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Tytuł:
ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced Transcription through Genome-Wide Binding of Phosphorylated and Unphosphorylated Complexes to Common ISRE-Containing ISGs.
Autorzy:
Nowicka H; Human Molecular Genetics Research Unit, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Sekrecka A; Human Molecular Genetics Research Unit, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Blaszczyk K; Human Molecular Genetics Research Unit, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Kluzek K; Human Molecular Genetics Research Unit, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Chang CY; Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Wesoly J; Laboratory of High Throughput Technologies, Faculty of Biology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Lee CK; Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Bluyssen HAR; Human Molecular Genetics Research Unit, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 61-614 Poznan, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 18; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 18.
Typ publikacji:
Journal Article
MeSH Terms:
Interferon Type I*/metabolism
Interleukin-1 Receptor-Like 1 Protein*/metabolism
Interferon-Stimulated Gene Factor 3*/metabolism
STAT2 Transcription Factor*/metabolism
Antiviral Agents/pharmacology ; DNA/pharmacology ; Immunoglobulins/metabolism ; Signal Transduction ; STAT1 Transcription Factor/metabolism ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
c-FOS is an integral component of the IKZF1 transactivator complex and mediates lenalidomide resistance in multiple myeloma.
Autorzy:
Osada N; Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.
Kikuchi J; Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.
Iha H; Division of Pathophysiology, The Research Center for GLOBAL and LOCAL Infectious Diseases (RCGLID), Oita University, Oita, Japan.
Yasui H; Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.; Project Division of Innovative Diagnostics Technology Platform, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Ikeda S; Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.
Takahashi N; Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.
Furukawa Y; Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.; Center for Medical Education, Teikyo University of Science, Tokyo, Japan.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2023 Aug; Vol. 13 (8), pp. e1364.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ikaros Transcription Factor*/genetics
Ikaros Transcription Factor*/metabolism
Lenalidomide*/pharmacology
Lenalidomide*/therapeutic use
Multiple Myeloma*/drug therapy
Multiple Myeloma*/genetics
Drug Resistance, Neoplasm*
Proto-Oncogene Proteins c-fos*/genetics
Proto-Oncogene Proteins c-fos*/metabolism
Animals ; Humans ; Mice ; Bone Marrow ; Trans-Activators/therapeutic use ; Transcription Factor AP-1/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The association of E2F1 and E2F2 single nucleotide polymorphisms with laryngeal squamous cell carcinoma pathomorphological features.
Autorzy:
Jakstas T; Department of Otorhinolaryngology, Lithuanian University of Health Sciences, Kaunas, Lithuania. .
Bartnykaite A; Oncology Research Laboratory, Oncology Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Padervinskis E; Department of Otorhinolaryngology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Vegiene A; Department of Otorhinolaryngology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Juozaityte E; Oncology Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Uloza V; Department of Otorhinolaryngology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Ugenskiene R; Oncology Research Laboratory, Oncology Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.; Department of Genetics and Molecular Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.
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Źródło:
BMC cancer [BMC Cancer] 2024 Feb 15; Vol. 24 (1), pp. 214. Date of Electronic Publication: 2024 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
E2F1 Transcription Factor*/genetics
E2F2 Transcription Factor*/genetics
Laryngeal Neoplasms*/genetics
Laryngeal Neoplasms*/pathology
Squamous Cell Carcinoma of Head and Neck*/genetics
Squamous Cell Carcinoma of Head and Neck*/pathology
Humans ; Polymorphism, Single Nucleotide ; Prognosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Crucial role of TFAP2B in the nervous system for regulating NREM sleep.
Autorzy:
Nakai A; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, 305-8575, Japan.
Kashiwagi M; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, 305-8575, Japan.; Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, 113-0033, Japan.
Fujiyama T; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, 305-8575, Japan.
Iwasaki K; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, 305-8575, Japan.
Hirano A; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, 305-8575, Japan.; Institute of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Funato H; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, 305-8575, Japan.; Department of Anatomy, Toho University Graduate School of Medicine, Tokyo, 143-8540, Japan.
Yanagisawa M; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, 305-8575, Japan.; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, 305-8577, Japan.
