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Tytuł :
GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers.
Autorzy :
Li Y; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA.
Gao J; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA.
Kamran M; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA.
Harmacek L; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, 80206, USA.
Danhorn T; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, 80206, USA.
Leach SM; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA.; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, 80206, USA.
O'Connor BP; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, 80206, USA.
Hagman JR; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA.; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Huang H; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA. .; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 21; Vol. 12 (1), pp. 494. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antigens/*metabolism
Chromatin Assembly and Disassembly/*genetics
Enhancer Elements, Genetic/*genetics
GATA2 Transcription Factor/*genetics
Mast Cells/*metabolism
Animals ; Antigens/immunology ; Cell Lineage/genetics ; Cells, Cultured ; Chromatin/genetics ; Chromatin/metabolism ; Female ; GATA2 Transcription Factor/metabolism ; Gene Expression Profiling/methods ; Male ; Mast Cells/immunology ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Microphthalmia-Associated Transcription Factor/genetics ; Microphthalmia-Associated Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load.
Autorzy :
Kasetti RB; Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, TX, 76107, Fort Worth, USA.
Patel PD; Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, TX, 76107, Fort Worth, USA.
Maddineni P; Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, TX, 76107, Fort Worth, USA.
Patil S; Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, TX, 76107, Fort Worth, USA.
Kiehlbauch C; Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, TX, 76107, Fort Worth, USA.
Millar JC; Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, TX, 76107, Fort Worth, USA.
Searby CC; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Raghunathan V; Department of Basic Sciences and the Ocular Surface Institute, College of Optometry, University of Houston, Houston, TX, USA.; Department of Biomedical Engineering, Cullen College of Engineering, University of Houston, Houston, TX, USA.
Sheffield VC; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Zode GS; Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, TX, 76107, Fort Worth, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 05; Vol. 11 (1), pp. 5594. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoplasmic Reticulum Stress*/drug effects
Endoplasmic Reticulum Stress*/genetics
Protein Biosynthesis*/drug effects
Activating Transcription Factor 4/*metabolism
Glaucoma, Open-Angle/*metabolism
Activating Transcription Factor 4/antagonists & inhibitors ; Activating Transcription Factor 4/genetics ; Animals ; Aqueous Humor/metabolism ; Cell Death ; Cells, Cultured ; Glaucoma, Open-Angle/drug therapy ; Glaucoma, Open-Angle/pathology ; Humans ; Mice ; Ocular Hypertension/drug therapy ; Ocular Hypertension/metabolism ; Ocular Hypertension/pathology ; Optic Nerve/metabolism ; Optic Nerve/pathology ; Protein Phosphatase 1/genetics ; Protein Phosphatase 1/metabolism ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/pathology ; Signal Transduction ; Trabecular Meshwork/drug effects ; Trabecular Meshwork/metabolism ; Trabecular Meshwork/pathology ; Transcription Factor CHOP/genetics ; Transcription Factor CHOP/metabolism
Czasopismo naukowe
Tytuł :
Interleukin-23 drives expansion of Thelper 17 cells through epigenetic regulation by signal transducer and activators of transcription 3 in lupus patients.
Autorzy :
Lee S; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Nakayamada S; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Kubo S; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Yamagata K; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Yoshinari H; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Tanaka Y; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
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Źródło :
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2020 Oct 01; Vol. 59 (10), pp. 3058-3069.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-23/*pharmacology
Lupus Erythematosus, Systemic/*blood
STAT3 Transcription Factor/*blood
Th17 Cells/*drug effects
Azetidines/pharmacology ; CD4-Positive T-Lymphocytes/drug effects ; Cell Proliferation/drug effects ; Chromatin Immunoprecipitation/methods ; Epigenesis, Genetic ; Flow Cytometry ; Gene Expression ; Humans ; Interleukin-12/pharmacology ; Interleukins/pharmacology ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; Phosphorylation ; Purines/pharmacology ; Pyrazoles/pharmacology ; Real-Time Polymerase Chain Reaction/methods ; STAT3 Transcription Factor/drug effects ; STAT3 Transcription Factor/metabolism ; STAT4 Transcription Factor/metabolism ; Signal Transduction ; Sulfonamides/pharmacology ; Th17 Cells/metabolism
Czasopismo naukowe
Tytuł :
TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage.
