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Tytuł :
Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma.
Autorzy :
Sumitomo M; Fujita Cancer Center, Fujita Health University, Toyoake, Japan.; Department of Medical Research for Intractable Disease, Fujita Health University, Toyoake, Japan.; Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan.
Takahara K; Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan.
Zennami K; Fujita Cancer Center, Fujita Health University, Toyoake, Japan.; Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan.
Nagakawa T; Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan.
Maeda Y; Research Promotion and Support Headquarters, Center for Joint Research Facilities Support, Fujita Health University, Toyoake, Japan.
Shiogama K; Department of Pathology, School of Health Sciences, Fujita Health University, Toyoake, Japan.
Yamamoto Y; Department of Disease Control and Prevention, Fujita Health University, Toyoake, Japan.
Muto Y; Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan.
Nukaya T; Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan.
Takenaka M; Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan.
Fukaya K; Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan.
Ichino M; Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan.
Sasaki H; Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan.
Saito K; Department of Disease Control and Prevention, Fujita Health University, Toyoake, Japan.
Shiroki R; Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Mar; Vol. 112 (3), pp. 1038-1047. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Carcinoma, Renal Cell/*therapy
Kidney/*pathology
Kidney Neoplasms/*therapy
Tryptophan Oxygenase/*metabolism
Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Renal Cell/mortality ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Chemotherapy, Adjuvant ; Disease Progression ; Drug Resistance, Neoplasm ; Female ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Immunohistochemistry ; Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Kidney/surgery ; Kidney Neoplasms/mortality ; Kidney Neoplasms/pathology ; Kynurenine/analysis ; Kynurenine/metabolism ; Male ; Middle Aged ; Nephrectomy ; Progression-Free Survival ; Tryptophan/metabolism ; Tryptophan Oxygenase/analysis ; Tryptophan Oxygenase/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
The Effect of Chronic Mild Stress and Escitalopram on the Expression and Methylation Levels of Genes Involved in the Oxidative and Nitrosative Stresses as Well as Tryptophan Catabolites Pathway in the Blood and Brain Structures.
Autorzy :
Wigner P; Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Synowiec E; Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Jóźwiak P; Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Czarny P; Department of Medical Biochemistry, Medical University of Lodz, 90-647 Lodz, Poland.
Bijak M; Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Białek K; Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Szemraj J; Department of Medical Biochemistry, Medical University of Lodz, 90-647 Lodz, Poland.
Gruca P; Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.
Papp M; Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.
Śliwiński T; Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 22; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 22.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*drug effects
Citalopram/*pharmacology
DNA Methylation/*drug effects
Gene Expression Regulation/*drug effects
Metabolic Networks and Pathways/*genetics
Stress, Psychological/*physiopathology
Tryptophan/*metabolism
Animals ; Antidepressive Agents, Second-Generation/pharmacology ; Brain/metabolism ; Catalase/genetics ; Catalase/metabolism ; Chronic Disease ; Depression/genetics ; Depression/metabolism ; Glutathione Peroxidase/genetics ; Glutathione Peroxidase/metabolism ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Male ; Nitric Oxide Synthase Type I/genetics ; Nitric Oxide Synthase Type I/metabolism ; Nitrosative Stress ; Oxidative Stress ; Rats, Wistar ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/metabolism
Czasopismo naukowe
Tytuł :
Scalable continuous evolution for the generation of diverse enzyme variants encompassing promiscuous activities.
Autorzy :
Rix G; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA.
Watkins-Dulaney EJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Almhjell PJ; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
Boville CE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Aralez Bio, Emeryville, CA, USA.
Arnold FH; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
Liu CC; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA. .; Department of Biomedical Engineering, University of California, Irvine, CA, USA. .; Department of Chemistry, University of California, Irvine, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 06; Vol. 11 (1), pp. 5644. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Bacterial Proteins/*chemistry
Bacterial Proteins/*metabolism
Thermotoga maritima/*enzymology
Tryptophan Synthase/*chemistry
Bacterial Proteins/genetics ; Biocatalysis ; Evolution, Molecular ; Mutation ; Protein Subunits/chemistry ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Substrate Specificity ; Thermotoga maritima/chemistry ; Thermotoga maritima/genetics ; Tryptophan/chemistry ; Tryptophan/metabolism ; Tryptophan Synthase/genetics ; Tryptophan Synthase/metabolism
Czasopismo naukowe
Tytuł :
The Impact of Chronic Mild Stress and Agomelatine Treatment on the Expression Level and Methylation Status of Genes Involved in Tryptophan Catabolic Pathway in PBMCs and Brain Structures.
