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA. .; Department of Pathology, LIM-22, University of São Paulo Medical School, São Paulo, SP, Brazil. .; Department of Pathology, University of California San Francisco, San Francisco, CA, USA. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 28; Vol. 12 (1), pp. 36. Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Alzheimer Disease*/pathology
Tauopathies*/diagnosis
Tauopathies*/pathology
Humans ; tau Proteins/cerebrospinal fluid ; Caspases ; Biomarkers/cerebrospinal fluid

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Skocz do pozycji: 8.

Tytuł:: The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer's Disease Pathology.
Autorzy:: Wennström M; Cognitive Disorder Research Unit, Department of Clinical Sciences Malmö, Lund University, 21428 Malmö, Sweden.
Schultz N; Cognitive Disorder Research Unit, Department of Clinical Sciences Malmö, Lund University, 21428 Malmö, Sweden.; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, 21146 Malmö, Sweden.
Gallardo PM; Cognitive Disorder Research Unit, Department of Clinical Sciences Malmö, Lund University, 21428 Malmö, Sweden.
The Netherlands Brain Bank; Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.
Serrano GE; Banner Sun Health Research Institute, Sun City, AZ 85351, USA.
Beach TG; Banner Sun Health Research Institute, Sun City, AZ 85351, USA.
Bose S; Eli Lilly and Company, Arlington Square West, Bracknell RG12 1PU, UK.
Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, 21146 Malmö, Sweden.; Memory Clinic, Skåne University Hospital, 20205 Malmö, Sweden.; Pokaż więcej
Źródło:: Cells [Cells] 2024 Feb 11; Vol. 13 (4). Date of Electronic Publication: 2024 Feb 11.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease*/pathology
Tauopathies*/pathology
Humans ; Amyloid beta-Peptides ; tau Proteins/metabolism ; Brain/metabolism

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Skocz do pozycji: 9.

Tytuł:: Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease.
Autorzy:: Raulin AC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Doss SV; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Heckman MG; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Craver EC; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Li Z; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Ikezu TC; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Sekiya H; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Liu CC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; Biogen, Cambridge, MA, 02142, USA.
Martens YA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; SciNeuro Pharmaceuticals, Rockville, MD, 20850, USA.
Rosenberg CL; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Kuchenbecker LA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
DeTure M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Reichard RR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Nguyen AT; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Constantopoulos E; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Larsen RA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Kounaves EK; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Bu G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Kanekiyo T; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 09; Vol. 12 (1), pp. 25. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease*/genetics
Alzheimer Disease*/pathology
Apolipoproteins E*/genetics
Tauopathies*/pathology
Humans ; Amyloid ; Amyloid beta-Peptides ; Apolipoprotein E4/genetics ; tau Proteins

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Skocz do pozycji: 10.

Tytuł:: Spatiotemporal characteristics of neurophysiological changes in patients with four-repeat tauopathies.
Autorzy:: Samudra N; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.
Lerner H; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.
Yack L; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.; Department of Psychiatry, San Francisco Veterans Affairs, University of California San Francisco, San Francisco, California, 94158, USA.
Walsh CM; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.
Kirsch HE; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, 94143, USA.; Epilepsy Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA.
Kudo K; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, 94143, USA.; Medical Imaging Business Center, Ricoh Company, Kanazawa, Japan.
Yballa C; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.
La Joie R; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.
Gorno-Tempini ML; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.
Spina S; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.
Seeley WW; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.
Neylan TC; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.; Department of Psychiatry, San Francisco Veterans Affairs, University of California San Francisco, San Francisco, California, 94158, USA.
Miller BL; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.
Rabinovici GD; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, 94143, USA.
Boxer A; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.
Grinberg LT; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.; Department of Pathology, University of California, San Francisco, California, 94158, USA.; Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Rankin KP; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.
Nagarajan SS; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, 94143, USA.
Ranasinghe KG; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.; Pokaż więcej
Źródło:: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2024 Feb; Vol. 11 (2), pp. 525-535. Date of Electronic Publication: 2024 Jan 16.
Typ publikacji:: Case Reports; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Tauopathies*
Alzheimer Disease*/pathology
Supranuclear Palsy, Progressive*/diagnosis
Humans ; tau Proteins/metabolism ; Brain/pathology

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Skocz do pozycji: 11.