Autorzy :
Yu C; Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404, Illkirch, France.; Centre National de la Recherche Scientifique (CNRS), UMR7104, 67404, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, 67404, Illkirch, France.; Université de Strasbourg, 67404, Illkirch, France.
Cvetesic N; Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.
Hisler V; Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404, Illkirch, France.; Centre National de la Recherche Scientifique (CNRS), UMR7104, 67404, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, 67404, Illkirch, France.; Université de Strasbourg, 67404, Illkirch, France.
Gupta K; Max Planck Bristol Centre for Minimal Biology, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Ye T; Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404, Illkirch, France.; Centre National de la Recherche Scientifique (CNRS), UMR7104, 67404, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, 67404, Illkirch, France.; Université de Strasbourg, 67404, Illkirch, France.
Gazdag E; Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404, Illkirch, France.; Centre National de la Recherche Scientifique (CNRS), UMR7104, 67404, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, 67404, Illkirch, France.; Université de Strasbourg, 67404, Illkirch, France.
Negroni L; Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404, Illkirch, France.; Centre National de la Recherche Scientifique (CNRS), UMR7104, 67404, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, 67404, Illkirch, France.; Université de Strasbourg, 67404, Illkirch, France.
Hajkova P; Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.
Berger I; Max Planck Bristol Centre for Minimal Biology, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Lenhard B; Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.
Müller F; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Vincent SD; Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404, Illkirch, France. .; Centre National de la Recherche Scientifique (CNRS), UMR7104, 67404, Illkirch, France. .; Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, 67404, Illkirch, France. .; Université de Strasbourg, 67404, Illkirch, France. .
Tora L; Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404, Illkirch, France. .; Centre National de la Recherche Scientifique (CNRS), UMR7104, 67404, Illkirch, France. .; Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, 67404, Illkirch, France. .; Université de Strasbourg, 67404, Illkirch, France. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 22; Vol. 11 (1), pp. 6439. Date of Electronic Publication: 2020 Dec 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Promoter Regions, Genetic*
Nuclear Proteins/*metabolism
Oocytes/*metabolism
Transcription Factor TFIIA/*metabolism
Transcriptome/*genetics
Animals ; Animals, Newborn ; Female ; Gene Expression Regulation ; Mice ; Mice, Inbred C57BL ; Mutation/genetics ; NIH 3T3 Cells ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; TATA Box ; Terminal Repeat Sequences/genetics ; Transcription Factor TFIID/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
Autorzy :
Vrijsen S; Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, Belgium.
Besora-Casals L; Cell and Developmental Biology, Department Biology II, Ludwig Maximilians Universität, 80539 Münich, Germany.
van Veen S; Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, Belgium.
Zielich J; Cell and Developmental Biology, Department Biology II, Ludwig Maximilians Universität, 80539 Münich, Germany.
Van den Haute C; Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium.; Leuven Viral Vector Core, KU Leuven, 3000 Leuven, Belgium.
Hamouda NN; Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, Belgium.
Fischer C; Cell and Developmental Biology, Department Biology II, Ludwig Maximilians Universität, 80539 Münich, Germany.; Center for Integrated Protein Science, Ludwig Maximilians Universtät, 80539 Münich, Germany.
Ghesquière B; Metabolomics Expertise Center, Vlaams Instituut voor Biotechnologie (VIB)-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.
Tournev I; Department of Neurology, Medical University-Sofia, 1431 Sofia, Bulgaria.
Agostinis P; Laboratory of Cell Death Research and Therapy, VIB-KU Leuven Center for Cancer Biology, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
Baekelandt V; Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium.
Eggermont J; Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, Belgium.