Sakurai T; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, 305-8575, Japan.; Institute of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Hayashi Y; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, 305-8575, Japan. .; Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, 113-0033, Japan. .
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Źródło:
Molecular brain [Mol Brain] 2024 Feb 27; Vol. 17 (1), pp. 13. Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Transcription Factor AP-2*/genetics
Transcription Factor AP-2*/metabolism
Transcription Factors*
Animals ; Mice ; Nervous System/metabolism ; Sleep
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Study on the Antitumor Mechanism of Tanshinone IIA In Vivo and In Vitro through the Regulation of PERK-ATF4-HSPA5 Pathway-Mediated Ferroptosis.
Autorzy:
Guo C; School of Basic Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
Zhao W; School of Basic Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.; Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, Kunming 650500, China.
Wang W; School of Basic Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.; Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, Kunming 650500, China.
Yao Z; School of Basic Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.; Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, Kunming 650500, China.
Chen W; School of Basic Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.; Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, Kunming 650500, China.
Feng X; School of Basic Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.; Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, Kunming 650500, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Mar 30; Vol. 29 (7). Date of Electronic Publication: 2024 Mar 30.
Typ publikacji:
Journal Article
MeSH Terms:
Activating Transcription Factor 4*/genetics
Ferroptosis*
Animals ; Mice ; Endoplasmic Reticulum Chaperone BiP ; Abietanes/pharmacology ; Glutathione
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys.
Autorzy:
Aggarwal S; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Wang Z; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Rincon Fernandez Pacheco D; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Rinaldi A; Division of Nephrology, Ente Ospedaliero Cantonale, CH-6900 Lugano, Switzerland.
Rajewski A; Applied Genomics, Computation, and Translational Core, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Callemeyn J; Department of Microbiology, Immunology and Transplantation, KU Leuven, BE-3000 Leuven, Belgium.
Van Loon E; Department of Microbiology, Immunology and Transplantation, KU Leuven, BE-3000 Leuven, Belgium.
Lamarthée B; Department of Microbiology, Immunology and Transplantation, KU Leuven, BE-3000 Leuven, Belgium.
Covarrubias AE; Division of Nephrology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Hou J; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Yamashita M; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Akiyama H; Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Karumanchi SA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Division of Nephrology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Svendsen CN; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Noble PW; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Jordan SC; Division of Nephrology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Breunig JJ; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Naesens M; Department of Microbiology, Immunology and Transplantation, KU Leuven, BE-3000 Leuven, Belgium.
Cippà PE; Division of Nephrology, Ente Ospedaliero Cantonale, CH-6900 Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-6900 Lugano, Switzerland.
Kumar S; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Division of Nephrology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Feb 23; Vol. 383 (6685), pp. eadd6371. Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Acute Kidney Injury*/genetics
Acute Kidney Injury*/pathology
Kidney*/pathology
Renal Insufficiency, Chronic*/genetics
Renal Insufficiency, Chronic*/pathology
SOX9 Transcription Factor*/genetics
Animals ; Humans ; Epithelial Cells ; Fibrosis ; Regeneration ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Roles of Glutathione and AP-1 in the Enhancement of Vitamin D-Induced Differentiation by Activators of the Nrf2 Signaling Pathway in Acute Myeloid Leukemia Cells.
Autorzy:
Jramne-Saleem Y; Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
Danilenko M; Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 14; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Transcription Factor AP-1*/metabolism
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/metabolism
Abietanes*
Humans ; NF-E2-Related Factor 2/metabolism ; Antioxidants/pharmacology ; Vitamin D/therapeutic use ; Vitamins/pharmacology ; Receptors, Calcitriol/metabolism ; Cell Differentiation ; Signal Transduction ; Glutathione/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Terpenoid-Mediated Targeting of STAT3 Signaling in Cancer: An Overview of Preclinical Studies.
Autorzy:
Khan F; Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602105, India.
Pandey P; University Centre for Research and Development, Chandigarh University, Gharuan, Mohali 140413, India.
Verma M; University Centre for Research and Development, Chandigarh University, Gharuan, Mohali 140413, India.; Department of Chemistry, University Institute of Sciences, Chandigarh University, Gharuan, Mohali 140413, India.