Autorzy :
Wigner P; Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
Synowiec E; Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
Jóźwiak P; Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
Czarny P; Department of Medical Biochemistry, Medical University of Lodz, 92-216 Lodz, Poland.
Białek K; Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
Bijak M; Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
Szemraj J; Department of Medical Biochemistry, Medical University of Lodz, 92-216 Lodz, Poland.
Gruca P; Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.
Papp M; Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.
Sliwinski T; Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
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Źródło :
Genes [Genes (Basel)] 2020 Sep 18; Vol. 11 (9). Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Acetamides/*pharmacology
Brain/*pathology
Gene Expression Regulation/*drug effects
Leukocytes, Mononuclear/*pathology
Stress, Psychological/*physiopathology
Tryptophan/*metabolism
Acetyltransferases/genetics ; Acetyltransferases/metabolism ; Animals ; Brain/drug effects ; Brain/metabolism ; Chronic Disease ; Hypnotics and Sedatives/pharmacology ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Male ; Rats ; Rats, Wistar ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/metabolism
Czasopismo naukowe
Tytuł :
Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis.
Autorzy :
Lercher A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse, Vienna, Austria.
Popa AM; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse, Vienna, Austria.
Viczenczova C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse, Vienna, Austria.
Kosack L; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse, Vienna, Austria.
Klavins K; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse, Vienna, Austria.
Agerer B; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse, Vienna, Austria.
Opitz CA; DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Neurology Clinic and National Center for Tumor Diseases, University Hospital of Heidelberg, Heidelberg, Germany.
Lanz TV; Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America.; Department of Neurology, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.
Platten M; Department of Neurology, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Bergthaler A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse, Vienna, Austria.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Oct 12; Vol. 16 (10), pp. e1008973. Date of Electronic Publication: 2020 Oct 12 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*metabolism
Hepatitis, Viral, Animal/*immunology
Hepatocytes/*immunology
Inflammation/*immunology
Kynurenine/*metabolism
Receptor, Interferon alpha-beta/*physiology
Tryptophan/*metabolism
Animals ; Female ; Hepatitis Viruses/isolation & purification ; Hepatitis, Viral, Animal/metabolism ; Hepatitis, Viral, Animal/virology ; Hepatocytes/metabolism ; Hepatocytes/virology ; Humans ; Immunity, Innate/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation/virology ; Interferon Regulatory Factor-7/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; STAT1 Transcription Factor/physiology ; Tryptophan Oxygenase/physiology
Czasopismo naukowe
Tytuł :
Kinetic and Spectroscopic Characterization of the Catalytic Ternary Complex of Tryptophan 2,3-Dioxygenase.
Autorzy :
Geng J; Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States.
Weitz AC; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.
Dornevil K; Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States.; Department of Chemistry, University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Hendrich MP; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.
Liu A; Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States.; Department of Chemistry, University of Texas at San Antonio, San Antonio, Texas 78249, United States.
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Źródło :
Biochemistry [Biochemistry] 2020 Aug 04; Vol. 59 (30), pp. 2813-2822. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Biocatalysis*
Tryptophan Oxygenase/*chemistry
Cupriavidus/enzymology ; Isotopes ; Kinetics ; Spectrophotometry, Ultraviolet ; Spectroscopy, Mossbauer ; Spectrum Analysis ; Time Factors ; Tryptophan/metabolism
SCR Organism :
Cupriavidus metallidurans
Czasopismo naukowe
Tytuł :
Auxin biosynthesis in the phytopathogenic fungus Leptosphaeria maculans is associated with enhanced transcription of indole-3-pyruvate decarboxylase LmIPDC2 and tryptophan aminotransferase LmTAM1.