Lambie E; Cell and Developmental Biology, Department Biology II, Ludwig Maximilians Universität, 80539 Münich, Germany.; Department of Cell and Developmental Biology, University College London, WC1E 6BT London, United Kingdom.
Martin S; Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, Belgium.
Vangheluwe P; Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, Belgium; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 08; Vol. 117 (49), pp. 31198-31207. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Activating Transcription Factor 4/*genetics
Adenosine Triphosphatases/*genetics
Caenorhabditis elegans Proteins/*genetics
Mitochondria/*genetics
Proton-Translocating ATPases/*genetics
Transcription Factors/*genetics
Animals ; Caenorhabditis elegans ; Eflornithine/pharmacology ; Fibroblasts/drug effects ; Lysosomes/genetics ; Lysosomes/metabolism ; Mitochondria/drug effects ; Mitochondria/pathology ; Mutation/genetics ; Oxidative Stress/drug effects ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Polyamines/metabolism ; Rotenone/pharmacology ; Spermine/metabolism ; Transcription Factor CHOP/genetics
Czasopismo naukowe
Tytuł :
The Measles Virus V Protein Binding Site to STAT2 Overlaps That of IRF9.
Autorzy :
Nagano Y; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Sugiyama A; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Kimoto M; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Wakahara T; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Noguchi Y; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Jiang X; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Saijo S; Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Tsukuba, Japan.
Shimizu N; Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Tsukuba, Japan.
Yabuno N; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Yao M; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Gooley PR; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia.; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.
Moseley GW; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Victoria, Australia.
Tadokoro T; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Maenaka K; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.; Global Station for Biosurfaces and Drug Discovery, Center for Life Innovation, Hokkaido University.
Ose T; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan .; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.; PRESTO, Japan Science and Technology Agency, Tokyo, Japan.
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Źródło :
Journal of virology [J Virol] 2020 Aug 17; Vol. 94 (17). Date of Electronic Publication: 2020 Aug 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interferon-Stimulated Gene Factor 3, gamma Subunit/*chemistry
Measles virus/*metabolism
Phosphoproteins/*chemistry
STAT2 Transcription Factor/*chemistry
Viral Proteins/*chemistry
Binding Sites ; Gene Expression ; Humans ; Immune Evasion ; Immunity, Innate ; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics ; Interferon-Stimulated Gene Factor 3, gamma Subunit/metabolism ; Janus Kinases/metabolism ; Measles virus/genetics ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Protein Binding ; Protein Domains ; Protein Interaction Domains and Motifs ; STAT1 Transcription Factor/chemistry ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/genetics ; STAT2 Transcription Factor/metabolism ; Signal Transduction ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Zinc Fingers
Czasopismo naukowe
Tytuł :
An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate.
Autorzy :
Zagozewski J; Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
Shahriary GM; Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
Morrison LC; Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
Saulnier O; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Stromecki M; Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
Fresnoza A; Central Animal Care Services, University of Manitoba, Winnipeg, MB, Canada.
Palidwor G; Ottawa Bioinformatics Core Facility, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Porter CJ; Ottawa Bioinformatics Core Facility, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Forget A; Institut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.; Université Paris Sud, Orsay France, Université Paris-Saclay, CNRS UMR 3347, INSERM, U1021, Orsay, France.
Ayrault O; Institut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.; Université Paris Sud, Orsay France, Université Paris-Saclay, CNRS UMR 3347, INSERM, U1021, Orsay, France.
Hawkins C; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Chan JA; Department of Pathology & Laboratory Medicine, University of Calgary, Calgary, AB, Canada.
Vladoiu MC; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Sundaresan L; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Arsenio J; Departments of Internal Medicine and Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.; Manitoba Centre for Proteomics and Systems Biology, Winnipeg, MB, Canada.
Taylor MD; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.
