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Tytuł:
Single-nucleus chromatin accessibility reveals intratumoral epigenetic heterogeneity in IDH1 mutant gliomas.
Autorzy:
Al-Ali R; Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF 460, 69120, Heidelberg, Germany.; Institute Cochin, INSERM U1016, UMR 8104 CNRS, Faculté René Descartes, 24 rue du Faubourg St Jacques, 75014, Paris, France.
Bauer K; Single-cell Open Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Park JW; Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF 460, 69120, Heidelberg, Germany.
Al Abdulla R; Institute of Research, Development and Innovation in Healthcare Biotechnology in Elche- IDiBE, Elche, Spain.
Fermi V; Division of Experimental Neurosurgery, Department of Neurosurgery, University of Heidelberg, INF 400, D-69120, Heidelberg, Germany.
von Deimling A; Department of Neuropathology, Institute of Pathology, University of Heidelberg, INF 224, D-69120, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Herold-Mende C; Division of Experimental Neurosurgery, Department of Neurosurgery, University of Heidelberg, INF 400, D-69120, Heidelberg, Germany.
Mallm JP; Single-cell Open Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and BioQuant, Heidelberg, Germany.
Herrmann C; Health Data Science Unit, Medical Faculty University Heidelberg and BioQuant, 69120, Heidelberg, Germany.
Wick W; Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF 460, 69120, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Turcan Ş; Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF 460, 69120, Heidelberg, Germany. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2019 Dec 05; Vol. 7 (1), pp. 201. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Neoplasms/*genetics
Cell Nucleus/*genetics
Chromatin/*genetics
Epigenesis, Genetic/*genetics
Glioma/*genetics
Isocitrate Dehydrogenase/*genetics
Brain Neoplasms/pathology ; Cell Nucleus/pathology ; Chromatin/pathology ; Cohort Studies ; Glioma/pathology ; Humans ; Mutation/genetics ; Sequence Analysis, RNA/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IDH-wildtype glioblastomas and grade III/IV IDH-mutant gliomas show elevated tracer uptake in fibroblast activation protein-specific PET/CT.
Autorzy:
Röhrich M; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. .; Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany. .
Loktev A; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Wefers AK; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Altmann A; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.; Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Paech D; Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Adeberg S; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.
Windisch P; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.
Hielscher T; Department of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Flechsig P; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Floca R; Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Leitz D; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Schuster JP; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Molecular Radiooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Huber PE; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Molecular Radiooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Debus J; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.
von Deimling A; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lindner T; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Haberkorn U; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.; Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
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Źródło:
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2019 Nov; Vol. 46 (12), pp. 2569-2580. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji:
Journal Article
MeSH Terms:
Positron Emission Tomography Computed Tomography*
Gelatinases/*metabolism
Glioblastoma/*genetics
Glioblastoma/*pathology
Isocitrate Dehydrogenase/*genetics
Membrane Proteins/*metabolism
Serine Endopeptidases/*metabolism
Acebutolol ; Adult ; Animals ; Biological Transport ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Endopeptidases ; Female ; Glioblastoma/diagnostic imaging ; Glioblastoma/metabolism ; Humans ; Ligands ; Mice ; Middle Aged ; Mutation ; Naphthols ; Neoplasm Grading ; Radioactive Tracers ; Triazines ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry.
Autorzy:
Longuespée R; Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld, 224, Heidelberg, Germany.
Wefers AK; Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld, 224, Heidelberg, Germany.; German Consortium of Translational Cancer Research (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, 280, Heidelberg, Germany.
De Vita E; Cancer Drug Development, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, 280, Heidelberg, Germany.
Miller AK; Cancer Drug Development, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, 280, Heidelberg, Germany.
Reuss DE; Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld, 224, Heidelberg, Germany.; German Consortium of Translational Cancer Research (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, 280, Heidelberg, Germany.
Wick W; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld, 280, Heidelberg, Germany.; Department of Neurology, Heidelberg University Hospital, Im Neuenheimer Feld, 400, Heidelberg, Germany.
Herold-Mende C; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Im Neuenheimer Feld, 400, Heidelberg, Germany.
Kriegsmann M; Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld, 224, Heidelberg, Germany.
Schirmacher P; Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld, 224, Heidelberg, Germany.
von Deimling A; Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld, 224, Heidelberg, Germany.; German Consortium of Translational Cancer Research (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, 280, Heidelberg, Germany.
Pusch S; Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld, 224, Heidelberg, Germany. .; German Consortium of Translational Cancer Research (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, 280, Heidelberg, Germany. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2018 Mar 02; Vol. 6 (1), pp. 21. Date of Electronic Publication: 2018 Mar 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms:
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization*/methods
Brain Neoplasms/*chemistry
Brain Neoplasms/*genetics
Glutarates/*analysis
Isocitrate Dehydrogenase/*genetics
Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Brain/metabolism ; Brain/pathology ; Brain Chemistry ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cryopreservation ; Glioma/chemistry ; Glioma/genetics ; Glioma/metabolism ; Glioma/pathology ; Glutarates/metabolism ; Humans ; Immunohistochemistry ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone.