Upadhyay TK; Department of Biotechnology, Parul Institute of Applied Sciences and Research and Development Cell, Parul University, Vadodara 391760, India.
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Źródło:
Biomolecules [Biomolecules] 2024 Feb 07; Vol. 14 (2). Date of Electronic Publication: 2024 Feb 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/drug therapy
STAT3 Transcription Factor*/metabolism
Humans ; Apoptosis ; Cell Proliferation ; Plant Extracts/pharmacology ; Signal Transduction ; Terpenes/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Autorzy:
Montoya S; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Bourcier J; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Noviski M; Nurix Therapeutics, San Francisco, CA, USA.
Lu H; Nurix Therapeutics, San Francisco, CA, USA.
Thompson MC; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chirino A; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Jahn J; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Sondhi AK; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Gajewski S; Nurix Therapeutics, San Francisco, CA, USA.
Tan YSM; Nurix Therapeutics, San Francisco, CA, USA.
Yung S; Nurix Therapeutics, San Francisco, CA, USA.
Urban A; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; K.G. Jebsen Centre for B Cell Malignancies, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Wang E; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Han C; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Mi X; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kim WJ; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sievers Q; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Auger P; Nurix Therapeutics, San Francisco, CA, USA.
Bousquet H; Nurix Therapeutics, San Francisco, CA, USA.
Brathaban N; Nurix Therapeutics, San Francisco, CA, USA.
Bravo B; Nurix Therapeutics, San Francisco, CA, USA.
Gessner M; Nurix Therapeutics, San Francisco, CA, USA.
Guiducci C; Nurix Therapeutics, San Francisco, CA, USA.
Iuliano JN; Nurix Therapeutics, San Francisco, CA, USA.
Kane T; Nurix Therapeutics, San Francisco, CA, USA.
Mukerji R; Nurix Therapeutics, San Francisco, CA, USA.
Reddy PJ; Nurix Therapeutics, San Francisco, CA, USA.
Powers J; Nurix Therapeutics, San Francisco, CA, USA.
Sanchez Garcia de Los Rios M; Nurix Therapeutics, San Francisco, CA, USA.
Ye J; Nurix Therapeutics, San Francisco, CA, USA.
Barrientos Risso C; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Tsai D; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Pardo G; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Notti RQ; Laboratory of Molecular Electron Microscopy, Rockefeller University, New York, NY, USA.
Pardo A; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Affer M; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Nawaratne V; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Totiger TM; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Pena-Velasquez C; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Rhodes JM; Division of Hematology-Oncology, Department of Medicine at Zucker School of Medicine at Hofstra/Northwell, CLL Research and Treatment Center, Lake Success, NY, USA.
Zelenetz AD; Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alencar A; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Roeker LE; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mehta S; Gene Editing and Screening Core Facility, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Institute and Cancer Center, New York, NY, USA.
Garippa R; Gene Editing and Screening Core Facility, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Institute and Cancer Center, New York, NY, USA.
Linley A; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Soni RK; Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Skånland SS; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; K.G. Jebsen Centre for B Cell Malignancies, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Brown RJ; Nurix Therapeutics, San Francisco, CA, USA.
Mato AR; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Hansen GM; Nurix Therapeutics, San Francisco, CA, USA.
Abdel-Wahab O; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Taylor J; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Feb 02; Vol. 383 (6682), pp. eadi5798. Date of Electronic Publication: 2024 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Agammaglobulinaemia Tyrosine Kinase*/genetics
Agammaglobulinaemia Tyrosine Kinase*/metabolism
Ikaros Transcription Factor*/metabolism
Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell*/genetics
Protein Kinase Inhibitors*/pharmacology
Protein Kinase Inhibitors*/therapeutic use
Proteolysis*/drug effects
Drug Resistance, Neoplasm*/drug effects
Humans ; Mutation ; Phosphorylation ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Non-canonical STAT3 function reduces REDD1 transcription.
Autorzy:
Köhler N; Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany.
Wundrack N; Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany.
Schulz S; Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany.
Bartonitz F; Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany.
Schaper F; Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany.; Center for Dynamic Systems: Systems Engineering (CDS), Otto-von-Guericke University Magdeburg, Germany.; Magdeburg Center for Systems Biology (MACS), Otto-von-Guericke University Magdeburg, Germany.