Ramaswamy V; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Haematology/Oncology, University of Toronto and The Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Werbowetski-Ogilvie TE; Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 20; Vol. 11 (1), pp. 3627. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebellar Neoplasms*/genetics
Cerebellar Neoplasms*/metabolism
Medulloblastoma*/genetics
Medulloblastoma*/metabolism
Carcinogenesis/*genetics
Otx Transcription Factors/*metabolism
PAX3 Transcription Factor/*genetics
Animals ; Carcinogenesis/metabolism ; Cell Differentiation/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplastic Stem Cells/metabolism ; Oncogenes ; PAX3 Transcription Factor/metabolism ; PAX6 Transcription Factor/genetics ; PAX6 Transcription Factor/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
STAT3 and its targeting inhibitors in osteosarcoma.
Autorzy :
Liu Y; Department of Spine and Osteopathic Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.; Division of Regenerative Biology, School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.; Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Liao S; Division of Regenerative Biology, School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.; Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, Guangxi, China.; Department of Trauma Orthopedic and Hand Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Bennett S; Division of Regenerative Biology, School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
Tang H; Department of Orthopedic, Guangxi hospital for nationalities, Nanning, Guangxi, China.
Song D; Division of Regenerative Biology, School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.; Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Wood D; Division of Regenerative Biology, School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
Zhan X; Department of Spine and Osteopathic Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.; Division of Regenerative Biology, School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.; Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Xu J; Division of Regenerative Biology, School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Feb; Vol. 54 (2), pp. e12974. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Bone Neoplasms/*pathology
Osteosarcoma/*pathology
STAT3 Transcription Factor/*metabolism
Bone Neoplasms/drug therapy ; Bone Neoplasms/metabolism ; Cytokines/genetics ; Cytokines/metabolism ; Drug Resistance, Neoplasm ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/therapeutic use ; Humans ; Neoplasm Metastasis ; Osteosarcoma/drug therapy ; Osteosarcoma/metabolism ; Prognosis ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/chemistry ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Familial oligodontia and regional odontodysplasia associated with a PAX9 initiation codon mutation.
Autorzy :
Koskinen S; Department of Oral and Maxillofacial Diseases, Oulu University Hospital, POB 21, 90029, Oulu, Finland.
Keski-Filppula R; PEDEGO Research Unit, Clinical Genetics, Medical Research Center Oulu, University of Oulu, Oulu, Finland.; Department of Clinical Genetics, Oulu University Hospital, Oulu, Finland.
Alapulli H; Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.
Nieminen P; Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.
Anttonen V; Institute of Dentistry, Department of Cariology, Endodontology and Pedodontics, University of Oulu, POB 5281, 90014, Oulu, Finland. .; Medical Research Center, Oulu University Hospital and University of Oulu, POB 21, 90029, Oulu, Finland. .
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Źródło :
Clinical oral investigations [Clin Oral Investig] 2019 Nov; Vol. 23 (11), pp. 4107-4111. Date of Electronic Publication: 2019 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Anodontia*/genetics
Odontodysplasia*/genetics
PAX9 Transcription Factor*/genetics
Codon, Initiator ; Humans ; MSX1 Transcription Factor ; Mutation ; Pedigree
Czasopismo naukowe
Tytuł :
The stem-like Stat3-responsive cells of zebrafish intestine are Wnt/β-catenin dependent.
Autorzy :
Peron M; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58b, 35121 Padova, Italy.
Dinarello A; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58b, 35121 Padova, Italy.
Meneghetti G; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58b, 35121 Padova, Italy.
Martorano L; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58b, 35121 Padova, Italy.
Facchinello N; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58b, 35121 Padova, Italy.
Vettori A; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58b, 35121 Padova, Italy.
Licciardello G; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58b, 35121 Padova, Italy.
Tiso N; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58b, 35121 Padova, Italy.
Argenton F; Dipartimento di Biologia, Università degli Studi di Padova, Via Ugo Bassi 58b, 35121 Padova, Italy .
