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Tytuł:
Single Cell Analysis of the Fate of Injected Oncogenic RasV12 Cells in Adult Wild Type Drosophila.
Autorzy:
Chen D; Sino-French Hoffmann Institute, School of Basic Medical Science, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Lan X; Sino-French Hoffmann Institute, School of Basic Medical Science, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Huang X; Sino-French Hoffmann Institute, School of Basic Medical Science, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Huang J; Sino-French Hoffmann Institute, School of Basic Medical Science, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Zhou X; Sino-French Hoffmann Institute, School of Basic Medical Science, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Miao Z; Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou, China.; Translational Research Institute of Brain and Brain-Like Intelligence and Department of Anesthesiology, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Ma Y; Institute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Suzhou Institute of Systems Medicine, Suzhou, China.
Goto A; Université de Strasbourg and CNRS, Insect Models of Innate Immunity (M3I; UPR9022), Strasbourg, France.
Ji S; Université de Strasbourg and CNRS, Insect Models of Innate Immunity (M3I; UPR9022), Strasbourg, France.
Hoffmann JA; Sino-French Hoffmann Institute, School of Basic Medical Science, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.; Université de Strasbourg and CNRS, Insect Models of Innate Immunity (M3I; UPR9022), Strasbourg, France.; University of Strasbourg Institute for Advanced Study, Strasbourg, France.
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Źródło:
Journal of innate immunity [J Innate Immun] 2023; Vol. 15 (1), pp. 442-467. Date of Electronic Publication: 2023 Mar 30.
Typ publikacji:
Journal Article
MeSH Terms:
Drosophila melanogaster*
Single-Cell Gene Expression Analysis*
Tumor Cells, Cultured*
Male ; Animals ; Inflammation ; Signal Transduction ; Phagocytosis ; Antimicrobial Peptides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cellular Effects of Selected Unsymmetrical Bisacridines on the Multicellular Tumor Spheroids of HCT116 Colon and A549 Lung Cancer Cells in Comparison to Monolayer Cultures.
Autorzy:
Kulesza J; Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, 80-233 Gdańsk, Poland.
Paluszkiewicz E; Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, 80-233 Gdańsk, Poland.
Augustin E; Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, 80-233 Gdańsk, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 30; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 30.
Typ publikacji:
Journal Article
MeSH Terms:
Lung Neoplasms*/metabolism
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/metabolism
Humans ; Spheroids, Cellular ; Tumor Cells, Cultured ; Neoplastic Stem Cells/metabolism ; Colon ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Novel conditionally replicating adenovirus-mediated efficient detection of circulating tumor cells in lung cancer patients.
Autorzy:
Ikemoto S; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Sakurai F; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Tokuoka S; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Yamashita T; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Takayama K; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Hoshi K; Department of Minimally Invasive Next-generation Cancer Diagnosis by TelomeScan, Tokyo, Japan.; Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan.
Okabe T; Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan.
Sumiyoshi I; Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan.
Togo S; Department of Minimally Invasive Next-generation Cancer Diagnosis by TelomeScan, Tokyo, Japan.; Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan.
Takahashi K; Department of Minimally Invasive Next-generation Cancer Diagnosis by TelomeScan, Tokyo, Japan.; Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan.
Tachibana M; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.; The Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan.
Mizuguchi H; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.; The Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan.; Center for Infectious Disease Education and Research (CiDER), Osaka University, Osaka, Japan.; Laboratory of Functional Organoid for Drug Discovery, Center for Drug Discovery Resources Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Osaka, Japan.
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Źródło:
PloS one [PLoS One] 2023 Oct 19; Vol. 18 (10), pp. e0286323. Date of Electronic Publication: 2023 Oct 19 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Neoplastic Cells, Circulating*/pathology
Lung Neoplasms*/genetics
Lung Neoplasms*/pathology
Humans ; Adenoviridae/physiology ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Tumor Cells, Cultured ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer.
Autorzy:
Di Donato M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Di Zazzo E; Department of Medicine and Health Sciences 'V. Tiberio', University of Molise, Campobasso, Italy.
Salvati A; Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081, Baronissi, Italy.