Tytuł:: Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice.
Autorzy:: Davidowitz EJ; Oligomerix, Inc., White Plains, NY, United States of America.; Oligomerix, Inc., Bronx, NY, United States of America.
Lopez P; Oligomerix, Inc., Bronx, NY, United States of America.
Jimenez H; The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States of America.
Adrien L; The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States of America.
Davies P; The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States of America.
Moe JG; Oligomerix, Inc., White Plains, NY, United States of America.; Oligomerix, Inc., Bronx, NY, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Aug 09; Vol. 18 (8), pp. e0286523. Date of Electronic Publication: 2023 Aug 09 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Neurodegenerative Diseases*
tau Proteins*/antagonists & inhibitors
tau Proteins*/metabolism
Tauopathies*/drug therapy
Tauopathies*/prevention & control
Tauopathies*/genetics
Animals ; Humans ; Mice ; Disease Models, Animal ; Mice, Transgenic ; Rhombencephalon/metabolism

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Skocz do pozycji: 12.

Tytuł:: Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau.
Autorzy:: Schweighauser M; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Murzin AG; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Macdonald J; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Lavenir I; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Crowther RA; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Scheres SHW; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. .
Goedert M; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Oct 05; Vol. 11 (1), pp. 160. Date of Electronic Publication: 2023 Oct 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: tau Proteins*/metabolism
Tauopathies*/metabolism
Humans ; Mice ; Animals ; Cryoelectron Microscopy ; Mice, Transgenic ; Brain/metabolism ; Cytoskeleton/metabolism ; Disease Models, Animal

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Skocz do pozycji: 13.

Tytuł:: A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau.
Autorzy:: Gao Y; Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. .
Wang Y; Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Lei H; Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Xu Z; Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Li S; Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Yu H; Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Xie J; Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zhang Z; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430030, China.
Liu G; Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zhang Y; Key Laboratory of Ministry of Education for Neurological Disorders, Department of Endocrine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077, China. .
Zheng J; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China. .; Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, 100083, China. .
Wang JZ; Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. .; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226000, China. .; Pokaż więcej
Źródło:: Translational neurodegeneration [Transl Neurodegener] 2023 Nov 10; Vol. 12 (1), pp. 51. Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease*/metabolism
Tauopathies*/genetics
Tauopathies*/metabolism
Tauopathies*/pathology
Animals ; Humans ; Mice ; Hippocampus/metabolism ; Mice, Transgenic ; tau Proteins/genetics ; tau Proteins/metabolism

Czasopismo naukowe

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Skocz do pozycji: 14.

Tytuł:: Tau Protein Alterations Induced by Hypobaric Hypoxia Exposure.
Autorzy:: Pena E; High Altitude Medicine Research Center (CEIMA), Arturo Prat University, Iquique 1110939, Chile.
San Martin-Salamanca R; High Altitude Medicine Research Center (CEIMA), Arturo Prat University, Iquique 1110939, Chile.
El Alam S; High Altitude Medicine Research Center (CEIMA), Arturo Prat University, Iquique 1110939, Chile.
Flores K; High Altitude Medicine Research Center (CEIMA), Arturo Prat University, Iquique 1110939, Chile.
Arriaza K; High Altitude Medicine Research Center (CEIMA), Arturo Prat University, Iquique 1110939, Chile.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 10; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Alzheimer Disease*/etiology
Tauopathies*/etiology
Humans ; Glycogen Synthase Kinase 3 beta ; Hypoxia ; tau Proteins

Czasopismo naukowe

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Skocz do pozycji: 15.

Tytuł:: Modulation of Tau Pathology in Alzheimer's Disease by Dietary Bioactive Compounds.
Autorzy:: Shi H; Department of Bioengineering, Harbin Institute of Technology, Weihai 264209, China.; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
Zhao Y; Department of Bioengineering, Harbin Institute of Technology, Weihai 264209, China.; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 09; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 09.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Tauopathies*/drug therapy
Biological Products*/therapeutic use
Humans ; Alzheimer Disease/drug therapy ; Diet ; Neurofibrillary Tangles ; tau Proteins

Czasopismo naukowe

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Skocz do pozycji: 16.

Tytuł:: Lamivudine (3TC), a Nucleoside Reverse Transcriptase Inhibitor, Prevents the Neuropathological Alterations Present in Mutant Tau Transgenic Mice.
Autorzy:: Vallés-Saiz L; Centro de Biología Molecular 'Severo Ochoa', CSIC/UAM, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Ávila J; Centro de Biología Molecular 'Severo Ochoa', CSIC/UAM, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Hernández F; Centro de Biología Molecular 'Severo Ochoa', CSIC/UAM, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jul 06; Vol. 24 (13). Date of Electronic Publication: 2023 Jul 06.
Typ publikacji:: Journal Article
MeSH Terms:: tau Proteins*/genetics
Tauopathies*/drug therapy
Tauopathies*/genetics
Tauopathies*/pathology
Mice ; Humans ; Animals ; Mice, Transgenic ; Reverse Transcriptase Inhibitors/pharmacology ; Lamivudine/pharmacology ; HeLa Cells ; Disease Models, Animal

Czasopismo naukowe

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Skocz do pozycji: 17.