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Źródło :
Development (Cambridge, England) [Development] 2020 Jun 19; Vol. 147 (12). Date of Electronic Publication: 2020 Jun 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Wnt Signaling Pathway*/drug effects
Intestinal Mucosa/*metabolism
STAT3 Transcription Factor/*metabolism
Zebrafish/*metabolism
Zebrafish Proteins/*metabolism
Animals ; Animals, Genetically Modified/growth & development ; Animals, Genetically Modified/metabolism ; Intestines/growth & development ; Intestines/physiology ; Janus Kinase 1 ; Larva/growth & development ; Larva/metabolism ; Protein Kinase Inhibitors/pharmacology ; SOX9 Transcription Factor/metabolism ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/deficiency ; STAT3 Transcription Factor/genetics ; Transcription Factor 7-Like 2 Protein/deficiency ; Transcription Factor 7-Like 2 Protein/genetics ; Transcription Factor 7-Like 2 Protein/metabolism ; Transcription, Genetic/drug effects ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Wnt Proteins/metabolism ; Zebrafish/growth & development ; Zebrafish Proteins/antagonists & inhibitors ; Zebrafish Proteins/deficiency ; Zebrafish Proteins/genetics ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Microcystin-leucine arginine exposure contributes to apoptosis and follicular atresia in mice ovaries by endoplasmic reticulum stress-upregulated Ddit3.
Autorzy :
Liu H; College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
Tian Z; College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
Guo Y; School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Liu X; School of Basic Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China.
Ma Y; College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
Du X; College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
Wang R; College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
Zhang S; College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
Shi L; College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
Guo H; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, Henan, China. Electronic address: .
Zhang H; College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Feb 20; Vol. 756, pp. 144070. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article
MeSH Terms :
Marine Toxins*
Microcystins*/toxicity
Transcription Factor CHOP*/drug effects
Animals ; Apoptosis ; Arginine ; Endoplasmic Reticulum Stress ; Female ; Follicular Atresia ; Leucine ; Male ; Mice ; Ovary
Czasopismo naukowe
Tytuł :
Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.
Autorzy :
Yang T; Department of Pharmacy, Chinese PLA General Hospital, Beijing 100039, PR China.
Wang R; Integrative Medical Center, Chinese PLA General Hospital, Beijing 100039, PR China.
Liu H; Department of Policlinic, Chinese PLA General Hospital, Beijing 100039, PR China.
Wang L; Integrative Medical Center, Chinese PLA General Hospital, Beijing 100039, PR China; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
Li J; Integrative Medical Center, Chinese PLA General Hospital, Beijing 100039, PR China; Colorectal and Anal Surgery, Chengdu Anorectal Hospital, No 152 Daqiang East Street, Taisheng South Road, Chengdu 610075, PR China.
Wu S; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
Chen X; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
Yang X; Colorectal and Anal Surgery, Chengdu Anorectal Hospital, No 152 Daqiang East Street, Taisheng South Road, Chengdu 610075, PR China. Electronic address: .
Zhao Y; Department of Pharmacy, Chinese PLA General Hospital, Beijing 100039, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118903. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article
MeSH Terms :
Berberine/*pharmacology
Gastritis, Atrophic/*drug therapy
Helicobacter Infections/*complications
Helicobacter pylori/*isolation & purification
Interleukin-4/*metabolism
Macrophage Activation/*immunology
STAT6 Transcription Factor/*metabolism
Animals ; Gastritis, Atrophic/etiology ; Gastritis, Atrophic/pathology ; Gene Expression Regulation ; Helicobacter Infections/microbiology ; Humans ; Interleukin-4/genetics ; Macrophage Activation/drug effects ; Male ; Mice ; Rats ; STAT6 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
DDIT3 Immunohistochemistry Is a Useful Tool for the Diagnosis of Myxoid Liposarcoma.
Autorzy :
Scapa JV; Department of Pathology, Stanford University School of Medicine, Stanford, CA.