Sorrentino C; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Giurato G; Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081, Baronissi, Italy.; CRGS-Genome Research Center for Health, University of Salerno Campus of Medicine, 84081, Baronissi, Italy.
Fiore D; Department of Pharmacy, University of Salerno, Fisciano, Italy.
Proto MC; Department of Pharmacy, University of Salerno, Fisciano, Italy.
Rienzo M; Department of Environmental, Biological, and Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', Caserta, Italy.
Casamassimi A; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy. .
Gazzerro P; Department of Pharmacy, University of Salerno, Fisciano, Italy.
Bifulco M; Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', Naples, Italy.
Castoria G; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Weisz A; Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081, Baronissi, Italy.; CRGS-Genome Research Center for Health, University of Salerno Campus of Medicine, 84081, Baronissi, Italy.
Nassa G; Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081, Baronissi, Italy.; CRGS-Genome Research Center for Health, University of Salerno Campus of Medicine, 84081, Baronissi, Italy.
Abbondanza C; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Oct 18; Vol. 21 (1), pp. 736. Date of Electronic Publication: 2023 Oct 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms*/genetics
Epidermal Growth Factor*
Humans ; Cell Line, Tumor ; ErbB Receptors ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Induction of Drug-Resistance and Production of a Culture Medium Able to Induce Drug-Resistance in Vinblastine Untreated Murine Myeloma Cells.
Autorzy:
Masci VL; Laboratory of Plant Cytology and Biotechnology of Natural Compounds, Department for the Innovation in Biological, Agri-Food and Forestal Systems, University of Tuscia, Largo dell'Università, snc, 01100 Viterbo, Italy.
Stefanoni D; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Zambelli M; Laboratory of Plant Cytology and Biotechnology of Natural Compounds, Department for the Innovation in Biological, Agri-Food and Forestal Systems, University of Tuscia, Largo dell'Università, snc, 01100 Viterbo, Italy.
Modesti L; Laboratory of Plant Cytology and Biotechnology of Natural Compounds, Department for the Innovation in Biological, Agri-Food and Forestal Systems, University of Tuscia, Largo dell'Università, snc, 01100 Viterbo, Italy.; Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.
Pollini D; Laboratory of Plant Cytology and Biotechnology of Natural Compounds, Department for the Innovation in Biological, Agri-Food and Forestal Systems, University of Tuscia, Largo dell'Università, snc, 01100 Viterbo, Italy.; Department of Cellular, Computational and Integrative Biology, University of Trento, 38123 Trento, Italy.
Ovidi E; Laboratory of Plant Cytology and Biotechnology of Natural Compounds, Department for the Innovation in Biological, Agri-Food and Forestal Systems, University of Tuscia, Largo dell'Università, snc, 01100 Viterbo, Italy.
Tiezzi A; Laboratory of Plant Cytology and Biotechnology of Natural Compounds, Department for the Innovation in Biological, Agri-Food and Forestal Systems, University of Tuscia, Largo dell'Università, snc, 01100 Viterbo, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 22; Vol. 28 (5). Date of Electronic Publication: 2023 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Vinblastine*/pharmacology
Multiple Myeloma*
Mice ; Humans ; Animals ; Drug Resistance, Neoplasm ; Tumor Cells, Cultured ; Neoplasm Recurrence, Local
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Novel Preclinical In Vitro 3D Model of Oral Carcinogenesis for Biomarker Discovery and Drug Testing.
Autorzy:
Chitturi Suryaprakash RT; UWA Dental School, The University of Western Australia, Nedlands, WA 6009, Australia.
Shearston K; UWA Dental School, The University of Western Australia, Nedlands, WA 6009, Australia.
Farah CS; Australian Centre for Oral Oncology Research and Education, Nedlands, WA 6009, Australia.
Fox SA; UWA Dental School, The University of Western Australia, Nedlands, WA 6009, Australia.; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, WA 6009, Australia.
Iqbal MM; Genomics WA, Harry Perkins Institute of Medical Research, Telethon Kids Institute, The University of Western Australia, Nedlands, WA 6009, Australia.
Kadolsky U; Genomics WA, Harry Perkins Institute of Medical Research, Telethon Kids Institute, The University of Western Australia, Nedlands, WA 6009, Australia.