Dittrich A; Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany.; Center for Dynamic Systems: Systems Engineering (CDS), Otto-von-Guericke University Magdeburg, Germany.; Magdeburg Center for Systems Biology (MACS), Otto-von-Guericke University Magdeburg, Germany.
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Źródło:
The FEBS journal [FEBS J] 2023 Apr; Vol. 290 (7), pp. 1765-1781. Date of Electronic Publication: 2022 Dec 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*
STAT3 Transcription Factor*/genetics
STAT3 Transcription Factor*/metabolism
Gene Expression Regulation ; Transcription, Genetic ; STAT1 Transcription Factor/genetics ; RNA, Messenger/genetics ; Transcriptional Activation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery.
Autorzy:
Hu Y; Tianjian Laboratory for Advanced Biomedical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, Henan, China.; Medical Research Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China.
Dong Z; Tianjian Laboratory for Advanced Biomedical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, Henan, China. .; China-US (Henan) Hormel Cancer Institute, Zhengzhou, 450008, Henan, China. .; Cancer Chemoprevention International Collaboration Laboratory, Zhengzhou, Henan, China. .
Liu K; Tianjian Laboratory for Advanced Biomedical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, Henan, China. .; China-US (Henan) Hormel Cancer Institute, Zhengzhou, 450008, Henan, China. .; State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, Henan, China. .; Provincial Cooperative Innovation Center for Cancer Chemoprevention, Zhengzhou, Henan, China. .; Cancer Chemoprevention International Collaboration Laboratory, Zhengzhou, Henan, China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Jan 20; Vol. 43 (1), pp. 23. Date of Electronic Publication: 2024 Jan 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
STAT3 Transcription Factor*/genetics
STAT3 Transcription Factor*/metabolism
Neoplasms*/drug therapy
Neoplasms*/genetics
Neoplasms*/pathology
Humans ; Signal Transduction ; Immunosuppression Therapy ; Drug Discovery ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms.
Autorzy:
Bjorkman SH; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA.; Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility, University of Iowa Hospital and Clinics, Iowa City, IA, USA.
Marti A; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA.
Jena J; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA.
García-Peña LM; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA.
Weatherford ET; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA.
Kato K; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA.
Koneru J; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA.
Chen J; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA.
Sood A; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA.
Potthoff MJ; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA.; Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Adams CM; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA.; Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Abel ED; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA.; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Pereira RO; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, 4338 PBDB, Iowa City, IA, 52242, USA. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 18; Vol. 14 (1), pp. 1563. Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Activating Transcription Factor 4*/genetics
Activating Transcription Factor 4*/metabolism
Fibroblast Growth Factors*
Thermogenesis*/genetics
Animals ; Mice ; Adipocytes/metabolism ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, White/metabolism ; Amino Acids/metabolism ; Cold Temperature ; Mice, Inbred C57BL ; Uncoupling Protein 1/genetics ; Uncoupling Protein 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anti-inflammatory effects of reticuline on the JAK2/STAT3/SOCS3 and p38 MAPK/NF-κB signaling pathway in a mouse model of obesity-associated asthma.
Autorzy:
Lyu X; Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Liu J; Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Liu Z; Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Wu Y; Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Zhu P; Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Liu C; Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
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Źródło:
The clinical respiratory journal [Clin Respir J] 2024 Jan; Vol. 18 (1), pp. e13729.
Typ publikacji:
Journal Article
MeSH Terms:
Asthma*/drug therapy
Asthma*/metabolism
Benzylisoquinolines*/pharmacology
Benzylisoquinolines*/therapeutic use
Janus Kinase 2*/drug effects
Janus Kinase 2*/metabolism
NF-kappa B*/drug effects
NF-kappa B*/metabolism
STAT3 Transcription Factor*/drug effects
STAT3 Transcription Factor*/metabolism
Animals ; Mice ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Bronchoalveolar Lavage Fluid ; Cytokines/metabolism ; Disease Models, Animal ; Inflammation/metabolism ; Lung/pathology ; Mice, Inbred BALB C ; Obesity/complications ; Obesity/drug therapy ; p38 Mitogen-Activated Protein Kinases/metabolism ; p38 Mitogen-Activated Protein Kinases/pharmacology ; p38 Mitogen-Activated Protein Kinases/therapeutic use ; Signal Transduction ; Suppressor of Cytokine Signaling 3 Protein/drug effects ; Suppressor of Cytokine Signaling 3 Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MiR-192-5p Ameliorates Hepatic Lipid Metabolism in Non-Alcoholic Fatty Liver Disease by Targeting Yy1 .