Cloutier JM
Raghavan SS
Peters-Schulze G
Varma S
Charville GW
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Źródło :
The American journal of surgical pathology [Am J Surg Pathol] 2021 Feb 01; Vol. 45 (2), pp. 230-239.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Biomarkers, Tumor/*analysis
Liposarcoma, Myxoid/*diagnosis
Soft Tissue Neoplasms/*diagnosis
Transcription Factor CHOP/*analysis
Humans ; Immunohistochemistry ; Transcription Factor CHOP/biosynthesis
Czasopismo naukowe
Tytuł :
Cilostazol mitigates mesenteric ischemia/reperfusion-induced lung lesion: Contribution of PPAR-γ, NF-κB, and STAT3 crosstalk.
Autorzy :
Gendy AM; Pharmacology and Toxicology Department, Faculty of Pharmacy, October 6 University, Giza, Egypt. Electronic address: .
Amin MM; Pharmacology Department, Medical Division, National Research Centre, Dokki, Egypt.
Al-Mokaddem AK; Pathology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Abd Ellah MF; Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University (Boys), Cairo, Egypt.
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118882. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Cilostazol/*pharmacology
Lung Diseases/*prevention & control
Mesenteric Ischemia/*complications
NF-kappa B/*metabolism
PPAR gamma/*metabolism
Reperfusion Injury/*complications
STAT3 Transcription Factor/*metabolism
Animals ; Bronchodilator Agents/pharmacology ; Gene Expression Regulation ; Lung Diseases/etiology ; Lung Diseases/metabolism ; Lung Diseases/pathology ; Male ; NF-kappa B/genetics ; Oxidative Stress ; PPAR gamma/genetics ; Rats ; Rats, Wistar ; STAT3 Transcription Factor/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice.
Autorzy :
Sankoda N; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.; Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.; Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Tanabe W; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.; Department of Gastroenterology, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Tanaka A; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.
Shibata H; Department of Otolaryngology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.
Woltjen K; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.; Hakubi Center for Advanced Research, Kyoto University, Kyoto, 606-8501, Japan.
Chiba T; Department of Gastroenterology, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Haga H; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, 606-8507, Japan.
Sakai Y; Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Mandai M; Department of Gynecology and Obstetrics, Kyoto University Hospital, Kyoto, 606-8507, Japan.
Yamamoto T; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.; AMED-CREST, AMED 1-7-1 Otemachi, Chiyodaku, Tokyo, 100-0004, Japan.; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.; Medical-risk Avoidance Based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto, 606-8507, Japan.
Yamada Y; Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.; AMED-CREST, AMED 1-7-1 Otemachi, Chiyodaku, Tokyo, 100-0004, Japan.
Uemoto S; Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Kawaguchi Y; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 25; Vol. 12 (1), pp. 560. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Epithelial Cells/*metabolism
GATA4 Transcription Factor/*genetics
Intercellular Junctions/*genetics
MAP Kinase Signaling System/*genetics
SOXB1 Transcription Factors/*genetics
Animals ; Cells, Cultured ; Female ; GATA4 Transcription Factor/metabolism ; Gastric Mucosa/metabolism ; Keratin-7/genetics ; Keratin-7/metabolism ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Mice, Knockout ; Mice, Transgenic ; SOXB1 Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.
Autorzy :
Hao P; Department of Biology and Bioinformatics Program, Boston University, Boston, Massachusetts, USA.
Waxman DJ; Department of Biology and Bioinformatics Program, Boston University, Boston, Massachusetts, USA .
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2021 Jan 25; Vol. 41 (2). Date of Electronic Publication: 2021 Jan 25 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Methylation*
Epigenesis, Genetic*
Histones/*genetics
Liver/*metabolism
STAT5 Transcription Factor/*genetics
Animals ; Base Sequence ; Chromatin/chemistry ; Chromatin/metabolism ; CpG Islands ; Enhancer Elements, Genetic ; Female ; Gene Expression Profiling ; Histones/metabolism ; Male ; Metabolic Networks and Pathways/genetics ; Mice ; Mice, Knockout ; Promoter Regions, Genetic ; Protein Binding ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; STAT5 Transcription Factor/metabolism ; Sex Distribution
Czasopismo naukowe
Tytuł :
Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors.