Autorzy :
Leontovyčová H; Laboratory of Pathological Plant Physiology, Institute of Experimental Botany of the Czech Academy of Sciences, Rozvojová 313, 165 02, Prague, Czech Republic; Department of Biochemistry, Faculty of Science, Charles University, Hlavova 8, 128 43, Prague, Czech Republic. Electronic address: .
Trdá L; Laboratory of Pathological Plant Physiology, Institute of Experimental Botany of the Czech Academy of Sciences, Rozvojová 313, 165 02, Prague, Czech Republic. Electronic address: .
Dobrev PI; Laboratory of Hormonal Regulations in Plants, Institute of Experimental Botany of the Czech Academy of Sciences, Rozvojová 263, 165 02, Prague, Czech Republic. Electronic address: .
Šašek V; Laboratory of Pathological Plant Physiology, Institute of Experimental Botany of the Czech Academy of Sciences, Rozvojová 313, 165 02, Prague, Czech Republic. Electronic address: .
Gay E; UMR BIOGER, INRAE AgroParisTech Université Paris Saclay, Avenue Lucien Brétignières, BP 01, 78850, Thiverval-Grignon, France. Electronic address: .
Balesdent MH; UMR BIOGER, INRAE AgroParisTech Université Paris Saclay, Avenue Lucien Brétignières, BP 01, 78850, Thiverval-Grignon, France. Electronic address: .
Burketová L; Laboratory of Pathological Plant Physiology, Institute of Experimental Botany of the Czech Academy of Sciences, Rozvojová 313, 165 02, Prague, Czech Republic. Electronic address: .
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Źródło :
Research in microbiology [Res Microbiol] 2020 Jul - Sep; Vol. 171 (5-6), pp. 174-184. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Carboxy-Lyases/*genetics
Indoleacetic Acids/*metabolism
Leptosphaeria/*metabolism
Plant Growth Regulators/*metabolism
Tryptophan Transaminase/*genetics
Aminohydrolases/genetics ; Biosynthetic Pathways ; Brassica napus/microbiology ; Carboxy-Lyases/metabolism ; Fungi/classification ; Fungi/genetics ; Fungi/metabolism ; Gene Expression Regulation, Fungal ; Indoleacetic Acids/pharmacology ; Leptosphaeria/enzymology ; Leptosphaeria/genetics ; Leptosphaeria/growth & development ; Phylogeny ; Transcription, Genetic ; Tryptamines/metabolism ; Tryptamines/pharmacology ; Tryptophan/metabolism ; Tryptophan/pharmacology ; Tryptophan Transaminase/metabolism ; Up-Regulation
SCR Organism :
Leptosphaeria maculans
Czasopismo naukowe
Tytuł :
Natural Products Originated from the Oxidative Coupling of Tyrosine and Tryptophan: Biosynthesis and Bioinspired Synthesis.
Autorzy :
Tang S; Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Saclay, CNRS, 91405, Orsay, France.
Vincent G; Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Saclay, CNRS, 91405, Orsay, France.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Feb 05; Vol. 27 (8), pp. 2612-2622. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Oxidative Coupling*
Biological Products/*chemical synthesis
Biological Products/*metabolism
Tryptophan/*metabolism
Tyrosine/*metabolism
Animals ; Biological Products/chemistry ; Tryptophan/chemistry ; Tyrosine/chemistry
Czasopismo naukowe
Tytuł :
Novel Arylindigoids by Late-Stage Derivatization of Biocatalytically Synthesized Dibromoindigo.
Autorzy :
Schnepel C; Organische und Bioorganische Chemie, Fakultät für Chemie, Universität Bielefeld, Universitätsstraße 25, 33615, Bielefeld, Germany.; Present address: School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
Dodero VI; Organische und Bioorganische Chemie, Fakultät für Chemie, Universität Bielefeld, Universitätsstraße 25, 33615, Bielefeld, Germany.
