- Tytuł:
- Sequential cancer mutations in cultured human intestinal stem cells.
- Autorzy:
- Źródło:
- Nature [Nature] 2015 May 07; Vol. 521 (7550), pp. 43-7. Date of Electronic Publication: 2015 Apr 29.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*pathology
Intestines/*pathology
Mutation/*genetics
Organoids/*metabolism
Organoids/*pathology
Stem Cells/*pathology
Aneuploidy ; Animals ; CRISPR-Cas Systems ; Child ; Child, Preschool ; Colorectal Neoplasms/metabolism ; Female ; Genes, APC ; Genes, p53/genetics ; Heterografts ; Humans ; Imidazoles ; Intercellular Signaling Peptides and Proteins/metabolism ; Intestinal Mucosa/metabolism ; Mice ; Middle Aged ; Mutagenesis, Site-Directed ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/pathology ; Neoplasm Transplantation ; Piperazines ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Smad4 Protein/deficiency ; Stem Cell Niche/physiology ; Stem Cells/metabolism
Czasopismo naukowe