Autorzy:
Ma L; Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.; Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Nanjing 210023, China.; Research Unit of Extracellular RNA, Chinese Academy of Medical Sciences, Nanjing 210023, China.
Song H; Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.; Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Nanjing 210023, China.; Research Unit of Extracellular RNA, Chinese Academy of Medical Sciences, Nanjing 210023, China.
Zhang CY; Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.; Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Nanjing 210023, China.; Research Unit of Extracellular RNA, Chinese Academy of Medical Sciences, Nanjing 210023, China.
Hou D; Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.; Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Nanjing 210023, China.; Research Unit of Extracellular RNA, Chinese Academy of Medical Sciences, Nanjing 210023, China.
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Źródło:
Biomolecules [Biomolecules] 2023 Dec 26; Vol. 14 (1). Date of Electronic Publication: 2023 Dec 26.
Typ publikacji:
Journal Article
MeSH Terms:
MicroRNAs*/genetics
Non-alcoholic Fatty Liver Disease*/genetics
YY1 Transcription Factor*/genetics
YY1 Transcription Factor*/metabolism
Animals ; Humans ; Mice ; Fatty Acids, Nonesterified ; Hepatocytes ; Lipid Metabolism/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cell cycle regulation of the psoriasis associated gene CCHCR1 by transcription factor E2F1.
Autorzy:
Ling YH; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Chen Y; School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Leung KN; School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Chan KM; School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Liu WK; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
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Źródło:
PloS one [PLoS One] 2023 Dec 21; Vol. 18 (12), pp. e0294661. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
E2F1 Transcription Factor*/genetics
E2F1 Transcription Factor*/metabolism
Psoriasis*/genetics
Psoriasis*/metabolism
Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Gene Expression Regulation ; Cell Cycle ; E2F Transcription Factors/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4.
Autorzy:
Ulrich C; Department of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Canim Z; Department of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Herberger E; Department of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Girndt M; Department of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Fiedler R; Department of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 16; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 16.
Typ publikacji:
Journal Article
MeSH Terms:
Caspases*
Leukocytes, Mononuclear*/metabolism
Renal Dialysis*/adverse effects
Transcription Factor RelB*/genetics
Transcription Factor RelB*/metabolism
Humans ; Cross-Sectional Studies ; Endotoxins ; Inflammation ; Interleukin-6 ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma.
Autorzy:
Wang L; Department of Obstetrics and Gynecology, Center of Genetics and Prenatal Diagnosis, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China.
Zhao QF; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, P. R. China.; Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou University, Zhengzhou, P. R. China.
Yang BB; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, P. R. China.; Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou University, Zhengzhou, P. R. China.; State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou, P. R. China.
Liang HJ; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, P. R. China.; Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou University, Zhengzhou, P. R. China.
Zhang XE; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, P. R. China.; Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou University, Zhengzhou, P. R. China.; Second People's Hospital of Henan Province, Zhengzhou, P. R. China.
Zhang XY; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, P. R. China.; Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou University, Zhengzhou, P. R. China.
Yang WJ; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, P. R. China.; Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou University, Zhengzhou, P. R. China.
Guo ZY; SanQuan College of XinXiang Medical University, Xinxiang, P. R. China.
Xu X; College of Biotechnology, Center for Self-Propelled Nanotechnologies, Suzhou Industrial Park Institute of Services Outsourcing, Suzhou, P. R. China.; Translational Cancer Research Laboratory, Suzhou Acumen Medical Technology, Suzhou, P. R. China.
Tian F; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, P. R. China.; Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou University, Zhengzhou, P. R. China.; State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou, P. R. China.
Wu QH; Department of Obstetrics and Gynecology, Center of Genetics and Prenatal Diagnosis, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China.