Zhong X; Genomics WA, Harry Perkins Institute of Medical Research, Telethon Kids Institute, The University of Western Australia, Nedlands, WA 6009, Australia.
Saxena A; Genomics WA, Harry Perkins Institute of Medical Research, Telethon Kids Institute, The University of Western Australia, Nedlands, WA 6009, Australia.
Kujan O; UWA Dental School, The University of Western Australia, Nedlands, WA 6009, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 17; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 17.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinogenesis*/drug effects
Carcinogenesis*/metabolism
Mouth Neoplasms*/chemically induced
Mouth Neoplasms*/metabolism
Cell Culture Techniques, Three Dimensional*
Biomarkers, Tumor*/genetics
Biomarkers, Tumor*/metabolism
Spheroids, Cellular*
Antineoplastic Agents*/pharmacology
Humans ; Carcinogens/pharmacology ; Squamous Cell Carcinoma of Head and Neck ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Drug Screening Assays, Antitumor ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Simple Detection and Culture of Circulating Tumor Cells from Colorectal Cancer Patients Using Poly(2-Methoxyethyl Acrylate)-Coated Plates.
Autorzy:
Nomura M; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Yokoyama Y; Department of Molecular Pathology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Yoshimura D; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Minagawa Y; Department of Planning & Administration, Headquarters of Research & Development, Sumitomo Rubber Industries, Ltd., Kobe 651-0071, Japan.
Yamamoto A; Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka 819-0395, Japan.
Tanaka Y; Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka 819-0395, Japan.
Sekiguchi N; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Marukawa D; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Ichihara M; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Itakura H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Matsumoto K; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Morimoto Y; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Tomihara H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Inoue A; Department of Gastroenterological Surgery, Osaka General Medical Center, Osaka 558-8558, Japan.
Ogino T; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Miyoshi N; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Takahashi H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Takahashi H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Uemura M; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Kobayashi S; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Mizushima T; Department of Gastroenterological Surgery, Osaka Police Hospital, Osaka 543-0035, Japan.
Anada T; Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka 819-0395, Japan.
Mori M; Graduate School of Medicine, Tokai University, Isehara 259-1193, Japan.
Doki Y; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Tanaka M; Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka 819-0395, Japan.
Eguchi H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Yamamoto H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.; Department of Molecular Pathology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 16; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms*/pathology
Neoplastic Cells, Circulating*/pathology
Humans ; Acrylates/chemistry ; Polymers/chemistry ; Tumor Cells, Cultured ; Cell Culture Techniques
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluating the reliability of tumour spheroid-on-chip models for replicating intratumoural drug delivery: considering the role of microfluidic parameters.
Autorzy:
Besanjideh M; Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.; Stem Cell and Regenerative Medicine Institute, Sharif University of Technology, Tehran, Iran.
Shamloo A; Stem Cell and Regenerative Medicine Institute, Sharif University of Technology, Tehran, Iran.
Hannani SK; Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.
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Źródło:
Journal of drug targeting [J Drug Target] 2023 Feb; Vol. 31 (2), pp. 179-193. Date of Electronic Publication: 2022 Sep 20.
Typ publikacji:
Journal Article
MeSH Terms:
Lab-On-A-Chip Devices*
Neoplasms*/drug therapy
Humans ; Microfluidics ; Reproducibility of Results ; Spheroids, Cellular ; Drug Delivery Systems ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mathematical modelling reveals cellular dynamics within tumour spheroids.
Autorzy:
Bull JA; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom.
Mech F; Roche Pharma Research and Early Development, pRED Informatics, Roche Innovation Centre Munich, Germany.
Quaiser T; Roche Pharma Research and Early Development, pRED Informatics, Roche Innovation Centre Munich, Germany.
Waters SL; Oxford Centre for Industrial and Applied Mathematics, Mathematical Institute, University of Oxford, Oxford, United Kingdom.
