- Tytuł :
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Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma. - Autorzy :
- Źródło :
- Cancer science [Cancer Sci] 2021 Mar; Vol. 112 (3), pp. 1038-1047. Date of Electronic Publication: 2021 Jan 25.
- Typ publikacji :
- Journal Article
- MeSH Terms :
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Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Carcinoma, Renal Cell/*therapy
Kidney/*pathology
Kidney Neoplasms/*therapyTryptophan Oxygenase/*metabolism
Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Renal Cell/mortality ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Chemotherapy, Adjuvant ; Disease Progression ; Drug Resistance, Neoplasm ; Female ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Immunohistochemistry ; Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Kidney/surgery ; Kidney Neoplasms/mortality ; Kidney Neoplasms/pathology ; Kynurenine/analysis ; Kynurenine/metabolism ; Male ; Middle Aged ; Nephrectomy ; Progression-Free Survival ;Tryptophan /metabolism ;Tryptophan Oxygenase/analysis ;Tryptophan Oxygenase/antagonists & inhibitors -
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