Autorzy :
Brotherton-Pleiss C; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.; Medicinal Chemistry Leader, Department of Chemistry, University of Hawaii, Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 9682, United States.
Yue P; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.
Zhu Y
Nakamura K; Department of Chemistry, University of Hawaii, Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 9682, United States.
Chen W; Department of Chemistry, University of Hawaii, Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 9682, United States.
Fu W; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.; Department of Chemistry, University of Hawaii, Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 9682, United States.
Kubota C; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.
Chen J; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.
Alonso-Valenteen F; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
Mikhael S; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
Medina-Kauwe L; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
Tius MA; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.; Medicinal Chemistry Leader, Department of Chemistry, University of Hawaii, Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 9682, United States.
Lopez-Tapia F; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.; Medicinal Chemistry Leader, Department of Chemistry, University of Hawaii, Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 9682, United States.
Turkson J; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jan 14; Vol. 64 (1), pp. 695-710. Date of Electronic Publication: 2020 Dec 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Azetidines/*chemistry
STAT3 Transcription Factor/*antagonists & inhibitors
Amides/chemistry ; Apoptosis/drug effects ; Azetidines/metabolism ; Azetidines/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA/chemistry ; DNA/metabolism ; Drug Evaluation, Preclinical ; Humans ; Inhibitory Concentration 50 ; Phosphorylation/drug effects ; Protein Binding ; STAT3 Transcription Factor/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Novel MSX1 variants identified in families with nonsyndromic oligodontia.
Autorzy :
Zheng J; Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Yu M; Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Liu H; Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Cai T; National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA.
Feng H; Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Liu Y; Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, China. .
Han D; Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, China. .
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Źródło :
International journal of oral science [Int J Oral Sci] 2021 Jan 08; Vol. 13 (1), pp. 2. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anodontia*/genetics
MSX1 Transcription Factor*/genetics
Humans ; Pedigree ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Renoprotective effect of Stat1 deletion in murine aristolochic acid nephropathy.
Autorzy :
Feng W; Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Ying WZ; Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Li X; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.
Curtis LM; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.
Sanders PW; Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.; Department of Veterans Affairs Medical Center, Birmingham, Alabama.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2021 Jan 01; Vol. 320 (1), pp. F87-F96. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Aristolochic Acids*
Gene Deletion*
Extracellular Matrix/*metabolism
Kidney Tubules, Proximal/*metabolism
Renal Insufficiency, Chronic/*prevention & control
STAT1 Transcription Factor/*deficiency
Animals ; Disease Models, Animal ; Extracellular Matrix/pathology ; Fibrosis ; Hepatitis A Virus Cellular Receptor 1/metabolism ; Integrin beta Chains/metabolism ; Kidney Tubules, Proximal/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation ; Renal Insufficiency, Chronic/chemically induced ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/pathology ; STAT1 Transcription Factor/genetics ; Signal Transduction ; Smad2 Protein/metabolism ; Smad3 Protein/metabolism
Czasopismo naukowe
Tytuł :
Cytotoxicity of apigenin toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells.
Autorzy :
Adham AN; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Abdelfatah S; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Naqishbandi AM; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq. Electronic address: .
Mahmoud N; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Jan; Vol. 80, pp. 153371. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Apigenin/*pharmacology
Cyclooxygenase 2/*metabolism
Multiple Myeloma/*drug therapy
Nitric Oxide Synthase Type II/*antagonists & inhibitors
STAT1 Transcription Factor/*genetics
Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Apigenin/administration & dosage ; Apoptosis/drug effects ; Autophagy/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Computational Biology/methods ; Dose-Response Relationship, Drug ; Doxorubicin/administration & dosage ; HEK293 Cells ; Humans ; Multiple Myeloma/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Reactive Oxygen Species/metabolism ; STAT1 Transcription Factor/metabolism
Czasopismo naukowe

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