Tytuł:: Nuclear face of Tau: an inside player in neurodegeneration.
Autorzy:: Younas N; University Medical Center Göttingen, National Reference Center for Surveillance of TSE, Department of Neurology, Robert-Koch strasse 40, 37075, Göttingen, Germany. .; German Center for Neurodegenerative Diseases (DZNE), Göttingen, 37075, Germany. .
Saleem T; University Medical Center Göttingen, National Reference Center for Surveillance of TSE, Department of Neurology, Robert-Koch strasse 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Göttingen, 37075, Germany.
Younas A; University Medical Center Göttingen, National Reference Center for Surveillance of TSE, Department of Neurology, Robert-Koch strasse 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Göttingen, 37075, Germany.
Zerr I; University Medical Center Göttingen, National Reference Center for Surveillance of TSE, Department of Neurology, Robert-Koch strasse 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Göttingen, 37075, Germany.; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Dec 12; Vol. 11 (1), pp. 196. Date of Electronic Publication: 2023 Dec 12.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Alzheimer Disease*/metabolism
Tauopathies*/metabolism
Animals ; Humans ; tau Proteins/metabolism ; Microtubules/metabolism ; Tubulin/metabolism

Czasopismo naukowe

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Skocz do pozycji: 18.

Tytuł:: Simple model systems reveal conserved mechanisms of Alzheimer's disease and related tauopathies.
Autorzy:: Jiang Y; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.
MacNeil LT; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada. .; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada. .; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4K1, Canada. .; Pokaż więcej
Źródło:: Molecular neurodegeneration [Mol Neurodegener] 2023 Nov 10; Vol. 18 (1), pp. 82. Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Tauopathies*/genetics
Tauopathies*/metabolism
Animals ; tau Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Disease Models, Animal ; Caenorhabditis elegans/metabolism ; Drosophila/metabolism

Czasopismo naukowe

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Skocz do pozycji: 19.

Tytuł:: Accurate digital quantification of tau pathology in progressive supranuclear palsy.
Autorzy:: Pansuwan T; Department of Clinical Neurosciences, Cambridge University Centre for Parkinson-Plus, University of Cambridge, Herchel Smith Building, Robinson Way, Cambridge, CB2 0SZ, UK. .
Quaegebeur A; Department of Clinical Neurosciences, Cambridge University Centre for Parkinson-Plus, University of Cambridge, Herchel Smith Building, Robinson Way, Cambridge, CB2 0SZ, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Kaalund SS; Centre for Neuroscience and Stereology, Bispebjerg University Hospital, Copenhagen, Denmark.
Hidari E; Department of Clinical Neurosciences, Cambridge University Centre for Parkinson-Plus, University of Cambridge, Herchel Smith Building, Robinson Way, Cambridge, CB2 0SZ, UK.
Briggs M; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Rowe JB; Department of Clinical Neurosciences, Cambridge University Centre for Parkinson-Plus, University of Cambridge, Herchel Smith Building, Robinson Way, Cambridge, CB2 0SZ, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Rittman T; Department of Clinical Neurosciences, Cambridge University Centre for Parkinson-Plus, University of Cambridge, Herchel Smith Building, Robinson Way, Cambridge, CB2 0SZ, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Nov 09; Vol. 11 (1), pp. 178. Date of Electronic Publication: 2023 Nov 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Supranuclear Palsy, Progressive*/pathology
Tauopathies*/pathology
Humans ; tau Proteins/metabolism ; Bayes Theorem ; Reproducibility of Results ; Brain/pathology

Czasopismo naukowe

na półce

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Skocz do pozycji: 20.

Tytuł:: Effective immunotherapy occurs in neurons.
Autorzy:: Nisbet RM; Florey Institute of Neuroscience and Mental Health The University of Melbourne, Parkville, Melbourne, Australia.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Mar 31; Vol. 379 (6639), pp. 1300-1301. Date of Electronic Publication: 2023 Mar 30.
Typ publikacji:: Journal Article
MeSH Terms:: Brain*/immunology
Brain*/pathology
Immunotherapy*
Neurons*/immunology
Neurons*/pathology
Tauopathies*/therapy
tau Proteins*/antagonists & inhibitors
tau Proteins*/immunology
Antibodies, Monoclonal*/therapeutic use
Humans ; Animals ; Mice

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