Byrne HM; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2020 Aug 18; Vol. 16 (8), pp. e1007961. Date of Electronic Publication: 2020 Aug 18 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Spheroids, Cellular*/cytology
Spheroids, Cellular*/physiology
Tumor Cells, Cultured*/cytology
Tumor Cells, Cultured*/physiology
Animals ; Biomechanical Phenomena ; Cell Death/physiology ; Cell Hypoxia/physiology ; Cell Proliferation/physiology ; Computational Biology ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antiproliferative effects of sulphonamide carbonic anhydrase inhibitors C18, SLC-0111 and acetazolamide on bladder, glioblastoma and pancreatic cancer cell lines.
Autorzy:
Mussi S; Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Rezzola S; Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Chiodelli P; Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Nocentini A; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Sesto Fiorentino, Florence, Italy.
Supuran CT; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Sesto Fiorentino, Florence, Italy.
Ronca R; Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 280-286.
Typ publikacji:
Journal Article
MeSH Terms:
Acetazolamide/*pharmacology
Antineoplastic Agents/*pharmacology
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Sulfonamides/*pharmacology
Acetazolamide/chemical synthesis ; Acetazolamide/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation.
Autorzy:
Chaudhary CL; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Lim D; Innovo Therapeutics Inc, Daejeon, Republic of Korea.
Chaudhary P; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Guragain D; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Awasthi BP; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Park HD; Innovo Therapeutics Inc, Daejeon, Republic of Korea.
Kim JA; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Jeong BS; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 844-856.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Antineoplastic Agents/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Pyridines/*pharmacology
Pyrimidines/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Chickens ; Dose-Response Relationship, Drug ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/pathology ; Models, Molecular ; Molecular Structure ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Osthole exhibits an antitumor effect in retinoblastoma through inhibiting the PI3K/AKT/mTOR pathway via regulating the hsa_circ_0007534/miR-214-3p axis.
Autorzy:
Lv X; Department of Ophthalmology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Yang H; Department of Ophthalmology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Zhong H; Department of Ophthalmology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
He L; Department of Ophthalmology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Wang L; Department of Ophthalmology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 417-426.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Phytogenic/*pharmacology
Coumarins/*pharmacology
MicroRNAs/*genetics
Retinoblastoma/*drug therapy
Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Apoptosis/drug effects ; Cell Line ; Cell Line, Tumor ; Cell Survival/drug effects ; Coumarins/administration & dosage ; Humans ; Male ; Mice ; Mice, Nude ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Retinoblastoma/genetics ; Retinoblastoma/pathology ; TOR Serine-Threonine Kinases/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Blockade of USP14 potentiates type I interferon signaling and radiation-induced antitumor immunity via preventing IRF3 deubiquitination.
Autorzy:
Wu W; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Xu H; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Liao C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Wang Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Wu R; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Wu J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Zheng W; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Li Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Jin C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Zhao Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Quan J; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Yue X; Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. .; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. .
Bu X; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. .; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2022 Dec; Vol. 45 (6), pp. 1347-1361. Date of Electronic Publication: 2022 Oct 07.
Typ publikacji:
Journal Article
MeSH Terms:
Interferon Type I*/metabolism
Interferon-beta*/metabolism
Ubiquitin Thiolesterase*
Radiotherapy*
Adaptive Immunity*
Humans ; Immunity, Innate ; Interferon Regulatory Factor-3 ; Membrane Proteins/metabolism ; Signal Transduction ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies.
Autorzy:
Khalifa MM; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Al-Karmalawy AA; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.
Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.
Nafie MS; Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
Tantawy MA; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Egypt.; Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo, Egypt.
Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Mahdy HA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 299-314.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Molecular Docking Simulation*
Antineoplastic Agents/*pharmacology
DNA/*chemistry
DNA Topoisomerases, Type II/*metabolism
Phthalazines/*pharmacology
Topoisomerase II Inhibitors/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Phthalazines/chemical synthesis ; Phthalazines/chemistry ; Structure-Activity Relationship ; Topoisomerase II Inhibitors/chemical synthesis ; Topoisomerase II Inhibitors/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibitory effect of roburic acid in combination with docetaxel on human prostate cancer cells.
Autorzy:
Wang X; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.
Xuetao X; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Wu M; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.
Wu P; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Sheng Z; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Liu W; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Ma YY; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Zhao DG; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Zhang K; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Li D; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen City, China.; International Healthcare Innovation Institute (Jiangmen), Jiangmen City, Guangdong Province, China.