Autorzy:
Jungk C; Division of Experimental Neurosurgery, Department of Neurosurgery, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. .
Mock A; Division of Experimental Neurosurgery, Department of Neurosurgery, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Exner J; Division of Experimental Neurosurgery, Department of Neurosurgery, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Geisenberger C; Division of Experimental Neurosurgery, Department of Neurosurgery, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Warta R; Division of Experimental Neurosurgery, Department of Neurosurgery, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Capper D; Department of Neuropathology, Heidelberg University Hospital; CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Abdollahi A; Department of Radiation Oncology, Heidelberg University Hospital; Molecular and Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Friauf S; Division of Experimental Neurosurgery, Department of Neurosurgery, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Lahrmann B; Hamamatsu Tissue and Imaging Analysis Center, University of Heidelberg, Heidelberg, Germany.
Grabe N; Hamamatsu Tissue and Imaging Analysis Center, University of Heidelberg, Heidelberg, Germany.
Beckhove P; Division of Translational Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Regensburg Center for Interventional Immunology (RCI), University Hospital, Regensburg, Germany.
von Deimling A; Department of Neuropathology, Heidelberg University Hospital; CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Unterberg A; Division of Experimental Neurosurgery, Department of Neurosurgery, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Herold-Mende C; Division of Experimental Neurosurgery, Department of Neurosurgery, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
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Źródło:
BMC medicine [BMC Med] 2016 Oct 26; Vol. 14 (1), pp. 170. Date of Electronic Publication: 2016 Oct 26.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Neoplasms/*genetics
Glioblastoma/*genetics
Isocitrate Dehydrogenase/*genetics
Receptors, Notch/*metabolism
Aged ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Glioblastoma/therapy ; Humans ; Isocitrate Dehydrogenase/metabolism ; Lateral Ventricles/pathology ; Male ; Middle Aged ; Phenotype ; Prognosis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Notch/genetics ; Signal Transduction ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A vaccine targeting mutant IDH1 induces antitumour immunity.
Autorzy:
Schumacher T; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [3].
Bunse L; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [3].
Pusch S; 1] Department of Neuropathology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Sahm F; 1] Department of Neuropathology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Wiestler B; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Quandt J; Department of Translational Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Menn O; Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany.
Osswald M; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Oezen I; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Ott M; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Keil M; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Balß J; 1] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Rauschenbach K; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Grabowska AK; Department of Immunotherapy and -prevention Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Vogler I; Ribological GmbH, 55131 Mainz, Germany.
Diekmann J; Translational Oncology, 55131 Mainz, Germany.
Trautwein N; Department of Immunology, University of Tübingen, 72076 Tübingen, Germany.
Eichmüller SB; Department of Translational Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Okun J; Metabolic Centre Heidelberg, University Children's Hospital, 69120 Heidelberg, Germany.
Stevanović S; Department of Immunology, University of Tübingen, 72076 Tübingen, Germany.
Riemer AB; Department of Immunotherapy and -prevention Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Sahin U; Translational Oncology, 55131 Mainz, Germany.
Friese MA; Center for Molecular Neurobiology, University Medical Center, Hamburg-Eppendorf, 20251 Hamburg, Germany.
Beckhove P; Department of Translational Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
von Deimling A; 1] Department of Neuropathology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Wick W; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Platten M; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
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Źródło:
Nature [Nature] 2014 Aug 21; Vol. 512 (7514), pp. 324-7. Date of Electronic Publication: 2014 Jun 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cancer Vaccines/*immunology
Cancer Vaccines/*therapeutic use
Glioma/*immunology
Glioma/*therapy
Isocitrate Dehydrogenase/*genetics
Isocitrate Dehydrogenase/*immunology
Mutant Proteins/*immunology
Animals ; Antibody Specificity ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Female ; Glioma/enzymology ; Glioma/genetics ; Histocompatibility Antigens Class II/immunology ; Humans ; Immunity, Humoral ; Immunotherapy/methods ; Male ; Mice ; Mutant Proteins/genetics ; Mutation ; T-Lymphocytes, Helper-Inducer/immunology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1.
Autorzy:
Klink B; Institut für Klinische Genetik, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Miletic H
Stieber D
Huszthy PC
Campos Valenzuela JA
Balss J
Wang J
Schubert M
Sakariassen PØ
Sundstrøm T
Torsvik A
Aarhus M
Mahesparan R
von Deimling A
Kaderali L
Niclou SP
Schröck E
Bjerkvig R
Nigro JM
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Źródło:
PloS one [PLoS One] 2013; Vol. 8 (3), pp. e59773. Date of Electronic Publication: 2013 Mar 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Disease Models, Animal*
DNA Helicases/*genetics
DNA-Binding Proteins/*genetics
Isocitrate Dehydrogenase/*genetics
Oligodendroglioma/*genetics
Repressor Proteins/*genetics
Animals ; Base Sequence ; DNA Fingerprinting ; DNA Primers/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; Immunohistochemistry ; Magnetic Resonance Imaging ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Microarray Analysis ; Molecular Sequence Data ; RNA-Binding Proteins ; Sequence Analysis, DNA ; Transplantation, Heterologous
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1- mutation as common tumor initiating event.