Sewald N; Organische und Bioorganische Chemie, Fakultät für Chemie, Universität Bielefeld, Universitätsstraße 25, 33615, Bielefeld, Germany.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Mar 22; Vol. 27 (17), pp. 5404-5411. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Halogenation*
Tryptophan*/metabolism
Biocatalysis ; Flavins ; Halogens
Czasopismo naukowe
Tytuł :
Interactions of Designed Trp-Containing Antimicrobial Peptides with DNA of Multidrug-Resistant Pseudomonas aeruginosa .
Autorzy :
Han X; School of Life Science, Liaoning Normal University, Dalian, China.
Kou Z; School of Life Science, Liaoning Normal University, Dalian, China.
Jiang F; Department of Clinical Laboratory, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
Sun X; School of Life Science, Liaoning Normal University, Dalian, China.
Shang D; School of Life Science, Liaoning Normal University, Dalian, China.; Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian, China.
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Źródło :
DNA and cell biology [DNA Cell Biol] 2021 Feb; Vol. 40 (2), pp. 414-424. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Tryptophan*
DNA/*metabolism
Drug Resistance, Multiple/*drug effects
Pore Forming Cytotoxic Proteins/*chemistry
Pore Forming Cytotoxic Proteins/*pharmacology
Pseudomonas aeruginosa/*drug effects
Microbial Sensitivity Tests ; Pore Forming Cytotoxic Proteins/metabolism
Czasopismo naukowe
Tytuł :
Gene expression of indoleamine and tryptophan dioxygenases and three long non-coding RNAs in breast cancer.
Autorzy :
Ghafouri-Fard S; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Taherian-Esfahani Z; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dashti S; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Kholghi Oskooei V; Department of Laboratory Sciences, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran; Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Taheri M; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: .
Samsami M; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: .
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Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2020 Jun; Vol. 114, pp. 104415. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*genetics
RNA, Long Noncoding/*genetics
Tryptophan Oxygenase/*genetics
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Breast Neoplasms/pathology ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoles/metabolism ; Kynurenine/metabolism ; Metabolic Networks and Pathways/genetics ; MicroRNAs/genetics ; Middle Aged ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł :
The Uniqueness of Tryptophan in Biology: Properties, Metabolism, Interactions and Localization in Proteins.
Autorzy :
Barik S; 3780 Pelham Drive, Mobile, AL 36619, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 20; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Dipeptides/*metabolism
Indolequinones/*metabolism
Indoles/*metabolism
Kynurenine/*metabolism
Serotonin/*metabolism
Tryptophan/*analogs & derivatives
Tryptophan/*metabolism
Animals ; Codon ; Dipeptides/chemistry ; Humans ; Hydrophobic and Hydrophilic Interactions ; Indolequinones/chemistry ; Indoles/chemistry ; Kynurenine/chemistry ; Protein Biosynthesis ; Protein Interaction Domains and Motifs ; Proteins/chemistry ; Proteins/genetics ; Proteins/metabolism ; Serotonin/chemistry ; Structure-Activity Relationship ; Thermodynamics ; Tryptophan/chemistry ; Tryptophan/genetics
Czasopismo naukowe
Tytuł :
Simultaneous determination of 30 neurologically and metabolically important molecules: A sensitive and selective way to measure tyrosine and tryptophan pathway metabolites and other biomarkers in human serum and cerebrospinal fluid.
Autorzy :
Galla Z; Metabolic and Newborn Screening Laboratory, Department of Paediatrics, University of Szeged. Electronic address: .
Rajda C; Department of Neurology, University of Szeged, Hungary.
Rácz G; Metabolic and Newborn Screening Laboratory, Department of Paediatrics, University of Szeged.
Grecsó N; Metabolic and Newborn Screening Laboratory, Department of Paediatrics, University of Szeged.
Baráth Á; Metabolic and Newborn Screening Laboratory, Department of Paediatrics, University of Szeged.
Vécsei L; Department of Neurology, University of Szeged, Hungary; Department of Neurology, MTA-SZTE Neuroscience Research Group, Interdisciplinary Excellence Centre, Faculty of Medicine, Universtiy of Szeged, Hungary.