Zheng X; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Goodin S; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 542-553.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols*/chemical synthesis
Antineoplastic Combined Chemotherapy Protocols*/chemistry
Antineoplastic Combined Chemotherapy Protocols*/pharmacology
Docetaxel*/chemistry
Docetaxel*/pharmacology
Prostatic Neoplasms*/drug therapy
Prostatic Neoplasms*/metabolism
Prostatic Neoplasms*/pathology
Humans ; Male ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Esomeprazole/chemistry ; Esomeprazole/pharmacology ; Molecular Structure ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.
Autorzy:
Benýšek J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.; First Faculty of Medicine, Charles University, Prague, Czech Republic.
Buša M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
Rubešová P; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Fanfrlík J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Lepšík M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Brynda J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Matoušková Z; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Bartz U; Department of Natural Sciences, University of Applied Sciences Bonn-Rhein-Sieg, Rheinbach, Germany.
Horn M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Gütschow M; Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Germany.
Mareš M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 515-526.
Typ publikacji:
Journal Article
MeSH Terms:
Cathepsin K/*antagonists & inhibitors
Hydrazines/*pharmacology
Nitriles/*pharmacology
Protease Inhibitors/*pharmacology
Cathepsin K/metabolism ; Dose-Response Relationship, Drug ; Humans ; Hydrazines/chemistry ; Models, Molecular ; Molecular Structure ; Nitriles/chemistry ; Protease Inhibitors/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity.
Autorzy:
Fioravanti R; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Rodriguez V; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Caroli J; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Chianese U; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Benedetti R; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Di Bello E; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Noce B; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Zwergel C; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Corinti D; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Viña D; Center for Research in Molecular Medicine and Chronic Disease (CIMUS), Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Altucci L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.; Biogem Institute of Molecular and Genetic Biology, Ariano Irpino, Italy.
Mattevi A; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Valente S; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
Mai A; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 973-985.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Heterocyclic Compounds/*pharmacology
Histone Demethylases/*antagonists & inhibitors
Tranylcypromine/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Heterocyclic Compounds/chemical synthesis ; Heterocyclic Compounds/chemistry ; Histone Demethylases/metabolism ; Humans ; Molecular Structure ; Monoamine Oxidase/metabolism ; Structure-Activity Relationship ; Tranylcypromine/chemical synthesis ; Tranylcypromine/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Discovery of a novel Aurora B inhibitor GSK650394 with potent anticancer and anti- aspergillus fumigatus dual efficacies in vitro .
Autorzy:
He Y; College of Chemistry, Fuzhou University, Fuzhou, China.
Fu W; College of Chemistry, Fuzhou University, Fuzhou, China.
Du L; College of Chemistry, Fuzhou University, Fuzhou, China.
Yao H; College of Chemistry, Fuzhou University, Fuzhou, China.
Hua Z; College of Chemistry, Fuzhou University, Fuzhou, China.
Li J; College of Chemistry, Fuzhou University, Fuzhou, China.
Lin Z; College of Chemistry, Fuzhou University, Fuzhou, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 109-117.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Discovery*
Antifungal Agents/*pharmacology
Antineoplastic Agents/*pharmacology
Aspergillus fumigatus/*drug effects
Aurora Kinase B/*antagonists & inhibitors
Benzoates/*pharmacology
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Antifungal Agents/chemistry ; Antineoplastic Agents/chemistry ; Aurora Kinase B/metabolism ; Benzoates/chemistry ; Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition.
Autorzy:
Xu S; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China.
Fan R; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China.
Wang L; National Center of Colorectal Disease, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, P.R. China.
He W; Biology Department, Boston College, Brighton, MA, USA.
Ge H; School of Life Sciences, Huzhou University, Huzhou, P.R. China.
Chen H; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China.
Xu W; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China.
Zhang J; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China.
Xu W; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China.
Feng Y; School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, P.R. China.
Fan Z; National Center of Colorectal Disease, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, P.R. China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 236-251.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Pentacyclic Triterpenes/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Molecular Structure ; Pentacyclic Triterpenes/chemical synthesis ; Pentacyclic Triterpenes/chemistry ; STAT3 Transcription Factor/metabolism ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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