Autorzy:
Lass U; Clinical Cooperation Unit Neuropathology, German Cancer Center (DKFZ), Heidelberg, Germany.
Nümann A
von Eckardstein K
Kiwit J
Stockhammer F
Horaczek JA
Veelken J
Herold-Mende C
Jeuken J
von Deimling A
Mueller W
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (7), pp. e41298. Date of Electronic Publication: 2012 Jul 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation*
Astrocytoma/*genetics
Astrocytoma/*pathology
Isocitrate Dehydrogenase/*genetics
Oligodendroglioma/*genetics
Oligodendroglioma/*pathology
Adolescent ; Adult ; Child ; Clone Cells/metabolism ; Clone Cells/pathology ; Codon/genetics ; Disease Progression ; Female ; Humans ; Loss of Heterozygosity/genetics ; Male ; Middle Aged ; Recurrence ; Tumor Suppressor Protein p53/genetics ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Immunohistochemical analysis of 1844 human epithelial and haematopoietic tumours and sarcomas for IDH1R132H mutation.
Autorzy:
Sahm F; Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
Capper D
Meyer J
Hartmann C
Herpel E
Andrulis M
Mechtersheimer G
Petersen I
Paulus W
von Deimling A
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Źródło:
Histopathology [Histopathology] 2011 Jun; Vol. 58 (7), pp. 1167-72.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation*
Carcinoma/*genetics
Isocitrate Dehydrogenase/*genetics
Lymphoma/*genetics
Neoplasms/*genetics
Sarcoma/*genetics
Carcinoma/metabolism ; Carcinoma/pathology ; Female ; Humans ; Immunohistochemistry ; Isocitrate Dehydrogenase/metabolism ; Lymphoma/metabolism ; Lymphoma/pathology ; Male ; Neoplasms/metabolism ; Neoplasms/pathology ; Sarcoma/metabolism ; Sarcoma/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Increased levels of 2-hydroxyglutarate in AML patients with IDH1-R132H and IDH2-R140Q mutations.
Autorzy:
Sellner L
Capper D
Meyer J
Langhans CD
Hartog CM
Pfeifer H
Serve H
Ho AD
Okun JG
Krämer A
Von Deimling A
Pokaż więcej
Źródło:
European journal of haematology [Eur J Haematol] 2010 Nov; Vol. 85 (5), pp. 457-9.
Typ publikacji:
Letter
MeSH Terms:
Mutation, Missense*
Glutarates/*analysis
Isocitrate Dehydrogenase/*genetics
Leukemia, Myeloid, Acute/*genetics
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Biomarker and Histopathology Evaluation of Patients with Recurrent Glioblastoma Treated with Galunisertib, Lomustine, or the Combination of Galunisertib and Lomustine.
Autorzy:
Capper, David
von Deimling, Andreas andreas.
Brandes, Alba A.
Carpentier, Antoine F.
Kesari, Santosh
Sepulveda-Sanchez, Juan M.
Wheeler, Helen R.
Chinot, Olivier
Cher, Lawrence
Steinbach, Joachim P.
Specenier, Pol
Rodon, Jordi
Cleverly, Ann
Smith, Claire
Gueorguieva, Ivelina
Miles, Colin
Guba, Susan C.
Desaiah, Durisala
Estrem, Shawn T.
Lahn, Michael M.
Pokaż więcej
Źródło:
International Journal of Molecular Sciences. May2017, Vol. 18 Issue 5, p995. 15p. 3 Charts, 2 Graphs.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas.
Autorzy:
Brand, Frank
Förster, Alisa
Christians, Anne
Bucher, Martin
Thomé, Carina M.
Raab, Marc S.
Westphal, Manfred
Pietsch, Torsten
von Deimling, Andreas
Reifenberger, Guido
Claus, Peter
Hentschel, Bettina
Weller, Michael
Weber, Ruthild G.
Pokaż więcej
Temat:
ASTROCYTOMAS
CELL migration
ISOCITRATE dehydrogenase
CELL cycle
ASTROCYTES
PATHOLOGY
MICROTUBULES
Źródło:
Acta Neuropathologica; Jan2020, Vol. 139 Issue 1, p175-192, 18p
Czasopismo naukowe
Szczegóły
Tytuł:
Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma.
Autorzy:
Makarevic, Anastasia
Rapp, Carmen
Dettling, Steffen
Reuss, David
Jungk, Christine
Abdollahi, Amir
von Deimling, Andreas
Unterberg, Andreas
Herold-Mende, Christel
Warta, Rolf
Pokaż więcej
Temat:
GLIOMAS
ISOCITRATE dehydrogenase
T cells
Źródło:
International Journal of Molecular Sciences; Oct2020, Vol. 21 Issue 20, p7801-7801, 1p
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 36

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