Bereczki C; Metabolic and Newborn Screening Laboratory, Department of Paediatrics, University of Szeged.
Monostori P; Metabolic and Newborn Screening Laboratory, Department of Paediatrics, University of Szeged.
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Jan 04; Vol. 1635, pp. 461775. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers/*analysis
Clinical Chemistry Tests/*methods
Tryptophan/*analysis
Tyrosine/*analysis
Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Chromatography, High Pressure Liquid ; Clinical Chemistry Tests/standards ; Humans ; Metabolic Networks and Pathways ; Reproducibility of Results ; Spectrometry, Mass, Electrospray Ionization ; Tryptophan/blood ; Tryptophan/cerebrospinal fluid ; Tyrosine/blood ; Tyrosine/cerebrospinal fluid
Czasopismo naukowe
Tytuł :
Metabolic Stress and Immunity: Nutrient-Sensing Kinases and Tryptophan Metabolism.
Autorzy :
Gostner JM; Institute of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Fuchs D; Institute of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Kurz K; Department of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria. .
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1275, pp. 395-405.
Typ publikacji :
Journal Article
MeSH Terms :
Protein-Serine-Threonine Kinases*
Tryptophan*
Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Kynurenine ; Nutrients ; Stress, Physiological
Czasopismo naukowe
Tytuł :
Dietary intake of tryptophan tied emotion-related impulsivity in humans.
Autorzy :
Javelle F; University of California Berkeley, Berkeley, USA.
Li D; University of California San Francisco, San Francisco, USA.
Zimmer P; Clinical Exercise-Neuro-Immunology group, Dpt. for molecular and cellular Sports Medicine, Institute for Cardiovascular Research and Sports Medicine, German Sport University, Köln, Germany.
Johnson SL; University of California Berkeley, Berkeley, USA.
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Źródło :
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition [Int J Vitam Nutr Res] 2021 Jan; Vol. 91 (1-2), pp. 69-76. Date of Electronic Publication: 2019 Oct 04.
Typ publikacji :
Journal Article
MeSH Terms :
Impulsive Behavior*
Tryptophan*
Eating ; Emotions ; Female ; Humans ; Male ; Vitamin B 6
Czasopismo naukowe
Tytuł :
Clinical significance of tryptophan catabolism in follicular lymphoma.
Autorzy :
Masaki A; Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.; Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Ishida T; Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.; Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Maeda Y; Center for Joint Research Facilities Support, Fujita Health University, Toyoake, Japan.
Ito A; Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Suzuki S; Department of Tumor Immunology, Aichi Medical University School of Medicine, Nagakute, Japan.
Narita T; Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Kinoshita S; Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Yoshida T; Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Ri M; Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Kusumoto S; Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Komatsu H; Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Inagaki H; Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Ueda R; Department of Tumor Immunology, Aichi Medical University School of Medicine, Nagakute, Japan.
Choi I; Department of Hematology, National Kyushu Cancer Center, Fukuoka, Japan.
Suehiro Y; Department of Hematology, National Kyushu Cancer Center, Fukuoka, Japan.
Iida S; Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
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Źródło :
Hematological oncology [Hematol Oncol] 2020 Dec; Vol. 38 (5), pp. 742-753. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Lymphoma, Follicular/*metabolism
Tryptophan/*metabolism
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor ; Female ; Humans ; Immunohistochemistry ; Kynurenine/blood ; Kynurenine/metabolism ; Lymphatic Metastasis ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/mortality ; Lymphoma, Follicular/therapy ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Tryptophan/blood ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Effects of tryptophan and probiotic supplementation on growth and behavior in quail.
Autorzy :
Yıldırım A; Department of Animal Science, Faculty of Agriculture, Tokat Gaziosmanpasa University, 60000 Tokat, Turkey.
Kraimi N; UMR85 Physiologie de la Reproduction et des Comportements, INRAE, CNRS, IFCE, Université de Tours, Center Val de Loire, 37380 Nouzilly, France.
Constantin P; UMR85 Physiologie de la Reproduction et des Comportements, INRAE, CNRS, IFCE, Université de Tours, Center Val de Loire, 37380 Nouzilly, France.