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Źródło:
Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2023 Dec; Vol. 62 (12), pp. 1757-1766. Date of Electronic Publication: 2023 Nov 25.
Typ publikacji:
Journal Article
MeSH Terms:
Esophageal Neoplasms*/genetics
Esophageal Neoplasms*/pathology
Esophageal Squamous Cell Carcinoma*/genetics
Esophageal Squamous Cell Carcinoma*/pathology
STAT3 Transcription Factor*/genetics
STAT3 Transcription Factor*/metabolism
Receptor, EphA7*/metabolism
Humans ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TFIIB-Related Protein BRP5/PTF2 Is Required for Both Male and Female Gametogenesis and for Grain Formation in Rice.
Autorzy:
Chen G; College of Life Sciences, China Jiliang University, 258 Xueyuan Street, Hangzhou 310018, China.
Hu H; College of Life Sciences, China Jiliang University, 258 Xueyuan Street, Hangzhou 310018, China.
Chen X; College of Life Sciences, China Jiliang University, 258 Xueyuan Street, Hangzhou 310018, China.
Chen J; College of Life Sciences, China Jiliang University, 258 Xueyuan Street, Hangzhou 310018, China.
Wang S; College of Life Sciences, China Jiliang University, 258 Xueyuan Street, Hangzhou 310018, China.
Ning H; College of Life Sciences, China Jiliang University, 258 Xueyuan Street, Hangzhou 310018, China.
Zhu C; College of Life Sciences, China Jiliang University, 258 Xueyuan Street, Hangzhou 310018, China.
Yang S; College of Life Sciences, China Jiliang University, 258 Xueyuan Street, Hangzhou 310018, China.; Institute of Crop Science and Zhejiang Key Laboratory of Crop Germplasm, Zhejiang University, Hangzhou 310058, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 18; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 18.
Typ publikacji:
Journal Article
MeSH Terms:
Oryza*/genetics
Oryza*/metabolism
Transcription Factor TFIIB*/metabolism
Plant Proteins*/metabolism
Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Gametogenesis ; Gene Expression Regulation, Plant ; Plants/metabolism ; Pollen/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ANGPTL4 accelerates ovarian serous cystadenocarcinoma carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1.
Autorzy:
Li YK; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Gao AB; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.; Clinical Research Institute, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Zeng T; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Liu D; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.
Zhang QF; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Ran XM; Department of Gynecologic Oncology, School of Medicine, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya, Central South University, Changsha, Hunan, China.
Tang ZZ; Department of Gynecologic Oncology, School of Medicine, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya, Central South University, Changsha, Hunan, China.
Li Y; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.
Liu J; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Zhang T; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Shi GQ; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Zhou WC; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Zou WD; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.
Peng J; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.
Zhang J; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. .
Li H; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. lihui_.
Zou J; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. .; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Jan 11; Vol. 22 (1), pp. 46. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Cystadenocarcinoma, Serous*
Ovarian Neoplasms*/genetics
STAT3 Transcription Factor*
Janus Kinase 2*
Animals ; Female ; Humans ; Tumor Microenvironment ; Molecular Docking Simulation ; Angiogenesis ; Zebrafish/metabolism ; Carcinogenesis ; Cell Proliferation ; Carcinoma, Ovarian Epithelial ; Cell Line, Tumor ; Angiopoietin-Like Protein 4/genetics ; Neoplasm Proteins ; Proteoglycans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition.
Autorzy:
Biswal M; Department of Biochemistry, University of California, Riverside, CA, USA.
Yao W; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.
Lu J; Department of Biochemistry, University of California, Riverside, CA, USA.
Chen J; Department of Biochemistry, University of California, Riverside, CA, USA.
Morrison J; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.
Hai R; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA. .
Song J; Department of Biochemistry, University of California, Riverside, CA, USA. .
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Źródło:
Communications biology [Commun Biol] 2024 Jan 10; Vol. 7 (1), pp. 76. Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Flavivirus*
STAT2 Transcription Factor*/metabolism
Zika Virus*
Zika Virus Infection*
Viral Nonstructural Proteins*/metabolism
Humans ; Proteolysis ; Species Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 18229

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