Mercerand F; UE PEAT, INRAE, Center Val de Loire, 37380 Nouzilly, France.
Leterrier C; UMR85 Physiologie de la Reproduction et des Comportements, INRAE, CNRS, IFCE, Université de Tours, Center Val de Loire, 37380 Nouzilly, France. Electronic address: .
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Źródło :
Poultry science [Poult Sci] 2020 Nov; Vol. 99 (11), pp. 5206-5213. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article
MeSH Terms :
Behavior, Animal*/drug effects
Coturnix*/growth & development
Dietary Supplements*
Probiotics*/pharmacology
Tryptophan*/pharmacology
Animal Feed/analysis ; Animals ; Diet/veterinary ; Female ; Male
Czasopismo naukowe
Tytuł :
Evaluation and comparison of the commonly used bioassays of human indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO).
Autorzy :
Zhang S; State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Songhu Road 2005, Shanghai 200438, China. Electronic address: .
Guo L; State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Songhu Road 2005, Shanghai 200438, China. Electronic address: .
Yang D; State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Songhu Road 2005, Shanghai 200438, China. Electronic address: .
Xing Z; State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Songhu Road 2005, Shanghai 200438, China. Electronic address: .
Li W; State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Songhu Road 2005, Shanghai 200438, China. Electronic address: .
Kuang C; Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, 200092 Shanghai, China. Electronic address: .
Yang Q; State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Songhu Road 2005, Shanghai 200438, China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104348. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Inhibitors/*pharmacology
Indoleamine-Pyrrole 2,3,-Dioxygenase/*antagonists & inhibitors
Tryptophan Oxygenase/*antagonists & inhibitors
Biological Assay ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; HEK293 Cells ; HeLa Cells ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Molecular Structure ; Recombinant Proteins/metabolism ; Structure-Activity Relationship ; Tryptophan Oxygenase/metabolism
Czasopismo naukowe
Tytuł :
Role of Indoleamine-2,3-Dioxygenase Inhibitors in Salvage Therapy for Non-Muscle Invasive Bladder Cancer.
Autorzy :
Chu CE; Department of Urology, University of California, San Francisco, 550 16th Street, 6th Floor, San Francisco, CA 94143, USA.
Porten SP; Department of Urology, University of California, San Francisco, 550 16th Street, 6th Floor, San Francisco, CA 94143, USA.
Grossfeld GD; Bristol-Myers Squibb, 3401 Princeton Pike, Lawrenceville, New Jersey 08648, USA.
Meng MV; Department of Urology, University of California, San Francisco, 550 16th Street, 6th Floor, San Francisco, CA 94143, USA. Electronic address: .
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Źródło :
The Urologic clinics of North America [Urol Clin North Am] 2020 Feb; Vol. 47 (1), pp. 111-118.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Acetamides/*administration & dosage
Indoleamine-Pyrrole 2,3,-Dioxygenase/*antagonists & inhibitors
Oximes/*administration & dosage
Quinolines/*administration & dosage
Salvage Therapy/*methods
Sulfonamides/*administration & dosage
Tryptophan/*analogs & derivatives
Urinary Bladder Neoplasms/*therapy
Administration, Intravesical ; Enzyme Inhibitors/administration & dosage ; Humans ; Neoplasm Invasiveness ; Treatment Outcome ; Tryptophan/administration & dosage ; Tryptophan Oxygenase ; Urinary Bladder Neoplasms/immunology ; Urinary Bladder Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei.
Autorzy :
Cockram PE; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Scotland.
Dickie EA; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Barrett MP; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Smith TK; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Scotland.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Dec 04; Vol. 14 (12), pp. e0008928. Date of Electronic Publication: 2020 Dec 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Trypanosoma brucei brucei/*metabolism
Tryptophan/*metabolism
Amino Acids/chemistry ; Amino Acids/metabolism ; Cell Survival ; HeLa Cells ; Humans ; Leishmania major ; Molecular Structure ; Tryptophan/chemistry
Czasopismo naukowe

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